Hub : Genes

UBE2G1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0790	0.0230	8.2e-09	0.103	0.065	0.089	0.078	0.095	1.8e-12	2.6e-08	5.9e-11	9.4e-10	1.2e-11
2	GTEx	Brain Nucleus accumbens basal ganglia	0.1760	0.0820	4.2e-03	0.053	NA	0.003	NA	0.024	1.6e-02	NA	2.6e-01	NA	7.4e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.0511	0.0263	1.0e-02	0.002	0.013	-0.002	0.014	-0.002	1.5e-01	8.2e-03	6.8e-01	5.1e-03	8.4e-01
4	YFS	Blood	0.0167	0.0084	1.8e-03	0.012	0.007	0.009	0.007	0.008	5.0e-05	1.8e-03	5.8e-04	1.2e-03	1.0e-03
5	TCGA	Colon Adenocarcinoma	0.1540	0.0900	1.5e-03	0.051	0.030	0.025	NA	0.015	6.4e-04	7.4e-03	1.3e-02	NA	4.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.8	2.8	5.3	-1.6	-1.4	-2.3	-1.9	0.7
Bipolar Disorder or Schizophrenia	1.9	4.7	6.6	-2.4	-2.6	-1.5	-2.5	1.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.3	0.1	0.6	0.4	0.5
Depression (Nagel 2018)	2.1	3.2	7.5	1.4	1.6	1.6	2.7	-1.3
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.6	-0.6	-0.5	-1.6	-0.6	-0.5
Neuroticism (Nagel 2018)	0.3	0.7	1.6	0.7	1.0	0.4	1.2	-0.3
Schizophrenia (2018)	1.2	2.5	4.6	-1.7	-2.1	-0.1	-1.7	1.5
Schizophrenia vs Biploar Disorder	1.6	2.1	5.3	-0.9	-1.1	2.3	-0.6	1.7
Worry (Nagel 2018)	0.6	1.2	2.3	1.2	1.5	-0.0	1.3	-1.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.1	0.3	-0.3	0.6	-0.4
Alzheimer’s Disease (in father)	3.0	3.3	7.7	-1.4	-1.5	-2.8	-2.0	0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.6	0.0	0.2	-1.3	-0.3	-0.7
Crohns Disease (2017)	0.4	0.8	3.5	-0.5	-0.2	-1.9	-0.5	0.2
Irritable Bowel Disease (IBD)	0.5	1.1	2.0	0.8	1.2	1.1	1.4	-0.4
Ulcerative Colitis (UC)	2.0	3.7	10.1	1.3	1.6	3.2	2.0	-0.5
Major Depression (MDD)	0.4	0.4	0.7	0.6	0.8	0.8	0.0	-0.7
Reaction Time	2.6	4.9	7.6	-2.4	-2.6	-1.2	-1.7	2.8
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.5	-1.5	-1.1	-2.1	-1.7	0.9
Breast Cancer	0.4	0.9	1.2	1.1	1.1	1.1	0.8	-0.1
Ovarian Cancer	1.1	1.5	5.6	-0.4	-0.5	-2.4	-1.0	0.5
Prostate Cancer	0.2	0.3	0.5	0.7	0.5	0.6	0.4	0.1
Age at First Birth	0.0	0.0	0.1	0.1	0.1	0.3	-0.3	0.0
Bipolar Disorder (2011)	0.1	0.1	0.4	0.0	0.0	0.0	0.0	-0.6
Body Mass Index (BMI) (2010)	0.6	0.8	2.3	-0.7	-1.0	-0.6	-1.5	0.3
Coronary Artery Disease (CAD)	0.1	0.2	0.9	0.0	0.0	0.0	0.0	0.9
Crohns Disease (2012)	1.2	2.0	2.5	-1.6	-1.4	-1.4	-1.4	1.1
Mean Putamen Volume	1.2	1.4	2.4	-1.2	-1.4	0.2	-1.1	1.6
Fasting Glucose	0.1	0.2	0.4	-0.1	-0.1	-0.6	0.1	0.6
HbA1C	1.6	1.7	3.0	-1.2	-1.7	-1.5	-1.2	0.7
HDL Cholesterol	0.9	1.5	4.9	1.0	0.8	2.2	0.9	-0.6
LDL Cholesterol	1.9	3.0	4.6	-1.6	-1.6	-2.1	-1.6	1.6
Lupus	0.4	0.6	2.8	-0.1	0.1	1.7	0.6	-0.0
Neuroticism (2016)	1.0	1.4	2.3	-1.4	-0.9	0.5	-1.3	1.5
Primary Biliary Cirrhosis	0.3	0.5	2.0	-0.3	-0.4	1.4	-0.1	0.2
Rheumatoid Arthritis	3.0	4.2	12.1	1.6	1.6	3.5	1.4	-1.3
Schizophrenia (2014)	1.7	3.7	6.1	-2.1	-2.5	0.3	-2.0	1.9
Triglycerides	0.2	0.4	0.5	0.6	0.6	-0.7	0.6	-0.6
Type 2 Diabetes (T2D) (2012)	1.7	1.9	3.2	-0.8	-1.3	-1.5	-1.3	1.8
Ulcerative Colitis	2.0	2.8	8.0	1.1	1.5	2.8	1.6	-0.5
Blood Eosinophil Count	0.2	1.6	3.4	-0.1	-1.7	-1.2	-1.9	0.7
Blood Platelet Count	1.3	15.0	20.8	4.6	4.2	1.9	3.8	-4.3
Blood Red Count	0.1	0.8	1.7	0.7	1.1	-1.3	0.6	0.0
Blood White Count	0.6	4.7	7.8	2.8	2.1	-0.0	2.8	-1.9
Heel T-Score	1.6	12.8	17.5	-4.2	-3.8	-2.8	-3.7	3.2
BMI	2.0	11.9	14.1	-3.4	-3.3	-3.8	-3.7	3.0
Height	0.1	1.3	3.8	-1.1	-0.9	0.4	-0.7	2.0
Waist Hip Ratio (WHR)	4.7	21.1	28.2	-5.1	-5.3	-2.6	-4.7	4.8
Systolic Blood Pressure	0.5	2.3	3.9	-1.4	-1.3	-2.0	-1.6	1.1
Smoking Status	0.1	0.1	0.3	-0.1	-0.4	-0.6	0.1	0.4
Allergy or Eczema	0.4	1.1	4.9	-0.1	-0.3	-2.2	-0.5	-0.3
Cardiovascular Disease	2.6	8.7	10.6	-2.7	-2.7	-3.3	-2.9	3.1
Hypothyroidism (self reported)	1.6	3.7	7.2	2.3	2.2	-0.1	2.7	-1.0
Respiratory disease	0.8	1.9	3.3	1.5	1.2	0.8	1.8	-1.3
Type 2 Diabetes (T2D) (2018)	9.2	17.1	21.0	-4.0	-4.1	-3.6	-4.3	4.6
Lung FEV1/FVC ratio	11.6	58.6	71.2	-8.4	-7.9	-8.0	-7.0	6.8
Lung FVC	1.9	9.8	12.7	3.3	3.3	3.6	3.3	-1.9
Neuroticism	0.6	1.4	3.2	1.1	1.4	-0.5	1.8	-0.6
Chronotype (morning person)	2.8	6.6	10.4	-2.5	-2.4	-0.6	-3.2	3.2
Hair Pigment	0.0	0.5	1.2	0.8	1.1	-0.7	0.4	-0.4
Tanning	0.0	0.1	0.4	-0.1	0.3	-0.4	0.6	-0.2
Hand grip strength (left)	1.3	3.5	6.1	2.4	2.5	1.1	1.4	-1.7
Number of treatments/medications taken	0.3	0.5	2.2	-0.3	-0.4	-0.3	0.1	1.5
Average weekly spirits intake	2.1	2.6	3.6	1.9	1.7	0.8	1.6	-1.7
Sensitivity / hurt feelings	0.3	0.5	1.3	-0.3	-0.3	-1.1	0.6	0.7
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.6	1.5	1.5	0.6	2.1	-1.2
Hearing difficulty/problems: Yes	0.1	0.1	0.5	-0.2	0.0	-0.1	0.7	0.4
Relative age of first facial hair	1.1	2.2	6.7	1.1	1.2	0.3	1.2	-2.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.2	0.3	0.4	-0.4	1.1	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	0.5	0.4	-0.2	0.6	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.6	0.1	0.0	-0.1	-0.2	0.8
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.4	-0.7	-0.5	-0.4	0.5
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.1	-1.3	-1.4	-1.8	-0.6	1.1
Angina	0.2	0.3	0.4	0.5	0.6	-0.5	0.7	-0.0
Medication for hormone replacement therapy	1.0	1.1	2.0	1.0	1.1	-1.4	1.0	-0.7
Vitamin and mineral supplements	0.4	0.5	1.8	0.3	0.5	-1.3	-0.2	-0.6
Supplements: Zinc	0.5	0.5	1.2	0.7	0.5	0.6	0.5	-1.1
Medication: Co-codamol	1.2	1.4	2.4	1.0	1.1	-0.9	1.6	-1.0
Medication: Metformin	3.3	4.7	7.1	-1.8	-1.8	-2.5	-2.7	2.0
Diabetes (father)	1.8	2.3	4.1	-1.8	-1.9	-2.0	-0.7	0.4
Diabetes (mother)	5.7	7.2	9.0	-2.8	-3.0	-2.1	-2.5	3.0
Severe depression (siblings)	0.3	0.3	0.6	0.6	0.7	-0.0	0.8	-0.2
Pack years adult smoking proportion	0.3	0.4	1.3	-0.7	-0.5	-1.1	-0.3	0.3
Impedance of leg (right)	0.6	2.7	7.2	-1.6	-1.7	0.4	-0.7	2.7
Leg fat-free mass (left)	0.3	1.6	3.0	-1.0	-1.0	-1.4	-1.7	1.0
Trunk fat percentage	2.1	8.5	11.1	-2.9	-3.2	-2.2	-2.9	3.3
Hand grip strength (right)	0.9	2.5	4.0	2.0	2.0	0.1	1.0	-1.9
Townsend deprivation index at recruitment	0.5	0.7	1.4	1.0	1.2	0.7	0.3	-0.6
Current tobacco smoking	0.5	0.8	3.5	-0.1	-0.4	-1.9	0.4	-0.3
Average weekly fortified wine intake	0.9	1.1	4.1	-0.4	-0.4	-2.0	-0.9	0.2
Maternal smoking around birth	0.3	0.5	1.2	0.1	0.5	0.6	1.1	-0.7
Fed-up feelings	0.1	0.2	0.8	0.2	0.4	0.1	0.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	0.7	0.8	0.7	1.4	-0.4
Relative age voice broke	0.8	1.2	3.5	0.2	0.2	-1.6	-0.1	-1.9
Taking other prescription medications	0.8	1.2	2.5	0.9	0.9	1.3	1.6	0.2
Age when periods started (menarche)	0.2	0.4	1.2	0.6	0.7	1.1	0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	0.7	0.6	0.8	1.2	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.4	-0.8	-0.9	1.2	-1.2	1.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	-0.3	-0.6	-0.5	0.2
Qualifications: CSEs or equivalent	0.4	0.5	1.3	0.5	0.7	-0.3	0.6	-1.1
Serious illness, injury or assault to yourself	0.8	0.9	1.4	1.0	1.2	1.0	0.9	-0.6
High blood pressure	2.1	5.8	6.7	-2.6	-2.6	-1.6	-2.5	2.6
Hayfever, allergic rhinitis or eczema	0.8	1.8	5.9	-0.8	-1.0	-2.4	-1.2	0.0
Multivitamins +/- minerals	0.0	0.1	0.1	-0.2	-0.4	0.3	0.1	0.0
Stomach or abdominal pain in last month	0.4	0.5	2.2	-0.0	-0.1	-1.5	0.5	0.4
Supplements: Glucosamine	0.1	0.2	0.4	0.6	0.6	0.2	0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.3	-0.0	0.5	0.4	0.6
Medication: Atenolol	1.0	1.3	1.8	-1.2	-1.2	1.0	-0.9	1.3
Medication: Levothyroxine sodium	1.2	2.1	3.5	1.6	1.9	-0.2	1.8	-1.1
Sitting height	0.1	0.7	1.7	-0.4	-0.7	0.8	-0.9	1.3
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	-0.7	-0.8	0.2	-0.2	0.0
High blood pressure (mother)	0.5	0.7	1.5	-0.8	-0.8	-0.6	-0.7	1.2
Body mass index (BMI)	1.2	4.9	7.7	-2.0	-2.0	-2.8	-2.3	1.8
Impedance of leg (left)	0.5	2.3	5.8	-1.5	-1.7	0.8	-0.6	2.4
Leg predicted mass (left)	0.3	1.5	2.9	-1.0	-0.9	-1.4	-1.7	0.9
Trunk fat mass	2.0	8.7	10.4	-2.9	-3.2	-2.2	-3.1	3.2
Waist circumference	2.5	9.0	10.4	-3.1	-3.2	-2.2	-3.1	3.2
Number of incorrect matches in round	0.9	1.4	4.4	0.7	0.8	2.1	1.0	0.9
Past tobacco smoking	0.5	0.8	3.2	-0.6	-0.4	-1.8	-0.7	-0.1
Alcohol usually taken with meals	0.3	0.5	1.5	0.5	0.4	1.2	0.9	-0.2
Nervous feelings	1.1	2.1	3.2	1.7	1.7	0.8	1.8	-1.0
Frequency of tenseness / restlessness in last 2 weeks	3.4	5.2	8.6	2.4	2.3	1.3	2.9	-2.2
Hearing difficulty/problems with background noise	0.2	0.2	1.0	0.1	0.4	1.0	0.1	0.2
Hair/balding pattern: Pattern 2	0.9	1.2	2.5	1.1	1.1	-0.6	1.6	-0.8
Had menopause	0.6	0.8	2.2	-0.8	-0.7	0.9	0.1	1.5
Had other major operations	0.5	0.6	1.7	-0.4	-0.5	-1.3	0.6	0.7
Forced vital capacity (FVC)	0.5	1.8	2.5	1.6	1.6	1.3	1.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.3	-1.2	-1.3	0.7	-1.4	1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.7	-0.6	-0.7	-1.7	-0.2	0.1
Qualifications: None of the above	0.9	1.8	6.2	0.9	0.8	2.5	1.2	-0.1
Financial difficulties in last 2 years	0.4	0.6	1.2	0.7	0.5	0.9	1.1	-0.3
Mouth/teeth dental problems	0.3	0.4	0.9	-0.7	-1.0	-0.5	-0.5	-0.5
Heart attack	0.6	0.7	1.1	-0.7	-0.7	-0.8	-1.0	0.9
Allergy	0.4	0.9	3.3	-0.3	-0.2	1.8	0.3	1.0
Pain all over the body in last month	1.6	1.7	3.3	1.4	1.4	-0.5	1.8	-1.1
Diabetes (self-reported)	5.7	8.9	11.5	-3.1	-3.0	-1.8	-3.4	3.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-0.4	-0.3	0.2	-0.9	0.8
Medication: Ramipril	5.9	7.6	8.5	-2.9	-2.9	-2.6	-2.9	2.5
Medication: Simvastatin	0.1	0.2	0.4	-0.2	-0.2	-0.6	-0.4	0.6
Fluid intelligence score	0.7	1.4	5.1	-0.8	-0.7	-2.3	-0.9	0.1
Illnesses of siblings	0.4	0.5	0.9	-1.0	-0.8	-0.8	-0.6	-0.2
Neuroticism score	0.6	1.2	2.1	1.1	1.4	-0.5	1.5	-0.6
Weight	1.5	7.5	10.2	-2.7	-2.8	-2.1	-3.2	2.9
Impedance of arm (right)	0.2	0.7	2.8	0.4	0.1	1.7	0.8	0.1
Arm fat percentage (right)	1.1	4.4	6.1	-1.9	-2.0	-2.5	-2.1	2.0
Trunk fat-free mass	0.5	2.7	5.3	-1.5	-1.5	-1.2	-2.3	1.5
Hip circumference	0.8	3.5	4.7	-1.6	-1.7	-1.9	-2.2	1.9
Time employed in main current job	0.5	0.6	2.2	-0.1	-0.4	1.5	-0.3	0.8
Alcohol intake versus 10 years previously	0.6	0.9	2.8	-0.9	-0.7	-0.4	-0.4	1.7
Father’s age at death	0.6	0.8	1.7	0.6	0.5	1.3	1.1	-0.5
Worrier / anxious feelings	0.4	0.8	1.3	0.9	1.1	-0.4	1.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	6.4	2.4	2.5	0.8	2.3	-2.0
Falls in the last year	0.8	1.1	1.6	1.3	1.1	1.2	1.0	-0.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.6	0.7	1.1	1.6	0.7	-1.0
Number of live births	3.6	5.1	8.4	-2.5	-2.6	-1.2	-1.7	2.9
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.6	-0.4	-0.2	-1.3	-0.1	0.4
Pulse rate	1.1	1.8	2.7	-1.5	-1.4	-1.6	-1.1	0.9
Happiness	0.4	0.4	1.0	-0.6	-0.3	-0.7	-0.5	1.0
Noisy workplace	2.5	3.1	4.6	-2.0	-1.9	-0.5	-1.7	2.1
Qualifications: A levels/AS levels or equivalent	2.2	4.8	8.3	-2.1	-1.9	-1.3	-2.9	2.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.6	-0.5	-0.2	-1.3	-0.2	-0.1
Mouth/teeth dental problems: Dentures	2.3	3.8	5.4	2.1	2.3	1.6	2.3	-1.1
Asthma	0.6	1.3	1.7	1.3	1.2	0.6	1.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	5.3	6.7	9.4	2.8	3.1	1.4	2.7	-2.7
Medication: Cholesterol lowering	0.3	0.4	1.6	-0.1	-0.1	-1.3	0.5	-0.3
Depression (self-reported)	0.5	0.5	1.0	1.0	0.8	-0.4	0.9	-0.5
Medication: Lansoprazole	0.6	0.7	1.5	1.2	1.1	0.6	0.7	-0.5
Prospective memory result	0.4	0.5	1.6	0.2	-0.2	1.3	-0.6	0.8
Lung cancer (father)	0.1	0.2	0.3	-0.6	-0.4	-0.0	-0.5	-0.2
Illnesses of mother	0.2	0.2	1.0	0.1	0.3	0.3	-0.0	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.3	-0.9	-0.8	-1.0	-0.8	1.1
Pulse wave Arterial Stiffness index	1.3	1.5	3.1	-1.5	-1.8	0.3	-1.2	0.7
Impedance of arm (left)	0.3	1.3	3.2	0.9	0.6	1.8	1.4	-0.1
Arm fat mass (right)	1.7	7.0	7.7	-2.5	-2.6	-2.7	-2.8	2.5
Trunk predicted mass	0.4	2.5	5.1	-1.4	-1.4	-1.2	-2.2	1.5
Standing height	0.4	4.1	7.5	-1.9	-2.1	0.9	-2.1	2.7
Length of working week for main job	0.1	0.1	0.5	-0.1	0.1	0.7	-0.0	-0.2
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.6	-0.4	-0.3	0.2	0.9
Breastfed as a baby	0.2	0.2	0.4	-0.5	-0.4	0.6	-0.6	0.0
Tense / ‘highly strung’	1.4	2.4	4.2	1.7	2.0	-0.2	1.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.2	1.4	1.4	-0.5	1.5	-1.0
Hair/balding pattern: Pattern 4	0.6	1.5	4.1	-0.4	-0.9	1.0	-1.1	2.0
Birth weight of first child	0.2	0.4	0.9	-0.8	-1.0	-0.6	0.2	0.6
Peak expiratory flow (PEF)	0.4	1.0	3.5	0.3	0.7	-1.9	0.8	-0.6
Pulse wave reflection index	0.1	0.2	0.6	-0.4	-0.8	-0.2	-0.2	0.1
Ever highly irritable/argumentative for 2 days	0.6	0.8	3.6	-0.3	-0.4	-1.9	0.0	0.1
Loud music exposure frequency	0.2	0.2	0.4	0.4	0.7	0.4	0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.7	-1.0	-0.6	-1.9	-0.9	0.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.7	-1.1	-0.9	-0.6	-1.0	1.6
Blood clot in the leg (DVT)	0.4	0.6	0.9	-0.7	-0.7	-0.9	-0.6	0.8
Medication: Paracetamol	3.5	5.9	8.1	2.5	2.8	2.3	2.6	-1.6
Headache pain in last month	0.3	0.5	1.6	-0.5	-0.5	0.2	-0.6	1.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.5	1.1	1.1	1.6	-0.0	-0.9
Glaucoma (self-reported)	0.3	0.3	1.3	-0.2	-0.5	1.1	-0.1	0.4
Gout (self-reported)	1.6	2.2	4.8	1.0	1.1	2.2	1.6	-1.3
Hypothyroidism/myxoedema (self-reported)	2.6	5.0	7.8	2.7	2.7	0.3	2.8	-1.6
Medication: Amlodipine	5.3	7.5	11.3	-2.7	-2.7	-1.9	-2.7	3.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	0.5	0.3	1.1	0.5	0.5
Birth weight	3.8	8.3	12.2	-3.1	-3.3	-0.6	-3.5	2.9
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.0	1.6	2.0	-0.2	1.6	-1.2
High blood pressure (siblings)	0.8	1.1	3.0	-0.7	-0.7	0.2	-1.7	1.3
Forced vital capacity (FVC), Best measure	0.4	1.6	3.5	1.4	1.3	1.9	1.1	-0.3
Body fat percentage	2.3	9.1	11.1	-3.0	-3.2	-2.5	-3.0	3.3
Leg fat percentage (right)	2.9	10.6	11.8	-3.3	-3.4	-3.0	-3.1	3.4
Arm fat-free mass (right)	0.8	4.2	6.6	-1.9	-1.9	-1.8	-2.6	2.0
Exposure to tobacco smoke outside home	0.5	0.7	1.1	1.1	1.0	-0.5	0.5	-0.9
Comparative body size at age 10	1.6	4.4	7.2	-2.5	-2.3	0.2	-1.7	2.7
Number of full brothers	0.8	1.0	1.8	-0.7	-0.8	0.3	-1.4	1.3
Worry too long after embarrassment	0.1	0.1	0.2	0.1	0.5	-0.4	0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.8	0.9	1.1	-0.1	1.7	-0.1
Wheeze or whistling in the chest in last year	0.6	1.1	2.0	-1.0	-1.4	0.3	-0.5	1.4
Number of children fathered	0.2	0.2	0.6	0.2	0.1	0.7	0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	4.4	-1.1	-1.0	-2.1	-1.7	-0.0
Age at first live birth	0.3	0.6	2.4	-0.6	-0.4	0.1	-1.6	-0.3
Pulse wave peak to peak time	1.1	1.3	2.7	1.4	1.7	-0.1	1.1	-0.5
Health satisfaction	0.4	0.6	1.5	0.2	0.1	1.2	0.0	1.1
Shortness of breath walking on level ground	0.3	0.4	1.5	-0.2	-0.4	0.3	-0.6	1.2
Qualifications: College or University degree	1.1	3.4	5.4	-2.2	-2.3	-0.4	-1.9	1.7
Eye problems/disorders: None of the above	0.2	0.2	0.6	0.2	0.4	0.1	-0.4	-0.8
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.0	-1.1	-0.8	0.2	-0.9	1.4
Emphysema/chronic bronchitis	0.9	1.0	2.4	1.0	0.7	1.6	0.9	-0.2
Medication for pain relief, constipation, heartburn	2.2	3.7	5.7	-1.9	-2.2	-2.1	-2.4	0.6
Neck or shoulder pain in last month	0.4	0.6	1.2	0.4	0.4	1.1	1.0	0.4
Medication: Blood pressure	1.0	1.7	3.5	-1.3	-1.3	-1.9	-0.6	1.1
Angina (self-reported)	0.6	0.7	1.4	1.0	1.1	-0.1	1.2	-0.4
Migraine (self-reported)	0.2	0.3	0.7	-0.4	-0.4	0.4	-0.3	0.9
Medication: Ibuprofen	3.8	4.5	6.9	2.3	2.6	0.3	2.0	-2.5
Medication: Allopurinol	0.6	0.9	2.8	0.3	0.5	1.7	0.9	-0.6
Medication: Omeprazole	0.4	0.5	1.4	0.4	0.4	0.6	0.8	1.2
Medication: Seretide 50 evohaler	0.5	0.5	2.5	0.1	-0.1	1.6	0.3	0.1
Mean time to correctly identify matches	2.4	4.6	7.4	-2.5	-2.5	-0.9	-1.6	2.7
Heart disease (mother)	0.3	0.4	0.6	0.8	0.5	0.7	0.8	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	5.6	1.7	2.3	-0.1	1.2	-2.4
Whole body fat mass	2.2	9.2	10.4	-3.0	-3.2	-2.6	-3.2	3.2
Leg fat mass (right)	2.7	10.4	11.5	-3.2	-3.3	-3.0	-3.4	3.3
Arm predicted mass (right)	0.9	4.4	6.8	-2.0	-2.0	-1.7	-2.6	2.0
Pulse rate, automated reading	0.9	2.9	4.8	-2.1	-2.2	-1.1	-1.3	1.5
Alcohol intake frequency.	0.2	0.5	1.9	0.4	0.4	-0.6	1.4	-0.1
Comparative height size at age 10	0.6	3.0	4.9	-1.7	-1.6	0.4	-2.2	2.1
Number of full sisters	0.7	0.8	2.4	0.7	0.3	1.6	0.9	-0.5
Suffer from ‘nerves’	0.1	0.2	0.7	0.0	0.1	-0.9	0.2	0.1
Overall health rating	0.9	1.9	5.3	1.0	0.8	2.3	1.5	0.7
Chest pain or discomfort	0.6	0.9	3.2	0.6	0.3	1.8	0.5	0.7
Had major operations	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.2	0.1
Age at last live birth	0.2	0.2	0.6	-0.4	-0.4	-0.5	-0.8	-0.3
Family relationship satisfaction	0.2	0.3	0.6	-0.3	-0.3	-0.8	-0.6	0.4
Leg pain on walking	1.7	2.1	3.4	-1.6	-1.9	-0.4	-1.1	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	7.9	-1.2	-1.1	-2.8	-0.7	0.6
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	-0.0	0.0	0.1	0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.0	0.2	0.1	-0.3	-0.3
Medication: Aspirin	1.5	2.0	3.0	-1.4	-1.6	0.0	-1.5	1.7
Supplements: Vitamin C	1.1	1.3	2.0	-1.2	-1.4	0.4	-0.9	1.4
Knee pain experienced in last month	0.4	0.6	1.0	-1.0	-0.9	-0.3	-0.8	0.6
Hypertension (Self-reported)	2.7	7.5	9.3	-2.9	-2.9	-1.8	-3.1	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	0.7	0.8	1.1	0.1	-0.9
Illnesses of father: Heart disease	2.3	3.2	5.2	1.9	1.9	2.3	1.9	-0.6
Illnesses of siblings: Diabetes	1.6	2.0	2.6	-1.5	-1.6	-1.3	-1.1	1.5
Smoking status: Previous	0.8	1.2	5.0	0.6	0.5	2.2	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	-0.1	-0.2	0.1	-0.3	0.4
Whole body fat-free mass	0.5	2.6	5.1	-1.4	-1.4	-1.4	-2.2	1.4
Leg fat-free mass (right)	0.2	1.1	2.5	-0.8	-0.8	-1.1	-1.6	0.7
Arm fat percentage (left)	1.0	3.9	6.4	-1.7	-1.9	-2.5	-1.9	1.9
Average weekly red wine intake	0.1	0.1	0.4	0.3	-0.1	-0.4	-0.1	-0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.4	0.4	-0.9	0.4	-0.8
Mood swings	0.1	0.1	0.3	-0.4	-0.1	-0.1	-0.3	0.5
Loneliness, isolation	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.3	0.5
Long-standing illness, disability or infirmity	0.9	1.3	2.1	-1.3	-0.8	-1.4	-0.2	1.4
Ever had bowel cancer screening	0.7	0.8	2.8	-0.2	-0.2	1.7	0.7	0.8
Diabetes diagnosed by doctor	5.9	9.7	11.8	-3.4	-3.1	-2.5	-3.0	3.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.7	0.9	0.8	-0.3	0.6	-1.3
Friendships satisfaction	0.7	0.9	2.2	-0.7	-0.5	-1.5	-1.2	0.3
Qualifications: nursing, teaching	1.2	1.9	2.9	-1.7	-1.3	-1.0	-1.3	1.4
Commuting to job workplace: Walk	0.2	0.2	0.6	0.5	0.4	0.8	0.2	0.1
Eye problems/disorders: Cataract	0.8	0.9	1.2	1.1	1.0	0.3	1.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.2	-0.0	-0.7	-0.4	0.2
Medication for cholesterol	2.7	4.1	5.8	1.8	1.7	1.9	2.4	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	0.2	0.4	0.9	1.0	-0.2
Back pain experienced in last month	0.5	0.7	1.8	-0.7	-0.5	-0.3	-1.0	1.3
Mineral and other dietary supplements	1.5	2.0	3.0	1.6	1.7	-0.4	1.3	-1.7
Breast cancer (self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.3	0.1	-0.5
Asthma (self-reported)	0.6	1.2	1.7	1.3	1.1	0.5	1.1	-1.2
Osteoporosis (self-reported)	0.3	0.4	0.7	0.6	0.7	0.8	0.4	0.3
Osteoarthritis (self-reported)	0.4	0.5	2.5	0.1	-0.2	0.1	-0.1	1.6
Medication: Aspirin	2.4	3.2	4.1	-1.9	-2.0	-0.6	-2.0	2.0
Medication: Gliclazide	2.0	2.2	2.9	-1.5	-1.6	-0.9	-1.7	1.6
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.1	-0.0	0.3	-0.2	-0.2
Smoking status: Current	0.6	1.0	4.5	-0.1	-0.5	-2.1	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	9.6	-2.1	-1.5	-3.1	-2.0	1.7
Whole body water mass	0.4	2.4	4.8	-1.4	-1.4	-1.3	-2.2	1.4
Leg predicted mass (right)	0.2	0.9	2.1	-0.7	-0.7	-1.1	-1.4	0.6
Arm fat mass (left)	1.7	7.1	7.6	-2.5	-2.6	-2.7	-2.8	2.7
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	-0.0	-0.1	0.1	0.7	0.9
Average weekly champagne plus white wine intake	0.1	0.2	0.8	-0.3	-0.1	0.2	-0.9	0.2
Miserableness	0.9	1.5	2.4	1.5	1.4	0.5	1.6	-0.8
Guilty feelings	0.2	0.3	0.5	0.4	0.7	-0.5	-0.0	-0.7
Wears glasses or contact lenses	0.2	0.3	0.6	-0.3	-0.2	0.8	-0.6	0.5
Ever taken oral contraceptive pill	0.2	0.3	0.4	-0.6	-0.6	0.5	-0.0	0.5
Hearing aid user	0.2	0.2	0.8	-0.3	-0.2	0.9	-0.6	0.1
Mother’s age at death	0.7	0.9	1.5	1.2	1.1	1.2	0.5	-0.3
Financial situation satisfaction	1.7	2.1	3.7	1.6	1.9	-0.1	1.4	-1.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.5	0.8	0.5	1.9	0.3	-0.1
Commuting to job workplace: Public transport	0.8	1.0	1.8	1.2	1.0	1.3	0.0	-1.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.7	-0.4	-0.8	1.3	-0.2	0.2
Medication: Blood pressure	4.7	9.0	15.6	-2.8	-3.0	-1.0	-4.0	3.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.1	-0.3	0.7	-0.2	0.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.4	-1.5	-1.7	1.0	-1.2	1.9
High cholesterol (Self-reported)	0.0	0.1	0.1	0.2	0.1	-0.2	0.3	-0.3
Medication: Bendroflumethiazide	1.4	2.1	4.5	-1.1	-1.4	-1.6	-0.7	2.1
Medication: Paracetamol	2.3	3.6	5.1	2.1	2.3	1.7	1.8	-1.5
Medication: Lisinopril	0.9	1.1	1.8	-0.9	-1.1	-1.3	-0.6	1.1
Medication: Atorvastatin	1.2	1.5	2.1	-1.3	-1.1	-1.5	-1.3	0.9
Illnesses of father: High blood pressure	1.1	1.3	2.8	0.7	1.2	-1.7	0.8	-1.1
Alcohol drinker status: Never	3.1	3.7	5.0	2.2	2.2	-0.2	2.0	-2.2
Ever smoked	0.1	0.3	1.2	0.1	-0.1	1.1	0.1	-0.1
Basal metabolic rate	0.7	3.8	6.5	-1.8	-1.8	-1.6	-2.5	1.8
Leg fat percentage (left)	2.5	8.9	10.2	-3.1	-3.2	-2.8	-2.9	3.0
Arm fat-free mass (left)	0.9	4.5	7.3	-2.0	-2.0	-1.5	-2.7	2.1
Number of operations (self-reported)	1.1	1.6	3.1	1.4	1.4	0.6	1.8	-0.9
Average weekly beer plus cider intake	0.2	0.2	0.7	0.4	0.4	-0.4	-0.8	0.0
Irritability	3.7	6.2	9.8	2.9	3.1	1.0	2.8	-2.1
Risk taking	1.6	2.3	8.1	-0.9	-0.9	-2.9	-1.2	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	-0.8	-0.9	-0.5	-1.1	1.0
Fractured/broken bones in last 5 years	0.0	0.1	0.1	-0.1	-0.4	-0.3	0.2	0.2
Age started oral contraceptive pill	2.2	2.7	10.6	-0.3	-0.4	3.3	-0.7	1.5
Diastolic blood pressure, automated reading	4.3	13.3	16.1	-3.9	-3.8	-4.0	-3.2	3.4
Ever depressed for a whole week	1.8	2.2	9.6	-0.7	-0.9	-3.1	-0.1	0.5
Unable to work because of sickness or disability	2.2	2.8	4.4	1.9	2.1	-0.7	1.6	-1.7
Commuting to job workplace: Cycle	0.2	0.2	1.0	-0.2	-0.1	-0.1	-1.0	0.0
Myopia	1.4	2.0	2.5	-1.6	-1.5	-0.7	-1.5	1.6
Vascular/heart problems diagnosed by doctor	1.1	3.1	4.1	1.9	1.8	1.4	1.7	-2.0
Cholesterol lowering medication	3.1	4.6	9.2	-2.1	-2.1	-0.9	-2.0	3.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.5	1.3	0.4	0.3	0.8	0.8	1.1
Pain experienced in last month	0.2	0.3	0.5	-0.6	-0.7	-0.2	-0.7	0.0
Supplements: Calcium	0.8	0.9	2.4	0.9	0.8	1.5	0.8	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	-0.6	-0.3	-1.3	-0.6	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	-0.7	-0.7	-0.6	-1.1	1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	-0.4	-0.5	-0.9	-0.5	0.4
Heart disease (siblings)	0.9	1.1	1.9	1.3	1.1	0.9	1.4	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.5	0.2	0.1	-0.2	0.7	-0.2
Pack years of smoking	0.2	0.4	0.7	-0.7	-0.6	-0.8	-0.3	0.4
Impedance of whole body	0.1	0.7	1.4	-0.4	-0.6	1.2	0.3	1.2
Leg fat mass (left)	2.4	9.3	10.2	-3.0	-3.2	-2.7	-3.2	3.0
Arm predicted mass (left)	1.1	5.4	8.2	-2.2	-2.2	-1.8	-2.9	2.3