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chr11:64,669,105-66,690,454

Best TWAS P=6.65e-17 · Best GWAS P=2.53e-23 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CFL1	0.04	0.00	bslmm	350	0.02	3.3e-03	-4.6	6.0	1.5e-09	-0.40	0.11	0.07	FALSE
2	GTEx	Adipose Visceral Omentum	MAP3K11	0.08	0.08	lasso	4	0.05	1.7e-03	6.8	7.1	1.7e-12	-0.58	0.48	0.09	FALSE
3	GTEx	Artery Aorta	MAP3K11	0.15	0.15	lasso	4	0.13	1.8e-07	6.0	5.7	1.5e-08	-0.45	1.00	0.00	FALSE
4	GTEx	Artery Aorta	SART1	0.08	0.00	enet	23	0.00	2.1e-01	-5.3	5.7	1.4e-08	-0.43	0.07	0.20	FALSE
5	GTEx	Artery Tibial	EFEMP2	0.11	0.07	lasso	8	0.05	1.3e-04	8.1	-7.4	1.1e-13	0.53	0.85	0.10	FALSE
6	GTEx	Artery Tibial	BANF1	0.05	0.05	lasso	5	0.06	3.4e-05	-7.1	7.1	1.4e-12	-0.48	0.46	0.04	FALSE
7	GTEx	Artery Tibial	EIF1AD	0.11	0.00	enet	26	0.01	9.4e-02	8.1	-5.4	5.3e-08	0.48	0.08	0.16	TRUE
8	GTEx	Brain Cerebellar Hemisphere	EFEMP2	0.35	0.15	enet	5	0.09	2.2e-03	-7.0	-6.7	1.8e-11	0.48	0.33	0.09	TRUE
9	GTEx	Brain Cerebellum	EFEMP2	0.45	0.40	enet	8	0.39	1.6e-12	-6.6	-6.1	8.0e-10	0.46	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue	FIBP	0.07	0.00	lasso	4	0.01	9.7e-02	3.6	-6.3	2.4e-10	0.50	0.08	0.43	FALSE
11	GTEx	Breast Mammary Tissue (Male)	MAP3K11	0.23	0.09	lasso	4	0.02	1.4e-01	4.8	5.4	6.4e-08	-0.44	0.09	0.10	FALSE
12	GTEx	Cells Transformed fibroblasts	EFEMP2	0.06	0.06	lasso	3	0.07	7.8e-06	-5.8	-5.3	1.0e-07	0.40	0.78	0.04	FALSE
13	GTEx	Cells Transformed fibroblasts	EIF1AD	0.28	0.20	lasso	8	0.21	1.8e-15	-5.5	-6.2	7.1e-10	0.41	1.00	0.00	FALSE
14	GTEx	Colon Sigmoid	CTSW	0.11	0.06	lasso	3	0.07	1.4e-03	-6.6	6.8	1.0e-11	-0.47	0.24	0.04	FALSE
15	GTEx	Colon Sigmoid	MAP3K11	0.23	0.05	enet	8	0.08	6.5e-04	6.0	6.6	4.9e-11	-0.58	0.37	0.42	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	MAP3K11	0.31	0.27	enet	42	0.26	4.9e-10	4.3	5.3	1.5e-07	-0.27	0.97	0.01	FALSE
17	GTEx	Esophagus Mucosa	EIF1AD	0.15	0.12	lasso	4	0.10	3.2e-07	-6.0	-6.0	2.7e-09	0.40	0.99	0.00	FALSE
18	GTEx	Esophagus Muscularis	EIF1AD	0.26	0.03	enet	50	0.10	6.6e-07	-5.5	-5.4	6.3e-08	0.33	0.34	0.10	FALSE
19	GTEx	Esophagus Muscularis	AP001266.1	0.11	0.01	enet	17	0.03	6.1e-03	4.0	5.7	1.3e-08	-0.39	0.14	0.27	FALSE
20	GTEx	Lung	CFL1	0.04	0.02	lasso	10	0.01	5.8e-02	-5.5	6.1	1.2e-09	-0.40	0.38	0.02	TRUE
21	GTEx	Skin Sun Exposed Lower leg	EIF1AD	0.08	0.07	lasso	4	0.07	3.6e-06	4.7	-6.2	5.8e-10	0.41	0.98	0.00	FALSE
22	GTEx	Stomach	MAP3K11	0.09	0.02	lasso	3	0.04	4.4e-03	4.3	6.5	1.0e-10	-0.47	0.20	0.06	FALSE
23	GTEx	Thyroid	PACS1	0.09	0.04	enet	16	0.09	2.8e-07	5.5	6.5	6.3e-11	-0.34	0.76	0.04	FALSE
24	GTEx	Thyroid	BANF1	0.10	0.05	enet	17	0.06	4.5e-05	-5.5	5.9	3.9e-09	-0.34	0.99	0.00	FALSE
25	GTEx	Thyroid	PCNXL3	0.07	0.05	lasso	4	0.03	2.2e-03	6.0	5.9	4.2e-09	-0.48	0.39	0.06	TRUE
26	METSIM	Adipose	BANF1	0.10	0.06	bslmm	343	0.07	4.9e-10	-5.5	5.4	7.3e-08	-0.32	1.00	0.00	FALSE
27	METSIM	Adipose	EFEMP2	0.07	0.05	lasso	8	0.04	4.2e-06	-8.1	-8.2	1.8e-16	0.50	1.00	0.00	FALSE
28	NTR	Blood	BANF1	0.03	0.00	enet	10	0.02	1.1e-06	4.7	5.3	1.0e-07	-0.36	0.18	0.06	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	EFEMP2	0.08	0.09	enet	13	0.09	6.8e-12	7.5	-7.0	2.2e-12	0.49	1.00	0.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	OVOL1	0.16	0.24	lasso	2	0.24	1.3e-30	6.8	6.7	1.6e-11	-0.61	1.00	0.00	FALSE
31	YFS	Blood	EFEMP2	0.12	0.07	bslmm	348	0.13	4.3e-41	-7.1	-7.0	2.7e-12	0.36	1.00	0.00	TRUE
32	YFS	Blood	MUS81	0.04	0.02	blup	348	0.04	6.3e-12	-6.6	7.0	1.9e-12	-0.47	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP2	0.04	0.02	lasso	5	0.02	1.4e-05	-7.4	-7.3	2.0e-13	0.47	0.09	0.90	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	FIBP	0.03	0.03	blup	45	0.03	2.6e-07	-7.4	-5.7	1.4e-08	0.42	0.28	0.72	FALSE
35	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	EIF1AD	0.07	0.07	enet	5	0.05	1.5e-03	-5.5	-5.6	2.3e-08	0.35	0.01	0.96	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	DKFZp761E198	0.14	0.00	blup	39	0.05	1.4e-02	4.0	6.0	2.5e-09	-0.58	0.01	0.24	TRUE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	SNX32	0.13	0.05	blup	60	0.09	1.1e-03	-1.4	-5.1	2.9e-07	0.41	0.13	0.06	TRUE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BANF1	0.03	0.04	lasso	4	0.03	1.4e-04	-6.0	5.9	3.1e-09	-0.38	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EIF1AD	0.03	0.02	blup	42	0.02	1.5e-03	-5.5	-6.0	1.5e-09	0.35	0.01	0.94	TRUE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DKFZp761E198	0.11	0.02	blup	39	0.03	4.6e-03	-5.9	-6.4	1.2e-10	0.47	0.05	0.21	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EIF1AD	0.06	0.04	lasso	3	0.05	1.3e-03	-5.6	-6.0	2.5e-09	0.38	0.01	0.98	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf68	0.03	0.03	lasso	3	0.03	1.1e-04	-5.3	6.3	3.4e-10	-0.37	0.01	0.91	TRUE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	DKFZp761E198	0.09	0.06	lasso	3	0.07	2.3e-08	4.0	5.3	1.4e-07	-0.58	0.69	0.29	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	OVOL1	0.03	0.03	blup	36	0.02	8.3e-04	6.8	8.4	6.6e-17	-0.74	0.03	0.82	TRUE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	BANF1	0.03	0.00	blup	44	0.02	3.9e-03	-6.0	5.4	6.9e-08	-0.29	0.01	0.76	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF1AD	0.03	0.00	blup	42	0.01	2.5e-02	-2.1	-5.2	2.2e-07	0.30	0.01	0.49	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EIF1AD	0.11	0.15	enet	14	0.14	2.9e-06	-6.0	-5.9	3.5e-09	0.40	0.00	0.99	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SNX32	0.40	0.17	blup	60	0.22	1.3e-09	-3.1	-5.4	5.4e-08	0.35	0.98	0.00	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DRAP1	0.09	0.10	enet	12	0.09	1.8e-04	-6.0	5.6	1.7e-08	-0.41	0.05	0.34	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	EIF1AD	0.08	0.10	enet	3	0.09	6.0e-10	-6.0	-6.0	2.3e-09	0.39	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	EIF1AD	0.05	0.06	blup	42	0.02	1.3e-02	-5.4	-5.6	2.0e-08	0.37	0.01	0.94	FALSE
52	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RNASEH2C	0.10	0.01	blup	32	0.05	7.9e-03	-3.7	-6.4	1.4e-10	0.57	0.01	0.26	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	DKFZp761E198	0.06	0.05	blup	39	0.05	3.0e-05	4.0	5.9	4.7e-09	-0.56	0.26	0.41	FALSE