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chr17:32,870,849-34,480,526

Best TWAS P=3.14e-82 · Best GWAS P=2.49e-167 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AP2B1	0.08	0.10	bslmm	445	0.08	3.4e-10	-6.7524	-8.0	1.0e-15	-0.25	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PEX12	0.06	0.00	bslmm	420	0.01	2.8e-02	17.1071	-14.3	1.7e-46	-0.57	0.14	0.42	FALSE
3	GTEx	Adipose Subcutaneous	RASL10B	0.10	0.04	enet	10	0.04	1.8e-04	-6.7353	-7.4	1.3e-13	-0.26	0.82	0.12	FALSE
4	GTEx	Adipose Visceral Omentum	RASL10B	0.11	0.05	lasso	3	0.02	2.7e-02	-7.0703	-7.1	1.3e-12	-0.18	0.36	0.10	FALSE
5	GTEx	Adrenal Gland	RASL10B	0.18	-0.01	enet	18	0.00	2.8e-01	5.6018	6.1	1.1e-09	0.18	0.08	0.06	FALSE
6	GTEx	Brain Caudate basal ganglia	PEX12	0.38	0.02	lasso	9	0.05	1.4e-02	-6.7283	-19.2	3.1e-82	-0.60	0.03	0.67	TRUE
7	GTEx	Brain Cortex	AC015849.19	0.17	0.06	lasso	3	0.07	6.0e-03	1.5858	16.6	1.4e-61	0.62	0.01	0.85	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	RP11-686D22.4	0.35	0.03	enet	18	0.14	1.4e-04	5.4866	9.2	3.6e-20	0.51	0.07	0.63	TRUE
9	GTEx	Breast Mammary Tissue	RP11-686D22.4	0.29	0.13	enet	18	0.11	2.0e-06	3.4517	10.2	1.2e-24	0.23	0.84	0.02	FALSE
10	GTEx	Breast Mammary Tissue (Male)	SLFN5	0.09	0.04	lasso	1	0.03	5.7e-02	10.9911	-11.0	4.2e-28	-0.72	0.03	0.16	FALSE
11	GTEx	Breast Mammary Tissue (Male)	SLFN12	0.33	0.02	lasso	6	0.09	4.8e-03	5.0178	5.2	2.0e-07	0.10	0.03	0.23	FALSE
12	GTEx	Colon Transverse	MMP28	0.10	0.03	enet	9	0.03	1.5e-02	4.1817	8.0	1.9e-15	0.13	0.44	0.02	FALSE
13	GTEx	Esophagus Muscularis	TAF15	0.17	0.13	lasso	10	0.11	2.1e-07	5.6018	-5.3	1.1e-07	-0.08	1.00	0.00	FALSE
14	GTEx	Muscle Skeletal	RASL10B	0.05	0.04	enet	11	0.06	1.2e-06	2.7392	5.9	3.9e-09	0.18	0.70	0.02	TRUE
15	GTEx	Skin Sun Exposed Lower leg	SLFN12	0.19	0.13	enet	16	0.11	2.3e-09	5.0178	5.8	7.3e-09	0.05	1.00	0.00	FALSE
16	GTEx	Stomach	SLFN12	0.29	0.18	lasso	5	0.18	7.7e-09	5.0178	5.3	1.4e-07	0.05	0.95	0.00	FALSE
17	GTEx	Testis	AP2B1	0.29	0.13	lasso	5	0.15	4.6e-07	-7.0433	-7.6	2.6e-14	-0.20	0.97	0.01	FALSE
18	GTEx	Thyroid	RASL10B	0.11	0.18	lasso	1	0.18	1.1e-13	-8.2253	8.2	1.9e-16	0.23	1.00	0.00	FALSE
19	GTEx	Whole Blood	SLFN12	0.18	0.05	enet	22	0.11	3.0e-10	4.3533	7.1	9.5e-13	0.12	0.74	0.02	FALSE
20	METSIM	Adipose	AP2B1	0.05	0.00	bslmm	447	0.02	1.9e-04	-1.1953	-6.2	7.6e-10	-0.29	0.09	0.13	FALSE
21	METSIM	Adipose	RASL10B	0.07	0.04	enet	29	0.04	1.8e-06	-7.0286	-5.2	2.6e-07	-0.16	1.00	0.00	TRUE
22	METSIM	Adipose	RP11-686D22.4	0.19	0.04	bslmm	366	0.08	1.2e-11	5.0178	9.4	5.5e-21	0.17	0.78	0.06	FALSE
23	NTR	Blood	SLFN12L	0.10	0.03	blup	417	0.06	1.3e-17	-0.0074	-9.1	8.0e-20	-0.28	1.00	0.00	FALSE
24	NTR	Blood	SLFN13	0.06	0.01	blup	375	0.03	2.2e-11	-7.0703	-10.5	9.3e-26	-0.39	0.98	0.01	TRUE
25	NTR	Blood	SLFN14	0.01	0.01	bslmm	402	0.00	1.2e-02	-10.2149	7.9	2.6e-15	0.36	0.65	0.03	TRUE
26	YFS	Blood	AP2B1	0.02	0.01	bslmm	422	0.01	9.5e-05	17.1521	-14.3	3.4e-46	-0.56	0.94	0.05	FALSE
27	YFS	Blood	RASL10B	0.02	0.00	bslmm	362	0.01	4.0e-03	1.9202	-8.0	1.1e-15	-0.24	0.07	0.04	TRUE
28	YFS	Blood	SLFN13	0.27	0.08	bslmm	367	0.17	1.6e-52	-4.6882	-6.2	4.8e-10	-0.27	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SLFN12	0.07	0.04	lasso	5	0.02	9.2e-03	5.0178	5.2	1.8e-07	0.04	0.00	0.90	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	RDM1	0.06	0.03	lasso	3	0.04	7.4e-08	3.7851	-5.5	3.8e-08	-0.13	0.01	0.50	TRUE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	PEX12	0.13	0.02	blup	41	0.02	2.9e-02	5.4496	-15.8	2.4e-56	-0.61	0.03	0.17	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	RDM1	0.08	0.02	blup	24	0.03	8.2e-03	4.1732	-5.2	2.2e-07	-0.19	0.00	0.08	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	SLFN14	0.05	0.01	blup	45	0.02	2.2e-02	0.3916	-10.1	4.2e-24	-0.35	0.02	0.06	TRUE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RDM1	0.06	0.01	lasso	4	0.02	2.7e-03	3.7851	-5.5	3.6e-08	-0.12	0.00	0.22	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLFN12	0.04	0.01	blup	50	0.01	1.1e-02	-0.9399	5.7	1.1e-08	0.13	0.00	0.32	TRUE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	AP2B1	0.02	0.02	lasso	1	0.02	4.8e-03	-6.7283	-6.7	1.7e-11	-0.18	0.17	0.02	TRUE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RASL10B	0.06	0.07	lasso	3	0.06	2.9e-03	-11.1384	11.1	8.2e-29	0.46	0.02	0.14	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	RDM1	0.21	0.19	blup	24	0.12	1.2e-03	4.1732	-5.2	2.0e-07	-0.18	0.00	0.08	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PEX12	0.32	0.02	blup	41	0.06	4.9e-03	5.4866	-9.3	1.0e-20	-0.10	0.01	0.08	TRUE