TWAS hub - MYRF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.2310	0.0880	6.1e-03	-0.002	NA	-0.007	NA	-0.005	3.6e-01	NA	5.4e-01	NA	4.6e-01
2	GTEx	Whole Blood	0.1680	0.0520	6.4e-04	0.033	NA	0.033	NA	0.037	4.3e-04	NA	4.5e-04	NA	2.4e-04
3	METSIM	Adipose	0.0833	0.0274	5.1e-05	0.064	0.036	0.042	0.054	0.060	8.2e-10	3.1e-06	5.3e-07	1.5e-08	2.4e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Major Depression (MDD)	8.1	9.9	11.0	3.1	3.0	3.3
Schizophrenia vs Biploar Disorder	7.9	10.5	12.1	-3.2	-3.0	-3.5
LDL Cholesterol	7.6	12.0	31.7	-5.6	-0.9	-1.9
Bipolar Disorder (2011)	6.6	6.3	6.6	2.6	2.5	2.5
Pulse rate	6.5	10.9	15.5	3.9	2.1	3.6
Hearing aid user	6.4	7.3	8.5	-2.9	-2.4	-2.7
Ever depressed for a whole week	6.1	7.5	10.3	2.5	2.4	3.2
Headache pain in last month	6.0	10.3	14.7	-1.4	-3.8	-3.8
Pulse rate, automated reading	5.9	18.9	36.6	6.0	1.9	4.1
Blood Red Count	5.8	55.9	72.6	8.5	5.5	8.1
Family relationship satisfaction	5.8	7.1	7.8	2.8	2.8	2.4
Fractured/broken bones in last 5 years	5.4	7.0	8.3	-2.9	-2.6	-2.4
Illness, injury, bereavement, stress in last 2 years	5.3	6.5	10.2	1.7	2.6	3.2
Blood Eosinophil Count	5.1	39.3	54.8	-7.4	-5.1	-6.1
Ulcerative Colitis (UC)	4.9	9.2	12.3	3.5	2.8	2.7
Fasting Glucose	4.9	5.8	11.0	-3.3	-1.5	-2.0
Type 2 Diabetes (T2D) (2012)	4.9	5.6	8.5	-2.9	-1.7	-2.3
Qualifications: NVQ or HND or HNC or equivalent	4.9	5.9	7.3	-1.9	-2.6	-2.7
Neuroticism	4.6	11.1	13.0	2.9	3.6	3.5
Bipolar Disorder (2018)	4.5	7.2	9.5	3.1	2.5	2.4
Breastfed as a baby	4.4	5.4	8.0	1.3	2.8	2.6
HDL Cholesterol	4.3	7.3	16.8	-4.1	0.3	-2.2
Blood White Count	4.2	31.3	39.6	-6.3	-5.2	-5.2
Knee pain experienced in last month	4.2	6.6	7.9	-2.0	-2.8	-2.8
Irritability	4.2	7.1	8.4	2.9	2.2	2.9
Triglycerides	4.1	6.7	9.8	3.1	0.9	3.1
Blood Platelet Count	4.1	48.0	75.7	8.7	4.5	6.9
Ulcerative Colitis	4.0	5.8	6.4	2.3	2.4	2.5
Wheeze or whistling in the chest in last year	4.0	7.1	9.0	-2.2	-2.8	-3.0
Medication: Lisinopril	4.0	5.2	6.1	2.1	2.5	2.2
Neuroticism score	3.9	8.2	9.2	2.6	2.9	3.0
Bipolar Disorder or Schizophrenia	3.8	9.3	12.9	3.6	2.8	2.7
Irritable Bowel Disease (IBD)	3.7	8.8	10.6	3.3	2.4	3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	7.9	1.9	2.3	2.8
Hypothyroidism (self reported)	3.5	8.1	14.8	-3.9	-1.8	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	3.5	4.6	9.6	3.1	1.4	1.5
Heart attack	3.4	4.3	9.2	-3.0	-1.2	-1.5
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	5.4	2.3	1.2	2.3
Average weekly champagne plus white wine intake	3.3	4.5	8.8	3.0	1.1	1.9
Miserableness	3.3	5.7	6.0	2.4	2.4	2.4
Myopia	3.3	4.8	6.6	1.8	2.2	2.6
Heart attack/myocardial infarction (self-reported)	3.3	4.3	9.2	-3.0	-1.2	-1.5
Neuroticism (2016)	3.2	4.6	5.6	1.6	2.4	2.3
Smoking status: Current	3.2	5.1	6.6	-2.6	-2.4	-1.7
Neuroticism (Nagel 2018)	3.1	7.3	10.7	1.3	3.3	3.1
Falls in the last year	3.1	4.2	7.3	-2.7	-1.3	-1.9
Exposure to tobacco smoke at home	3.1	3.5	6.6	-2.6	-1.3	-1.5
Hair/balding pattern: Pattern 4	3.1	7.5	11.4	-3.4	-1.8	-2.8
Other serious medical condition/disability diagnosed by doctor	3.0	3.8	6.9	-2.6	-1.9	-1.0
Blood clot in the leg (DVT)	3.0	3.9	8.8	-3.0	-1.3	-1.2
Relative age voice broke	2.9	4.4	4.8	2.2	2.0	2.0
Tense / ‘highly strung’	2.9	4.8	6.9	1.6	2.6	2.3
Supplements: Fish oil (including cod liver oil)	2.8	3.6	7.6	-2.8	-0.9	-1.6
Current tobacco smoking	2.7	4.5	5.7	-2.3	-2.4	-1.6
Frequency of depressed mood in last 2 weeks	2.6	3.7	6.6	2.6	1.6	1.4
Age started oral contraceptive pill	2.5	3.2	4.8	0.4	2.2	2.1
Townsend deprivation index at recruitment	2.4	3.4	6.9	2.6	1.5	1.1
Number of incorrect matches in round	2.4	3.9	7.4	1.2	2.7	1.7
Nervous feelings	2.4	4.5	5.1	2.3	2.0	2.1
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	8.1	-2.8	-0.9	-0.7
Alcohol usually taken with meals	2.3	3.8	4.0	1.9	2.0	1.9
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.5	4.2	1.6	2.1	1.9
Comparative body size at age 10	2.3	6.4	11.3	-0.9	-3.4	-2.6
Body Mass Index (BMI) (2010)	2.2	3.0	4.7	-0.9	-2.2	-1.8
Respiratory disease	2.2	5.0	7.2	-2.7	-1.6	-2.3
Worrier / anxious feelings	2.2	4.2	8.2	0.6	2.0	2.9
Number of live births	2.2	3.1	6.8	-2.6	-1.0	-1.3
Exposure to tobacco smoke outside home	2.2	3.0	5.4	-2.3	-1.4	-1.3
Overall health rating	2.2	4.8	6.8	-1.9	-2.6	-2.0
Depressed Affect (Nagel 2018)	2.1	4.5	6.6	0.9	2.6	2.5
HbA1C	2.1	2.3	4.0	-1.2	-1.2	-2.0
Fluid intelligence score	2.1	4.4	5.8	2.1	1.7	2.4
Medication for pain relief, constipation, heartburn	2.1	3.6	5.1	2.2	1.9	1.5
Asthma (self-reported)	2.1	4.1	5.4	-2.2	-1.5	-2.3
Schizophrenia (2014)	2.0	4.3	6.6	2.6	1.8	1.8
Asthma	2.0	3.9	5.2	-2.1	-1.5	-2.3
Had major operations	2.0	2.3	3.4	1.6	1.1	1.8
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.5	1.0	1.9	1.5
Glaucoma (self-reported)	1.9	2.2	2.8	-1.2	-1.5	-1.7
Shortness of breath walking on level ground	1.9	2.3	5.1	-2.2	-1.2	-0.4
Ever had bowel cancer screening	1.9	2.3	4.4	-2.1	-1.1	-1.0
Cholesterol lowering medication	1.9	2.8	6.0	-2.4	-0.9	-1.3
Medication: Levothyroxine sodium	1.8	3.0	4.4	-2.1	-1.1	-1.9
Happiness	1.8	2.2	4.1	2.0	1.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	2.3	-1.5	-1.4	-1.5
Depression (self-reported)	1.8	2.2	3.7	0.7	1.6	1.9
Lung cancer (father)	1.8	2.1	5.3	-2.3	-0.9	-0.3
Supplements: Calcium	1.8	1.9	4.2	-0.3	1.2	2.0
Crohns Disease (2017)	1.7	3.7	5.8	2.0	1.2	2.4
Sensitivity / hurt feelings	1.7	3.0	4.1	1.3	2.0	1.8
Eye problems/disorders: None of the above	1.7	2.0	2.4	1.5	1.2	1.6
Guilty feelings	1.7	2.5	3.4	1.3	1.8	1.5
Pain experienced in last month	1.7	2.8	4.6	0.1	2.1	2.0
Depression (Nagel 2018)	1.6	2.3	3.8	2.0	1.3	1.2
Worry (Nagel 2018)	1.6	3.4	5.2	1.1	1.9	2.3
Fed-up feelings	1.6	2.9	4.4	1.1	1.8	2.1
Health satisfaction	1.6	2.0	3.4	-1.0	-1.8	-1.3
Osteoarthritis (self-reported)	1.6	2.1	4.0	-0.6	-1.4	-2.0
Basal cell carcinoma (self-reported)	1.6	1.9	3.3	-1.1	-1.1	-1.8
Schizophrenia (2018)	1.5	3.1	4.6	2.1	1.6	1.5
Systolic blood pressure, automated reading	1.5	4.3	6.5	-0.9	2.3	2.5
Serious illness, injury or assault to yourself	1.5	1.8	2.2	-1.2	-1.3	-1.5
Father’s age at death	1.5	2.1	3.3	1.8	1.1	1.4
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.3	-0.1	-2.1	-1.7
Ovarian Cancer	1.4	1.8	2.5	-1.6	-1.3	-1.2
Allergy	1.4	3.2	3.5	1.8	1.6	1.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.1	-1.4	-1.3	-1.4
Emphysema/chronic bronchitis	1.4	1.5	2.3	-0.8	-1.5	-1.3
Medication: Aspirin	1.4	1.9	5.5	-2.4	0.1	0.1
Medication: Paracetamol	1.4	2.2	3.6	-1.9	-1.5	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	2.5	1.6	1.2	1.2
Suffer from ‘nerves’	1.3	2.1	3.9	0.9	1.2	2.0
Medication: Aspirin	1.3	1.7	5.1	-2.3	0.1	0.1
Long-standing illness, disability or infirmity	1.3	2.0	3.3	-1.8	-0.9	-1.4
Unable to work because of sickness or disability	1.3	1.7	2.3	-1.0	-1.5	-1.3
Supplements: Glucosamine	1.2	1.5	2.0	-1.4	-0.8	-1.4
Medication: Atenolol	1.2	1.5	3.5	0.4	1.9	1.0
Impedance of leg (left)	1.2	6.0	9.0	0.8	3.0	2.9
Illnesses of siblings	1.2	1.6	2.0	-1.2	-1.2	-1.4
Medication: Cholesterol lowering	1.2	1.9	2.7	-1.1	1.6	1.4
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.5	1.6	0.9	1.0
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	5.8	-2.4	-0.6	-0.9
Mineral and other dietary supplements	1.2	1.7	4.2	2.0	0.3	0.9
Wears glasses or contact lenses	1.2	1.4	2.2	0.2	1.4	1.5
Age at First Birth	1.1	1.6	1.7	1.2	1.2	1.3
Lung FVC	1.1	5.6	15.3	3.9	1.2	0.3
Impedance of leg (right)	1.1	5.2	7.8	0.9	2.8	2.6
Taking other prescription medications	1.1	1.7	2.8	-1.7	-1.0	-1.2
Age when periods started (menarche)	1.1	2.6	3.6	1.7	1.9	1.2
High blood pressure (siblings)	1.1	1.5	1.6	1.2	1.3	1.3
Leg fat-free mass (right)	1.1	6.0	7.6	-2.0	-2.8	-2.5
Illnesses of father: None of the above (group 1)	1.1	1.3	2.3	0.3	1.5	1.2
Leg predicted mass (right)	1.1	5.8	7.4	-1.9	-2.7	-2.5
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	-0.7	-1.0	-1.6
Heel T-Score	1.0	7.7	12.7	3.6	1.2	3.0
Relative age of first facial hair	1.0	2.1	2.8	1.7	1.0	1.5
Leg fat-free mass (left)	1.0	5.6	7.3	-1.9	-2.7	-2.4
Leg predicted mass (left)	1.0	5.2	6.8	-1.8	-2.6	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.2	1.2	1.5	1.8
Qualifications: A levels/AS levels or equivalent	1.0	2.1	3.6	-0.1	-1.7	-1.9
Illnesses of mother	1.0	1.2	2.0	0.9	-0.9	-1.4
Medication: Paracetamol	1.0	1.7	2.4	-1.2	-1.6	-1.2
Medication: Ventolin 100micrograms inhaler	1.0	1.2	1.9	0.8	1.4	1.1
Medication: Blood pressure	1.0	1.7	2.7	0.4	1.6	1.5
Friendships satisfaction	1.0	1.2	1.9	0.5	1.4	1.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.1	2.0	0.7	0.4
Mother’s age at death	1.0	1.2	1.9	0.7	1.1	1.4
Crohns Disease (2012)	0.9	1.4	2.6	1.2	0.6	1.6
Systolic Blood Pressure	0.9	4.3	6.6	-0.0	2.5	2.6
Medication: Simvastatin	0.9	1.3	4.0	-2.0	0.2	-0.0
Hair/balding pattern: Pattern 3	0.9	1.4	1.9	-1.0	1.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.7	-0.7	1.0	1.3
Supplements: Vitamin C	0.9	1.1	2.1	0.6	1.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.0	1.7	-0.1	0.1
Illnesses of father: High blood pressure	0.9	1.1	1.6	-1.3	-0.9	-1.0
Alcohol drinker status: Never	0.9	1.1	1.4	-0.6	-1.2	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	2.0	2.6	1.6	1.1	1.4
Coronary Artery Disease (CAD)	0.8	0.9	1.9	-1.4	0.6	0.8
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.3	-1.5	-0.8	-1.3
Number of treatments/medications taken	0.8	1.4	4.2	-2.0	0.1	-0.2
Had menopause	0.8	1.0	1.7	0.0	1.1	1.3
Alcohol intake versus 10 years previously	0.8	1.2	1.9	-0.6	1.1	1.4
Mouth/teeth dental problems: Dentures	0.8	1.3	2.8	-0.4	-1.7	-1.0
Pulse wave reflection index	0.8	1.0	1.4	-1.0	-0.7	-1.2
Worry too long after embarrassment	0.8	1.4	2.1	1.4	1.5	0.4
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.4	1.1	1.2	1.9
Breast Cancer	0.7	1.6	2.7	-1.2	-1.6	-0.8
Primary Biliary Cirrhosis	0.7	1.0	2.1	0.4	-0.8	-1.4
BMI	0.7	4.2	8.3	-1.0	-2.9	-1.8
Medication: Metformin	0.7	1.0	1.4	-1.2	-1.0	-0.9
Qualifications: CSEs or equivalent	0.7	0.9	1.8	0.7	-0.7	-1.3
Past tobacco smoking	0.7	1.3	3.5	1.9	-0.2	-0.4
Whole body fat-free mass	0.7	3.8	5.2	-1.5	-2.0	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.0	-1.4	-0.3	-0.7
Number of self-reported non-cancer illnesses	0.7	1.2	3.1	-1.8	-0.4	-0.6
Medication: Atorvastatin	0.7	0.9	1.4	-0.6	1.2	1.0
Ever smoked	0.7	1.2	3.6	-1.9	-0.3	0.0
Basal metabolic rate	0.7	4.0	4.8	-1.5	-2.2	-2.2
Heart disease (siblings)	0.7	0.8	1.0	1.0	0.8	0.9
Mean Putamen Volume	0.6	0.6	1.2	1.1	0.3	0.8
Medication for hormone replacement therapy	0.6	0.7	1.3	-0.5	-0.7	-1.1
Severe depression (siblings)	0.6	0.7	1.1	0.1	-1.0	-1.0
Medication: Ramipril	0.6	0.8	1.0	1.0	1.0	0.7
Birth weight of first child	0.6	1.0	2.0	0.4	0.9	1.4
Number of full sisters	0.6	0.7	1.1	0.6	0.9	1.1
Smoking status: Previous	0.6	1.0	1.3	-0.7	1.1	1.0
Whole body water mass	0.6	3.7	5.1	-1.4	-2.0	-2.2
Number of operations (self-reported)	0.6	0.9	1.8	-1.4	0.4	0.8
Hearing difficulty/problems: Yes	0.5	0.8	1.9	-1.4	-0.6	-0.5
Medication: Co-codamol	0.5	0.5	1.5	1.2	0.2	-0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.7	0.7	0.8	0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	-0.3	-1.1	-0.8
Trunk fat-free mass	0.5	3.0	4.9	-1.2	-1.7	-2.2
Trunk predicted mass	0.5	2.7	4.5	-1.1	-1.5	-2.1
Peak expiratory flow (PEF)	0.5	1.2	1.6	1.1	1.3	0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.0	1.0	0.9	0.3
Diabetes diagnosed by doctor	0.5	0.9	2.4	-1.5	-0.1	-0.5
Commuting to job workplace: Walk	0.5	0.5	0.7	0.8	0.7	0.6
Medication for cholesterol	0.5	0.7	0.9	1.0	0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.2	1.5	-0.2	-1.0
High cholesterol (Self-reported)	0.5	0.9	2.3	-1.5	0.6	0.3
Alcohol drinker status: Previous	0.5	0.6	0.9	0.9	0.8	0.5
Impedance of whole body	0.5	2.5	4.0	-0.3	1.9	2.0
Reaction Time	0.4	0.8	2.0	0.0	-0.7	-1.4
Prostate Cancer	0.4	0.5	1.4	1.2	0.1	-0.3
Rheumatoid Arthritis	0.4	0.6	1.0	0.0	-0.9	-1.0
Smoking Status	0.4	1.0	2.4	-1.5	-0.8	-0.2
Allergy or Eczema	0.4	1.1	1.9	-1.4	-0.5	-1.0
Lung FEV1/FVC ratio	0.4	2.0	2.7	-1.6	-0.7	-1.7
Hand grip strength (left)	0.4	1.0	2.5	1.6	0.7	0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.1	0.3	1.0	0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.6	-0.6	0.7	0.6
Supplements: Zinc	0.4	0.4	0.8	0.2	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.3	0.8	1.1	0.9
Sitting height	0.4	3.0	8.6	-2.9	0.0	-0.6
Waist circumference	0.4	1.4	2.5	-1.2	-1.6	-0.5
Financial difficulties in last 2 years	0.4	0.6	0.9	0.1	-0.9	-0.9
Mouth/teeth dental problems	0.4	0.6	1.6	-0.0	1.3	0.6
Diabetes (self-reported)	0.4	0.6	1.8	-1.3	-0.0	-0.3
Weight	0.4	2.1	3.6	-1.2	-1.9	-1.2
Time employed in main current job	0.4	0.4	0.5	0.4	0.7	0.7
Length of working week for main job	0.4	0.4	0.7	-0.5	-0.6	-0.8
Arm fat-free mass (right)	0.4	2.0	2.3	-1.5	-1.1	-1.5
Number of children fathered	0.4	0.4	0.7	0.4	0.8	0.6
Medication: Omeprazole	0.4	0.5	0.8	0.7	0.4	0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	0.5	0.4
Heart disease (mother)	0.4	0.5	1.1	0.5	1.0	0.4
Arm predicted mass (right)	0.4	2.0	2.6	-1.4	-1.2	-1.6
Chest pain or discomfort	0.4	0.6	1.7	-1.3	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	1.0	0.4	0.4
Illnesses of father: Heart disease	0.4	0.6	0.8	-0.8	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	0.9	-0.8	-1.0	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	-1.2	0.1	-0.0
Mood swings	0.4	0.7	1.1	0.6	1.0	0.9
Eye problems/disorders: Cataract	0.4	0.5	1.2	-1.1	0.5	0.0
Financial situation satisfaction	0.4	0.5	1.3	1.1	0.4	-0.2
Commuting to job workplace: Public transport	0.4	0.5	0.9	0.9	0.3	0.8
Lupus	0.3	0.5	1.2	1.1	0.5	-0.1
Height	0.3	6.0	17.5	-4.2	-0.1	-0.6
Average weekly spirits intake	0.3	0.4	1.1	-1.1	0.1	-0.3
Maternal smoking around birth	0.3	0.5	1.2	-1.1	-0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.2	0.9	0.4
Body mass index (BMI)	0.3	1.4	3.6	0.1	-1.9	-0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.3	0.6	1.0
Qualifications: None of the above	0.3	0.7	1.1	-0.7	0.7	1.1
Impedance of arm (right)	0.3	1.3	2.5	0.2	1.1	1.6
Hip circumference	0.3	1.4	3.0	-0.8	-1.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	-0.4	-0.7	-0.7
Impedance of arm (left)	0.3	1.2	2.2	-0.7	1.0	1.5
Forced vital capacity (FVC), Best measure	0.3	1.2	3.4	1.8	0.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	-1.1	0.2	0.1
Medication: Allopurinol	0.3	0.4	1.1	1.1	0.0	0.0
Whole body fat mass	0.3	1.2	2.6	-0.7	-1.6	-0.7
Alcohol intake frequency.	0.3	0.7	1.6	-0.5	-1.3	-0.6
Age at last live birth	0.3	0.4	0.7	0.5	-0.5	-0.8
Leg pain on walking	0.3	0.4	0.8	-0.9	0.0	0.6
Arm fat percentage (left)	0.3	1.1	3.0	-0.3	-1.7	-0.5
Medication: Gliclazide	0.3	0.4	1.1	-1.1	0.1	0.2
Arm fat mass (left)	0.3	1.1	2.8	-0.4	-1.7	-0.7
Risk taking	0.3	0.4	1.0	-1.0	0.3	-0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.6	-0.5	-0.1
Waist Hip Ratio (WHR)	0.2	0.8	1.3	-0.6	0.9	1.1
Cardiovascular Disease	0.2	0.7	1.4	0.2	1.2	0.8
Chronotype (morning person)	0.2	0.3	0.8	-0.4	0.9	0.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.4	-0.6	0.6	0.4
Angina	0.2	0.3	0.7	-0.8	0.5	0.0
Vitamin and mineral supplements	0.2	0.3	0.8	0.9	-0.2	0.1
Average weekly fortified wine intake	0.2	0.3	0.3	0.6	0.3	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	0.2	-0.5
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.6	-0.0	-0.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	0.9	-0.0	-0.0
Arm fat percentage (right)	0.2	0.7	2.1	0.2	-1.4	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.9	0.4	-0.5	-1.4
Medication: Lansoprazole	0.2	0.3	0.6	-0.8	-0.1	-0.5
Prospective memory result	0.2	0.2	0.3	-0.5	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.4	1.2	-0.2	-0.8
Arm fat mass (right)	0.2	1.0	2.7	-0.2	-1.6	-0.6
Standing height	0.2	2.4	6.6	-2.6	0.1	-0.8
Medication: Amlodipine	0.2	0.3	0.7	0.8	0.3	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	-0.0	-0.7	-0.6
Number of full brothers	0.2	0.2	0.4	-0.1	-0.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.6	0.4	-0.3
Qualifications: College or University degree	0.2	0.5	0.8	0.7	-0.5	-0.9
Angina (self-reported)	0.2	0.3	0.8	-0.9	0.4	0.0
Medication: Ibuprofen	0.2	0.3	0.3	-0.4	-0.5	-0.6
Leg fat mass (right)	0.2	0.7	1.8	0.0	-1.3	-0.4
Hypertension (Self-reported)	0.2	0.6	0.8	0.6	0.8	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.3	-0.5	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.4	-0.3	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.7	-0.5	-0.1
Arm fat-free mass (left)	0.2	0.9	1.3	-0.7	-0.9	-1.1
Diastolic blood pressure, automated reading	0.2	0.8	2.2	0.2	-0.1	1.5
Arm predicted mass (left)	0.2	1.1	1.7	-0.7	-1.0	-1.3
Alzheimer’s Disease (in mother)	0.1	0.2	0.2	-0.3	0.4	0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.3	-0.5	-0.2
Hair Pigment	0.1	3.4	4.3	2.1	1.9	1.6
Tanning	0.1	0.6	1.6	-0.2	-0.5	-1.3
Diabetes (mother)	0.1	0.2	0.5	-0.7	-0.2	-0.0
Pack years adult smoking proportion	0.1	0.2	0.5	-0.1	-0.7	-0.2
Trunk fat percentage	0.1	0.3	0.4	-0.6	-0.6	0.6
Hand grip strength (right)	0.1	0.3	0.7	0.8	0.4	0.3
High blood pressure	0.1	0.4	0.6	0.5	0.6	0.8
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.7	-0.3	-0.6
Multivitamins +/- minerals	0.1	0.2	0.4	-0.7	-0.3	-0.2
High blood pressure (mother)	0.1	0.2	0.3	-0.6	-0.4	0.0
Trunk fat mass	0.1	0.6	1.4	-0.7	-1.2	-0.2
Forced vital capacity (FVC)	0.1	0.4	0.9	0.9	0.1	-0.7
Pain all over the body in last month	0.1	0.1	0.2	-0.2	0.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.3	-0.6	-0.0
Noisy workplace	0.1	0.1	0.2	0.5	0.2	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.5	0.0	0.4
Loud music exposure frequency	0.1	0.1	0.2	-0.2	0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.7	-0.2	-0.5
Birth weight	0.1	0.2	0.4	0.4	0.2	0.6
Body fat percentage	0.1	0.4	1.0	-0.2	-1.0	0.2
Leg fat percentage (right)	0.1	0.3	0.4	0.6	-0.5	0.6
Pulse wave peak to peak time	0.1	0.1	0.3	0.5	0.2	-0.3
Migraine (self-reported)	0.1	0.1	0.3	0.0	-0.5	-0.1
Mean time to correctly identify matches	0.1	0.2	0.3	0.2	0.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.2	0.0	-0.5
Average weekly red wine intake	0.1	0.1	0.2	0.5	-0.2	-0.2
Loneliness, isolation	0.1	0.1	0.3	-0.1	0.3	0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.1	-0.2	-0.5
Breast cancer (self-reported)	0.1	0.2	0.3	-0.5	0.1	0.5
Medication: Blood pressure	0.1	0.2	0.5	0.7	0.3	0.4
Leg fat percentage (left)	0.1	0.3	0.6	0.5	-0.3	0.8
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.2	-0.4	-0.6
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.2	-0.1	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.2	-0.3	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.2	-0.0	0.5
Pack years of smoking	0.1	0.1	0.1	0.3	-0.1	0.4
Leg fat mass (left)	0.1	0.6	1.6	-0.1	-1.3	-0.3
Diabetes (father)	0.0	0.1	0.2	-0.0	-0.1	-0.4
Had other major operations	0.0	0.0	0.1	-0.1	-0.2	0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.1	0.2	-0.3	0.1
Gout (self-reported)	0.0	0.0	0.1	0.1	-0.0	0.2
Age at first live birth	0.0	0.1	0.1	0.2	-0.4	-0.2
Neck or shoulder pain in last month	0.0	0.1	0.1	0.2	0.4	0.2
Comparative height size at age 10	0.0	0.3	0.6	-0.8	0.1	-0.4
Back pain experienced in last month	0.0	0.1	0.1	-0.3	-0.2	-0.3
Osteoporosis (self-reported)	0.0	0.0	0.1	-0.0	0.1	-0.3
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.2	-0.3	0.0

Hub : Genes

MYRF

Models

Trait associations