Hub : Genes

SLFN12L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.1002 0.0222 4.5e-12 0.031 0.056 0.044 0.052 0.040 2.7e-10 1.3e-17 5.5e-14 2.3e-16 6.7e-13
2 TCGA Breast Invasive Carcinoma 0.0549 0.0206 9.5e-08 0.028 0.030 0.040 NA 0.038 1.6e-06 7.9e-07 1.1e-08 NA 3.0e-08
3 TCGA Head and Neck Squamous Cell Carcinoma 0.0321 0.0163 5.0e-03 0.039 0.022 0.028 NA 0.033 2.7e-05 1.6e-03 3.7e-04 NA 1.2e-04
4 TCGA Brain Lower Grade Glioma 0.0388 0.0167 9.0e-04 0.007 0.033 0.008 NA 0.006 4.7e-02 9.8e-05 3.6e-02 NA 6.0e-02
5 TCGA Liver Hepatocellular Carcinoma 0.1340 0.0650 6.1e-03 -0.006 0.059 0.033 NA 0.023 9.2e-01 9.4e-04 1.1e-02 NA 2.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.2 0.6 0.1 0.1 0.6 0.8 -0.2
Bipolar Disorder or Schizophrenia 1.3 3.1 4.2 1.7 2.0 1.8 1.8 1.5
Depressed Affect (Nagel 2018) 1.3 2.7 6.0 0.1 -2.5 -2.3 -1.1 -1.1
Depression (Nagel 2018) 4.0 6.0 11.4 -0.4 -2.7 -3.4 -2.1 -2.6
Intelligence (Savage-Jansen 2018) 0.6 1.7 3.6 1.5 1.2 1.1 0.7 1.9
Neuroticism (Nagel 2018) 0.8 1.8 5.3 -0.1 -2.3 -1.5 -0.7 -0.9
Schizophrenia (2018) 2.0 4.2 6.4 2.2 2.5 1.8 1.6 2.0
Schizophrenia vs Biploar Disorder 0.6 0.8 1.9 -0.1 1.4 1.0 1.0 -0.1
Worry (Nagel 2018) 0.3 0.7 3.2 0.1 -1.8 -0.4 -0.2 -0.5
Alzheimer’s Disease (in mother) 0.7 0.8 2.0 0.3 1.4 -0.0 1.1 1.0
Alzheimer’s Disease (in father) 0.4 0.4 1.1 0.4 0.4 0.0 -1.0 0.7
Alzheimer’s Disease (including proxy) 0.6 0.8 2.3 0.6 1.0 -0.5 -0.3 1.5
Crohns Disease (2017) 0.2 0.5 0.9 0.8 -0.9 0.5 -0.1 0.9
Irritable Bowel Disease (IBD) 0.1 0.2 0.3 -0.0 -0.5 0.5 -0.1 0.5
Ulcerative Colitis (UC) 0.1 0.3 0.8 -0.9 0.2 0.4 -0.3 0.4
Major Depression (MDD) 0.4 0.5 1.8 -1.3 0.3 -0.8 -0.1 -0.5
Reaction Time 1.0 2.0 3.7 0.8 1.5 1.9 1.4 1.2
Verbal and Numeric Reasoning (VNR) 2.3 5.6 12.0 2.9 1.5 2.0 1.2 3.5
Breast Cancer 0.1 0.2 0.6 0.3 0.4 -0.3 -0.8 0.2
Ovarian Cancer 0.9 1.2 2.0 -1.0 -1.4 -1.2 -0.1 -1.2
Prostate Cancer 0.8 1.1 3.5 0.6 -1.9 -0.9 -0.3 0.7
Age at First Birth 4.9 7.1 9.0 2.8 3.0 2.5 2.3 2.6
Bipolar Disorder (2011) 0.2 0.2 0.5 0.1 0.3 0.3 -0.5 0.7
Body Mass Index (BMI) (2010) 0.1 0.2 0.5 0.3 0.6 0.7 0.0 -0.0
Coronary Artery Disease (CAD) 1.2 1.5 4.7 -1.2 0.7 2.2 0.8 0.4
Crohns Disease (2012) 0.2 0.4 0.8 -0.9 -0.8 -0.4 -0.6 0.0
Mean Putamen Volume 1.2 1.4 2.7 0.7 -0.6 1.6 1.3 1.3
Fasting Glucose 0.9 1.1 3.5 -0.3 0.4 -0.2 1.2 -1.9
HbA1C 0.5 0.5 1.5 0.6 1.2 0.6 -0.4 0.4
HDL Cholesterol 0.6 1.0 2.6 -0.2 0.0 1.6 0.7 1.3
LDL Cholesterol 1.3 2.1 5.0 -0.7 -1.1 -0.8 -1.7 -2.2
Lupus 0.1 0.2 0.7 -0.3 0.8 -0.0 -0.2 0.5
Neuroticism (2016) 2.1 3.0 8.1 -0.8 -2.9 -1.9 -1.2 -1.1
Primary Biliary Cirrhosis 0.7 1.1 3.9 -2.0 0.2 1.1 0.3 -0.3
Rheumatoid Arthritis 0.2 0.3 0.5 0.6 0.7 -0.1 -0.2 0.7
Schizophrenia (2014) 1.8 4.0 8.0 1.6 2.8 1.8 2.0 1.5
Triglycerides 1.0 1.6 3.8 -0.1 -1.4 -0.8 -1.3 -1.9
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.1 -1.1 -0.5 1.0 -0.2 -0.0
Ulcerative Colitis 0.3 0.5 2.3 -0.1 1.5 -0.1 0.1 0.4
Blood Eosinophil Count 0.2 1.6 4.0 -1.5 1.0 0.8 2.0 -0.2
Blood Platelet Count 2.2 25.0 83.0 -9.1 2.6 3.9 -3.1 -3.3
Blood Red Count 0.1 1.2 3.7 0.4 -1.1 -0.8 -0.7 -1.9
Blood White Count 0.1 0.4 1.1 -0.4 0.0 0.7 -1.0 -0.6
Heel T-Score 0.1 0.7 2.6 -0.6 0.2 -0.1 0.6 -1.6
BMI 0.5 2.8 5.7 0.1 -2.4 -0.5 -2.2 -1.8
Height 0.1 2.4 7.9 -1.5 2.8 1.2 0.1 -0.0
Waist Hip Ratio (WHR) 0.1 0.5 1.3 -0.8 0.1 -0.8 -1.1 0.4
Systolic Blood Pressure 0.3 1.3 1.7 -1.3 -1.3 -1.2 -0.7 -1.1
Smoking Status 2.0 4.7 8.9 -0.5 -2.8 -3.0 -2.0 -1.4
Allergy or Eczema 0.5 1.2 4.2 0.4 1.0 0.7 0.4 2.1
Cardiovascular Disease 0.2 0.8 1.7 0.1 -1.1 -0.6 -0.9 -1.3
Hypothyroidism (self reported) 1.2 2.7 7.4 -0.4 1.7 1.6 -0.0 2.7
Respiratory disease 0.1 0.3 0.9 0.1 1.0 0.3 -0.6 -0.5
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.1 -1.5 0.5 -0.0 -1.3 -0.8
Lung FEV1/FVC ratio 0.3 1.7 4.5 -0.3 -0.9 -1.8 -2.1 0.2
Lung FVC 0.1 0.4 1.5 -0.3 0.6 -0.0 -0.1 1.2
Neuroticism 0.9 2.2 6.6 0.2 -2.6 -1.7 -1.1 -0.7
Chronotype (morning person) 5.5 12.8 24.0 2.7 2.8 4.9 4.1 2.8
Hair Pigment 0.0 0.4 0.8 -0.6 0.0 0.9 0.6 -0.5
Tanning 0.3 3.6 4.9 1.5 1.8 2.2 2.2 1.7
Hand grip strength (left) 0.7 1.8 5.0 -0.5 0.5 -1.3 -2.2 1.4
Number of treatments/medications taken 0.9 1.6 5.0 -0.3 -0.3 -1.3 -2.2 -1.1
Average weekly spirits intake 0.1 0.1 0.3 -0.3 -0.2 -0.2 0.0 -0.5
Sensitivity / hurt feelings 0.8 1.3 3.6 0.1 -1.9 -1.6 -0.2 -0.8
Frequency of depressed mood in last 2 weeks 2.4 3.4 8.0 1.7 -1.8 -2.8 -1.4 -1.1
Hearing difficulty/problems: Yes 0.3 0.4 0.7 -0.5 -0.8 -0.7 -0.7 -0.1
Relative age of first facial hair 0.1 0.3 0.8 0.1 -0.9 0.5 0.3 -0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.8 0.5 -0.2 -1.0 -1.4 0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.9 -1.4 0.2 1.2 0.7 0.3
Ever had hysterectomy (womb removed) 2.0 2.2 5.9 -2.4 2.0 0.9 0.2 -0.6
Systolic blood pressure, automated reading 0.7 2.1 3.9 -2.0 -1.7 -0.8 -0.4 -1.8
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 4.1 -0.8 0.6 -0.7 -0.0 -2.0
Angina 0.5 0.7 1.9 -0.6 -1.4 -0.2 -0.4 -1.0
Medication for hormone replacement therapy 0.2 0.3 0.6 0.2 -0.1 0.8 0.6 -0.5
Vitamin and mineral supplements 0.4 0.6 2.0 0.2 -1.4 0.6 0.7 0.3
Supplements: Zinc 2.6 2.8 4.8 1.7 -0.8 -2.2 -1.9 1.5
Medication: Co-codamol 0.7 0.8 1.6 -0.6 -0.5 -1.1 -1.3 -0.7
Medication: Metformin 0.3 0.4 1.0 -0.9 0.2 0.2 -0.5 -1.0
Diabetes (father) 1.4 1.7 4.3 1.7 0.8 1.0 -0.0 2.1
Diabetes (mother) 2.1 2.7 3.7 -1.0 -1.9 -1.9 -1.8 -1.4
Severe depression (siblings) 0.3 0.3 1.1 1.0 -0.4 -0.2 -0.2 0.4
Pack years adult smoking proportion 0.6 0.9 2.5 -0.2 -0.9 -1.6 -0.5 -1.0
Impedance of leg (right) 0.3 1.3 2.3 -1.5 -1.5 -1.1 -0.7 -0.5
Leg fat-free mass (left) 0.1 0.7 1.7 0.9 1.3 0.8 -0.4 -0.6
Trunk fat percentage 0.5 2.0 3.9 -1.0 -2.0 -0.3 -1.9 -1.3
Hand grip strength (right) 0.4 1.1 2.7 -0.6 0.1 -1.6 -1.6 -0.2
Townsend deprivation index at recruitment 1.1 1.6 2.8 0.1 -1.6 -1.4 -1.7 -0.7
Current tobacco smoking 0.2 0.4 0.9 0.1 -0.6 -1.0 0.1 -0.8
Average weekly fortified wine intake 0.4 0.5 2.1 -0.6 1.4 0.1 0.1 -0.1
Maternal smoking around birth 0.6 0.9 2.3 1.0 0.7 -1.5 -0.7 0.1
Fed-up feelings 2.2 4.0 9.6 0.3 -3.1 -2.3 -1.9 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.3 4.9 0.0 -1.5 -1.9 -1.0 -2.2
Relative age voice broke 0.3 0.4 1.0 -0.8 -1.0 -0.4 -0.1 -0.4
Taking other prescription medications 1.8 2.8 6.0 -1.5 -1.3 -1.7 -2.4 -1.0
Age when periods started (menarche) 0.2 0.5 2.1 0.5 0.5 0.3 0.3 -1.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.6 -0.7 0.7 0.5 0.1 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.3 0.7 -0.7 -0.4 -0.0 -0.8 -0.6
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 -0.4 0.5 0.5 0.7 -0.3
Qualifications: CSEs or equivalent 0.4 0.5 1.2 -1.1 -0.4 -0.5 -0.2 -1.0
Serious illness, injury or assault to yourself 1.5 1.8 5.0 1.3 -1.0 -2.2 -1.2 -0.2
High blood pressure 0.9 2.5 4.7 -1.1 -1.8 -1.6 -1.0 -2.2
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.1 0.4 0.2 0.4 0.2 1.1
Multivitamins +/- minerals 1.1 1.4 2.9 -0.7 -0.1 -1.7 -1.7 -0.9
Stomach or abdominal pain in last month 0.2 0.3 0.7 0.1 -0.7 0.6 -0.8 -0.1
Supplements: Glucosamine 0.4 0.5 1.7 -1.3 -0.4 0.8 0.0 -0.2
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.9 1.4 -0.0 0.4 1.1 -1.0
Medication: Atenolol 3.2 3.9 5.3 -2.1 -2.3 -2.1 -2.1 -1.0
Medication: Levothyroxine sodium 0.3 0.5 0.7 -0.8 -0.7 -0.1 -0.8 0.8
Sitting height 0.6 3.9 13.0 -0.0 3.6 1.8 -0.3 1.8
Chronic bronchitis/emphysema (father) 3.0 3.5 12.5 -1.5 -1.0 -1.3 0.1 -3.5
High blood pressure (mother) 1.0 1.4 5.3 -0.0 -2.3 -0.9 -1.0 -0.1
Body mass index (BMI) 0.3 1.4 3.1 0.2 -1.8 -0.0 -1.5 -1.2
Impedance of leg (left) 0.3 1.6 2.8 -1.5 -1.7 -1.1 -1.2 -0.1
Leg predicted mass (left) 0.1 0.7 1.8 0.9 1.3 0.8 -0.3 -0.5
Trunk fat mass 0.3 1.3 2.3 -0.6 -1.3 0.1 -1.5 -1.3
Waist circumference 0.2 0.8 1.7 -0.2 -0.9 -0.0 -1.3 -1.2
Number of incorrect matches in round 0.6 1.1 2.7 -1.6 1.3 -0.6 0.7 -0.3
Past tobacco smoking 0.9 1.7 3.0 0.9 0.9 1.7 1.4 1.3
Alcohol usually taken with meals 2.9 4.6 8.3 -0.1 2.1 2.9 2.7 1.8
Nervous feelings 0.2 0.4 1.7 -0.1 -1.3 0.1 0.1 -0.5
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.8 3.4 1.0 -1.7 -1.9 -0.6 -1.1
Hearing difficulty/problems with background noise 0.9 1.4 2.3 -0.8 -1.5 -1.5 -1.5 -0.0
Hair/balding pattern: Pattern 2 0.3 0.3 1.3 -0.2 1.1 0.1 -0.3 0.6
Had menopause 0.6 0.8 1.9 -0.1 -0.3 1.4 0.9 1.0
Had other major operations 0.6 0.7 1.5 -0.3 -1.1 -1.0 -0.1 1.2
Forced vital capacity (FVC) 0.2 0.8 1.7 0.3 0.9 -0.9 -1.3 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.0 -1.2 0.2 0.7 -0.1 -1.4
Ever unenthusiastic/disinterested for a whole week 1.3 1.5 4.4 1.6 0.2 0.8 -0.1 2.1
Qualifications: None of the above 2.9 6.1 8.7 -2.6 -2.4 -2.9 -1.7 -2.6
Financial difficulties in last 2 years 1.2 1.6 5.2 0.6 -2.3 -1.2 -0.6 -0.8
Mouth/teeth dental problems 0.9 1.4 2.9 0.2 1.1 1.7 1.6 0.8
Heart attack 0.3 0.4 0.6 -0.8 -0.7 -0.7 -0.7 -0.3
Allergy 0.2 0.4 0.8 -0.4 -0.9 -0.7 -0.7 -0.1
Pain all over the body in last month 0.2 0.2 0.5 0.7 0.0 0.4 -0.1 0.7
Diabetes (self-reported) 0.2 0.4 1.0 -1.0 -0.1 0.2 -0.8 -0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.2 0.8 0.2 0.9 0.3 1.1
Medication: Ramipril 0.1 0.2 0.4 0.0 0.5 0.0 0.7 0.5
Medication: Simvastatin 0.9 1.3 2.4 -0.5 -1.2 -1.4 -0.5 -1.6
Fluid intelligence score 3.0 6.1 12.8 3.6 1.1 2.1 1.1 3.3
Illnesses of siblings 0.2 0.3 1.0 1.0 -0.4 0.6 -0.0 -0.0
Neuroticism score 1.5 3.1 7.4 0.4 -2.7 -2.0 -1.5 -1.2
Weight 0.1 0.6 1.9 -0.1 -0.4 0.2 -1.4 -1.0
Impedance of arm (right) 0.7 3.4 5.5 -2.2 -1.5 -2.3 -1.5 -1.4
Arm fat percentage (right) 0.6 2.4 4.3 -0.7 -2.1 -0.6 -1.8 -1.9
Trunk fat-free mass 0.2 1.1 3.5 0.7 1.9 1.1 0.2 -0.5
Hip circumference 0.3 1.4 3.0 -0.8 -1.3 -0.1 -1.2 -1.7
Time employed in main current job 0.7 0.8 1.6 -0.6 -0.6 -1.2 -0.6 -1.3
Alcohol intake versus 10 years previously 0.8 1.2 2.5 0.9 -1.2 -1.6 -1.1 -0.3
Father’s age at death 3.8 5.1 10.4 0.5 1.7 3.2 1.4 3.1
Worrier / anxious feelings 0.2 0.3 1.2 -0.1 -1.1 0.0 0.2 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 5.0 -0.1 -0.9 -2.2 -0.8 -1.3
Falls in the last year 0.4 0.5 0.8 0.7 -0.9 -0.6 -0.8 -0.1
Hair/balding pattern: Pattern 3 0.3 0.5 1.2 -0.6 0.6 0.3 1.1 0.7
Number of live births 0.3 0.5 1.1 -0.4 -1.0 -0.0 -0.5 -0.9
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 4.4 0.1 0.4 -1.5 -2.1 0.7
Pulse rate 0.7 1.1 2.2 1.5 1.4 0.5 -0.4 1.1
Happiness 1.8 2.2 4.0 1.4 -2.0 -1.5 -1.7 0.5
Noisy workplace 0.2 0.2 0.5 0.3 0.3 -0.6 -0.2 -0.7
Qualifications: A levels/AS levels or equivalent 0.9 2.0 7.2 1.0 2.7 0.9 0.9 0.1
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 5.7 -0.0 2.4 1.3 -0.1 1.4
Mouth/teeth dental problems: Dentures 0.2 0.3 0.9 -0.9 -0.4 0.2 -0.7 -0.3
Asthma 1.0 2.0 3.8 1.6 1.6 1.9 1.0 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 -0.2 0.3 -0.2 -0.5 -0.4
Medication: Cholesterol lowering 0.1 0.2 0.6 -0.5 0.8 0.3 -0.4 -0.1
Depression (self-reported) 2.3 2.8 4.7 0.8 -2.1 -2.2 -1.9 -0.7
Medication: Lansoprazole 1.4 1.6 3.3 -1.8 -0.8 -1.6 -1.2 -0.5
Prospective memory result 0.9 1.1 3.8 -0.1 -0.0 1.3 1.9 -0.0
Lung cancer (father) 2.1 2.5 3.9 -0.6 -2.0 -1.7 -1.2 -2.0
Illnesses of mother 1.2 1.5 3.0 0.1 1.6 1.7 1.2 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.4 0.4 1.1 -0.9 -1.2 0.8
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 -0.4 0.3 -0.6 -0.6 -0.3
Impedance of arm (left) 0.4 1.8 3.7 -1.9 -0.9 -1.7 -0.8 -1.0
Arm fat mass (right) 0.4 1.4 2.4 -0.7 -1.4 -0.0 -1.6 -1.6
Trunk predicted mass 0.2 1.1 3.5 0.7 1.9 1.0 0.2 -0.6
Standing height 0.2 1.9 8.2 -1.0 2.9 0.5 -0.1 0.5
Length of working week for main job 2.0 2.2 5.2 -0.4 -1.0 -1.9 -1.0 -2.3
Exposure to tobacco smoke at home 1.0 1.1 2.1 -0.3 -1.4 -1.1 -0.9 -1.1
Breastfed as a baby 1.4 1.8 3.4 1.3 0.5 1.2 1.8 1.5
Tense / ‘highly strung’ 0.3 0.4 0.8 -0.5 -0.8 -0.4 -0.9 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 -0.8 -0.9 0.1 0.4 -1.0
Hair/balding pattern: Pattern 4 0.1 0.1 0.4 0.4 -0.4 -0.1 0.6 0.1
Birth weight of first child 0.2 0.3 0.5 0.5 0.3 -0.6 -0.7 -0.4
Peak expiratory flow (PEF) 0.8 1.8 4.7 0.7 -0.5 -1.6 -2.2 1.1
Pulse wave reflection index 0.2 0.2 0.5 -0.2 -0.4 -0.1 -0.7 -0.5
Ever highly irritable/argumentative for 2 days 1.5 1.7 5.8 2.4 -0.3 -1.2 -1.1 0.4
Loud music exposure frequency 0.6 0.7 1.8 -0.2 0.2 -1.3 -0.7 -1.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.3 1.2 -0.6 -0.3 -0.8 0.2
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 4.1 -0.8 -1.0 -2.0 -1.4 -1.3
Blood clot in the leg (DVT) 0.5 0.6 1.9 0.6 -0.7 -0.7 0.0 -1.4
Medication: Paracetamol 0.6 1.0 2.4 0.7 1.3 0.7 -0.2 1.5
Headache pain in last month 0.2 0.4 0.8 0.2 -0.8 -0.9 -0.7 -0.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.3 0.4 -0.4 0.0 0.6 1.1
Glaucoma (self-reported) 0.7 0.8 2.0 -0.8 0.2 -0.9 -1.4 -0.7
Gout (self-reported) 0.6 0.8 2.6 -0.5 -0.8 -0.5 -1.6 -0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.8 -1.3 0.3 0.4 -0.6 1.1
Medication: Amlodipine 0.5 0.8 2.0 -0.5 -0.5 -0.6 -1.4 -0.9
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.4 -0.1 0.7 -0.0 -0.6 -1.2
Birth weight 1.8 3.9 7.4 0.3 2.5 2.7 2.3 0.2
Chronic bronchitis/emphysema (mother) 4.7 5.5 8.9 -0.4 -2.7 -3.0 -2.5 -2.2
High blood pressure (siblings) 0.5 0.7 1.3 -1.2 -0.4 -0.7 -1.1 0.3
Forced vital capacity (FVC), Best measure 0.2 0.7 2.5 0.2 1.6 -0.3 -0.6 0.6
Body fat percentage 0.5 2.1 5.3 -0.6 -2.3 -0.2 -1.6 -1.5
Leg fat percentage (right) 0.7 2.6 6.2 -0.8 -2.5 0.2 -1.1 -2.1
Arm fat-free mass (right) 0.2 1.0 2.4 0.8 1.5 1.4 0.1 0.2
Exposure to tobacco smoke outside home 0.3 0.4 1.5 0.3 0.3 -0.0 -1.2 0.7
Comparative body size at age 10 0.9 2.4 4.7 -1.5 -1.3 -1.7 -0.7 -2.2
Number of full brothers 0.8 0.9 2.9 0.1 -0.1 -1.7 -1.3 0.3
Worry too long after embarrassment 0.2 0.3 0.9 -0.9 -0.8 0.1 -0.0 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.8 1.4 -0.6 0.1 0.3 0.6
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 0.8 0.2 0.4 0.4 0.7
Number of children fathered 0.4 0.4 0.9 -0.9 -0.1 -0.5 -0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.8 -0.4 0.9 0.3 0.8 0.6
Age at first live birth 2.5 4.4 13.6 3.7 1.5 1.7 1.2 1.4
Pulse wave peak to peak time 0.1 0.1 0.3 0.3 -0.3 0.3 0.5 0.3
Health satisfaction 1.0 1.3 3.7 1.4 -1.9 -0.7 -0.5 -0.2
Shortness of breath walking on level ground 0.7 0.9 2.1 0.7 -0.0 1.0 0.8 1.4
Qualifications: College or University degree 1.2 3.9 6.6 1.3 2.6 2.3 1.2 2.1
Eye problems/disorders: None of the above 0.8 0.9 2.2 0.7 0.7 1.1 0.2 1.5
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.3 -0.6 -1.3 -1.5 -1.5 -0.6
Emphysema/chronic bronchitis 2.6 3.0 5.0 -2.2 -0.6 -1.9 -0.9 -2.2
Medication for pain relief, constipation, heartburn 0.2 0.3 0.9 0.6 -0.3 0.5 1.0 0.2
Neck or shoulder pain in last month 1.2 1.7 2.3 -1.0 -1.2 -1.5 -1.5 -1.2
Medication: Blood pressure 0.1 0.2 0.8 0.2 0.4 0.5 0.0 -0.9
Angina (self-reported) 0.6 0.8 2.4 -0.6 -1.5 -0.0 -0.3 -1.0
Migraine (self-reported) 1.1 1.4 3.1 -1.5 1.8 1.3 -0.0 0.4
Medication: Ibuprofen 1.0 1.2 1.7 -1.1 0.1 -1.3 -1.2 -1.2
Medication: Allopurinol 0.4 0.5 1.1 -0.3 -1.0 -0.2 -0.8 0.8
Medication: Omeprazole 4.1 4.9 9.6 -2.2 -0.9 -3.1 -2.1 -2.2
Medication: Seretide 50 evohaler 0.1 0.1 0.1 0.4 -0.1 0.3 0.4 -0.0
Mean time to correctly identify matches 1.1 2.1 4.2 -0.1 1.8 2.0 1.4 1.2
Heart disease (mother) 0.4 0.5 1.5 0.1 0.8 0.1 -0.4 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 5.3 -2.1 -1.3 -2.3 -1.1 -0.2
Whole body fat mass 0.4 1.5 3.0 -0.6 -1.6 0.0 -1.7 -1.3
Leg fat mass (right) 0.5 1.8 3.3 -0.3 -1.8 0.2 -1.6 -1.8
Arm predicted mass (right) 0.3 1.7 3.2 1.3 1.8 1.8 0.2 0.6
Pulse rate, automated reading 0.3 1.1 3.4 1.9 1.3 -0.0 0.0 0.4
Alcohol intake frequency. 0.9 2.1 4.8 0.2 -2.2 -1.1 -1.9 0.7
Comparative height size at age 10 0.2 1.0 4.1 -0.9 2.0 0.2 0.2 0.5
Number of full sisters 1.3 1.5 3.6 0.6 1.9 0.0 1.9 0.3
Suffer from ‘nerves’ 2.5 3.9 7.2 -1.7 -2.7 -1.6 -1.5 -2.1
Overall health rating 3.4 7.3 12.7 -0.8 -3.6 -3.0 -2.6 -2.7
Chest pain or discomfort 0.2 0.2 0.7 0.6 0.4 0.1 -0.1 0.8
Had major operations 1.5 1.8 4.9 1.8 0.3 0.2 -0.7 2.2
Age at last live birth 2.5 3.7 8.1 2.9 1.1 2.0 1.1 1.9
Family relationship satisfaction 0.7 0.8 1.9 1.4 0.4 -0.4 -0.3 1.3
Leg pain on walking 0.1 0.1 0.6 0.2 0.0 -0.3 -0.8 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.2 0.1 1.1 1.0 -0.3 1.1
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.8 1.7 -1.4 -0.6 1.1 -0.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.3 0.3 0.3 1.2 0.1 0.4
Medication: Aspirin 0.1 0.1 0.5 -0.7 -0.0 -0.3 0.0 -0.2
Supplements: Vitamin C 0.1 0.2 0.4 -0.5 0.3 -0.2 -0.6 -0.1
Knee pain experienced in last month 0.3 0.5 1.5 -0.1 -0.5 0.9 -0.0 -1.2
Hypertension (Self-reported) 0.8 2.1 3.7 -0.9 -1.7 -1.6 -0.8 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.3 6.4 -2.5 -0.0 -0.8 -0.6 -2.1
Illnesses of father: Heart disease 1.1 1.6 3.6 0.9 -1.7 -1.9 -0.6 -0.3
Illnesses of siblings: Diabetes 0.6 0.8 1.2 -0.7 1.1 1.0 0.9 0.7
Smoking status: Previous 1.8 2.7 3.8 -1.7 -1.3 -1.9 -1.6 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.4 -0.4 1.2 1.0 -0.2 0.6
Whole body fat-free mass 0.2 1.0 2.9 0.8 1.7 1.1 -0.1 -0.4
Leg fat-free mass (right) 0.2 0.8 1.7 1.2 1.3 0.7 -0.5 -0.2
Arm fat percentage (left) 0.5 1.8 3.6 -0.4 -1.9 -0.3 -1.4 -1.7
Average weekly red wine intake 1.4 2.1 3.4 0.1 1.1 1.5 1.8 1.8
Handedness (chirality/laterality): Left-handed 1.2 1.5 2.7 -0.7 -0.9 -1.5 -1.6 -1.0
Mood swings 1.0 1.8 4.0 1.2 -2.0 -1.4 -1.2 0.4
Loneliness, isolation 0.5 0.6 1.6 1.3 -1.1 -0.5 0.4 0.2
Long-standing illness, disability or infirmity 0.2 0.4 1.0 0.4 0.7 1.0 -0.0 -0.3
Ever had bowel cancer screening 0.3 0.4 0.9 -0.8 -0.6 -0.1 0.0 -0.9
Diabetes diagnosed by doctor 0.4 0.6 1.6 -1.3 -0.2 0.1 -1.0 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.7 0.2 0.1 -0.3 -1.3 -0.5
Friendships satisfaction 0.3 0.4 1.3 1.1 -0.2 -0.7 -0.2 -0.0
Qualifications: nursing, teaching 1.6 2.5 4.6 1.6 1.3 1.5 1.2 2.2
Commuting to job workplace: Walk 0.3 0.3 0.7 0.8 0.7 0.6 -0.1 0.2
Eye problems/disorders: Cataract 0.1 0.2 0.2 -0.5 -0.2 -0.5 0.4 0.3
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.1 1.8 -1.4 -1.0 0.1 0.3
Medication for cholesterol 0.3 0.5 1.1 0.9 0.8 0.2 -0.3 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 0.5 -0.3 -0.8 -0.7 -0.3
Back pain experienced in last month 0.3 0.5 1.8 -0.4 -0.3 -0.4 0.6 -1.3
Mineral and other dietary supplements 0.3 0.4 0.6 -0.3 0.7 0.8 0.8 -0.5
Breast cancer (self-reported) 1.2 1.5 3.5 -0.6 -0.9 -1.9 -0.9 -1.3
Asthma (self-reported) 1.0 2.0 3.6 1.6 1.6 1.9 1.1 0.3
Osteoporosis (self-reported) 0.6 0.8 1.7 -0.5 -0.9 -1.3 -0.0 -1.1
Osteoarthritis (self-reported) 0.1 0.2 0.6 -0.3 -0.0 0.5 0.1 -0.8
Medication: Aspirin 0.2 0.2 0.6 -0.5 -0.2 -0.8 -0.4 -0.1
Medication: Gliclazide 0.8 0.9 2.3 -0.7 -0.3 -0.7 -1.5 -1.1
Illnesses of father: None of the above (group 1) 0.5 0.6 1.0 -1.0 0.5 -0.1 -1.0 -1.0
Smoking status: Current 0.4 0.6 1.3 0.5 -0.8 -1.1 -0.0 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.7 -0.5 0.7 -0.8 -1.9 -0.2
Whole body water mass 0.2 1.1 3.3 0.8 1.8 1.2 0.0 -0.3
Leg predicted mass (right) 0.2 0.8 1.8 1.2 1.4 0.7 -0.6 -0.2
Arm fat mass (left) 0.3 1.3 2.6 -0.4 -1.3 -0.1 -1.6 -1.4
Number of self-reported non-cancer illnesses 0.6 1.0 2.8 0.1 -1.3 -0.3 -1.7 -0.7
Average weekly champagne plus white wine intake 0.1 0.1 0.2 0.4 0.0 0.4 0.4 0.3
Miserableness 2.4 4.1 7.1 -0.1 -2.7 -2.6 -2.1 -1.6
Guilty feelings 0.9 1.3 2.4 -0.3 -1.5 -1.3 -0.4 -1.5
Wears glasses or contact lenses 1.3 1.5 2.2 -1.4 1.1 1.5 0.9 1.1
Ever taken oral contraceptive pill 0.7 0.8 1.8 0.9 -0.3 0.2 -1.0 1.3
Hearing aid user 0.5 0.6 1.7 -0.4 1.3 0.5 0.8 0.3
Mother’s age at death 0.2 0.2 0.6 0.4 0.1 0.6 0.8 0.1
Financial situation satisfaction 1.3 1.6 4.2 2.0 -0.8 -1.0 -1.4 0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.1 -0.2 0.1 -0.6 0.1
Commuting to job workplace: Public transport 0.9 1.0 2.2 -1.3 0.3 -0.5 -1.5 0.9
Eye problems/disorders: Glaucoma 0.4 0.4 1.2 -1.1 -0.3 0.1 -0.9 -0.1
Medication: Blood pressure 0.7 1.4 2.5 -1.4 -1.4 -1.6 -0.7 -0.5
Pain type(s) experienced in last month: Hip pain 1.0 1.2 2.8 -1.1 0.8 1.1 0.5 -1.7
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 0.9 -0.8 -0.8 -0.2 0.5
High cholesterol (Self-reported) 0.1 0.3 0.7 -0.5 -0.1 -0.8 -0.6 0.0
Medication: Bendroflumethiazide 0.9 1.3 2.2 1.2 1.0 1.2 1.5 0.8
Medication: Paracetamol 0.4 0.6 1.1 0.5 1.0 -0.1 -1.0 0.9
Medication: Lisinopril 1.0 1.3 2.3 1.5 0.4 1.1 1.4 0.9
Medication: Atorvastatin 0.9 1.1 3.9 -2.0 0.6 -0.2 -0.5 -1.0
Illnesses of father: High blood pressure 0.5 0.6 1.3 1.0 -1.1 0.5 0.3 0.6
Alcohol drinker status: Never 0.5 0.6 2.2 0.7 -1.5 -0.6 -0.3 -0.3
Ever smoked 0.2 0.3 0.8 -0.3 0.0 -0.8 -0.3 -0.9
Basal metabolic rate 0.1 0.7 1.8 0.7 1.3 0.9 -0.4 -0.6
Leg fat percentage (left) 0.7 2.6 6.3 -0.7 -2.5 0.1 -1.6 -1.9
Arm fat-free mass (left) 0.2 0.9 2.4 0.5 1.6 1.3 -0.2 -0.0
Number of operations (self-reported) 1.0 1.5 3.2 0.5 -1.8 -1.3 -1.2 1.0
Average weekly beer plus cider intake 0.2 0.3 0.7 0.8 -0.4 0.2 0.5 -0.8
Irritability 0.8 1.3 3.1 1.8 -0.6 -0.6 -1.4 0.7
Risk taking 0.2 0.2 0.8 0.4 0.9 -0.3 -0.2 -0.4
Ever had prostate specific antigen (PSA) test 0.9 1.0 3.7 -0.3 0.7 0.7 1.9 -0.6
Fractured/broken bones in last 5 years 0.5 0.7 1.8 0.5 -1.0 -1.3 -0.4 -0.3
Age started oral contraceptive pill 2.8 3.5 8.1 0.1 1.6 2.3 2.9 1.2
Diastolic blood pressure, automated reading 1.1 3.5 5.6 0.5 -2.4 -2.0 -2.3 -1.6
Ever depressed for a whole week 1.2 1.4 4.2 2.1 0.5 0.7 0.2 1.5
Unable to work because of sickness or disability 0.5 0.6 2.0 0.2 -0.5 -1.4 0.5 -0.7
Commuting to job workplace: Cycle 0.6 0.8 1.5 -0.5 1.0 1.2 0.1 1.1
Myopia 4.5 6.5 11.3 2.3 3.4 2.4 2.9 1.5
Vascular/heart problems diagnosed by doctor 1.0 2.7 4.9 1.0 2.0 1.6 1.1 2.2
Cholesterol lowering medication 1.4 2.1 4.7 -2.2 -1.3 -1.2 -0.5 -1.6
Medication: Omeprazole (e.g. Zanprol) 4.0 4.9 10.6 -1.6 -0.8 -3.3 -2.1 -2.5
Pain experienced in last month 0.1 0.2 0.6 -0.2 -0.2 -0.4 0.1 0.8
Supplements: Calcium 1.2 1.4 3.1 1.8 0.0 -1.5 0.4 -1.2
Basal cell carcinoma (self-reported) 0.4 0.5 0.9 0.6 -0.6 -1.0 0.3 -0.9
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 -0.9 -0.7 -0.7 -0.5 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.8 0.8 -1.0 -1.0 -0.1 -1.4
Heart disease (siblings) 1.5 1.8 3.6 -1.3 -1.4 -1.9 -1.0 -0.8
Alcohol drinker status: Previous 0.5 0.6 1.4 0.0 -0.2 1.1 1.2 0.3
Pack years of smoking 0.7 1.0 2.2 -0.5 -1.1 -1.5 -0.4 -1.1
Impedance of whole body 0.5 2.4 4.5 -2.1 -1.5 -1.7 -1.3 -0.5
Leg fat mass (left) 0.5 1.8 3.2 -0.2 -1.8 0.1 -1.7 -1.7
Arm predicted mass (left) 0.1 0.7 1.8 0.6 1.4 1.2 -0.2 -0.0