Hub : Genes

APCDD1L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0490	0.0205	1.1e-02	0.005	0.008	0.000	0.007	-0.001	5.2e-02	1.7e-02	3.1e-01	0.026	4.4e-01
2	TCGA	Bladder Urothelial Carcinoma	0.1670	0.0550	5.2e-04	0.060	0.035	0.063	NA	0.072	8.0e-06	5.3e-04	4.9e-06	NA	1.1e-06
3	TCGA	Breast Invasive Carcinoma	0.0366	0.0165	5.7e-03	0.006	0.006	0.002	NA	0.002	1.6e-02	2.1e-02	8.7e-02	NA	1.0e-01
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0690	0.0275	1.0e-03	0.022	0.018	0.037	NA	0.035	1.4e-03	3.8e-03	4.7e-05	NA	7.7e-05
5	TCGA	Prostate Adenocarcinoma	0.1477	0.0439	5.7e-07	0.006	0.069	0.069	NA	0.024	6.4e-02	1.0e-07	1.0e-07	NA	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	3.5	-1.9	0.7	0.7	0.6	1.3
Bipolar Disorder or Schizophrenia	0.9	2.1	5.4	-2.3	-1.0	0.6	0.6	1.9
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	-0.3	-0.8	-0.5	-1.2	-1.1
Depression (Nagel 2018)	1.0	1.6	4.6	-0.2	-2.1	-1.2	-1.1	-0.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.3	-1.0	1.5	1.0	-0.8	-0.2
Neuroticism (Nagel 2018)	0.5	1.1	1.8	1.3	-1.3	-0.9	-0.5	-1.1
Schizophrenia (2018)	0.7	1.5	2.6	-1.5	-1.6	0.2	0.7	1.4
Schizophrenia vs Biploar Disorder	1.3	1.7	3.9	-1.7	-1.2	-0.3	0.7	2.0
Worry (Nagel 2018)	0.5	1.1	4.2	2.0	-0.8	-0.3	0.1	0.6
Alzheimer’s Disease (in mother)	1.5	1.8	4.8	1.3	2.2	0.9	-0.4	1.1
Alzheimer’s Disease (in father)	0.6	0.7	1.6	0.3	0.8	1.2	0.9	-0.5
Alzheimer’s Disease (including proxy)	1.4	2.1	4.6	0.9	2.1	2.1	0.5	0.7
Crohns Disease (2017)	0.5	1.2	2.7	1.1	-0.8	0.5	1.1	1.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.6	-0.7	-0.3	-0.3	-0.2
Ulcerative Colitis (UC)	0.7	1.4	3.6	-1.3	-0.5	-0.6	-1.0	-1.9
Major Depression (MDD)	1.5	1.8	2.9	-0.9	1.6	1.6	1.7	0.5
Reaction Time	0.2	0.3	0.8	-0.9	-0.6	0.1	0.6	-0.4
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.6	-0.2	1.7	0.0	-1.9	0.8
Breast Cancer	1.0	2.4	6.0	1.0	0.4	2.4	2.2	-0.1
Ovarian Cancer	1.1	1.4	2.6	-1.4	1.6	-0.9	-1.3	-0.1
Prostate Cancer	0.7	1.0	2.1	-1.4	0.7	-0.4	-1.5	0.0
Age at First Birth	0.2	0.4	1.5	-1.2	-0.5	-0.2	-0.0	0.1
Bipolar Disorder (2011)	1.0	1.0	5.0	-2.2	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	0.2	-0.7	-0.2	0.8	-0.9
Coronary Artery Disease (CAD)	1.1	1.3	3.2	1.0	-1.5	-0.1	0.5	-1.8
Crohns Disease (2012)	0.4	0.7	3.1	-0.0	-0.4	0.0	0.3	1.8
Mean Putamen Volume	0.9	1.0	2.3	-1.5	-0.1	-0.6	-1.5	-0.2
Fasting Glucose	0.5	0.6	1.1	0.4	1.0	1.1	0.7	0.5
HbA1C	1.2	1.4	3.6	1.4	-0.9	0.3	1.9	0.6
HDL Cholesterol	0.4	0.7	2.2	1.5	-0.3	-0.8	-0.7	0.5
LDL Cholesterol	0.3	0.5	1.5	-0.6	0.3	-0.4	-0.8	-1.2
Lupus	1.3	2.0	4.4	-2.1	-0.5	-1.9	-1.1	-0.7
Neuroticism (2016)	0.8	1.2	2.7	1.6	0.6	1.2	0.3	-1.2
Primary Biliary Cirrhosis	0.4	0.6	2.6	-0.1	1.6	0.5	0.1	0.2
Rheumatoid Arthritis	1.0	1.3	5.0	2.2	0.2	-0.2	-0.5	1.1
Schizophrenia (2014)	1.0	2.2	8.6	-2.9	-0.8	0.2	0.7	1.2
Triglycerides	1.3	2.1	3.7	-1.1	0.2	-1.7	-1.9	-1.7
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.3	-0.9	-0.3	-1.1	-0.4	0.5
Ulcerative Colitis	1.0	1.4	2.5	-1.6	-0.1	-1.0	-1.2	-1.4
Blood Eosinophil Count	0.2	1.7	3.5	1.9	-0.4	1.0	1.2	1.6
Blood Platelet Count	1.2	13.4	62.1	7.9	0.5	-0.1	1.7	-1.4
Blood Red Count	0.1	0.8	3.4	-0.5	-0.0	0.0	0.6	-1.8
Blood White Count	0.2	1.7	5.4	2.3	-0.3	-0.9	1.3	-0.6
Heel T-Score	0.2	1.6	5.3	-0.1	0.2	0.1	1.6	-2.3
BMI	0.4	2.3	9.3	-0.3	-1.2	-0.7	0.4	-3.1
Height	0.2	3.1	9.2	-3.0	1.3	0.0	0.4	2.0
Waist Hip Ratio (WHR)	0.1	0.3	1.0	0.5	0.2	-0.2	1.0	-0.5
Systolic Blood Pressure	0.3	1.6	7.3	2.7	0.4	-0.6	0.1	0.3
Smoking Status	0.2	0.5	1.5	1.2	-0.1	-0.7	0.3	0.5
Allergy or Eczema	0.1	0.4	0.8	0.7	0.6	0.9	-0.1	-0.4
Cardiovascular Disease	0.5	1.5	4.3	1.7	2.1	-0.1	0.6	-0.3
Hypothyroidism (self reported)	0.4	0.8	2.8	0.3	-0.8	-0.5	-1.7	0.6
Respiratory disease	0.4	0.9	3.2	-1.0	-0.1	-0.6	-1.8	0.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.0	0.2	0.1	-1.7	-1.1	0.7
Lung FEV1/FVC ratio	0.3	1.5	4.8	1.4	-0.4	-0.5	0.4	-2.2
Lung FVC	0.3	1.7	5.6	0.4	2.4	1.5	0.8	-0.3
Neuroticism	0.2	0.5	1.6	1.3	-0.5	-0.1	0.3	0.6
Chronotype (morning person)	1.3	3.0	8.0	-0.3	-0.5	-2.5	-2.8	-0.8
Hair Pigment	0.0	0.9	4.0	-2.0	0.1	0.0	0.6	0.1
Tanning	0.1	1.3	3.4	1.9	1.1	0.3	-0.8	1.0
Hand grip strength (left)	0.5	1.3	2.8	-1.7	1.5	0.3	1.0	0.5
Number of treatments/medications taken	0.6	1.2	2.7	0.7	-0.4	-1.6	-1.6	-0.2
Average weekly spirits intake	0.1	0.1	0.3	-0.1	0.4	0.0	-0.6	0.5
Sensitivity / hurt feelings	0.6	1.1	1.9	1.3	-0.2	0.2	1.4	-1.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	4.0	0.3	-2.0	-1.1	-1.5	-0.2
Hearing difficulty/problems: Yes	0.7	1.0	2.9	0.2	-1.7	0.6	-0.5	1.2
Relative age of first facial hair	0.4	0.9	1.5	-0.9	0.7	-0.1	-1.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	-0.2	-1.0	-0.6	0.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.6	2.6	-0.2	-0.1	0.2	-0.3	1.6
Ever had hysterectomy (womb removed)	1.7	1.9	8.1	-2.8	-0.9	-0.2	-0.5	0.5
Systolic blood pressure, automated reading	0.2	0.6	1.0	0.8	0.4	-1.0	-0.6	0.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	6.7	-0.1	-2.6	-0.8	0.7	-0.8
Angina	0.6	0.8	2.3	-0.4	1.1	-1.5	-0.7	-0.3
Medication for hormone replacement therapy	0.5	0.6	1.6	-0.1	-0.6	1.1	1.3	0.1
Vitamin and mineral supplements	1.1	1.4	2.6	1.0	-0.4	-1.2	-1.4	-1.6
Supplements: Zinc	1.2	1.3	4.3	-2.1	-1.3	-0.3	0.0	-0.6
Medication: Co-codamol	1.9	2.2	5.5	0.3	-1.1	-2.1	-2.3	0.5
Medication: Metformin	3.1	4.4	12.2	-1.4	-0.6	-3.5	-2.1	-1.8
Diabetes (father)	0.4	0.5	1.2	1.0	-0.0	1.1	0.7	0.1
Diabetes (mother)	0.7	0.9	2.5	0.8	1.6	0.3	1.1	-0.3
Severe depression (siblings)	1.6	1.8	3.3	1.4	-1.1	-1.4	-0.6	-1.8
Pack years adult smoking proportion	0.4	0.6	1.5	0.2	1.2	0.8	0.8	0.1
Impedance of leg (right)	0.2	1.1	3.2	0.7	1.1	0.4	0.6	1.8
Leg fat-free mass (left)	0.3	1.7	2.6	-1.5	-1.4	0.7	1.1	-1.6
Trunk fat percentage	0.3	1.2	4.5	0.5	-1.0	0.0	0.2	-2.1
Hand grip strength (right)	0.5	1.5	3.8	-1.6	1.0	0.5	1.9	0.1
Townsend deprivation index at recruitment	0.5	0.8	2.5	1.6	0.0	-0.7	-0.6	-0.7
Current tobacco smoking	0.6	1.0	2.7	1.6	-0.0	0.5	1.4	0.6
Average weekly fortified wine intake	0.4	0.5	2.0	-0.5	0.1	-1.4	-0.3	-0.3
Maternal smoking around birth	0.9	1.3	2.2	-1.0	1.4	0.8	1.5	0.9
Fed-up feelings	0.4	0.8	1.3	1.1	-1.0	-0.0	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	6.9	0.9	-2.6	-0.4	0.2	-0.1
Relative age voice broke	1.2	1.8	8.2	-2.9	-0.4	0.7	0.5	0.3
Taking other prescription medications	0.7	1.1	2.8	-0.3	0.5	-1.6	-1.7	0.2
Age when periods started (menarche)	0.2	0.4	0.8	0.3	0.9	-0.5	-0.8	-0.3
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	7.2	-2.7	-0.1	0.3	0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.6	1.6	1.6	-0.2	0.8	-0.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.6	-1.2	-1.9	1.4	1.2	0.8
Qualifications: CSEs or equivalent	0.5	0.7	1.6	0.0	1.3	-0.7	-1.0	-0.6
Serious illness, injury or assault to yourself	0.7	0.8	2.2	0.1	0.7	-1.5	-1.1	0.5
High blood pressure	0.5	1.5	4.3	2.1	1.5	0.1	0.9	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.1	0.6	0.4	-0.5	-0.5
Multivitamins +/- minerals	0.4	0.5	1.0	-1.0	-0.8	0.4	0.6	0.7
Stomach or abdominal pain in last month	0.4	0.5	1.0	-0.8	-1.0	-0.3	0.1	-0.8
Supplements: Glucosamine	0.2	0.2	0.5	-0.1	-0.7	0.3	0.7	0.2
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.6	1.0	-0.9	1.2	2.2	0.6
Medication: Atenolol	2.0	2.5	8.8	-1.1	0.7	-1.2	-3.0	-0.6
Medication: Levothyroxine sodium	1.0	1.7	2.7	1.1	1.5	0.6	-1.3	1.6
Sitting height	0.4	2.7	5.8	-2.4	1.3	1.2	1.1	1.8
Chronic bronchitis/emphysema (father)	1.6	1.8	5.5	-0.2	-2.3	-1.6	-0.4	0.9
High blood pressure (mother)	0.6	0.8	1.5	-0.6	0.4	-1.2	-1.1	0.8
Body mass index (BMI)	0.6	2.4	8.9	0.1	-1.6	-0.8	0.0	-3.0
Impedance of leg (left)	0.2	1.0	3.4	-0.1	1.2	-0.0	-0.0	1.8
Leg predicted mass (left)	0.3	1.7	2.5	-1.6	-1.5	0.7	1.1	-1.5
Trunk fat mass	0.3	1.2	4.3	-0.1	-1.2	0.1	0.6	-2.1
Waist circumference	0.5	1.9	7.1	0.4	-1.1	-0.3	0.9	-2.7
Number of incorrect matches in round	0.4	0.7	1.6	0.7	-1.3	-0.7	-0.2	-1.0
Past tobacco smoking	0.3	0.5	1.2	-0.7	0.4	0.1	-0.9	1.1
Alcohol usually taken with meals	0.1	0.2	0.4	0.3	-0.7	0.4	-0.5	-0.0
Nervous feelings	0.6	1.1	4.6	2.1	-0.1	0.4	0.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.2	1.0	-1.5	-1.0	-0.7	-0.3
Hearing difficulty/problems with background noise	0.6	1.0	2.5	0.3	-1.6	0.9	0.9	0.9
Hair/balding pattern: Pattern 2	1.0	1.3	2.0	-1.4	1.4	0.8	-0.4	1.4
Had menopause	0.5	0.6	2.1	0.4	0.1	-0.2	-1.5	0.7
Had other major operations	2.1	2.6	5.3	2.1	-0.8	-2.3	-1.5	-0.8
Forced vital capacity (FVC)	0.3	1.2	3.2	-1.8	0.6	0.9	0.9	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.1	1.2	1.8	-0.3	1.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.7	0.3	-0.1	0.2	0.5	-1.3
Qualifications: None of the above	0.7	1.5	5.8	2.4	-0.3	-0.9	0.2	-0.9
Financial difficulties in last 2 years	0.3	0.4	1.8	0.4	0.2	1.4	0.1	0.4
Mouth/teeth dental problems	0.5	0.7	2.0	0.4	0.8	0.6	1.4	-0.8
Heart attack	0.3	0.4	0.7	0.8	0.8	0.4	-0.4	0.3
Allergy	0.1	0.3	0.6	0.4	-0.7	-0.3	0.5	0.8
Pain all over the body in last month	0.4	0.5	1.6	-1.3	-0.3	-0.5	-0.5	-0.2
Diabetes (self-reported)	1.4	2.2	7.6	-0.3	-0.6	-2.8	-1.4	-1.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.2	0.5	1.8	0.6	0.9	-0.6
Medication: Ramipril	0.7	0.9	3.1	0.4	1.8	-0.6	-1.0	-0.1
Medication: Simvastatin	1.4	2.0	4.9	0.8	-0.7	-1.5	-1.3	-2.2
Fluid intelligence score	0.3	0.7	1.4	-1.1	0.8	0.2	-1.2	0.1
Illnesses of siblings	0.4	0.5	1.7	-0.6	-0.2	0.6	1.3	-0.2
Neuroticism score	0.2	0.4	1.2	1.0	-1.1	-0.2	0.2	-0.1
Weight	0.3	1.6	4.5	-0.8	-1.4	-0.1	0.7	-2.1
Impedance of arm (right)	0.4	1.8	3.9	1.7	0.2	1.4	0.1	2.0
Arm fat percentage (right)	0.5	2.0	6.1	1.1	-1.5	0.4	0.3	-2.5
Trunk fat-free mass	0.3	1.5	4.6	-2.1	-0.7	0.7	1.0	-1.1
Hip circumference	0.4	1.8	7.0	-0.2	-1.2	0.2	0.5	-2.6
Time employed in main current job	1.4	1.6	5.3	-0.3	0.7	-1.3	-2.3	-0.5
Alcohol intake versus 10 years previously	0.8	1.3	2.8	-1.7	1.5	0.5	0.1	1.0
Father’s age at death	0.9	1.2	2.5	-0.9	-1.1	-0.3	-1.6	1.2
Worrier / anxious feelings	0.4	0.7	2.2	1.5	0.9	0.2	0.8	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.8	0.5	-0.4	0.5	1.3	-0.5
Falls in the last year	0.6	0.7	1.2	0.8	-1.0	-1.1	-0.6	0.7
Hair/balding pattern: Pattern 3	0.7	1.1	3.1	0.1	-1.3	-0.5	0.5	-1.7
Number of live births	0.4	0.6	1.2	-0.2	-0.9	-1.1	0.5	-1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.8	-0.7	0.4	1.3	1.3	0.2
Pulse rate	0.6	1.0	2.3	1.5	-0.1	-1.5	0.4	-0.5
Happiness	0.8	1.0	2.3	0.3	0.4	0.7	-1.4	1.5
Noisy workplace	0.4	0.5	0.9	0.4	1.0	0.1	0.9	0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.9	-1.6	0.5	0.3	-0.5	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	1.2	1.3	0.4	-0.4	0.1
Mouth/teeth dental problems: Dentures	0.7	1.2	3.5	0.1	-1.3	-1.9	-0.3	-0.7
Asthma	0.4	0.9	2.6	-1.1	-0.2	-0.7	-1.6	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.7	-0.3	-1.3	1.0	1.2	-0.0
Medication: Cholesterol lowering	0.4	0.6	1.4	0.8	1.2	-0.6	-0.2	0.6
Depression (self-reported)	0.3	0.4	1.5	-0.4	-0.2	-0.3	-1.2	0.0
Medication: Lansoprazole	0.4	0.5	1.4	0.4	-0.6	0.5	-0.2	1.2
Prospective memory result	0.3	0.4	0.9	0.9	-0.5	-0.3	-0.6	0.6
Lung cancer (father)	1.1	1.2	2.2	-1.1	-0.9	-1.4	-1.5	0.4
Illnesses of mother	1.5	1.8	6.9	-1.0	-2.6	-0.5	-0.9	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.5	-0.4	0.3	2.1	2.0	-0.0
Pulse wave Arterial Stiffness index	1.0	1.2	4.1	0.4	-2.0	0.6	1.1	0.0
Impedance of arm (left)	0.4	1.8	3.5	1.9	0.3	1.6	0.7	1.5
Arm fat mass (right)	0.4	1.5	5.8	0.1	-1.3	0.1	0.4	-2.4
Trunk predicted mass	0.3	1.5	4.4	-2.1	-0.7	0.7	1.0	-1.0
Standing height	0.3	2.9	5.5	-2.3	0.3	1.7	1.9	1.6
Length of working week for main job	0.6	0.7	2.2	0.7	0.1	0.0	0.7	1.5
Exposure to tobacco smoke at home	0.4	0.4	1.2	0.6	0.3	0.7	1.1	-0.2
Breastfed as a baby	1.0	1.3	3.2	-0.3	-1.7	-0.4	-0.5	-1.8
Tense / ‘highly strung’	0.4	0.7	1.5	1.1	-0.5	-0.7	-1.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.3	1.1	-0.8	-1.5	-0.9	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	-0.7	0.8	-0.3	-0.3	-0.6
Birth weight of first child	0.4	0.7	3.3	-0.3	0.4	0.4	-0.1	-1.8
Peak expiratory flow (PEF)	0.9	2.0	3.8	0.0	0.7	2.0	1.8	1.6
Pulse wave reflection index	1.4	1.8	7.6	-0.9	-2.8	0.1	-0.2	0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.5	1.4	-1.0	-1.6	-0.8	-0.5
Loud music exposure frequency	0.5	0.6	1.1	-1.0	0.2	-0.6	0.6	-1.0
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.0	-0.5	-0.3	-1.9	-2.2	-0.7
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.7	0.7	0.1	1.9	0.0	1.8
Blood clot in the leg (DVT)	0.3	0.4	1.5	-0.4	-0.7	-0.1	1.2	0.2
Medication: Paracetamol	0.1	0.2	0.6	-0.8	-0.5	-0.0	-0.2	0.2
Headache pain in last month	0.2	0.3	0.8	-0.9	0.6	-0.1	-0.0	0.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.0	-1.7	-1.3	1.2	-0.3	-0.4
Glaucoma (self-reported)	0.4	0.5	1.5	-0.8	0.4	0.4	-0.0	-1.2
Gout (self-reported)	0.1	0.2	0.3	0.5	-0.3	-0.1	0.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.1	0.6	0.4	-0.2	-1.0	1.0
Medication: Amlodipine	0.8	1.2	2.4	1.1	-1.3	-0.6	0.3	-1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.6	4.4	0.3	2.1	0.9	0.4	1.6
Birth weight	0.3	0.7	1.7	0.7	0.1	1.3	-0.8	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.6	2.2	1.5	0.2	0.6	0.8	-0.2
High blood pressure (siblings)	0.7	1.0	1.6	0.5	-1.2	-1.3	-1.3	0.3
Forced vital capacity (FVC), Best measure	0.5	1.7	3.4	-1.7	0.6	1.8	1.3	0.4
Body fat percentage	0.5	1.9	6.9	0.6	-1.4	-0.2	0.2	-2.6
Leg fat percentage (right)	0.5	1.9	7.0	0.6	-1.4	-0.3	0.4	-2.6
Arm fat-free mass (right)	0.3	1.8	6.2	-2.5	-0.4	0.5	1.1	-1.0
Exposure to tobacco smoke outside home	0.5	0.6	1.2	-1.1	-0.8	0.3	-1.0	0.2
Comparative body size at age 10	0.5	1.4	4.2	0.7	-0.8	2.1	1.2	0.1
Number of full brothers	1.0	1.3	5.1	0.3	-0.3	-2.3	-1.1	0.4
Worry too long after embarrassment	0.6	1.1	2.7	-0.1	-0.9	-1.0	-1.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.7	0.8	0.8	0.5	0.4	0.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	-0.2	0.2	-1.2	-0.7	-1.6
Number of children fathered	0.2	0.2	0.6	-0.3	0.7	-0.8	0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.7	-0.8	-1.6	-1.1	-1.9	0.1
Age at first live birth	0.6	1.0	2.6	-1.3	0.8	0.2	-0.1	-1.6
Pulse wave peak to peak time	0.9	1.1	4.2	-0.6	2.1	-0.3	-0.9	0.1
Health satisfaction	0.3	0.3	1.1	0.0	0.6	1.0	0.3	-0.4
Shortness of breath walking on level ground	0.1	0.2	0.6	-0.1	0.8	-0.3	-0.3	-0.1
Qualifications: College or University degree	0.4	1.3	5.8	-2.4	-0.2	-0.2	-0.0	-0.8
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.2	-1.1	-0.0	-0.5	-0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	-0.8	0.4	0.6	0.9	-0.5
Emphysema/chronic bronchitis	0.8	0.9	1.8	0.8	1.3	-0.2	-1.4	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	2.0	-0.2	1.4	-0.0	-0.1	1.2
Neck or shoulder pain in last month	0.2	0.2	0.5	0.7	0.2	-0.7	0.2	-0.1
Medication: Blood pressure	1.2	2.1	6.5	2.6	1.5	-0.2	1.3	-0.0
Angina (self-reported)	0.9	1.2	2.8	-0.5	1.4	-1.7	-0.7	-0.4
Migraine (self-reported)	0.5	0.6	2.2	0.1	0.4	1.5	0.1	0.7
Medication: Ibuprofen	0.3	0.3	1.0	-0.4	-1.0	0.6	0.4	0.2
Medication: Allopurinol	0.8	1.0	2.0	-1.1	-1.3	-1.4	-0.4	0.1
Medication: Omeprazole	1.4	1.6	5.1	1.5	0.4	-0.2	-0.7	-2.3
Medication: Seretide 50 evohaler	1.2	1.3	3.1	1.2	-1.3	-0.6	-0.0	-1.8
Mean time to correctly identify matches	0.2	0.4	0.8	0.1	-0.9	-0.8	-0.6	0.4
Heart disease (mother)	1.5	1.8	6.0	1.0	1.2	0.4	0.8	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.3	-1.3	-0.9	-0.6	-0.5
Whole body fat mass	0.4	1.7	6.3	-0.3	-1.4	-0.0	0.6	-2.5
Leg fat mass (right)	0.4	1.7	5.7	-0.3	-1.5	-0.2	0.6	-2.4
Arm predicted mass (right)	0.3	1.7	5.6	-2.4	-0.6	0.4	0.9	-1.2
Pulse rate, automated reading	0.4	1.4	3.2	1.8	-0.6	-0.5	1.8	-0.1
Alcohol intake frequency.	0.4	1.0	2.5	0.4	-0.6	-1.6	-0.3	-1.3
Comparative height size at age 10	0.2	1.2	2.2	-0.6	1.1	1.5	1.4	0.6
Number of full sisters	0.4	0.4	1.4	-0.7	0.1	0.6	1.2	-0.0
Suffer from ‘nerves’	1.1	1.7	4.0	1.8	-0.9	-2.0	-0.8	-0.4
Overall health rating	0.1	0.1	0.3	-0.2	0.0	0.5	0.4	0.3
Chest pain or discomfort	0.9	1.3	2.5	-1.4	-0.8	-0.5	1.0	-1.6
Had major operations	0.4	0.4	1.5	0.4	1.2	0.0	0.7	-0.4
Age at last live birth	0.7	1.1	2.0	-1.4	1.0	0.3	1.0	-1.1
Family relationship satisfaction	0.8	1.0	2.1	-0.2	-0.4	-1.4	-1.5	0.9
Leg pain on walking	0.7	0.8	1.3	0.2	-1.0	-1.2	-0.9	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.3	0.2	0.2	0.0	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.2	-0.9	0.1	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.5	-0.7	-0.1	-0.0	0.2	-0.1
Medication: Aspirin	0.5	0.6	2.0	0.5	1.4	-0.4	0.2	-0.8
Supplements: Vitamin C	1.7	2.1	8.4	-2.9	1.4	0.2	0.1	0.2
Knee pain experienced in last month	0.9	1.4	3.0	1.3	-1.0	1.7	0.8	1.0
Hypertension (Self-reported)	0.4	1.1	3.6	1.9	1.3	-0.3	0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.8	1.9	0.3	0.9	0.8	-1.3
Illnesses of father: Heart disease	0.7	1.0	2.8	-0.1	0.4	-1.7	-1.4	0.1
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.3	1.0	0.8	0.2	-0.4
Smoking status: Previous	0.4	0.6	1.1	0.6	-1.0	-1.0	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.5	-1.3	-1.1	0.7	1.1	1.6
Whole body fat-free mass	0.3	1.6	4.1	-2.0	-1.0	0.6	1.0	-1.2
Leg fat-free mass (right)	0.3	1.6	3.8	-1.9	-1.3	0.4	0.8	-1.4
Arm fat percentage (left)	0.6	2.2	6.8	1.1	-1.6	0.6	0.6	-2.6
Average weekly red wine intake	0.8	1.2	3.1	0.4	0.1	1.6	1.7	-0.1
Handedness (chirality/laterality): Left-handed	1.7	2.0	5.9	0.6	2.4	0.9	1.5	0.8
Mood swings	0.8	1.4	3.0	-1.5	-0.6	-1.1	-1.7	-0.5
Loneliness, isolation	1.0	1.3	3.9	0.7	-2.0	-0.9	-0.9	-0.7
Long-standing illness, disability or infirmity	1.1	1.7	3.8	0.3	1.3	-1.6	-2.0	0.6
Ever had bowel cancer screening	0.8	0.9	2.6	1.6	0.6	-0.9	-0.4	0.9
Diabetes diagnosed by doctor	1.5	2.5	8.2	-0.5	-0.5	-2.9	-1.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.9	-0.1	-0.4	-1.4	-1.2	0.8
Friendships satisfaction	1.0	1.3	3.8	0.2	-0.9	-1.9	-1.2	-0.7
Qualifications: nursing, teaching	0.6	0.9	2.7	-1.7	-0.4	0.8	0.8	-0.4
Commuting to job workplace: Walk	0.7	0.8	2.7	1.6	1.1	-0.4	0.1	0.3
Eye problems/disorders: Cataract	0.7	0.9	1.7	1.1	0.7	-0.4	1.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.4	-1.5	-0.3	0.0	-1.1	0.5
Medication for cholesterol	0.8	1.2	3.9	-1.4	-0.3	-0.1	0.2	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.5	-0.2	-1.2	0.5	0.5	-0.3
Back pain experienced in last month	0.4	0.6	1.6	-0.2	-1.2	-0.3	1.1	0.6
Mineral and other dietary supplements	0.4	0.5	0.9	0.3	0.8	-0.4	-0.9	1.0
Breast cancer (self-reported)	0.2	0.3	1.2	0.4	0.1	0.1	-1.1	-0.1
Asthma (self-reported)	0.6	1.1	3.7	-0.9	-0.3	-1.0	-1.9	-0.0
Osteoporosis (self-reported)	1.1	1.3	4.2	-0.8	-2.1	-0.8	-0.1	-1.0
Osteoarthritis (self-reported)	0.8	1.1	2.2	1.1	-0.5	-0.7	-1.5	-1.2
Medication: Aspirin	0.5	0.6	1.5	1.0	1.2	-0.5	0.2	-0.6
Medication: Gliclazide	1.0	1.1	2.3	-0.3	-0.3	-1.5	-1.0	-1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	2.9	-1.7	0.5	0.6	0.2	-0.0
Smoking status: Current	0.8	1.2	3.0	1.5	0.3	0.7	1.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.9	0.4	0.8	1.5	1.7	0.1
Whole body water mass	0.3	1.5	3.9	-2.0	-1.0	0.5	0.9	-1.2
Leg predicted mass (right)	0.3	1.7	4.0	-2.0	-1.3	0.5	0.8	-1.4
Arm fat mass (left)	0.4	1.6	5.1	0.0	-1.5	0.4	0.7	-2.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.9	0.1	-0.1	-0.4	-0.4	-0.9
Average weekly champagne plus white wine intake	0.3	0.4	1.4	0.9	-0.0	0.3	-1.2	-0.1
Miserableness	0.2	0.3	0.8	-0.2	-0.9	-0.2	-0.4	-0.7
Guilty feelings	0.3	0.5	1.4	0.0	-0.7	-1.2	-0.7	-0.3
Wears glasses or contact lenses	1.1	1.2	2.8	1.0	0.9	-0.6	-1.1	1.7
Ever taken oral contraceptive pill	0.3	0.4	1.2	-0.4	-0.5	-0.4	-1.1	0.2
Hearing aid user	1.8	2.1	4.4	-0.7	-1.4	-1.7	-2.1	0.8
Mother’s age at death	0.5	0.6	1.6	0.4	-1.1	-0.2	-0.5	1.3
Financial situation satisfaction	0.8	1.0	2.9	-1.7	1.2	-0.5	-0.6	0.0
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.9	2.0	1.4	1.3	1.0	-0.7
Commuting to job workplace: Public transport	0.6	0.7	1.7	1.3	1.2	0.6	-0.5	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.4	0.1	1.2	0.4	0.3	-1.1
Medication: Blood pressure	0.6	1.2	2.1	1.3	1.0	-0.2	-1.0	-1.4
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.6	-0.6	0.1	-1.9	-1.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.4	-0.2	0.4	0.2	-0.5
High cholesterol (Self-reported)	0.6	1.1	4.3	0.1	0.6	-0.5	-0.5	-2.1
Medication: Bendroflumethiazide	0.5	0.7	2.3	0.3	-1.1	-1.5	0.2	-0.2
Medication: Paracetamol	0.6	0.9	1.8	-1.1	-1.3	-0.6	-1.1	0.1
Medication: Lisinopril	0.2	0.3	1.0	-0.4	-0.1	-0.3	1.0	-0.2
Medication: Atorvastatin	1.3	1.6	3.1	-1.1	1.8	-1.1	-0.1	1.5
Illnesses of father: High blood pressure	0.5	0.6	1.5	1.2	0.0	-0.0	-0.3	-1.2
Alcohol drinker status: Never	1.6	1.9	3.8	1.3	0.7	0.5	1.9	-1.8
Ever smoked	0.5	0.8	1.6	1.1	-0.9	0.1	0.8	-1.3
Basal metabolic rate	0.3	1.7	3.3	-1.8	-1.3	0.5	1.0	-1.5
Leg fat percentage (left)	0.5	1.7	6.0	-0.0	-1.4	-0.6	-0.1	-2.5
Arm fat-free mass (left)	0.3	1.3	4.4	-2.1	-0.9	0.1	0.4	-1.1
Number of operations (self-reported)	0.8	1.2	2.1	1.1	-1.2	-1.5	-0.9	0.5
Average weekly beer plus cider intake	0.4	0.6	1.4	-1.2	0.8	-0.3	0.3	0.9
Irritability	0.4	0.6	1.3	1.0	-0.8	1.1	0.4	0.2
Risk taking	0.6	0.9	2.3	-1.5	-0.7	-0.7	-0.7	0.9
Ever had prostate specific antigen (PSA) test	1.6	1.9	4.7	0.0	-1.4	-2.2	-1.0	-1.3
Fractured/broken bones in last 5 years	0.8	1.1	3.0	0.0	-0.2	-1.5	-0.4	-1.7
Age started oral contraceptive pill	0.2	0.3	1.0	-0.4	-1.0	-0.0	-0.1	-0.1
Diastolic blood pressure, automated reading	0.1	0.5	1.1	0.8	0.1	-0.5	1.1	0.6
Ever depressed for a whole week	0.1	0.1	0.4	-0.5	-0.1	0.6	0.3	0.1
Unable to work because of sickness or disability	0.6	0.8	2.1	-0.5	-0.0	-1.2	-1.4	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.7	-0.1	0.1	-0.0	0.8	0.0
Myopia	1.0	1.5	4.0	-0.6	-1.1	-0.7	-1.2	2.0
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.1	-2.5	-1.9	-0.1	-1.1	0.5
Cholesterol lowering medication	2.7	4.0	11.9	0.2	0.8	-2.1	-1.7	-3.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.7	1.3	0.1	-0.1	-1.1	-2.4
Pain experienced in last month	0.3	0.5	1.5	-0.4	1.2	-0.3	-0.1	-0.9
Supplements: Calcium	2.6	2.8	7.8	-1.5	0.4	2.8	1.5	1.3
Basal cell carcinoma (self-reported)	0.9	1.0	3.0	1.7	1.0	0.1	-0.0	1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.5	0.7	0.0	-0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	-0.3	-0.9	-0.1	0.9	0.3
Heart disease (siblings)	1.0	1.2	2.1	-0.8	0.5	-1.1	-1.4	-1.5
Alcohol drinker status: Previous	0.4	0.5	1.2	0.1	-1.1	-0.9	0.5	0.1
Pack years of smoking	0.2	0.3	1.3	0.2	1.2	0.3	0.0	-0.0
Impedance of whole body	0.2	1.1	4.0	0.9	0.7	0.6	-0.1	2.0
Leg fat mass (left)	0.4	1.6	5.5	-0.6	-1.5	-0.4	0.2	-2.3
Arm predicted mass (left)	0.2	1.1	4.0	-2.0	-0.7	0.1	0.3	-1.0