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chr10:103,527,782-105,647,095

Best TWAS P=3.5e-19 · Best GWAS P=7.25e-17 conditioned to 0.229

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	-5.5	-6.5	6.3e-11	-0.62	0.14	0.26	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARL3	0.03	0.03	lasso	6	0.03	1.8e-04	7.3	-8.1	7.8e-16	-0.91	0.02	0.97	FALSE
3	GTEx	Adipose Subcutaneous	TMEM180	0.24	0.16	enet	11	0.18	2.2e-14	7.5	6.2	4.4e-10	0.79	0.84	0.16	FALSE
4	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	8.3	-9.0	3.5e-19	-0.86	0.05	0.64	TRUE
5	GTEx	Adipose Visceral Omentum	TMEM180	0.24	0.18	enet	23	0.26	1.2e-13	7.5	5.5	3.5e-08	0.67	0.28	0.71	FALSE
6	GTEx	Adipose Visceral Omentum	WBP1L	0.08	0.00	enet	13	0.01	8.1e-02	-5.7	-6.3	2.3e-10	-0.65	0.07	0.51	FALSE
7	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	7.5	7.9	2.0e-15	0.81	0.11	0.84	FALSE
8	GTEx	Artery Aorta	TMEM180	0.25	0.23	enet	37	0.25	7.4e-14	7.6	5.7	1.1e-08	0.75	0.48	0.52	FALSE
9	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	7.6	7.4	1.1e-13	0.84	0.11	0.61	FALSE
10	GTEx	Artery Tibial	TMEM180	0.07	0.05	enet	14	0.03	3.8e-03	7.5	7.0	2.0e-12	0.85	0.16	0.83	FALSE
11	GTEx	Brain Cerebellar Hemisphere	TMEM180	0.23	0.23	lasso	10	0.10	1.3e-03	7.5	7.7	1.9e-14	0.93	0.03	0.96	FALSE
12	GTEx	Brain Cerebellum	TMEM180	0.25	0.29	enet	11	0.26	3.5e-08	7.5	7.8	5.3e-15	0.90	0.06	0.94	FALSE
13	GTEx	Brain Hypothalamus	TMEM180	0.21	0.20	lasso	5	0.12	8.5e-04	7.5	7.4	1.4e-13	0.91	0.04	0.85	FALSE
14	GTEx	Breast Mammary Tissue	TMEM180	0.17	0.16	enet	9	0.17	3.6e-09	7.5	7.9	2.8e-15	0.94	0.04	0.96	FALSE
15	GTEx	Breast Mammary Tissue (Male)	TMEM180	0.26	0.15	lasso	17	0.17	1.0e-04	7.5	6.8	1.1e-11	0.88	0.03	0.90	FALSE
16	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	6.0	-6.1	1.2e-09	-0.54	0.03	0.25	FALSE
17	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	8.2	8.6	7.6e-18	0.78	0.04	0.86	FALSE
18	GTEx	Breast Mammary Tissue (Female)	SFXN2	0.09	-0.01	enet	7	0.01	1.9e-01	1.0	-6.3	3.6e-10	-0.69	0.04	0.35	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	5.3	-5.2	2.3e-07	-0.59	0.20	0.65	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	7.4	-7.3	3.0e-13	-0.74	0.16	0.35	FALSE
21	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	7.3	-7.3	3.0e-13	-0.76	0.26	0.20	FALSE
22	GTEx	Colon Sigmoid	TMEM180	0.32	0.41	lasso	3	0.38	1.5e-14	7.5	7.7	1.0e-14	0.88	0.31	0.69	FALSE
23	GTEx	Colon Transverse	TMEM180	0.16	0.15	enet	11	0.13	1.2e-06	7.5	7.3	3.1e-13	0.88	0.36	0.63	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	TMEM180	0.22	0.23	enet	11	0.27	3.0e-10	7.5	6.9	6.2e-12	0.85	0.12	0.88	FALSE
25	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	7.8	7.4	1.4e-13	0.69	0.07	0.91	FALSE
26	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	7.5	8.1	5.1e-16	0.77	0.05	0.91	FALSE
27	GTEx	Esophagus Muscularis	TMEM180	0.23	0.22	enet	19	0.19	1.6e-11	7.5	7.7	1.1e-14	0.92	0.08	0.92	FALSE
28	GTEx	Heart Atrial Appendage	TMEM180	0.42	0.21	enet	35	0.27	2.1e-12	7.5	6.6	4.3e-11	0.67	0.66	0.33	FALSE
29	GTEx	Heart Left Ventricle	TMEM180	0.19	0.17	enet	14	0.17	3.7e-09	7.5	7.2	8.7e-13	0.90	0.08	0.92	FALSE
30	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	7.4	6.9	5.4e-12	0.65	0.20	0.76	FALSE
31	GTEx	Lung	TMEM180	0.12	0.11	lasso	4	0.13	5.1e-10	7.6	6.9	5.5e-12	0.88	0.04	0.96	FALSE
32	GTEx	Nerve Tibial	TMEM180	0.32	0.30	enet	16	0.32	2.0e-23	7.5	7.4	1.7e-13	0.89	0.64	0.36	FALSE
33	GTEx	Nerve Tibial	SFXN2	0.30	0.22	lasso	11	0.22	1.7e-15	-5.4	-5.8	7.1e-09	-0.53	1.00	0.00	FALSE
34	GTEx	Ovary	TMEM180	0.41	0.24	enet	18	0.23	2.4e-06	7.5	5.8	5.8e-09	0.74	0.17	0.76	FALSE
35	GTEx	Pancreas	SFXN2	0.66	0.32	enet	54	0.33	8.7e-15	1.3	-5.2	2.4e-07	-0.47	1.00	0.00	FALSE
36	GTEx	Pituitary	NT5C2	0.19	-0.01	lasso	10	0.01	1.8e-01	8.2	6.4	1.5e-10	0.80	0.02	0.68	FALSE
37	GTEx	Pituitary	TMEM180	0.36	0.23	enet	12	0.20	1.1e-05	7.5	6.8	1.4e-11	0.84	0.08	0.86	FALSE
38	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	7.4	-7.3	2.8e-13	-0.76	0.60	0.38	FALSE
39	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	7.3	-6.2	4.7e-10	-0.65	0.64	0.30	FALSE
40	GTEx	Spleen	TMEM180	0.16	0.21	lasso	3	0.05	2.6e-02	7.5	7.0	2.8e-12	0.89	0.05	0.78	FALSE
41	GTEx	Stomach	TMEM180	0.33	0.22	lasso	8	0.21	2.2e-10	7.5	6.7	1.8e-11	0.85	0.54	0.46	FALSE
42	GTEx	Testis	TMEM180	0.19	0.05	enet	24	0.12	7.9e-06	7.5	7.0	1.8e-12	0.71	0.06	0.94	FALSE
43	GTEx	Thyroid	C10orf95	0.10	0.02	enet	28	0.02	6.6e-03	7.5	6.9	6.9e-12	0.66	0.08	0.64	FALSE
44	GTEx	Thyroid	TMEM180	0.31	0.38	enet	20	0.42	8.1e-35	7.5	6.6	3.7e-11	0.87	0.70	0.30	FALSE
45	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	7.6	6.8	1.3e-11	0.64	0.04	0.44	FALSE
46	GTEx	Whole Blood	TMEM180	0.24	0.01	enet	44	0.00	1.4e-01	7.5	5.8	7.5e-09	0.61	0.20	0.28	FALSE
47	METSIM	Adipose	TMEM180	0.28	0.25	enet	33	0.26	2.5e-39	7.5	7.1	1.4e-12	0.86	0.85	0.15	FALSE
48	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	7.5	-7.9	2.2e-15	-0.83	0.61	0.39	FALSE
49	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	7.5	-7.6	2.0e-14	-0.80	0.04	0.96	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	TRIM8	0.09	0.03	enet	25	0.06	3.7e-08	-3.2	-6.2	7.2e-10	-0.75	0.20	0.80	FALSE
51	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	8.3	-8.4	4.3e-17	-0.91	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	6.0	6.5	8.5e-11	0.61	0.13	0.86	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	-0.9	-5.8	6.8e-09	-0.69	0.02	0.73	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACTR1A	0.02	0.02	lasso	5	0.02	4.6e-03	7.5	-7.6	2.4e-14	-0.88	0.02	0.80	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARL3	0.02	0.00	blup	57	0.01	8.3e-03	-5.7	-5.1	2.7e-07	-0.66	0.02	0.37	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM180	0.03	0.03	blup	52	0.04	3.9e-05	7.3	-6.9	3.8e-12	-0.79	0.03	0.95	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARL3	0.04	0.00	blup	57	0.04	1.5e-05	1.9	-5.7	1.0e-08	-0.72	0.03	0.88	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUFU	0.03	0.03	lasso	1	0.03	2.0e-04	7.5	7.5	8.3e-14	0.91	0.15	0.82	FALSE
59	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ARL3	0.04	0.00	blup	57	0.02	3.1e-03	2.2	-5.3	1.5e-07	-0.67	0.06	0.47	FALSE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	7.3	8.3	7.3e-17	0.90	0.04	0.66	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL3	0.04	0.02	blup	57	0.03	9.2e-04	1.9	-5.4	7.2e-08	-0.73	0.08	0.38	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf95	0.02	0.03	lasso	2	0.02	4.7e-03	7.6	7.7	1.6e-14	0.87	0.01	0.92	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	7.4	7.5	5.3e-14	0.73	0.03	0.97	FALSE