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chr20:60,182,653-62,912,463

Best TWAS P=1.03e-18 · Best GWAS P=2.79e-17 conditioned to 0.0474

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ARFRP1	0.07	0.07	lasso	3	0.06	5.3e-08	-7.9	8.1	4.7e-16	-0.80	0.35	0.65	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LIME1	0.04	0.00	bslmm	439	0.01	3.3e-02	-7.3	6.2	5.0e-10	-0.65	0.08	0.73	FALSE
3	CommonMind	Brain Pre-frontal Cortex	STMN3	0.07	0.02	lasso	4	0.05	2.8e-06	-7.4	-7.2	8.5e-13	0.75	0.02	0.98	FALSE
4	GTEx	Adipose Visceral Omentum	GMEB2	0.19	0.01	enet	21	0.02	5.2e-02	-5.0	-6.3	2.9e-10	0.50	0.03	0.78	FALSE
5	GTEx	Artery Aorta	CABLES2	0.26	0.09	enet	28	0.16	3.6e-09	-4.0	5.4	7.2e-08	0.07	0.99	0.01	FALSE
6	GTEx	Artery Tibial	LAMA5	0.12	0.05	enet	15	0.04	7.4e-04	6.2	5.2	2.1e-07	0.07	0.58	0.06	FALSE
7	GTEx	Artery Tibial	CABLES2	0.21	0.18	enet	16	0.20	8.3e-16	5.7	6.5	6.7e-11	0.10	0.99	0.01	FALSE
8	GTEx	Artery Tibial	RP11-157P1.4	0.15	0.05	lasso	5	0.09	3.4e-07	5.9	6.4	1.6e-10	0.14	0.92	0.02	FALSE
9	GTEx	Artery Tibial	RP11-157P1.5	0.15	0.06	enet	3	0.03	2.2e-03	6.2	6.3	3.9e-10	0.09	0.71	0.06	FALSE
10	GTEx	Brain Cerebellar Hemisphere	STMN3	0.39	0.08	lasso	5	0.22	2.1e-06	-8.1	-7.2	4.5e-13	0.72	0.02	0.95	FALSE
11	GTEx	Brain Cerebellum	STMN3	0.33	0.12	lasso	10	0.20	1.8e-06	-7.3	-8.5	2.0e-17	0.82	0.02	0.98	FALSE
12	GTEx	Brain Cortex	STMN3	0.25	0.09	lasso	7	0.11	6.8e-04	-7.1	-7.0	3.3e-12	0.89	0.06	0.81	FALSE
13	GTEx	Breast Mammary Tissue	GMEB2	0.18	0.02	lasso	5	0.06	3.0e-04	-7.2	-6.9	5.9e-12	0.70	0.05	0.72	FALSE
14	GTEx	Breast Mammary Tissue (Female)	GMEB2	0.36	0.06	lasso	4	0.05	1.2e-02	-8.1	-7.5	8.6e-14	0.94	0.02	0.86	FALSE
15	GTEx	Cells Transformed fibroblasts	LAMA5	0.14	0.12	lasso	4	0.12	5.0e-09	6.3	-6.4	1.3e-10	-0.10	0.93	0.07	FALSE
16	GTEx	Cells Transformed fibroblasts	RP11-157P1.5	0.15	0.12	enet	15	0.10	7.3e-08	6.3	-5.4	6.7e-08	-0.08	0.90	0.09	FALSE
17	GTEx	Cells Transformed fibroblasts	CTD-3184A7.4	0.09	0.00	enet	28	0.00	1.4e-01	-6.7	-5.2	1.9e-07	0.52	0.05	0.62	FALSE
18	GTEx	Colon Sigmoid	CABLES2	0.29	0.08	lasso	11	0.08	6.3e-04	-3.6	5.6	1.7e-08	0.05	0.47	0.03	FALSE
19	GTEx	Colon Sigmoid	RGS19	0.27	0.07	enet	33	0.09	3.8e-04	-3.2	-5.3	1.4e-07	0.03	0.51	0.05	TRUE
20	GTEx	Esophagus Gastroesophageal Junction	CABLES2	0.25	0.10	lasso	4	0.15	4.8e-06	5.4	5.8	7.8e-09	0.08	0.68	0.02	FALSE
21	GTEx	Esophagus Mucosa	LAMA5	0.18	0.10	lasso	4	0.10	2.9e-07	6.4	-6.4	1.5e-10	-0.12	0.91	0.08	FALSE
22	GTEx	Esophagus Muscularis	CABLES2	0.28	0.23	lasso	6	0.35	5.4e-22	5.4	5.8	5.0e-09	0.07	1.00	0.00	FALSE
23	GTEx	Heart Atrial Appendage	CABLES2	0.17	0.02	lasso	6	0.05	3.7e-03	5.6	5.9	4.7e-09	0.08	0.40	0.04	FALSE
24	GTEx	Heart Atrial Appendage	RP11-157P1.5	0.29	0.22	lasso	9	0.21	6.1e-10	5.4	-5.2	2.0e-07	-0.12	0.98	0.01	FALSE
25	GTEx	Liver	LAMA5	0.35	0.11	lasso	5	0.08	2.4e-03	6.4	6.9	4.3e-12	0.12	0.32	0.07	TRUE
26	GTEx	Liver	RP11-157P1.5	0.39	0.18	lasso	9	0.27	3.1e-08	5.4	-6.3	3.4e-10	-0.11	0.82	0.04	FALSE
27	GTEx	Muscle Skeletal	CABLES2	0.10	0.02	lasso	4	0.04	2.1e-04	6.2	6.4	1.7e-10	0.11	0.66	0.05	FALSE
28	GTEx	Muscle Skeletal	RP11-157P1.5	0.14	0.02	enet	14	0.02	2.8e-03	5.4	-5.9	2.8e-09	-0.13	0.77	0.04	FALSE
29	GTEx	Nerve Tibial	CABLES2	0.30	0.15	enet	52	0.22	2.4e-15	-3.6	6.0	2.1e-09	0.05	1.00	0.00	FALSE
30	GTEx	Pituitary	STMN3	0.43	0.00	enet	8	0.06	1.1e-02	-2.2	-6.4	2.0e-10	0.63	0.03	0.64	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	CABLES2	0.16	0.07	lasso	7	0.10	2.5e-06	-3.6	5.5	4.6e-08	0.05	0.83	0.01	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CABLES2	0.18	0.17	enet	13	0.16	3.4e-13	-3.8	5.3	1.2e-07	0.04	1.00	0.00	FALSE
33	GTEx	Testis	RTEL1	0.19	0.06	lasso	5	0.14	8.0e-07	-7.1	-5.3	9.3e-08	0.80	0.01	0.98	FALSE
34	GTEx	Thyroid	SLC2A4RG	0.12	0.06	lasso	5	0.04	2.4e-04	-7.2	6.9	6.1e-12	-0.83	0.14	0.82	FALSE
35	GTEx	Vagina	CABLES2	0.49	0.04	lasso	6	0.02	1.4e-01	6.3	6.1	8.3e-10	0.09	0.06	0.05	FALSE
36	GTEx	Whole Blood	STMN3	0.10	0.00	lasso	3	0.00	1.2e-01	-7.3	7.7	1.2e-14	-0.76	0.03	0.69	FALSE
37	METSIM	Adipose	STMN3	0.20	0.08	enet	30	0.11	1.0e-16	-6.1	6.4	1.6e-10	-0.56	0.99	0.01	FALSE
38	METSIM	Adipose	TPD52L2	0.03	0.00	bslmm	207	0.02	1.5e-03	4.4	7.9	2.6e-15	-0.46	0.04	0.41	FALSE
39	YFS	Blood	LIME1	0.12	0.19	enet	15	0.19	5.3e-59	-7.6	-7.1	9.4e-13	0.67	0.60	0.40	FALSE
40	The Cancer Genome Atlas	Esophageal Carcinoma	GMEB2	0.16	0.04	blup	64	0.05	1.0e-02	2.5	5.6	1.8e-08	-0.45	0.02	0.20	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STMN3	0.02	0.02	blup	43	0.02	1.7e-03	-7.4	-8.0	1.7e-15	0.92	0.01	0.89	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TNFRSF6B	0.03	0.01	blup	44	0.02	7.1e-04	-7.3	-7.6	2.8e-14	0.89	0.02	0.91	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC2A4RG	0.03	0.01	blup	48	0.02	2.4e-03	-7.3	7.6	2.2e-14	-0.80	0.05	0.56	FALSE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LIME1	0.08	0.07	lasso	4	0.06	2.0e-04	-6.0	7.0	2.4e-12	-0.67	0.05	0.82	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIME1	0.02	0.03	blup	47	0.02	6.2e-03	-7.1	-8.2	2.1e-16	0.85	0.02	0.81	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	TNFRSF6B	0.02	0.01	enet	7	0.01	6.9e-03	-7.2	-8.1	8.3e-16	0.84	0.10	0.32	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RTEL1	0.05	0.04	blup	56	0.03	4.2e-03	-5.7	-7.7	1.0e-14	0.77	0.03	0.40	FALSE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STMN3	0.07	0.01	blup	41	0.05	4.2e-04	-8.1	-8.3	9.8e-17	0.87	0.01	0.95	TRUE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TNFRSF6B	0.05	0.02	blup	44	0.03	2.9e-03	-7.8	-7.2	7.3e-13	0.64	0.02	0.17	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARFRP1	0.03	0.02	lasso	2	0.02	1.2e-03	-7.9	7.9	3.7e-15	-0.70	0.12	0.49	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	LIME1	0.04	0.05	blup	47	0.05	9.0e-06	-7.6	-7.8	7.0e-15	0.72	0.19	0.80	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC2A4RG	0.05	0.01	blup	48	0.02	2.0e-03	-7.7	8.8	1.0e-18	-0.67	0.01	0.94	TRUE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZGPAT	0.05	0.06	lasso	3	0.06	5.5e-07	-7.4	7.7	1.1e-14	-0.88	0.43	0.57	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LIME1	0.10	0.02	blup	47	0.04	1.5e-02	-7.7	-7.2	8.2e-13	0.78	0.01	0.54	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS21	0.15	0.01	blup	59	0.02	4.9e-02	5.0	-5.9	4.1e-09	-0.08	0.01	0.58	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	ARFRP1	0.04	0.00	blup	51	0.00	1.3e-01	-7.6	7.1	9.2e-13	-0.66	0.03	0.13	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	LIME1	0.05	0.03	blup	47	0.04	3.9e-05	-7.2	-6.2	4.0e-10	0.78	0.08	0.90	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	ZGPAT	0.05	0.04	blup	60	0.03	2.3e-04	-7.2	6.1	1.3e-09	-0.84	0.08	0.90	FALSE