Hub : Genes

CCNJ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.186 0.0640 9.5e-04 -0.004 NA 0.025 NA 0.003 5.8e-01 NA 0.01800 NA 2.2e-01
2 GTEx Breast Mammary Tissue (Female) 0.268 0.0955 6.3e-03 0.102 NA 0.064 NA 0.104 6.0e-04 NA 0.00570 NA 5.4e-04
3 GTEx Prostate 0.231 0.1060 8.5e-03 0.178 NA 0.003 NA 0.027 3.1e-05 NA 0.27000 NA 7.1e-02
4 TCGA Thyroid Carcinoma 0.071 0.0320 3.1e-05 0.053 0.059 0.032 NA 0.045 6.6e-06 2e-06 0.00044 NA 3.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.8 2.9 7.6 -1.7 -0.8 0.6 -2.8
Bipolar Disorder or Schizophrenia 0.2 0.4 1.5 1.2 0.3 0.1 -0.2
Depressed Affect (Nagel 2018) 2.2 4.6 8.5 -1.9 -2.9 -1.5 -2.0
Depression (Nagel 2018) 0.3 0.5 1.0 -0.3 -0.8 -1.0 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.7 -0.3 -0.6 -0.6 1.3
Neuroticism (Nagel 2018) 1.6 3.7 6.5 -2.3 -2.5 -1.1 -1.2
Schizophrenia (2018) 1.5 3.2 9.0 3.0 1.0 -0.4 1.6
Schizophrenia vs Biploar Disorder 3.5 4.6 8.8 2.7 0.6 -1.4 3.0
Worry (Nagel 2018) 1.6 3.4 7.7 -2.8 -2.3 -0.5 -0.6
Alzheimer’s Disease (in mother) 3.2 3.7 13.2 -0.7 0.5 -1.0 -3.6
Alzheimer’s Disease (in father) 0.5 0.5 1.0 -0.2 0.6 1.0 -0.8
Alzheimer’s Disease (including proxy) 3.0 4.4 15.7 0.1 1.4 -0.3 -4.0
Crohns Disease (2017) 2.1 4.6 15.1 1.7 0.2 -3.9 0.7
Irritable Bowel Disease (IBD) 1.0 2.3 5.4 1.7 0.6 -2.3 0.8
Ulcerative Colitis (UC) 0.2 0.3 1.0 1.0 0.4 0.1 0.1
Major Depression (MDD) 0.5 0.6 1.5 -0.3 -1.2 -0.5 0.9
Reaction Time 0.5 0.9 3.3 1.8 0.2 -0.4 0.4
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.7 -0.3 -0.4 -1.3 0.8
Breast Cancer 0.2 0.5 1.1 1.1 0.6 0.6 0.3
Ovarian Cancer 0.8 1.0 2.4 -0.6 -1.2 0.2 1.6
Prostate Cancer 0.7 1.0 3.2 -0.0 -0.2 0.8 -1.8
Age at First Birth 1.4 2.0 6.4 -0.5 1.0 2.5 -0.7
Bipolar Disorder (2011) 3.2 3.1 8.0 -1.6 -0.6 1.2 -2.8
Body Mass Index (BMI) (2010) 0.1 0.2 0.2 0.4 -0.3 -0.4 -0.5
Coronary Artery Disease (CAD) 0.8 1.0 2.1 -1.4 -1.3 -0.1 0.5
Crohns Disease (2012) 1.1 1.8 6.8 0.4 -0.6 -2.6 0.1
Mean Putamen Volume 1.6 1.8 3.3 -1.8 -1.5 -1.1 -0.5
Fasting Glucose 1.2 1.5 4.1 0.9 1.0 -0.0 2.0
HbA1C 1.0 1.1 2.7 0.2 1.2 -1.6 0.4
HDL Cholesterol 0.9 1.6 2.7 1.6 0.0 1.4 1.3
LDL Cholesterol 1.3 2.1 5.0 0.1 1.0 -2.2 -1.5
Lupus 1.5 2.3 7.0 1.0 1.0 2.6 -0.4
Neuroticism (2016) 1.7 2.4 7.1 0.8 0.9 -2.7 -1.0
Primary Biliary Cirrhosis 0.3 0.4 0.6 -0.0 -0.7 0.7 -0.6
Rheumatoid Arthritis 1.0 1.3 2.6 -0.6 -1.3 0.8 1.6
Schizophrenia (2014) 1.2 2.6 7.6 2.8 0.9 -0.2 1.4
Triglycerides 0.2 0.3 0.6 -0.4 0.4 -0.8 -0.5
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.8 0.9 -0.3 0.2 0.7
Ulcerative Colitis 0.6 0.8 2.3 0.4 0.7 1.5 0.6
Blood Eosinophil Count 0.2 1.8 3.5 0.2 -1.9 -1.7 0.9
Blood Platelet Count 1.5 17.0 53.1 -1.9 -3.3 7.3 0.1
Blood Red Count 0.1 1.4 3.7 1.1 0.7 -1.9 0.5
Blood White Count 0.2 1.2 3.7 0.1 -0.7 1.9 -0.7
Heel T-Score 0.5 4.1 7.8 1.4 2.3 -1.1 -2.8
BMI 0.5 2.8 4.2 2.0 -1.4 -2.0 0.8
Height 0.3 5.2 12.4 -3.5 0.6 2.2 1.8
Waist Hip Ratio (WHR) 0.5 2.2 4.0 0.6 1.8 2.0 -1.1
Systolic Blood Pressure 0.1 0.3 0.5 0.5 0.4 0.7 -0.4
Smoking Status 0.5 1.1 2.9 1.3 0.0 -1.7 -0.0
Allergy or Eczema 0.0 0.1 0.2 -0.2 0.5 0.1 -0.2
Cardiovascular Disease 0.3 0.9 1.7 -1.3 -1.1 -0.4 -0.8
Hypothyroidism (self reported) 0.1 0.3 0.7 0.2 -0.8 0.5 0.3
Respiratory disease 0.3 0.6 1.7 -1.3 -0.7 -0.5 -0.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.5 0.4 -0.5 -0.7 -0.5
Lung FEV1/FVC ratio 0.4 2.2 3.7 -1.9 -1.1 1.3 -1.5
Lung FVC 0.2 1.0 2.5 0.7 0.1 1.1 1.6
Neuroticism 1.3 3.1 4.7 -2.0 -2.2 -1.6 -1.0
Chronotype (morning person) 0.7 1.6 4.1 -1.4 -2.0 -0.1 0.5
Hair Pigment 0.0 1.0 3.2 0.4 0.3 1.8 -0.7
Tanning 0.1 1.7 6.1 -0.3 -0.6 2.5 -0.2
Hand grip strength (left) 0.4 1.0 2.2 -1.1 -0.4 1.5 0.6
Number of treatments/medications taken 0.5 0.9 1.8 0.2 -1.3 -0.5 1.4
Average weekly spirits intake 0.6 0.8 2.2 -0.1 -0.2 -0.9 1.5
Sensitivity / hurt feelings 0.3 0.6 1.0 -0.2 0.7 -1.0 -0.9
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.8 -0.5 -0.4 -0.9 -1.4
Hearing difficulty/problems: Yes 2.3 3.5 7.6 -2.8 -2.0 -1.7 0.2
Relative age of first facial hair 1.9 4.0 8.7 -1.8 -2.9 -1.8 0.9
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.7 -0.2 -0.8 0.2 0.2
Ever used hormone-replacement therapy (HRT) 1.4 1.8 4.9 1.2 0.3 -0.9 2.2
Ever had hysterectomy (womb removed) 0.7 0.8 1.6 0.6 0.3 -1.3 -1.0
Systolic blood pressure, automated reading 0.2 0.6 0.8 0.4 -0.8 -0.9 0.8
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.0 0.8 0.4 -0.4 -1.4
Angina 0.4 0.5 2.1 0.1 -0.0 -0.1 -1.5
Medication for hormone replacement therapy 0.6 0.7 1.6 0.8 0.4 -0.4 1.3
Vitamin and mineral supplements 0.3 0.4 1.2 0.2 -0.0 -0.5 1.1
Supplements: Zinc 0.4 0.4 1.0 -0.5 0.7 1.0 0.1
Medication: Co-codamol 1.4 1.6 3.2 -0.8 -1.8 -0.4 1.6
Medication: Metformin 0.3 0.4 1.0 0.6 -0.5 -0.3 -1.0
Diabetes (father) 1.9 2.4 4.6 -2.1 -0.8 1.3 -1.6
Diabetes (mother) 0.7 0.8 2.0 -1.0 -1.4 0.2 -0.6
Severe depression (siblings) 0.7 0.8 2.0 1.4 0.2 1.0 0.4
Pack years adult smoking proportion 0.5 0.7 1.7 1.0 0.2 -0.4 1.3
Impedance of leg (right) 0.4 2.1 6.7 -2.6 -0.5 1.1 0.1
Leg fat-free mass (left) 0.1 0.5 1.3 0.4 0.7 -0.5 -1.1
Trunk fat percentage 0.2 0.7 2.1 0.6 -0.6 -1.5 0.2
Hand grip strength (right) 0.8 2.1 5.2 -2.3 -0.3 1.8 -0.0
Townsend deprivation index at recruitment 2.4 3.4 10.5 -1.0 -0.6 -1.4 -3.2
Current tobacco smoking 0.8 1.4 2.4 1.2 -1.6 -0.9 0.8
Average weekly fortified wine intake 0.3 0.4 1.1 0.5 -0.2 -0.4 1.1
Maternal smoking around birth 0.4 0.6 1.6 1.3 -0.5 -0.2 -0.6
Fed-up feelings 4.0 7.3 9.5 -2.8 -2.9 -1.8 -3.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.3 0.1 -0.2 -0.6 -0.6
Relative age voice broke 0.8 1.2 2.3 -0.5 -1.4 -1.5 0.4
Taking other prescription medications 0.0 0.1 0.2 0.4 -0.3 -0.1 -0.0
Age when periods started (menarche) 2.1 5.1 17.8 -0.7 1.4 0.0 4.2
Bilateral oophorectomy (both ovaries removed) 2.1 2.4 5.7 0.2 0.8 2.4 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 1.9 1.2 1.3 -1.4 -0.7
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.3 -0.0 -0.9 -1.1 -0.3
Qualifications: CSEs or equivalent 0.2 0.3 1.0 -0.1 -0.5 0.1 -1.0
Serious illness, injury or assault to yourself 0.5 0.6 1.6 1.3 0.2 -0.6 -0.5
High blood pressure 0.2 0.7 2.2 0.1 -1.5 -0.6 -0.1
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.4 -0.0 0.6 0.5 -0.3
Multivitamins +/- minerals 0.2 0.3 0.4 -0.7 -0.3 -0.4 -0.7
Stomach or abdominal pain in last month 1.5 1.9 4.1 -2.0 -1.4 -0.2 -1.3
Supplements: Glucosamine 0.2 0.2 0.5 -0.3 0.7 0.5 0.4
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 2.6 -1.5 -1.0 1.6 0.6
Medication: Atenolol 0.6 0.8 2.8 0.3 -0.3 0.5 -1.7
Medication: Levothyroxine sodium 0.4 0.7 1.6 0.9 -0.1 1.3 0.6
Sitting height 0.7 5.2 10.6 -3.3 1.0 3.0 -0.7
Chronic bronchitis/emphysema (father) 1.2 1.4 2.6 0.1 -0.9 -1.4 1.6
High blood pressure (mother) 1.5 2.2 4.0 -1.9 -2.0 0.0 -1.0
Body mass index (BMI) 0.4 1.8 3.1 1.8 -1.0 -1.7 0.4
Impedance of leg (left) 0.5 2.5 7.6 -2.8 -1.0 1.0 0.6
Leg predicted mass (left) 0.1 0.6 1.4 0.4 0.8 -0.5 -1.2
Trunk fat mass 0.1 0.4 1.5 0.4 -0.3 -1.2 0.0
Waist circumference 0.3 1.0 2.2 1.5 0.3 -1.3 -0.2
Number of incorrect matches in round 2.2 3.7 5.7 2.1 2.4 -1.6 -1.4
Past tobacco smoking 0.7 1.3 4.7 -0.5 -0.2 2.2 0.2
Alcohol usually taken with meals 0.3 0.5 1.6 -0.3 0.3 1.3 0.6
Nervous feelings 0.7 1.2 2.4 -1.1 -1.6 -0.4 1.0
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 3.6 -1.4 -1.8 -1.2 -1.9
Hearing difficulty/problems with background noise 0.3 0.5 1.3 -0.8 -0.5 -1.1 0.1
Hair/balding pattern: Pattern 2 1.4 1.8 3.6 1.9 1.4 -1.1 -0.5
Had menopause 2.4 3.1 8.6 1.2 -0.8 -1.2 2.9
Had other major operations 1.1 1.3 2.8 -1.2 -1.0 1.7 -0.2
Forced vital capacity (FVC) 0.5 1.9 4.0 -2.0 0.1 1.8 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 3.1 0.8 1.6 -1.8 -0.9
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.6 0.2 -0.3 -1.6 -1.3
Qualifications: None of the above 0.5 1.0 1.7 -0.7 -1.3 -0.7 1.2
Financial difficulties in last 2 years 0.6 0.8 2.9 -0.2 0.2 0.6 -1.7
Mouth/teeth dental problems 0.4 0.6 1.6 0.5 0.8 0.3 -1.2
Heart attack 0.3 0.4 0.9 0.2 1.0 0.7 -0.2
Allergy 0.3 0.7 2.2 1.5 0.7 -0.3 0.6
Pain all over the body in last month 0.9 1.0 1.4 -0.6 -1.2 0.9 1.2
Diabetes (self-reported) 0.5 0.8 2.4 0.7 -0.0 -1.6 -0.5
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.1 1.1 1.0 0.7 -0.4
Medication: Ramipril 0.5 0.7 1.9 0.8 -0.4 -0.1 1.4
Medication: Simvastatin 0.3 0.4 1.0 0.7 1.0 -0.1 0.2
Fluid intelligence score 0.3 0.7 1.3 -1.0 -0.3 -1.1 -0.6
Illnesses of siblings 0.3 0.4 1.3 -0.4 -0.1 0.3 1.2
Neuroticism score 1.5 3.2 4.6 -2.1 -1.6 -1.7 -1.6
Weight 0.0 0.2 0.7 0.4 -0.2 -0.9 -0.2
Impedance of arm (right) 0.2 0.9 3.1 -1.8 -0.1 0.7 -0.1
Arm fat percentage (right) 0.3 1.0 1.3 1.1 -1.0 -1.1 0.8
Trunk fat-free mass 0.1 0.4 0.8 -0.3 0.8 -0.1 -0.9
Hip circumference 0.3 1.4 4.1 1.0 -0.8 -2.0 0.2
Time employed in main current job 0.8 0.9 1.8 -0.8 -1.1 -0.3 1.3
Alcohol intake versus 10 years previously 0.4 0.6 1.2 0.4 1.1 0.4 -0.9
Father’s age at death 0.4 0.5 0.6 -0.8 0.6 0.8 0.5
Worrier / anxious feelings 0.3 0.5 1.4 -0.4 0.2 -0.6 -1.2
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 4.8 -1.0 -2.2 -1.1 -0.5
Falls in the last year 1.0 1.3 3.2 -1.1 -1.8 0.9 -0.4
Hair/balding pattern: Pattern 3 0.3 0.5 0.7 -0.4 -0.7 -0.8 0.7
Number of live births 0.7 1.0 2.5 1.2 0.0 0.1 1.6
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 5.6 -2.0 0.5 2.4 -0.9
Pulse rate 1.1 1.9 3.7 -1.9 -1.8 0.4 -0.9
Happiness 3.1 3.8 9.7 -2.1 -1.0 -0.2 -3.1
Noisy workplace 0.2 0.2 0.4 -0.6 -0.4 -0.6 -0.2
Qualifications: A levels/AS levels or equivalent 1.1 2.4 4.7 1.4 2.2 1.6 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 1.5 -1.2 -0.8 -0.7 -1.2
Mouth/teeth dental problems: Dentures 0.9 1.5 4.0 -0.1 -0.3 -1.4 2.0
Asthma 0.8 1.5 4.2 -2.0 -0.9 -0.1 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.6 -1.6 -0.7 0.6 -0.7
Medication: Cholesterol lowering 0.5 0.7 1.9 0.8 1.4 -0.3 -0.6
Depression (self-reported) 0.1 0.1 0.4 -0.1 -0.6 0.3 -0.0
Medication: Lansoprazole 3.3 3.8 6.3 1.7 0.2 2.5 2.5
Prospective memory result 0.1 0.1 0.2 -0.4 0.1 -0.2 -0.4
Lung cancer (father) 1.6 1.9 5.7 0.2 -0.1 -2.4 -1.4
Illnesses of mother 1.5 1.9 3.7 1.3 1.9 1.1 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 5.5 -2.3 -0.0 2.0 -1.1
Pulse wave Arterial Stiffness index 1.3 1.6 3.4 1.9 0.5 1.6 -0.1
Impedance of arm (left) 0.2 1.0 2.3 -1.5 0.5 1.0 -0.8
Arm fat mass (right) 0.1 0.5 1.0 0.9 -0.6 -1.0 0.2
Trunk predicted mass 0.1 0.4 0.7 -0.2 0.8 -0.1 -0.9
Standing height 0.4 4.0 7.7 -2.8 1.8 1.6 -1.5
Length of working week for main job 2.6 2.9 4.6 -1.5 -2.1 0.0 2.1
Exposure to tobacco smoke at home 1.7 1.9 4.0 -0.8 0.5 -2.0 -1.6
Breastfed as a baby 1.3 1.6 3.3 1.8 0.3 0.6 1.7
Tense / ‘highly strung’ 1.9 3.2 6.9 -2.6 -1.7 -1.4 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.6 0.2 -0.5 -0.0
Hair/balding pattern: Pattern 4 0.5 1.1 1.9 1.4 1.2 0.0 1.1
Birth weight of first child 0.4 0.7 1.3 0.3 -1.1 1.1 -0.5
Peak expiratory flow (PEF) 0.8 1.9 2.6 -1.3 0.9 1.5 -1.6
Pulse wave reflection index 1.2 1.4 2.3 1.5 1.5 0.6 -1.0
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.9 -0.8 -0.3 -1.7 -0.6
Loud music exposure frequency 1.9 2.1 5.3 -1.7 -2.3 0.3 -0.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.1 0.5 1.0 1.0 -0.8
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 2.0 1.4 -0.0 -0.5 -0.2
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.1 0.8 0.1 -0.8
Medication: Paracetamol 1.3 2.1 4.8 -1.4 -2.2 -1.1 0.8
Headache pain in last month 0.2 0.4 0.9 -0.4 0.1 -0.7 -0.9
Medication for cholesterol, blood pressure or diabetes 1.5 2.4 6.6 -1.7 -2.6 -0.3 0.0
Glaucoma (self-reported) 0.1 0.1 0.1 -0.2 -0.1 -0.3 -0.3
Gout (self-reported) 0.6 0.8 1.2 -0.8 0.9 -0.6 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.5 0.7 -0.3 0.7 0.6
Medication: Amlodipine 1.3 1.9 3.4 1.8 1.8 -0.8 0.5
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.9 -1.0 0.4 0.4 -0.2
Birth weight 0.4 0.8 2.4 -1.6 -0.0 -0.5 -0.9
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 -0.4 -0.4 -0.7 0.4
High blood pressure (siblings) 0.3 0.4 1.4 -0.1 -0.5 0.3 -1.2
Forced vital capacity (FVC), Best measure 0.7 2.7 7.5 -2.7 -0.3 1.7 -0.5
Body fat percentage 0.2 0.8 1.9 0.7 -0.8 -1.4 0.5
Leg fat percentage (right) 0.3 1.0 2.0 0.6 -1.2 -1.4 0.5
Arm fat-free mass (right) 0.1 0.3 0.7 -0.2 0.7 -0.1 -0.8
Exposure to tobacco smoke outside home 0.8 1.0 1.8 -1.1 -1.0 -1.3 0.1
Comparative body size at age 10 0.7 1.8 4.4 1.3 1.0 -2.1 0.3
Number of full brothers 0.5 0.6 2.1 0.2 -0.4 -1.5 0.2
Worry too long after embarrassment 0.2 0.3 1.1 1.0 -0.2 0.2 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.1 0.9 0.3 -1.1 0.5
Wheeze or whistling in the chest in last year 1.3 2.4 4.9 -2.2 -1.6 -1.1 -0.9
Number of children fathered 0.8 0.9 3.0 -0.6 -0.2 -0.0 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.6 0.7 -0.7 -1.3 0.8
Age at first live birth 0.9 1.7 2.8 1.2 1.6 1.7 0.1
Pulse wave peak to peak time 1.5 1.8 4.5 -2.1 -0.5 -1.5 -0.0
Health satisfaction 2.6 3.3 8.0 -1.9 -2.8 -0.7 -1.1
Shortness of breath walking on level ground 0.6 0.7 1.4 -1.2 -1.1 -0.0 -0.5
Qualifications: College or University degree 1.2 3.9 5.9 2.2 2.4 2.1 0.8
Eye problems/disorders: None of the above 0.3 0.4 0.8 -0.8 0.9 0.0 -0.3
Mouth/teeth dental problems: Loose teeth 1.6 1.9 4.9 1.4 2.2 -0.2 -0.7
Emphysema/chronic bronchitis 0.4 0.5 0.9 0.3 -1.0 -0.7 0.5
Medication for pain relief, constipation, heartburn 1.5 2.5 5.3 2.1 2.3 0.7 0.2
Neck or shoulder pain in last month 1.1 1.5 3.7 -0.8 0.5 -1.2 -1.9
Medication: Blood pressure 1.6 2.8 5.6 2.4 2.3 0.0 0.7
Angina (self-reported) 0.5 0.7 2.7 0.1 -0.0 0.2 -1.6
Migraine (self-reported) 0.9 1.2 3.3 1.0 -0.4 0.4 1.8
Medication: Ibuprofen 1.4 1.7 3.8 -2.0 -1.4 0.8 -0.7
Medication: Allopurinol 1.4 1.8 4.5 1.7 2.1 -0.3 -0.1
Medication: Omeprazole 0.7 0.8 1.9 -0.9 -1.4 -0.7 -0.0
Medication: Seretide 50 evohaler 0.7 0.8 1.7 1.3 0.9 0.9 -0.1
Mean time to correctly identify matches 1.8 3.3 8.1 2.8 1.0 -1.7 1.2
Heart disease (mother) 1.5 1.9 3.9 -0.5 -1.7 -2.0 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.6 0.4 0.3 -2.1 -0.6
Whole body fat mass 0.1 0.5 1.5 0.5 -0.6 -1.2 0.2
Leg fat mass (right) 0.1 0.6 1.3 0.6 -0.7 -1.1 0.3
Arm predicted mass (right) 0.0 0.2 0.5 -0.3 0.3 -0.2 -0.7
Pulse rate, automated reading 0.9 3.0 7.5 -1.9 -2.7 -0.7 -0.8
Alcohol intake frequency. 0.8 1.8 5.6 0.4 -1.2 -2.4 0.2
Comparative height size at age 10 0.5 2.9 5.5 -2.1 1.2 -0.2 -2.3
Number of full sisters 1.3 1.5 3.8 -0.2 0.6 -1.4 -2.0
Suffer from ‘nerves’ 2.8 4.3 9.2 -2.7 -3.0 -0.5 -0.8
Overall health rating 1.8 4.0 6.8 -2.5 -2.6 -0.2 -1.6
Chest pain or discomfort 0.1 0.1 0.3 0.1 -0.0 0.2 0.5
Had major operations 0.2 0.3 0.4 -0.3 -0.5 -0.6 -0.6
Age at last live birth 1.9 2.8 5.6 2.4 2.1 0.6 0.9
Family relationship satisfaction 0.4 0.5 1.0 1.0 0.2 0.3 -0.9
Leg pain on walking 0.5 0.7 1.5 -0.1 -0.1 -1.2 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.9 0.3 -0.8 -1.4 -0.1
Commuting to job workplace: Car/motor vehicle 1.1 1.2 4.1 0.1 -0.8 0.4 2.0
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.7 1.7 0.3 -0.2 1.0
Medication: Aspirin 0.3 0.4 1.2 0.1 -0.4 0.4 1.1
Supplements: Vitamin C 1.5 1.8 3.9 1.0 1.5 2.0 0.0
Knee pain experienced in last month 0.3 0.4 0.9 0.1 0.7 -0.9 -0.6
Hypertension (Self-reported) 0.1 0.3 0.9 0.4 -0.9 -0.4 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.9 -0.2 -0.6 1.0 1.4
Illnesses of father: Heart disease 0.1 0.2 0.4 0.1 0.5 0.7 -0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.6 0.8 -0.1 -0.2 -0.4
Smoking status: Previous 0.6 0.9 2.0 0.4 1.1 -1.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.8 7.3 -1.2 1.3 2.7 -0.9
Whole body fat-free mass 0.1 0.4 0.8 -0.0 0.7 -0.3 -0.9
Leg fat-free mass (right) 0.1 0.3 0.7 0.3 0.5 -0.5 -0.8
Arm fat percentage (left) 0.2 0.8 1.5 1.2 -0.8 -1.0 0.5
Average weekly red wine intake 0.4 0.6 1.7 1.3 0.1 0.8 0.5
Handedness (chirality/laterality): Left-handed 1.2 1.4 3.1 -1.8 -0.9 1.0 -0.7
Mood swings 1.1 1.9 3.1 -1.3 -1.6 -0.6 -1.8
Loneliness, isolation 1.0 1.4 3.3 -1.0 -0.1 -1.2 -1.8
Long-standing illness, disability or infirmity 0.5 0.8 1.7 0.2 -0.2 -1.3 -1.2
Ever had bowel cancer screening 0.0 0.0 0.1 -0.1 0.1 0.3 0.1
Diabetes diagnosed by doctor 0.8 1.2 4.2 0.6 -0.4 -2.0 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.2 3.0 -1.6 -1.7 -0.8 -1.6
Friendships satisfaction 0.7 0.9 1.3 0.2 1.0 1.2 -1.1
Qualifications: nursing, teaching 0.7 1.1 2.9 0.3 1.1 0.5 -1.7
Commuting to job workplace: Walk 1.5 1.6 3.3 -0.4 0.3 -1.8 -1.7
Eye problems/disorders: Cataract 1.2 1.4 3.2 -0.8 -1.8 0.9 1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.4 -0.4 -0.4 1.0 1.2
Medication for cholesterol 0.8 1.1 1.7 0.7 1.3 1.2 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 0.3 0.9 0.5 0.3
Back pain experienced in last month 1.4 2.0 5.4 -1.0 0.2 -1.3 -2.3
Mineral and other dietary supplements 0.5 0.7 2.5 -0.4 -0.1 0.1 -1.6
Breast cancer (self-reported) 1.1 1.3 3.2 -1.1 -0.6 0.4 -1.8
Asthma (self-reported) 1.2 2.3 6.2 -2.5 -1.2 -0.1 -1.2
Osteoporosis (self-reported) 1.1 1.4 3.6 1.3 -0.3 0.4 1.9
Osteoarthritis (self-reported) 0.7 1.0 3.3 0.7 -0.1 -1.8 -0.2
Medication: Aspirin 0.2 0.2 0.5 0.2 -0.1 0.5 0.7
Medication: Gliclazide 2.1 2.3 5.9 -0.5 -1.7 -2.4 0.3
Illnesses of father: None of the above (group 1) 1.3 1.6 4.7 2.2 1.0 -0.6 0.6
Smoking status: Current 0.8 1.3 2.2 1.2 -1.5 -0.8 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.6 -0.9 -0.4 1.9 -0.3
Whole body water mass 0.1 0.3 0.8 -0.1 0.7 -0.1 -0.9
Leg predicted mass (right) 0.1 0.3 0.7 0.3 0.5 -0.5 -0.8
Arm fat mass (left) 0.1 0.5 0.8 0.9 -0.5 -0.9 -0.0
Number of self-reported non-cancer illnesses 1.1 1.8 4.8 -0.5 -2.2 -1.4 -0.4
Average weekly champagne plus white wine intake 0.7 0.9 3.4 0.3 -0.1 0.4 -1.8
Miserableness 1.2 2.1 3.0 -0.9 -1.7 -1.7 -1.3
Guilty feelings 0.4 0.5 1.2 -0.1 0.1 -1.1 -0.9
Wears glasses or contact lenses 0.5 0.5 1.1 -0.4 -0.6 -1.0 -0.7
Ever taken oral contraceptive pill 2.4 2.7 7.4 2.7 1.8 0.4 -0.2
Hearing aid user 1.9 2.2 2.9 -1.7 -1.6 1.0 1.5
Mother’s age at death 0.6 0.8 2.3 -0.1 1.5 0.6 -0.5
Financial situation satisfaction 2.0 2.4 5.3 1.2 2.3 0.9 -1.5
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.8 -0.9 -0.3 -0.8 -0.8
Commuting to job workplace: Public transport 1.6 1.9 3.8 -0.1 1.2 1.5 -2.0
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 0.7 0.1 -0.8 0.4
Medication: Blood pressure 0.6 1.1 3.7 -0.6 -1.9 0.0 -0.5
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.0 1.1 -0.7 -1.2 1.4
Supplements: Fish oil (including cod liver oil) 1.1 1.4 4.0 -0.0 -1.0 -0.8 2.0
High cholesterol (Self-reported) 0.3 0.6 1.9 -1.4 0.3 -0.4 -0.4
Medication: Bendroflumethiazide 0.1 0.2 0.4 -0.6 -0.4 -0.1 -0.6
Medication: Paracetamol 1.8 2.7 6.1 -1.9 -2.5 -1.0 0.5
Medication: Lisinopril 1.0 1.4 4.3 0.9 -0.5 -0.3 2.1
Medication: Atorvastatin 1.3 1.6 4.8 0.7 1.1 -2.2 -0.2
Illnesses of father: High blood pressure 1.2 1.5 3.0 -1.6 -0.1 0.6 -1.7
Alcohol drinker status: Never 0.6 0.7 1.6 1.3 -0.8 -0.5 0.5
Ever smoked 0.7 1.3 4.7 -0.2 -0.3 -2.2 -0.6
Basal metabolic rate 0.0 0.3 0.7 -0.0 0.5 -0.4 -0.8
Leg fat percentage (left) 0.4 1.5 2.9 0.4 -1.5 -1.7 0.7
Arm fat-free mass (left) 0.0 0.2 0.4 -0.5 0.1 -0.3 -0.7
Number of operations (self-reported) 0.8 1.2 2.9 -1.0 -0.6 0.9 -1.7
Average weekly beer plus cider intake 0.5 0.7 1.3 -0.6 -1.0 -1.1 -0.1
Irritability 1.3 2.3 4.2 -1.5 -1.4 -2.0 -0.9
Risk taking 1.7 2.4 5.0 0.8 1.5 -1.4 -2.2
Ever had prostate specific antigen (PSA) test 2.3 2.7 4.2 -2.0 -0.9 1.2 -2.0
Fractured/broken bones in last 5 years 0.3 0.3 0.9 1.0 0.4 0.0 -0.4
Age started oral contraceptive pill 1.2 1.5 4.0 0.8 0.7 -2.0 -0.9
Diastolic blood pressure, automated reading 0.3 1.0 3.1 -0.9 -1.8 -0.5 -0.1
Ever depressed for a whole week 0.9 1.1 2.5 -0.3 -1.3 -1.6 -0.3
Unable to work because of sickness or disability 0.1 0.1 0.3 0.1 -0.3 0.5 0.3
Commuting to job workplace: Cycle 0.3 0.3 0.5 -0.6 0.7 0.5 -0.3
Myopia 0.7 1.1 1.6 -0.9 1.0 1.2 -0.9
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.7 -0.2 0.8 0.4 0.4
Cholesterol lowering medication 1.2 1.8 6.2 -0.9 -0.4 -2.5 0.5
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.8 -0.7 -1.0 -1.7 -0.1
Pain experienced in last month 1.1 1.8 2.7 1.3 -0.7 1.6 1.5
Supplements: Calcium 1.7 1.9 3.4 1.8 1.4 -0.4 1.5
Basal cell carcinoma (self-reported) 1.0 1.2 2.6 -1.6 -1.0 0.9 0.4
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.7 -0.0 0.8 0.7 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.8 -0.1 0.9 0.3 -0.9
Heart disease (siblings) 1.1 1.3 3.1 -0.5 0.7 -1.2 -1.8
Alcohol drinker status: Previous 1.6 1.8 3.8 1.9 0.6 -1.7 -0.2
Pack years of smoking 0.7 1.1 1.9 1.4 0.8 -0.3 1.3
Impedance of whole body 0.3 1.6 5.1 -2.3 0.0 1.0 -0.5
Leg fat mass (left) 0.2 0.7 1.6 0.4 -1.0 -1.3 0.4
Arm predicted mass (left) 0.0 0.1 0.2 -0.1 0.4 -0.3 -0.4