Hub : Genes

HYLS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.2280	0.065	8.7e-05	0.080	NA	0.060	NA	0.070	2.0e-04	NA	1.2e-03	NA	5.1e-04
2	METSIM	Adipose	0.0794	0.027	4.5e-06	0.011	0.037	0.029	0.041	0.034	6.8e-03	2.5e-06	3.1e-05	7.9e-07	6.2e-06
3	YFS	Blood	0.1492	0.030	0.0e+00	0.085	0.082	0.092	0.121	0.089	2.6e-26	1.3e-25	1.3e-28	1.6e-37	9.8e-28
4	TCGA	Stomach Adenocarcinoma	0.0590	0.036	4.2e-03	0.053	0.032	0.023	NA	0.043	9.8e-05	2.1e-03	7.6e-03	NA	4.4e-04
5	TCGA	Thyroid Carcinoma	0.0380	0.020	1.6e-03	0.000	0.011	0.002	NA	-0.003	3.0e-01	2.6e-02	1.9e-01	NA	7.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.4	1.3	0.1	-0.0	-0.3	-0.9	1.2
Bipolar Disorder or Schizophrenia	0.1	0.3	1.0	-0.3	0.5	0.1	-1.0	-0.3
Depressed Affect (Nagel 2018)	0.5	1.0	3.7	0.2	1.9	-0.2	-0.6	0.8
Depression (Nagel 2018)	0.4	0.6	1.7	-0.4	1.3	-1.0	-0.2	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.0	0.0	0.0	-0.8	1.0	-0.2
Neuroticism (Nagel 2018)	0.4	0.8	1.5	-0.3	1.2	0.2	-1.2	1.1
Schizophrenia (2018)	0.3	0.6	1.6	-0.4	0.7	0.4	-0.6	-1.3
Schizophrenia vs Biploar Disorder	1.8	2.4	5.1	-1.5	0.8	1.8	-2.3	1.0
Worry (Nagel 2018)	0.2	0.5	1.5	-0.3	0.6	-0.5	-0.6	1.2
Alzheimer’s Disease (in mother)	0.8	1.0	2.9	0.4	-0.4	-1.7	0.9	-0.9
Alzheimer’s Disease (in father)	0.8	0.9	1.2	-0.4	1.0	1.1	-0.9	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.1	0.4	-0.8	0.7	-0.7
Crohns Disease (2017)	0.5	1.1	2.2	1.0	-0.8	1.5	1.0	-0.8
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	1.0	-0.7	-0.1	1.1	0.1
Ulcerative Colitis (UC)	0.4	0.7	1.9	0.0	-0.1	-1.4	0.7	1.0
Major Depression (MDD)	2.2	2.7	6.1	2.5	-0.4	0.2	2.4	-1.2
Reaction Time	0.3	0.6	2.1	-0.6	-0.1	-0.1	0.5	-1.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.6	-0.1	-0.7	-0.0	0.0
Breast Cancer	0.8	1.9	4.5	-0.5	-2.1	-0.4	0.9	-1.9
Ovarian Cancer	0.7	1.0	3.3	-1.8	0.8	-0.6	-0.7	-0.3
Prostate Cancer	0.6	0.9	1.9	-0.1	-1.1	-1.0	0.5	1.4
Age at First Birth	0.8	1.2	3.6	-0.8	1.9	0.0	-1.1	0.8
Bipolar Disorder (2011)	1.0	0.9	4.1	-0.5	0.6	2.0	-0.1	-0.2
Body Mass Index (BMI) (2010)	3.5	4.8	8.2	2.9	-1.4	0.2	2.9	-2.4
Coronary Artery Disease (CAD)	1.0	1.1	1.7	-0.7	0.9	-1.3	-1.0	1.3
Crohns Disease (2012)	1.3	2.1	4.3	1.8	-1.0	-0.2	2.1	-1.3
Mean Putamen Volume	0.2	0.2	0.7	0.5	0.3	0.8	-0.0	0.0
Fasting Glucose	1.2	1.5	4.0	-0.6	-0.4	-2.0	-0.5	1.6
HbA1C	0.3	0.4	0.9	-0.1	0.7	-0.2	-0.6	0.9
HDL Cholesterol	1.0	1.7	3.9	-2.0	1.1	-0.4	-1.6	0.8
LDL Cholesterol	0.3	0.4	0.8	0.9	-0.6	0.5	0.6	-0.6
Lupus	0.0	0.0	0.1	-0.2	-0.0	0.3	0.3	-0.2
Neuroticism (2016)	0.7	1.0	1.9	0.9	0.6	-1.0	-1.1	1.4
Primary Biliary Cirrhosis	7.4	10.6	12.4	3.5	-3.1	-3.5	3.1	-3.0
Rheumatoid Arthritis	0.5	0.7	1.8	0.1	-0.6	0.7	-1.3	0.9
Schizophrenia (2014)	0.8	1.8	4.2	-1.4	1.3	1.0	-2.0	0.1
Triglycerides	1.2	2.0	3.3	1.8	-1.6	-1.4	1.5	0.1
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.9	1.7	-0.6	-1.7	0.9	-0.1
Ulcerative Colitis	2.0	2.9	5.3	1.2	-1.4	-2.3	2.0	-1.3
Blood Eosinophil Count	0.1	0.6	1.5	-1.2	-1.0	-0.7	-0.4	0.1
Blood Platelet Count	1.1	12.3	30.9	2.4	-3.0	-1.8	5.6	-3.6
Blood Red Count	0.1	0.7	2.1	-1.5	-0.5	0.3	-0.7	0.9
Blood White Count	0.2	1.2	2.7	-0.8	-0.7	-1.6	1.5	0.1
Heel T-Score	0.8	6.4	12.0	2.6	-1.4	3.2	1.1	-3.5
BMI	0.5	2.8	5.5	2.3	-0.0	0.6	1.6	-2.3
Height	0.8	15.4	47.7	-1.3	3.6	-0.0	-3.9	6.9
Waist Hip Ratio (WHR)	0.1	0.3	0.7	-0.3	-0.4	-0.8	0.6	-0.5
Systolic Blood Pressure	0.3	1.3	5.6	-0.1	0.3	-0.4	-0.9	2.4
Smoking Status	0.2	0.4	1.4	-0.0	-0.5	1.2	0.3	-0.5
Allergy or Eczema	0.2	0.5	1.5	-0.1	0.4	-0.5	-1.2	0.7
Cardiovascular Disease	0.3	1.0	2.7	0.6	0.6	-0.9	-0.8	1.6
Hypothyroidism (self reported)	0.3	0.6	1.6	-0.2	0.4	0.9	0.6	-1.3
Respiratory disease	0.1	0.3	0.7	0.8	-0.0	0.6	0.6	0.3
Type 2 Diabetes (T2D) (2018)	3.5	6.6	10.2	3.2	-2.1	0.8	3.2	-2.8
Lung FEV1/FVC ratio	1.5	7.6	27.7	2.3	-1.1	-0.8	1.7	-5.3
Lung FVC	0.8	4.2	7.8	-1.6	2.1	-2.8	-1.1	2.2
Neuroticism	0.4	1.0	2.2	0.0	1.5	0.3	-0.9	1.3
Chronotype (morning person)	0.3	0.8	3.3	0.1	0.4	-0.6	-0.3	1.8
Hair Pigment	0.0	0.6	1.4	-1.0	0.4	-0.2	-0.5	1.2
Tanning	0.0	0.5	1.2	0.3	-0.0	0.7	1.1	-0.9
Hand grip strength (left)	2.5	6.5	13.7	-2.0	1.9	-0.1	-3.7	3.3
Number of treatments/medications taken	0.6	1.0	2.4	-0.4	1.2	0.7	1.5	-0.7
Average weekly spirits intake	2.9	3.6	8.3	1.8	-0.2	-1.3	2.2	-2.9
Sensitivity / hurt feelings	0.8	1.3	2.8	-1.0	0.0	1.3	-1.7	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.9	-0.1	-0.6	0.3	-0.5
Hearing difficulty/problems: Yes	0.7	1.0	3.5	0.6	-0.3	0.9	0.5	-1.9
Relative age of first facial hair	0.5	1.1	2.7	-1.1	1.6	0.4	-0.0	1.2
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.7	0.5	0.2	0.7	1.6	-2.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	0.7	-0.2	0.3	1.1	-0.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.8	0.3	-0.2	0.4	-0.4
Systolic blood pressure, automated reading	0.7	2.0	7.7	-0.4	1.0	0.4	-1.0	2.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.4	1.1	-1.2	1.0	1.1	-1.6
Angina	2.6	3.4	6.9	2.0	-0.6	-1.3	2.6	-1.9
Medication for hormone replacement therapy	0.3	0.3	0.8	0.2	0.2	-0.1	0.9	-0.9
Vitamin and mineral supplements	1.4	1.9	3.8	-1.0	1.1	-0.4	-1.8	1.9
Supplements: Zinc	1.3	1.4	2.7	1.7	-0.0	1.6	1.3	-0.2
Medication: Co-codamol	0.5	0.6	1.6	-1.3	1.0	-0.3	0.6	0.0
Medication: Metformin	4.1	5.7	11.1	2.4	-1.3	-0.1	3.2	-3.3
Diabetes (father)	0.3	0.4	0.6	0.4	-0.1	-0.8	0.7	-0.7
Diabetes (mother)	0.5	0.6	2.0	0.8	0.0	-0.5	1.4	-0.4
Severe depression (siblings)	0.4	0.4	1.3	1.1	-0.3	0.2	0.7	-0.5
Pack years adult smoking proportion	0.5	0.7	2.5	0.5	-1.6	0.1	-0.9	0.1
Impedance of leg (right)	0.3	1.3	3.8	-1.4	-0.1	-1.9	0.0	0.7
Leg fat-free mass (left)	0.2	1.0	1.2	1.0	0.9	1.1	-1.0	1.1
Trunk fat percentage	0.2	0.7	1.6	1.0	0.2	0.8	1.3	-0.7
Hand grip strength (right)	1.3	3.5	7.8	-1.5	1.1	-0.4	-2.5	2.8
Townsend deprivation index at recruitment	1.6	2.2	3.8	1.8	0.2	2.0	1.2	-1.5
Current tobacco smoking	0.6	0.9	3.2	-1.8	0.6	0.8	-0.5	-0.5
Average weekly fortified wine intake	1.5	1.7	4.6	1.5	0.1	0.1	1.3	-2.1
Maternal smoking around birth	0.3	0.4	1.2	0.8	0.1	1.1	-0.2	-0.2
Fed-up feelings	0.4	0.7	1.4	1.2	1.0	-0.2	0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.9	-1.2	1.0	0.1	-1.4	0.5
Relative age voice broke	0.5	0.8	1.1	1.0	-1.0	0.1	1.0	-1.1
Taking other prescription medications	0.4	0.7	2.9	-0.1	0.5	-0.4	1.7	-0.3
Age when periods started (menarche)	1.3	3.1	6.7	-2.6	-1.1	-0.2	-1.9	1.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	1.1	0.5	0.2	1.1	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.3	2.1	0.0	-0.1	0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.9	0.9	0.6	-0.0	-0.1
Qualifications: CSEs or equivalent	0.5	0.7	2.2	-0.2	0.4	1.5	0.0	1.0
Serious illness, injury or assault to yourself	0.2	0.3	0.7	-0.7	0.5	0.8	-0.2	-0.2
High blood pressure	0.2	0.7	1.2	1.1	1.0	1.0	0.2	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.0	0.0	0.2	-1.4	-0.7	0.6
Multivitamins +/- minerals	0.6	0.8	1.4	0.2	-1.0	0.6	1.2	-1.2
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.7	0.2	0.2	0.9	-1.1
Supplements: Glucosamine	0.6	0.8	3.0	0.3	0.7	-1.7	0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	0.6	0.0	1.1	1.0	-0.8
Medication: Atenolol	0.0	0.0	0.1	0.0	0.2	0.1	-0.3	-0.2
Medication: Levothyroxine sodium	0.3	0.4	0.9	0.3	0.2	0.5	0.9	-1.0
Sitting height	2.7	19.5	57.6	-2.4	2.9	-1.3	-4.9	7.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.5	-0.6	0.6	-0.4	0.3
High blood pressure (mother)	0.2	0.3	0.9	-0.0	0.0	-0.2	-0.7	1.0
Body mass index (BMI)	0.7	2.8	5.0	2.2	-0.2	2.0	1.5	-1.6
Impedance of leg (left)	0.3	1.4	3.1	-1.7	0.5	-1.7	-0.1	1.0
Leg predicted mass (left)	0.2	1.1	1.3	0.9	0.9	1.0	-1.1	1.1
Trunk fat mass	0.2	0.8	2.1	1.4	0.4	0.9	0.9	-0.5
Waist circumference	0.5	1.7	2.7	1.6	0.1	1.2	1.3	-1.6
Number of incorrect matches in round	0.4	0.7	1.9	-0.6	0.2	1.1	-1.4	0.4
Past tobacco smoking	0.4	0.7	1.2	-1.1	-0.3	-1.0	-0.9	-0.7
Alcohol usually taken with meals	0.6	1.0	3.0	-1.7	0.7	-0.6	-1.0	-0.1
Nervous feelings	1.6	3.0	4.9	-2.1	0.4	0.8	-2.2	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	-0.2	-0.1	-1.2	0.2	-0.4
Hearing difficulty/problems with background noise	1.7	2.7	5.9	-2.4	1.0	1.3	-2.3	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	-0.7	0.2	0.7	-0.9	-0.1
Had menopause	0.3	0.4	0.6	0.8	-0.4	0.8	0.5	-0.5
Had other major operations	1.7	2.0	5.0	1.3	0.7	-1.6	2.2	-0.7
Forced vital capacity (FVC)	2.6	10.0	15.7	-2.5	3.7	-2.0	-3.2	4.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.4	2.1	-0.5	0.2	0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.8	1.1	0.2	2.0	1.0	-0.6
Qualifications: None of the above	0.7	1.6	3.6	-0.8	1.4	0.8	-0.9	1.9
Financial difficulties in last 2 years	0.6	0.8	1.2	-0.0	1.1	1.1	0.9	0.8
Mouth/teeth dental problems	0.6	0.9	2.2	-1.5	-1.4	-0.1	-0.4	-0.5
Heart attack	0.6	0.7	2.3	0.9	-0.0	0.8	1.5	-0.2
Allergy	0.1	0.3	0.5	-0.6	-0.1	0.7	-0.4	-0.7
Pain all over the body in last month	0.3	0.3	0.8	-0.2	0.2	0.5	0.8	-0.9
Diabetes (self-reported)	4.0	6.1	10.6	2.4	-2.0	0.3	3.2	-3.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.7	0.1	0.2	-0.9	-0.5	1.6
Medication: Ramipril	0.9	1.1	4.0	-0.5	-0.4	-2.0	-0.8	0.7
Medication: Simvastatin	0.2	0.4	0.7	-0.8	0.6	-0.4	-0.7	-0.3
Fluid intelligence score	0.3	0.5	1.8	-0.7	-0.1	-1.3	0.0	-0.6
Illnesses of siblings	1.0	1.4	4.7	-2.2	0.3	-0.4	-1.3	-0.5
Neuroticism score	0.4	0.9	1.8	0.1	0.8	0.7	-1.2	1.4
Weight	0.2	1.1	2.5	1.5	0.9	1.6	-0.2	0.4
Impedance of arm (right)	0.3	1.5	3.2	-1.8	0.0	-1.2	0.1	1.7
Arm fat percentage (right)	0.6	2.5	4.6	2.1	-0.3	1.1	2.1	-1.4
Trunk fat-free mass	0.4	2.3	3.8	0.6	1.7	0.9	-2.0	1.9
Hip circumference	0.3	1.4	3.1	1.7	0.8	1.8	0.6	-0.1
Time employed in main current job	1.4	1.6	4.8	0.8	-2.2	-0.8	1.0	-1.0
Alcohol intake versus 10 years previously	0.4	0.6	1.3	-0.8	1.1	-0.9	0.3	0.3
Father’s age at death	0.4	0.5	0.9	-0.7	-0.4	-0.9	-0.6	-1.0
Worrier / anxious feelings	2.1	3.9	7.8	-1.7	1.5	-0.2	-2.6	2.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.0	-1.4	-0.3	-0.4	-0.7	-0.7
Falls in the last year	0.7	0.9	1.4	-0.9	1.1	-1.2	1.0	-0.2
Hair/balding pattern: Pattern 3	0.8	1.1	3.9	2.0	-1.1	-0.2	0.7	0.3
Number of live births	0.4	0.6	1.1	-1.1	-0.0	-0.6	-0.6	1.0
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	9.0	-1.7	3.0	-1.6	-2.5	2.4
Pulse rate	0.2	0.4	0.6	-0.4	-0.6	0.5	-0.6	0.8
Happiness	0.3	0.4	1.4	0.3	-1.2	-0.3	0.4	-0.6
Noisy workplace	0.5	0.6	1.9	0.5	-0.6	0.4	0.6	-1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-0.6	-1.2	0.1	0.6	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.3	0.7	-0.0	0.4	-0.5
Mouth/teeth dental problems: Dentures	0.9	1.5	4.0	0.1	1.5	-0.4	-1.0	2.0
Asthma	0.3	0.5	1.6	0.8	-0.5	-0.2	1.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.0	0.3	-0.1	0.4	1.6	-2.0
Medication: Cholesterol lowering	1.1	1.7	2.8	1.6	-1.0	0.6	1.4	-1.7
Depression (self-reported)	0.5	0.6	1.5	1.2	0.2	0.4	1.1	-0.0
Medication: Lansoprazole	1.4	1.6	5.3	-1.0	2.3	0.6	-0.4	1.0
Prospective memory result	3.3	4.0	8.0	-1.7	1.7	2.1	-2.8	1.4
Lung cancer (father)	0.6	0.7	1.6	-0.2	0.6	-1.3	-0.6	1.0
Illnesses of mother	0.2	0.3	0.8	-0.0	-0.1	0.9	0.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	9.2	-1.3	3.0	-1.3	-2.2	1.8
Pulse wave Arterial Stiffness index	2.4	2.8	4.8	-2.2	1.0	-1.2	-2.0	1.7
Impedance of arm (left)	0.4	1.7	3.5	-1.5	-1.0	-1.9	0.5	1.1
Arm fat mass (right)	0.4	1.6	4.5	2.1	0.1	1.2	1.3	-0.6
Trunk predicted mass	0.4	2.4	4.2	0.5	1.7	0.8	-2.0	2.0
Standing height	1.0	10.2	25.0	-1.8	2.6	-0.7	-3.9	5.0
Length of working week for main job	0.1	0.1	0.3	-0.6	0.4	-0.0	-0.1	-0.4
Exposure to tobacco smoke at home	1.1	1.2	2.8	-0.8	1.0	0.2	-1.2	1.7
Breastfed as a baby	1.0	1.3	3.1	0.3	-1.1	-0.3	1.4	-1.8
Tense / ‘highly strung’	0.4	0.6	2.7	0.3	0.2	0.2	-0.5	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	0.5	-0.6	0.6	0.7	-1.0
Hair/balding pattern: Pattern 4	0.3	0.7	1.7	0.1	-0.0	-1.3	0.5	-1.1
Birth weight of first child	0.1	0.2	0.3	0.4	0.5	0.0	-0.5	-0.6
Peak expiratory flow (PEF)	0.6	1.4	4.0	-0.0	1.1	-0.8	-2.0	0.9
Pulse wave reflection index	2.3	2.8	6.2	-2.5	1.6	-0.0	-2.1	1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	1.5	-0.0	1.3	1.1	-0.6
Loud music exposure frequency	1.8	2.0	4.4	-1.2	0.8	-0.5	-1.8	2.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.3	1.3	-1.8	-1.1	1.2	-1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.2	-0.1	-0.1	0.4	-0.5
Blood clot in the leg (DVT)	1.4	1.8	2.9	1.6	-1.1	1.7	1.4	-0.7
Medication: Paracetamol	0.6	1.0	2.6	0.1	1.2	1.6	0.7	-0.8
Headache pain in last month	0.1	0.3	0.4	-0.4	0.5	-0.4	0.5	-0.6
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.5	-1.9	1.0	-0.0	-2.2	2.3
Glaucoma (self-reported)	1.4	1.7	4.5	0.5	-1.0	-2.1	1.0	-1.2
Gout (self-reported)	0.3	0.4	1.4	1.2	-0.3	0.4	0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	-0.0	0.1	0.6	0.9	-1.3
Medication: Amlodipine	1.3	1.9	3.2	-1.0	1.7	1.8	-1.3	0.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.9	-1.3	1.7	1.3	-0.9	0.2
Birth weight	0.0	0.1	0.1	0.3	0.2	-0.4	0.4	-0.1
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.4	0.3	0.0	0.5	-1.9	2.1
High blood pressure (siblings)	0.6	0.9	2.8	1.0	0.2	0.7	1.7	-0.0
Forced vital capacity (FVC), Best measure	2.1	7.7	14.7	-2.0	3.8	-1.6	-2.7	3.1
Body fat percentage	0.4	1.5	2.9	1.4	-0.0	0.8	1.7	-1.4
Leg fat percentage (right)	0.8	2.8	4.7	2.1	-0.3	0.8	2.1	-2.2
Arm fat-free mass (right)	0.3	1.4	2.3	0.7	1.4	0.9	-1.5	1.2
Exposure to tobacco smoke outside home	0.9	1.2	3.0	0.1	0.2	1.4	1.0	-1.7
Comparative body size at age 10	0.7	2.0	7.0	1.2	-0.4	-0.6	1.1	-2.6
Number of full brothers	0.8	1.0	2.5	-0.8	0.7	0.6	-1.6	0.9
Worry too long after embarrassment	0.2	0.3	1.0	-0.4	-0.2	0.6	-1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.4	-0.9	1.6	-0.9	-0.6	1.4
Wheeze or whistling in the chest in last year	0.5	0.9	3.2	-1.8	0.3	-0.2	-1.0	0.6
Number of children fathered	1.2	1.4	2.0	-1.4	1.4	1.3	-0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.5	-0.9	0.4	0.4	-1.9	1.5
Age at first live birth	0.7	1.2	2.8	-1.7	0.4	-1.5	-0.3	-1.0
Pulse wave peak to peak time	2.0	2.3	4.9	2.2	-0.8	1.2	1.7	-1.3
Health satisfaction	0.6	0.8	1.5	1.0	-0.0	0.1	1.2	-1.2
Shortness of breath walking on level ground	0.7	0.9	1.7	0.4	1.1	1.1	0.4	-1.3
Qualifications: College or University degree	1.0	3.1	10.9	0.9	-0.6	0.3	1.8	-3.3
Eye problems/disorders: None of the above	0.6	0.7	1.9	-0.3	1.4	0.5	-0.8	0.8
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.4	1.6	-1.0	-0.0	1.0	-2.1
Emphysema/chronic bronchitis	1.2	1.3	2.4	1.3	-0.3	1.0	1.3	-1.6
Medication for pain relief, constipation, heartburn	1.3	2.2	4.0	-0.9	-0.1	-1.4	-2.0	2.0
Neck or shoulder pain in last month	0.5	0.7	2.5	0.2	1.6	0.9	0.5	-0.1
Medication: Blood pressure	0.6	1.1	2.5	1.1	-0.3	-0.4	1.4	-1.6
Angina (self-reported)	2.7	3.6	7.8	2.1	-0.7	-1.2	2.8	-2.0
Migraine (self-reported)	1.5	1.9	4.5	1.4	-0.9	0.5	2.1	-1.4
Medication: Ibuprofen	0.8	0.9	2.7	-0.2	-0.2	0.0	1.4	-1.6
Medication: Allopurinol	0.1	0.1	0.4	0.3	-0.2	0.6	-0.2	0.3
Medication: Omeprazole	0.5	0.5	1.9	0.4	-0.6	-0.1	1.4	-0.6
Medication: Seretide 50 evohaler	1.3	1.5	3.9	-2.0	0.8	-0.0	-1.1	1.4
Mean time to correctly identify matches	0.5	1.0	3.0	-1.7	0.5	-0.1	0.1	-1.2
Heart disease (mother)	0.2	0.2	0.7	0.1	-0.6	0.3	0.9	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.7	-1.5	1.7	-0.8	-0.2	0.3
Whole body fat mass	0.3	1.1	2.9	1.7	0.3	1.0	1.0	-0.6
Leg fat mass (right)	0.4	1.7	4.4	2.1	0.2	1.0	1.2	-1.4
Arm predicted mass (right)	0.2	1.1	1.6	1.0	1.3	0.9	-1.3	0.9
Pulse rate, automated reading	0.3	1.0	2.5	0.5	-1.6	-1.3	0.1	-0.6
Alcohol intake frequency.	0.5	1.1	2.8	0.2	0.0	-0.5	1.5	-1.7
Comparative height size at age 10	0.1	0.7	1.3	0.2	1.0	-0.3	-0.9	1.1
Number of full sisters	0.0	0.0	0.1	0.1	-0.0	-0.1	0.3	-0.1
Suffer from ‘nerves’	0.1	0.1	0.5	0.4	-0.0	0.1	0.2	0.7
Overall health rating	0.6	1.3	4.1	0.7	1.0	-0.2	2.0	-0.9
Chest pain or discomfort	3.3	4.8	12.9	1.6	-1.1	-0.5	2.6	-3.6
Had major operations	1.0	1.1	1.7	0.6	-0.6	-1.2	1.3	-1.3
Age at last live birth	0.6	0.9	2.8	-1.7	-0.1	-0.7	0.2	-1.1
Family relationship satisfaction	0.3	0.4	0.8	0.2	-0.9	-0.8	-0.6	0.2
Leg pain on walking	2.2	2.7	6.4	1.4	0.2	-0.5	2.3	-2.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	-0.2	-0.0	0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.8	-0.2	-1.3	-0.2	-0.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.6	-0.8	-1.3	-0.9	0.1	0.8
Medication: Aspirin	0.8	1.0	2.4	0.7	-0.3	-1.0	1.5	-1.0
Supplements: Vitamin C	1.4	1.6	4.4	0.7	-0.5	0.2	1.7	-2.1
Knee pain experienced in last month	1.1	1.8	5.9	1.2	2.4	0.3	0.3	-1.1
Hypertension (Self-reported)	0.2	0.5	1.2	1.1	0.7	0.8	0.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-1.2	0.1	0.1	-0.8	1.1
Illnesses of father: Heart disease	0.4	0.5	1.4	0.9	-0.3	-0.3	1.2	0.1
Illnesses of siblings: Diabetes	1.3	1.5	3.7	1.9	-1.0	0.4	1.3	-1.1
Smoking status: Previous	0.7	1.0	2.5	1.6	0.0	0.5	1.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	5.8	-0.8	0.9	0.1	-2.4	2.4
Whole body fat-free mass	0.3	1.7	2.6	0.7	1.4	1.0	-1.6	1.6
Leg fat-free mass (right)	0.2	1.2	1.3	0.8	1.1	1.2	-1.2	1.2
Arm fat percentage (left)	0.9	3.6	6.3	2.4	-1.0	1.0	2.5	-2.0
Average weekly red wine intake	0.3	0.4	1.4	0.4	0.6	-0.4	-1.2	0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	1.0	-0.9	0.6	0.6	0.3
Mood swings	0.2	0.4	0.8	0.5	0.8	0.2	-0.4	0.9
Loneliness, isolation	0.5	0.6	1.5	1.2	1.1	0.3	-0.6	-0.0
Long-standing illness, disability or infirmity	0.3	0.4	0.9	-0.1	0.5	0.6	0.9	-0.9
Ever had bowel cancer screening	0.6	0.7	1.9	0.1	1.0	-0.2	0.9	-1.4
Diabetes diagnosed by doctor	3.6	5.9	10.6	2.1	-2.0	0.2	3.2	-3.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.9	1.7	0.2	0.1	1.3	-1.5
Friendships satisfaction	1.1	1.4	2.3	-1.2	1.1	1.1	-1.5	0.9
Qualifications: nursing, teaching	0.9	1.4	5.3	0.6	-0.6	-0.9	0.6	-2.3
Commuting to job workplace: Walk	1.4	1.6	3.6	-0.6	1.9	-0.3	-1.9	0.6
Eye problems/disorders: Cataract	0.3	0.4	1.3	0.0	-0.6	0.5	0.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.2	0.7	1.1	0.4	0.7	-0.9
Medication for cholesterol	0.2	0.3	0.8	-0.5	-0.0	-0.5	-0.9	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.7	0.6	-0.9	0.2	0.4
Back pain experienced in last month	0.5	0.8	3.6	0.3	1.9	0.3	0.0	-0.1
Mineral and other dietary supplements	1.0	1.3	2.4	-0.9	-1.5	-0.1	-1.1	1.5
Breast cancer (self-reported)	0.3	0.4	0.7	0.3	-0.4	0.7	0.8	-0.8
Asthma (self-reported)	0.3	0.5	1.5	0.9	-0.5	-0.1	1.2	0.1
Osteoporosis (self-reported)	3.1	3.8	7.6	2.3	-0.6	0.4	2.8	-2.4
Osteoarthritis (self-reported)	1.0	1.3	2.7	1.4	-0.3	-0.1	1.3	-1.6
Medication: Aspirin	0.5	0.7	1.3	0.5	-0.3	-0.8	1.2	-1.1
Medication: Gliclazide	3.4	3.8	4.8	2.2	-1.8	1.6	2.0	-2.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.3	-0.5	-0.3	-0.5	-0.6
Smoking status: Current	0.8	1.3	4.5	-2.1	0.5	0.9	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	0.4	1.1	-0.6	-0.0	-1.2
Whole body water mass	0.3	1.9	3.0	0.6	1.5	0.9	-1.7	1.7
Leg predicted mass (right)	0.2	1.2	1.4	0.8	1.1	1.1	-1.2	1.2
Arm fat mass (left)	0.5	1.9	5.2	2.3	0.1	1.3	1.4	-0.8
Number of self-reported non-cancer illnesses	0.3	0.5	0.8	-0.3	0.9	0.8	0.9	-0.4
Average weekly champagne plus white wine intake	0.9	1.3	3.9	0.9	-0.4	2.0	0.4	-1.1
Miserableness	0.5	0.8	2.2	-0.1	1.1	0.4	-0.8	1.5
Guilty feelings	0.1	0.2	0.5	0.7	-0.4	0.3	0.3	-0.3
Wears glasses or contact lenses	0.2	0.2	0.5	-0.5	0.7	-0.2	0.0	-0.4
Ever taken oral contraceptive pill	0.7	0.8	2.7	0.3	-0.9	-1.6	0.7	-0.0
Hearing aid user	0.5	0.6	1.6	-0.4	0.3	0.6	-1.3	0.9
Mother’s age at death	0.9	1.2	4.7	0.5	0.6	2.2	-0.5	-0.5
Financial situation satisfaction	0.1	0.1	0.2	0.1	-0.2	0.2	0.4	-0.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	5.0	-1.2	0.5	0.3	-2.2	1.0
Commuting to job workplace: Public transport	0.2	0.2	0.8	-0.0	0.1	0.9	0.6	-0.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.8	0.0	-1.1	-1.7	0.9	-1.0
Medication: Blood pressure	0.5	0.9	1.7	0.8	0.4	1.2	-0.8	1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.2	-0.3	1.5	-0.3	-0.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.8	-0.2	1.9	-0.2	-0.5	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.3	0.3	-0.5	0.2	0.5	-0.4
Medication: Bendroflumethiazide	1.1	1.6	4.5	-0.1	0.1	1.2	-1.5	2.1
Medication: Paracetamol	0.7	1.0	2.3	0.4	1.0	1.5	1.0	-0.7
Medication: Lisinopril	0.1	0.2	0.3	0.5	0.5	0.5	-0.1	0.2
Medication: Atorvastatin	2.3	2.8	4.7	2.2	-1.5	1.0	2.1	-1.3
Illnesses of father: High blood pressure	0.4	0.5	1.1	-1.1	0.5	-0.5	-0.4	0.7
Alcohol drinker status: Never	0.6	0.7	2.9	0.2	0.2	-1.7	0.4	-0.6
Ever smoked	0.6	1.0	2.1	0.5	1.0	1.4	0.1	1.5
Basal metabolic rate	0.3	1.5	2.0	1.0	1.4	1.1	-1.3	1.4
Leg fat percentage (left)	0.7	2.4	3.8	2.0	0.1	1.1	1.9	-1.9
Arm fat-free mass (left)	0.4	2.1	3.0	0.7	1.7	1.2	-1.6	1.7
Number of operations (self-reported)	1.5	2.2	5.1	1.2	0.4	-1.5	2.2	-1.5
Average weekly beer plus cider intake	0.2	0.2	0.8	-0.5	-0.1	0.2	-0.1	0.9
Irritability	0.2	0.3	0.9	-0.0	0.2	0.9	-0.6	0.2
Risk taking	0.4	0.5	1.2	-0.4	-0.1	1.1	0.7	-0.9
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.1	1.2	-0.1	-1.5	1.1	-1.2
Fractured/broken bones in last 5 years	2.9	3.8	7.4	-0.2	2.5	1.5	-1.6	2.7
Age started oral contraceptive pill	1.9	2.4	3.9	-1.8	1.4	0.2	-2.0	1.7
Diastolic blood pressure, automated reading	0.2	0.5	1.6	0.8	-0.4	-0.2	0.2	1.3
Ever depressed for a whole week	0.4	0.5	0.8	0.8	-0.2	0.7	0.4	-0.9
Unable to work because of sickness or disability	0.3	0.4	1.5	0.3	-0.2	0.1	1.2	-0.5
Commuting to job workplace: Cycle	0.3	0.4	1.6	0.5	0.4	0.0	0.0	-1.3
Myopia	1.0	1.5	3.2	0.8	-1.5	0.8	0.9	-1.8
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.6	-1.3	-1.1	-0.6	-0.6	-0.1
Cholesterol lowering medication	0.2	0.4	0.6	0.3	0.3	0.6	0.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	0.7	-0.8	-0.1	1.3	-1.2
Pain experienced in last month	0.6	1.1	3.7	-0.3	-1.9	-0.5	-0.5	1.0
Supplements: Calcium	0.1	0.2	0.4	-0.2	0.3	0.6	-0.2	-0.5
Basal cell carcinoma (self-reported)	0.4	0.4	1.4	1.2	-0.6	-0.1	0.6	-0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	0.7	-0.0	0.8	1.4	0.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.5	1.4	-1.0	1.9	1.2	-0.9
Heart disease (siblings)	0.7	0.8	2.8	1.7	0.3	-0.5	1.0	0.1
Alcohol drinker status: Previous	0.9	1.1	2.1	0.7	1.4	1.4	0.5	-0.8
Pack years of smoking	0.5	0.8	2.5	0.6	-1.6	0.1	-1.0	0.1
Impedance of whole body	0.3	1.7	3.8	-1.9	-0.3	-1.9	0.3	1.1
Leg fat mass (left)	0.4	1.7	4.6	2.1	0.3	1.1	1.1	-1.2
Arm predicted mass (left)	0.5	2.5	3.8	0.6	1.9	1.4	-1.8	1.7