Best TWAS P=1.43e-09 · Best GWAS P=3.12e-17 conditioned to 2.53e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Thyroid | ST3GAL4 | 0.18 | 0.05 | lasso | 9 | 0.04 | 0.00057 | 5.6 | -6.1 | 1.4e-09 | -0.06 | 0.52 | 0.07 | TRUE |
| 4 | GTEx | Spleen | RP11-680F20.12 | 0.38 | 0.00 | lasso | 6 | 0.00 | 0.23900 | -8.4 | -5.9 | 2.9e-09 | 0.65 | 0.02 | 0.77 | TRUE |
| 2 | GTEx | Nerve Tibial | CDON | 0.11 | 0.04 | lasso | 3 | 0.04 | 0.00138 | -4.7 | -5.4 | 8.3e-08 | 0.08 | 0.53 | 0.05 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | FEZ1 | 0.07 | 0.03 | lasso | 5 | 0.04 | 0.00031 | -4.2 | -5.9 | 4.4e-09 | 0.01 | 0.20 | 0.42 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | EI24 | 0.09 | 0.01 | lasso | 6 | 0.00 | 0.45900 | 5.5 | -5.8 | 8.6e-09 | -0.08 | 0.22 | 0.41 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | HYLS1 | 0.04 | 0.00 | blup | 56 | 0.01 | 0.02630 | 2.1 | -5.3 | 1.4e-07 | 0.03 | 0.02 | 0.68 | FALSE |