[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr17:3,011,213-4,966,954

Best TWAS P=1.59e-26 · Best GWAS P=5.14e-27 conditioned to 0.512

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CYB5D2 0.06 0.00 blup 467 0.03 2.6e-04 2.16 7.0 2.2e-12 -0.53 0.28 0.52 FALSE
2 CommonMind Brain Pre-frontal Cortex UBE2G1 0.08 0.10 lasso 8 0.10 1.2e-11 8.10 -8.4 3.2e-17 0.42 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous CYB5D2 0.11 0.06 enet 9 0.09 7.1e-08 5.42 6.7 2.8e-11 -0.48 0.97 0.01 FALSE
4 GTEx Artery Aorta CYB5D2 0.16 0.11 lasso 2 0.10 2.4e-06 5.42 5.4 6.0e-08 -0.45 0.98 0.00 FALSE
5 GTEx Artery Coronary CYB5D2 0.16 0.10 lasso 2 0.07 1.9e-03 5.08 5.3 1.1e-07 -0.42 0.21 0.20 FALSE
6 GTEx Artery Coronary RP11-810M2.2 0.30 0.02 lasso 4 0.02 8.5e-02 7.36 6.2 4.5e-10 -0.22 0.09 0.05 FALSE
7 GTEx Artery Tibial CYB5D2 0.25 0.25 lasso 6 0.24 7.4e-19 5.42 5.3 1.4e-07 -0.43 1.00 0.00 FALSE
8 GTEx Artery Tibial ANKFY1 0.07 0.00 enet 21 0.00 1.6e-01 8.67 6.5 8.3e-11 -0.28 0.23 0.24 FALSE
9 GTEx Brain Nucleus accumbens basal ganglia UBE2G1 0.18 0.05 lasso 3 0.02 7.4e-02 8.05 -7.9 2.0e-15 0.42 0.19 0.14 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia RP11-810M2.2 0.24 0.17 lasso 5 0.10 1.3e-03 8.05 -8.2 3.7e-16 0.46 0.23 0.52 FALSE
11 GTEx Breast Mammary Tissue (Female) ZZEF1 0.11 -0.01 lasso 2 0.00 4.6e-01 8.17 8.2 3.2e-16 -0.41 0.08 0.08 FALSE
12 GTEx Cells Transformed fibroblasts CYB5D2 0.29 0.03 lasso 10 0.09 3.7e-07 1.24 6.3 2.1e-10 -0.51 0.80 0.17 FALSE
13 GTEx Cells Transformed fibroblasts ANKFY1 0.10 0.03 enet 6 0.02 1.1e-02 8.71 -9.9 5.4e-23 0.59 0.65 0.05 FALSE
14 GTEx Colon Transverse CYB5D2 0.14 0.06 enet 8 0.08 1.2e-04 4.60 5.1 3.0e-07 -0.35 0.78 0.04 FALSE
15 GTEx Esophagus Mucosa CYB5D2 0.10 0.04 enet 10 0.06 1.2e-04 5.42 6.1 1.2e-09 -0.43 0.70 0.19 FALSE
16 GTEx Esophagus Muscularis CYB5D2 0.18 0.13 lasso 7 0.13 2.6e-08 4.94 5.6 2.2e-08 -0.42 0.98 0.02 FALSE
17 GTEx Lung ATP2A3 0.28 0.10 lasso 6 0.15 1.8e-11 -10.76 7.7 1.8e-14 -0.87 0.00 1.00 FALSE
18 GTEx Muscle Skeletal ZZEF1 0.11 0.01 lasso 3 0.01 1.9e-02 6.87 7.1 1.1e-12 -0.31 0.39 0.04 FALSE
19 GTEx Nerve Tibial CTD-3195I5.1 0.09 0.00 enet 35 0.02 1.9e-02 9.70 5.2 1.9e-07 -0.38 0.10 0.29 FALSE
20 GTEx Thyroid ZZEF1 0.15 0.06 enet 46 0.09 3.5e-07 6.92 6.6 4.1e-11 -0.21 0.90 0.02 FALSE
21 GTEx Thyroid CYB5D2 0.12 0.09 lasso 3 0.05 1.9e-04 5.42 7.0 2.5e-12 -0.50 0.94 0.04 FALSE
22 METSIM Adipose C17orf85 0.05 0.00 blup 502 0.03 9.1e-05 -0.33 -6.7 2.2e-11 0.24 0.22 0.03 FALSE
23 ROSMAP Brain Pre-frontal Cortex ZZEF1 0.07 0.06 lasso 5 0.06 8.1e-08 9.50 9.6 7.2e-22 -0.49 0.99 0.01 FALSE
24 ROSMAP Brain Pre-frontal Cortex UBE2G1 0.05 0.00 bslmm 487 0.01 5.1e-03 -9.34 -8.0 1.6e-15 0.54 0.04 0.56 FALSE
25 ROSMAP Brain Pre-frontal Cortex ANKFY1 0.05 0.03 enet 11 0.02 1.2e-03 8.71 8.0 1.7e-15 -0.44 0.38 0.02 FALSE
26 YFS Blood UBE2G1 0.02 0.01 enet 12 0.01 5.8e-04 8.17 -7.0 1.8e-12 0.36 0.90 0.00 FALSE
27 YFS Blood ZZEF1 0.06 0.03 enet 13 0.06 2.3e-19 4.59 6.7 2.6e-11 -0.39 1.00 0.00 FALSE
28 The Cancer Genome Atlas Breast Invasive Carcinoma CYB5D2 0.02 0.01 lasso 3 0.02 2.5e-04 4.94 6.1 1.1e-09 -0.44 0.19 0.57 FALSE
29 The Cancer Genome Atlas Colon Adenocarcinoma ATP2A3 0.09 0.08 blup 67 0.07 1.1e-04 9.65 -10.7 1.6e-26 0.67 0.03 0.85 TRUE
30 The Cancer Genome Atlas Colon Adenocarcinoma CYB5D2 0.07 0.07 lasso 1 0.05 5.7e-04 5.42 5.4 6.0e-08 -0.45 0.07 0.36 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma UBE2G1 0.15 0.05 blup 59 0.03 7.5e-03 7.74 6.8 1.4e-11 -0.35 0.10 0.15 FALSE
32 The Cancer Genome Atlas Skin Cutaneous Melanoma ATP2A3 0.24 -0.01 blup 67 0.01 1.3e-01 0.20 5.6 1.9e-08 -0.51 0.01 0.42 FALSE
33 The Cancer Genome Atlas Testicular Germ Cell Tumors ATP2A3 0.32 0.00 enet 22 0.06 5.1e-03 1.46 6.2 6.6e-10 -0.52 0.01 0.36 TRUE