Hub : Genes

HYLS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.2280 0.065 8.7e-05 0.080 NA 0.060 NA 0.070 2.0e-04 NA 1.2e-03 NA 5.1e-04
2 METSIM Adipose 0.0794 0.027 4.5e-06 0.011 0.037 0.029 0.041 0.034 6.8e-03 2.5e-06 3.1e-05 7.9e-07 6.2e-06
3 YFS Blood 0.1492 0.030 0.0e+00 0.085 0.082 0.092 0.121 0.089 2.6e-26 1.3e-25 1.3e-28 1.6e-37 9.8e-28
4 TCGA Stomach Adenocarcinoma 0.0590 0.036 4.2e-03 0.053 0.032 0.023 NA 0.043 9.8e-05 2.1e-03 7.6e-03 NA 4.4e-04
5 TCGA Thyroid Carcinoma 0.0380 0.020 1.6e-03 0.000 0.011 0.002 NA -0.003 3.0e-01 2.6e-02 1.9e-01 NA 7.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.4 1.3 0.1 -0.0 -0.3 -0.9 1.2
Bipolar Disorder or Schizophrenia 0.1 0.3 1.0 -0.3 0.5 0.1 -1.0 -0.3
Depressed Affect (Nagel 2018) 0.5 1.0 3.7 0.2 1.9 -0.2 -0.6 0.8
Depression (Nagel 2018) 0.4 0.6 1.7 -0.4 1.3 -1.0 -0.2 0.4
Intelligence (Savage-Jansen 2018) 0.1 0.3 1.0 0.0 0.0 -0.8 1.0 -0.2
Neuroticism (Nagel 2018) 0.4 0.8 1.5 -0.3 1.2 0.2 -1.2 1.1
Schizophrenia (2018) 0.3 0.6 1.6 -0.4 0.7 0.4 -0.6 -1.3
Schizophrenia vs Biploar Disorder 1.8 2.4 5.1 -1.5 0.8 1.8 -2.3 1.0
Worry (Nagel 2018) 0.2 0.5 1.5 -0.3 0.6 -0.5 -0.6 1.2
Alzheimer’s Disease (in mother) 0.8 1.0 2.9 0.4 -0.4 -1.7 0.9 -0.9
Alzheimer’s Disease (in father) 0.8 0.9 1.2 -0.4 1.0 1.1 -0.9 1.1
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 0.1 0.4 -0.8 0.7 -0.7
Crohns Disease (2017) 0.5 1.1 2.2 1.0 -0.8 1.5 1.0 -0.8
Irritable Bowel Disease (IBD) 0.2 0.5 1.2 1.0 -0.7 -0.1 1.1 0.1
Ulcerative Colitis (UC) 0.4 0.7 1.9 0.0 -0.1 -1.4 0.7 1.0
Major Depression (MDD) 2.2 2.7 6.1 2.5 -0.4 0.2 2.4 -1.2
Reaction Time 0.3 0.6 2.1 -0.6 -0.1 -0.1 0.5 -1.5
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 -0.6 -0.1 -0.7 -0.0 0.0
Breast Cancer 0.8 1.9 4.5 -0.5 -2.1 -0.4 0.9 -1.9
Ovarian Cancer 0.7 1.0 3.3 -1.8 0.8 -0.6 -0.7 -0.3
Prostate Cancer 0.6 0.9 1.9 -0.1 -1.1 -1.0 0.5 1.4
Age at First Birth 0.8 1.2 3.6 -0.8 1.9 0.0 -1.1 0.8
Bipolar Disorder (2011) 1.0 0.9 4.1 -0.5 0.6 2.0 -0.1 -0.2
Body Mass Index (BMI) (2010) 3.5 4.8 8.2 2.9 -1.4 0.2 2.9 -2.4
Coronary Artery Disease (CAD) 1.0 1.1 1.7 -0.7 0.9 -1.3 -1.0 1.3
Crohns Disease (2012) 1.3 2.1 4.3 1.8 -1.0 -0.2 2.1 -1.3
Mean Putamen Volume 0.2 0.2 0.7 0.5 0.3 0.8 -0.0 0.0
Fasting Glucose 1.2 1.5 4.0 -0.6 -0.4 -2.0 -0.5 1.6
HbA1C 0.3 0.4 0.9 -0.1 0.7 -0.2 -0.6 0.9
HDL Cholesterol 1.0 1.7 3.9 -2.0 1.1 -0.4 -1.6 0.8
LDL Cholesterol 0.3 0.4 0.8 0.9 -0.6 0.5 0.6 -0.6
Lupus 0.0 0.0 0.1 -0.2 -0.0 0.3 0.3 -0.2
Neuroticism (2016) 0.7 1.0 1.9 0.9 0.6 -1.0 -1.1 1.4
Primary Biliary Cirrhosis 7.4 10.6 12.4 3.5 -3.1 -3.5 3.1 -3.0
Rheumatoid Arthritis 0.5 0.7 1.8 0.1 -0.6 0.7 -1.3 0.9
Schizophrenia (2014) 0.8 1.8 4.2 -1.4 1.3 1.0 -2.0 0.1
Triglycerides 1.2 2.0 3.3 1.8 -1.6 -1.4 1.5 0.1
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.9 1.7 -0.6 -1.7 0.9 -0.1
Ulcerative Colitis 2.0 2.9 5.3 1.2 -1.4 -2.3 2.0 -1.3
Blood Eosinophil Count 0.1 0.6 1.5 -1.2 -1.0 -0.7 -0.4 0.1
Blood Platelet Count 1.1 12.3 30.9 2.4 -3.0 -1.8 5.6 -3.6
Blood Red Count 0.1 0.7 2.1 -1.5 -0.5 0.3 -0.7 0.9
Blood White Count 0.2 1.2 2.7 -0.8 -0.7 -1.6 1.5 0.1
Heel T-Score 0.8 6.4 12.0 2.6 -1.4 3.2 1.1 -3.5
BMI 0.5 2.8 5.5 2.3 -0.0 0.6 1.6 -2.3
Height 0.8 15.4 47.7 -1.3 3.6 -0.0 -3.9 6.9
Waist Hip Ratio (WHR) 0.1 0.3 0.7 -0.3 -0.4 -0.8 0.6 -0.5
Systolic Blood Pressure 0.3 1.3 5.6 -0.1 0.3 -0.4 -0.9 2.4
Smoking Status 0.2 0.4 1.4 -0.0 -0.5 1.2 0.3 -0.5
Allergy or Eczema 0.2 0.5 1.5 -0.1 0.4 -0.5 -1.2 0.7
Cardiovascular Disease 0.3 1.0 2.7 0.6 0.6 -0.9 -0.8 1.6
Hypothyroidism (self reported) 0.3 0.6 1.6 -0.2 0.4 0.9 0.6 -1.3
Respiratory disease 0.1 0.3 0.7 0.8 -0.0 0.6 0.6 0.3
Type 2 Diabetes (T2D) (2018) 3.5 6.6 10.2 3.2 -2.1 0.8 3.2 -2.8
Lung FEV1/FVC ratio 1.5 7.6 27.7 2.3 -1.1 -0.8 1.7 -5.3
Lung FVC 0.8 4.2 7.8 -1.6 2.1 -2.8 -1.1 2.2
Neuroticism 0.4 1.0 2.2 0.0 1.5 0.3 -0.9 1.3
Chronotype (morning person) 0.3 0.8 3.3 0.1 0.4 -0.6 -0.3 1.8
Hair Pigment 0.0 0.6 1.4 -1.0 0.4 -0.2 -0.5 1.2
Tanning 0.0 0.5 1.2 0.3 -0.0 0.7 1.1 -0.9
Hand grip strength (left) 2.5 6.5 13.7 -2.0 1.9 -0.1 -3.7 3.3
Number of treatments/medications taken 0.6 1.0 2.4 -0.4 1.2 0.7 1.5 -0.7
Average weekly spirits intake 2.9 3.6 8.3 1.8 -0.2 -1.3 2.2 -2.9
Sensitivity / hurt feelings 0.8 1.3 2.8 -1.0 0.0 1.3 -1.7 1.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 0.9 -0.1 -0.6 0.3 -0.5
Hearing difficulty/problems: Yes 0.7 1.0 3.5 0.6 -0.3 0.9 0.5 -1.9
Relative age of first facial hair 0.5 1.1 2.7 -1.1 1.6 0.4 -0.0 1.2
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 4.7 0.5 0.2 0.7 1.6 -2.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 0.7 -0.2 0.3 1.1 -0.1
Ever had hysterectomy (womb removed) 0.2 0.2 0.7 0.8 0.3 -0.2 0.4 -0.4
Systolic blood pressure, automated reading 0.7 2.0 7.7 -0.4 1.0 0.4 -1.0 2.8
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.4 1.1 -1.2 1.0 1.1 -1.6
Angina 2.6 3.4 6.9 2.0 -0.6 -1.3 2.6 -1.9
Medication for hormone replacement therapy 0.3 0.3 0.8 0.2 0.2 -0.1 0.9 -0.9
Vitamin and mineral supplements 1.4 1.9 3.8 -1.0 1.1 -0.4 -1.8 1.9
Supplements: Zinc 1.3 1.4 2.7 1.7 -0.0 1.6 1.3 -0.2
Medication: Co-codamol 0.5 0.6 1.6 -1.3 1.0 -0.3 0.6 0.0
Medication: Metformin 4.1 5.7 11.1 2.4 -1.3 -0.1 3.2 -3.3
Diabetes (father) 0.3 0.4 0.6 0.4 -0.1 -0.8 0.7 -0.7
Diabetes (mother) 0.5 0.6 2.0 0.8 0.0 -0.5 1.4 -0.4
Severe depression (siblings) 0.4 0.4 1.3 1.1 -0.3 0.2 0.7 -0.5
Pack years adult smoking proportion 0.5 0.7 2.5 0.5 -1.6 0.1 -0.9 0.1
Impedance of leg (right) 0.3 1.3 3.8 -1.4 -0.1 -1.9 0.0 0.7
Leg fat-free mass (left) 0.2 1.0 1.2 1.0 0.9 1.1 -1.0 1.1
Trunk fat percentage 0.2 0.7 1.6 1.0 0.2 0.8 1.3 -0.7
Hand grip strength (right) 1.3 3.5 7.8 -1.5 1.1 -0.4 -2.5 2.8
Townsend deprivation index at recruitment 1.6 2.2 3.8 1.8 0.2 2.0 1.2 -1.5
Current tobacco smoking 0.6 0.9 3.2 -1.8 0.6 0.8 -0.5 -0.5
Average weekly fortified wine intake 1.5 1.7 4.6 1.5 0.1 0.1 1.3 -2.1
Maternal smoking around birth 0.3 0.4 1.2 0.8 0.1 1.1 -0.2 -0.2
Fed-up feelings 0.4 0.7 1.4 1.2 1.0 -0.2 0.7 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.9 -1.2 1.0 0.1 -1.4 0.5
Relative age voice broke 0.5 0.8 1.1 1.0 -1.0 0.1 1.0 -1.1
Taking other prescription medications 0.4 0.7 2.9 -0.1 0.5 -0.4 1.7 -0.3
Age when periods started (menarche) 1.3 3.1 6.7 -2.6 -1.1 -0.2 -1.9 1.9
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.0 1.1 0.5 0.2 1.1 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 4.3 2.1 0.0 -0.1 0.1 -0.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -0.9 0.9 0.6 -0.0 -0.1
Qualifications: CSEs or equivalent 0.5 0.7 2.2 -0.2 0.4 1.5 0.0 1.0
Serious illness, injury or assault to yourself 0.2 0.3 0.7 -0.7 0.5 0.8 -0.2 -0.2
High blood pressure 0.2 0.7 1.2 1.1 1.0 1.0 0.2 0.3
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.0 0.0 0.2 -1.4 -0.7 0.6
Multivitamins +/- minerals 0.6 0.8 1.4 0.2 -1.0 0.6 1.2 -1.2
Stomach or abdominal pain in last month 0.4 0.5 1.2 0.7 0.2 0.2 0.9 -1.1
Supplements: Glucosamine 0.6 0.8 3.0 0.3 0.7 -1.7 0.6 -0.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 0.6 0.0 1.1 1.0 -0.8
Medication: Atenolol 0.0 0.0 0.1 0.0 0.2 0.1 -0.3 -0.2
Medication: Levothyroxine sodium 0.3 0.4 0.9 0.3 0.2 0.5 0.9 -1.0
Sitting height 2.7 19.5 57.6 -2.4 2.9 -1.3 -4.9 7.6
Chronic bronchitis/emphysema (father) 0.2 0.2 0.4 0.5 -0.6 0.6 -0.4 0.3
High blood pressure (mother) 0.2 0.3 0.9 -0.0 0.0 -0.2 -0.7 1.0
Body mass index (BMI) 0.7 2.8 5.0 2.2 -0.2 2.0 1.5 -1.6
Impedance of leg (left) 0.3 1.4 3.1 -1.7 0.5 -1.7 -0.1 1.0
Leg predicted mass (left) 0.2 1.1 1.3 0.9 0.9 1.0 -1.1 1.1
Trunk fat mass 0.2 0.8 2.1 1.4 0.4 0.9 0.9 -0.5
Waist circumference 0.5 1.7 2.7 1.6 0.1 1.2 1.3 -1.6
Number of incorrect matches in round 0.4 0.7 1.9 -0.6 0.2 1.1 -1.4 0.4
Past tobacco smoking 0.4 0.7 1.2 -1.1 -0.3 -1.0 -0.9 -0.7
Alcohol usually taken with meals 0.6 1.0 3.0 -1.7 0.7 -0.6 -1.0 -0.1
Nervous feelings 1.6 3.0 4.9 -2.1 0.4 0.8 -2.2 2.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.4 -0.2 -0.1 -1.2 0.2 -0.4
Hearing difficulty/problems with background noise 1.7 2.7 5.9 -2.4 1.0 1.3 -2.3 0.1
Hair/balding pattern: Pattern 2 0.3 0.4 0.8 -0.7 0.2 0.7 -0.9 -0.1
Had menopause 0.3 0.4 0.6 0.8 -0.4 0.8 0.5 -0.5
Had other major operations 1.7 2.0 5.0 1.3 0.7 -1.6 2.2 -0.7
Forced vital capacity (FVC) 2.6 10.0 15.7 -2.5 3.7 -2.0 -3.2 4.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 4.4 2.1 -0.5 0.2 0.2 -0.4
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 3.8 1.1 0.2 2.0 1.0 -0.6
Qualifications: None of the above 0.7 1.6 3.6 -0.8 1.4 0.8 -0.9 1.9
Financial difficulties in last 2 years 0.6 0.8 1.2 -0.0 1.1 1.1 0.9 0.8
Mouth/teeth dental problems 0.6 0.9 2.2 -1.5 -1.4 -0.1 -0.4 -0.5
Heart attack 0.6 0.7 2.3 0.9 -0.0 0.8 1.5 -0.2
Allergy 0.1 0.3 0.5 -0.6 -0.1 0.7 -0.4 -0.7
Pain all over the body in last month 0.3 0.3 0.8 -0.2 0.2 0.5 0.8 -0.9
Diabetes (self-reported) 4.0 6.1 10.6 2.4 -2.0 0.3 3.2 -3.2
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.7 0.1 0.2 -0.9 -0.5 1.6
Medication: Ramipril 0.9 1.1 4.0 -0.5 -0.4 -2.0 -0.8 0.7
Medication: Simvastatin 0.2 0.4 0.7 -0.8 0.6 -0.4 -0.7 -0.3
Fluid intelligence score 0.3 0.5 1.8 -0.7 -0.1 -1.3 0.0 -0.6
Illnesses of siblings 1.0 1.4 4.7 -2.2 0.3 -0.4 -1.3 -0.5
Neuroticism score 0.4 0.9 1.8 0.1 0.8 0.7 -1.2 1.4
Weight 0.2 1.1 2.5 1.5 0.9 1.6 -0.2 0.4
Impedance of arm (right) 0.3 1.5 3.2 -1.8 0.0 -1.2 0.1 1.7
Arm fat percentage (right) 0.6 2.5 4.6 2.1 -0.3 1.1 2.1 -1.4
Trunk fat-free mass 0.4 2.3 3.8 0.6 1.7 0.9 -2.0 1.9
Hip circumference 0.3 1.4 3.1 1.7 0.8 1.8 0.6 -0.1
Time employed in main current job 1.4 1.6 4.8 0.8 -2.2 -0.8 1.0 -1.0
Alcohol intake versus 10 years previously 0.4 0.6 1.3 -0.8 1.1 -0.9 0.3 0.3
Father’s age at death 0.4 0.5 0.9 -0.7 -0.4 -0.9 -0.6 -1.0
Worrier / anxious feelings 2.1 3.9 7.8 -1.7 1.5 -0.2 -2.6 2.8
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.0 -1.4 -0.3 -0.4 -0.7 -0.7
Falls in the last year 0.7 0.9 1.4 -0.9 1.1 -1.2 1.0 -0.2
Hair/balding pattern: Pattern 3 0.8 1.1 3.9 2.0 -1.1 -0.2 0.7 0.3
Number of live births 0.4 0.6 1.1 -1.1 -0.0 -0.6 -0.6 1.0
Forced expiratory volume in 1-second (FEV1) 1.5 5.2 9.0 -1.7 3.0 -1.6 -2.5 2.4
Pulse rate 0.2 0.4 0.6 -0.4 -0.6 0.5 -0.6 0.8
Happiness 0.3 0.4 1.4 0.3 -1.2 -0.3 0.4 -0.6
Noisy workplace 0.5 0.6 1.9 0.5 -0.6 0.4 0.6 -1.4
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.5 -0.6 -1.2 0.1 0.6 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.3 0.7 -0.0 0.4 -0.5
Mouth/teeth dental problems: Dentures 0.9 1.5 4.0 0.1 1.5 -0.4 -1.0 2.0
Asthma 0.3 0.5 1.6 0.8 -0.5 -0.2 1.2 0.1
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 4.0 0.3 -0.1 0.4 1.6 -2.0
Medication: Cholesterol lowering 1.1 1.7 2.8 1.6 -1.0 0.6 1.4 -1.7
Depression (self-reported) 0.5 0.6 1.5 1.2 0.2 0.4 1.1 -0.0
Medication: Lansoprazole 1.4 1.6 5.3 -1.0 2.3 0.6 -0.4 1.0
Prospective memory result 3.3 4.0 8.0 -1.7 1.7 2.1 -2.8 1.4
Lung cancer (father) 0.6 0.7 1.6 -0.2 0.6 -1.3 -0.6 1.0
Illnesses of mother 0.2 0.3 0.8 -0.0 -0.1 0.9 0.1 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 9.2 -1.3 3.0 -1.3 -2.2 1.8
Pulse wave Arterial Stiffness index 2.4 2.8 4.8 -2.2 1.0 -1.2 -2.0 1.7
Impedance of arm (left) 0.4 1.7 3.5 -1.5 -1.0 -1.9 0.5 1.1
Arm fat mass (right) 0.4 1.6 4.5 2.1 0.1 1.2 1.3 -0.6
Trunk predicted mass 0.4 2.4 4.2 0.5 1.7 0.8 -2.0 2.0
Standing height 1.0 10.2 25.0 -1.8 2.6 -0.7 -3.9 5.0
Length of working week for main job 0.1 0.1 0.3 -0.6 0.4 -0.0 -0.1 -0.4
Exposure to tobacco smoke at home 1.1 1.2 2.8 -0.8 1.0 0.2 -1.2 1.7
Breastfed as a baby 1.0 1.3 3.1 0.3 -1.1 -0.3 1.4 -1.8
Tense / ‘highly strung’ 0.4 0.6 2.7 0.3 0.2 0.2 -0.5 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 0.5 -0.6 0.6 0.7 -1.0
Hair/balding pattern: Pattern 4 0.3 0.7 1.7 0.1 -0.0 -1.3 0.5 -1.1
Birth weight of first child 0.1 0.2 0.3 0.4 0.5 0.0 -0.5 -0.6
Peak expiratory flow (PEF) 0.6 1.4 4.0 -0.0 1.1 -0.8 -2.0 0.9
Pulse wave reflection index 2.3 2.8 6.2 -2.5 1.6 -0.0 -2.1 1.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.2 1.5 -0.0 1.3 1.1 -0.6
Loud music exposure frequency 1.8 2.0 4.4 -1.2 0.8 -0.5 -1.8 2.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.3 1.3 -1.8 -1.1 1.2 -1.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.2 -0.1 -0.1 0.4 -0.5
Blood clot in the leg (DVT) 1.4 1.8 2.9 1.6 -1.1 1.7 1.4 -0.7
Medication: Paracetamol 0.6 1.0 2.6 0.1 1.2 1.6 0.7 -0.8
Headache pain in last month 0.1 0.3 0.4 -0.4 0.5 -0.4 0.5 -0.6
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 5.5 -1.9 1.0 -0.0 -2.2 2.3
Glaucoma (self-reported) 1.4 1.7 4.5 0.5 -1.0 -2.1 1.0 -1.2
Gout (self-reported) 0.3 0.4 1.4 1.2 -0.3 0.4 0.3 -0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.6 -0.0 0.1 0.6 0.9 -1.3
Medication: Amlodipine 1.3 1.9 3.2 -1.0 1.7 1.8 -1.3 0.7
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.9 -1.3 1.7 1.3 -0.9 0.2
Birth weight 0.0 0.1 0.1 0.3 0.2 -0.4 0.4 -0.1
Chronic bronchitis/emphysema (mother) 1.4 1.7 4.4 0.3 0.0 0.5 -1.9 2.1
High blood pressure (siblings) 0.6 0.9 2.8 1.0 0.2 0.7 1.7 -0.0
Forced vital capacity (FVC), Best measure 2.1 7.7 14.7 -2.0 3.8 -1.6 -2.7 3.1
Body fat percentage 0.4 1.5 2.9 1.4 -0.0 0.8 1.7 -1.4
Leg fat percentage (right) 0.8 2.8 4.7 2.1 -0.3 0.8 2.1 -2.2
Arm fat-free mass (right) 0.3 1.4 2.3 0.7 1.4 0.9 -1.5 1.2
Exposure to tobacco smoke outside home 0.9 1.2 3.0 0.1 0.2 1.4 1.0 -1.7
Comparative body size at age 10 0.7 2.0 7.0 1.2 -0.4 -0.6 1.1 -2.6
Number of full brothers 0.8 1.0 2.5 -0.8 0.7 0.6 -1.6 0.9
Worry too long after embarrassment 0.2 0.3 1.0 -0.4 -0.2 0.6 -1.0 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.4 -0.9 1.6 -0.9 -0.6 1.4
Wheeze or whistling in the chest in last year 0.5 0.9 3.2 -1.8 0.3 -0.2 -1.0 0.6
Number of children fathered 1.2 1.4 2.0 -1.4 1.4 1.3 -0.4 1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.5 -0.9 0.4 0.4 -1.9 1.5
Age at first live birth 0.7 1.2 2.8 -1.7 0.4 -1.5 -0.3 -1.0
Pulse wave peak to peak time 2.0 2.3 4.9 2.2 -0.8 1.2 1.7 -1.3
Health satisfaction 0.6 0.8 1.5 1.0 -0.0 0.1 1.2 -1.2
Shortness of breath walking on level ground 0.7 0.9 1.7 0.4 1.1 1.1 0.4 -1.3
Qualifications: College or University degree 1.0 3.1 10.9 0.9 -0.6 0.3 1.8 -3.3
Eye problems/disorders: None of the above 0.6 0.7 1.9 -0.3 1.4 0.5 -0.8 0.8
Mouth/teeth dental problems: Loose teeth 1.5 1.8 4.4 1.6 -1.0 -0.0 1.0 -2.1
Emphysema/chronic bronchitis 1.2 1.3 2.4 1.3 -0.3 1.0 1.3 -1.6
Medication for pain relief, constipation, heartburn 1.3 2.2 4.0 -0.9 -0.1 -1.4 -2.0 2.0
Neck or shoulder pain in last month 0.5 0.7 2.5 0.2 1.6 0.9 0.5 -0.1
Medication: Blood pressure 0.6 1.1 2.5 1.1 -0.3 -0.4 1.4 -1.6
Angina (self-reported) 2.7 3.6 7.8 2.1 -0.7 -1.2 2.8 -2.0
Migraine (self-reported) 1.5 1.9 4.5 1.4 -0.9 0.5 2.1 -1.4
Medication: Ibuprofen 0.8 0.9 2.7 -0.2 -0.2 0.0 1.4 -1.6
Medication: Allopurinol 0.1 0.1 0.4 0.3 -0.2 0.6 -0.2 0.3
Medication: Omeprazole 0.5 0.5 1.9 0.4 -0.6 -0.1 1.4 -0.6
Medication: Seretide 50 evohaler 1.3 1.5 3.9 -2.0 0.8 -0.0 -1.1 1.4
Mean time to correctly identify matches 0.5 1.0 3.0 -1.7 0.5 -0.1 0.1 -1.2
Heart disease (mother) 0.2 0.2 0.7 0.1 -0.6 0.3 0.9 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.7 -1.5 1.7 -0.8 -0.2 0.3
Whole body fat mass 0.3 1.1 2.9 1.7 0.3 1.0 1.0 -0.6
Leg fat mass (right) 0.4 1.7 4.4 2.1 0.2 1.0 1.2 -1.4
Arm predicted mass (right) 0.2 1.1 1.6 1.0 1.3 0.9 -1.3 0.9
Pulse rate, automated reading 0.3 1.0 2.5 0.5 -1.6 -1.3 0.1 -0.6
Alcohol intake frequency. 0.5 1.1 2.8 0.2 0.0 -0.5 1.5 -1.7
Comparative height size at age 10 0.1 0.7 1.3 0.2 1.0 -0.3 -0.9 1.1
Number of full sisters 0.0 0.0 0.1 0.1 -0.0 -0.1 0.3 -0.1
Suffer from ‘nerves’ 0.1 0.1 0.5 0.4 -0.0 0.1 0.2 0.7
Overall health rating 0.6 1.3 4.1 0.7 1.0 -0.2 2.0 -0.9
Chest pain or discomfort 3.3 4.8 12.9 1.6 -1.1 -0.5 2.6 -3.6
Had major operations 1.0 1.1 1.7 0.6 -0.6 -1.2 1.3 -1.3
Age at last live birth 0.6 0.9 2.8 -1.7 -0.1 -0.7 0.2 -1.1
Family relationship satisfaction 0.3 0.4 0.8 0.2 -0.9 -0.8 -0.6 0.2
Leg pain on walking 2.2 2.7 6.4 1.4 0.2 -0.5 2.3 -2.5
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.4 -0.2 -0.0 0.3 -0.5
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.8 -0.2 -1.3 -0.2 -0.1 0.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.6 -0.8 -1.3 -0.9 0.1 0.8
Medication: Aspirin 0.8 1.0 2.4 0.7 -0.3 -1.0 1.5 -1.0
Supplements: Vitamin C 1.4 1.6 4.4 0.7 -0.5 0.2 1.7 -2.1
Knee pain experienced in last month 1.1 1.8 5.9 1.2 2.4 0.3 0.3 -1.1
Hypertension (Self-reported) 0.2 0.5 1.2 1.1 0.7 0.8 0.2 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.5 -1.2 0.1 0.1 -0.8 1.1
Illnesses of father: Heart disease 0.4 0.5 1.4 0.9 -0.3 -0.3 1.2 0.1
Illnesses of siblings: Diabetes 1.3 1.5 3.7 1.9 -1.0 0.4 1.3 -1.1
Smoking status: Previous 0.7 1.0 2.5 1.6 0.0 0.5 1.5 0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 5.8 -0.8 0.9 0.1 -2.4 2.4
Whole body fat-free mass 0.3 1.7 2.6 0.7 1.4 1.0 -1.6 1.6
Leg fat-free mass (right) 0.2 1.2 1.3 0.8 1.1 1.2 -1.2 1.2
Arm fat percentage (left) 0.9 3.6 6.3 2.4 -1.0 1.0 2.5 -2.0
Average weekly red wine intake 0.3 0.4 1.4 0.4 0.6 -0.4 -1.2 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 1.0 -0.9 0.6 0.6 0.3
Mood swings 0.2 0.4 0.8 0.5 0.8 0.2 -0.4 0.9
Loneliness, isolation 0.5 0.6 1.5 1.2 1.1 0.3 -0.6 -0.0
Long-standing illness, disability or infirmity 0.3 0.4 0.9 -0.1 0.5 0.6 0.9 -0.9
Ever had bowel cancer screening 0.6 0.7 1.9 0.1 1.0 -0.2 0.9 -1.4
Diabetes diagnosed by doctor 3.6 5.9 10.6 2.1 -2.0 0.2 3.2 -3.3
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.9 1.7 0.2 0.1 1.3 -1.5
Friendships satisfaction 1.1 1.4 2.3 -1.2 1.1 1.1 -1.5 0.9
Qualifications: nursing, teaching 0.9 1.4 5.3 0.6 -0.6 -0.9 0.6 -2.3
Commuting to job workplace: Walk 1.4 1.6 3.6 -0.6 1.9 -0.3 -1.9 0.6
Eye problems/disorders: Cataract 0.3 0.4 1.3 0.0 -0.6 0.5 0.0 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.2 0.7 1.1 0.4 0.7 -0.9
Medication for cholesterol 0.2 0.3 0.8 -0.5 -0.0 -0.5 -0.9 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.9 -0.7 0.6 -0.9 0.2 0.4
Back pain experienced in last month 0.5 0.8 3.6 0.3 1.9 0.3 0.0 -0.1
Mineral and other dietary supplements 1.0 1.3 2.4 -0.9 -1.5 -0.1 -1.1 1.5
Breast cancer (self-reported) 0.3 0.4 0.7 0.3 -0.4 0.7 0.8 -0.8
Asthma (self-reported) 0.3 0.5 1.5 0.9 -0.5 -0.1 1.2 0.1
Osteoporosis (self-reported) 3.1 3.8 7.6 2.3 -0.6 0.4 2.8 -2.4
Osteoarthritis (self-reported) 1.0 1.3 2.7 1.4 -0.3 -0.1 1.3 -1.6
Medication: Aspirin 0.5 0.7 1.3 0.5 -0.3 -0.8 1.2 -1.1
Medication: Gliclazide 3.4 3.8 4.8 2.2 -1.8 1.6 2.0 -2.1
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.3 -0.5 -0.3 -0.5 -0.6
Smoking status: Current 0.8 1.3 4.5 -2.1 0.5 0.9 -0.9 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.4 0.4 1.1 -0.6 -0.0 -1.2
Whole body water mass 0.3 1.9 3.0 0.6 1.5 0.9 -1.7 1.7
Leg predicted mass (right) 0.2 1.2 1.4 0.8 1.1 1.1 -1.2 1.2
Arm fat mass (left) 0.5 1.9 5.2 2.3 0.1 1.3 1.4 -0.8
Number of self-reported non-cancer illnesses 0.3 0.5 0.8 -0.3 0.9 0.8 0.9 -0.4
Average weekly champagne plus white wine intake 0.9 1.3 3.9 0.9 -0.4 2.0 0.4 -1.1
Miserableness 0.5 0.8 2.2 -0.1 1.1 0.4 -0.8 1.5
Guilty feelings 0.1 0.2 0.5 0.7 -0.4 0.3 0.3 -0.3
Wears glasses or contact lenses 0.2 0.2 0.5 -0.5 0.7 -0.2 0.0 -0.4
Ever taken oral contraceptive pill 0.7 0.8 2.7 0.3 -0.9 -1.6 0.7 -0.0
Hearing aid user 0.5 0.6 1.6 -0.4 0.3 0.6 -1.3 0.9
Mother’s age at death 0.9 1.2 4.7 0.5 0.6 2.2 -0.5 -0.5
Financial situation satisfaction 0.1 0.1 0.2 0.1 -0.2 0.2 0.4 -0.4
Tinnitus: Yes, now most or all of the time 1.3 1.5 5.0 -1.2 0.5 0.3 -2.2 1.0
Commuting to job workplace: Public transport 0.2 0.2 0.8 -0.0 0.1 0.9 0.6 -0.3
Eye problems/disorders: Glaucoma 1.0 1.2 2.8 0.0 -1.1 -1.7 0.9 -1.0
Medication: Blood pressure 0.5 0.9 1.7 0.8 0.4 1.2 -0.8 1.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.2 -0.3 1.5 -0.3 -0.3 -0.2
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.8 -0.2 1.9 -0.2 -0.5 -0.5
High cholesterol (Self-reported) 0.1 0.2 0.3 0.3 -0.5 0.2 0.5 -0.4
Medication: Bendroflumethiazide 1.1 1.6 4.5 -0.1 0.1 1.2 -1.5 2.1
Medication: Paracetamol 0.7 1.0 2.3 0.4 1.0 1.5 1.0 -0.7
Medication: Lisinopril 0.1 0.2 0.3 0.5 0.5 0.5 -0.1 0.2
Medication: Atorvastatin 2.3 2.8 4.7 2.2 -1.5 1.0 2.1 -1.3
Illnesses of father: High blood pressure 0.4 0.5 1.1 -1.1 0.5 -0.5 -0.4 0.7
Alcohol drinker status: Never 0.6 0.7 2.9 0.2 0.2 -1.7 0.4 -0.6
Ever smoked 0.6 1.0 2.1 0.5 1.0 1.4 0.1 1.5
Basal metabolic rate 0.3 1.5 2.0 1.0 1.4 1.1 -1.3 1.4
Leg fat percentage (left) 0.7 2.4 3.8 2.0 0.1 1.1 1.9 -1.9
Arm fat-free mass (left) 0.4 2.1 3.0 0.7 1.7 1.2 -1.6 1.7
Number of operations (self-reported) 1.5 2.2 5.1 1.2 0.4 -1.5 2.2 -1.5
Average weekly beer plus cider intake 0.2 0.2 0.8 -0.5 -0.1 0.2 -0.1 0.9
Irritability 0.2 0.3 0.9 -0.0 0.2 0.9 -0.6 0.2
Risk taking 0.4 0.5 1.2 -0.4 -0.1 1.1 0.7 -0.9
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.1 1.2 -0.1 -1.5 1.1 -1.2
Fractured/broken bones in last 5 years 2.9 3.8 7.4 -0.2 2.5 1.5 -1.6 2.7
Age started oral contraceptive pill 1.9 2.4 3.9 -1.8 1.4 0.2 -2.0 1.7
Diastolic blood pressure, automated reading 0.2 0.5 1.6 0.8 -0.4 -0.2 0.2 1.3
Ever depressed for a whole week 0.4 0.5 0.8 0.8 -0.2 0.7 0.4 -0.9
Unable to work because of sickness or disability 0.3 0.4 1.5 0.3 -0.2 0.1 1.2 -0.5
Commuting to job workplace: Cycle 0.3 0.4 1.6 0.5 0.4 0.0 0.0 -1.3
Myopia 1.0 1.5 3.2 0.8 -1.5 0.8 0.9 -1.8
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.6 -1.3 -1.1 -0.6 -0.6 -0.1
Cholesterol lowering medication 0.2 0.4 0.6 0.3 0.3 0.6 0.8 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.8 0.7 -0.8 -0.1 1.3 -1.2
Pain experienced in last month 0.6 1.1 3.7 -0.3 -1.9 -0.5 -0.5 1.0
Supplements: Calcium 0.1 0.2 0.4 -0.2 0.3 0.6 -0.2 -0.5
Basal cell carcinoma (self-reported) 0.4 0.4 1.4 1.2 -0.6 -0.1 0.6 -0.0
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.9 0.7 -0.0 0.8 1.4 0.2
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.5 1.4 -1.0 1.9 1.2 -0.9
Heart disease (siblings) 0.7 0.8 2.8 1.7 0.3 -0.5 1.0 0.1
Alcohol drinker status: Previous 0.9 1.1 2.1 0.7 1.4 1.4 0.5 -0.8
Pack years of smoking 0.5 0.8 2.5 0.6 -1.6 0.1 -1.0 0.1
Impedance of whole body 0.3 1.7 3.8 -1.9 -0.3 -1.9 0.3 1.1
Leg fat mass (left) 0.4 1.7 4.6 2.1 0.3 1.1 1.1 -1.2
Arm predicted mass (left) 0.5 2.5 3.8 0.6 1.9 1.4 -1.8 1.7