Hub : Genes

SEPT8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.153	0.050	2.6e-04	0.122	NA	0.101	NA	0.114	2.1e-09	NA	5.3e-08	NA	6.9e-09
2	GTEx	Esophagus Gastroesophageal Junction	0.224	0.072	6.3e-05	0.085	NA	0.047	NA	0.097	5.5e-04	NA	8.2e-03	NA	2.2e-04
3	GTEx	Skin Not Sun Exposed Suprapubic	0.152	0.053	1.9e-03	0.170	NA	0.141	NA	0.169	1.2e-09	NA	3.6e-08	NA	1.4e-09
4	GTEx	Skin Sun Exposed Lower leg	0.459	0.057	0.0e+00	0.349	NA	0.324	NA	0.332	7.0e-30	NA	1.7e-27	NA	3.2e-28

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	3.9	-0.0	-2.0	0.6	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.1	2.9	-0.1	-1.7	1.1	-0.5
Depressed Affect (Nagel 2018)	0.6	1.3	4.5	-0.4	2.1	0.8	0.3
Depression (Nagel 2018)	1.2	1.8	5.7	-0.6	2.4	1.0	0.5
Intelligence (Savage-Jansen 2018)	2.8	8.5	11.4	-3.3	1.0	3.4	3.3
Neuroticism (Nagel 2018)	0.9	2.1	8.2	-0.1	2.9	0.2	0.1
Schizophrenia (2018)	0.2	0.3	0.9	-0.1	-0.6	0.9	-0.2
Schizophrenia vs Biploar Disorder	2.0	2.6	5.3	1.8	-0.1	-2.3	-1.5
Worry (Nagel 2018)	1.1	2.3	3.6	1.2	1.9	-1.6	-1.2
Alzheimer’s Disease (in mother)	1.4	1.6	2.2	1.5	0.2	-1.4	-1.5
Alzheimer’s Disease (in father)	0.9	1.0	1.5	-1.2	0.2	1.1	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	0.3	1.1	-0.2	-0.4
Crohns Disease (2017)	12.4	27.1	52.6	4.5	7.2	-4.3	-4.1
Irritable Bowel Disease (IBD)	8.9	21.2	46.2	3.9	6.8	-3.7	-3.2
Ulcerative Colitis (UC)	2.3	4.2	11.1	1.6	3.3	-1.4	-1.0
Major Depression (MDD)	0.6	0.7	0.9	0.5	0.9	0.9	-0.9
Reaction Time	4.1	7.8	12.1	3.3	0.1	-2.9	-3.5
Verbal and Numeric Reasoning (VNR)	2.9	7.1	10.8	-3.0	-0.2	3.3	3.0
Breast Cancer	1.9	4.6	17.8	0.3	-4.2	-0.0	-0.8
Ovarian Cancer	0.3	0.3	0.9	0.2	-0.9	0.3	-0.6
Prostate Cancer	2.7	3.8	5.4	-2.3	0.8	2.0	2.3
Age at First Birth	0.7	1.0	1.4	-1.1	0.1	1.2	1.1
Bipolar Disorder (2011)	1.7	1.6	2.6	-1.6	-0.2	1.6	1.2
Body Mass Index (BMI) (2010)	1.0	1.4	1.6	1.2	-1.1	-0.9	-1.3
Coronary Artery Disease (CAD)	2.6	3.1	3.9	1.9	-1.4	-2.0	-1.8
Crohns Disease (2012)	7.4	11.9	25.6	2.7	5.1	-3.0	-2.4
Mean Putamen Volume	0.4	0.4	1.5	0.1	1.2	-0.3	0.1
Fasting Glucose	2.5	3.0	4.4	2.0	0.8	-1.8	-2.1
HbA1C	0.2	0.2	0.4	0.4	0.3	-0.6	-0.4
HDL Cholesterol	2.1	3.6	6.7	-1.5	2.6	1.8	1.4
LDL Cholesterol	0.1	0.2	0.5	0.5	-0.3	-0.7	-0.3
Lupus	1.0	1.5	5.9	-0.2	2.4	-0.3	-0.1
Neuroticism (2016)	0.2	0.3	0.8	0.4	0.9	-0.5	-0.4
Primary Biliary Cirrhosis	0.5	0.7	1.2	1.1	-0.2	-0.7	-1.1
Rheumatoid Arthritis	1.3	1.7	2.6	-1.5	0.5	1.3	1.6
Schizophrenia (2014)	0.2	0.4	0.7	0.2	-0.9	0.8	-0.5
Triglycerides	2.1	3.4	10.2	-1.0	-3.2	1.1	1.0
Type 2 Diabetes (T2D) (2012)	3.5	4.0	6.8	-2.3	0.3	1.9	2.6
Ulcerative Colitis	1.8	2.5	5.4	1.5	2.3	-1.1	-1.2
Blood Eosinophil Count	16.0	122.9	404.0	-5.5	-20.1	5.3	5.4
Blood Platelet Count	6.1	70.7	198.8	-5.5	-14.1	4.9	5.5
Blood Red Count	0.1	0.6	2.1	-0.3	-1.5	0.4	0.1
Blood White Count	8.2	61.0	174.2	-4.8	-13.2	5.1	4.5
Heel T-Score	1.3	10.1	11.8	-3.4	-2.4	3.4	3.3
BMI	0.5	2.7	9.4	-0.5	-3.1	0.9	0.4
Height	5.2	100.0	356.6	3.8	18.9	-4.2	-3.3
Waist Hip Ratio (WHR)	0.3	1.3	3.1	-0.7	1.8	-0.6	1.1
Systolic Blood Pressure	0.5	2.5	7.6	-1.1	-2.8	0.2	1.2
Smoking Status	0.2	0.4	0.5	0.7	0.2	-0.7	-0.6
Allergy or Eczema	10.9	28.6	37.7	-5.9	-2.8	6.1	5.8
Cardiovascular Disease	1.1	3.6	11.0	-1.1	-3.3	1.0	1.0
Hypothyroidism (self reported)	2.3	5.3	6.2	2.4	2.5	-2.2	-2.2
Respiratory disease	22.1	49.1	58.7	-7.7	-5.2	7.6	7.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	4.1	0.0	-2.0	0.3	-0.1
Lung FEV1/FVC ratio	3.4	17.5	42.5	2.7	6.5	-4.0	-2.0
Lung FVC	0.9	4.6	12.2	-1.3	-3.5	1.9	1.0
Neuroticism	0.6	1.4	5.4	0.2	2.3	-0.0	-0.5
Chronotype (morning person)	4.9	11.3	15.6	-4.0	-1.4	3.5	3.9
Hair Pigment	0.0	0.8	1.3	1.1	0.1	-1.1	-0.9
Tanning	0.0	0.2	0.3	0.4	-0.0	-0.5	-0.4
Hand grip strength (left)	4.7	12.4	40.0	1.7	6.3	-2.0	-1.6
Number of treatments/medications taken	2.4	4.2	8.0	-1.5	-2.8	2.2	1.4
Average weekly spirits intake	1.9	2.4	3.6	-1.9	0.0	1.6	1.9
Sensitivity / hurt feelings	0.9	1.6	4.0	-0.9	2.0	0.7	0.9
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.2	-1.4	2.3	1.3	1.3
Hearing difficulty/problems: Yes	0.4	0.6	1.4	-0.9	-0.3	1.2	0.4
Relative age of first facial hair	0.1	0.3	0.6	0.6	-0.5	0.1	-0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	0.3	-1.0	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	-0.3	0.0	0.7	0.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.4	1.1	0.3	-1.0	-1.2
Systolic blood pressure, automated reading	0.2	0.6	2.2	-0.1	-1.5	-0.2	0.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	-1.1	0.7	0.7	1.2
Angina	0.4	0.5	2.1	-0.0	-1.5	-0.2	-0.0
Medication for hormone replacement therapy	1.0	1.1	3.3	-0.6	-1.8	0.8	0.3
Vitamin and mineral supplements	0.6	0.8	1.2	0.7	-1.1	-1.1	-0.6
Supplements: Zinc	0.8	0.9	1.1	-1.0	0.9	1.0	0.9
Medication: Co-codamol	3.7	4.3	6.8	-2.3	-0.7	2.6	2.1
Medication: Metformin	1.6	2.2	8.8	-0.0	-3.0	0.3	-0.0
Diabetes (father)	0.8	1.0	1.3	-1.1	-0.8	1.0	1.1
Diabetes (mother)	0.2	0.2	0.6	0.1	-0.8	-0.6	-0.1
Severe depression (siblings)	2.6	2.9	5.4	-1.8	-0.4	2.3	1.7
Pack years adult smoking proportion	0.6	0.9	3.6	0.1	1.9	-0.4	0.0
Impedance of leg (right)	0.3	1.4	3.5	-0.0	-1.9	-1.3	0.5
Leg fat-free mass (left)	2.5	13.4	51.7	0.9	7.2	-0.4	-1.0
Trunk fat percentage	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.2
Hand grip strength (right)	4.5	12.2	43.0	1.4	6.6	-1.6	-1.3
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.1	-0.0	0.2	0.2
Current tobacco smoking	1.1	1.8	2.4	1.6	0.8	-1.4	-1.6
Average weekly fortified wine intake	1.4	1.7	3.1	1.4	0.5	-1.8	-1.2
Maternal smoking around birth	0.4	0.5	1.8	-0.2	1.3	-0.4	0.2
Fed-up feelings	0.5	1.0	3.7	-0.1	1.9	-0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	8.2	-1.0	2.9	1.3	0.9
Relative age voice broke	0.4	0.6	1.2	0.9	0.5	-0.1	-1.1
Taking other prescription medications	2.2	3.5	4.2	-1.6	-2.0	2.0	1.7
Age when periods started (menarche)	2.8	6.8	11.3	2.3	3.4	-2.5	-2.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.3	-0.9	1.5	1.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.1	-1.3	0.1	1.3	1.5
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.1	0.1	0.2	-0.3	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.3	0.7	-0.3	0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.4	0.4	0.7	0.2
High blood pressure	2.3	6.3	24.8	0.1	-5.0	0.3	-0.5
Hayfever, allergic rhinitis or eczema	11.1	24.0	28.3	-5.3	-3.4	5.3	5.3
Multivitamins +/- minerals	2.0	2.5	3.4	-1.7	0.9	1.7	1.8
Stomach or abdominal pain in last month	1.0	1.3	4.8	0.3	2.2	-0.5	-0.2
Supplements: Glucosamine	4.0	5.2	7.5	-2.7	0.0	2.6	2.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	-0.0	1.0	0.2	-0.3
Medication: Atenolol	1.5	1.8	7.2	-0.1	-2.7	0.2	0.0
Medication: Levothyroxine sodium	0.7	1.1	1.7	1.1	1.3	-1.0	-0.9
Sitting height	2.4	16.9	65.4	1.0	8.1	-0.6	-0.9
Chronic bronchitis/emphysema (father)	0.6	0.7	2.7	-0.1	-1.6	0.2	0.1
High blood pressure (mother)	0.6	0.8	1.9	0.1	-1.4	1.0	-0.5
Body mass index (BMI)	0.3	1.4	3.3	-0.7	-1.8	1.1	0.6
Impedance of leg (left)	0.5	2.4	8.1	-0.0	-2.9	-1.1	0.5
Leg predicted mass (left)	2.5	13.0	50.6	0.8	7.1	-0.3	-0.9
Trunk fat mass	0.2	0.9	3.5	0.0	1.9	-0.1	0.1
Waist circumference	0.0	0.2	0.3	-0.4	0.5	0.1	0.5
Number of incorrect matches in round	1.2	2.0	4.0	1.5	0.1	-2.0	-1.3
Past tobacco smoking	0.6	1.0	3.4	0.5	1.8	-0.6	-0.4
Alcohol usually taken with meals	0.1	0.2	0.4	-0.2	-0.7	0.6	0.1
Nervous feelings	0.2	0.5	0.8	-0.8	-0.1	0.5	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.3	0.7	2.3	-0.9	-0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.1	-0.9	0.3	-0.4
Hair/balding pattern: Pattern 2	1.3	1.7	6.4	-0.3	2.5	0.3	0.2
Had menopause	0.7	0.9	2.1	1.1	-0.2	-0.4	-1.4
Had other major operations	0.8	1.0	2.0	0.6	1.4	-1.0	-0.6
Forced vital capacity (FVC)	0.5	1.8	7.0	0.1	2.6	-0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.9	-1.5	0.0	1.0	1.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	-0.3	-0.4	1.0	-0.3
Qualifications: None of the above	0.5	1.1	2.0	1.1	1.0	-1.4	-0.7
Financial difficulties in last 2 years	0.4	0.5	0.8	0.8	0.6	-0.9	-0.6
Mouth/teeth dental problems	0.5	0.7	2.5	-0.1	-1.6	0.6	-0.1
Heart attack	0.7	0.9	2.7	0.5	-1.6	-0.6	-0.4
Allergy	17.3	39.8	43.8	6.6	5.5	-6.5	-6.5
Pain all over the body in last month	2.1	2.3	2.5	-1.5	1.4	1.6	1.5
Diabetes (self-reported)	0.6	1.0	3.7	0.3	-1.9	-0.2	-0.2
Hayfever/allergic rhinitis (self-reported)	5.8	7.7	10.5	-3.1	-1.4	2.9	3.2
Medication: Ramipril	0.5	0.7	2.6	-0.0	-1.6	-0.2	0.0
Medication: Simvastatin	0.1	0.1	0.2	-0.1	0.3	-0.2	0.4
Fluid intelligence score	2.4	5.1	9.9	-2.4	0.3	3.1	2.1
Illnesses of siblings	1.4	1.9	7.5	0.1	2.7	-0.3	0.3
Neuroticism score	0.6	1.3	5.0	-0.2	2.2	0.3	0.1
Weight	1.0	4.7	18.5	0.4	4.3	-0.3	-0.4
Impedance of arm (right)	0.3	1.4	3.5	1.2	0.1	-1.9	-0.7
Arm fat percentage (right)	0.4	1.4	4.0	-0.6	-2.0	0.8	0.8
Trunk fat-free mass	2.5	14.6	57.2	0.7	7.6	-0.3	-0.8
Hip circumference	0.0	0.2	0.3	0.5	0.5	0.0	-0.5
Time employed in main current job	0.1	0.1	0.2	0.3	0.1	-0.5	-0.0
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.0	0.5	0.4	-0.1
Father’s age at death	3.1	4.2	5.2	2.1	2.3	-1.8	-1.9
Worrier / anxious feelings	1.0	1.8	2.4	1.4	0.8	-1.6	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	7.2	-0.5	2.7	0.5	0.4
Falls in the last year	0.6	0.8	2.1	0.8	0.6	-1.4	-0.4
Hair/balding pattern: Pattern 3	1.2	1.8	7.0	-0.4	-2.7	0.3	0.3
Number of live births	3.4	4.8	6.7	2.5	-0.9	-2.6	-2.4
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	14.9	0.8	3.9	-1.3	-0.6
Pulse rate	0.2	0.4	0.7	-0.6	-0.2	0.9	0.6
Happiness	3.4	4.2	4.6	-2.1	1.9	2.2	2.1
Noisy workplace	1.3	1.6	5.5	0.5	-2.4	-0.4	-0.6
Qualifications: A levels/AS levels or equivalent	1.4	3.2	5.9	-1.9	-1.0	2.4	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.5	-1.2	0.1	1.1	1.2
Mouth/teeth dental problems: Dentures	0.5	0.8	2.9	-0.3	1.7	0.5	0.4
Asthma	27.6	54.4	64.0	-8.0	-5.7	7.8	7.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.2	0.9	-0.3	0.5
Medication: Cholesterol lowering	0.7	1.0	3.7	-0.3	-1.9	-0.3	0.5
Depression (self-reported)	0.3	0.4	0.6	-0.7	-0.0	0.8	0.5
Medication: Lansoprazole	0.4	0.4	0.6	-0.8	0.1	0.8	0.7
Prospective memory result	1.0	1.3	2.4	0.7	-1.6	-1.5	-0.1
Lung cancer (father)	0.5	0.6	1.1	-0.6	1.0	0.9	0.4
Illnesses of mother	0.2	0.3	0.5	0.4	0.7	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	16.4	1.6	4.0	-2.0	-1.5
Pulse wave Arterial Stiffness index	1.9	2.2	3.2	1.7	-0.2	-1.6	-1.8
Impedance of arm (left)	0.2	0.7	1.8	0.7	0.8	-1.3	-0.2
Arm fat mass (right)	0.1	0.3	0.7	-0.3	0.8	0.5	0.4
Trunk predicted mass	2.5	14.2	56.0	0.6	7.5	-0.2	-0.7
Standing height	5.0	49.4	177.8	2.6	13.3	-2.8	-2.3
Length of working week for main job	0.2	0.2	0.3	-0.3	-0.4	0.2	0.5
Exposure to tobacco smoke at home	2.9	3.3	4.5	2.0	1.0	-2.1	-1.8
Breastfed as a baby	0.5	0.6	0.9	0.9	0.1	-0.9	-0.9
Tense / ‘highly strung’	1.0	1.7	4.7	0.6	2.2	-1.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	5.5	-1.6	0.9	2.4	1.0
Hair/balding pattern: Pattern 4	2.3	5.6	6.7	2.4	-2.3	-2.6	-2.1
Birth weight of first child	1.5	2.7	6.2	1.4	2.5	-0.9	-1.3
Peak expiratory flow (PEF)	1.1	2.7	9.7	-0.6	3.1	0.2	0.7
Pulse wave reflection index	0.9	1.1	1.6	0.9	-1.2	-1.3	-0.7
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.7	0.7	0.8	-0.2	-0.8
Loud music exposure frequency	2.2	2.4	5.5	-1.4	-1.1	2.3	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-0.6	1.1	1.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.0	0.3	-1.7	-0.9	-0.2
Blood clot in the leg (DVT)	0.0	0.1	0.1	0.3	0.2	-0.0	-0.3
Medication: Paracetamol	0.5	0.8	2.6	-0.4	1.6	0.0	0.7
Headache pain in last month	0.1	0.2	0.4	0.4	0.6	-0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	8.6	0.8	2.9	-0.3	-0.9
Glaucoma (self-reported)	0.5	0.5	1.1	0.6	-1.1	-0.6	-0.6
Gout (self-reported)	1.5	2.0	3.0	1.5	1.3	-1.0	-1.7
Hypothyroidism/myxoedema (self-reported)	1.6	3.0	7.0	1.3	2.6	-1.5	-1.1
Medication: Amlodipine	1.5	2.1	6.7	-0.5	-2.6	1.2	0.2
Medication: Ventolin 100micrograms inhaler	8.0	10.3	12.9	-3.6	-2.1	3.3	3.6
Birth weight	0.8	1.8	5.2	0.9	2.3	-0.8	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.8	-0.2	-1.3	-0.3	0.4
High blood pressure (siblings)	2.3	3.3	10.3	-0.9	-3.2	1.2	0.6
Forced vital capacity (FVC), Best measure	0.5	2.0	6.4	0.7	2.5	-0.5	-0.9
Body fat percentage	0.2	0.8	1.9	-0.6	-1.4	0.5	0.8
Leg fat percentage (right)	1.1	3.9	10.3	-1.4	-3.2	1.1	1.5
Arm fat-free mass (right)	2.0	10.2	40.7	0.0	6.4	0.2	-0.2
Exposure to tobacco smoke outside home	2.1	2.8	7.6	1.1	2.8	-1.4	-0.7
Comparative body size at age 10	0.8	2.3	4.5	-1.5	-1.2	2.1	1.0
Number of full brothers	1.0	1.3	1.8	1.3	0.3	-1.3	-1.3
Worry too long after embarrassment	0.3	0.5	1.9	0.2	1.4	0.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.6	0.1	1.3	0.6	-0.5
Wheeze or whistling in the chest in last year	4.1	7.3	10.3	-3.1	-1.5	2.6	3.2
Number of children fathered	0.3	0.4	1.0	0.4	1.0	-0.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.8	4.7	1.9	-2.2	-1.6	-2.0
Age at first live birth	1.4	2.4	3.2	-1.6	-1.4	1.8	1.4
Pulse wave peak to peak time	1.8	2.1	2.8	-1.6	1.0	1.5	1.7
Health satisfaction	0.9	1.1	3.6	-0.4	-1.9	0.9	-0.1
Shortness of breath walking on level ground	2.6	3.1	5.3	-1.7	-1.5	2.3	1.3
Qualifications: College or University degree	2.2	6.8	10.6	-2.7	-2.0	3.3	2.3
Eye problems/disorders: None of the above	1.2	1.4	2.7	-1.2	1.7	0.6	1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	0.6	0.7	-0.9	-0.6
Emphysema/chronic bronchitis	0.3	0.4	0.8	0.6	0.4	-0.9	-0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.4	-0.6	-0.3	-0.6
Neck or shoulder pain in last month	1.0	1.4	2.0	-1.3	1.4	0.6	1.3
Medication: Blood pressure	1.9	3.4	13.1	0.3	-3.6	-0.4	-0.2
Angina (self-reported)	0.6	0.8	3.0	-0.4	-1.7	0.1	0.4
Migraine (self-reported)	0.9	1.2	1.7	-1.2	0.2	1.3	1.2
Medication: Ibuprofen	0.2	0.2	0.7	0.1	0.8	-0.2	0.1
Medication: Allopurinol	2.4	3.2	5.1	2.2	0.4	-1.6	-2.3
Medication: Omeprazole	0.1	0.1	0.3	0.1	-0.5	-0.5	0.2
Medication: Seretide 50 evohaler	6.1	7.0	12.1	-2.3	-3.5	2.3	2.4
Mean time to correctly identify matches	2.9	5.5	8.7	2.8	-0.3	-2.3	-2.9
Heart disease (mother)	0.5	0.6	0.9	0.8	0.3	-0.9	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.9	-0.7	1.0	1.4	0.4
Whole body fat mass	0.1	0.5	1.5	-0.4	1.2	0.4	0.5
Leg fat mass (right)	0.1	0.6	0.9	-0.9	-0.2	0.7	1.0
Arm predicted mass (right)	2.0	10.3	41.1	0.2	6.4	0.1	-0.4
Pulse rate, automated reading	0.7	2.3	3.0	-1.4	-1.7	1.6	1.3
Alcohol intake frequency.	0.2	0.4	1.2	0.6	0.1	0.4	-1.1
Comparative height size at age 10	4.2	23.3	91.4	0.9	9.6	-0.6	-0.8
Number of full sisters	0.6	0.8	3.0	-0.0	1.7	-0.2	-0.1
Suffer from ‘nerves’	0.3	0.5	1.3	0.2	1.1	-0.7	-0.3
Overall health rating	0.1	0.3	0.5	-0.5	0.3	0.7	0.4
Chest pain or discomfort	1.3	1.9	2.7	-1.4	-1.2	1.6	1.2
Had major operations	3.5	4.1	5.7	-2.0	-1.6	2.4	2.1
Age at last live birth	0.1	0.2	0.5	0.3	-0.7	-0.4	-0.2
Family relationship satisfaction	2.1	2.6	3.2	-1.6	1.8	1.6	1.4
Leg pain on walking	0.9	1.2	1.8	1.1	-1.1	-0.7	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.8	0.4	0.1	-0.9	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.1	0.6	0.6	-0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.1	-0.8	-1.0	1.0	0.7
Medication: Aspirin	0.8	1.1	4.2	0.3	-2.1	-0.1	-0.4
Supplements: Vitamin C	0.4	0.5	0.9	-0.4	1.0	0.7	0.6
Knee pain experienced in last month	0.1	0.2	0.5	-0.1	-0.7	0.3	-0.0
Hypertension (Self-reported)	2.1	5.9	23.3	-0.2	-4.8	0.6	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	0.4	-1.0	-0.5	-0.3
Illnesses of father: Heart disease	1.6	2.3	6.3	-1.0	-2.5	1.0	0.9
Illnesses of siblings: Diabetes	1.6	2.0	3.1	-1.8	-0.2	1.7	1.4
Smoking status: Previous	0.6	0.9	3.0	-0.5	-1.7	0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.1	19.2	1.3	4.4	-1.6	-1.1
Whole body fat-free mass	2.5	14.4	56.2	0.7	7.5	-0.2	-0.8
Leg fat-free mass (right)	2.3	12.5	48.6	0.8	7.0	-0.2	-0.9
Arm fat percentage (left)	0.3	1.4	3.0	-0.9	-1.7	1.0	1.0
Average weekly red wine intake	0.9	1.3	2.0	-1.3	-0.4	1.2	1.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	-0.6	0.5	0.4	0.8
Mood swings	0.3	0.6	2.2	-0.2	1.5	0.5	-0.0
Loneliness, isolation	0.5	0.7	1.1	-0.6	1.0	1.0	0.6
Long-standing illness, disability or infirmity	2.5	3.9	8.2	-1.3	-2.9	2.2	0.9
Ever had bowel cancer screening	3.7	4.3	6.0	-2.4	1.0	2.1	2.4
Diabetes diagnosed by doctor	0.6	1.0	3.5	0.4	-1.9	0.0	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	5.1	-0.2	-2.3	0.3	0.1
Friendships satisfaction	0.6	0.7	1.4	-0.7	0.9	1.2	0.3
Qualifications: nursing, teaching	0.5	0.8	2.1	-0.5	-0.9	1.4	-0.1
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.4	-0.1	0.1	0.6
Eye problems/disorders: Cataract	0.9	1.0	1.7	1.2	-0.5	-0.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.3	-1.1	0.6	0.8	0.9
Medication for cholesterol	1.5	2.2	5.0	1.0	2.2	-1.6	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	7.4	-0.1	2.7	0.2	0.2
Back pain experienced in last month	0.8	1.1	4.0	0.3	2.0	-0.6	-0.2
Mineral and other dietary supplements	0.3	0.4	0.5	0.6	0.6	-0.7	-0.7
Breast cancer (self-reported)	1.4	1.7	5.7	0.2	2.4	-0.9	0.1
Asthma (self-reported)	24.2	48.2	55.2	-7.4	-5.6	7.2	7.3
Osteoporosis (self-reported)	1.1	1.3	3.9	0.7	2.0	-0.6	-0.8
Osteoarthritis (self-reported)	1.5	1.9	4.8	-1.0	-2.2	1.1	0.8
Medication: Aspirin	0.7	0.9	2.8	0.6	-1.7	-0.3	-0.7
Medication: Gliclazide	0.4	0.5	1.5	0.3	-1.2	0.0	-0.5
Illnesses of father: None of the above (group 1)	1.1	1.3	5.3	0.0	2.3	-0.1	-0.0
Smoking status: Current	0.9	1.4	2.0	1.4	0.5	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	6.0	2.0	1.0	-2.4	-1.8
Whole body water mass	2.6	14.6	57.2	0.7	7.6	-0.3	-0.8
Leg predicted mass (right)	2.3	12.4	48.2	0.8	6.9	-0.2	-0.9
Arm fat mass (left)	0.1	0.4	0.5	-0.5	0.7	0.6	0.6
Number of self-reported non-cancer illnesses	5.5	9.6	11.5	-3.0	-3.1	3.4	2.8
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.3	0.5	0.1	0.0
Miserableness	2.0	3.5	5.2	-1.8	2.3	1.4	2.0
Guilty feelings	1.1	1.6	2.1	-1.4	0.9	1.2	1.5
Wears glasses or contact lenses	1.2	1.4	2.4	-1.4	-0.7	0.8	1.6
Ever taken oral contraceptive pill	0.6	0.7	2.3	0.1	-1.5	-0.5	-0.1
Hearing aid user	1.0	1.1	2.4	1.0	-0.7	-1.6	-0.6
Mother’s age at death	0.2	0.2	0.6	-0.2	-0.5	0.7	-0.0
Financial situation satisfaction	0.1	0.2	0.3	0.1	-0.6	0.3	-0.5
Tinnitus: Yes, now most or all of the time	3.2	3.8	5.0	-2.1	-1.7	1.7	2.2
Commuting to job workplace: Public transport	0.2	0.3	0.5	-0.4	0.7	-0.4	0.6
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	-0.5	-1.6	0.7	0.4
Medication: Blood pressure	1.9	3.6	11.4	-0.8	-3.4	1.5	0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.3	-0.7	1.5	0.3	0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.8	-0.7	-1.7	0.5	0.8
High cholesterol (Self-reported)	0.3	0.5	0.9	-0.8	0.6	0.4	1.0
Medication: Bendroflumethiazide	2.6	3.9	14.6	-0.2	-3.8	1.0	-0.2
Medication: Paracetamol	0.4	0.7	1.6	-0.6	1.3	0.5	0.7
Medication: Lisinopril	0.3	0.3	1.3	-0.0	-1.2	0.1	0.1
Medication: Atorvastatin	0.3	0.4	0.8	0.5	-0.9	-0.6	-0.5
Illnesses of father: High blood pressure	0.3	0.3	1.0	-0.4	-1.0	0.0	0.5
Alcohol drinker status: Never	0.1	0.1	0.2	0.0	0.2	0.5	-0.2
Ever smoked	0.3	0.5	2.1	-0.0	-1.4	0.0	0.0
Basal metabolic rate	2.3	12.5	48.9	0.6	7.0	-0.3	-0.7
Leg fat percentage (left)	1.3	4.6	13.4	-1.3	-3.7	1.2	1.4
Arm fat-free mass (left)	1.8	9.2	36.1	0.5	6.0	-0.2	-0.6
Number of operations (self-reported)	0.2	0.2	0.7	-0.1	0.8	0.5	0.0
Average weekly beer plus cider intake	2.3	3.3	4.1	1.7	1.9	-2.0	-1.6
Irritability	0.5	0.9	1.4	-0.8	1.0	1.2	0.7
Risk taking	0.4	0.6	0.9	0.8	-0.4	-0.9	-0.9
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.2	0.1	0.2	0.1
Fractured/broken bones in last 5 years	2.2	2.9	3.8	1.7	1.4	-1.7	-2.0
Age started oral contraceptive pill	0.4	0.4	0.8	0.8	-0.4	-0.4	-0.9
Diastolic blood pressure, automated reading	1.1	3.5	10.1	-1.3	-3.2	0.4	1.4
Ever depressed for a whole week	0.7	0.8	2.2	-0.9	-0.1	1.5	0.5
Unable to work because of sickness or disability	0.6	0.8	1.1	1.0	-0.8	-0.8	-1.0
Commuting to job workplace: Cycle	1.7	2.1	2.8	-1.4	1.2	1.4	1.7
Myopia	1.1	1.7	2.4	-1.5	-0.1	1.5	1.4
Vascular/heart problems diagnosed by doctor	2.2	6.0	23.1	-0.5	4.8	0.0	0.9
Cholesterol lowering medication	0.1	0.2	0.5	0.3	0.7	0.0	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	-0.2	-1.2	0.1	0.3
Pain experienced in last month	0.2	0.3	0.5	0.7	-0.6	-0.2	-0.7
Supplements: Calcium	0.6	0.7	2.4	-0.4	1.6	0.3	0.3
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	-0.4	1.1	0.6	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.6	0.2	-1.6	-0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	-0.3	-0.0	-0.4
Heart disease (siblings)	1.0	1.2	2.5	1.1	-0.2	-1.6	-1.0
Alcohol drinker status: Previous	1.2	1.4	1.9	1.3	0.2	-1.4	-1.4
Pack years of smoking	0.5	0.7	2.7	-0.2	1.6	0.1	0.3
Impedance of whole body	0.2	1.0	3.1	0.7	-0.4	-1.8	-0.2
Leg fat mass (left)	0.1	0.4	0.6	-0.7	-0.4	0.7	0.8
Arm predicted mass (left)	2.0	10.4	41.3	0.2	6.4	-0.1	-0.4