[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr17:26,706,946-31,275,580

Best TWAS P=1.54e-52 · Best GWAS P=4.65e-53 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	GTEx	Nerve Tibial	SSH2	0.05	0.06	lasso	10	0.06	7.8e-05	-15.24	-15.3	1.5e-52	0.99	0.06	0.94	TRUE
4	CommonMind	Brain Pre-frontal Cortex	LRRC37B	0.09	0.08	lasso	6	0.09	1.7e-11	5.41	5.7	1.2e-08	0.04	0.03	0.97	TRUE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	EFCAB5	0.06	0.09	lasso	1	0.09	2.9e-10	-15.21	-15.2	2.9e-52	0.99	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SSH2	0.03	0.02	blup	112	0.03	2.4e-04	-15.14	-15.0	3.5e-51	0.98	0.04	0.95	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	SSH2	0.01	0.01	blup	111	0.01	1.0e-03	14.24	-14.8	7.4e-50	0.98	0.06	0.91	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	EFCAB5	0.11	0.18	enet	13	0.20	5.8e-19	-14.09	-14.8	9.4e-50	0.95	0.07	0.93	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	SSH2	0.06	0.03	blup	112	0.05	2.5e-06	13.27	-14.7	8.1e-49	0.95	0.04	0.96	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFCAB5	0.02	0.04	lasso	4	0.04	1.9e-08	-14.09	-14.7	1.1e-48	0.95	0.03	0.97	FALSE
26	GTEx	Lung	SSH2	0.08	0.05	lasso	6	0.06	2.7e-05	-14.52	-14.6	3.1e-48	0.88	0.42	0.58	FALSE
50	METSIM	Adipose	SSH2	0.03	0.03	blup	422	0.02	1.5e-04	14.25	-14.5	8.1e-48	0.92	0.06	0.94	FALSE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFCAB5	0.04	0.04	lasso	4	0.05	5.9e-06	-14.41	-14.4	6.9e-47	0.90	0.76	0.24	FALSE
39	GTEx	Thyroid	GIT1	0.06	0.08	lasso	5	0.09	3.7e-07	13.52	-14.2	6.3e-46	0.88	0.07	0.93	FALSE
84	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFCAB5	0.08	0.01	blup	79	0.03	1.7e-02	-14.48	-14.2	1.5e-45	0.92	0.03	0.69	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFCAB5	0.09	0.12	lasso	5	0.12	3.1e-13	-14.44	-14.2	1.6e-45	0.91	0.91	0.09	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	EFCAB5	0.06	0.05	blup	79	0.03	5.7e-03	-14.09	-14.1	6.4e-45	0.91	0.02	0.96	FALSE
89	The Cancer Genome Atlas	Soft Tissue Sarcoma	EFCAB5	0.06	0.07	lasso	2	0.05	8.2e-04	-14.09	-14.0	2.1e-44	0.91	0.06	0.92	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	SSH2	0.25	0.18	lasso	5	0.17	4.8e-16	13.27	-13.8	3.7e-43	0.84	0.82	0.18	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	CORO6	0.11	0.10	lasso	2	0.05	2.2e-02	-13.87	13.7	1.1e-42	-0.87	0.11	0.56	FALSE
43	GTEx	Thyroid	CORO6	0.23	0.36	lasso	5	0.37	1.2e-29	13.27	-13.6	2.5e-42	0.82	0.94	0.06	FALSE
47	METSIM	Adipose	BLMH	0.03	0.03	blup	304	0.03	6.0e-05	8.81	-13.6	4.4e-42	0.79	0.60	0.33	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EFCAB5	0.11	0.18	blup	392	0.17	1.7e-20	-14.09	-13.6	6.0e-42	0.87	0.85	0.15	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EFCAB5	0.06	0.08	lasso	2	0.07	1.4e-06	-12.80	-13.4	1.0e-40	0.83	0.17	0.82	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	CORO6	0.28	0.40	lasso	3	0.39	6.2e-40	13.27	-13.4	1.0e-40	0.81	1.00	0.00	FALSE
48	METSIM	Adipose	CORO6	0.02	0.02	bslmm	314	0.01	1.7e-02	-11.81	13.3	1.2e-40	-0.87	0.14	0.63	FALSE
41	GTEx	Thyroid	SSH2	0.12	0.17	enet	10	0.18	2.0e-13	13.27	-13.2	1.1e-39	0.83	0.67	0.33	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	EFCAB5	0.06	0.02	blup	80	0.02	1.1e-02	-14.61	-13.2	1.4e-39	0.72	0.04	0.33	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	ANKRD13B	0.14	0.20	lasso	4	0.19	2.2e-18	13.27	-13.1	1.8e-39	0.81	0.15	0.85	FALSE
32	GTEx	Skin Sun Exposed Lower leg	RP11-68I3.4	0.03	0.00	lasso	3	0.00	4.5e-01	13.23	-13.1	3.8e-39	0.74	0.04	0.50	FALSE
24	GTEx	Esophagus Muscularis	SSH2	0.04	0.01	enet	10	0.00	3.3e-01	-15.22	-13.1	4.9e-39	0.85	0.06	0.89	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFCAB5	0.07	0.09	enet	16	0.08	4.0e-09	-13.42	-13.0	9.1e-39	0.87	0.95	0.05	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	GIT1	0.06	0.05	blup	47	0.05	5.2e-06	13.52	-12.8	1.8e-37	0.74	0.00	1.00	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	SLC6A4	0.02	0.03	lasso	3	0.03	2.8e-04	-13.52	12.8	2.2e-37	-0.69	0.05	0.38	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC55	0.15	0.01	blup	64	0.04	1.9e-03	-13.50	12.5	4.7e-36	-0.77	0.03	0.35	FALSE
36	GTEx	Testis	SSH2	0.06	-0.01	enet	12	-0.01	8.6e-01	-14.09	-12.5	5.0e-36	0.81	0.10	0.44	FALSE
33	GTEx	Spleen	GIT1	0.15	0.06	lasso	5	0.06	1.4e-02	13.23	12.5	8.3e-36	-0.76	0.08	0.64	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EFCAB5	0.05	0.02	enet	22	0.02	1.7e-02	-13.54	-12.2	2.5e-34	0.81	0.05	0.65	FALSE
21	GTEx	Cells Transformed fibroblasts	CPD	0.04	0.00	lasso	3	0.03	4.4e-03	-10.40	-12.2	4.6e-34	0.59	0.16	0.19	FALSE
46	METSIM	Adipose	ANKRD13B	0.04	0.03	lasso	3	0.05	1.4e-07	-15.19	12.2	5.7e-34	-0.85	0.06	0.94	FALSE
52	NTR	Blood	SSH2	0.04	0.04	enet	22	0.05	1.7e-14	14.25	-12.0	3.2e-33	0.84	0.06	0.94	FALSE
10	GTEx	Artery Tibial	BLMH	0.12	0.04	enet	16	0.08	6.7e-07	7.45	-12.0	3.9e-33	0.73	0.51	0.49	FALSE
31	GTEx	Skin Sun Exposed Lower leg	ANKRD13B	0.08	0.04	lasso	5	0.06	1.4e-05	12.06	11.9	9.9e-33	-0.71	0.14	0.82	FALSE
55	YFS	Blood	GIT1	0.11	0.08	lasso	8	0.09	8.7e-27	-9.58	11.7	1.3e-31	-0.77	0.96	0.04	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	EFCAB5	0.04	0.03	enet	10	0.02	6.0e-03	-13.52	-11.6	2.8e-31	0.75	0.30	0.46	FALSE
66	The Cancer Genome Atlas	Esophageal Carcinoma	CCDC55	0.27	0.00	blup	64	0.00	3.5e-01	2.25	11.6	3.0e-31	-0.65	0.01	0.28	FALSE
44	GTEx	Thyroid	ANKRD13B	0.23	0.12	lasso	6	0.18	2.3e-13	-11.81	-11.1	8.7e-29	0.68	0.16	0.84	FALSE
78	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CPD	0.05	0.04	blup	65	0.02	3.4e-02	10.54	-11.0	2.5e-28	0.53	0.03	0.76	FALSE
56	YFS	Blood	SSH2	0.09	0.07	lasso	7	0.10	1.6e-30	3.96	-11.0	5.9e-28	0.78	0.59	0.41	FALSE
35	GTEx	Testis	CPD	0.16	0.17	enet	22	0.15	4.7e-07	-10.65	-10.9	1.5e-27	0.56	0.99	0.01	FALSE
49	METSIM	Adipose	GOSR1	0.13	0.20	enet	24	0.21	2.3e-31	-10.65	10.8	2.8e-27	-0.54	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	GOSR1	0.02	0.00	blup	56	0.01	4.8e-02	10.38	10.7	6.2e-27	-0.50	0.04	0.38	FALSE
15	GTEx	Brain Cortex	GOSR1	0.20	0.20	enet	7	0.18	1.4e-05	10.53	10.7	1.5e-26	-0.51	0.76	0.10	FALSE
9	GTEx	Artery Aorta	GOSR1	0.08	0.03	lasso	1	0.04	3.1e-03	-10.60	10.6	3.1e-26	-0.55	0.43	0.14	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	GOSR1	0.07	0.08	lasso	3	0.07	2.1e-07	10.53	10.6	4.9e-26	-0.49	0.34	0.66	FALSE
29	GTEx	Nerve Tibial	GOSR1	0.13	0.11	lasso	3	0.11	5.7e-08	10.34	10.5	7.2e-26	-0.47	0.99	0.00	FALSE
53	YFS	Blood	BLMH	0.07	0.07	lasso	10	0.08	3.1e-26	9.84	-10.5	7.8e-26	0.54	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GOSR1	0.06	0.11	enet	7	0.10	6.8e-12	10.38	10.3	5.5e-25	-0.47	0.52	0.48	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BLMH	0.02	0.02	blup	55	0.02	8.2e-04	6.81	-10.2	1.2e-24	0.53	0.21	0.38	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	BLMH	0.05	0.03	blup	55	0.05	1.1e-05	9.12	-10.1	4.5e-24	0.56	0.37	0.62	FALSE
74	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BLMH	0.08	0.08	lasso	6	0.06	2.3e-04	9.06	-10.0	1.0e-23	0.50	0.44	0.35	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EFCAB5	0.10	0.05	enet	24	0.04	2.0e-05	-14.09	-10.0	1.3e-23	0.65	0.12	0.88	FALSE
6	CommonMind	Brain Pre-frontal Cortex	TAOK1	0.06	0.00	bslmm	370	0.02	2.1e-03	12.06	9.7	3.6e-22	-0.61	0.11	0.43	FALSE
40	GTEx	Thyroid	GOSR1	0.05	0.04	lasso	6	0.06	4.0e-05	-10.66	9.7	4.2e-22	-0.51	0.50	0.40	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	CORO6	0.03	0.01	enet	10	0.01	1.7e-03	-9.88	9.4	3.6e-21	-0.58	0.12	0.43	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	BLMH	0.02	0.03	lasso	3	0.02	2.9e-03	8.63	-9.3	1.0e-20	0.44	0.08	0.59	FALSE
25	GTEx	Heart Left Ventricle	ANKRD13B	0.13	0.04	lasso	5	0.03	1.5e-02	5.73	9.3	1.7e-20	-0.42	0.56	0.28	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	CPD	0.04	0.01	blup	64	0.01	2.6e-03	-10.65	-9.0	1.8e-19	0.48	0.02	0.96	FALSE
27	GTEx	Lung	ANKRD13B	0.13	0.09	lasso	6	0.08	6.8e-07	5.69	9.0	2.1e-19	-0.66	0.36	0.63	FALSE
42	GTEx	Thyroid	TP53I13	0.14	0.16	enet	7	0.14	6.0e-11	4.30	-8.6	7.7e-18	0.62	0.99	0.01	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	TP53I13	0.09	0.08	enet	10	0.10	6.4e-10	5.69	-8.5	2.3e-17	0.60	0.62	0.38	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GIT1	0.09	0.01	lasso	4	0.01	1.6e-02	3.22	8.5	2.7e-17	-0.57	0.01	0.29	FALSE
3	CommonMind	Brain Pre-frontal Cortex	GOSR1	0.16	0.14	blup	315	0.14	1.2e-16	10.53	8.5	2.8e-17	-0.34	1.00	0.00	FALSE
14	GTEx	Brain Cerebellum	SUZ12P	0.11	0.01	lasso	4	0.01	1.3e-01	4.13	-8.3	1.2e-16	0.48	0.11	0.18	FALSE
34	GTEx	Testis	GIT1	0.12	0.17	lasso	2	0.13	2.1e-06	-9.81	8.1	4.8e-16	-0.49	0.54	0.39	FALSE
20	GTEx	Cells Transformed fibroblasts	BLMH	0.07	0.04	lasso	2	0.04	2.8e-04	7.45	-7.9	2.2e-15	0.39	0.74	0.01	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	CPD	0.11	0.01	lasso	2	0.01	3.7e-02	7.85	-7.8	4.2e-15	0.30	0.01	0.30	FALSE
11	GTEx	Artery Tibial	GOSR1	0.09	0.08	enet	15	0.05	6.9e-05	10.34	7.7	1.2e-14	-0.34	0.92	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CPD	0.03	0.01	enet	11	0.02	4.3e-03	10.34	-7.2	6.7e-13	0.37	0.30	0.14	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	ABHD15	0.04	0.03	lasso	2	0.02	1.4e-05	4.30	6.4	2.0e-10	-0.49	0.17	0.64	FALSE
54	YFS	Blood	CPD	0.18	0.13	enet	38	0.14	8.5e-42	7.07	-6.2	4.9e-10	0.25	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	SH3GL1P2	0.43	0.09	enet	25	0.19	8.2e-23	-4.22	6.2	5.1e-10	-0.31	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOSR1	0.15	0.00	blup	56	0.04	1.1e-03	-10.40	6.2	5.4e-10	-0.23	0.03	0.26	FALSE
45	METSIM	Adipose	ABHD15	0.07	0.06	lasso	3	0.06	6.1e-09	2.49	6.0	1.9e-09	-0.44	0.98	0.02	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	ABHD15	0.06	0.03	blup	44	0.03	1.1e-03	8.08	-5.9	3.7e-09	0.29	0.01	0.59	FALSE
38	GTEx	Testis	RP11-68I3.4	0.10	0.02	lasso	4	0.03	1.4e-02	2.43	-5.8	4.8e-09	0.44	0.11	0.58	FALSE
88	The Cancer Genome Atlas	Rectum Adenocarcinoma	TP53I13	0.22	0.09	lasso	1	0.04	4.4e-02	5.69	-5.7	1.3e-08	0.48	0.02	0.22	FALSE
23	GTEx	Esophagus Mucosa	RHOT1	0.07	0.00	lasso	14	0.00	1.5e-01	5.26	-5.6	2.6e-08	-0.05	0.03	0.53	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	BLMH	0.03	0.01	enet	8	0.02	1.9e-04	8.77	-5.5	3.7e-08	0.29	0.09	0.05	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RHOT1	0.10	0.01	lasso	13	0.01	1.1e-01	5.47	-5.5	4.2e-08	-0.04	0.03	0.77	FALSE
18	GTEx	Breast Mammary Tissue	CTC-542B22.2	0.07	0.01	enet	8	0.03	1.7e-02	5.17	5.5	4.8e-08	0.06	0.05	0.85	FALSE
51	NTR	Blood	MYO18A	0.01	0.00	blup	340	0.00	2.8e-02	1.29	-5.5	5.1e-08	0.30	0.06	0.04	FALSE
7	CommonMind	Brain Pre-frontal Cortex	UTP6	0.08	0.08	lasso	3	0.08	4.3e-10	5.22	-5.4	5.2e-08	-0.03	0.04	0.96	FALSE
22	GTEx	Colon Transverse	RHOT1	0.12	0.00	enet	23	0.00	3.6e-01	5.47	-5.3	9.4e-08	-0.06	0.03	0.81	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	LRRC37B	0.02	0.02	blup	23	0.02	3.5e-03	5.40	5.3	1.1e-07	0.05	0.02	0.86	FALSE
16	GTEx	Brain Cortex	LRRC37B	0.14	0.06	lasso	8	0.02	9.5e-02	5.47	5.3	1.4e-07	0.05	0.03	0.80	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC37B	0.07	0.10	enet	5	0.09	1.0e-10	5.23	5.3	1.4e-07	0.04	0.02	0.98	FALSE
13	GTEx	Brain Cerebellum	ABHD15	0.26	0.01	lasso	5	0.05	1.4e-02	0.89	-5.2	1.8e-07	0.29	0.06	0.12	FALSE
12	GTEx	Artery Tibial	UTP6	0.07	0.02	lasso	3	0.02	5.9e-03	5.17	-5.2	2.2e-07	-0.05	0.03	0.94	FALSE
37	GTEx	Testis	TP53I13	0.39	0.38	lasso	9	0.38	7.3e-18	2.43	-5.2	2.2e-07	0.42	1.00	0.00	FALSE
8	GTEx	Adipose Subcutaneous	ANKRD13B	0.14	0.14	lasso	5	0.15	2.0e-12	5.69	5.1	2.7e-07	-0.44	1.00	0.00	FALSE
28	GTEx	Muscle Skeletal	BLMH	0.11	0.00	enet	31	0.03	7.7e-04	1.02	-5.1	2.8e-07	0.41	0.08	0.08	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RHOT1	0.03	0.04	enet	6	0.04	3.4e-05	4.48	-5.1	3.1e-07	-0.07	0.05	0.87	FALSE