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chr1:39,258,674-42,406,344

Best TWAS P=1.17e-31 · Best GWAS P=1.14e-34 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Esophagus Muscularis	MFSD2A	0.10	0.02	lasso	5	0.04	2.7e-03	12.28	11.7	1.2e-31	0.79	0.01	0.93	TRUE
56	The Cancer Genome Atlas	Thyroid Carcinoma	MFSD2A	0.08	0.02	enet	10	0.06	1.2e-06	-4.27	-9.9	6.0e-23	-0.74	0.01	0.98	TRUE
40	ROSMAP	Brain Pre-frontal Cortex	TRIT1	0.24	0.07	lasso	9	0.14	1.3e-17	-3.18	8.1	8.3e-16	0.54	0.98	0.02	TRUE
58	The Cancer Genome Atlas	Thyroid Carcinoma	SCMH1	0.07	0.08	blup	97	0.07	2.5e-07	-5.15	7.1	1.0e-12	-0.02	0.37	0.63	TRUE
9	GTEx	Brain Frontal Cortex BA9	PPIE	0.25	0.06	lasso	6	0.07	6.3e-03	2.84	7.0	2.8e-12	0.46	0.09	0.53	TRUE
28	GTEx	Nerve Tibial	PABPC4	0.17	0.08	enet	12	0.05	2.7e-04	3.64	-6.7	2.7e-11	-0.26	0.95	0.02	TRUE
34	GTEx	Testis	CAP1	0.12	0.07	enet	17	0.07	5.9e-04	5.38	-6.3	3.4e-10	-0.16	0.57	0.04	TRUE
13	GTEx	Breast Mammary Tissue (Male)	PPT1	0.19	0.10	lasso	2	0.06	1.8e-02	5.18	5.6	1.7e-08	0.13	0.06	0.06	TRUE
24	GTEx	Lung	TRIT1	0.15	0.11	enet	16	0.11	1.8e-08	-3.98	5.6	2.2e-08	0.34	0.99	0.00	TRUE
11	GTEx	Breast Mammary Tissue	PPT1	0.18	0.01	lasso	3	0.02	2.3e-02	5.18	5.6	2.3e-08	0.15	0.16	0.06	TRUE
7	GTEx	Brain Cerebellar Hemisphere	TRIT1	0.35	0.30	enet	6	0.28	8.4e-08	9.96	10.0	1.2e-23	0.80	0.33	0.57	FALSE
8	GTEx	Brain Frontal Cortex BA9	TRIT1	0.23	0.04	lasso	5	0.02	8.2e-02	-6.86	8.1	6.0e-16	0.53	0.05	0.29	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PPT1	0.08	0.00	blup	57	0.04	1.7e-02	6.51	7.3	3.9e-13	0.10	0.02	0.52	FALSE
27	GTEx	Nerve Tibial	SCMH1	0.16	0.03	enet	24	0.07	1.6e-05	-5.31	7.1	1.5e-12	-0.03	0.15	0.82	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	PPT1	0.06	0.03	blup	57	0.02	2.2e-02	6.39	7.0	3.6e-12	0.11	0.02	0.73	FALSE
21	GTEx	Esophagus Muscularis	PPT1	0.21	0.12	enet	14	0.14	4.6e-09	6.39	6.9	4.6e-12	0.09	1.00	0.00	FALSE
35	GTEx	Testis	PPT1	0.22	0.14	lasso	5	0.20	3.6e-09	4.96	6.9	5.8e-12	0.10	0.93	0.05	FALSE
33	GTEx	Stomach	TRIT1	0.30	0.02	lasso	4	0.08	1.5e-04	-3.81	6.7	1.6e-11	0.44	0.08	0.49	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	PPT1	0.15	0.10	enet	12	0.10	1.8e-04	5.18	6.6	3.9e-11	0.10	0.32	0.04	FALSE
36	GTEx	Thyroid	PPT1	0.10	0.08	lasso	5	0.09	1.3e-07	6.27	6.6	4.1e-11	0.09	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	PPT1	0.12	0.14	lasso	7	0.11	2.2e-08	6.14	6.6	4.5e-11	0.13	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Rectum Adenocarcinoma	PPT1	0.19	0.15	enet	10	0.12	9.3e-04	6.39	6.5	7.5e-11	0.08	0.02	0.87	FALSE
18	GTEx	Colon Transverse	MFSD2A	0.30	0.19	enet	11	0.21	2.7e-10	-6.44	-6.5	1.1e-10	-0.49	0.88	0.09	FALSE
4	GTEx	Adrenal Gland	PPT1	0.20	0.13	lasso	8	0.12	3.7e-05	6.14	6.4	1.2e-10	0.10	0.71	0.03	FALSE
10	GTEx	Brain Putamen basal ganglia	PPIE	0.26	0.27	enet	13	0.27	3.9e-07	2.86	6.4	1.3e-10	0.51	0.08	0.82	FALSE
31	GTEx	Ovary	PPT1	0.16	0.11	lasso	1	0.03	6.8e-02	6.40	6.4	1.5e-10	0.10	0.19	0.07	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CTPS1	0.12	-0.01	lasso	4	-0.01	7.5e-01	-6.50	-6.4	1.9e-10	0.00	0.02	0.46	FALSE
23	GTEx	Heart Atrial Appendage	PPT1	0.14	0.00	lasso	2	0.01	1.5e-01	6.39	6.3	2.1e-10	0.09	0.32	0.04	FALSE
2	GTEx	Adipose Subcutaneous	PPT1	0.08	0.07	lasso	3	0.05	3.5e-05	6.27	6.3	2.2e-10	0.12	0.98	0.00	FALSE
6	GTEx	Artery Tibial	PPT1	0.15	0.10	lasso	7	0.12	2.1e-09	6.40	6.3	2.4e-10	0.08	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPT1	0.12	0.04	enet	9	0.07	1.1e-08	6.15	6.3	3.1e-10	0.05	0.05	0.95	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	PPT1	0.07	0.07	lasso	3	0.07	1.4e-07	6.12	6.3	4.0e-10	0.12	0.11	0.89	FALSE
37	METSIM	Adipose	HEYL	0.05	0.00	bslmm	378	0.02	6.9e-04	1.70	-6.2	5.1e-10	-0.22	0.05	0.03	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPT1	0.04	0.08	lasso	3	0.07	1.5e-07	6.12	6.2	6.6e-10	0.11	0.06	0.94	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPT1	0.05	0.04	lasso	2	0.03	1.1e-04	5.53	6.1	8.1e-10	0.09	0.13	0.25	FALSE
16	GTEx	Cells Transformed fibroblasts	PPT1	0.32	0.29	enet	21	0.34	4.6e-26	6.39	6.1	8.8e-10	0.07	1.00	0.00	FALSE
25	GTEx	Lung	PPT1	0.19	0.15	lasso	3	0.14	1.1e-10	5.53	6.1	1.2e-09	0.10	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	CTPS	0.06	0.00	enet	14	0.02	3.3e-03	3.94	6.0	1.7e-09	0.02	0.04	0.04	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	PPT1	0.34	0.38	lasso	5	0.36	1.1e-12	6.15	6.0	1.9e-09	0.11	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	SCMH1	0.03	0.03	lasso	2	0.02	6.2e-03	-5.97	6.0	2.4e-09	-0.01	0.04	0.76	FALSE
32	GTEx	Skin Sun Exposed Lower leg	PPT1	0.22	0.26	lasso	6	0.26	2.1e-21	6.27	5.9	3.6e-09	0.11	1.00	0.00	FALSE
26	GTEx	Lung	CTPS1	0.06	0.04	lasso	3	0.04	2.4e-04	-4.13	-5.9	3.9e-09	0.00	0.01	0.98	FALSE
12	GTEx	Breast Mammary Tissue	RP11-69E11.4	0.15	0.05	enet	32	0.05	8.8e-04	3.70	5.9	4.1e-09	0.27	0.85	0.01	FALSE
20	GTEx	Esophagus Mucosa	PPT1	0.24	0.18	lasso	12	0.18	2.0e-12	6.40	5.9	4.1e-09	0.04	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	PPT1	0.20	0.10	lasso	6	0.11	2.8e-06	5.18	5.8	4.8e-09	0.09	0.94	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PPT1	0.06	0.00	bslmm	419	0.02	2.2e-03	2.92	-5.8	8.7e-09	-0.09	0.12	0.03	FALSE
39	NTR	Blood	CAP1	0.02	0.01	lasso	4	0.01	1.8e-05	6.39	5.7	9.4e-09	0.07	0.99	0.00	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PPT1	0.06	0.01	blup	57	0.02	6.3e-03	6.14	5.7	1.1e-08	0.10	0.04	0.65	FALSE
30	GTEx	Nerve Tibial	BMP8A	0.30	0.08	enet	20	0.23	3.9e-16	1.38	5.7	1.2e-08	0.29	0.96	0.00	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPT1	0.03	0.02	blup	57	0.02	7.6e-05	6.42	5.6	2.4e-08	0.02	0.03	0.97	FALSE
38	METSIM	Adipose	MYCL	0.03	0.02	bslmm	396	0.02	4.1e-04	-0.88	5.5	3.6e-08	0.18	0.24	0.03	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRIT1	0.16	0.09	blup	59	0.08	4.4e-04	-3.18	5.5	3.9e-08	0.33	0.06	0.05	FALSE
42	YFS	Blood	NFYC	0.04	0.02	blup	429	0.03	6.8e-10	-2.16	5.5	4.0e-08	0.12	1.00	0.00	FALSE
5	GTEx	Artery Aorta	CTPS1	0.10	0.00	enet	8	0.00	4.6e-01	-5.51	-5.3	9.0e-08	0.01	0.05	0.61	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIT1	0.24	0.21	enet	15	0.23	2.7e-25	-3.18	5.3	1.2e-07	0.24	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	RP1-39G22.7	0.08	0.01	lasso	5	0.00	1.8e-01	4.65	-5.3	1.4e-07	-0.10	0.14	0.03	FALSE
45	The Cancer Genome Atlas	Esophageal Carcinoma	PPT1	0.10	0.03	blup	57	0.06	6.5e-03	3.09	5.3	1.4e-07	0.04	0.02	0.47	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	PPT1	0.10	0.05	enet	29	0.07	1.9e-09	6.15	5.2	1.9e-07	0.06	1.00	0.00	FALSE