TWAS hub - RDM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0560	0.0250	6.4e-06	0.029	0.028	0.034	NA	0.035	1.1e-06	1.6e-06	1.5e-07	NA	7.4e-08
2	TCGA	Cervical Squamous Cell Carcinoma	0.0610	0.0330	6.4e-03	0.038	0.027	0.030	NA	0.030	5.5e-03	1.7e-02	1.3e-02	NA	1.3e-02
3	TCGA	Colon Adenocarcinoma	0.0810	0.0430	3.3e-03	0.018	0.029	0.011	NA	0.016	2.9e-02	8.2e-03	7.2e-02	NA	4.1e-02
4	TCGA	Glioblastoma Multiforme	0.2310	0.1000	1.7e-03	0.030	0.027	-0.003	NA	0.027	4.3e-02	5.0e-02	4.0e-01	NA	5.3e-02
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0637	0.0302	8.2e-05	0.005	0.014	0.019	NA	0.019	7.8e-02	9.6e-03	2.8e-03	NA	2.6e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0815	0.0388	5.5e-04	0.041	0.031	0.034	NA	0.037	1.8e-05	1.7e-04	1.0e-04	NA	4.9e-05
7	TCGA	Lung Adenocarcinoma	0.0610	0.0305	1.1e-03	0.006	0.025	0.022	NA	0.027	6.1e-02	5.3e-04	1.2e-03	NA	3.5e-04
8	TCGA	Lung Squamous Cell Carcinoma	0.0684	0.0360	7.7e-05	0.033	0.015	0.043	NA	0.038	9.9e-05	6.3e-03	1.1e-05	NA	3.8e-05
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.2190	0.0890	4.2e-06	0.081	0.053	0.094	NA	0.091	4.1e-06	1.8e-04	6.9e-07	NA	9.5e-07
10	TCGA	Pancreatic Adenocarcinoma	0.0710	0.0400	5.3e-03	0.020	0.016	0.004	NA	0.012	4.7e-02	6.9e-02	2.1e-01	NA	9.6e-02
11	TCGA	Rectum Adenocarcinoma	0.2070	0.0930	1.8e-03	0.190	0.115	0.108	NA	0.112	3.2e-05	1.2e-03	1.7e-03	NA	1.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Angina	2.9	3.8	5.7	1.6	2.3	2.4	1.5	2.0	1.4	1.6	2.1	2.1	2.1	2.1
Heart attack/myocardial infarction (self-reported)	2.9	3.7	7.5	1.2	2.7	2.2	1.3	1.8	1.3	2.1	2.1	1.8	2.2	1.9
Heart attack	2.8	3.6	7.6	1.0	2.8	2.0	1.2	1.7	1.2	2.0	2.0	1.9	2.3	1.9
Age at First Birth	2.7	3.9	10.2	0.4	-3.2	-2.2	-3.0	-1.0	0.7	-0.3	-1.6	-0.1	-3.1	-2.4
Pulse wave Arterial Stiffness index	2.7	3.2	4.9	2.1	1.1	1.9	1.4	2.2	1.8	1.4	1.8	2.2	1.4	1.9
Ever used hormone-replacement therapy (HRT)	2.6	3.3	5.3	2.3	1.6	2.1	1.4	1.7	1.9	1.6	1.3	2.1	1.6	2.0
Medication: Simvastatin	2.5	3.6	5.4	1.8	1.8	2.2	2.1	1.8	1.2	1.6	1.8	1.9	2.2	2.3
Osteoporosis (self-reported)	2.5	3.1	5.4	2.0	0.8	1.1	2.3	2.1	2.1	1.6	1.3	1.9	1.5	1.9
Pulse wave reflection index	2.4	2.9	6.3	2.5	0.4	1.7	0.8	2.2	2.5	1.2	1.1	2.4	0.6	1.5
Pulse wave peak to peak time	2.4	2.8	4.0	-1.9	-1.2	-1.7	-1.4	-2.0	-1.5	-1.3	-1.7	-2.0	-1.5	-1.8
Unable to work because of sickness or disability	2.4	3.1	4.6	1.9	1.7	2.1	2.1	1.7	0.8	1.2	2.1	1.0	2.0	2.1
Basal cell carcinoma (self-reported)	2.4	2.9	7.0	-0.5	-2.6	-2.1	-1.6	-1.0	-0.8	-2.0	-1.6	-1.5	-2.0	-1.7
Supplements: Glucosamine	2.3	3.1	7.0	1.7	1.8	1.6	2.6	1.2	0.8	1.6	1.3	1.1	2.4	2.1
Angina (self-reported)	2.2	2.8	4.5	1.4	2.1	2.1	1.4	1.7	1.1	1.3	1.7	1.8	1.9	1.8
Neuroticism (2016)	2.0	2.9	5.5	2.0	1.3	2.3	1.8	1.7	0.0	0.0	1.9	1.6	1.8	2.3
Impedance of leg (right)	2.0	9.7	14.5	-3.4	-2.3	-2.8	-2.1	-3.6	-3.8	-3.5	-3.2	-3.8	-2.2	-2.9
Impedance of leg (left)	2.0	9.9	13.5	-3.4	-2.7	-3.0	-2.5	-3.5	-3.4	-3.4	-3.2	-3.7	-2.6	-3.0
Blood Platelet Count	1.9	21.6	30.4	-5.5	-3.2	-5.2	-3.9	-5.5	-4.6	-4.4	-4.9	-4.5	-3.6	-5.2
Diabetes (mother)	1.9	2.4	5.6	1.9	0.2	1.2	1.3	2.3	1.8	1.4	2.4	1.2	0.5	1.4
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.7	-1.6	-0.7	-1.1	-1.5	-1.9	-1.9	-1.6	-1.4	-1.7	-1.0	-1.5
Medication: Atenolol	1.8	2.3	3.9	1.5	1.7	1.7	0.7	1.5	1.5	1.5	1.5	2.0	1.4	1.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.0	2.2	0.8	2.0	1.8	1.5	1.7	1.9	1.6	1.9	1.1	1.8
Depressed Affect (Nagel 2018)	1.7	3.5	11.2	0.1	3.4	2.2	2.1	0.9	-0.6	0.4	1.6	0.2	3.1	2.1
Body mass index (BMI)	1.7	7.4	13.0	2.4	3.0	2.5	1.3	2.9	3.1	3.3	2.6	3.6	2.3	2.3
Ever highly irritable/argumentative for 2 days	1.7	2.0	4.6	-1.6	-0.7	-1.3	-1.0	-1.4	-1.9	-2.1	-1.2	-1.5	-0.6	-1.4
Mean time to correctly identify matches	1.7	3.2	5.5	1.6	1.7	1.6	2.1	1.5	1.5	1.8	1.4	2.3	2.0	1.9
Smoking status: Previous	1.7	2.5	4.8	1.1	1.6	2.2	1.4	1.3	0.9	1.9	1.8	0.8	1.6	2.1
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	4.9	2.2	1.2	2.0	1.5	1.5	1.4	1.5	1.3	1.9	1.5	1.9
Cholesterol lowering medication	1.7	2.5	5.6	1.4	0.9	1.3	2.4	1.2	1.4	1.7	0.8	1.6	1.8	2.1
Pain experienced in last month	1.7	2.8	14.0	0.7	-3.7	-1.4	-1.0	-0.6	0.4	-1.0	-1.3	-1.1	-2.7	-1.1
Worrier / anxious feelings	1.6	3.0	10.1	-3.2	2.2	-0.7	0.4	-1.7	-2.6	-1.6	-1.1	-1.1	1.7	-0.6
Medication: Omeprazole	1.6	1.9	5.3	0.6	1.3	1.3	2.3	0.8	-0.3	0.5	1.1	-0.1	2.3	2.1
Average weekly spirits intake	1.5	1.9	3.0	-1.1	-1.4	-1.5	-1.2	-1.5	-1.0	-1.6	-1.7	-1.1	-1.4	-1.5
Alcohol usually taken with meals	1.5	2.5	6.3	-0.4	-2.4	-1.9	-2.2	-0.4	-0.0	-1.0	-0.7	-1.4	-2.5	-1.8
Had menopause	1.5	1.9	4.9	0.3	2.2	2.1	1.4	0.5	-0.2	0.8	1.2	0.7	2.0	1.7
Ever had bowel cancer screening	1.5	1.7	2.7	1.6	0.4	1.6	1.3	1.2	1.1	1.5	1.5	1.2	0.9	1.6
Back pain experienced in last month	1.5	2.2	9.1	0.3	3.0	1.3	0.9	1.1	0.3	0.8	1.0	1.2	2.4	1.3
Bipolar Disorder (2011)	1.4	1.3	4.8	0.0	-1.1	-1.4	-1.4	0.0	0.0	0.0	0.0	-2.2	-1.4	-1.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	3.0	1.2	1.3	1.7	1.5	1.1	0.3	0.7	1.5	0.7	1.6	1.7
Forced vital capacity (FVC)	1.4	5.4	7.2	-2.4	-1.9	-2.3	-2.5	-2.3	-2.0	-2.5	-2.1	-2.5	-2.4	-2.7
Hip circumference	1.4	5.9	11.2	2.7	1.3	1.8	0.6	2.9	3.4	3.3	2.8	3.3	0.8	1.5
Handedness (chirality/laterality): Left-handed	1.4	1.6	3.7	-1.5	-0.3	-0.8	-0.8	-1.4	-1.8	-1.7	-1.1	-1.9	-0.5	-1.1
Financial situation satisfaction	1.4	1.7	3.1	-1.6	-0.6	-1.4	-1.8	-0.9	-1.2	-1.5	-0.8	-1.7	-1.1	-1.4
Waist Hip Ratio (WHR)	1.3	6.0	13.0	-2.5	-1.7	-2.2	-1.8	-2.4	-3.0	-3.4	-2.0	-3.6	-1.5	-1.9
Chronotype (morning person)	1.3	2.9	10.9	2.2	-1.7	0.5	-0.9	1.2	3.3	1.9	0.1	1.8	-2.0	0.0
Ever had hysterectomy (womb removed)	1.3	1.4	3.2	0.8	1.1	0.9	1.6	1.0	0.6	1.1	0.7	1.5	1.8	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	4.2	-1.7	1.7	-0.5	-0.4	-0.9	-2.0	-2.0	-0.7	-1.1	1.1	-0.7
Worry too long after embarrassment	1.3	2.3	4.7	-1.9	0.2	-1.4	0.2	-1.9	-2.2	-1.8	-1.8	-1.9	0.3	-0.9
Family relationship satisfaction	1.3	1.6	3.4	-0.9	-1.4	-1.7	-0.1	-1.0	-1.6	-1.8	-1.1	-1.8	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.6	-0.6	-1.8	-2.2	-2.1	-1.0	-0.5	-1.5	-1.3	-0.9	-2.2	-2.4
Supplements: Calcium	1.3	1.5	3.6	1.4	1.1	1.4	0.7	1.6	1.2	0.7	1.9	0.9	0.7	1.0
Impedance of whole body	1.3	6.6	10.8	-2.9	-1.7	-2.0	-1.7	-3.1	-3.3	-3.1	-2.6	-3.1	-1.7	-2.3
Average weekly red wine intake	1.2	1.8	5.8	2.4	-0.8	0.9	1.0	1.5	1.7	1.0	1.0	1.5	0.2	1.4
Miserableness	1.2	2.0	7.0	-0.1	2.6	1.8	1.4	0.5	-1.0	-0.4	1.1	0.1	2.4	1.4
Alcohol drinker status: Never	1.2	1.5	3.7	1.1	1.2	1.9	0.8	1.4	0.7	0.7	1.6	0.8	0.9	1.5
Schizophrenia vs Biploar Disorder	1.1	1.5	3.0	0.0	-0.7	-1.4	-1.2	-1.5	-1.3	-1.3	-1.4	-0.7	-1.1	-1.7
Qualifications: CSEs or equivalent	1.1	1.5	3.8	1.8	0.7	1.9	1.0	0.9	1.3	0.8	0.4	1.2	0.7	1.4
Arm fat mass (right)	1.1	4.7	8.5	1.9	2.4	2.0	0.5	2.3	2.7	2.8	2.1	2.9	1.5	1.6
Number of full sisters	1.1	1.3	3.1	-1.2	-0.6	-0.7	-1.8	-1.5	-0.8	-1.0	-1.2	-0.8	-1.2	-1.3
Overall health rating	1.1	2.5	5.7	1.1	2.1	1.8	1.5	1.3	0.4	0.7	1.5	1.4	2.4	1.9
Had major operations	1.1	1.3	2.5	-1.0	-1.4	-1.1	-0.7	-1.4	-1.6	-1.1	-1.1	-1.3	-0.7	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.9	-0.7	-1.1	-1.4	-1.1	-1.0	-0.9	-1.3	-1.2	-1.0	-1.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	5.6	-1.4	0.8	-0.3	-0.1	-0.7	-2.4	-1.5	0.6	-1.6	0.8	-0.2
Arm fat percentage (left)	1.1	4.3	9.2	1.4	3.0	2.1	0.7	1.8	2.1	2.5	1.8	2.7	2.0	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.0	-0.4	-1.6	-1.0	-1.7	-0.1	-0.2	-1.1	-0.4	-0.9	-1.7	-1.3
Smoking status: Current	1.1	1.8	4.5	-1.6	-0.5	-1.4	-0.5	-1.5	-2.1	-1.9	-1.1	-1.6	-0.1	-1.0
Arm fat mass (left)	1.1	4.4	8.1	1.8	2.2	1.9	0.4	2.3	2.7	2.8	2.1	2.9	1.3	1.5
Guilty feelings	1.1	1.6	4.6	-1.3	-0.4	-1.3	-0.4	-1.2	-2.0	-2.2	-1.1	-1.3	-0.0	-0.9
Breast Cancer	1.0	2.3	4.2	1.0	2.0	1.7	0.6	1.8	1.4	1.7	2.0	1.2	1.2	1.3
Primary Biliary Cirrhosis	1.0	1.5	3.6	0.0	1.3	1.7	1.6	0.0	0.0	0.0	1.9	0.0	1.3	1.9
Diabetes (father)	1.0	1.2	2.8	-1.0	-0.8	-0.6	-0.9	-1.1	-1.3	-1.7	-0.6	-1.4	-1.0	-1.2
Current tobacco smoking	1.0	1.7	3.6	-1.4	-0.7	-1.4	-0.8	-1.4	-1.9	-1.8	-1.1	-1.4	-0.4	-1.2
Past tobacco smoking	1.0	1.8	3.4	-0.7	-1.5	-1.8	-1.5	-1.1	-0.3	-1.2	-1.6	-0.3	-1.6	-1.8
Impedance of arm (right)	1.0	4.7	10.1	-2.5	-0.7	-1.5	-1.1	-2.7	-3.2	-2.8	-2.2	-2.8	-0.8	-1.7
Number of live births	1.0	1.4	3.2	-1.4	-0.1	-0.8	-1.0	-1.2	-1.6	-1.8	-0.9	-1.5	-0.6	-1.2
Tense / ‘highly strung’	1.0	1.6	3.5	-1.5	0.6	-0.9	-0.4	-1.6	-1.9	-1.8	-1.5	-1.3	0.5	-0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.6	-0.8	-1.4	-0.8	-1.8	-0.7	-0.3	-0.5	-0.1	-1.3	-1.9	-1.3
Whole body fat mass	1.0	4.3	8.3	1.8	1.9	1.8	-0.0	2.3	2.8	2.8	2.1	2.9	0.9	1.3
Suffer from ‘nerves’	1.0	1.6	5.5	-0.3	1.8	1.2	1.7	0.1	-1.1	-0.3	0.6	-0.5	2.3	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	7.8	-0.6	2.8	1.2	1.9	0.2	-0.6	0.9	1.0	0.8	2.4	1.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.7	1.4	0.4	0.7	-0.2	1.4	1.8	1.1	0.7	2.2	0.1	0.4
Leg fat mass (left)	1.0	4.1	8.5	1.7	1.9	1.7	-0.1	2.3	2.7	2.7	2.1	2.9	1.0	1.2
Crohns Disease (2017)	0.9	2.0	3.6	-1.4	-0.4	-1.2	-1.2	-1.9	-1.4	-1.5	-1.9	-1.4	-0.8	-1.5
Pack years adult smoking proportion	0.9	1.3	3.5	1.4	0.4	0.9	0.0	1.7	1.4	1.0	1.9	1.2	0.3	0.8
Trunk fat percentage	0.9	3.5	6.6	1.5	2.3	2.1	0.1	1.8	2.2	2.4	1.8	2.6	1.2	1.4
Fed-up feelings	0.9	1.6	5.9	-0.2	2.4	1.2	1.5	0.0	-1.1	-0.4	0.6	0.1	2.2	0.9
Trunk fat mass	0.9	3.7	7.3	1.7	1.8	1.8	-0.2	2.1	2.6	2.6	1.9	2.7	0.8	1.2
Weight	0.9	4.3	9.7	2.2	1.0	1.4	-0.2	2.6	3.1	2.8	2.3	3.0	0.3	1.1
Arm fat percentage (right)	0.9	3.6	8.7	1.2	2.9	1.9	0.6	1.6	1.8	2.2	1.6	2.4	1.9	1.5
Medication: Paracetamol	0.9	1.5	2.7	-1.4	0.2	-0.9	-1.6	-1.4	-1.1	-1.4	-1.5	-0.9	-0.7	-1.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.9	1.2	0.7	1.3	2.2	0.7	0.8	0.6	0.0	1.3	1.7	1.9
Body fat percentage	0.9	3.6	6.6	1.4	2.4	2.0	0.3	1.8	2.2	2.5	1.8	2.6	1.4	1.4
Number of full brothers	0.9	1.1	1.7	-0.7	-1.3	-1.2	-1.3	-0.8	-0.9	-1.3	-0.7	-0.9	-1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.6	-1.6	0.1	-0.8	-0.4	-1.2	-1.2	-1.1	-1.3	-1.6	-0.1	-0.6
Leg fat mass (right)	0.9	3.4	6.6	1.5	1.8	1.5	-0.0	2.1	2.5	2.5	1.9	2.6	0.9	1.1
Mood swings	0.9	1.7	4.7	0.6	2.2	2.0	1.2	0.9	-0.3	-0.2	1.2	0.5	1.9	1.4
Mineral and other dietary supplements	0.9	1.1	2.6	-1.6	-0.6	-1.5	-0.9	-0.9	-0.9	-0.9	-1.1	-0.8	-0.8	-1.3
Tinnitus: Yes, now most or all of the time	0.9	1.0	3.6	-1.0	1.8	0.4	1.1	-0.5	-1.0	-0.1	-0.4	0.6	1.9	0.6
Heart disease (siblings)	0.9	1.1	2.6	0.6	0.9	1.1	1.4	0.8	0.3	0.5	0.4	0.9	1.6	1.6
Pack years of smoking	0.9	1.4	3.7	1.5	0.2	0.9	-0.0	1.8	1.5	1.0	1.9	1.2	0.2	0.9
Worry (Nagel 2018)	0.8	1.8	4.8	-1.9	1.4	-0.4	0.4	-1.2	-2.2	-1.6	-0.6	-1.6	1.3	-0.1
Ovarian Cancer	0.8	1.1	4.8	-1.5	2.2	-0.1	0.8	-0.4	-1.0	-0.1	0.0	-0.5	1.8	0.2
Prostate Cancer	0.8	1.1	3.0	0.9	0.9	0.7	1.1	0.9	1.1	1.2	0.5	1.7	1.0	0.9
Pulse rate	0.8	1.4	3.4	-1.8	-0.3	-0.5	-1.0	-1.3	-1.6	-1.1	-0.5	-1.8	-0.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.6	0.7	-0.9	-0.3	-2.1	0.1	0.7	-0.4	-0.4	0.6	-1.6	-1.2
Medication: Lansoprazole	0.8	0.9	4.2	-0.1	2.0	0.5	0.9	0.4	-0.3	-0.0	0.4	0.5	1.9	0.7
Lung cancer (father)	0.8	0.9	3.6	-0.0	1.9	1.1	0.4	0.5	-0.1	0.4	1.0	1.0	1.5	0.7
Exposure to tobacco smoke at home	0.8	0.9	2.8	-1.7	0.1	-0.0	-0.8	-1.4	-1.1	-0.5	-1.1	-0.9	-0.4	-0.5
Leg fat percentage (right)	0.8	2.7	6.2	0.8	2.5	1.6	0.5	1.5	1.5	2.0	1.5	2.1	1.7	1.4
Comparative body size at age 10	0.8	2.3	10.6	-0.8	3.3	0.8	1.3	0.2	-1.2	0.1	1.3	-0.4	2.7	0.8
Chest pain or discomfort	0.8	1.1	3.1	-0.0	1.6	1.0	1.2	0.8	0.0	0.6	1.2	0.9	1.8	1.1
Diabetes diagnosed by doctor	0.8	1.4	2.8	0.1	1.7	1.0	1.3	0.9	0.3	1.1	1.4	1.1	1.6	1.2
Number of self-reported non-cancer illnesses	0.8	1.3	3.6	0.4	1.8	1.2	1.2	0.8	0.0	0.3	1.2	0.9	1.9	1.3
Leg fat percentage (left)	0.8	2.9	5.4	0.9	2.3	1.5	0.3	1.7	1.8	2.2	1.6	2.3	1.5	1.3
Fractured/broken bones in last 5 years	0.8	1.1	2.7	0.2	1.2	0.3	1.5	1.1	0.7	0.8	0.9	0.8	1.6	1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.6	-0.7	1.0	0.3	1.1	-0.3	-1.6	-0.9	0.1	-1.1	1.6	0.8
Neuroticism (Nagel 2018)	0.7	1.8	4.8	-1.2	2.2	0.4	1.1	-0.5	-1.8	-1.4	-0.2	-1.1	2.1	0.7
Major Depression (MDD)	0.7	0.9	4.0	0.0	2.0	0.7	0.6	0.3	-0.6	-0.1	0.5	0.3	1.8	0.8
Triglycerides	0.7	1.1	2.7	0.0	1.2	1.5	1.3	0.0	0.0	0.0	1.0	1.0	1.3	1.7
BMI	0.7	4.1	7.3	1.6	2.4	1.9	0.8	2.2	2.3	2.3	2.0	2.7	1.7	1.7
Severe depression (siblings)	0.7	0.8	1.7	-0.5	-0.9	-1.2	-0.5	-1.0	-0.8	-1.0	-1.1	-1.3	-0.4	-0.6
Leg fat-free mass (left)	0.7	3.5	9.6	2.4	0.1	1.0	-0.4	2.4	3.1	2.4	1.9	2.6	-0.4	0.7
Sitting height	0.7	5.1	15.4	-0.1	-3.9	-2.4	-3.1	-0.3	0.6	-1.1	-1.0	-0.7	-3.9	-2.6
Leg predicted mass (left)	0.7	3.6	9.7	2.4	0.1	1.1	-0.4	2.5	3.1	2.4	2.0	2.6	-0.4	0.8
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.4	1.4	0.6	1.1	1.4	1.5	1.3	1.3	1.4	1.0	0.9	1.3
Mouth/teeth dental problems: Dentures	0.7	1.2	3.3	-0.1	1.8	1.2	1.1	0.7	-0.3	0.6	1.2	0.8	1.7	1.2
Illnesses of mother	0.7	0.9	1.7	-0.5	-1.3	-0.8	-1.3	-0.5	-0.8	-1.1	-0.3	-1.0	-1.2	-0.9
Blood clot in the leg (DVT)	0.7	0.9	3.3	1.1	0.3	0.5	-0.5	1.1	1.6	0.9	0.5	1.8	-0.2	0.1
Medication: Amlodipine	0.7	0.9	1.9	-0.6	-1.4	-1.3	-0.8	-0.8	-0.4	-0.9	-0.9	-0.7	-1.1	-1.2
Birth weight	0.7	1.5	3.0	1.7	0.8	1.1	1.5	1.2	0.9	1.2	1.5	1.1	1.1	1.3
Exposure to tobacco smoke outside home	0.7	0.9	2.6	0.4	1.6	1.4	-0.1	0.9	0.4	0.6	1.4	0.9	0.7	0.6
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.3	-1.0	-0.6	-1.3	-0.9	-0.5	-0.8	-0.8	-0.9	-1.3	-1.0
Pulse rate, automated reading	0.7	2.3	5.3	-1.8	-1.4	-1.3	-0.7	-1.2	-2.3	-1.8	-0.2	-2.3	-1.0	-1.2
Supplements: Vitamin C	0.7	0.8	1.8	0.9	-0.7	0.5	-0.9	0.6	1.3	0.7	0.5	1.3	-1.3	-0.5
Knee pain experienced in last month	0.7	1.1	2.5	0.7	1.6	1.5	1.0	0.6	-0.2	0.4	1.1	0.3	1.6	1.4
Leg fat-free mass (right)	0.7	3.8	10.2	2.4	-0.0	1.0	-0.5	2.6	3.2	2.4	2.1	2.6	-0.5	0.7
Osteoarthritis (self-reported)	0.7	0.9	3.0	0.3	1.7	1.1	0.9	-0.0	-0.7	-0.2	0.4	0.3	1.7	1.1
Leg predicted mass (right)	0.7	3.7	10.0	2.4	-0.0	1.0	-0.5	2.5	3.2	2.4	2.1	2.5	-0.5	0.7
Average weekly champagne plus white wine intake	0.7	0.9	2.1	-1.0	-1.3	-1.0	-1.1	-0.6	-0.5	-0.5	-0.4	-0.8	-1.4	-1.2
Depression (Nagel 2018)	0.6	1.0	3.2	-0.9	1.8	0.7	0.2	0.2	-1.1	-1.3	0.4	-0.9	1.4	0.6
Alzheimer’s Disease (in father)	0.6	0.7	1.8	-1.3	0.3	-1.2	-1.3	-0.2	-0.5	-0.6	-0.3	-0.4	-0.3	-1.2
Hypothyroidism (self reported)	0.6	1.4	4.5	0.8	0.7	0.9	2.1	0.1	0.5	0.8	-0.5	1.5	1.8	1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.0	0.6	1.1	0.8	1.0	1.1	1.0	1.4	1.3	0.9	1.0	1.0
Neuroticism	0.6	1.5	5.9	-0.6	2.4	1.0	1.0	-0.2	-1.4	-0.8	0.4	-0.4	2.0	0.8
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.5	-0.4	1.4	0.4	0.7	-0.2	-1.4	-1.5	-0.0	-0.5	1.6	0.5
Relative age of first facial hair	0.6	1.3	6.4	0.4	-2.5	-1.3	-0.5	-0.6	0.5	-0.2	-1.4	-0.5	-1.5	-0.5
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-1.0	0.1	-0.2	-1.3	-1.1	-0.8	-0.9	-1.2	-0.6	-0.5	-0.8
Nervous feelings	0.6	1.1	2.5	-1.6	0.6	-0.5	0.1	-1.3	-1.6	-1.2	-1.1	-1.2	0.6	-0.2
Hair/balding pattern: Pattern 2	0.6	0.7	1.5	0.3	1.0	1.1	0.6	0.8	1.1	1.2	1.1	0.5	0.3	0.7
Neuroticism score	0.6	1.3	4.0	-1.2	2.0	0.5	0.6	-0.7	-1.8	-1.3	-0.2	-0.8	1.6	0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	3.2	-1.4	-1.1	-1.6	-1.8	-1.2	-1.0	-1.6	-1.2	-1.5	-1.6	-1.8
Impedance of arm (left)	0.6	2.6	5.6	-1.8	-0.6	-0.9	-0.8	-2.2	-2.4	-2.0	-1.7	-2.0	-0.8	-1.3
Standing height	0.6	6.2	19.5	-0.2	-4.3	-2.5	-3.6	-0.6	0.3	-1.1	-0.9	-1.1	-4.4	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.1	0.3	1.6	0.9	0.8	0.6	-0.3	-0.4	0.6	0.4	1.8	1.1
Headache pain in last month	0.6	0.9	4.5	-0.6	2.1	1.1	0.3	0.1	-0.1	1.1	0.7	0.5	1.3	0.7
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	-1.0	1.3	0.7	0.3	-0.9	-1.2	-0.2	-0.3	-1.2	0.9	0.4
Arm fat-free mass (right)	0.6	3.2	9.8	2.2	-0.8	0.4	-0.7	2.3	3.1	2.3	1.7	2.3	-1.0	0.4
Shortness of breath walking on level ground	0.6	0.7	2.4	0.2	-1.5	-0.7	-1.0	-0.4	0.6	0.1	-0.7	-0.7	-1.5	-0.6
Eye problems/disorders: None of the above	0.6	0.6	1.8	1.1	0.1	0.4	0.5	1.0	1.3	1.1	0.3	1.0	0.2	0.5
Migraine (self-reported)	0.6	0.7	2.3	0.2	0.8	0.6	1.5	0.4	-0.4	0.1	0.6	0.3	1.5	1.2
Medication: Ibuprofen	0.6	0.7	3.6	0.5	-0.5	-0.2	-1.9	-0.1	0.5	-0.3	-0.4	0.7	-1.1	-1.0
Arm predicted mass (right)	0.6	3.3	9.9	2.2	-0.9	0.3	-0.7	2.3	3.1	2.3	1.7	2.2	-1.1	0.3
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	-1.4	0.6	-0.5	-0.7	-1.0	-0.7	-0.7	-1.1	-0.7	-0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.7	3.8	-1.0	2.0	0.6	-0.0	-0.3	-1.1	-0.2	0.6	-0.1	1.1	0.1
Medication: Paracetamol	0.6	0.9	2.5	-0.9	-0.0	-0.6	-1.6	-1.0	-0.7	-1.0	-1.0	-0.6	-0.9	-1.3
Average weekly beer plus cider intake	0.6	0.9	2.2	0.3	1.4	0.4	1.2	0.9	0.4	0.6	0.8	1.3	1.5	0.8
Arm predicted mass (left)	0.6	3.2	9.5	2.2	-0.7	0.5	-0.7	2.3	3.1	2.2	1.6	2.3	-0.9	0.4
Alzheimer’s Disease (in mother)	0.5	0.6	2.1	-1.1	1.5	-0.2	-0.4	-1.1	-0.4	0.7	-0.9	0.5	0.6	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.4	-1.5	1.4	-0.6	-0.8	-1.0	-0.7	0.3	-0.6	0.1	0.5	-0.8
Reaction Time	0.5	1.0	2.0	0.6	0.9	0.3	1.4	0.9	0.9	1.1	0.7	1.4	1.4	0.9
Blood Red Count	0.5	4.7	6.4	2.2	1.6	2.5	1.8	2.4	2.2	2.3	2.3	2.4	1.5	2.4
Sensitivity / hurt feelings	0.5	0.9	2.5	-0.6	1.2	0.2	0.9	-0.5	-1.6	-1.4	-0.2	-0.6	1.4	0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	1.4	0.1	0.8	0.8	0.7	0.9	0.3	0.0	1.0	0.7	1.1
Supplements: Zinc	0.5	0.5	2.0	0.3	-1.1	0.2	-1.0	0.3	0.3	-0.3	0.4	-0.5	-1.4	-0.5
Stomach or abdominal pain in last month	0.5	0.6	2.5	-0.1	1.3	0.2	0.9	0.5	-0.4	-0.0	0.6	0.9	1.6	0.5
Diabetes (self-reported)	0.5	0.8	1.3	0.4	1.0	0.9	0.9	0.8	0.4	0.7	0.9	1.1	1.1	0.9
Medication: Ramipril	0.5	0.6	1.7	0.8	0.4	0.5	0.7	0.3	1.0	1.3	-0.1	1.2	0.6	0.7
Fluid intelligence score	0.5	1.0	1.9	1.4	-0.5	0.6	-0.3	1.2	1.4	0.9	1.1	1.4	-0.7	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.7	0.3	1.6	0.9	1.0	0.7	-0.1	0.2	1.2	0.3	1.5	0.9
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	-0.1	-1.2	-0.0	-0.4	-0.8	-1.3	-1.2	-0.2	-1.4	-0.9	-0.5
Happiness	0.5	0.7	2.2	-0.7	-0.6	-0.3	-0.2	-0.4	-1.3	-1.5	-0.1	-1.5	-0.4	-0.3
Length of working week for main job	0.5	0.6	1.8	-0.0	-1.3	-0.5	-1.2	0.2	0.5	0.2	0.5	-0.1	-1.3	-0.6
Neck or shoulder pain in last month	0.5	0.6	2.0	-1.3	1.4	-0.4	-0.3	-0.8	-0.5	-0.1	-1.1	0.2	0.9	-0.1
Leg pain on walking	0.5	0.6	2.3	0.1	-1.3	0.3	-1.2	-0.6	-0.1	-0.4	-0.8	-0.1	-1.5	-0.6
Whole body fat-free mass	0.5	2.8	8.4	2.1	-0.9	0.3	-0.7	2.1	2.9	2.0	1.6	2.1	-1.0	0.3
Qualifications: nursing, teaching	0.5	0.8	2.5	-1.0	-0.1	-0.9	-0.7	-1.2	-0.6	-0.6	-1.6	-1.0	-0.3	-0.7
Medication: Gliclazide	0.5	0.5	2.3	-0.8	1.5	0.4	0.1	-0.5	-1.0	-0.1	0.5	-0.4	1.0	0.1
Whole body water mass	0.5	2.9	8.8	2.2	-0.8	0.4	-0.7	2.2	3.0	2.0	1.6	2.1	-0.9	0.4
Wears glasses or contact lenses	0.5	0.6	2.0	0.1	1.4	0.9	0.5	0.2	0.6	1.2	0.1	0.6	0.9	0.8
Medication: Lisinopril	0.5	0.6	1.4	0.9	-0.2	0.8	0.3	0.7	0.6	1.2	1.2	0.9	0.0	0.6
Basal metabolic rate	0.5	2.9	8.7	2.1	-0.5	0.5	-0.8	2.2	3.0	2.1	1.6	2.2	-0.8	0.4
Arm fat-free mass (left)	0.5	2.6	8.1	1.9	-0.6	0.3	-0.9	2.0	2.8	2.0	1.5	2.0	-0.9	0.2
Irritable Bowel Disease (IBD)	0.4	0.9	2.2	-1.4	0.4	-1.0	-0.4	-1.4	-0.9	-0.7	-1.5	-0.7	-0.1	-1.0
Coronary Artery Disease (CAD)	0.4	0.5	1.6	0.0	-1.1	-1.1	-0.2	0.0	0.0	0.0	0.0	-1.3	-0.7	-0.8
Schizophrenia (2014)	0.4	0.9	1.9	0.0	-0.6	-1.2	-1.1	-1.2	-0.8	-0.9	-0.9	-0.7	-0.9	-1.4
Height	0.4	8.5	26.8	-0.4	-4.6	-2.6	-4.4	-1.2	0.5	-1.2	-2.0	-1.3	-5.2	-3.3
Smoking Status	0.4	1.0	2.8	-0.5	1.4	0.8	1.1	-0.1	-1.1	-0.2	0.7	-0.8	1.7	1.1
Allergy or Eczema	0.4	1.0	1.9	-0.5	-1.4	-0.8	-0.8	-0.8	-0.7	-1.4	-0.9	-1.2	-1.2	-0.9
Lung FEV1/FVC ratio	0.4	1.9	4.2	1.7	1.2	0.4	0.9	2.0	1.9	1.2	1.6	1.4	1.2	1.1
Taking other prescription medications	0.4	0.6	1.6	-0.9	0.9	0.3	-0.1	-0.5	-1.2	-1.3	-0.6	-0.8	0.9	0.3
Multivitamins +/- minerals	0.4	0.6	2.5	0.1	-0.5	0.3	-0.6	-0.2	-1.0	-1.3	0.3	-1.6	-0.5	-0.2
Waist circumference	0.4	1.5	2.8	0.9	1.3	1.0	-0.3	1.4	1.5	1.6	1.7	1.4	0.6	0.7
Number of incorrect matches in round	0.4	0.7	2.8	0.2	0.8	0.1	1.7	0.4	-0.6	-0.3	0.5	0.4	1.6	0.7
Pain all over the body in last month	0.4	0.5	1.4	-0.7	1.2	-0.1	0.4	-0.4	-1.1	-0.7	-0.3	-0.3	1.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.2	1.2	0.7	0.8	0.6	-0.2	0.3	1.0	0.6	1.1	0.6
Asthma	0.4	0.8	1.9	0.7	1.4	0.9	0.6	1.0	0.7	0.7	0.7	1.1	1.1	0.8
Depression (self-reported)	0.4	0.5	1.3	-0.9	1.1	-0.4	-0.5	-0.3	-0.8	-0.8	-0.2	-1.1	0.5	-0.3
Peak expiratory flow (PEF)	0.4	0.8	2.3	-1.5	0.5	-0.6	-1.0	-0.9	-1.0	-0.9	-0.5	-1.2	-0.3	-0.9
Loud music exposure frequency	0.4	0.5	1.1	-0.7	-0.2	-0.5	-0.8	-0.6	-0.6	-1.1	-0.8	-1.1	-0.4	-0.5
Forced vital capacity (FVC), Best measure	0.4	1.5	2.3	-1.5	-0.9	-1.5	-0.8	-1.4	-1.2	-1.3	-1.3	-1.1	-1.0	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	0.5	0.7	0.6	0.7	1.0	-0.1	-0.2	1.3	0.0	1.0	0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	-0.5	-0.8	-1.0	0.0	-0.6	-0.4	-0.9	-0.9	-0.8	-0.2	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	1.1	-0.7	0.3	1.1	0.8	1.1	1.0	0.5	0.7	0.1	0.9
Illnesses of father: Heart disease	0.4	0.5	1.7	0.5	0.2	0.7	0.4	0.8	0.8	0.8	0.6	1.3	0.4	0.7
Commuting to job workplace: Walk	0.4	0.4	1.8	-0.5	0.1	0.2	-0.5	-0.9	-1.4	-0.7	-0.0	-0.9	-0.2	-0.5
Asthma (self-reported)	0.4	0.9	2.2	0.6	1.5	1.1	0.6	0.8	0.6	0.7	0.8	1.0	1.2	0.9
Medication: Bendroflumethiazide	0.4	0.6	1.6	0.8	0.2	0.5	0.1	0.7	1.1	1.2	0.6	1.3	-0.1	0.2
Medication: Atorvastatin	0.4	0.5	1.9	-0.5	1.4	-0.1	0.8	0.1	-0.5	-0.1	-0.0	0.1	1.4	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.3	-1.0	-0.4	-0.2	-0.5	-0.7	-1.0	-0.3	-1.1	-0.7	-0.5
Ever depressed for a whole week	0.4	0.5	1.1	-0.8	0.6	-0.1	0.8	0.1	-1.0	-0.9	0.2	-1.1	1.1	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.8	0.8	-1.3	-0.3	-0.9	0.4	0.8	0.2	0.2	0.8	-1.4	-0.7
HbA1C	0.3	0.4	1.8	-0.5	0.2	-0.6	-1.3	0.8	-0.3	-0.4	-0.3	-0.1	-0.6	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	0.0	0.9	0.4	0.7	0.0	0.0	0.0	0.7	0.6	0.7	0.9
Systolic Blood Pressure	0.3	1.5	4.1	-2.0	-0.1	-0.8	-0.9	-1.4	-2.0	-1.4	-0.6	-1.4	-0.3	-1.0
Number of treatments/medications taken	0.3	0.5	1.8	-1.1	1.3	0.2	-0.5	-0.4	-1.1	-0.4	0.4	-0.4	0.6	-0.3
Systolic blood pressure, automated reading	0.3	0.7	2.8	-0.9	1.7	0.8	0.2	0.3	-0.2	1.0	1.3	0.5	0.8	0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	-0.7	-0.4	-0.6	-0.5	-0.3	-0.3	-0.4	-0.2	1.0	-0.4	-0.9
Vitamin and mineral supplements	0.3	0.4	1.0	-1.0	0.6	-1.0	0.3	-0.6	-0.0	0.5	-0.9	0.3	0.6	-0.2
Maternal smoking around birth	0.3	0.4	1.1	-0.4	1.0	0.0	-0.7	0.7	0.2	0.6	0.7	1.0	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.0	0.7	0.2	1.0	0.8	0.7	1.2	1.1	0.2	1.4	0.3	0.8
Medication: Levothyroxine sodium	0.3	0.6	1.7	0.6	0.5	0.6	1.3	0.5	0.5	0.4	0.2	0.7	1.1	1.1
Had other major operations	0.3	0.3	1.1	-0.3	-0.7	-0.5	-0.3	-0.6	-0.4	-0.8	-1.1	-0.4	-0.2	-0.1
Mouth/teeth dental problems	0.3	0.4	1.1	0.3	-1.0	-0.8	-0.1	-0.3	0.7	0.1	-1.1	0.2	-0.8	-0.6
Trunk fat-free mass	0.3	1.8	5.2	1.6	-1.5	-0.4	-1.1	1.5	2.3	1.3	0.9	1.3	-1.5	-0.2
Father’s age at death	0.3	0.5	2.1	0.3	-1.4	0.2	-0.2	-0.2	-0.3	-0.1	0.3	-1.0	-1.2	-0.2
Noisy workplace	0.3	0.4	0.9	-0.6	-0.4	-0.8	-0.9	-0.7	0.1	-0.1	-0.9	-0.4	-0.8	-0.8
Trunk predicted mass	0.3	1.7	5.1	1.5	-1.4	-0.4	-1.0	1.5	2.3	1.3	0.9	1.3	-1.4	-0.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.9	0.3	1.4	-0.1	0.7	0.4	0.8	0.6	-0.3	1.3	1.3	0.4
Gout (self-reported)	0.3	0.5	1.3	-0.4	-0.7	-1.1	-0.9	-0.4	-0.1	-0.5	-0.9	-0.4	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.8	-0.7	1.3	0.4	-0.0	-0.1	-0.8	-0.3	0.2	0.0	1.0	0.3
High blood pressure (siblings)	0.3	0.4	1.6	0.7	-1.3	-0.5	-0.3	-0.6	0.1	0.0	-1.1	0.0	-0.6	-0.3
Emphysema/chronic bronchitis	0.3	0.4	1.5	0.6	0.5	1.2	-0.1	0.5	0.3	0.5	0.9	-0.0	0.1	0.7
Medication: Blood pressure	0.3	0.4	2.0	0.1	1.4	0.6	0.7	0.1	-0.0	0.6	0.4	0.3	1.1	0.4
Illnesses of siblings: Diabetes	0.3	0.3	1.4	0.7	0.1	-0.1	-0.3	0.5	1.2	0.6	0.3	0.9	-0.5	-0.4
Loneliness, isolation	0.3	0.5	2.1	-0.1	-0.5	-0.5	-0.4	-0.3	-0.9	-1.5	-0.5	-0.9	-0.2	-0.4
Eye problems/disorders: Cataract	0.3	0.4	1.2	-0.2	-1.0	-0.5	-0.5	-0.4	-0.8	-1.1	-0.2	-0.5	-0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	0.6	-0.6	-0.3	0.8	0.1	-0.1	-0.8	-0.6	-0.3	0.5	0.6
Commuting to job workplace: Public transport	0.3	0.3	1.2	0.4	-1.1	-0.1	-0.3	0.0	0.9	0.7	-0.4	-0.1	-0.8	0.2
Medication: Blood pressure	0.3	0.5	1.8	0.7	-0.6	0.0	-0.3	0.4	1.3	1.1	0.0	1.3	-0.5	0.1
Number of operations (self-reported)	0.3	0.5	1.3	0.7	0.5	1.0	0.5	0.8	0.3	0.1	0.6	0.6	0.9	1.1
Irritability	0.3	0.6	1.4	-0.4	-0.4	-0.3	-0.7	-0.9	-0.7	-1.1	-1.2	-1.0	-0.5	-0.4
Age started oral contraceptive pill	0.3	0.4	0.7	0.6	-0.2	0.6	0.6	0.7	0.8	0.9	0.8	0.7	-0.0	0.6
Diastolic blood pressure, automated reading	0.3	0.9	3.8	-2.0	1.4	-0.5	-0.3	-0.4	-1.5	-0.1	0.8	-0.1	0.7	-0.7
Myopia	0.3	0.5	1.6	1.3	-0.6	0.8	0.1	0.3	0.9	0.3	-0.4	1.1	-0.4	0.3
Alcohol drinker status: Previous	0.3	0.4	1.3	0.7	0.3	0.4	1.1	0.5	-0.1	-0.2	0.3	-0.1	1.0	0.9
Bipolar Disorder (2018)	0.2	0.4	1.2	0.0	-0.9	-0.8	-0.7	-0.3	0.1	-0.1	-0.2	-0.7	-1.1	-0.8
Ulcerative Colitis (UC)	0.2	0.3	0.9	-1.0	0.9	-0.5	0.3	-0.4	0.0	0.3	-0.7	0.2	0.6	-0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.5	0.1	-0.6	-0.7	-0.4	-0.1	-0.1	-0.6	0.1	-0.3	-0.6
Mean Putamen Volume	0.2	0.2	0.8	-0.5	-0.1	-0.4	0.0	-0.6	-0.9	-0.6	-0.4	0.3	0.1	-0.5
Lupus	0.2	0.3	1.0	-1.0	0.9	-0.3	0.3	-0.1	-0.7	-0.3	-0.2	0.4	0.9	-0.1
Ulcerative Colitis	0.2	0.3	1.7	0.0	1.3	0.1	0.5	-0.5	-0.3	0.1	-0.4	0.0	0.8	0.0
Cardiovascular Disease	0.2	0.7	1.7	-0.8	-0.5	-0.9	-0.5	-0.8	-1.0	-1.3	-1.1	-0.7	-0.3	-0.8
Hand grip strength (left)	0.2	0.6	1.1	-0.8	-0.8	-0.6	-1.1	-0.2	-0.6	-0.9	0.1	-0.9	-0.9	-0.8
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.3	0.5	0.6	0.6	0.6	0.5	0.7	0.4	0.4	0.6	0.8
Medication for hormone replacement therapy	0.2	0.2	0.9	-0.2	1.0	0.4	-0.2	-0.6	-0.3	0.1	-0.5	-0.4	0.5	0.1
Medication: Co-codamol	0.2	0.2	0.5	-0.3	-0.1	0.2	-0.7	-0.4	-0.6	-0.4	0.2	-0.7	-0.3	-0.2
Average weekly fortified wine intake	0.2	0.2	0.7	0.6	-0.6	0.0	0.4	0.2	0.8	0.6	-0.3	0.6	-0.3	0.2
Relative age voice broke	0.2	0.3	1.0	0.6	-1.0	-0.4	0.4	0.5	0.6	0.3	-0.0	0.5	-0.0	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.7	-0.4	0.2	0.3	-0.8	0.1	-0.6	-0.3	0.8	-0.6	-0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.2	-0.3	-1.1	-0.5	-0.7	-0.4	-0.6	-1.1	-0.3	-0.9	-1.0	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.2	0.9	0.5	0.0	-0.1	-0.5	0.2	0.4	0.6	0.6	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.2	1.0	0.4	0.2	0.3	-0.6	-0.6	0.6	-0.2	0.8	0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.7	0.2	0.6	0.0	0.7	0.7	0.1	0.3	0.7	0.4	0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.3	0.3	0.3	0.7	0.7	-0.3	-0.8	0.5	-0.3	0.8	0.5
Qualifications: None of the above	0.2	0.5	0.9	0.8	-0.0	0.6	0.7	1.0	1.0	0.9	0.6	0.8	0.3	0.8
Financial difficulties in last 2 years	0.2	0.3	1.1	-0.6	1.0	0.7	0.4	-0.0	-0.3	0.1	-0.0	0.1	0.7	0.6
Time employed in main current job	0.2	0.2	0.8	-0.1	-0.3	-0.6	-0.3	-0.0	-0.9	-0.6	0.2	-0.8	-0.0	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.2	-0.2	0.4	-0.8	0.0	0.7	0.9	0.3	-0.1	-0.7	0.0
Falls in the last year	0.2	0.3	0.8	-0.3	0.9	0.3	0.4	0.3	0.0	0.5	0.4	0.3	0.9	0.7
Prospective memory result	0.2	0.2	0.9	0.1	0.5	0.9	0.2	0.2	0.3	0.4	0.4	-0.0	0.2	0.6
Breastfed as a baby	0.2	0.2	1.0	0.0	-0.4	-0.6	-0.1	-0.3	0.3	-0.3	-1.0	0.5	-0.3	-0.4
Birth weight of first child	0.2	0.4	1.1	-0.7	-0.4	-0.1	-0.3	-0.3	-1.0	-1.1	0.2	-1.1	-0.2	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	0.5	-0.5	0.4	0.2	0.6	1.0	0.5	0.2	0.6	-0.3	0.4
Glaucoma (self-reported)	0.2	0.2	0.6	-0.7	0.8	0.2	0.1	-0.2	-0.6	-0.5	-0.2	-0.4	0.5	0.2
Number of children fathered	0.2	0.2	0.6	-0.4	-0.3	-0.2	-0.4	-0.2	0.7	0.8	-0.2	0.2	-0.7	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.5	-0.0	0.5	0.8	0.1	-0.1	0.1	0.2	0.5	0.5	0.6
Health satisfaction	0.2	0.2	0.6	0.1	-0.2	0.4	0.7	0.4	-0.3	-0.0	0.8	-0.6	0.4	0.8
Medication: Allopurinol	0.2	0.3	0.5	-0.5	-0.5	-0.7	-0.7	-0.4	-0.4	-0.6	-0.5	-0.7	-0.5	-0.6
Alcohol intake frequency.	0.2	0.5	2.1	0.9	0.1	1.4	0.3	0.8	0.1	-0.0	0.9	-0.0	0.4	1.1
Comparative height size at age 10	0.2	1.4	5.1	1.3	-2.2	-0.1	-1.3	0.9	0.9	0.0	0.9	0.0	-2.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	0.2	-0.5	0.5	-0.5	0.1	-0.0	0.1	0.9	-0.9	-0.7	0.0
Long-standing illness, disability or infirmity	0.2	0.3	0.8	0.4	0.9	0.6	0.5	0.4	0.2	0.3	0.3	0.5	0.9	0.7
Friendships satisfaction	0.2	0.2	0.8	0.7	-0.9	-0.1	0.2	0.5	-0.1	-0.7	0.4	-0.4	-0.3	0.1
Medication for cholesterol	0.2	0.3	1.3	0.2	0.6	0.5	0.6	0.7	-0.2	-0.1	1.1	0.0	0.6	0.4
Medication: Aspirin	0.2	0.2	0.7	-0.9	0.8	0.2	-0.4	-0.7	-0.4	0.0	-0.3	-0.1	0.1	-0.3
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.2	-0.5	-0.9	-0.0	-0.0	-0.0	-0.6	-0.5	-0.4	-0.2	-0.5
Hearing aid user	0.2	0.2	0.5	0.7	-0.7	0.2	0.6	0.5	0.5	0.2	0.5	-0.0	-0.0	0.6
High cholesterol (Self-reported)	0.2	0.3	1.3	0.9	-0.3	0.0	1.2	0.5	0.0	-0.2	0.3	0.2	0.7	0.7
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.5	0.7	-0.0	0.4	-0.4	-0.7	-0.2	-0.3	-0.1	0.8	0.1
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	0.0	-0.3	-0.5	-0.2	-0.5	-0.1	0.1	-0.2	-0.4	-0.5	-0.5
Crohns Disease (2012)	0.1	0.1	0.3	0.0	-0.4	-0.3	-0.2	-0.1	0.5	0.5	-0.4	-0.2	-0.5	-0.2
Fasting Glucose	0.1	0.1	0.6	-0.5	0.8	0.3	-0.3	-0.2	-0.4	-0.1	-0.2	-0.1	0.2	-0.0
HDL Cholesterol	0.1	0.2	1.1	0.0	-0.1	-0.6	1.0	0.0	0.0	0.0	-0.3	0.0	0.7	0.3
Rheumatoid Arthritis	0.1	0.1	0.6	-0.1	0.1	-0.1	-0.7	-0.0	0.4	0.5	-0.1	0.3	-0.5	-0.5
Blood Eosinophil Count	0.1	0.8	3.0	-0.2	-1.7	-1.1	-0.6	-0.1	-0.4	-1.1	-0.2	-0.3	-1.2	-0.9
Blood White Count	0.1	0.4	1.0	-0.8	0.6	0.4	-1.0	-0.6	0.6	0.8	-0.7	0.3	-0.4	-0.2
Heel T-Score	0.1	0.6	2.2	-0.9	1.5	-0.2	0.8	-0.3	-0.3	0.6	-0.3	0.9	1.3	0.2
Lung FVC	0.1	0.6	1.6	-0.7	-0.2	-0.6	1.3	-0.7	-1.0	-0.9	-0.9	-0.7	0.6	0.1
Hair Pigment	0.1	3.0	5.2	-1.6	-1.5	-1.6	-2.1	-2.3	-1.0	-1.0	-1.9	-1.5	-2.1	-2.0
Medication: Metformin	0.1	0.1	0.3	-0.5	0.4	-0.1	0.1	-0.3	-0.3	-0.2	-0.1	0.2	0.5	0.0
Hand grip strength (right)	0.1	0.3	0.9	0.5	-0.4	0.2	-0.4	0.8	0.5	0.3	1.0	-0.1	-0.4	0.2
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.3	0.0	0.0	0.5	-0.3	-0.8	-0.7	-0.4	-0.1	0.6	0.3
Age when periods started (menarche)	0.1	0.2	0.8	-0.1	-0.9	-0.3	-0.2	-0.0	0.4	-0.3	-0.6	-0.2	-0.8	-0.2
High blood pressure	0.1	0.3	1.2	-0.5	1.1	-0.1	-0.1	0.0	0.1	0.7	0.1	0.7	0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.5	-0.7	0.0	-0.6	0.0	-0.1	-0.4	-0.0	0.5	-0.5	-0.1	-0.4
High blood pressure (mother)	0.1	0.2	0.6	-0.3	-0.1	-0.5	0.8	-0.1	-0.2	-0.5	-0.7	-0.4	0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	0.3	0.2	0.3	0.2	0.4	1.0	0.5	-0.1	1.0	-0.1	0.1
Allergy	0.1	0.3	1.1	-0.2	0.8	0.0	0.9	-0.1	-0.2	0.4	-0.1	0.1	1.1	0.5
Illnesses of siblings	0.1	0.2	0.4	-0.2	0.6	0.4	0.5	0.4	-0.3	-0.5	0.6	-0.6	0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.6	0.2	0.1	0.0	0.5	0.1	0.4	0.5	-0.1	0.8	0.2	0.0
Medication: Cholesterol lowering	0.1	0.2	0.5	0.2	0.5	0.2	0.4	0.2	-0.6	-0.4	0.5	-0.3	0.7	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	-0.7	0.1	-0.8	-0.2	-0.5	-0.2	-0.4	-0.7	-0.2	-0.1	-0.6
Wheeze or whistling in the chest in last year	0.1	0.3	0.9	0.4	0.2	0.8	-0.1	0.5	0.3	0.5	0.9	0.5	0.0	0.4
Age at first live birth	0.1	0.2	0.5	-0.2	0.3	-0.0	-0.4	-0.0	0.6	0.7	0.3	-0.1	-0.6	-0.5
Qualifications: College or University degree	0.1	0.3	1.1	-0.6	-1.0	-1.1	-0.1	-0.3	-0.0	0.1	-0.3	-0.5	-0.7	-0.6
Heart disease (mother)	0.1	0.1	0.5	-0.0	0.7	0.4	0.0	-0.2	0.2	0.5	-0.1	0.3	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.7	-0.1	-0.0	-0.4	0.6	0.5	-0.3	0.3	0.0	-0.3	-0.1
Medication: Aspirin	0.1	0.1	0.2	-0.3	0.4	0.4	-0.5	-0.3	0.1	0.2	0.0	-0.2	-0.2	-0.1
Hypertension (Self-reported)	0.1	0.1	0.5	-0.4	0.7	-0.2	-0.2	-0.2	0.1	0.4	-0.3	0.5	0.4	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.5	0.0	-0.0	0.3	0.1	0.5	0.1	-0.2	-0.1	0.1	0.2
Mother’s age at death	0.1	0.1	0.4	-0.1	-0.7	-0.3	0.6	-0.3	-0.2	-0.0	-0.5	-0.2	-0.1	0.1
Ever smoked	0.1	0.1	0.3	-0.3	0.5	0.6	0.4	-0.1	-0.4	-0.2	-0.0	-0.4	0.4	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	2.2	0.5	-1.5	-0.0	-0.1	-0.1	0.0	-0.5	-0.0	-0.8	-1.0	-0.0
Intelligence (Savage-Jansen 2018)	0.0	0.2	0.9	0.2	-1.0	-0.2	-0.3	-0.2	-0.3	-0.2	-0.1	-0.1	-0.6	-0.3
Schizophrenia (2018)	0.0	0.0	0.1	0.0	0.3	-0.2	0.0	-0.3	0.0	0.0	-0.1	0.2	0.1	-0.2
LDL Cholesterol	0.0	0.1	0.5	0.0	-0.1	-0.1	0.7	0.0	0.0	0.0	-0.2	-0.0	0.2	0.3
Respiratory disease	0.0	0.1	0.2	0.2	0.1	0.5	0.4	-0.1	-0.3	-0.3	-0.0	-0.0	0.4	0.4
Tanning	0.0	0.3	1.6	-0.5	0.1	-0.2	0.1	-0.9	-0.2	-0.1	-1.3	-0.2	-0.0	-0.2
Age at last live birth	0.0	0.1	0.2	-0.0	0.4	-0.1	-0.2	0.3	0.3	-0.1	0.2	-0.0	-0.2	-0.5
Breast cancer (self-reported)	0.0	0.1	0.2	0.2	-0.3	-0.2	-0.0	0.3	-0.1	0.0	0.5	-0.2	0.0	0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.2	0.5	-0.2	0.4	-0.1	0.0	0.2	0.2	0.3	0.0	-0.2	0.1
Risk taking	0.0	0.1	0.2	-0.2	-0.2	-0.1	-0.4	0.3	-0.1	-0.4	0.1	0.3	-0.2	-0.3

Hub : Genes

RDM1

Models

Trait associations