TWAS hub - HOXB7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0256	0.0102	3.6e-05	0.006	0.012	0.011	0.011	0.005	0.00450	5.1e-05	0.00012	0.00015	0.0051
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0290	0.0182	7.2e-03	0.030	0.019	0.026	NA	0.008	0.00021	3.1e-03	0.00060	NA	0.0350

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hand grip strength (left)	10.8	28.4	33.5	4.8	5.8
Hand grip strength (right)	8.5	23.0	23.3	4.8	4.8
Ovarian Cancer	8.3	11.0	16.1	4.0	2.4
Mouth/teeth dental problems: Dentures	5.5	9.4	18.0	4.2	0.9
Waist circumference	5.4	19.7	20.6	4.3	4.5
Lung FEV1/FVC ratio	5.1	26.1	43.7	-6.6	-2.9
Health satisfaction	4.9	6.3	11.6	3.4	1.0
Respiratory disease	4.8	10.8	13.4	3.7	2.9
Peak expiratory flow (PEF)	4.8	11.1	17.5	-4.2	-2.2
Mouth/teeth dental problems: Loose teeth	4.7	5.6	7.3	-2.7	-2.0
Medication: Ventolin 100micrograms inhaler	4.6	5.9	8.9	3.0	1.7
Wheeze or whistling in the chest in last year	4.6	8.3	11.9	3.5	2.2
Asthma (self-reported)	4.4	8.7	10.6	3.3	2.6
Asthma	4.3	8.6	10.9	3.3	2.5
Bilateral oophorectomy (both ovaries removed)	4.2	4.8	5.6	-2.4	-2.0
Rheumatoid Arthritis	3.7	5.1	5.7	-2.4	-2.1
Type 2 Diabetes (T2D) (2012)	3.7	4.2	8.5	-2.9	0.0
Blood Red Count	3.7	35.8	49.7	7.0	4.7
Comparative body size at age 10	3.6	9.9	18.7	1.0	4.3
Chronic bronchitis/emphysema (father)	3.5	4.1	4.5	-2.1	-1.9
Pulse wave Arterial Stiffness index	3.5	4.0	5.2	-1.7	-2.3
Illnesses of father: None of the above (group 1)	3.5	4.3	6.4	1.5	2.5
Number of children fathered	3.3	3.8	5.0	2.2	1.6
High cholesterol (Self-reported)	3.3	5.9	9.5	1.5	3.1
Medication: Simvastatin	3.2	4.6	8.0	1.2	2.8
Chronotype (morning person)	3.1	7.2	14.2	0.4	3.8
Maternal smoking around birth	3.1	4.4	5.9	-1.7	-2.4
Body Mass Index (BMI) (2010)	3.0	4.1	4.4	1.9	2.1
Diverticular disease/diverticulitis (self-reported)	3.0	3.5	5.9	-1.1	-2.4
Had other major operations	3.0	3.6	5.5	1.3	2.4
Pulse wave peak to peak time	2.9	3.4	3.6	1.8	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.5	4.8	1.5	2.2
Hearing difficulty/problems: Yes	2.7	4.0	4.9	1.8	2.2
Townsend deprivation index at recruitment	2.7	3.8	4.1	2.0	1.9
Body mass index (BMI)	2.7	11.4	17.3	2.4	4.2
Waist Hip Ratio (WHR)	2.6	11.5	11.8	3.3	3.4
Diabetes (father)	2.6	3.2	4.7	-1.3	-2.2
Ever had bowel cancer screening	2.6	3.1	5.5	-2.4	-0.8
Qualifications: nursing, teaching	2.6	4.1	7.6	-0.8	-2.7
Sitting height	2.5	18.0	34.7	-1.1	-5.9
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.8	3.2	-1.6	-1.8
High blood pressure (siblings)	2.5	3.6	6.0	-2.4	-1.1
Chest pain or discomfort	2.5	3.6	7.0	2.6	-0.4
Tinnitus: Yes, now most or all of the time	2.5	2.9	3.6	1.5	1.9
Basal cell carcinoma (self-reported)	2.5	3.0	4.5	2.1	1.2
Systolic Blood Pressure	2.4	12.0	20.1	-4.5	-2.0
Average weekly spirits intake	2.4	3.0	4.0	2.0	1.4
Exposure to tobacco smoke outside home	2.4	3.2	3.8	2.0	1.6
Overall health rating	2.4	5.2	8.8	3.0	1.2
Commuting to job workplace: Walk	2.4	2.6	3.2	1.4	1.8
Stomach or abdominal pain in last month	2.3	2.9	5.1	-0.9	-2.3
Chronic bronchitis/emphysema (mother)	2.3	2.7	4.5	-1.0	-2.1
Leg fat percentage (right)	2.2	7.9	12.0	2.0	3.5
Impedance of arm (right)	2.1	9.6	17.2	-1.4	-4.1
Medication: Lansoprazole	2.1	2.4	4.1	-2.0	-0.9
Back pain experienced in last month	2.1	3.0	5.8	-0.5	-2.4
Impedance of whole body	2.1	10.8	19.2	-1.6	-4.4
Age when periods started (menarche)	2.0	4.9	8.8	-1.0	-3.0
Hip circumference	2.0	8.5	11.1	3.3	2.4
Average weekly champagne plus white wine intake	2.0	2.7	5.2	-0.4	-2.3
BMI	1.9	11.0	18.2	1.9	4.3
Wears glasses or contact lenses	1.9	2.1	4.2	0.3	2.1
Cholesterol lowering medication	1.9	2.8	5.6	0.2	2.4
Alcohol drinker status: Previous	1.9	2.2	3.9	-0.7	-2.0
HbA1C	1.8	2.0	3.1	-1.8	-1.0
Medication: Cholesterol lowering	1.8	2.8	5.1	0.8	2.3
Depression (self-reported)	1.8	2.2	2.5	-1.4	-1.6
Exposure to tobacco smoke at home	1.8	2.0	3.7	-0.5	-1.9
Leg fat mass (right)	1.8	7.1	8.9	2.3	3.0
Angina	1.7	2.2	3.9	-2.0	-0.8
Allergy	1.7	4.0	7.0	-2.6	-1.0
Illnesses of siblings	1.7	2.4	4.4	2.1	0.7
Father’s age at death	1.7	2.2	3.4	-1.0	-1.9
Impedance of arm (left)	1.7	7.9	14.6	-1.1	-3.8
Eye problems/disorders: Glaucoma	1.7	2.1	3.8	1.9	0.6
Height	1.6	31.8	61.9	1.3	-7.9
Severe depression (siblings)	1.6	1.8	3.1	-0.6	-1.8
Qualifications: CSEs or equivalent	1.6	2.2	2.8	-1.2	-1.7
Angina (self-reported)	1.6	2.1	3.6	-1.9	-0.8
Long-standing illness, disability or infirmity	1.6	2.4	3.5	1.9	1.2
Prostate Cancer	1.5	2.1	4.2	-0.2	-2.0
Impedance of leg (left)	1.5	7.4	12.2	-1.6	-3.5
Diabetes (self-reported)	1.5	2.3	4.4	-2.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	3.6	1.6	-1.9
Arm fat percentage (left)	1.5	6.0	8.2	1.9	2.9
Medication: Gliclazide	1.5	1.6	2.9	-0.7	-1.7
Arm fat mass (left)	1.5	6.0	6.2	2.4	2.5
Ever taken oral contraceptive pill	1.5	1.7	2.6	-0.9	-1.6
Hearing aid user	1.5	1.7	2.9	1.7	0.7
Financial situation satisfaction	1.5	1.8	3.3	1.8	0.6
Supplements: Fish oil (including cod liver oil)	1.5	1.9	2.9	1.0	1.7
Leg fat percentage (left)	1.5	5.6	8.9	1.5	3.0
Leg fat mass (left)	1.5	5.9	7.8	2.0	2.8
Lung FVC	1.4	7.1	7.3	2.6	2.7
Sensitivity / hurt feelings	1.4	2.4	3.8	-1.9	-1.0
Financial difficulties in last 2 years	1.4	1.9	2.8	1.0	-1.7
Arm fat mass (right)	1.4	5.8	6.4	2.3	2.5
Standing height	1.4	14.1	27.5	0.9	-5.2
Pulse wave reflection index	1.4	1.7	2.5	-1.0	-1.6
Diabetes diagnosed by doctor	1.4	2.3	4.4	-2.1	-0.5
Eye problems/disorders: Cataract	1.4	1.6	1.9	1.4	1.1
Risk taking	1.4	2.0	4.1	0.0	-2.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	2.7	-0.6	-1.6
Number of incorrect matches in round	1.3	2.2	3.2	-1.1	-1.8
Arm fat percentage (right)	1.3	5.0	7.0	1.7	2.6
Pulse rate, automated reading	1.3	4.3	6.2	2.5	1.6
Family relationship satisfaction	1.3	1.6	3.2	1.8	0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.0	-1.0	-1.4
Guilty feelings	1.3	2.0	3.1	1.8	0.9
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.2	1.8	-0.1
Depressed Affect (Nagel 2018)	1.2	2.6	5.0	-0.5	-2.2
Primary Biliary Cirrhosis	1.2	1.7	2.6	1.6	0.9
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.0	-2.0	-0.6
Migraine (self-reported)	1.2	1.5	1.7	1.2	-1.3
Number of full sisters	1.2	1.5	2.6	1.6	-0.6
Illnesses of siblings: Diabetes	1.2	1.5	1.5	-1.2	-1.2
Medication: Paracetamol	1.2	1.9	3.1	0.8	-1.8
Medication: Lisinopril	1.2	1.6	2.3	-1.5	-0.9
Commuting to job workplace: Cycle	1.2	1.4	1.8	-1.0	-1.4
Crohns Disease (2017)	1.1	2.3	4.5	2.1	0.4
Major Depression (MDD)	1.1	1.3	1.6	-1.0	-1.3
Crohns Disease (2012)	1.1	1.9	2.7	1.6	1.0
Suffer from ‘nerves’	1.1	1.8	2.6	-1.0	-1.6
Depression (Nagel 2018)	1.0	1.6	3.2	0.0	-1.8
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.1	-1.3	-1.8
Blood White Count	1.0	7.4	10.2	-2.1	-3.2
Relative age of first facial hair	1.0	2.0	2.1	-1.4	-1.4
Systolic blood pressure, automated reading	1.0	2.8	5.5	-2.3	0.2
Impedance of leg (right)	1.0	4.7	8.3	-1.1	-2.9
Mouth/teeth dental problems	1.0	1.5	3.0	-1.7	-0.1
Tense / ‘highly strung’	1.0	1.7	3.4	1.8	0.2
Glaucoma (self-reported)	1.0	1.1	2.1	1.5	0.4
Eye problems/disorders: None of the above	1.0	1.1	2.1	-1.4	-0.4
Mean time to correctly identify matches	1.0	2.0	2.3	1.3	1.5
Number of self-reported non-cancer illnesses	1.0	1.7	1.7	1.3	1.3
Medication: Bendroflumethiazide	1.0	1.5	2.0	-1.4	-1.0
Medication: Atorvastatin	1.0	1.2	2.3	0.4	1.5
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.9	-1.4	-0.6
Irritable Bowel Disease (IBD)	0.9	2.3	4.4	2.1	-0.3
Reaction Time	0.9	1.7	1.8	1.2	1.3
LDL Cholesterol	0.9	1.4	2.7	1.6	0.0
Neuroticism (2016)	0.9	1.3	2.2	-1.5	-0.7
Diabetes (mother)	0.9	1.2	1.8	-1.3	-0.7
Fluid intelligence score	0.9	2.0	2.2	-1.3	-1.5
Weight	0.9	4.4	6.3	2.5	1.6
Falls in the last year	0.9	1.2	2.4	-0.1	-1.5
Happiness	0.9	1.1	2.1	1.4	-0.0
Illnesses of mother	0.9	1.1	1.1	1.1	1.1
Body fat percentage	0.9	3.6	4.2	1.7	2.1
Medication: Blood pressure	0.9	1.5	2.1	-1.5	-0.9
Whole body fat mass	0.9	3.8	3.9	2.0	1.9
Alcohol intake frequency.	0.9	2.1	4.1	0.1	2.0
Medication: Metformin	0.8	1.1	1.8	-1.4	-0.6
Alcohol usually taken with meals	0.8	1.3	2.0	-1.4	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.0	-0.8	-1.4
Neck or shoulder pain in last month	0.8	1.2	2.2	-0.4	-1.5
Medication: Omeprazole	0.8	1.0	1.9	-0.3	1.4
Medication for cholesterol	0.8	1.2	2.4	0.1	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.8	0.4	-1.3
Breast cancer (self-reported)	0.8	1.0	1.9	-1.4	-0.3
Osteoporosis (self-reported)	0.8	1.0	1.4	1.2	-0.8
Lupus	0.7	1.0	1.2	1.1	0.9
Relative age voice broke	0.7	1.1	1.9	-0.6	-1.4
Trunk fat mass	0.7	3.0	4.1	2.0	1.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	1.3	0.4
Prospective memory result	0.7	0.9	1.7	0.2	1.3
Length of working week for main job	0.7	0.8	1.1	1.1	-0.7
Birth weight of first child	0.7	1.2	2.3	-0.3	1.5
Medication: Paracetamol	0.7	1.2	2.1	-0.5	-1.5
Worry too long after embarrassment	0.7	1.2	2.4	1.6	0.2
Arm predicted mass (right)	0.7	3.4	5.2	2.3	1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	-0.3	1.3
Supplements: Vitamin C	0.7	0.9	1.7	-0.0	1.3
Average weekly red wine intake	0.7	1.1	2.1	-0.2	1.4
Mineral and other dietary supplements	0.7	1.0	1.4	-0.8	-1.2
Miserableness	0.7	1.3	2.4	0.3	-1.6
Myopia	0.7	1.0	1.6	-0.6	1.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.5	-0.4	1.2
Ulcerative Colitis (UC)	0.6	1.1	1.7	1.3	-0.8
Blood Platelet Count	0.6	6.7	13.3	0.4	-3.6
Hypothyroidism (self reported)	0.6	1.3	1.5	-1.2	1.1
Leg fat-free mass (left)	0.6	3.0	4.5	2.1	1.2
Trunk fat percentage	0.6	2.4	3.3	1.8	1.2
Fed-up feelings	0.6	1.1	2.1	0.1	-1.4
Serious illness, injury or assault to yourself	0.6	0.8	1.0	1.0	-0.7
Medication: Levothyroxine sodium	0.6	1.0	1.8	0.4	1.4
Leg predicted mass (left)	0.6	3.0	4.8	2.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.8	1.3	-0.3
Pulse rate	0.6	1.0	1.9	1.4	0.2
Blood clot in the leg (DVT)	0.6	0.7	0.9	1.0	-0.7
Headache pain in last month	0.6	1.0	2.1	0.0	-1.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.4	-1.0	1.2
Commuting to job workplace: Public transport	0.6	0.8	1.2	0.5	1.1
Alcohol drinker status: Never	0.6	0.8	1.1	0.7	1.0
Basal metabolic rate	0.6	3.4	5.5	2.3	1.1
Arm fat-free mass (left)	0.6	2.9	4.5	2.1	1.2
Pain experienced in last month	0.6	0.9	1.8	0.2	1.4
Coronary Artery Disease (CAD)	0.5	0.5	1.1	-1.0	0.0
Fasting Glucose	0.5	0.6	0.9	-0.9	0.6
Tanning	0.5	6.5	9.1	3.0	2.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.2	1.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.2	-1.1	0.2
Supplements: Zinc	0.5	0.6	1.2	-0.1	1.1
Medication: Co-codamol	0.5	0.6	0.8	-0.9	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.7	0.8	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	0.9	-0.3
High blood pressure	0.5	1.3	2.5	-1.6	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.8	-0.8	-0.9
Medication: Amlodipine	0.5	0.7	1.3	-1.1	-0.1
Forced vital capacity (FVC), Best measure	0.5	1.7	2.4	1.5	-1.0
Arm fat-free mass (right)	0.5	2.6	3.6	1.9	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.1	-0.1	1.0
Emphysema/chronic bronchitis	0.5	0.6	0.8	0.9	-0.7
Whole body fat-free mass	0.5	2.6	4.4	2.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.8	-0.5	-0.9
Whole body water mass	0.5	2.8	4.8	2.2	0.9
Fractured/broken bones in last 5 years	0.5	0.6	1.0	-0.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.1	1.1	0.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.7	1.3	0.3
High blood pressure (mother)	0.4	0.5	0.5	-0.7	-0.7
Forced vital capacity (FVC)	0.4	1.7	2.2	1.5	-1.0
Alcohol intake versus 10 years previously	0.4	0.6	1.3	0.1	1.1
Number of live births	0.4	0.6	0.8	0.5	0.9
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.8	-0.4	-1.3
Lung cancer (father)	0.4	0.5	0.6	-0.8	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	1.6	1.3	0.5
Birth weight	0.4	1.0	1.1	1.1	0.9
Medication: Ibuprofen	0.4	0.5	0.7	0.5	-0.8
Comparative height size at age 10	0.4	2.1	3.5	0.8	-1.9
Hypertension (Self-reported)	0.4	1.1	2.1	-1.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	0.1	1.0
Leg fat-free mass (right)	0.4	2.3	3.9	2.0	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	-0.5	-1.1
Leg predicted mass (right)	0.4	2.4	4.0	2.0	0.9
Age started oral contraceptive pill	0.4	0.4	0.7	0.8	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.2	1.5	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	-1.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.7	0.7	-0.8
Arm predicted mass (left)	0.4	2.1	3.2	1.8	1.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.7	0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.5	-0.3	-0.7
Heel T-Score	0.3	2.5	4.6	-2.1	0.7
Hair Pigment	0.3	8.9	17.6	-4.2	-0.3
Taking other prescription medications	0.3	0.5	1.0	1.0	0.3
Medication: Atenolol	0.3	0.4	0.7	-0.9	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.5	0.7	-0.7
Had menopause	0.3	0.3	0.6	-0.2	0.8
Neuroticism score	0.3	0.7	0.8	0.9	-0.7
Trunk fat-free mass	0.3	1.7	3.2	1.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.1	-0.9
Trunk predicted mass	0.3	1.8	3.2	1.8	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	-0.4	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	-0.3	1.0
Heart disease (mother)	0.3	0.3	0.7	-0.2	-0.8
Age at last live birth	0.3	0.5	1.0	1.0	0.0
Leg pain on walking	0.3	0.3	0.6	0.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	0.4	0.7
Illnesses of father: Heart disease	0.3	0.5	0.7	-0.8	-0.6
Friendships satisfaction	0.3	0.4	0.8	0.9	-0.2
Osteoarthritis (self-reported)	0.3	0.4	0.5	0.6	0.7
Medication: Aspirin	0.3	0.4	0.7	-0.8	-0.2
Heart disease (siblings)	0.3	0.4	0.5	-0.7	0.5
Neuroticism (Nagel 2018)	0.2	0.4	0.7	-0.2	-0.8
Schizophrenia (2018)	0.2	0.4	0.7	0.8	-0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.7	0.3
HDL Cholesterol	0.2	0.3	0.6	0.8	0.0
Schizophrenia (2014)	0.2	0.4	0.8	0.9	0.0
Triglycerides	0.2	0.4	0.8	-0.9	0.0
Ulcerative Colitis	0.2	0.3	0.6	0.8	0.0
Blood Eosinophil Count	0.2	1.4	1.5	1.2	1.2
Allergy or Eczema	0.2	0.6	0.8	0.9	-0.6
Cardiovascular Disease	0.2	0.7	0.8	-0.9	0.7
Neuroticism	0.2	0.6	0.6	0.7	-0.8
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.6	0.0
Current tobacco smoking	0.2	0.3	0.5	0.7	-0.4
Multivitamins +/- minerals	0.2	0.2	0.3	-0.6	-0.4
Past tobacco smoking	0.2	0.3	0.5	-0.4	-0.7
Nervous feelings	0.2	0.4	0.5	0.7	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.6	-0.1
Heart attack	0.2	0.3	0.6	-0.8	0.1
Pain all over the body in last month	0.2	0.3	0.5	0.7	-0.0
Worrier / anxious feelings	0.2	0.3	0.5	0.2	0.7
Noisy workplace	0.2	0.3	0.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.7	0.6	-0.8
Breastfed as a baby	0.2	0.3	0.3	0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.4	-0.7	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	-0.3
Age at first live birth	0.2	0.4	0.5	0.7	0.4
Shortness of breath walking on level ground	0.2	0.3	0.3	0.5	-0.6
Medication: Aspirin	0.2	0.2	0.4	-0.6	0.2
Mood swings	0.2	0.3	0.6	0.3	-0.8
Smoking status: Current	0.2	0.3	0.4	0.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.6	0.8	0.6
Mother’s age at death	0.2	0.3	0.5	0.7	0.3
Medication: Blood pressure	0.2	0.4	0.8	-0.2	0.9
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	-0.0
Average weekly beer plus cider intake	0.2	0.2	0.5	-0.1	-0.7
Irritability	0.2	0.3	0.5	0.1	-0.7
Diastolic blood pressure, automated reading	0.2	0.5	0.8	0.9	0.5
Bipolar Disorder or Schizophrenia	0.1	0.4	0.7	0.8	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.1	-0.6
Worry (Nagel 2018)	0.1	0.3	0.5	0.7	0.3
Age at First Birth	0.1	0.1	0.2	-0.1	-0.4
Number of treatments/medications taken	0.1	0.1	0.2	0.4	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.2	-0.4
Vitamin and mineral supplements	0.1	0.1	0.2	-0.2	-0.4
Pack years adult smoking proportion	0.1	0.1	0.2	-0.1	0.4
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.1	-0.3	0.4
Supplements: Glucosamine	0.1	0.1	0.2	-0.0	-0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	-0.5	0.1
Medication: Ramipril	0.1	0.2	0.2	0.3	0.5
Time employed in main current job	0.1	0.1	0.1	0.4	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.3	0.5	-0.6
Loud music exposure frequency	0.1	0.1	0.1	0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.6	-0.1
Qualifications: College or University degree	0.1	0.4	0.5	-0.6	-0.7
Medication: Allopurinol	0.1	0.1	0.2	-0.2	0.5
Had major operations	0.1	0.1	0.1	0.3	-0.4
Knee pain experienced in last month	0.1	0.1	0.3	-0.0	0.5
Smoking status: Previous	0.1	0.2	0.2	0.4	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.5	0.1
Loneliness, isolation	0.1	0.1	0.2	0.1	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.4	-0.1
Ever smoked	0.1	0.2	0.4	0.2	0.6
Ever depressed for a whole week	0.1	0.2	0.2	0.4	0.4
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.3
Supplements: Calcium	0.1	0.1	0.3	0.0	0.5
Bipolar Disorder (2018)	0.0	0.1	0.1	0.3	0.2
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.0	0.3
Breast Cancer	0.0	0.1	0.1	-0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	0.0
Mean Putamen Volume	0.0	0.0	0.1	-0.1	0.3
Smoking Status	0.0	0.0	0.1	-0.1	-0.3
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	0.2	0.3
Qualifications: None of the above	0.0	0.1	0.2	-0.0	0.4
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.3	0.0
Gout (self-reported)	0.0	0.0	0.0	-0.2	0.1
Number of full brothers	0.0	0.0	0.0	0.1	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.0	0.1	0.0
Pack years of smoking	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

HOXB7

Models

Trait associations