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chr17:36,710,513-39,048,774

Best TWAS P=3.68e-19 · Best GWAS P=5.06e-19 conditioned to 0.0127

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Heart Atrial Appendage	PNMT	0.14	-0.01	lasso	8	0.00	5.3e-01	8.34	-8.9	3.7e-19	-0.85	0.09	0.58	TRUE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMB	0.14	0.16	lasso	4	0.14	2.4e-06	8.82	-8.2	1.6e-16	-0.99	0.00	0.99	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	8.91	-8.1	3.7e-16	-0.95	0.01	0.99	FALSE
42	NTR	Blood	ORMDL3	0.10	0.10	enet	24	0.12	4.4e-36	8.82	-8.1	3.8e-16	-0.91	0.01	0.99	FALSE
44	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	-7.98	-8.1	8.2e-16	-0.88	0.89	0.11	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	7.88	-8.1	8.3e-16	-0.93	0.02	0.91	FALSE
43	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	-7.98	-8.0	1.3e-15	-0.91	0.88	0.12	FALSE
35	GTEx	Whole Blood	GSDMB	0.15	0.10	lasso	4	0.10	4.5e-09	-7.68	-7.9	2.6e-15	-0.94	0.12	0.88	FALSE
40	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	-7.04	-7.9	3.0e-15	-0.88	0.77	0.23	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	8.91	-7.7	1.0e-14	-0.94	0.01	0.83	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	8.34	7.7	1.2e-14	0.87	0.05	0.61	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMB	0.02	0.01	blup	39	0.01	1.5e-02	-6.06	-7.7	1.4e-14	-0.97	0.02	0.82	FALSE
14	GTEx	Heart Atrial Appendage	ERBB2	0.13	0.04	enet	18	0.02	4.8e-02	-5.80	-7.7	1.5e-14	-0.66	0.09	0.69	FALSE
29	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	-6.48	-7.6	2.2e-14	-0.77	0.08	0.80	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ORMDL3	0.03	0.04	lasso	2	0.04	2.9e-05	8.60	-7.6	3.3e-14	-0.96	0.04	0.96	FALSE
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	-6.19	-7.4	1.1e-13	-0.95	0.02	0.97	FALSE
36	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	-6.24	-7.4	1.7e-13	-0.93	0.03	0.97	FALSE
41	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	8.23	7.2	8.7e-13	0.89	0.02	0.98	FALSE
33	GTEx	Thyroid	PGAP3	0.19	0.21	lasso	10	0.24	3.5e-18	-6.61	-7.1	1.7e-12	-0.61	1.00	0.00	FALSE
13	GTEx	Heart Atrial Appendage	PPP1R1B	0.09	0.04	enet	10	0.08	2.2e-04	-5.71	-7.0	2.2e-12	-0.74	0.21	0.63	FALSE
17	GTEx	Liver	PGAP3	0.27	0.17	lasso	4	0.13	1.7e-04	-6.10	-7.0	2.2e-12	-0.59	0.44	0.39	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	ORMDL3	0.08	0.13	blup	37	0.15	3.8e-14	-6.24	-6.9	3.8e-12	-0.90	0.64	0.36	FALSE
87	The Cancer Genome Atlas	Skin Cutaneous Melanoma	GSDMA	0.23	0.16	blup	47	0.18	1.3e-05	-5.79	6.9	4.7e-12	0.61	0.03	0.89	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMB	0.05	0.07	blup	39	0.05	1.4e-06	-6.06	-6.9	5.8e-12	-0.86	0.49	0.51	FALSE
31	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	-6.37	-6.8	8.6e-12	-0.87	0.57	0.42	FALSE
8	GTEx	Colon Transverse	GSDMB	0.14	0.11	enet	18	0.12	2.0e-06	8.43	-6.8	9.0e-12	-0.91	0.07	0.93	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMB	0.06	0.05	enet	7	0.05	2.2e-06	-6.45	-6.8	1.3e-11	-0.87	0.47	0.50	FALSE
81	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PGAP3	0.17	0.13	blup	41	0.10	6.8e-05	-6.57	-6.8	1.4e-11	-0.58	0.01	0.98	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZPBP2	0.08	0.09	enet	5	0.10	6.1e-08	-7.87	6.8	1.4e-11	0.89	0.41	0.58	FALSE
32	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	-6.37	-6.7	1.9e-11	-0.88	0.48	0.52	FALSE
24	GTEx	Pancreas	PGAP3	0.37	0.25	lasso	6	0.21	1.9e-09	-6.10	-6.7	2.5e-11	-0.61	0.86	0.13	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	PGAP3	0.06	0.06	lasso	4	0.06	4.5e-07	-6.57	-6.6	3.9e-11	-0.55	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	-6.45	-6.5	5.8e-11	-0.84	0.10	0.90	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMA	0.19	0.21	lasso	4	0.24	5.5e-23	-5.79	6.5	6.8e-11	0.54	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GSDMA	0.66	0.48	enet	21	0.51	1.2e-65	-5.79	6.4	1.2e-10	0.49	1.00	0.00	FALSE
10	GTEx	Esophagus Mucosa	GSDMB	0.06	0.04	lasso	3	0.03	4.7e-03	-5.51	-6.4	1.4e-10	-0.69	0.17	0.37	FALSE
12	GTEx	Esophagus Muscularis	PGAP3	0.11	0.08	enet	10	0.10	1.1e-06	-5.62	-6.4	2.0e-10	-0.58	0.81	0.17	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	STARD3	0.10	0.06	lasso	5	0.05	2.6e-05	-6.47	-6.3	2.2e-10	-0.50	0.01	0.99	FALSE
22	GTEx	Nerve Tibial	ERBB2	0.08	0.08	lasso	5	0.07	1.3e-05	-6.49	-6.3	2.6e-10	-0.52	0.97	0.01	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	TCAP	0.07	0.02	enet	7	0.01	1.2e-01	-6.49	-6.3	2.9e-10	-0.51	0.09	0.43	FALSE
16	GTEx	Heart Atrial Appendage	PGAP3	0.13	0.16	lasso	3	0.18	2.6e-08	-6.49	-6.3	3.2e-10	-0.53	0.98	0.01	FALSE
54	The Cancer Genome Atlas	Glioblastoma Multiforme	GSDMA	0.58	0.33	enet	10	0.34	5.3e-11	-5.79	6.3	3.6e-10	0.47	0.99	0.00	FALSE
66	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GSDMA	0.41	0.37	lasso	2	0.38	3.7e-19	-5.79	6.3	3.6e-10	0.54	1.00	0.00	FALSE
26	GTEx	Prostate	PGAP3	0.23	0.03	enet	26	0.06	1.6e-02	-5.60	-6.3	3.7e-10	-0.53	0.15	0.41	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	GSDMA	0.61	0.49	lasso	5	0.51	5.0e-124	-5.79	6.2	5.0e-10	0.50	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PGAP3	0.16	0.16	enet	14	0.15	5.1e-09	-6.10	-6.2	5.6e-10	-0.49	0.07	0.93	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GSDMA	0.05	0.06	lasso	4	0.05	7.8e-05	-5.79	6.2	6.0e-10	0.54	0.21	0.24	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STARD3	0.03	0.03	enet	8	0.04	6.6e-05	-6.48	-6.2	6.2e-10	-0.51	0.01	0.98	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	PGAP3	0.05	0.08	lasso	10	0.08	2.1e-09	-6.10	-6.2	6.9e-10	-0.53	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMA	0.65	0.56	lasso	4	0.58	1.5e-81	-5.79	6.2	7.5e-10	0.49	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	PGAP3	0.18	0.26	enet	12	0.28	5.7e-30	-6.10	-6.1	8.4e-10	-0.53	0.06	0.94	FALSE
77	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GSDMA	0.50	0.37	enet	15	0.43	4.2e-31	-5.79	6.1	8.8e-10	0.45	1.00	0.00	FALSE
92	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GSDMA	0.38	0.32	enet	7	0.32	5.9e-12	-5.79	6.1	9.5e-10	0.50	0.99	0.00	FALSE
80	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GSDMA	0.52	0.34	lasso	4	0.36	5.1e-15	-5.79	6.1	9.6e-10	0.46	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PGAP3	0.04	0.08	lasso	1	0.07	1.5e-08	-6.10	-6.1	1.1e-09	-0.52	0.04	0.96	FALSE
18	GTEx	Lung	GSDMB	0.07	0.07	lasso	4	0.05	1.5e-04	-6.24	-6.1	1.2e-09	-0.81	0.42	0.30	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PGAP3	0.06	0.10	lasso	2	0.09	1.5e-10	-6.10	-6.1	1.2e-09	-0.52	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMA	0.15	0.19	enet	9	0.19	1.7e-21	-5.79	6.1	1.3e-09	0.55	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	GSDMA	0.16	0.12	lasso	2	0.12	1.1e-12	-5.79	6.1	1.4e-09	0.48	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PGAP3	0.07	0.12	blup	37	0.11	1.2e-09	-5.53	-6.0	2.2e-09	-0.54	0.14	0.86	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	PGAP3	0.05	0.05	lasso	4	0.05	1.0e-04	-6.45	-5.9	2.9e-09	-0.54	0.02	0.96	FALSE
2	GTEx	Adipose Visceral Omentum	PGAP3	0.12	0.11	lasso	6	0.10	7.1e-06	-5.60	-5.9	3.3e-09	-0.54	0.92	0.06	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	PGAP3	0.10	0.17	blup	37	0.17	6.4e-10	-6.10	-5.9	3.9e-09	-0.56	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Glioblastoma Multiforme	PGAP3	0.19	0.13	blup	37	0.16	1.5e-05	-6.10	-5.9	4.0e-09	-0.53	0.02	0.96	FALSE
37	METSIM	Adipose	GSDMA	0.14	0.16	lasso	7	0.17	2.6e-24	-5.51	5.9	4.6e-09	0.60	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GSDMA	0.08	0.03	enet	10	0.08	9.7e-05	-5.79	5.9	4.7e-09	0.36	0.06	0.27	FALSE
86	The Cancer Genome Atlas	Soft Tissue Sarcoma	GSDMA	0.44	0.45	lasso	4	0.44	3.2e-28	-5.79	5.8	5.3e-09	0.51	1.00	0.00	FALSE
19	GTEx	Lung	PGAP3	0.24	0.14	lasso	7	0.12	2.3e-09	-5.60	-5.8	6.4e-09	-0.51	1.00	0.00	FALSE
25	GTEx	Pituitary	PGAP3	0.15	0.22	lasso	2	0.19	1.8e-05	-5.80	-5.8	6.4e-09	-0.51	0.28	0.20	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	PGAP3	0.10	0.16	lasso	5	0.17	1.4e-16	-6.10	-5.8	6.6e-09	-0.51	0.05	0.95	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GSDMA	0.37	0.44	lasso	1	0.44	3.3e-27	-5.79	5.8	6.9e-09	0.50	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	PGAP3	0.08	0.07	blup	41	0.08	2.7e-16	-6.10	-5.8	8.3e-09	-0.52	0.20	0.80	FALSE
20	GTEx	Lung	ORMDL3	0.16	0.13	enet	15	0.14	1.6e-10	-7.68	-5.8	8.4e-09	-0.75	0.99	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PNMT	0.05	0.00	bslmm	327	0.00	8.2e-02	-3.86	5.8	8.6e-09	0.45	0.06	0.06	FALSE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMA	0.23	0.29	enet	6	0.24	2.8e-10	-5.79	5.7	1.0e-08	0.49	0.99	0.01	FALSE
4	GTEx	Artery Coronary	PGAP3	0.16	0.10	lasso	4	0.06	5.9e-03	-5.76	-5.7	1.2e-08	-0.51	0.18	0.25	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf37	0.04	0.01	enet	3	0.01	2.3e-02	-2.09	5.7	1.2e-08	0.62	0.01	0.51	FALSE
85	The Cancer Genome Atlas	Rectum Adenocarcinoma	PGAP3	0.20	0.14	blup	38	0.16	1.4e-04	-5.51	-5.7	1.2e-08	-0.59	0.03	0.59	FALSE
51	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PGAP3	0.04	0.01	blup	41	0.01	1.2e-01	-5.53	-5.7	1.5e-08	-0.54	0.02	0.62	FALSE
67	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PGAP3	0.09	0.11	lasso	4	0.11	5.9e-06	-5.51	-5.6	1.6e-08	-0.54	0.08	0.90	FALSE
38	METSIM	Adipose	PGAP3	0.06	0.05	lasso	4	0.05	8.8e-08	-6.10	-5.6	1.7e-08	-0.50	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMA	0.30	0.35	lasso	4	0.35	6.3e-43	-5.79	5.6	1.8e-08	0.46	1.00	0.00	FALSE
11	GTEx	Esophagus Mucosa	ORMDL3	0.09	0.01	enet	20	0.00	1.8e-01	-6.30	-5.6	2.1e-08	-0.53	0.11	0.07	FALSE
6	GTEx	Breast Mammary Tissue	ORMDL3	0.17	0.04	enet	27	0.06	7.2e-04	5.77	5.6	2.8e-08	0.78	0.03	0.93	FALSE
9	GTEx	Colon Transverse	PGAP3	0.24	0.20	enet	19	0.20	8.3e-10	-5.62	-5.5	3.6e-08	-0.50	0.99	0.01	FALSE
88	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMA	0.22	0.09	enet	9	0.13	2.3e-09	-5.79	5.5	3.6e-08	0.34	1.00	0.00	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	PGAP3	0.22	0.09	enet	33	0.14	3.4e-08	-5.62	-5.5	3.9e-08	-0.46	0.99	0.01	FALSE
30	GTEx	Skin Sun Exposed Lower leg	PGAP3	0.14	0.10	lasso	6	0.07	1.1e-06	-6.10	-5.5	3.9e-08	-0.48	0.98	0.02	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	STARD3	0.05	0.02	blup	50	0.02	1.1e-03	-6.57	-5.4	5.3e-08	-0.38	0.01	0.93	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	PNMT	0.03	0.05	lasso	4	0.04	6.2e-05	-5.00	-5.4	5.6e-08	-0.53	0.04	0.93	FALSE
34	GTEx	Thyroid	RP11-690G19.3	0.04	0.03	enet	6	0.02	1.5e-02	-4.92	5.4	5.8e-08	0.53	0.12	0.65	FALSE
7	GTEx	Cells Transformed fibroblasts	STARD3	0.08	0.01	enet	18	0.01	3.3e-02	-4.53	-5.4	6.3e-08	-0.36	0.30	0.14	FALSE
39	METSIM	Adipose	RP11-387H17.4	0.04	0.00	bslmm	286	0.01	8.4e-03	-0.76	5.4	6.8e-08	0.71	0.03	0.70	FALSE
3	GTEx	Adrenal Gland	PGAP3	0.17	0.14	lasso	2	0.12	3.2e-05	-4.53	-5.4	7.5e-08	-0.48	0.51	0.18	FALSE
45	YFS	Blood	PGAP3	0.08	0.12	lasso	11	0.12	1.7e-35	-5.54	-5.3	1.0e-07	-0.52	1.00	0.00	FALSE
23	GTEx	Nerve Tibial	PGAP3	0.19	0.11	lasso	5	0.12	1.1e-08	-5.53	-5.2	1.8e-07	-0.47	1.00	0.00	FALSE
93	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PGAP3	0.23	0.22	blup	38	0.24	3.6e-09	-4.55	-5.2	2.0e-07	-0.49	0.22	0.78	FALSE
21	GTEx	Muscle Skeletal	PGAP3	0.04	0.03	lasso	5	0.04	1.3e-04	-5.62	-5.1	3.0e-07	-0.52	0.62	0.08	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PGAP3	0.12	0.12	lasso	4	0.13	5.3e-14	-6.10	-5.1	3.0e-07	-0.50	0.12	0.88	FALSE