[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr17:26,706,946-31,275,580

Best TWAS P=1.54e-52 · Best GWAS P=4.65e-53 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CPD 0.03 0.01 enet 11 0.02 4.3e-03 10.34 -7.2 6.7e-13 0.37 0.30 0.14 FALSE
2 CommonMind Brain Pre-frontal Cortex EFCAB5 0.11 0.18 blup 392 0.17 1.7e-20 -14.09 -13.6 6.0e-42 0.87 0.85 0.15 FALSE
3 CommonMind Brain Pre-frontal Cortex GOSR1 0.16 0.14 blup 315 0.14 1.2e-16 10.53 8.5 2.8e-17 -0.34 1.00 0.00 FALSE
4 CommonMind Brain Pre-frontal Cortex LRRC37B 0.09 0.08 lasso 6 0.09 1.7e-11 5.41 5.7 1.2e-08 0.04 0.03 0.97 TRUE
5 CommonMind Brain Pre-frontal Cortex SH3GL1P2 0.43 0.09 enet 25 0.19 8.2e-23 -4.22 6.2 5.1e-10 -0.31 1.00 0.00 FALSE
6 CommonMind Brain Pre-frontal Cortex TAOK1 0.06 0.00 bslmm 370 0.02 2.1e-03 12.06 9.7 3.6e-22 -0.61 0.11 0.43 FALSE
7 CommonMind Brain Pre-frontal Cortex UTP6 0.08 0.08 lasso 3 0.08 4.3e-10 5.22 -5.4 5.2e-08 -0.03 0.04 0.96 FALSE
8 GTEx Adipose Subcutaneous ANKRD13B 0.14 0.14 lasso 5 0.15 2.0e-12 5.69 5.1 2.7e-07 -0.44 1.00 0.00 FALSE
9 GTEx Artery Aorta GOSR1 0.08 0.03 lasso 1 0.04 3.1e-03 -10.60 10.6 3.1e-26 -0.55 0.43 0.14 FALSE
10 GTEx Artery Tibial BLMH 0.12 0.04 enet 16 0.08 6.7e-07 7.45 -12.0 3.9e-33 0.73 0.51 0.49 FALSE
11 GTEx Artery Tibial GOSR1 0.09 0.08 enet 15 0.05 6.9e-05 10.34 7.7 1.2e-14 -0.34 0.92 0.00 FALSE
12 GTEx Artery Tibial UTP6 0.07 0.02 lasso 3 0.02 5.9e-03 5.17 -5.2 2.2e-07 -0.05 0.03 0.94 FALSE
13 GTEx Brain Cerebellum ABHD15 0.26 0.01 lasso 5 0.05 1.4e-02 0.89 -5.2 1.8e-07 0.29 0.06 0.12 FALSE
14 GTEx Brain Cerebellum SUZ12P 0.11 0.01 lasso 4 0.01 1.3e-01 4.13 -8.3 1.2e-16 0.48 0.11 0.18 FALSE
15 GTEx Brain Cortex GOSR1 0.20 0.20 enet 7 0.18 1.4e-05 10.53 10.7 1.5e-26 -0.51 0.76 0.10 FALSE
16 GTEx Brain Cortex LRRC37B 0.14 0.06 lasso 8 0.02 9.5e-02 5.47 5.3 1.4e-07 0.05 0.03 0.80 FALSE
17 GTEx Brain Nucleus accumbens basal ganglia CORO6 0.11 0.10 lasso 2 0.05 2.2e-02 -13.87 13.7 1.1e-42 -0.87 0.11 0.56 FALSE
18 GTEx Breast Mammary Tissue CTC-542B22.2 0.07 0.01 enet 8 0.03 1.7e-02 5.17 5.5 4.8e-08 0.06 0.05 0.85 FALSE
19 GTEx Cells EBV-transformed lymphocytes RHOT1 0.10 0.01 lasso 13 0.01 1.1e-01 5.47 -5.5 4.2e-08 -0.04 0.03 0.77 FALSE
20 GTEx Cells Transformed fibroblasts BLMH 0.07 0.04 lasso 2 0.04 2.8e-04 7.45 -7.9 2.2e-15 0.39 0.74 0.01 FALSE
21 GTEx Cells Transformed fibroblasts CPD 0.04 0.00 lasso 3 0.03 4.4e-03 -10.40 -12.2 4.6e-34 0.59 0.16 0.19 FALSE
22 GTEx Colon Transverse RHOT1 0.12 0.00 enet 23 0.00 3.6e-01 5.47 -5.3 9.4e-08 -0.06 0.03 0.81 FALSE
23 GTEx Esophagus Mucosa RHOT1 0.07 0.00 lasso 14 0.00 1.5e-01 5.26 -5.6 2.6e-08 -0.05 0.03 0.53 FALSE
24 GTEx Esophagus Muscularis SSH2 0.04 0.01 enet 10 0.00 3.3e-01 -15.22 -13.1 4.9e-39 0.85 0.06 0.89 FALSE
25 GTEx Heart Left Ventricle ANKRD13B 0.13 0.04 lasso 5 0.03 1.5e-02 5.73 9.3 1.7e-20 -0.42 0.56 0.28 FALSE
26 GTEx Lung SSH2 0.08 0.05 lasso 6 0.06 2.7e-05 -14.52 -14.6 3.1e-48 0.88 0.42 0.58 FALSE
27 GTEx Lung ANKRD13B 0.13 0.09 lasso 6 0.08 6.8e-07 5.69 9.0 2.1e-19 -0.66 0.36 0.63 FALSE
28 GTEx Muscle Skeletal BLMH 0.11 0.00 enet 31 0.03 7.7e-04 1.02 -5.1 2.8e-07 0.41 0.08 0.08 FALSE
29 GTEx Nerve Tibial GOSR1 0.13 0.11 lasso 3 0.11 5.7e-08 10.34 10.5 7.2e-26 -0.47 0.99 0.00 FALSE
30 GTEx Nerve Tibial SSH2 0.05 0.06 lasso 10 0.06 7.8e-05 -15.24 -15.3 1.5e-52 0.99 0.06 0.94 TRUE
31 GTEx Skin Sun Exposed Lower leg ANKRD13B 0.08 0.04 lasso 5 0.06 1.4e-05 12.06 11.9 9.9e-33 -0.71 0.14 0.82 FALSE
32 GTEx Skin Sun Exposed Lower leg RP11-68I3.4 0.03 0.00 lasso 3 0.00 4.5e-01 13.23 -13.1 3.8e-39 0.74 0.04 0.50 FALSE
33 GTEx Spleen GIT1 0.15 0.06 lasso 5 0.06 1.4e-02 13.23 12.5 8.3e-36 -0.76 0.08 0.64 FALSE
34 GTEx Testis GIT1 0.12 0.17 lasso 2 0.13 2.1e-06 -9.81 8.1 4.8e-16 -0.49 0.54 0.39 FALSE
35 GTEx Testis CPD 0.16 0.17 enet 22 0.15 4.7e-07 -10.65 -10.9 1.5e-27 0.56 0.99 0.01 FALSE
36 GTEx Testis SSH2 0.06 -0.01 enet 12 -0.01 8.6e-01 -14.09 -12.5 5.0e-36 0.81 0.10 0.44 FALSE
37 GTEx Testis TP53I13 0.39 0.38 lasso 9 0.38 7.3e-18 2.43 -5.2 2.2e-07 0.42 1.00 0.00 FALSE
38 GTEx Testis RP11-68I3.4 0.10 0.02 lasso 4 0.03 1.4e-02 2.43 -5.8 4.8e-09 0.44 0.11 0.58 FALSE
39 GTEx Thyroid GIT1 0.06 0.08 lasso 5 0.09 3.7e-07 13.52 -14.2 6.3e-46 0.88 0.07 0.93 FALSE
40 GTEx Thyroid GOSR1 0.05 0.04 lasso 6 0.06 4.0e-05 -10.66 9.7 4.2e-22 -0.51 0.50 0.40 FALSE
41 GTEx Thyroid SSH2 0.12 0.17 enet 10 0.18 2.0e-13 13.27 -13.2 1.1e-39 0.83 0.67 0.33 FALSE
42 GTEx Thyroid TP53I13 0.14 0.16 enet 7 0.14 6.0e-11 4.30 -8.6 7.7e-18 0.62 0.99 0.01 FALSE
43 GTEx Thyroid CORO6 0.23 0.36 lasso 5 0.37 1.2e-29 13.27 -13.6 2.5e-42 0.82 0.94 0.06 FALSE
44 GTEx Thyroid ANKRD13B 0.23 0.12 lasso 6 0.18 2.3e-13 -11.81 -11.1 8.7e-29 0.68 0.16 0.84 FALSE
45 METSIM Adipose ABHD15 0.07 0.06 lasso 3 0.06 6.1e-09 2.49 6.0 1.9e-09 -0.44 0.98 0.02 FALSE
46 METSIM Adipose ANKRD13B 0.04 0.03 lasso 3 0.05 1.4e-07 -15.19 12.2 5.7e-34 -0.85 0.06 0.94 FALSE
47 METSIM Adipose BLMH 0.03 0.03 blup 304 0.03 6.0e-05 8.81 -13.6 4.4e-42 0.79 0.60 0.33 FALSE
48 METSIM Adipose CORO6 0.02 0.02 bslmm 314 0.01 1.7e-02 -11.81 13.3 1.2e-40 -0.87 0.14 0.63 FALSE
49 METSIM Adipose GOSR1 0.13 0.20 enet 24 0.21 2.3e-31 -10.65 10.8 2.8e-27 -0.54 1.00 0.00 FALSE
50 METSIM Adipose SSH2 0.03 0.03 blup 422 0.02 1.5e-04 14.25 -14.5 8.1e-48 0.92 0.06 0.94 FALSE
51 NTR Blood MYO18A 0.01 0.00 blup 340 0.00 2.8e-02 1.29 -5.5 5.1e-08 0.30 0.06 0.04 FALSE
52 NTR Blood SSH2 0.04 0.04 enet 22 0.05 1.7e-14 14.25 -12.0 3.2e-33 0.84 0.06 0.94 FALSE
53 YFS Blood BLMH 0.07 0.07 lasso 10 0.08 3.1e-26 9.84 -10.5 7.8e-26 0.54 1.00 0.00 FALSE
54 YFS Blood CPD 0.18 0.13 enet 38 0.14 8.5e-42 7.07 -6.2 4.9e-10 0.25 1.00 0.00 FALSE
55 YFS Blood GIT1 0.11 0.08 lasso 8 0.09 8.7e-27 -9.58 11.7 1.3e-31 -0.77 0.96 0.04 FALSE
56 YFS Blood SSH2 0.09 0.07 lasso 7 0.10 1.6e-30 3.96 -11.0 5.9e-28 0.78 0.59 0.41 FALSE
57 The Cancer Genome Atlas Bladder Urothelial Carcinoma EFCAB5 0.06 0.08 lasso 2 0.07 1.4e-06 -12.80 -13.4 1.0e-40 0.83 0.17 0.82 FALSE
58 The Cancer Genome Atlas Breast Invasive Carcinoma ABHD15 0.04 0.03 lasso 2 0.02 1.4e-05 4.30 6.4 2.0e-10 -0.49 0.17 0.64 FALSE
59 The Cancer Genome Atlas Breast Invasive Carcinoma BLMH 0.03 0.01 enet 8 0.02 1.9e-04 8.77 -5.5 3.7e-08 0.29 0.09 0.05 FALSE
60 The Cancer Genome Atlas Breast Invasive Carcinoma CORO6 0.03 0.01 enet 10 0.01 1.7e-03 -9.88 9.4 3.6e-21 -0.58 0.12 0.43 FALSE
61 The Cancer Genome Atlas Breast Invasive Carcinoma CPD 0.04 0.01 blup 64 0.01 2.6e-03 -10.65 -9.0 1.8e-19 0.48 0.02 0.96 FALSE
62 The Cancer Genome Atlas Breast Invasive Carcinoma EFCAB5 0.02 0.04 lasso 4 0.04 1.9e-08 -14.09 -14.7 1.1e-48 0.95 0.03 0.97 FALSE
63 The Cancer Genome Atlas Breast Invasive Carcinoma SSH2 0.01 0.01 blup 111 0.01 1.0e-03 14.24 -14.8 7.4e-50 0.98 0.06 0.91 FALSE
64 The Cancer Genome Atlas Colon Adenocarcinoma CCDC55 0.15 0.01 blup 64 0.04 1.9e-03 -13.50 12.5 4.7e-36 -0.77 0.03 0.35 FALSE
65 The Cancer Genome Atlas Colon Adenocarcinoma EFCAB5 0.06 0.05 blup 79 0.03 5.7e-03 -14.09 -14.1 6.4e-45 0.91 0.02 0.96 FALSE
66 The Cancer Genome Atlas Esophageal Carcinoma CCDC55 0.27 0.00 blup 64 0.00 3.5e-01 2.25 11.6 3.0e-31 -0.65 0.01 0.28 FALSE
67 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma EFCAB5 0.10 0.05 enet 24 0.04 2.0e-05 -14.09 -10.0 1.3e-23 0.65 0.12 0.88 FALSE
68 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GIT1 0.09 0.01 lasso 4 0.01 1.6e-02 3.22 8.5 2.7e-17 -0.57 0.01 0.29 FALSE
69 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma BLMH 0.02 0.02 blup 55 0.02 8.2e-04 6.81 -10.2 1.2e-24 0.53 0.21 0.38 FALSE
70 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EFCAB5 0.09 0.12 lasso 5 0.12 3.1e-13 -14.44 -14.2 1.6e-45 0.91 0.91 0.09 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GOSR1 0.06 0.11 enet 7 0.10 6.8e-12 10.38 10.3 5.5e-25 -0.47 0.52 0.48 FALSE
72 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RHOT1 0.03 0.04 enet 6 0.04 3.4e-05 4.48 -5.1 3.1e-07 -0.07 0.05 0.87 FALSE
73 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SSH2 0.03 0.02 blup 112 0.03 2.4e-04 -15.14 -15.0 3.5e-51 0.98 0.04 0.95 FALSE
74 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma BLMH 0.08 0.08 lasso 6 0.06 2.3e-04 9.06 -10.0 1.0e-23 0.50 0.44 0.35 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EFCAB5 0.05 0.02 enet 22 0.02 1.7e-02 -13.54 -12.2 2.5e-34 0.81 0.05 0.65 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma EFCAB5 0.07 0.09 enet 16 0.08 4.0e-09 -13.42 -13.0 9.1e-39 0.87 0.95 0.05 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma LRRC37B 0.07 0.10 enet 5 0.09 1.0e-10 5.23 5.3 1.4e-07 0.04 0.02 0.98 FALSE
78 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CPD 0.05 0.04 blup 65 0.02 3.4e-02 10.54 -11.0 2.5e-28 0.53 0.03 0.76 FALSE
79 The Cancer Genome Atlas Lung Adenocarcinoma EFCAB5 0.06 0.09 lasso 1 0.09 2.9e-10 -15.21 -15.2 2.9e-52 0.99 0.00 1.00 FALSE
80 The Cancer Genome Atlas Lung Adenocarcinoma LRRC37B 0.02 0.02 blup 23 0.02 3.5e-03 5.40 5.3 1.1e-07 0.05 0.02 0.86 FALSE
81 The Cancer Genome Atlas Lung Adenocarcinoma SSH2 0.06 0.03 blup 112 0.05 2.5e-06 13.27 -14.7 8.1e-49 0.95 0.04 0.96 FALSE
82 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EFCAB5 0.04 0.04 lasso 4 0.05 5.9e-06 -14.41 -14.4 6.9e-47 0.90 0.76 0.24 FALSE
83 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GOSR1 0.15 0.00 blup 56 0.04 1.1e-03 -10.40 6.2 5.4e-10 -0.23 0.03 0.26 FALSE
84 The Cancer Genome Atlas Pancreatic Adenocarcinoma EFCAB5 0.08 0.01 blup 79 0.03 1.7e-02 -14.48 -14.2 1.5e-45 0.92 0.03 0.69 FALSE
85 The Cancer Genome Atlas Prostate Adenocarcinoma BLMH 0.05 0.03 blup 55 0.05 1.1e-05 9.12 -10.1 4.5e-24 0.56 0.37 0.62 FALSE
86 The Cancer Genome Atlas Prostate Adenocarcinoma EFCAB5 0.04 0.03 enet 10 0.02 6.0e-03 -13.52 -11.6 2.8e-31 0.75 0.30 0.46 FALSE
87 The Cancer Genome Atlas Prostate Adenocarcinoma GOSR1 0.02 0.00 blup 56 0.01 4.8e-02 10.38 10.7 6.2e-27 -0.50 0.04 0.38 FALSE
88 The Cancer Genome Atlas Rectum Adenocarcinoma TP53I13 0.22 0.09 lasso 1 0.04 4.4e-02 5.69 -5.7 1.3e-08 0.48 0.02 0.22 FALSE
89 The Cancer Genome Atlas Soft Tissue Sarcoma EFCAB5 0.06 0.07 lasso 2 0.05 8.2e-04 -14.09 -14.0 2.1e-44 0.91 0.06 0.92 FALSE
90 The Cancer Genome Atlas Stomach Adenocarcinoma CPD 0.11 0.01 lasso 2 0.01 3.7e-02 7.85 -7.8 4.2e-15 0.30 0.01 0.30 FALSE
91 The Cancer Genome Atlas Stomach Adenocarcinoma EFCAB5 0.06 0.02 blup 80 0.02 1.1e-02 -14.61 -13.2 1.4e-39 0.72 0.04 0.33 FALSE
92 The Cancer Genome Atlas Thyroid Carcinoma ABHD15 0.06 0.03 blup 44 0.03 1.1e-03 8.08 -5.9 3.7e-09 0.29 0.01 0.59 FALSE
93 The Cancer Genome Atlas Thyroid Carcinoma ANKRD13B 0.14 0.20 lasso 4 0.19 2.2e-18 13.27 -13.1 1.8e-39 0.81 0.15 0.85 FALSE
94 The Cancer Genome Atlas Thyroid Carcinoma BLMH 0.02 0.03 lasso 3 0.02 2.9e-03 8.63 -9.3 1.0e-20 0.44 0.08 0.59 FALSE
95 The Cancer Genome Atlas Thyroid Carcinoma CORO6 0.28 0.40 lasso 3 0.39 6.2e-40 13.27 -13.4 1.0e-40 0.81 1.00 0.00 FALSE
96 The Cancer Genome Atlas Thyroid Carcinoma EFCAB5 0.11 0.18 enet 13 0.20 5.8e-19 -14.09 -14.8 9.4e-50 0.95 0.07 0.93 FALSE
97 The Cancer Genome Atlas Thyroid Carcinoma GIT1 0.06 0.05 blup 47 0.05 5.2e-06 13.52 -12.8 1.8e-37 0.74 0.00 1.00 FALSE
98 The Cancer Genome Atlas Thyroid Carcinoma GOSR1 0.07 0.08 lasso 3 0.07 2.1e-07 10.53 10.6 4.9e-26 -0.49 0.34 0.66 FALSE
99 The Cancer Genome Atlas Thyroid Carcinoma SLC6A4 0.02 0.03 lasso 3 0.03 2.8e-04 -13.52 12.8 2.2e-37 -0.69 0.05 0.38 FALSE
100 The Cancer Genome Atlas Thyroid Carcinoma SSH2 0.25 0.18 lasso 5 0.17 4.8e-16 13.27 -13.8 3.7e-43 0.84 0.82 0.18 FALSE
101 The Cancer Genome Atlas Thyroid Carcinoma TP53I13 0.09 0.08 enet 10 0.10 6.4e-10 5.69 -8.5 2.3e-17 0.60 0.62 0.38 FALSE