TWAS hub - CAP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1250	0.0400	3.6e-04	-0.003	NA	0.023	NA	0.006	8.5e-01	NA	5.0e-03	NA	1.0e-01
2	GTEx	Esophagus Mucosa	0.1230	0.0440	5.5e-04	0.021	NA	0.022	NA	0.049	1.5e-02	NA	1.2e-02	NA	3.4e-04
3	GTEx	Heart Left Ventricle	0.4145	0.1048	2.9e-03	-0.004	NA	0.013	NA	-0.004	6.6e-01	NA	6.1e-02	NA	6.3e-01
4	GTEx	Nerve Tibial	0.1297	0.0396	2.2e-05	0.096	NA	0.097	NA	0.087	2.6e-07	NA	2.3e-07	NA	1.0e-06
5	GTEx	Testis	0.1220	0.0480	2.8e-03	0.071	NA	0.068	NA	0.066	4.7e-04	NA	5.9e-04	NA	6.9e-04
6	GTEx	Thyroid	0.1240	0.0440	2.1e-04	0.023	NA	0.038	NA	0.031	7.0e-03	NA	6.1e-04	NA	2.0e-03
7	NTR	Blood	0.0175	0.0075	1.4e-03	0.013	0.009	0.010	0.011	0.014	2.5e-05	5.2e-04	3.3e-04	9.4e-05	1.8e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.1558	0.0308	5.6e-17	0.199	0.173	0.204	0.201	0.198	4.6e-25	9.7e-22	1.2e-25	2.5e-25	6.1e-25

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8
Osteoarthritis (self-reported)	4.0	5.1	11.6	0.8	3.4	2.8	3.3	2.4	0.6	2.0
Average weekly beer plus cider intake	3.6	5.3	12.0	0.3	-2.7	-3.3	-3.3	-3.5	0.9	-0.5
Angina	3.1	4.1	10.3	0.5	-3.1	-1.4	-0.9	1.3	-2.8	-3.2
Angina (self-reported)	3.1	4.1	10.4	0.3	-3.2	-1.6	-1.1	0.9	-2.8	-3.2
Worry too long after embarrassment	2.8	4.8	9.5	2.7	-0.3	2.6	2.2	3.1	-2.7	-1.5
Ever highly irritable/argumentative for 2 days	2.7	3.2	7.7	0.0	-1.8	-2.6	-2.8	-2.4	1.5	0.6
Heart attack/myocardial infarction (self-reported)	2.7	3.4	8.9	1.8	-2.0	0.3	0.3	1.9	-3.0	-2.8
Medication: Seretide 50 evohaler	2.6	3.0	11.2	-0.2	-3.3	-1.2	-1.7	-0.9	-1.6	-2.2
Sensitivity / hurt feelings	2.5	4.2	8.1	2.6	-0.8	2.3	1.9	2.9	-2.6	-1.6
Heart attack	2.5	3.3	7.8	2.2	-1.8	0.4	0.4	1.9	-2.8	-2.5
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.8	6.9	-1.1	-0.2	-2.2	-2.0	-2.6	2.0	1.2
Eye problems/disorders: Cataract	2.5	2.9	10.2	-0.2	0.6	-0.9	-1.0	-3.2	2.6	2.0
Number of treatments/medications taken	2.4	4.4	8.9	2.6	-0.2	2.1	2.3	2.3	-3.0	-2.0
Neuroticism score	2.3	4.7	10.0	2.9	-1.6	1.4	0.9	2.8	-3.2	-2.5
Worrier / anxious feelings	2.3	4.3	8.6	2.1	0.2	2.8	2.3	2.9	-2.6	-1.2
Medication: Amlodipine	2.2	3.1	7.5	0.2	0.6	2.7	1.9	2.7	-2.2	-1.3
Tinnitus: Yes, now most or all of the time	2.0	2.4	10.6	3.2	1.1	1.8	1.6	0.0	0.5	1.1
Neuroticism (Nagel 2018)	1.9	4.4	8.1	2.8	0.1	2.9	2.6	2.5	-2.3	-1.0
Neuroticism	1.9	4.5	11.0	3.3	-0.6	2.2	1.6	2.3	-2.9	-1.9
Neuroticism (2016)	1.8	2.6	7.3	2.7	-1.4	0.7	0.4	1.2	-2.2	-2.1
Number of incorrect matches in round	1.8	3.0	6.2	1.7	1.8	2.4	2.5	2.3	-0.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	5.1	0.2	-2.2	-1.6	-1.8	-1.9	-0.8	-1.6
Commuting to job workplace: Walk	1.8	1.9	5.6	-0.1	-0.1	-0.9	-1.0	-2.4	2.1	1.9
Guilty feelings	1.8	2.7	6.9	1.0	-0.4	1.9	2.0	2.6	-2.1	-1.0
Ever had hysterectomy (womb removed)	1.7	1.9	4.5	1.7	2.1	1.0	1.2	-0.1	1.3	1.8
Pack years adult smoking proportion	1.7	2.7	7.8	-0.9	-1.5	-2.8	-2.3	-1.8	1.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	6.1	2.5	1.2	2.2	2.4	1.8	-1.0	-0.1
Medication: Ventolin 100micrograms inhaler	1.7	2.2	4.2	1.4	0.6	1.9	2.0	1.9	-1.7	-0.7
Had major operations	1.7	2.0	5.7	0.1	-2.4	-1.9	-1.8	-1.6	-0.4	-1.1
Townsend deprivation index at recruitment	1.6	2.3	8.0	0.2	-2.8	-2.2	-1.8	-1.3	-0.2	-0.8
Age when periods started (menarche)	1.6	3.8	10.1	-1.5	1.3	-1.1	-1.5	-2.3	3.2	2.8
Chronic bronchitis/emphysema (father)	1.6	1.9	4.2	-1.4	-1.7	-1.9	-1.3	-2.1	1.0	0.3
Birth weight of first child	1.6	2.9	8.2	0.7	2.9	1.0	1.8	1.8	1.8	2.1
Pulse wave peak to peak time	1.6	1.8	4.6	-1.0	-0.2	-1.7	-2.1	-1.7	1.6	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	7.0	2.6	0.1	1.7	2.0	1.2	-1.6	-0.9
Illnesses of siblings	1.5	2.1	6.7	0.3	2.6	0.5	0.5	-0.1	2.0	2.3
Depression (self-reported)	1.5	1.8	4.7	-1.1	-1.7	-1.4	-2.2	-1.6	-0.1	-0.9
Exposure to tobacco smoke at home	1.5	1.7	3.8	-1.2	-1.6	-1.8	-1.9	-1.4	0.5	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	6.2	0.3	-1.8	-0.5	-1.4	0.5	-1.9	-2.5
Eye problems/disorders: None of the above	1.5	1.7	6.5	0.6	0.4	1.2	1.3	2.6	-1.6	-1.0
Medication: Blood pressure	1.5	2.6	5.9	0.9	0.1	2.1	1.8	1.7	-2.4	-1.8
Blood Platelet Count	1.4	16.5	39.4	0.2	-0.1	-5.0	-6.3	-4.9	5.7	3.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.3	0.1	-2.1	-1.2	-1.3	0.5	-1.2	-1.7
Hayfever, allergic rhinitis or eczema	1.4	3.0	8.2	0.2	2.0	2.4	2.9	2.4	-0.7	0.1
High blood pressure (mother)	1.4	1.9	4.1	-1.1	-0.5	-2.0	-1.9	-1.9	1.6	0.4
Nervous feelings	1.4	2.7	6.7	2.6	-1.2	1.4	1.1	1.9	-2.1	-1.5
Allergy	1.4	3.1	9.1	-0.7	-2.1	-2.6	-3.0	-2.0	0.6	-0.3
Pulse wave Arterial Stiffness index	1.4	1.6	4.2	0.6	0.6	1.7	2.1	1.6	-1.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.8	-1.4	-1.5	-1.2	-1.9	-1.8	-0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.7	0.2	1.4	-1.0	-0.0	-1.3	1.9	1.8
Worry (Nagel 2018)	1.3	2.7	6.3	2.5	-0.2	2.3	1.8	1.1	-2.0	-1.1
Blood White Count	1.3	9.6	22.1	-0.2	-1.8	-4.5	-4.7	-4.3	3.2	1.4
Chronotype (morning person)	1.3	3.1	9.3	1.9	1.7	2.1	1.8	3.1	-0.9	-0.1
Hearing difficulty/problems: Yes	1.3	1.9	3.7	0.8	1.9	1.7	1.7	1.0	1.1	1.7
Taking other prescription medications	1.3	2.0	4.7	2.2	0.3	1.6	2.0	1.0	-1.8	-1.0
Noisy workplace	1.3	1.6	5.3	0.2	1.5	2.3	2.0	0.9	0.2	1.0
Peak expiratory flow (PEF)	1.3	3.0	8.5	-2.0	2.0	0.7	0.7	-0.6	2.5	2.9
Blood clot in the leg (DVT)	1.3	1.6	4.8	-1.1	1.5	2.0	2.2	0.7	-0.4	0.3
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	6.5	-0.1	0.4	-1.7	-1.4	-1.3	2.5	1.9
Mood swings	1.3	2.3	4.7	1.8	-1.7	0.3	-0.0	1.9	-2.2	-2.0
Mineral and other dietary supplements	1.3	1.7	3.9	-1.6	-0.7	-2.0	-1.9	-1.6	0.6	-0.3
Irritability	1.3	2.2	6.6	0.0	-1.7	-0.1	-0.2	1.4	-2.5	-2.6
Pack years of smoking	1.3	1.9	5.6	-0.8	-1.4	-2.4	-2.0	-1.3	1.0	-0.0
Depression (Nagel 2018)	1.2	1.9	5.5	2.4	0.3	1.5	2.2	0.8	-1.1	-0.6
Allergy or Eczema	1.2	3.1	8.8	0.9	1.6	2.4	3.0	2.5	-1.0	-0.0
Frequency of depressed mood in last 2 weeks	1.2	1.7	7.8	2.8	-0.3	1.1	1.5	0.8	-1.2	-0.7
High blood pressure (siblings)	1.2	1.7	4.7	0.5	-2.1	-0.2	-0.4	0.7	-1.9	-2.2
Migraine (self-reported)	1.2	1.5	2.6	-1.2	0.2	-1.5	-1.6	-1.5	1.6	0.7
Pulse rate, automated reading	1.2	3.9	13.2	-0.1	1.4	-1.9	-1.4	-0.8	3.6	3.1
Osteoporosis (self-reported)	1.2	1.5	4.9	-0.2	-2.2	-0.5	-0.6	0.1	-1.6	-1.9
Relative age of first facial hair	1.1	2.3	5.1	-1.2	1.0	-1.7	-1.5	-1.7	2.3	1.5
Diabetes (mother)	1.1	1.4	4.4	-0.6	-2.1	-1.4	-0.9	-0.9	-1.0	-1.3
Current tobacco smoking	1.1	1.8	5.2	0.4	-2.3	-2.0	-1.5	-0.8	-0.6	-1.2
Qualifications: CSEs or equivalent	1.1	1.4	3.6	1.4	-1.1	-1.2	-1.2	-1.9	0.9	0.6
Chest pain or discomfort	1.1	1.6	4.1	-0.7	-1.9	-1.2	-0.4	-0.2	-1.6	-2.0
Hearing aid user	1.1	1.2	2.2	1.4	1.2	1.3	1.5	1.4	-0.3	0.4
Eye problems/disorders: Glaucoma	1.1	1.3	4.1	0.2	2.0	1.3	1.2	0.6	0.9	1.4
Myopia	1.1	1.6	4.3	-1.0	0.6	2.1	2.0	1.5	-1.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.8	-1.4	1.3	1.7	2.0	0.3	-0.4	0.3
Impedance of whole body	1.1	5.4	13.3	-2.4	-1.8	-3.6	-3.3	-2.2	2.0	0.8
HbA1C	1.0	1.1	3.6	-0.5	1.2	-0.5	0.4	-0.3	1.9	1.7
Severe depression (siblings)	1.0	1.2	2.4	-1.5	0.2	-1.0	-1.0	-1.3	1.6	0.9
Relative age voice broke	1.0	1.5	4.0	-1.5	1.1	-1.0	-0.4	-1.0	2.0	1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	5.3	2.3	0.8	0.7	1.3	0.8	-0.7	-0.3
Had menopause	1.0	1.3	4.5	-2.1	-0.6	0.8	0.8	1.1	-1.5	-0.9
Impedance of arm (right)	1.0	4.8	10.3	-1.9	-1.6	-3.2	-2.9	-2.8	2.1	1.1
Tense / ‘highly strung’	1.0	1.7	3.7	1.9	-0.3	1.7	1.2	1.3	-1.6	-1.1
Comparative body size at age 10	1.0	2.9	7.5	0.3	-1.1	1.9	2.2	1.4	-2.7	-1.9
Shortness of breath walking on level ground	1.0	1.2	3.3	-0.2	-1.0	0.4	0.5	1.8	-1.6	-1.4
Mother’s age at death	1.0	1.2	3.5	0.4	1.7	1.5	1.9	0.8	-0.3	0.6
Medication: Atorvastatin	1.0	1.2	4.3	-0.2	-2.1	-1.1	-1.3	-0.6	-0.9	-1.1
Ulcerative Colitis (UC)	0.9	1.7	5.7	-2.4	0.8	-0.8	-0.2	-1.2	1.7	1.5
Crohns Disease (2012)	0.9	1.5	4.4	-0.9	0.8	-1.2	-0.3	-0.9	2.1	1.8
Fasting Glucose	0.9	1.1	3.1	0.8	-1.8	-1.3	-0.4	-0.1	-1.1	-1.3
HDL Cholesterol	0.9	1.5	3.8	-1.5	1.1	0.2	0.3	-1.4	1.7	1.9
Hand grip strength (right)	0.9	2.5	6.6	-1.1	2.6	-0.3	0.3	-0.0	2.5	2.3
Average weekly fortified wine intake	0.9	1.0	3.1	-1.1	1.0	0.8	0.6	-1.8	0.9	1.0
Supplements: Glucosamine	0.9	1.2	3.2	1.0	1.3	0.7	0.7	-0.6	1.5	1.8
Illnesses of mother	0.9	1.1	2.9	1.2	0.7	1.7	1.4	1.1	-1.0	-0.3
Impedance of arm (left)	0.9	4.0	8.6	-2.2	-1.1	-2.9	-2.7	-2.3	2.0	1.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.8	0.7	-0.3	-1.1	-1.7	-1.5	1.2	0.8
Age at last live birth	0.9	1.3	4.1	2.0	1.3	1.0	0.9	1.3	-0.8	-0.6
Qualifications: nursing, teaching	0.9	1.3	4.7	0.3	1.0	2.0	2.2	0.8	-0.6	-0.1
Age started oral contraceptive pill	0.9	1.1	7.5	-2.7	0.9	-0.0	0.1	0.4	0.4	0.6
Basal cell carcinoma (self-reported)	0.9	1.1	4.4	-0.9	-2.1	-0.8	-1.2	-0.3	-0.7	-1.0
Ovarian Cancer	0.8	1.0	2.9	-1.2	1.7	0.9	0.4	-0.3	1.1	1.2
Prostate Cancer	0.8	1.2	3.5	-0.6	-0.1	-1.0	-0.4	-1.0	1.9	1.9
LDL Cholesterol	0.8	1.2	3.5	0.9	1.6	1.3	0.9	1.9	0.2	0.5
Lupus	0.8	1.3	4.1	-0.4	-0.4	-2.0	-1.1	-0.9	1.7	1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	5.9	-2.4	-0.2	-1.2	-0.7	-0.2	0.1	-0.1
Diabetes (father)	0.8	1.0	2.6	0.7	-1.2	-0.5	-0.5	1.3	-1.2	-1.6
Fed-up feelings	0.8	1.5	3.1	1.7	-1.8	0.2	-0.1	0.7	-1.7	-1.5
Impedance of leg (left)	0.8	3.8	9.7	-2.2	-1.4	-3.1	-2.8	-1.5	1.8	0.8
Alcohol usually taken with meals	0.8	1.3	6.2	-2.5	0.0	-1.2	-1.2	-1.0	0.5	-0.1
Had other major operations	0.8	0.9	1.9	1.2	1.2	0.7	1.0	0.1	1.0	1.4
Medication: Ramipril	0.8	1.1	3.0	0.3	-0.8	0.5	0.7	1.4	-1.7	-1.5
Medication: Simvastatin	0.8	1.1	2.7	-0.1	0.9	1.5	1.4	1.6	-1.1	-0.5
Number of live births	0.8	1.1	3.7	-0.3	-1.1	-1.7	-1.9	0.5	0.2	-0.6
Medication: Cholesterol lowering	0.8	1.2	4.0	0.2	-1.0	1.0	0.7	0.8	-2.0	-1.5
Standing height	0.8	7.7	24.4	-4.9	2.4	-2.3	-1.6	-2.2	3.6	2.4
Breastfed as a baby	0.8	1.0	5.4	-0.2	2.3	0.5	0.8	0.1	1.0	0.9
Birth weight	0.8	1.7	5.7	0.7	2.4	1.5	1.9	1.0	0.1	0.7
Medication: Omeprazole	0.8	1.0	1.9	-0.9	-1.3	-1.1	-0.8	-1.4	-0.6	-1.1
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.8	-1.7	-0.2	-1.2	-0.9	-1.5	-0.0	-0.7
Knee pain experienced in last month	0.8	1.3	2.8	1.1	1.5	1.5	1.7	1.2	0.0	0.5
Unable to work because of sickness or disability	0.8	1.0	2.0	-0.3	-1.4	-1.2	-1.4	-0.0	-0.8	-1.4
Commuting to job workplace: Cycle	0.8	0.9	2.0	-1.0	-1.3	-0.6	-0.4	1.4	-1.1	-1.1
Schizophrenia (2018)	0.7	1.5	3.8	1.9	-1.6	0.3	0.3	0.7	-1.5	-1.7
Reaction Time	0.7	1.3	2.5	1.6	0.1	1.1	0.7	1.4	-1.6	-1.3
Bipolar Disorder (2011)	0.7	0.7	1.6	1.3	-0.3	-0.8	-1.2	-0.9	0.9	0.6
Height	0.7	13.9	50.7	-7.1	2.9	-2.2	-1.4	-3.3	4.5	3.8
Impedance of leg (right)	0.7	3.4	8.6	-2.0	-1.6	-2.9	-2.9	-1.4	1.3	0.2
Maternal smoking around birth	0.7	1.1	4.8	-0.7	-0.4	-0.4	-0.6	-2.2	1.1	1.1
Stomach or abdominal pain in last month	0.7	0.9	3.1	-0.8	-0.9	-1.8	-1.2	-0.8	0.2	-0.4
Medication: Atenolol	0.7	0.9	2.5	-1.0	-1.6	-0.8	-0.6	-1.1	-0.7	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.1	0.8	1.2	1.4	1.4	0.9	-0.4	0.0
Falls in the last year	0.7	0.9	3.3	1.8	-0.8	-0.2	-0.5	-0.9	-1.0	-1.0
Hair/balding pattern: Pattern 3	0.7	1.0	3.6	1.1	-1.9	-0.8	-1.1	0.1	-0.9	-1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	3.4	0.1	1.1	1.5	1.9	0.9	-0.9	-0.2
Medication: Ibuprofen	0.7	0.8	2.8	0.3	-0.9	-0.2	-0.0	0.9	-1.5	-1.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.6	1.5	0.3	1.2	0.5	1.6	-0.5	-0.2
Loneliness, isolation	0.7	0.9	2.0	1.3	-0.0	1.2	1.3	1.4	-0.4	0.3
Smoking status: Current	0.7	1.1	3.3	0.7	-1.6	-1.8	-1.3	-0.9	0.2	-0.3
Number of self-reported non-cancer illnesses	0.7	1.3	4.0	0.3	0.8	1.7	2.0	1.3	-0.8	0.1
Number of operations (self-reported)	0.7	1.1	4.5	0.6	-1.1	-1.4	-0.8	-2.1	0.5	-0.1
Ulcerative Colitis	0.6	0.8	1.4	-1.1	0.1	-0.7	-0.8	-1.2	1.2	1.1
Hand grip strength (left)	0.6	1.6	4.3	-0.2	1.9	0.0	0.5	0.5	2.1	2.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.9	0.6	-1.4	-0.0	-0.1	0.8	-1.1	-1.4
Mouth/teeth dental problems	0.6	0.9	2.4	-0.6	0.8	-0.9	0.0	-1.0	1.5	1.4
Fluid intelligence score	0.6	1.3	3.7	-1.1	-1.1	0.9	0.8	-0.0	-1.9	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.4	-0.1	-1.0	-1.0	-0.6	0.2	-1.0	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	3.2	0.0	-1.4	-0.3	-0.7	0.1	-1.4	-1.8
Hair/balding pattern: Pattern 4	0.6	1.5	3.5	-0.7	1.8	1.1	0.8	-0.3	1.5	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	0.5	1.1	1.4	0.7	0.3	0.9	1.1
Medication: Allopurinol	0.6	0.7	2.1	1.4	0.9	0.9	1.3	-0.2	-0.4	-0.6
Mean time to correctly identify matches	0.6	1.1	2.0	1.2	0.1	1.2	0.5	1.3	-1.4	-1.3
Suffer from ‘nerves’	0.6	1.0	3.2	0.9	-1.8	-0.1	-0.9	0.3	-1.1	-1.2
Supplements: Vitamin C	0.6	0.7	2.3	0.7	0.8	1.5	1.4	0.3	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.0	-2.0	0.2	-1.7	-1.4	-0.7	1.0	0.4
Average weekly red wine intake	0.6	0.9	3.8	-2.0	1.0	0.5	-0.1	-0.4	0.8	1.0
Financial situation satisfaction	0.6	0.7	1.9	1.4	-0.3	-1.0	-0.9	-1.1	0.7	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.0	1.4	-0.8	-0.9	-1.0	-0.7	0.8	0.2
Medication: Lisinopril	0.6	0.8	1.7	-0.3	1.2	0.6	0.1	-1.0	1.3	1.2
Risk taking	0.6	0.8	1.8	1.0	0.1	-0.4	-1.0	-1.4	1.3	0.8
Depressed Affect (Nagel 2018)	0.5	1.1	2.8	1.7	-0.3	1.0	1.1	1.4	-1.1	-0.7
Irritable Bowel Disease (IBD)	0.5	1.3	6.8	-2.6	0.3	-1.2	-0.4	-0.9	1.0	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.9	-1.4	-1.2	1.1	0.7	-0.7	-1.7	-1.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	-1.3	0.5	-0.9	-0.1	-0.6	1.0	0.7
Waist Hip Ratio (WHR)	0.5	2.2	6.3	-0.9	-2.5	-2.0	-1.7	-0.8	-0.8	-1.6
Smoking Status	0.5	1.1	3.4	0.8	-1.8	-1.5	-1.4	-0.7	0.5	0.1
Lung FEV1/FVC ratio	0.5	2.7	6.7	-2.0	-1.0	1.8	0.8	1.0	-2.6	-2.2
Lung FVC	0.5	2.8	7.8	0.4	1.9	2.8	2.4	0.4	0.9	2.0
Medication for hormone replacement therapy	0.5	0.6	1.6	0.1	0.2	0.6	0.9	1.3	-1.0	-0.8
Hearing difficulty/problems with background noise	0.5	0.8	1.8	0.1	0.1	1.4	1.3	1.3	0.3	1.1
Pain all over the body in last month	0.5	0.5	1.1	-1.0	0.2	0.7	0.1	0.9	-0.8	-1.0
Time employed in main current job	0.5	0.5	2.2	0.3	0.8	1.0	1.5	0.6	-0.3	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	-1.0	-0.1	-0.5	-0.1	-0.5	1.1	1.3
Number of full brothers	0.5	0.7	2.6	0.3	-1.6	0.3	0.3	0.2	-1.2	-1.0
Qualifications: College or University degree	0.5	1.5	3.7	-1.9	-0.9	-1.5	-1.2	-1.5	1.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.3	0.8	-0.6	0.1	0.7	0.0	-1.5	-1.0
Illnesses of father: Heart disease	0.5	0.7	2.1	1.2	-0.4	0.9	0.4	0.1	-1.4	-1.1
Long-standing illness, disability or infirmity	0.5	0.8	2.2	1.5	0.2	1.2	1.4	0.6	-0.3	0.4
Ever had bowel cancer screening	0.5	0.5	3.2	-1.8	-0.1	0.2	0.4	0.2	-0.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	0.9	1.0	0.1	0.3	0.3	1.0	1.3
Asthma (self-reported)	0.5	1.0	2.2	1.5	0.7	1.3	1.5	1.0	-0.2	0.4
Average weekly champagne plus white wine intake	0.5	0.6	1.7	0.3	-0.0	0.6	1.1	1.3	-1.0	-0.9
Miserableness	0.5	0.8	2.9	1.7	-1.6	-0.4	-0.4	0.5	-0.7	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.5	0.3	0.2	0.8	1.1	1.2	0.4	0.8
Fractured/broken bones in last 5 years	0.5	0.6	1.7	1.3	-0.9	-0.2	-0.6	-1.1	-0.5	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.6	2.3	1.5	-0.0	0.9	0.9	0.7	0.2	0.3
Mean Putamen Volume	0.4	0.4	2.0	-0.4	-0.3	0.3	-0.2	1.4	-0.8	-0.7
Primary Biliary Cirrhosis	0.4	0.6	3.2	-1.8	-0.3	-1.2	-0.4	0.2	0.3	-0.1
Schizophrenia (2014)	0.4	0.8	3.6	1.9	0.1	1.2	0.8	0.8	-0.3	-0.1
Triglycerides	0.4	0.7	3.2	1.8	-0.2	-0.0	-0.4	-0.2	-0.8	-1.2
Heel T-Score	0.4	3.4	15.0	-0.9	0.9	2.2	1.9	3.9	-1.4	-0.4
Respiratory disease	0.4	0.8	2.5	1.6	0.9	0.8	1.5	0.8	-0.2	0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	2.5	-1.6	-0.8	0.3	0.6	-0.5	-0.6	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	1.4	-0.5	0.3	0.5	-0.2	-0.8	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	2.0	-0.4	1.4	0.6	0.8	-0.0	0.4	0.6
Sitting height	0.4	2.5	9.9	-3.1	2.0	0.2	0.8	-0.3	1.6	1.7
Forced vital capacity (FVC)	0.4	1.6	3.8	-1.9	0.9	-0.3	-0.6	-1.4	1.9	1.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	4.6	-2.1	0.6	0.0	-0.5	-1.2	1.4	1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.2	-1.2	0.4	0.8	1.5	0.8	-0.9	-0.6
Mouth/teeth dental problems: Dentures	0.4	0.8	1.8	-0.8	-0.3	0.9	0.5	1.1	-1.3	-1.2
Asthma	0.4	0.8	2.0	1.4	0.6	1.2	1.3	0.9	-0.2	0.5
Lung cancer (father)	0.4	0.5	1.2	1.0	-0.9	-0.8	-1.1	-0.2	-0.2	-0.6
Medication: Paracetamol	0.4	0.7	2.8	1.7	0.5	-0.4	0.1	-0.6	1.0	0.9
Exposure to tobacco smoke outside home	0.4	0.6	1.5	0.8	-0.8	-0.5	-0.3	0.5	-1.1	-1.2
Number of children fathered	0.4	0.4	1.2	-0.0	0.4	0.2	-0.3	-1.1	1.0	0.9
Age at first live birth	0.4	0.7	1.9	0.8	1.4	1.4	1.1	0.0	-0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.7	-1.3	-0.0	-0.8	-1.0	-0.7	0.5	0.1
Alcohol intake frequency.	0.4	0.9	3.3	-1.8	-0.5	-1.1	-1.6	-0.2	0.2	-0.0
Comparative height size at age 10	0.4	2.0	6.4	-2.5	1.3	-0.9	-0.6	-1.1	1.9	1.3
Number of full sisters	0.4	0.5	1.1	0.5	-1.0	0.1	-0.5	1.0	-1.0	-0.9
Leg pain on walking	0.4	0.5	1.5	-0.6	0.3	-0.3	-0.6	-0.9	1.2	1.0
Smoking status: Previous	0.4	0.5	1.5	0.7	-1.2	0.8	0.5	0.5	-1.0	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.5	1.2	-0.4	0.3	-0.0	0.6	-1.0	-0.7
Friendships satisfaction	0.4	0.5	1.5	0.6	-0.6	0.4	0.3	-0.9	1.0	1.2
Wears glasses or contact lenses	0.4	0.5	1.8	-0.6	0.7	1.0	1.3	0.3	0.1	0.4
Medication: Blood pressure	0.4	0.7	1.8	-1.3	-0.7	-1.2	-1.1	-0.8	0.4	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.5	0.4	-0.2	1.2	1.2	0.6	-0.9	-0.4
Illnesses of father: High blood pressure	0.4	0.4	1.3	-0.0	-0.1	0.5	0.8	0.7	-1.1	-0.9
Diastolic blood pressure, automated reading	0.4	1.4	3.8	0.1	1.9	1.1	1.9	1.0	0.6	1.1
Ever depressed for a whole week	0.4	0.5	1.9	0.8	-1.4	-0.7	-0.7	0.4	-0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	-1.1	-0.6	-0.7	-0.3	-0.9	-0.5	-1.0
Pain experienced in last month	0.4	0.7	1.9	0.4	-0.5	1.1	1.0	0.6	-1.4	-1.1
Supplements: Calcium	0.4	0.5	1.5	0.3	-0.4	0.8	0.8	1.2	-0.8	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.8	2.0	1.4	-1.3	-0.3	-0.3	0.1	-0.9	-1.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.0	-0.3	-0.8	1.1	1.0	0.5	-1.7	-1.0
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	-1.2	-0.5	-0.0	0.3	0.6	-0.6	-0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.8	-0.1	-0.9	-0.4	-0.9	0.7	0.1	-0.1
Crohns Disease (2017)	0.3	0.7	2.5	-1.6	-0.5	-1.5	-0.7	-0.5	0.4	-0.4
Breast Cancer	0.3	0.8	2.8	-1.7	-0.5	-1.1	-0.7	-0.1	-0.9	-1.0
Age at First Birth	0.3	0.5	1.1	0.9	-1.1	-0.2	-0.2	-0.4	-0.9	-1.0
Body Mass Index (BMI) (2010)	0.3	0.3	1.2	-0.0	-0.5	0.2	-0.3	0.6	-1.1	-1.0
Systolic Blood Pressure	0.3	1.3	4.2	0.8	-1.5	-0.1	-0.2	0.7	-1.8	-2.0
Hypothyroidism (self reported)	0.3	0.6	1.4	0.6	-1.0	-0.7	-1.2	-1.1	-0.3	-0.8
Supplements: Zinc	0.3	0.3	0.9	0.5	-0.5	0.2	0.2	1.0	-0.8	-0.7
Trunk fat percentage	0.3	1.1	3.7	-1.2	-0.6	-1.2	-1.1	-1.9	0.2	-0.6
Multivitamins +/- minerals	0.3	0.4	1.6	-0.3	0.7	0.6	0.5	-0.3	0.6	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.3	-1.0	-0.7	-0.4	-1.5	0.2	-0.2	-0.9
Father’s age at death	0.3	0.3	0.8	0.9	0.2	0.7	0.5	0.8	-0.5	-0.5
Happiness	0.3	0.4	0.9	0.7	-0.5	-0.9	-0.4	-0.3	0.8	0.7
Length of working week for main job	0.3	0.4	0.9	-0.8	-0.3	-0.7	-1.0	-0.6	0.4	0.1
Pulse wave reflection index	0.3	0.4	1.3	0.7	-1.1	0.4	0.1	-0.9	-0.5	-0.5
Gout (self-reported)	0.3	0.4	1.0	0.5	0.8	0.6	1.0	-0.3	-0.6	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	2.5	-1.5	1.0	0.2	-0.0	-0.5	1.6	1.5
Emphysema/chronic bronchitis	0.3	0.4	1.5	-1.2	-0.8	-0.3	-0.4	0.1	-0.5	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	-1.0	1.1	0.3	-0.4	-0.4	0.8	0.8
Neck or shoulder pain in last month	0.3	0.4	1.0	-0.3	-0.8	-1.0	-0.8	-0.1	-0.4	-0.6
Heart disease (mother)	0.3	0.4	1.2	-0.5	-1.1	-0.4	-0.5	-0.5	-0.6	-0.7
Medication for cholesterol	0.3	0.5	2.4	1.5	0.0	0.9	0.8	0.0	-0.6	-0.4
Back pain experienced in last month	0.3	0.4	1.4	0.0	-1.2	-1.0	-0.8	0.2	-0.5	-0.5
Breast cancer (self-reported)	0.3	0.4	2.7	1.6	-0.1	0.1	-0.2	0.2	-0.1	0.0
Ever taken oral contraceptive pill	0.3	0.4	1.4	0.6	-1.2	-0.2	-0.4	0.5	-0.6	-0.6
Cholesterol lowering medication	0.3	0.5	2.1	-1.5	-0.2	-0.7	-0.7	-0.4	0.5	0.3
Heart disease (siblings)	0.3	0.3	1.3	-0.5	0.1	1.0	1.2	-0.2	-0.1	0.3
Alcohol drinker status: Previous	0.3	0.3	1.5	-1.2	0.1	0.4	-0.2	0.2	-0.6	-0.6
Medication: Co-codamol	0.2	0.2	0.5	-0.0	0.7	0.6	0.7	-0.4	-0.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.6	-0.7	0.0	0.7	-0.2	-0.2	-0.1
Body mass index (BMI)	0.2	1.0	2.2	1.0	0.3	1.4	1.2	0.2	-1.5	-1.2
Trunk fat mass	0.2	0.7	2.7	-1.3	0.2	-0.7	-0.6	-1.7	0.3	-0.3
Past tobacco smoking	0.2	0.3	1.2	-1.1	0.7	-0.6	-0.5	-0.2	0.0	-0.7
Qualifications: None of the above	0.2	0.5	1.4	0.1	-0.0	-1.2	-1.1	-0.2	0.9	0.7
Diabetes (self-reported)	0.2	0.3	0.6	-0.6	-0.8	-0.5	-0.3	-0.2	0.7	0.7
Trunk fat-free mass	0.2	1.2	4.9	-1.1	2.2	1.2	1.3	0.3	0.0	0.1
Pulse rate	0.2	0.3	1.4	-0.4	-0.1	-1.2	-0.6	-0.2	0.5	-0.0
Prospective memory result	0.2	0.3	0.9	0.3	-0.5	0.9	-0.2	0.7	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.8	-1.4	0.7	0.4	0.1	-0.5	0.9	0.9
Trunk predicted mass	0.2	1.2	5.0	-1.1	2.2	1.2	1.3	0.2	0.1	0.2
Loud music exposure frequency	0.2	0.3	0.9	0.9	0.7	-0.0	0.0	-0.3	0.5	0.5
Headache pain in last month	0.2	0.3	0.9	0.6	-0.6	-0.9	-0.9	-0.2	-0.0	-0.3
Glaucoma (self-reported)	0.2	0.3	0.6	-0.2	0.3	0.0	-0.8	-0.6	0.8	0.6
Body fat percentage	0.2	0.8	2.6	-1.0	-0.6	-1.0	-0.9	-1.6	-0.1	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.9	-0.4	0.1	0.1	-0.9	-0.5	-0.5
Health satisfaction	0.2	0.3	2.2	-1.5	-0.0	-0.1	0.1	-0.0	-0.1	-0.2
Arm predicted mass (right)	0.2	0.9	3.2	-1.0	1.8	1.0	1.2	0.6	-0.5	-0.5
Family relationship satisfaction	0.2	0.3	1.5	0.5	-1.2	-0.2	-0.4	-0.4	-0.2	-0.3
Medication: Aspirin	0.2	0.3	0.7	-0.2	-0.8	0.3	0.3	0.6	-0.7	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.9	0.0	-0.1	-0.4	-0.3	-0.9	0.5	0.4
Whole body fat-free mass	0.2	1.0	4.3	-0.7	2.1	1.1	1.3	0.2	-0.1	-0.0
Whole body water mass	0.2	0.9	4.0	-0.8	2.0	1.0	1.1	0.1	-0.0	-0.0
Commuting to job workplace: Public transport	0.2	0.2	0.8	0.1	0.4	0.8	0.9	0.4	-0.4	-0.1
Medication: Bendroflumethiazide	0.2	0.4	2.1	1.5	-0.7	0.2	0.1	0.2	-0.5	-0.1
Medication: Paracetamol	0.2	0.3	2.0	1.4	0.3	-0.4	-0.1	-0.4	0.5	0.4
Alcohol drinker status: Never	0.2	0.2	0.5	-0.2	-0.5	-0.2	-0.6	-0.5	0.6	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.7	0.2	0.6	-0.9	-0.7	-0.8	1.3	1.0
Bipolar Disorder (2018)	0.1	0.2	0.5	-0.2	-0.1	-0.7	-0.7	-0.7	0.4	0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	-0.9	-0.5	-0.0	-0.1	0.8	-0.1	-0.3
Major Depression (MDD)	0.1	0.1	0.4	0.3	0.0	0.1	-0.4	0.7	0.2	0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.5	-0.7	0.2	-0.6	0.2	0.4	0.2	0.1
Rheumatoid Arthritis	0.1	0.2	1.1	-0.4	0.1	0.2	-1.0	-0.3	0.4	0.2
Blood Eosinophil Count	0.1	0.8	4.0	0.5	-1.0	-0.7	-0.6	-2.0	0.6	0.2
Blood Red Count	0.1	1.2	3.8	-1.0	1.9	0.3	1.6	0.5	0.9	1.2
BMI	0.1	0.9	2.7	1.1	-0.2	0.8	0.4	-0.5	-1.4	-1.6
Cardiovascular Disease	0.1	0.3	1.0	-0.4	-1.0	-0.1	-0.4	-0.2	-0.7	-0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.5	-0.3	-0.7	0.0	0.3	0.2	0.2	0.4
Average weekly spirits intake	0.1	0.1	0.3	0.2	0.3	0.5	0.3	0.4	-0.2	-0.1
Vitamin and mineral supplements	0.1	0.1	0.3	-0.2	-0.4	-0.3	-0.4	-0.2	-0.2	-0.6
Medication: Metformin	0.1	0.2	0.5	-0.2	-0.3	-0.4	0.4	-0.3	0.6	0.7
Leg fat-free mass (left)	0.1	0.7	3.2	-0.3	1.8	0.9	1.0	-0.4	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.8	-0.8	0.0	0.1	-0.9	0.2	0.1	-0.2
High blood pressure	0.1	0.3	0.9	-0.7	-0.0	0.9	0.8	0.3	-0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.4	0.4	-0.1	0.3	0.3	0.0	0.0
Medication: Levothyroxine sodium	0.1	0.2	0.9	1.0	-0.2	-0.4	-0.5	-0.1	-0.1	-0.2
Leg predicted mass (left)	0.1	0.7	3.4	-0.3	1.8	1.0	1.0	-0.2	-0.1	-0.1
Waist circumference	0.1	0.4	1.2	-1.1	-0.1	-0.2	-0.2	-0.9	-0.6	-0.9
Hair/balding pattern: Pattern 2	0.1	0.2	0.8	-0.1	-0.3	0.0	-0.1	0.3	-0.5	-0.9
Weight	0.1	0.6	1.8	-1.4	1.3	0.2	0.4	-0.9	0.2	-0.1
Arm fat percentage (right)	0.1	0.3	1.5	-0.3	-0.4	-0.2	-0.3	-1.2	-0.4	-0.7
Hip circumference	0.1	0.6	1.9	-1.4	1.4	0.2	0.2	-0.8	0.3	0.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	0.4	-0.5	0.1	0.0	0.3	0.4
Medication: Lansoprazole	0.1	0.1	0.6	0.2	-0.3	-0.4	-0.2	-0.8	0.2	-0.1
Arm fat mass (right)	0.1	0.3	0.6	-0.1	0.4	0.5	0.5	-0.6	-0.7	-0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.7	-0.1	0.1	-0.2	-0.2	-0.6	-0.6
Leg fat percentage (right)	0.1	0.5	1.6	-0.5	-0.7	-0.2	-0.2	-0.8	-0.8	-1.3
Arm fat-free mass (right)	0.1	0.8	2.5	-1.4	1.6	0.7	1.0	0.2	-0.4	-0.4
Whole body fat mass	0.1	0.2	1.0	-0.6	0.4	-0.1	-0.0	-1.0	-0.2	-0.6
Leg fat mass (right)	0.1	0.3	1.1	-0.2	0.2	0.3	0.2	-0.6	-0.8	-1.1
Overall health rating	0.1	0.3	0.7	0.7	-0.0	0.6	0.5	-0.3	-0.9	-0.6
Hypertension (Self-reported)	0.1	0.4	0.8	-0.7	-0.5	0.9	0.8	0.4	-0.8	-0.5
Leg fat-free mass (right)	0.1	0.7	3.3	-0.3	1.8	0.8	1.0	-0.5	0.2	0.1
Arm fat percentage (left)	0.1	0.3	1.0	-0.3	-0.3	-0.0	-0.2	-1.0	-0.5	-0.8
Diabetes diagnosed by doctor	0.1	0.1	0.6	0.4	-0.8	-0.3	-0.2	0.1	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.7	0.7	0.2	0.8	-0.0	-0.6	-0.1	-0.1
Medication: Aspirin	0.1	0.2	0.8	-0.4	-0.9	0.1	0.2	0.2	-0.5	-0.4
Medication: Gliclazide	0.1	0.1	0.5	-0.6	-0.5	-0.3	0.1	-0.7	0.1	0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	0.1	0.6	0.0	-0.0	0.6	0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	1.0	-0.3	0.2	1.0	0.2	-0.3	0.2	0.4
Leg predicted mass (right)	0.1	0.7	3.7	-0.4	1.9	0.8	1.0	-0.5	0.3	0.2
Arm fat mass (left)	0.1	0.3	0.4	-0.2	0.6	0.6	0.5	-0.4	-0.6	-0.7
Ever smoked	0.1	0.2	0.7	0.1	-0.8	-0.4	-0.2	-0.6	0.4	0.6
Basal metabolic rate	0.1	0.7	3.5	-0.7	1.9	0.9	1.1	-0.1	-0.1	-0.1
Leg fat percentage (left)	0.1	0.3	1.1	-0.5	-0.6	0.1	0.1	-0.6	-0.9	-1.1
Arm fat-free mass (left)	0.1	0.7	2.4	-1.0	1.6	0.8	1.1	0.1	-0.2	-0.2
Leg fat mass (left)	0.1	0.3	0.8	-0.2	0.3	0.5	0.4	-0.5	-0.8	-0.9
Arm predicted mass (left)	0.1	0.7	2.0	-1.1	1.4	0.9	1.1	0.1	-0.4	-0.3
Hair Pigment	0.0	1.2	4.0	-1.4	-0.6	-0.9	-2.0	-1.0	-0.1	-1.3
Tanning	0.0	0.3	0.8	-0.2	0.9	0.6	0.8	0.2	0.2	0.6
Systolic blood pressure, automated reading	0.0	0.1	0.7	-0.8	-0.2	-0.1	0.2	0.5	-0.1	-0.1
Financial difficulties in last 2 years	0.0	0.1	0.3	0.5	-0.1	-0.1	-0.3	-0.4	0.1	0.0
High cholesterol (Self-reported)	0.0	0.1	0.4	-0.6	-0.1	0.2	-0.0	-0.1	-0.4	-0.3

Hub : Genes

CAP1

Models

Trait associations