Hub : Genes

CCNJ

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.186	0.0640	9.5e-04	-0.004	NA	0.025	NA	0.003	5.8e-01	NA	0.01800	NA	2.2e-01
2	GTEx	Breast Mammary Tissue (Female)	0.268	0.0955	6.3e-03	0.102	NA	0.064	NA	0.104	6.0e-04	NA	0.00570	NA	5.4e-04
3	GTEx	Prostate	0.231	0.1060	8.5e-03	0.178	NA	0.003	NA	0.027	3.1e-05	NA	0.27000	NA	7.1e-02
4	TCGA	Thyroid Carcinoma	0.071	0.0320	3.1e-05	0.053	0.059	0.032	NA	0.045	6.6e-06	2e-06	0.00044	NA	3.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.8	2.9	7.6	-1.7	-0.8	0.6	-2.8
Bipolar Disorder or Schizophrenia	0.2	0.4	1.5	1.2	0.3	0.1	-0.2
Depressed Affect (Nagel 2018)	2.2	4.6	8.5	-1.9	-2.9	-1.5	-2.0
Depression (Nagel 2018)	0.3	0.5	1.0	-0.3	-0.8	-1.0	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	-0.3	-0.6	-0.6	1.3
Neuroticism (Nagel 2018)	1.6	3.7	6.5	-2.3	-2.5	-1.1	-1.2
Schizophrenia (2018)	1.5	3.2	9.0	3.0	1.0	-0.4	1.6
Schizophrenia vs Biploar Disorder	3.5	4.6	8.8	2.7	0.6	-1.4	3.0
Worry (Nagel 2018)	1.6	3.4	7.7	-2.8	-2.3	-0.5	-0.6
Alzheimer’s Disease (in mother)	3.2	3.7	13.2	-0.7	0.5	-1.0	-3.6
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-0.2	0.6	1.0	-0.8
Alzheimer’s Disease (including proxy)	3.0	4.4	15.7	0.1	1.4	-0.3	-4.0
Crohns Disease (2017)	2.1	4.6	15.1	1.7	0.2	-3.9	0.7
Irritable Bowel Disease (IBD)	1.0	2.3	5.4	1.7	0.6	-2.3	0.8
Ulcerative Colitis (UC)	0.2	0.3	1.0	1.0	0.4	0.1	0.1
Major Depression (MDD)	0.5	0.6	1.5	-0.3	-1.2	-0.5	0.9
Reaction Time	0.5	0.9	3.3	1.8	0.2	-0.4	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	-0.3	-0.4	-1.3	0.8
Breast Cancer	0.2	0.5	1.1	1.1	0.6	0.6	0.3
Ovarian Cancer	0.8	1.0	2.4	-0.6	-1.2	0.2	1.6
Prostate Cancer	0.7	1.0	3.2	-0.0	-0.2	0.8	-1.8
Age at First Birth	1.4	2.0	6.4	-0.5	1.0	2.5	-0.7
Bipolar Disorder (2011)	3.2	3.1	8.0	-1.6	-0.6	1.2	-2.8
Body Mass Index (BMI) (2010)	0.1	0.2	0.2	0.4	-0.3	-0.4	-0.5
Coronary Artery Disease (CAD)	0.8	1.0	2.1	-1.4	-1.3	-0.1	0.5
Crohns Disease (2012)	1.1	1.8	6.8	0.4	-0.6	-2.6	0.1
Mean Putamen Volume	1.6	1.8	3.3	-1.8	-1.5	-1.1	-0.5
Fasting Glucose	1.2	1.5	4.1	0.9	1.0	-0.0	2.0
HbA1C	1.0	1.1	2.7	0.2	1.2	-1.6	0.4
HDL Cholesterol	0.9	1.6	2.7	1.6	0.0	1.4	1.3
LDL Cholesterol	1.3	2.1	5.0	0.1	1.0	-2.2	-1.5
Lupus	1.5	2.3	7.0	1.0	1.0	2.6	-0.4
Neuroticism (2016)	1.7	2.4	7.1	0.8	0.9	-2.7	-1.0
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.0	-0.7	0.7	-0.6
Rheumatoid Arthritis	1.0	1.3	2.6	-0.6	-1.3	0.8	1.6
Schizophrenia (2014)	1.2	2.6	7.6	2.8	0.9	-0.2	1.4
Triglycerides	0.2	0.3	0.6	-0.4	0.4	-0.8	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.9	-0.3	0.2	0.7
Ulcerative Colitis	0.6	0.8	2.3	0.4	0.7	1.5	0.6
Blood Eosinophil Count	0.2	1.8	3.5	0.2	-1.9	-1.7	0.9
Blood Platelet Count	1.5	17.0	53.1	-1.9	-3.3	7.3	0.1
Blood Red Count	0.1	1.4	3.7	1.1	0.7	-1.9	0.5
Blood White Count	0.2	1.2	3.7	0.1	-0.7	1.9	-0.7
Heel T-Score	0.5	4.1	7.8	1.4	2.3	-1.1	-2.8
BMI	0.5	2.8	4.2	2.0	-1.4	-2.0	0.8
Height	0.3	5.2	12.4	-3.5	0.6	2.2	1.8
Waist Hip Ratio (WHR)	0.5	2.2	4.0	0.6	1.8	2.0	-1.1
Systolic Blood Pressure	0.1	0.3	0.5	0.5	0.4	0.7	-0.4
Smoking Status	0.5	1.1	2.9	1.3	0.0	-1.7	-0.0
Allergy or Eczema	0.0	0.1	0.2	-0.2	0.5	0.1	-0.2
Cardiovascular Disease	0.3	0.9	1.7	-1.3	-1.1	-0.4	-0.8
Hypothyroidism (self reported)	0.1	0.3	0.7	0.2	-0.8	0.5	0.3
Respiratory disease	0.3	0.6	1.7	-1.3	-0.7	-0.5	-0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	0.4	-0.5	-0.7	-0.5
Lung FEV1/FVC ratio	0.4	2.2	3.7	-1.9	-1.1	1.3	-1.5
Lung FVC	0.2	1.0	2.5	0.7	0.1	1.1	1.6
Neuroticism	1.3	3.1	4.7	-2.0	-2.2	-1.6	-1.0
Chronotype (morning person)	0.7	1.6	4.1	-1.4	-2.0	-0.1	0.5
Hair Pigment	0.0	1.0	3.2	0.4	0.3	1.8	-0.7
Tanning	0.1	1.7	6.1	-0.3	-0.6	2.5	-0.2
Hand grip strength (left)	0.4	1.0	2.2	-1.1	-0.4	1.5	0.6
Number of treatments/medications taken	0.5	0.9	1.8	0.2	-1.3	-0.5	1.4
Average weekly spirits intake	0.6	0.8	2.2	-0.1	-0.2	-0.9	1.5
Sensitivity / hurt feelings	0.3	0.6	1.0	-0.2	0.7	-1.0	-0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.8	-0.5	-0.4	-0.9	-1.4
Hearing difficulty/problems: Yes	2.3	3.5	7.6	-2.8	-2.0	-1.7	0.2
Relative age of first facial hair	1.9	4.0	8.7	-1.8	-2.9	-1.8	0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.2	-0.8	0.2	0.2
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.9	1.2	0.3	-0.9	2.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	0.6	0.3	-1.3	-1.0
Systolic blood pressure, automated reading	0.2	0.6	0.8	0.4	-0.8	-0.9	0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.0	0.8	0.4	-0.4	-1.4
Angina	0.4	0.5	2.1	0.1	-0.0	-0.1	-1.5
Medication for hormone replacement therapy	0.6	0.7	1.6	0.8	0.4	-0.4	1.3
Vitamin and mineral supplements	0.3	0.4	1.2	0.2	-0.0	-0.5	1.1
Supplements: Zinc	0.4	0.4	1.0	-0.5	0.7	1.0	0.1
Medication: Co-codamol	1.4	1.6	3.2	-0.8	-1.8	-0.4	1.6
Medication: Metformin	0.3	0.4	1.0	0.6	-0.5	-0.3	-1.0
Diabetes (father)	1.9	2.4	4.6	-2.1	-0.8	1.3	-1.6
Diabetes (mother)	0.7	0.8	2.0	-1.0	-1.4	0.2	-0.6
Severe depression (siblings)	0.7	0.8	2.0	1.4	0.2	1.0	0.4
Pack years adult smoking proportion	0.5	0.7	1.7	1.0	0.2	-0.4	1.3
Impedance of leg (right)	0.4	2.1	6.7	-2.6	-0.5	1.1	0.1
Leg fat-free mass (left)	0.1	0.5	1.3	0.4	0.7	-0.5	-1.1
Trunk fat percentage	0.2	0.7	2.1	0.6	-0.6	-1.5	0.2
Hand grip strength (right)	0.8	2.1	5.2	-2.3	-0.3	1.8	-0.0
Townsend deprivation index at recruitment	2.4	3.4	10.5	-1.0	-0.6	-1.4	-3.2
Current tobacco smoking	0.8	1.4	2.4	1.2	-1.6	-0.9	0.8
Average weekly fortified wine intake	0.3	0.4	1.1	0.5	-0.2	-0.4	1.1
Maternal smoking around birth	0.4	0.6	1.6	1.3	-0.5	-0.2	-0.6
Fed-up feelings	4.0	7.3	9.5	-2.8	-2.9	-1.8	-3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.1	-0.2	-0.6	-0.6
Relative age voice broke	0.8	1.2	2.3	-0.5	-1.4	-1.5	0.4
Taking other prescription medications	0.0	0.1	0.2	0.4	-0.3	-0.1	-0.0
Age when periods started (menarche)	2.1	5.1	17.8	-0.7	1.4	0.0	4.2
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	5.7	0.2	0.8	2.4	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	1.9	1.2	1.3	-1.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	-0.0	-0.9	-1.1	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-0.1	-0.5	0.1	-1.0
Serious illness, injury or assault to yourself	0.5	0.6	1.6	1.3	0.2	-0.6	-0.5
High blood pressure	0.2	0.7	2.2	0.1	-1.5	-0.6	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.0	0.6	0.5	-0.3
Multivitamins +/- minerals	0.2	0.3	0.4	-0.7	-0.3	-0.4	-0.7
Stomach or abdominal pain in last month	1.5	1.9	4.1	-2.0	-1.4	-0.2	-1.3
Supplements: Glucosamine	0.2	0.2	0.5	-0.3	0.7	0.5	0.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.6	-1.5	-1.0	1.6	0.6
Medication: Atenolol	0.6	0.8	2.8	0.3	-0.3	0.5	-1.7
Medication: Levothyroxine sodium	0.4	0.7	1.6	0.9	-0.1	1.3	0.6
Sitting height	0.7	5.2	10.6	-3.3	1.0	3.0	-0.7
Chronic bronchitis/emphysema (father)	1.2	1.4	2.6	0.1	-0.9	-1.4	1.6
High blood pressure (mother)	1.5	2.2	4.0	-1.9	-2.0	0.0	-1.0
Body mass index (BMI)	0.4	1.8	3.1	1.8	-1.0	-1.7	0.4
Impedance of leg (left)	0.5	2.5	7.6	-2.8	-1.0	1.0	0.6
Leg predicted mass (left)	0.1	0.6	1.4	0.4	0.8	-0.5	-1.2
Trunk fat mass	0.1	0.4	1.5	0.4	-0.3	-1.2	0.0
Waist circumference	0.3	1.0	2.2	1.5	0.3	-1.3	-0.2
Number of incorrect matches in round	2.2	3.7	5.7	2.1	2.4	-1.6	-1.4
Past tobacco smoking	0.7	1.3	4.7	-0.5	-0.2	2.2	0.2
Alcohol usually taken with meals	0.3	0.5	1.6	-0.3	0.3	1.3	0.6
Nervous feelings	0.7	1.2	2.4	-1.1	-1.6	-0.4	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.6	-1.4	-1.8	-1.2	-1.9
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-0.8	-0.5	-1.1	0.1
Hair/balding pattern: Pattern 2	1.4	1.8	3.6	1.9	1.4	-1.1	-0.5
Had menopause	2.4	3.1	8.6	1.2	-0.8	-1.2	2.9
Had other major operations	1.1	1.3	2.8	-1.2	-1.0	1.7	-0.2
Forced vital capacity (FVC)	0.5	1.9	4.0	-2.0	0.1	1.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.1	0.8	1.6	-1.8	-0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.6	0.2	-0.3	-1.6	-1.3
Qualifications: None of the above	0.5	1.0	1.7	-0.7	-1.3	-0.7	1.2
Financial difficulties in last 2 years	0.6	0.8	2.9	-0.2	0.2	0.6	-1.7
Mouth/teeth dental problems	0.4	0.6	1.6	0.5	0.8	0.3	-1.2
Heart attack	0.3	0.4	0.9	0.2	1.0	0.7	-0.2
Allergy	0.3	0.7	2.2	1.5	0.7	-0.3	0.6
Pain all over the body in last month	0.9	1.0	1.4	-0.6	-1.2	0.9	1.2
Diabetes (self-reported)	0.5	0.8	2.4	0.7	-0.0	-1.6	-0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	1.1	1.0	0.7	-0.4
Medication: Ramipril	0.5	0.7	1.9	0.8	-0.4	-0.1	1.4
Medication: Simvastatin	0.3	0.4	1.0	0.7	1.0	-0.1	0.2
Fluid intelligence score	0.3	0.7	1.3	-1.0	-0.3	-1.1	-0.6
Illnesses of siblings	0.3	0.4	1.3	-0.4	-0.1	0.3	1.2
Neuroticism score	1.5	3.2	4.6	-2.1	-1.6	-1.7	-1.6
Weight	0.0	0.2	0.7	0.4	-0.2	-0.9	-0.2
Impedance of arm (right)	0.2	0.9	3.1	-1.8	-0.1	0.7	-0.1
Arm fat percentage (right)	0.3	1.0	1.3	1.1	-1.0	-1.1	0.8
Trunk fat-free mass	0.1	0.4	0.8	-0.3	0.8	-0.1	-0.9
Hip circumference	0.3	1.4	4.1	1.0	-0.8	-2.0	0.2
Time employed in main current job	0.8	0.9	1.8	-0.8	-1.1	-0.3	1.3
Alcohol intake versus 10 years previously	0.4	0.6	1.2	0.4	1.1	0.4	-0.9
Father’s age at death	0.4	0.5	0.6	-0.8	0.6	0.8	0.5
Worrier / anxious feelings	0.3	0.5	1.4	-0.4	0.2	-0.6	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.8	-1.0	-2.2	-1.1	-0.5
Falls in the last year	1.0	1.3	3.2	-1.1	-1.8	0.9	-0.4
Hair/balding pattern: Pattern 3	0.3	0.5	0.7	-0.4	-0.7	-0.8	0.7
Number of live births	0.7	1.0	2.5	1.2	0.0	0.1	1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	5.6	-2.0	0.5	2.4	-0.9
Pulse rate	1.1	1.9	3.7	-1.9	-1.8	0.4	-0.9
Happiness	3.1	3.8	9.7	-2.1	-1.0	-0.2	-3.1
Noisy workplace	0.2	0.2	0.4	-0.6	-0.4	-0.6	-0.2
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.7	1.4	2.2	1.6	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.5	-1.2	-0.8	-0.7	-1.2
Mouth/teeth dental problems: Dentures	0.9	1.5	4.0	-0.1	-0.3	-1.4	2.0
Asthma	0.8	1.5	4.2	-2.0	-0.9	-0.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.6	-1.6	-0.7	0.6	-0.7
Medication: Cholesterol lowering	0.5	0.7	1.9	0.8	1.4	-0.3	-0.6
Depression (self-reported)	0.1	0.1	0.4	-0.1	-0.6	0.3	-0.0
Medication: Lansoprazole	3.3	3.8	6.3	1.7	0.2	2.5	2.5
Prospective memory result	0.1	0.1	0.2	-0.4	0.1	-0.2	-0.4
Lung cancer (father)	1.6	1.9	5.7	0.2	-0.1	-2.4	-1.4
Illnesses of mother	1.5	1.9	3.7	1.3	1.9	1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	5.5	-2.3	-0.0	2.0	-1.1
Pulse wave Arterial Stiffness index	1.3	1.6	3.4	1.9	0.5	1.6	-0.1
Impedance of arm (left)	0.2	1.0	2.3	-1.5	0.5	1.0	-0.8
Arm fat mass (right)	0.1	0.5	1.0	0.9	-0.6	-1.0	0.2
Trunk predicted mass	0.1	0.4	0.7	-0.2	0.8	-0.1	-0.9
Standing height	0.4	4.0	7.7	-2.8	1.8	1.6	-1.5
Length of working week for main job	2.6	2.9	4.6	-1.5	-2.1	0.0	2.1
Exposure to tobacco smoke at home	1.7	1.9	4.0	-0.8	0.5	-2.0	-1.6
Breastfed as a baby	1.3	1.6	3.3	1.8	0.3	0.6	1.7
Tense / ‘highly strung’	1.9	3.2	6.9	-2.6	-1.7	-1.4	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.6	0.2	-0.5	-0.0
Hair/balding pattern: Pattern 4	0.5	1.1	1.9	1.4	1.2	0.0	1.1
Birth weight of first child	0.4	0.7	1.3	0.3	-1.1	1.1	-0.5
Peak expiratory flow (PEF)	0.8	1.9	2.6	-1.3	0.9	1.5	-1.6
Pulse wave reflection index	1.2	1.4	2.3	1.5	1.5	0.6	-1.0
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	-0.8	-0.3	-1.7	-0.6
Loud music exposure frequency	1.9	2.1	5.3	-1.7	-2.3	0.3	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.1	0.5	1.0	1.0	-0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	2.0	1.4	-0.0	-0.5	-0.2
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.1	0.8	0.1	-0.8
Medication: Paracetamol	1.3	2.1	4.8	-1.4	-2.2	-1.1	0.8
Headache pain in last month	0.2	0.4	0.9	-0.4	0.1	-0.7	-0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	6.6	-1.7	-2.6	-0.3	0.0
Glaucoma (self-reported)	0.1	0.1	0.1	-0.2	-0.1	-0.3	-0.3
Gout (self-reported)	0.6	0.8	1.2	-0.8	0.9	-0.6	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	0.7	-0.3	0.7	0.6
Medication: Amlodipine	1.3	1.9	3.4	1.8	1.8	-0.8	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	-1.0	0.4	0.4	-0.2
Birth weight	0.4	0.8	2.4	-1.6	-0.0	-0.5	-0.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	-0.4	-0.4	-0.7	0.4
High blood pressure (siblings)	0.3	0.4	1.4	-0.1	-0.5	0.3	-1.2
Forced vital capacity (FVC), Best measure	0.7	2.7	7.5	-2.7	-0.3	1.7	-0.5
Body fat percentage	0.2	0.8	1.9	0.7	-0.8	-1.4	0.5
Leg fat percentage (right)	0.3	1.0	2.0	0.6	-1.2	-1.4	0.5
Arm fat-free mass (right)	0.1	0.3	0.7	-0.2	0.7	-0.1	-0.8
Exposure to tobacco smoke outside home	0.8	1.0	1.8	-1.1	-1.0	-1.3	0.1
Comparative body size at age 10	0.7	1.8	4.4	1.3	1.0	-2.1	0.3
Number of full brothers	0.5	0.6	2.1	0.2	-0.4	-1.5	0.2
Worry too long after embarrassment	0.2	0.3	1.1	1.0	-0.2	0.2	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.1	0.9	0.3	-1.1	0.5
Wheeze or whistling in the chest in last year	1.3	2.4	4.9	-2.2	-1.6	-1.1	-0.9
Number of children fathered	0.8	0.9	3.0	-0.6	-0.2	-0.0	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.6	0.7	-0.7	-1.3	0.8
Age at first live birth	0.9	1.7	2.8	1.2	1.6	1.7	0.1
Pulse wave peak to peak time	1.5	1.8	4.5	-2.1	-0.5	-1.5	-0.0
Health satisfaction	2.6	3.3	8.0	-1.9	-2.8	-0.7	-1.1
Shortness of breath walking on level ground	0.6	0.7	1.4	-1.2	-1.1	-0.0	-0.5
Qualifications: College or University degree	1.2	3.9	5.9	2.2	2.4	2.1	0.8
Eye problems/disorders: None of the above	0.3	0.4	0.8	-0.8	0.9	0.0	-0.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.9	1.4	2.2	-0.2	-0.7
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.3	-1.0	-0.7	0.5
Medication for pain relief, constipation, heartburn	1.5	2.5	5.3	2.1	2.3	0.7	0.2
Neck or shoulder pain in last month	1.1	1.5	3.7	-0.8	0.5	-1.2	-1.9
Medication: Blood pressure	1.6	2.8	5.6	2.4	2.3	0.0	0.7
Angina (self-reported)	0.5	0.7	2.7	0.1	-0.0	0.2	-1.6
Migraine (self-reported)	0.9	1.2	3.3	1.0	-0.4	0.4	1.8
Medication: Ibuprofen	1.4	1.7	3.8	-2.0	-1.4	0.8	-0.7
Medication: Allopurinol	1.4	1.8	4.5	1.7	2.1	-0.3	-0.1
Medication: Omeprazole	0.7	0.8	1.9	-0.9	-1.4	-0.7	-0.0
Medication: Seretide 50 evohaler	0.7	0.8	1.7	1.3	0.9	0.9	-0.1
Mean time to correctly identify matches	1.8	3.3	8.1	2.8	1.0	-1.7	1.2
Heart disease (mother)	1.5	1.9	3.9	-0.5	-1.7	-2.0	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.6	0.4	0.3	-2.1	-0.6
Whole body fat mass	0.1	0.5	1.5	0.5	-0.6	-1.2	0.2
Leg fat mass (right)	0.1	0.6	1.3	0.6	-0.7	-1.1	0.3
Arm predicted mass (right)	0.0	0.2	0.5	-0.3	0.3	-0.2	-0.7
Pulse rate, automated reading	0.9	3.0	7.5	-1.9	-2.7	-0.7	-0.8
Alcohol intake frequency.	0.8	1.8	5.6	0.4	-1.2	-2.4	0.2
Comparative height size at age 10	0.5	2.9	5.5	-2.1	1.2	-0.2	-2.3
Number of full sisters	1.3	1.5	3.8	-0.2	0.6	-1.4	-2.0
Suffer from ‘nerves’	2.8	4.3	9.2	-2.7	-3.0	-0.5	-0.8
Overall health rating	1.8	4.0	6.8	-2.5	-2.6	-0.2	-1.6
Chest pain or discomfort	0.1	0.1	0.3	0.1	-0.0	0.2	0.5
Had major operations	0.2	0.3	0.4	-0.3	-0.5	-0.6	-0.6
Age at last live birth	1.9	2.8	5.6	2.4	2.1	0.6	0.9
Family relationship satisfaction	0.4	0.5	1.0	1.0	0.2	0.3	-0.9
Leg pain on walking	0.5	0.7	1.5	-0.1	-0.1	-1.2	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	0.3	-0.8	-1.4	-0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.1	0.1	-0.8	0.4	2.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	1.7	0.3	-0.2	1.0
Medication: Aspirin	0.3	0.4	1.2	0.1	-0.4	0.4	1.1
Supplements: Vitamin C	1.5	1.8	3.9	1.0	1.5	2.0	0.0
Knee pain experienced in last month	0.3	0.4	0.9	0.1	0.7	-0.9	-0.6
Hypertension (Self-reported)	0.1	0.3	0.9	0.4	-0.9	-0.4	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	-0.2	-0.6	1.0	1.4
Illnesses of father: Heart disease	0.1	0.2	0.4	0.1	0.5	0.7	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.6	0.8	-0.1	-0.2	-0.4
Smoking status: Previous	0.6	0.9	2.0	0.4	1.1	-1.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	7.3	-1.2	1.3	2.7	-0.9
Whole body fat-free mass	0.1	0.4	0.8	-0.0	0.7	-0.3	-0.9
Leg fat-free mass (right)	0.1	0.3	0.7	0.3	0.5	-0.5	-0.8
Arm fat percentage (left)	0.2	0.8	1.5	1.2	-0.8	-1.0	0.5
Average weekly red wine intake	0.4	0.6	1.7	1.3	0.1	0.8	0.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.1	-1.8	-0.9	1.0	-0.7
Mood swings	1.1	1.9	3.1	-1.3	-1.6	-0.6	-1.8
Loneliness, isolation	1.0	1.4	3.3	-1.0	-0.1	-1.2	-1.8
Long-standing illness, disability or infirmity	0.5	0.8	1.7	0.2	-0.2	-1.3	-1.2
Ever had bowel cancer screening	0.0	0.0	0.1	-0.1	0.1	0.3	0.1
Diabetes diagnosed by doctor	0.8	1.2	4.2	0.6	-0.4	-2.0	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	3.0	-1.6	-1.7	-0.8	-1.6
Friendships satisfaction	0.7	0.9	1.3	0.2	1.0	1.2	-1.1
Qualifications: nursing, teaching	0.7	1.1	2.9	0.3	1.1	0.5	-1.7
Commuting to job workplace: Walk	1.5	1.6	3.3	-0.4	0.3	-1.8	-1.7
Eye problems/disorders: Cataract	1.2	1.4	3.2	-0.8	-1.8	0.9	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.4	-0.4	-0.4	1.0	1.2
Medication for cholesterol	0.8	1.1	1.7	0.7	1.3	1.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	0.3	0.9	0.5	0.3
Back pain experienced in last month	1.4	2.0	5.4	-1.0	0.2	-1.3	-2.3
Mineral and other dietary supplements	0.5	0.7	2.5	-0.4	-0.1	0.1	-1.6
Breast cancer (self-reported)	1.1	1.3	3.2	-1.1	-0.6	0.4	-1.8
Asthma (self-reported)	1.2	2.3	6.2	-2.5	-1.2	-0.1	-1.2
Osteoporosis (self-reported)	1.1	1.4	3.6	1.3	-0.3	0.4	1.9
Osteoarthritis (self-reported)	0.7	1.0	3.3	0.7	-0.1	-1.8	-0.2
Medication: Aspirin	0.2	0.2	0.5	0.2	-0.1	0.5	0.7
Medication: Gliclazide	2.1	2.3	5.9	-0.5	-1.7	-2.4	0.3
Illnesses of father: None of the above (group 1)	1.3	1.6	4.7	2.2	1.0	-0.6	0.6
Smoking status: Current	0.8	1.3	2.2	1.2	-1.5	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.6	-0.9	-0.4	1.9	-0.3
Whole body water mass	0.1	0.3	0.8	-0.1	0.7	-0.1	-0.9
Leg predicted mass (right)	0.1	0.3	0.7	0.3	0.5	-0.5	-0.8
Arm fat mass (left)	0.1	0.5	0.8	0.9	-0.5	-0.9	-0.0
Number of self-reported non-cancer illnesses	1.1	1.8	4.8	-0.5	-2.2	-1.4	-0.4
Average weekly champagne plus white wine intake	0.7	0.9	3.4	0.3	-0.1	0.4	-1.8
Miserableness	1.2	2.1	3.0	-0.9	-1.7	-1.7	-1.3
Guilty feelings	0.4	0.5	1.2	-0.1	0.1	-1.1	-0.9
Wears glasses or contact lenses	0.5	0.5	1.1	-0.4	-0.6	-1.0	-0.7
Ever taken oral contraceptive pill	2.4	2.7	7.4	2.7	1.8	0.4	-0.2
Hearing aid user	1.9	2.2	2.9	-1.7	-1.6	1.0	1.5
Mother’s age at death	0.6	0.8	2.3	-0.1	1.5	0.6	-0.5
Financial situation satisfaction	2.0	2.4	5.3	1.2	2.3	0.9	-1.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	-0.9	-0.3	-0.8	-0.8
Commuting to job workplace: Public transport	1.6	1.9	3.8	-0.1	1.2	1.5	-2.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.7	0.1	-0.8	0.4
Medication: Blood pressure	0.6	1.1	3.7	-0.6	-1.9	0.0	-0.5
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.0	1.1	-0.7	-1.2	1.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.0	-0.0	-1.0	-0.8	2.0
High cholesterol (Self-reported)	0.3	0.6	1.9	-1.4	0.3	-0.4	-0.4
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	-0.4	-0.1	-0.6
Medication: Paracetamol	1.8	2.7	6.1	-1.9	-2.5	-1.0	0.5
Medication: Lisinopril	1.0	1.4	4.3	0.9	-0.5	-0.3	2.1
Medication: Atorvastatin	1.3	1.6	4.8	0.7	1.1	-2.2	-0.2
Illnesses of father: High blood pressure	1.2	1.5	3.0	-1.6	-0.1	0.6	-1.7
Alcohol drinker status: Never	0.6	0.7	1.6	1.3	-0.8	-0.5	0.5
Ever smoked	0.7	1.3	4.7	-0.2	-0.3	-2.2	-0.6
Basal metabolic rate	0.0	0.3	0.7	-0.0	0.5	-0.4	-0.8
Leg fat percentage (left)	0.4	1.5	2.9	0.4	-1.5	-1.7	0.7
Arm fat-free mass (left)	0.0	0.2	0.4	-0.5	0.1	-0.3	-0.7
Number of operations (self-reported)	0.8	1.2	2.9	-1.0	-0.6	0.9	-1.7
Average weekly beer plus cider intake	0.5	0.7	1.3	-0.6	-1.0	-1.1	-0.1
Irritability	1.3	2.3	4.2	-1.5	-1.4	-2.0	-0.9
Risk taking	1.7	2.4	5.0	0.8	1.5	-1.4	-2.2
Ever had prostate specific antigen (PSA) test	2.3	2.7	4.2	-2.0	-0.9	1.2	-2.0
Fractured/broken bones in last 5 years	0.3	0.3	0.9	1.0	0.4	0.0	-0.4
Age started oral contraceptive pill	1.2	1.5	4.0	0.8	0.7	-2.0	-0.9
Diastolic blood pressure, automated reading	0.3	1.0	3.1	-0.9	-1.8	-0.5	-0.1
Ever depressed for a whole week	0.9	1.1	2.5	-0.3	-1.3	-1.6	-0.3
Unable to work because of sickness or disability	0.1	0.1	0.3	0.1	-0.3	0.5	0.3
Commuting to job workplace: Cycle	0.3	0.3	0.5	-0.6	0.7	0.5	-0.3
Myopia	0.7	1.1	1.6	-0.9	1.0	1.2	-0.9
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.2	0.8	0.4	0.4
Cholesterol lowering medication	1.2	1.8	6.2	-0.9	-0.4	-2.5	0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	-0.7	-1.0	-1.7	-0.1
Pain experienced in last month	1.1	1.8	2.7	1.3	-0.7	1.6	1.5
Supplements: Calcium	1.7	1.9	3.4	1.8	1.4	-0.4	1.5
Basal cell carcinoma (self-reported)	1.0	1.2	2.6	-1.6	-1.0	0.9	0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.0	0.8	0.7	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.1	0.9	0.3	-0.9
Heart disease (siblings)	1.1	1.3	3.1	-0.5	0.7	-1.2	-1.8
Alcohol drinker status: Previous	1.6	1.8	3.8	1.9	0.6	-1.7	-0.2
Pack years of smoking	0.7	1.1	1.9	1.4	0.8	-0.3	1.3
Impedance of whole body	0.3	1.6	5.1	-2.3	0.0	1.0	-0.5
Leg fat mass (left)	0.2	0.7	1.6	0.4	-1.0	-1.3	0.4
Arm predicted mass (left)	0.0	0.1	0.2	-0.1	0.4	-0.3	-0.4