[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr17:17,017,584-18,923,818

Best TWAS P=3.47e-14 · Best GWAS P=1.89e-12 conditioned to 0.249

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Brain Caudate basal ganglia	ALKBH5	0.12	0.00	lasso	6	0.03	4.4e-02	6.2	-7.6	3.5e-14	0.80	0.03	0.86	TRUE
74	ROSMAP	Brain Pre-frontal Cortex	CCDC144B	0.28	0.13	enet	17	0.17	1.5e-21	-6.7	-7.1	1.7e-12	0.50	0.04	0.96	TRUE
56	GTEx	Nerve Tibial	TOM1L2	0.11	0.04	enet	43	0.10	1.5e-07	5.0	-6.5	6.4e-11	0.33	0.97	0.01	TRUE
31	GTEx	Colon Sigmoid	RP11-258F1.1	0.09	0.01	lasso	13	0.00	2.1e-01	-6.9	-7.5	8.0e-14	0.96	0.02	0.75	FALSE
67	GTEx	Testis	ALKBH5	0.18	0.06	enet	14	0.11	1.3e-05	5.3	-7.5	8.9e-14	0.67	0.05	0.92	FALSE
32	GTEx	Colon Transverse	ALKBH5	0.16	0.08	lasso	4	0.07	3.4e-04	-6.9	-7.4	1.3e-13	0.96	0.01	0.96	FALSE
73	METSIM	Adipose	ALKBH5	0.08	0.05	blup	285	0.04	3.0e-07	-6.8	-7.4	1.6e-13	0.84	0.01	0.99	FALSE
28	GTEx	Cells Transformed fibroblasts	CCDC144B	0.06	0.02	enet	10	0.06	2.9e-05	-5.5	-7.3	2.0e-13	0.70	0.02	0.96	FALSE
13	GTEx	Artery Aorta	RP11-258F1.1	0.11	0.12	lasso	5	0.10	4.7e-06	-6.8	-7.3	2.7e-13	0.97	0.01	0.99	FALSE
79	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ALKBH5	0.07	0.05	blup	63	0.05	2.1e-03	-6.0	-7.2	4.5e-13	0.97	0.01	0.79	FALSE
5	GTEx	Adipose Subcutaneous	RP11-258F1.1	0.19	0.13	lasso	4	0.12	3.6e-10	-6.9	-7.1	1.5e-12	0.97	0.01	0.99	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	ALKBH5	0.09	0.06	lasso	2	0.06	2.9e-06	-6.9	-7.1	1.6e-12	0.99	0.01	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-258F1.1	0.08	0.02	lasso	2	0.03	1.3e-02	-7.0	-7.0	1.9e-12	1.00	0.01	0.96	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	RP11-258F1.1	0.34	0.12	lasso	1	0.10	1.6e-04	-7.0	-7.0	1.9e-12	1.00	0.01	0.98	FALSE
66	GTEx	Stomach	RP11-258F1.1	0.13	0.12	lasso	1	0.10	2.4e-05	-7.0	-7.0	1.9e-12	1.00	0.01	0.99	FALSE
47	GTEx	Lung	ALKBH5	0.07	0.01	lasso	4	0.01	5.9e-02	-7.0	-7.0	2.2e-12	0.89	0.01	0.92	FALSE
45	GTEx	Heart Left Ventricle	RP11-258F1.1	0.09	0.06	lasso	2	0.04	2.4e-03	-7.0	-7.0	2.6e-12	1.00	0.01	0.98	FALSE
55	GTEx	Nerve Tibial	ALKBH5	0.27	0.19	lasso	3	0.16	1.1e-11	-7.0	-7.0	2.6e-12	1.00	0.00	1.00	FALSE
54	GTEx	Muscle Skeletal	RP11-258F1.1	0.09	0.10	lasso	2	0.09	2.2e-09	-7.0	-7.0	2.7e-12	1.00	0.00	1.00	FALSE
63	GTEx	Skin Sun Exposed Lower leg	RP11-258F1.1	0.12	0.10	lasso	5	0.09	9.9e-08	-6.9	-7.0	3.0e-12	0.99	0.01	0.99	FALSE
16	GTEx	Artery Tibial	ALKBH5	0.17	0.16	lasso	5	0.15	4.8e-12	-6.8	-7.0	3.4e-12	0.98	0.01	0.99	FALSE
23	GTEx	Breast Mammary Tissue	ALKBH5	0.07	0.09	enet	6	0.08	6.1e-05	-6.9	-7.0	3.5e-12	0.96	0.01	0.97	FALSE
52	GTEx	Muscle Skeletal	ALKBH5	0.10	0.09	lasso	3	0.07	2.0e-07	-6.9	-7.0	3.5e-12	0.98	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALKBH5	0.02	0.02	enet	4	0.02	3.9e-03	-6.9	-6.9	3.8e-12	1.00	0.01	0.90	FALSE
43	GTEx	Esophagus Muscularis	RP11-258F1.1	0.19	0.17	lasso	6	0.13	3.1e-08	-6.8	-6.9	4.1e-12	0.99	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ALKBH5	0.05	0.05	lasso	3	0.04	1.7e-05	-7.0	-6.9	4.2e-12	0.99	0.01	0.99	FALSE
59	GTEx	Skin Sun Exposed Lower leg	ALKBH5	0.16	0.14	lasso	3	0.13	1.0e-10	-6.9	-6.9	4.6e-12	0.99	0.01	0.99	FALSE
36	GTEx	Esophagus Mucosa	DRG2	0.06	0.00	enet	19	0.01	1.3e-01	4.8	-6.9	4.7e-12	0.59	0.12	0.09	FALSE
8	GTEx	Artery Aorta	ALKBH5	0.08	0.05	lasso	7	0.06	5.2e-04	-6.7	-6.9	5.0e-12	0.83	0.02	0.95	FALSE
39	GTEx	Esophagus Mucosa	RP11-258F1.1	0.12	0.11	lasso	3	0.10	2.5e-07	-6.8	-6.9	5.4e-12	0.98	0.01	0.99	FALSE
58	GTEx	Nerve Tibial	RP11-258F1.1	0.16	0.15	lasso	1	0.15	7.5e-11	-6.9	-6.9	6.9e-12	0.99	0.01	0.99	FALSE
35	GTEx	Esophagus Mucosa	ALKBH5	0.09	0.08	lasso	8	0.06	9.3e-05	-6.8	-6.9	7.0e-12	0.95	0.01	0.97	FALSE
40	GTEx	Esophagus Muscularis	ALKBH5	0.12	0.16	lasso	2	0.14	7.3e-09	-6.8	-6.8	7.2e-12	0.99	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	ALKBH5	0.19	0.18	lasso	2	0.17	1.0e-13	-6.9	-6.8	9.7e-12	0.99	0.01	0.99	FALSE
21	GTEx	Artery Tibial	RP11-258F1.1	0.18	0.15	lasso	3	0.15	1.6e-11	-6.9	-6.8	1.3e-11	0.98	0.01	0.99	FALSE
25	GTEx	Breast Mammary Tissue (Female)	ALKBH5	0.12	0.08	lasso	3	0.08	2.3e-03	-6.8	-6.7	1.6e-11	0.99	0.01	0.93	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	SHMT1	0.08	0.03	lasso	3	0.02	1.9e-03	-6.7	-6.7	3.0e-11	0.62	0.00	0.96	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LLGL1	0.08	0.03	blup	52	0.05	1.9e-06	-6.1	-6.6	5.4e-11	0.91	0.01	0.99	FALSE
15	GTEx	Artery Coronary	TOP3A	0.27	0.19	lasso	6	0.16	6.8e-06	-5.7	6.5	7.4e-11	-0.75	0.16	0.80	FALSE
80	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LLGL1	0.23	0.09	blup	52	0.09	3.0e-05	-5.9	-6.5	7.6e-11	0.72	0.06	0.62	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ALKBH5	0.02	0.02	blup	63	0.01	3.4e-02	-6.9	-6.5	9.2e-11	0.98	0.01	0.94	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	LLGL1	0.10	0.04	lasso	7	0.04	7.5e-05	-5.9	-6.5	9.2e-11	0.88	0.02	0.98	FALSE
82	The Cancer Genome Atlas	Colon Adenocarcinoma	ALKBH5	0.14	0.07	lasso	4	0.09	5.5e-06	-6.9	-6.5	9.5e-11	0.97	0.01	0.99	FALSE
30	GTEx	Cells Transformed fibroblasts	RP11-258F1.1	0.18	0.12	lasso	3	0.15	1.7e-11	-6.8	-6.5	9.9e-11	0.91	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	LLGL1	0.09	0.01	blup	52	0.02	1.1e-05	-5.9	-6.5	1.0e-10	0.79	0.01	0.98	FALSE
70	GTEx	Thyroid	SHMT1	0.14	0.14	lasso	3	0.15	1.4e-11	-6.7	-6.4	1.3e-10	0.64	0.07	0.93	FALSE
37	GTEx	Esophagus Mucosa	LLGL1	0.38	0.39	lasso	6	0.39	8.0e-28	-6.1	-6.4	1.4e-10	0.90	0.42	0.58	FALSE
14	GTEx	Artery Coronary	CCDC144B	0.14	0.02	lasso	5	0.02	5.2e-02	5.7	-6.4	2.0e-10	0.80	0.06	0.43	FALSE
68	GTEx	Testis	RP11-258F1.1	0.17	0.10	lasso	3	0.10	2.9e-05	-6.9	-6.3	2.7e-10	0.96	0.01	0.99	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	SHMT1	0.05	0.03	lasso	5	0.03	1.1e-03	-5.8	-6.3	3.8e-10	0.68	0.01	0.95	FALSE
95	The Cancer Genome Atlas	Stomach Adenocarcinoma	ALKBH5	0.07	0.05	blup	63	0.06	2.0e-05	-6.9	-6.2	4.9e-10	0.95	0.01	0.98	FALSE
46	GTEx	Liver	RP1-178F10.3	0.18	0.17	enet	9	0.18	9.9e-06	-5.8	-6.2	5.0e-10	0.74	0.18	0.70	FALSE
48	GTEx	Lung	TOM1L2	0.07	0.02	lasso	6	0.03	1.4e-03	5.0	-6.2	6.7e-10	0.42	0.86	0.01	FALSE
69	GTEx	Thyroid	CCDC144B	0.11	0.07	enet	28	0.07	2.9e-06	-6.2	-6.1	9.6e-10	0.41	0.11	0.87	FALSE
50	GTEx	Lung	TOP3A	0.12	0.10	lasso	7	0.10	5.3e-08	-6.2	6.1	1.0e-09	-0.74	0.45	0.55	FALSE
27	GTEx	Cells Transformed fibroblasts	ALKBH5	0.16	0.05	lasso	7	0.10	9.2e-08	-6.8	-6.1	1.1e-09	0.85	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALKBH5	0.05	0.04	lasso	1	0.03	9.1e-05	-6.1	-6.1	1.1e-09	0.89	0.02	0.97	FALSE
62	GTEx	Skin Sun Exposed Lower leg	MIEF2	0.13	0.03	lasso	4	0.05	4.0e-05	-5.9	-6.1	1.3e-09	0.66	0.31	0.53	FALSE
38	GTEx	Esophagus Mucosa	MIEF2	0.11	0.07	lasso	10	0.06	1.0e-04	-6.0	-6.0	2.6e-09	0.83	0.02	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ALKBH5	0.16	0.12	lasso	3	0.12	2.7e-14	5.3	6.0	2.7e-09	-0.56	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	SHMT1	0.08	0.06	enet	9	0.06	1.6e-04	-6.7	-5.9	3.0e-09	0.66	0.01	0.99	FALSE
20	GTEx	Artery Tibial	TOP3A	0.09	0.04	lasso	5	0.04	4.4e-04	-6.2	5.9	3.1e-09	-0.67	0.42	0.48	FALSE
51	GTEx	Lung	RP11-258F1.1	0.05	0.00	lasso	5	0.00	4.1e-01	4.7	-5.9	3.3e-09	0.63	0.10	0.56	FALSE
42	GTEx	Esophagus Muscularis	TOP3A	0.07	0.00	lasso	4	0.00	3.0e-01	-6.0	5.9	3.4e-09	-0.82	0.03	0.68	FALSE
49	GTEx	Lung	SHMT1	0.15	0.13	lasso	6	0.16	2.4e-12	-4.6	-5.9	4.2e-09	0.69	0.16	0.84	FALSE
96	The Cancer Genome Atlas	Stomach Adenocarcinoma	LLGL1	0.09	0.06	enet	6	0.05	2.5e-04	-5.9	-5.9	4.2e-09	0.77	0.14	0.51	FALSE
24	GTEx	Breast Mammary Tissue (Male)	CCDC144B	0.07	0.01	lasso	3	0.02	9.9e-02	-5.8	-5.8	5.8e-09	0.69	0.03	0.13	FALSE
33	GTEx	Colon Transverse	TOP3A	0.11	0.04	lasso	5	0.07	3.5e-04	-6.8	5.8	7.3e-09	-0.91	0.01	0.97	FALSE
26	GTEx	Breast Mammary Tissue (Female)	DRG2	0.05	0.00	enet	8	-0.01	9.7e-01	5.1	-5.8	7.5e-09	0.52	0.05	0.06	FALSE
98	The Cancer Genome Atlas	Stomach Adenocarcinoma	SREBF1	0.04	0.03	blup	32	0.02	7.8e-03	6.2	5.8	9.1e-09	-0.47	0.01	0.90	FALSE
81	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SHMT1	0.11	0.05	lasso	3	0.04	4.0e-03	-6.7	-5.7	1.2e-08	0.59	0.00	0.87	FALSE
65	GTEx	Stomach	TOP3A	0.12	0.01	lasso	9	0.01	8.9e-02	5.7	5.7	1.4e-08	-0.68	0.06	0.22	FALSE
75	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ALKBH5	0.05	0.02	lasso	2	0.03	3.1e-03	-6.9	-5.7	1.6e-08	0.90	0.01	0.81	FALSE
61	GTEx	Skin Sun Exposed Lower leg	TOP3A	0.09	0.05	lasso	4	0.05	6.7e-05	-4.6	5.6	1.7e-08	-0.62	0.10	0.65	FALSE
11	GTEx	Artery Aorta	MIEF2	0.14	0.04	lasso	6	0.07	6.7e-05	-5.9	-5.6	1.8e-08	0.68	0.12	0.50	FALSE
97	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMCR7	0.06	0.02	enet	7	0.04	9.1e-04	-6.2	-5.6	1.8e-08	0.70	0.02	0.42	FALSE
17	GTEx	Artery Tibial	CCDC144B	0.11	0.07	lasso	7	0.07	6.2e-06	-6.2	-5.6	2.2e-08	0.56	0.08	0.85	FALSE
83	The Cancer Genome Atlas	Colon Adenocarcinoma	LLGL1	0.14	0.13	enet	8	0.14	3.2e-08	-6.0	-5.6	2.4e-08	0.88	0.06	0.93	FALSE
7	GTEx	Adrenal Gland	SHMT1	0.57	0.25	enet	25	0.33	9.9e-13	-4.6	-5.5	3.3e-08	0.69	0.14	0.86	FALSE
57	GTEx	Nerve Tibial	SHMT1	0.30	0.20	lasso	6	0.29	5.5e-21	-6.7	-5.5	3.5e-08	0.63	0.05	0.95	FALSE
18	GTEx	Artery Tibial	TOM1L2	0.06	0.02	enet	15	0.04	3.8e-04	4.3	-5.5	4.3e-08	0.33	0.84	0.04	FALSE
4	GTEx	Adipose Subcutaneous	TOP3A	0.12	0.03	lasso	3	0.03	1.1e-03	-4.6	5.5	4.6e-08	-0.70	0.25	0.41	FALSE
72	GTEx	Whole Blood	CCDC144B	0.05	0.06	lasso	2	0.06	3.2e-06	-6.2	-5.5	4.7e-08	0.58	0.16	0.66	FALSE
76	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LLGL1	0.07	0.04	blup	53	0.03	6.6e-04	-5.9	-5.5	4.8e-08	0.84	0.03	0.75	FALSE
10	GTEx	Artery Aorta	TOP3A	0.13	0.11	enet	8	0.15	1.8e-08	-5.9	5.3	9.5e-08	-0.72	0.44	0.55	FALSE
44	GTEx	Heart Atrial Appendage	AC122129.1	0.15	0.02	enet	9	0.08	1.4e-04	3.0	-5.3	1.0e-07	0.64	0.22	0.28	FALSE
29	GTEx	Cells Transformed fibroblasts	SHMT1	0.42	0.27	lasso	7	0.39	2.7e-31	-6.7	-5.3	1.2e-07	0.56	0.05	0.95	FALSE
100	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EVPLL	0.10	0.03	blup	16	0.05	1.0e-02	3.9	-5.3	1.2e-07	0.53	0.00	0.39	FALSE
92	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYO15A	0.09	0.03	blup	79	0.03	1.5e-02	5.3	5.3	1.3e-07	-0.45	0.09	0.13	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SMCR8	0.09	0.05	lasso	5	0.06	5.0e-08	3.9	-5.3	1.4e-07	0.58	0.61	0.38	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMCR7	0.07	0.02	lasso	3	0.01	8.3e-03	-5.9	-5.3	1.4e-07	0.76	0.04	0.20	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOM1L2	0.01	0.01	blup	83	0.01	1.8e-03	4.7	-5.2	1.5e-07	0.42	0.20	0.36	FALSE
99	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ALKBH5	0.11	0.03	blup	64	0.04	1.8e-02	-6.0	-5.2	1.5e-07	0.87	0.02	0.39	FALSE
64	GTEx	Stomach	SHMT1	0.21	0.05	enet	18	0.08	1.4e-04	-6.7	-5.2	1.6e-07	0.63	0.12	0.86	FALSE
60	GTEx	Skin Sun Exposed Lower leg	DRG2	0.06	0.07	lasso	4	0.08	6.5e-07	5.0	-5.2	1.7e-07	0.51	0.92	0.02	FALSE
71	GTEx	Whole Blood	SREBF1	0.04	0.06	lasso	5	0.05	2.4e-05	5.1	-5.2	1.9e-07	0.47	0.97	0.01	FALSE
19	GTEx	Artery Tibial	SHMT1	0.49	0.29	lasso	6	0.44	4.0e-38	-6.7	-5.2	2.0e-07	0.51	0.07	0.93	FALSE
41	GTEx	Esophagus Muscularis	SHMT1	0.28	0.21	lasso	5	0.34	2.3e-21	2.6	-5.2	2.4e-07	0.51	0.22	0.78	FALSE
53	GTEx	Muscle Skeletal	AC122129.1	0.13	0.14	lasso	4	0.13	7.3e-13	5.1	-5.2	2.5e-07	0.42	1.00	0.00	FALSE
9	GTEx	Artery Aorta	SHMT1	0.35	0.20	enet	23	0.31	1.3e-17	-6.7	-5.1	2.7e-07	0.55	0.08	0.92	FALSE
89	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SHMT1	0.05	0.02	enet	6	0.02	1.7e-02	-6.7	-5.1	2.8e-07	0.57	0.00	0.71	FALSE
12	GTEx	Artery Aorta	AC122129.1	0.06	0.01	lasso	5	0.00	3.6e-01	5.0	-5.1	3.0e-07	0.40	0.26	0.04	FALSE