TWAS hub - SLMO2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0280	0.00480	0.022	0.012	0.016	0.021	0.018	8.1e-04	0.0120	3.9e-03	0.0013	2.4e-03
2	GTEx	Cells Transformed fibroblasts	0.1570	0.0460	0.00021	0.127	NA	0.094	NA	0.113	9.5e-10	NA	1.6e-07	NA	8.3e-09
3	TCGA	Cervical Squamous Cell Carcinoma	0.0650	0.0390	0.00450	0.037	0.034	0.011	NA	0.004	6.2e-03	0.0088	8.4e-02	NA	1.9e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0272	0.0151	0.00210	0.002	0.010	0.008	NA	0.003	1.7e-01	0.0260	4.1e-02	NA	1.3e-01
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0450	0.0270	0.00910	0.017	0.024	0.015	NA	0.014	3.6e-02	0.0160	4.4e-02	NA	5.0e-02
6	TCGA	Lung Adenocarcinoma	0.0253	0.0145	0.00690	0.004	0.009	0.002	NA	0.002	1.1e-01	0.0300	1.5e-01	NA	1.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	12.9	149.3	309.8	-17.6	11.0	6.1	0.6	-12.2	16.7
Medication: Ibuprofen	5.3	6.3	10.0	-0.5	-3.1	-2.9	-3.2	-1.5	-2.7
Qualifications: O levels/GCSEs or equivalent	4.5	7.2	13.0	-0.7	-2.7	-3.6	-3.2	-2.5	-2.5
Blood clot in the leg (DVT)	3.8	4.9	9.6	-2.1	2.5	2.4	1.8	-0.2	3.1
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.6	8.1	-0.8	-2.4	-2.5	-2.8	-1.7	-1.9
Mouth/teeth dental problems	3.5	5.3	7.8	-1.7	-2.4	-2.6	-2.7	-2.8	-1.4
Osteoporosis (self-reported)	3.4	4.2	7.3	-0.6	-2.0	-2.7	-2.7	-1.6	-2.0
Coronary Artery Disease (CAD)	3.2	3.8	5.3	0.7	2.2	2.3	2.3	1.6	2.0
Qualifications: CSEs or equivalent	3.2	4.2	7.0	1.9	1.3	2.6	2.3	2.5	1.2
Eye problems/disorders: Glaucoma	3.2	3.8	5.5	-1.1	-2.2	-2.1	-2.3	-2.2	-1.4
Age started oral contraceptive pill	3.2	4.0	6.3	-1.9	-1.5	-2.4	-2.4	-2.5	-1.0
Deep venous thrombosis (DVT) (self-reported)	3.1	4.0	7.7	-1.6	2.2	2.3	1.8	0.2	2.8
Medication: Cholesterol lowering	2.8	4.4	11.6	3.0	1.0	1.3	1.6	3.4	-0.1
Serious illness, injury or assault to yourself	2.7	3.2	5.8	-2.0	-1.1	-1.6	-2.3	-2.4	-0.8
High blood pressure	2.5	6.9	17.8	4.1	-0.4	-0.6	-0.1	4.2	-2.5
Suffer from ‘nerves’	2.5	4.0	7.2	2.7	2.5	1.6	1.3	2.1	1.4
Hypertension (Self-reported)	2.5	7.1	17.2	4.1	-0.7	-0.9	-0.6	4.0	-2.8
Ever smoked	2.5	4.4	6.1	1.7	2.3	2.1	2.2	2.5	1.6
Hair/balding pattern: Pattern 3	2.4	3.6	8.6	2.4	0.9	1.8	1.8	2.9	0.5
Qualifications: A levels/AS levels or equivalent	2.4	5.3	9.0	0.4	-2.5	-3.0	-2.8	-1.6	-2.4
Supplements: Zinc	2.3	2.5	4.3	1.3	0.8	2.1	2.0	1.8	1.0
Past tobacco smoking	2.3	4.3	6.9	-1.9	-2.0	-2.1	-2.3	-2.6	-1.3
Qualifications: None of the above	2.3	4.9	8.1	0.3	2.2	2.8	2.6	2.0	2.3
Mouth/teeth dental problems: Dentures	2.3	3.8	5.5	0.5	2.3	2.2	2.3	1.9	1.9
Vascular/heart problems diagnosed by doctor	2.3	6.1	16.1	-3.9	0.4	0.4	-0.1	-4.0	2.2
Pain experienced in last month	2.3	3.9	7.2	-0.7	-2.0	-2.1	-2.7	-1.8	-2.0
Fluid intelligence score	2.2	4.6	8.2	0.7	-2.4	-2.9	-2.2	-1.0	-2.7
Medication: Blood pressure	2.2	3.9	10.6	3.3	-1.1	-0.4	-0.4	2.6	-2.1
Number of full sisters	2.2	2.6	4.6	0.7	2.0	2.1	1.5	1.1	1.8
Back pain experienced in last month	2.2	3.2	8.0	0.0	2.7	1.5	1.2	0.6	2.8
Alzheimer’s Disease (in mother)	2.1	2.4	5.1	-0.5	-1.6	-2.3	-1.8	-1.4	-1.3
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	3.8	-0.3	-1.8	-1.9	-1.3	-1.0	-2.0
Medication: Atenolol	2.1	2.7	5.9	2.4	-1.5	-1.0	-1.3	1.2	-1.9
Falls in the last year	2.1	2.8	6.0	-1.9	1.7	0.5	-0.2	-2.0	2.4
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	9.6	-2.9	-0.4	-0.7	-0.8	-3.1	0.9
Qualifications: College or University degree	2.0	6.4	10.5	-0.7	-3.0	-2.8	-3.2	-1.9	-2.6
Intelligence (Savage-Jansen 2018)	1.9	5.7	10.4	-1.3	-2.6	-3.2	-2.2	-2.5	-2.1
Primary Biliary Cirrhosis	1.9	2.7	4.5	-1.6	1.9	1.9	1.4	-0.5	2.1
Chronotype (morning person)	1.9	4.3	9.8	3.1	0.8	1.4	2.1	3.0	0.1
Sensitivity / hurt feelings	1.9	3.3	5.0	2.2	1.9	1.3	1.9	2.2	0.9
Sitting height	1.9	13.3	21.8	2.6	4.7	3.7	3.5	3.9	3.2
Arm predicted mass (right)	1.9	9.8	16.2	2.0	2.7	4.0	3.5	3.1	3.1
Trunk fat-free mass	1.8	10.3	17.0	1.8	3.0	4.1	3.5	3.1	3.3
Trunk predicted mass	1.8	10.1	16.9	1.7	3.0	4.1	3.4	3.0	3.3
Average weekly champagne plus white wine intake	1.8	2.4	4.3	-0.2	2.1	1.7	1.7	1.3	1.7
Average weekly beer plus cider intake	1.8	2.7	6.2	-1.4	1.7	1.7	1.3	-0.7	2.5
Arm predicted mass (left)	1.8	9.0	15.0	2.0	2.6	3.9	3.2	3.0	3.0
Systolic Blood Pressure	1.7	8.3	16.6	4.1	-1.3	-1.5	-1.3	3.9	-3.6
Smoking Status	1.7	4.0	6.7	0.7	2.6	2.2	2.3	1.5	2.2
Severe depression (siblings)	1.7	1.9	3.9	1.0	-2.0	-1.4	-0.7	0.4	-2.0
Townsend deprivation index at recruitment	1.7	2.3	4.8	-1.6	2.2	1.3	0.8	-0.7	2.0
Current tobacco smoking	1.7	2.9	6.0	-1.3	2.4	1.5	1.3	-0.4	2.4
Medication: Levothyroxine sodium	1.7	2.9	5.1	1.6	-2.2	-1.6	-1.5	0.2	-2.2
Trunk fat mass	1.7	7.2	10.7	1.6	2.2	3.3	3.2	3.0	2.3
Standing height	1.7	17.4	28.3	3.1	5.3	4.1	3.8	4.4	4.0
Arm fat-free mass (right)	1.7	8.9	15.1	1.8	2.6	3.9	3.3	2.8	3.1
High cholesterol (Self-reported)	1.7	3.0	6.2	2.5	-1.0	-0.7	-0.4	2.4	-2.0
Leg fat percentage (left)	1.7	6.0	10.5	2.4	1.0	2.8	3.2	3.2	1.1
Alcohol drinker status: Previous	1.7	1.9	5.2	2.3	-1.0	-0.1	0.1	1.6	-1.7
Triglycerides	1.6	2.7	4.2	-0.9	-2.0	-1.9	-1.7	-1.3	-1.7
Cardiovascular Disease	1.6	5.3	14.6	3.4	-0.2	-0.7	-0.2	3.8	-2.3
Type 2 Diabetes (T2D) (2018)	1.6	3.0	5.3	0.7	1.8	2.3	1.9	1.5	1.8
Hand grip strength (right)	1.6	4.4	7.6	2.4	1.6	2.1	2.2	2.8	1.1
Weight	1.6	7.9	13.6	1.4	2.5	3.7	3.2	2.7	2.9
Pulse wave reflection index	1.6	1.9	4.1	0.4	2.0	1.4	1.2	1.4	1.4
Leg fat percentage (right)	1.6	6.0	10.4	2.2	1.2	2.7	3.2	3.2	1.2
Eye problems/disorders: None of the above	1.6	1.8	2.7	0.5	1.6	1.4	1.7	1.2	1.4
Leg fat mass (right)	1.6	6.3	10.1	1.7	1.6	3.1	3.2	2.9	2.0
Illnesses of siblings: Diabetes	1.6	2.0	4.5	-2.1	1.3	0.7	0.3	-1.4	1.8
Whole body fat-free mass	1.6	9.1	16.1	1.3	2.9	4.0	3.2	2.5	3.5
Loneliness, isolation	1.6	2.1	5.4	0.1	2.3	1.2	1.4	0.8	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	5.1	1.8	0.7	0.7	1.1	2.3	0.1
Smoking status: Current	1.6	2.6	5.3	-0.8	2.2	1.6	1.4	0.1	2.3
Basal metabolic rate	1.6	8.8	15.3	1.3	2.9	3.9	3.1	2.5	3.4
Diastolic blood pressure, automated reading	1.6	4.9	8.7	2.9	-1.2	-1.2	-1.4	2.8	-2.8
Leg fat mass (left)	1.6	6.2	9.9	1.7	1.5	3.1	3.2	2.9	2.0
Height	1.5	28.4	44.1	3.8	6.6	5.3	5.0	5.7	5.2
Illnesses of siblings	1.5	2.1	5.2	0.0	-2.3	-1.6	-1.2	-0.9	-1.6
Leg pain on walking	1.5	1.9	2.8	-1.1	-1.6	-1.6	-1.3	-1.7	-0.5
Whole body water mass	1.5	8.4	15.1	1.3	2.8	3.9	3.0	2.4	3.3
Medication: Lisinopril	1.5	1.9	6.0	2.4	0.0	-0.0	0.5	1.9	-1.2
Arm fat-free mass (left)	1.5	7.6	12.5	1.7	2.3	3.5	3.0	2.7	2.8
Verbal and Numeric Reasoning (VNR)	1.4	3.4	7.5	-0.0	-1.9	-2.7	-1.8	-1.3	-2.2
Diabetes (self-reported)	1.4	2.2	3.5	1.2	1.5	1.7	1.5	1.9	1.0
Depression (self-reported)	1.4	1.7	2.9	-0.3	1.5	1.6	1.6	0.3	1.7
Whole body fat mass	1.4	6.0	9.2	1.5	1.9	3.0	2.9	2.8	2.2
Ulcerative Colitis (UC)	1.3	2.4	5.0	1.2	0.3	1.9	2.0	2.2	-0.6
HbA1C	1.3	1.4	4.3	0.0	0.3	2.1	1.5	0.7	1.2
HDL Cholesterol	1.3	2.1	3.9	-0.0	1.8	2.0	1.3	0.7	1.8
Lupus	1.3	1.9	6.1	2.5	0.3	0.4	1.1	1.9	-0.7
Ulcerative Colitis	1.3	2.0	4.3	0.4	0.7	2.1	1.8	1.9	0.1
Systolic blood pressure, automated reading	1.3	3.8	7.5	2.6	-1.1	-1.0	-0.8	2.7	-2.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	4.2	2.1	-0.7	0.1	0.3	1.6	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	6.3	1.9	0.4	0.8	1.2	2.5	-0.8
Medication: Gliclazide	1.3	1.5	2.8	1.1	0.9	1.1	1.7	1.7	0.2
Supplements: Calcium	1.3	1.4	3.4	-0.0	-0.7	-1.3	-1.8	-1.5	-0.8
Leg fat-free mass (left)	1.2	6.3	11.2	0.4	2.6	3.4	2.4	1.5	3.3
Leg predicted mass (left)	1.2	6.1	10.9	0.4	2.6	3.3	2.4	1.5	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	8.1	-1.3	2.7	1.7	1.8	0.1	2.8
Worry too long after embarrassment	1.2	2.0	3.5	1.6	-1.8	-1.4	-1.0	0.2	-1.9
Number of self-reported non-cancer illnesses	1.2	2.1	6.9	2.6	0.3	0.3	0.2	2.2	-0.4
Bipolar Disorder (2018)	1.1	1.7	4.2	1.9	-0.3	0.1	1.0	2.1	-1.1
Depression (Nagel 2018)	1.1	1.7	4.3	-2.1	0.3	0.2	-0.4	-1.9	1.4
Mean Putamen Volume	1.1	1.3	2.5	-1.3	-0.7	-1.1	-1.6	-1.2	-0.5
Medication: Metformin	1.1	1.6	3.2	1.6	1.1	1.1	1.1	1.8	0.3
Trunk fat percentage	1.1	4.4	6.6	1.4	1.6	2.5	2.6	2.5	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.3	-1.8	0.7	-0.1	-0.5	-1.7	1.5
Forced vital capacity (FVC)	1.1	4.1	8.1	-1.2	2.7	2.0	1.8	0.1	2.8
Financial difficulties in last 2 years	1.1	1.4	2.5	0.9	0.9	1.6	1.4	1.1	1.2
Hip circumference	1.1	4.6	8.8	0.2	1.9	3.0	2.4	1.4	2.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.1	2.0	-0.8	0.1	0.1	1.5	-1.1
Body fat percentage	1.1	4.5	7.3	1.5	1.4	2.5	2.7	2.6	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.8	2.0	-0.1	0.2	0.5	1.8	-0.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.6	0.3	-0.8	-1.5	-1.0	-0.2	-1.9
Mean time to correctly identify matches	1.1	2.1	2.6	-1.3	-1.5	-1.6	-1.6	-1.4	-1.3
Smoking status: Previous	1.1	1.7	3.4	1.7	0.9	1.2	1.4	1.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.4	0.7	2.1	1.7	1.5	1.2	1.5
Leg fat-free mass (right)	1.1	5.7	11.0	0.4	2.4	3.3	2.2	1.3	3.3
Osteoarthritis (self-reported)	1.1	1.5	3.5	-1.4	0.6	1.2	0.7	-1.0	1.9
Leg predicted mass (right)	1.1	5.8	11.3	0.3	2.4	3.3	2.2	1.3	3.4
Schizophrenia vs Biploar Disorder	1.0	1.3	2.2	-1.0	-0.8	-1.0	-1.4	-1.5	-0.8
Crohns Disease (2012)	1.0	1.6	4.8	-0.0	-1.2	-1.4	-1.1	-0.2	-2.2
Average weekly spirits intake	1.0	1.3	2.3	0.7	0.8	1.5	1.3	0.5	1.5
Waist circumference	1.0	3.5	5.7	1.6	0.8	2.4	2.2	2.4	1.2
Worrier / anxious feelings	1.0	1.8	3.5	0.6	-1.0	-1.9	-1.9	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	6.8	-1.2	2.5	1.7	1.6	-0.1	2.6
Forced vital capacity (FVC), Best measure	1.0	3.6	7.7	-0.6	2.8	1.8	1.8	0.7	2.6
Comparative body size at age 10	1.0	2.6	4.8	-1.3	-2.2	-1.7	-1.2	-1.5	-1.7
Number of full brothers	1.0	1.2	2.8	-0.9	1.4	1.1	0.8	-0.1	1.7
Pulse rate, automated reading	1.0	3.1	6.3	-1.7	-1.5	-1.6	-2.0	-2.5	-0.7
Illnesses of father: None of the above (group 1)	1.0	1.3	3.0	-1.7	-1.1	-1.0	-0.9	-1.2	-0.4
Guilty feelings	1.0	1.4	2.1	-0.6	-1.2	-1.4	-1.4	-1.5	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.4	0.1	-1.2	-1.6	-1.2	-0.5	-1.5
LDL Cholesterol	0.9	1.5	2.3	-0.2	1.4	1.5	1.4	0.5	1.5
Heel T-Score	0.9	7.0	13.0	-3.3	2.4	2.4	1.9	-1.7	3.6
Time employed in main current job	0.9	1.1	1.8	0.4	-1.1	-1.2	-1.3	-1.0	-0.9
Pulse rate	0.9	1.5	3.5	-1.5	-0.4	-0.9	-1.4	-1.9	0.0
Length of working week for main job	0.9	1.0	2.0	-1.2	1.0	0.5	0.9	-0.7	1.4
Birth weight of first child	0.9	1.7	3.1	0.7	0.9	1.8	1.7	1.4	0.8
Glaucoma (self-reported)	0.9	1.1	2.2	-0.6	-1.5	-1.0	-0.9	-1.2	-0.7
Wheeze or whistling in the chest in last year	0.9	1.5	2.8	0.4	1.7	1.4	1.5	0.9	1.2
Angina (self-reported)	0.9	1.2	3.1	0.7	-0.7	-1.8	-0.9	0.2	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.4	-0.6	-1.0	-1.6	-0.4	-0.5	-1.6
Supplements: Vitamin C	0.9	1.1	1.9	0.9	0.5	1.4	1.2	1.2	0.9
Illnesses of father: Heart disease	0.9	1.3	2.5	0.6	1.6	1.0	1.5	0.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.7	-1.5	1.3	1.1	1.3	-0.5	1.9
Crohns Disease (2017)	0.8	1.9	5.1	-0.3	-1.6	-1.5	-1.1	-0.2	-2.3
Reaction Time	0.8	1.5	2.2	-0.9	-1.3	-1.5	-1.3	-1.2	-1.2
Fasting Glucose	0.8	1.0	1.9	-0.0	0.6	1.4	1.3	0.5	1.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.9	1.7	-0.0	0.7	0.5	1.2	-0.3
Blood Red Count	0.8	8.1	16.2	3.6	-3.2	-1.3	-0.7	2.6	-4.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.5	-1.4	0.8	0.4	0.0	-1.2	1.6
Angina	0.8	1.0	2.7	0.7	-0.6	-1.6	-0.8	0.2	-1.4
Diabetes (mother)	0.8	1.0	2.4	-0.3	0.9	1.6	1.2	0.4	1.0
Impedance of leg (right)	0.8	3.7	9.1	3.0	1.3	0.1	1.4	3.0	-0.7
Impedance of leg (left)	0.8	3.8	10.6	3.2	1.0	0.2	1.2	3.1	-0.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.7	-1.5	0.4	0.2	-0.3	-1.6	1.1
Number of live births	0.8	1.1	2.3	0.6	0.4	1.1	1.5	1.4	0.6
Pulse wave Arterial Stiffness index	0.8	0.9	2.6	-0.7	1.6	0.7	0.4	0.4	1.2
Tense / ‘highly strung’	0.8	1.3	2.5	0.3	1.6	1.1	1.2	1.2	0.9
Hair/balding pattern: Pattern 4	0.8	2.0	3.9	1.3	-1.7	-1.2	-1.4	0.2	-2.0
Neck or shoulder pain in last month	0.8	1.2	2.1	0.2	1.2	1.2	1.5	0.4	1.4
Comparative height size at age 10	0.8	4.5	6.3	0.6	2.4	2.2	2.2	2.2	2.5
Knee pain experienced in last month	0.8	1.3	2.6	-0.8	0.8	1.5	1.6	0.7	1.2
Friendships satisfaction	0.8	1.0	2.3	-1.3	0.7	-0.1	-0.8	-1.5	0.8
Qualifications: nursing, teaching	0.8	1.2	2.6	-0.6	-0.1	-1.4	-1.4	-1.6	-0.3
Eye problems/disorders: Cataract	0.8	0.9	2.6	-1.6	0.5	-0.1	-0.4	-1.5	0.4
Respiratory disease	0.7	1.5	3.6	0.1	-1.9	-1.2	-1.1	-0.2	-1.6
Medication: Co-codamol	0.7	0.8	1.7	-0.4	-0.7	-1.3	-1.2	-0.7	-0.9
Stomach or abdominal pain in last month	0.7	0.9	1.8	-1.2	0.4	1.0	0.9	-0.3	1.3
Alcohol usually taken with meals	0.7	1.1	2.7	1.6	0.8	0.9	1.0	0.9	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.7	-0.6	1.4	1.0	0.5	-0.2	1.7
Hair/balding pattern: Pattern 2	0.7	0.9	2.3	-0.6	-0.1	-1.5	-0.9	-1.0	-0.8
Medication: Simvastatin	0.7	1.1	4.0	1.3	0.0	0.1	0.2	2.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.6	-1.4	0.0	-0.8	-0.6	-1.6	0.4
Arm fat mass (left)	0.7	2.8	5.5	0.4	1.2	2.3	2.1	1.4	1.8
Ever taken oral contraceptive pill	0.7	0.8	1.5	0.8	0.7	1.0	1.2	0.9	0.6
Illnesses of father: High blood pressure	0.7	0.9	3.7	1.9	0.2	-0.4	-0.3	1.0	-0.6
Risk taking	0.7	1.0	1.6	-1.3	1.2	0.9	1.1	-0.3	1.1
Heart disease (siblings)	0.7	0.8	1.8	-1.2	1.1	0.5	0.4	-0.5	1.4
Pack years of smoking	0.7	1.0	2.4	-0.6	0.7	1.3	1.0	-0.1	1.6
Neuroticism (Nagel 2018)	0.6	1.3	4.5	2.1	0.3	0.1	0.4	1.7	-0.6
Ovarian Cancer	0.6	0.9	2.3	-1.0	0.9	0.4	0.1	-0.9	1.5
Age at First Birth	0.6	0.8	1.8	-0.8	-0.9	-0.7	-1.3	-1.0	-0.5
Blood White Count	0.6	4.3	8.6	1.6	0.9	2.5	2.9	2.6	0.8
BMI	0.6	3.7	8.5	0.8	0.7	2.9	2.4	2.0	1.6
Number of treatments/medications taken	0.6	1.0	2.4	0.4	-1.0	-1.1	-0.9	0.6	-1.5
Relative age of first facial hair	0.6	1.2	2.3	0.9	-1.5	-1.0	-1.3	-0.2	-1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.1	0.9	1.0	0.5	1.0	1.0	0.7
Medication for hormone replacement therapy	0.6	0.6	1.7	1.3	0.0	-0.0	0.8	1.2	-0.4
Taking other prescription medications	0.6	0.9	2.1	-0.1	-0.8	-1.5	-1.1	-0.7	-0.8
Age when periods started (menarche)	0.6	1.4	2.6	0.6	1.6	1.2	1.1	1.1	1.2
Supplements: Glucosamine	0.6	0.7	1.5	0.7	0.4	0.9	1.2	1.2	0.4
Illnesses of mother	0.6	0.7	1.5	-1.2	-0.7	-0.6	-0.7	-1.2	-0.4
Arm fat mass (right)	0.6	2.6	5.1	0.3	1.2	2.3	1.9	1.3	1.8
Age at first live birth	0.6	1.1	2.5	-0.5	-0.9	-1.1	-1.6	-0.9	-1.1
Pulse wave peak to peak time	0.6	0.7	1.7	1.0	-1.3	-0.5	-0.2	-0.2	-1.0
Migraine (self-reported)	0.6	0.7	2.4	1.6	0.0	0.5	0.2	1.2	-0.2
Heart disease (mother)	0.6	0.7	1.6	0.2	1.2	1.1	0.3	0.2	1.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.6	1.3	0.3	1.0	0.5	0.5	1.1
Diabetes diagnosed by doctor	0.6	1.0	1.5	0.9	1.1	1.1	0.9	1.2	0.6
Wears glasses or contact lenses	0.6	0.6	1.5	0.9	-0.9	-0.1	-0.4	0.7	-1.2
Unable to work because of sickness or disability	0.6	0.8	2.3	-1.5	0.2	-0.5	-0.9	-1.2	0.2
Depressed Affect (Nagel 2018)	0.5	1.1	3.5	1.9	-0.1	-0.0	0.3	1.6	-0.5
Worry (Nagel 2018)	0.5	1.0	3.4	1.9	0.3	0.1	0.2	1.4	-0.6
Rheumatoid Arthritis	0.5	0.6	2.0	-1.4	0.1	-0.2	-0.6	-1.1	0.3
Waist Hip Ratio (WHR)	0.5	2.5	6.1	2.5	-0.9	-0.2	-0.0	2.3	-1.6
Hypothyroidism (self reported)	0.5	1.1	2.1	0.9	-1.4	-1.2	-0.9	-0.3	-1.2
Hand grip strength (left)	0.5	1.4	1.8	0.7	1.3	1.3	1.3	1.3	1.1
Pack years adult smoking proportion	0.5	0.8	2.2	-0.6	0.7	1.0	0.7	-0.2	1.5
High blood pressure (mother)	0.5	0.8	2.3	1.5	0.1	-0.2	-0.2	1.4	-0.5
Nervous feelings	0.5	1.0	3.6	1.9	0.1	0.3	0.1	1.3	-0.7
Heart attack	0.5	0.6	1.7	-0.5	1.0	-0.1	-0.1	-0.8	1.3
Prospective memory result	0.5	0.6	1.5	-1.2	0.6	0.5	0.6	-0.4	1.0
Loud music exposure frequency	0.5	0.5	1.6	-0.1	0.6	0.9	0.2	-0.5	1.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.7	1.2	-1.3	-0.9	-0.9	0.2	-1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-0.9	0.2	1.2	0.4	-0.2	1.0
High blood pressure (siblings)	0.5	0.7	1.6	1.1	1.0	0.6	0.2	1.3	0.0
Number of children fathered	0.5	0.6	1.1	0.5	0.9	0.7	1.0	0.7	0.6
Alcohol intake frequency.	0.5	1.2	2.4	0.3	-1.1	-1.3	-1.3	-0.5	-1.6
Average weekly red wine intake	0.5	0.7	1.6	0.8	-0.4	-1.3	-0.5	-0.0	-1.1
Mother’s age at death	0.5	0.6	1.1	0.9	-0.8	-0.8	-0.5	0.2	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	-0.4	0.8	1.2	0.6	0.7	0.7
Alzheimer’s Disease (in father)	0.4	0.4	1.2	0.7	0.2	0.6	0.7	1.1	-0.2
Irritable Bowel Disease (IBD)	0.4	1.1	2.4	0.7	-0.5	0.4	0.8	1.5	-1.6
Major Depression (MDD)	0.4	0.5	1.1	1.0	-0.8	-0.5	-0.1	0.3	-0.9
Breast Cancer	0.4	0.8	1.6	-1.3	0.9	0.4	-0.2	-1.1	1.1
Body mass index (BMI)	0.4	1.5	4.1	0.0	0.2	2.0	1.7	0.9	1.2
Arm fat percentage (right)	0.4	1.6	3.5	0.3	0.7	1.9	1.7	1.2	1.2
Peak expiratory flow (PEF)	0.4	0.8	1.8	-0.5	1.3	0.9	0.7	0.1	1.3
Emphysema/chronic bronchitis	0.4	0.5	1.4	1.2	0.3	0.4	0.5	0.9	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	-0.1	-1.3	-0.4	-0.6	-0.3	-0.8
Family relationship satisfaction	0.4	0.5	1.3	-0.9	1.1	0.3	0.2	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.0	-1.0	-0.4	-0.5	-0.6	-0.9	-0.1
Arm fat percentage (left)	0.4	1.8	3.7	0.2	0.7	1.9	1.8	1.1	1.3
Medication: Blood pressure	0.4	0.7	1.8	0.8	0.4	-0.7	-0.9	1.4	-0.7
Medication: Bendroflumethiazide	0.4	0.6	1.6	1.0	-0.1	-0.4	-0.4	1.3	-0.7
Number of operations (self-reported)	0.4	0.6	1.3	1.1	0.8	0.4	0.7	1.0	0.3
Irritability	0.4	0.7	1.3	-1.0	0.0	-0.9	-1.1	-1.1	0.0
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	-0.1	-0.9	-0.9	-0.3	-0.3	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-0.7	0.7	-0.3	-0.4	-0.9	1.0
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	0.7	-0.7	-0.6	0.3	0.9	-1.5
Prostate Cancer	0.3	0.4	0.9	-0.1	0.7	0.7	1.0	0.5	0.6
Body Mass Index (BMI) (2010)	0.3	0.5	1.2	0.1	0.2	1.1	0.9	0.7	0.5
Neuroticism (2016)	0.3	0.4	0.9	-0.9	0.8	0.5	-0.0	-0.2	0.7
Blood Eosinophil Count	0.3	2.6	7.1	2.4	0.4	0.9	1.4	2.7	-0.3
Neuroticism	0.3	0.8	3.0	1.7	0.0	-0.3	-0.2	1.2	-0.4
Diabetes (father)	0.3	0.3	0.6	0.7	0.3	0.8	-0.4	-0.1	0.8
Multivitamins +/- minerals	0.3	0.4	0.8	-0.3	-0.6	-0.7	-0.9	-0.7	-0.1
Number of incorrect matches in round	0.3	0.4	1.9	-1.4	-0.2	0.4	0.5	-0.4	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.0	0.1	0.3	1.4	1.1	0.4	0.9
Medication: Ramipril	0.3	0.4	1.3	1.2	0.3	-0.5	-0.2	0.7	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	0.7	0.5	0.8	0.8	0.2	0.6	0.8
Asthma	0.3	0.6	1.5	0.4	-0.8	-0.8	-0.8	-0.2	-1.2
Lung cancer (father)	0.3	0.4	1.3	-0.0	-1.1	-0.6	-0.5	-0.4	-0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.1	0.7	0.6	0.7	0.2	0.8
Gout (self-reported)	0.3	0.4	0.9	-0.3	0.6	0.7	0.9	0.3	0.8
Medication: Amlodipine	0.3	0.4	0.9	0.2	0.7	0.8	0.5	0.9	0.3
Health satisfaction	0.3	0.4	0.7	-0.8	0.6	-0.8	-0.6	-0.6	0.5
Long-standing illness, disability or infirmity	0.3	0.5	1.2	0.8	-0.5	-0.7	-1.1	0.2	-0.8
Commuting to job workplace: Walk	0.3	0.3	0.9	-1.0	0.9	-0.0	0.1	-0.4	0.5
Medication for cholesterol	0.3	0.5	1.8	-0.8	-0.6	0.1	-0.2	-1.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	0.7	1.0	0.4	0.4	0.4	0.7
Breast cancer (self-reported)	0.3	0.3	1.5	-1.2	0.2	0.2	0.0	-0.5	-0.1
Asthma (self-reported)	0.3	0.6	1.7	0.9	-0.8	-0.7	-0.4	0.3	-1.3
Fractured/broken bones in last 5 years	0.3	0.4	1.3	-1.1	0.1	0.0	-0.0	-0.9	0.2
Schizophrenia (2018)	0.2	0.5	1.0	-0.6	-0.7	-0.8	-0.3	-0.5	-1.0
Schizophrenia (2014)	0.2	0.5	1.9	-0.0	-0.6	-0.7	-0.2	0.0	-1.4
Lung FVC	0.2	0.8	3.0	-1.7	0.4	0.3	0.5	-0.8	0.9
Average weekly fortified wine intake	0.2	0.2	0.4	-0.6	0.1	0.2	-0.1	-0.7	0.6
Maternal smoking around birth	0.2	0.3	0.8	-0.7	-0.4	0.3	-0.4	-0.9	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.5	0.5	0.1	-0.5	-0.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.3	0.2	0.0	1.1	1.0	0.4	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.1	0.6	0.6	0.4	0.1	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.8	-0.7	0.4	-0.2	-0.4	-0.9	0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.0	0.9	0.6	0.5	0.3	0.7
Had menopause	0.2	0.2	0.5	-0.5	0.4	-0.7	-0.1	-0.6	0.3
Allergy	0.2	0.4	0.9	0.4	-1.0	-0.2	0.1	0.5	-0.8
Pain all over the body in last month	0.2	0.2	0.3	-0.5	-0.5	-0.3	-0.6	-0.5	-0.4
Neuroticism score	0.2	0.4	1.5	1.2	0.3	0.1	0.2	0.8	-0.1
Impedance of arm (right)	0.2	0.8	2.4	-0.5	0.8	-1.5	-1.0	-0.7	-0.4
Noisy workplace	0.2	0.2	0.3	-0.3	0.2	0.4	0.5	-0.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.2	0.6	0.7	0.0	0.2	0.7
Medication: Lansoprazole	0.2	0.3	0.8	-0.3	0.4	-0.2	-0.9	-0.6	-0.0
Exposure to tobacco smoke at home	0.2	0.3	0.6	-0.5	-0.4	-0.8	-0.5	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.8	-0.2	-0.1	0.6	0.8	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.3	0.5	0.9	0.5	-0.1	0.6
Headache pain in last month	0.2	0.3	1.3	1.1	-0.3	-0.2	-0.0	0.5	-0.5
Birth weight	0.2	0.5	1.1	-0.3	0.6	0.9	0.6	0.1	1.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.2	0.5	0.7	0.8	0.3	0.3
Overall health rating	0.2	0.4	1.1	0.2	-0.3	-0.9	-1.1	0.1	-0.7
Medication: Aspirin	0.2	0.2	0.8	0.9	0.0	-0.2	-0.2	0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.7	-0.4	0.4	0.4	-0.1	-0.3	0.9
Ever had bowel cancer screening	0.2	0.2	0.7	-0.3	0.8	0.5	0.5	0.2	0.3
Mineral and other dietary supplements	0.2	0.2	0.6	0.5	0.3	0.4	0.4	0.8	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.0	1.0	0.2	0.1	0.5	0.6	-0.3
Medication: Atorvastatin	0.2	0.3	0.7	0.8	0.1	-0.0	-0.2	0.9	-0.5
Alcohol drinker status: Never	0.2	0.2	0.7	-0.4	-0.0	-0.8	0.1	-0.3	-0.4
Ever depressed for a whole week	0.2	0.3	0.5	-0.3	-0.3	-0.7	-0.7	-0.6	-0.2
Cholesterol lowering medication	0.2	0.3	0.7	0.3	-0.3	-0.4	-0.2	0.9	-0.6
Impedance of whole body	0.2	1.1	2.5	1.6	1.1	-0.8	0.2	1.4	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.4	0.2	-0.4	0.1	0.3	-0.2
Allergy or Eczema	0.1	0.3	0.6	-0.8	0.2	-0.1	0.2	-0.7	0.7
Lung FEV1/FVC ratio	0.1	0.8	1.5	-1.2	0.8	0.6	0.8	-0.5	1.0
Hair Pigment	0.1	1.7	4.9	1.8	0.8	1.2	0.4	2.2	-0.2
Tanning	0.1	0.6	1.3	-0.8	0.8	0.3	0.2	-0.9	1.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	0.6	-0.1	-0.1	0.0	0.7	-0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.1	0.4	-0.5	-0.4	-0.3	0.0
Vitamin and mineral supplements	0.1	0.1	0.3	-0.5	0.3	-0.1	-0.4	-0.3	0.0
Fed-up feelings	0.1	0.1	0.4	0.0	0.0	0.3	0.3	0.6	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	-0.6	-0.1	0.3	0.1	-0.4	0.4
Had other major operations	0.1	0.1	0.2	0.2	0.1	-0.3	-0.5	-0.3	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.0	0.1	-0.6	-0.4	-0.6	-0.2
Impedance of arm (left)	0.1	0.5	1.5	-0.1	1.0	-1.2	-0.6	-0.2	-0.3
Breastfed as a baby	0.1	0.1	0.4	-0.1	0.2	0.2	0.2	0.6	0.3
Medication: Paracetamol	0.1	0.2	0.6	0.1	0.1	0.7	0.8	0.4	-0.0
Shortness of breath walking on level ground	0.1	0.1	0.1	0.2	0.0	0.4	-0.3	0.4	0.2
Medication: Allopurinol	0.1	0.1	0.2	0.2	-0.4	-0.4	-0.2	-0.1	-0.0
Medication: Omeprazole	0.1	0.1	0.2	0.3	-0.4	-0.2	0.1	-0.1	0.4
Medication: Seretide 50 evohaler	0.1	0.2	0.5	0.7	0.2	0.1	0.3	0.6	0.1
Chest pain or discomfort	0.1	0.1	0.4	-0.1	-0.1	-0.6	-0.5	-0.1	-0.0
Age at last live birth	0.1	0.1	0.5	0.3	-0.3	-0.2	-0.1	0.3	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	0.2	-0.4	-0.4	0.2	0.0
Mood swings	0.1	0.2	0.6	0.8	0.3	0.2	0.7	0.4	0.3
Hearing aid user	0.1	0.1	0.2	-0.3	-0.4	0.3	0.2	0.1	-0.0
Commuting to job workplace: Public transport	0.1	0.2	0.5	-0.3	0.7	0.1	0.2	-0.5	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	0.2	-0.4	0.4	0.0	-0.5
Medication: Paracetamol	0.1	0.2	0.6	0.2	-0.5	0.3	0.3	0.3	-0.8
Commuting to job workplace: Cycle	0.1	0.2	0.3	-0.5	0.4	0.3	0.3	0.4	-0.3
Myopia	0.1	0.2	0.8	0.2	-0.1	-0.3	-0.9	0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.5	-0.0	0.0	0.1	0.3	-0.2	0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hearing difficulty/problems: Yes	0.0	0.1	0.3	-0.2	0.6	-0.1	0.2	-0.1	0.0
Relative age voice broke	0.0	0.1	0.2	0.5	0.3	0.1	-0.1	-0.1	0.2
Father’s age at death	0.0	0.0	0.1	-0.3	-0.0	0.1	0.2	-0.0	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.0	-0.1	0.2
Happiness	0.0	0.0	0.0	-0.1	-0.0	-0.2	-0.1	0.2	-0.2
Exposure to tobacco smoke outside home	0.0	0.0	0.1	-0.3	-0.2	0.1	0.2	-0.2	-0.1
Had major operations	0.0	0.0	0.1	0.0	0.3	0.2	0.1	0.1	0.0
Medication: Aspirin	0.0	0.1	0.2	0.5	0.2	-0.1	-0.1	0.2	-0.0
Miserableness	0.0	0.1	0.1	-0.2	0.3	-0.4	-0.4	-0.3	0.2
Financial situation satisfaction	0.0	0.1	0.2	-0.1	0.3	0.1	0.0	0.4	0.2

Hub : Genes

SLMO2

Models

Trait associations