[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr17:3,011,213-4,966,954

Best TWAS P=1.59e-26 · Best GWAS P=5.14e-27 conditioned to 0.512

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CYB5D2	0.06	0.00	blup	467	0.03	2.6e-04	2.16	7.0	2.2e-12	-0.53	0.28	0.52	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UBE2G1	0.08	0.10	lasso	8	0.10	1.2e-11	8.10	-8.4	3.2e-17	0.42	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	CYB5D2	0.11	0.06	enet	9	0.09	7.1e-08	5.42	6.7	2.8e-11	-0.48	0.97	0.01	FALSE
4	GTEx	Artery Aorta	CYB5D2	0.16	0.11	lasso	2	0.10	2.4e-06	5.42	5.4	6.0e-08	-0.45	0.98	0.00	FALSE
5	GTEx	Artery Coronary	CYB5D2	0.16	0.10	lasso	2	0.07	1.9e-03	5.08	5.3	1.1e-07	-0.42	0.21	0.20	FALSE
6	GTEx	Artery Coronary	RP11-810M2.2	0.30	0.02	lasso	4	0.02	8.5e-02	7.36	6.2	4.5e-10	-0.22	0.09	0.05	FALSE
7	GTEx	Artery Tibial	CYB5D2	0.25	0.25	lasso	6	0.24	7.4e-19	5.42	5.3	1.4e-07	-0.43	1.00	0.00	FALSE
8	GTEx	Artery Tibial	ANKFY1	0.07	0.00	enet	21	0.00	1.6e-01	8.67	6.5	8.3e-11	-0.28	0.23	0.24	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	UBE2G1	0.18	0.05	lasso	3	0.02	7.4e-02	8.05	-7.9	2.0e-15	0.42	0.19	0.14	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	RP11-810M2.2	0.24	0.17	lasso	5	0.10	1.3e-03	8.05	-8.2	3.7e-16	0.46	0.23	0.52	FALSE
11	GTEx	Breast Mammary Tissue (Female)	ZZEF1	0.11	-0.01	lasso	2	0.00	4.6e-01	8.17	8.2	3.2e-16	-0.41	0.08	0.08	FALSE
12	GTEx	Cells Transformed fibroblasts	CYB5D2	0.29	0.03	lasso	10	0.09	3.7e-07	1.24	6.3	2.1e-10	-0.51	0.80	0.17	FALSE
13	GTEx	Cells Transformed fibroblasts	ANKFY1	0.10	0.03	enet	6	0.02	1.1e-02	8.71	-9.9	5.4e-23	0.59	0.65	0.05	FALSE
14	GTEx	Colon Transverse	CYB5D2	0.14	0.06	enet	8	0.08	1.2e-04	4.60	5.1	3.0e-07	-0.35	0.78	0.04	FALSE
15	GTEx	Esophagus Mucosa	CYB5D2	0.10	0.04	enet	10	0.06	1.2e-04	5.42	6.1	1.2e-09	-0.43	0.70	0.19	FALSE
16	GTEx	Esophagus Muscularis	CYB5D2	0.18	0.13	lasso	7	0.13	2.6e-08	4.94	5.6	2.2e-08	-0.42	0.98	0.02	FALSE
17	GTEx	Lung	ATP2A3	0.28	0.10	lasso	6	0.15	1.8e-11	-10.76	7.7	1.8e-14	-0.87	0.00	1.00	FALSE
18	GTEx	Muscle Skeletal	ZZEF1	0.11	0.01	lasso	3	0.01	1.9e-02	6.87	7.1	1.1e-12	-0.31	0.39	0.04	FALSE
19	GTEx	Nerve Tibial	CTD-3195I5.1	0.09	0.00	enet	35	0.02	1.9e-02	9.70	5.2	1.9e-07	-0.38	0.10	0.29	FALSE
20	GTEx	Thyroid	ZZEF1	0.15	0.06	enet	46	0.09	3.5e-07	6.92	6.6	4.1e-11	-0.21	0.90	0.02	FALSE
21	GTEx	Thyroid	CYB5D2	0.12	0.09	lasso	3	0.05	1.9e-04	5.42	7.0	2.5e-12	-0.50	0.94	0.04	FALSE
22	METSIM	Adipose	C17orf85	0.05	0.00	blup	502	0.03	9.1e-05	-0.33	-6.7	2.2e-11	0.24	0.22	0.03	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	ZZEF1	0.07	0.06	lasso	5	0.06	8.1e-08	9.50	9.6	7.2e-22	-0.49	0.99	0.01	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	UBE2G1	0.05	0.00	bslmm	487	0.01	5.1e-03	-9.34	-8.0	1.6e-15	0.54	0.04	0.56	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	ANKFY1	0.05	0.03	enet	11	0.02	1.2e-03	8.71	8.0	1.7e-15	-0.44	0.38	0.02	FALSE
26	YFS	Blood	UBE2G1	0.02	0.01	enet	12	0.01	5.8e-04	8.17	-7.0	1.8e-12	0.36	0.90	0.00	FALSE
27	YFS	Blood	ZZEF1	0.06	0.03	enet	13	0.06	2.3e-19	4.59	6.7	2.6e-11	-0.39	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYB5D2	0.02	0.01	lasso	3	0.02	2.5e-04	4.94	6.1	1.1e-09	-0.44	0.19	0.57	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	ATP2A3	0.09	0.08	blup	67	0.07	1.1e-04	9.65	-10.7	1.6e-26	0.67	0.03	0.85	TRUE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	CYB5D2	0.07	0.07	lasso	1	0.05	5.7e-04	5.42	5.4	6.0e-08	-0.45	0.07	0.36	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	UBE2G1	0.15	0.05	blup	59	0.03	7.5e-03	7.74	6.8	1.4e-11	-0.35	0.10	0.15	FALSE
32	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ATP2A3	0.24	-0.01	blup	67	0.01	1.3e-01	0.20	5.6	1.9e-08	-0.51	0.01	0.42	FALSE
33	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ATP2A3	0.32	0.00	enet	22	0.06	5.1e-03	1.46	6.2	6.6e-10	-0.52	0.01	0.36	TRUE