[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr17:36,211,659-39,048,774

Best TWAS P=2.19e-37 · Best GWAS P=3.08e-31 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Cells Transformed fibroblasts	PCGF2	0.34	0.28	lasso	4	0.30	3.2e-23	-11.62	-12.8	2.2e-37	0.94	0.00	1.00	TRUE
10	GTEx	Artery Tibial	PCGF2	0.38	0.27	lasso	8	0.31	4.3e-25	-11.62	-12.4	4.6e-35	0.95	0.00	1.00	TRUE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PCGF2	0.08	0.00	blup	37	0.01	3.8e-02	-9.61	-10.0	1.2e-23	0.71	0.00	0.69	TRUE
13	GTEx	Artery Tibial	MSL1	0.19	0.14	lasso	2	0.15	4.9e-12	-8.69	9.2	2.7e-20	-0.01	0.00	1.00	TRUE
26	GTEx	Esophagus Muscularis	MSL1	0.25	0.18	lasso	8	0.22	1.7e-13	-8.25	8.3	7.8e-17	0.00	0.01	0.99	TRUE
41	GTEx	Testis	MSL1	0.23	0.05	enet	9	0.15	2.9e-07	-8.69	8.0	1.0e-15	0.04	0.00	1.00	TRUE
4	GTEx	Adipose Subcutaneous	PIP4K2B	0.15	0.07	lasso	5	0.07	2.2e-06	7.11	7.3	3.4e-13	-0.17	0.98	0.00	TRUE
15	GTEx	Brain Cerebellum	CWC25	0.30	0.01	enet	9	0.02	1.0e-01	3.22	6.4	1.4e-10	-0.24	0.06	0.06	TRUE
49	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	4.85	6.1	1.2e-09	0.02	1.00	0.00	TRUE
37	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	-5.19	-5.9	3.1e-09	-0.03	1.00	0.00	TRUE
17	GTEx	Breast Mammary Tissue	ORMDL3	0.17	0.04	enet	27	0.06	7.2e-04	3.24	5.9	4.1e-09	0.04	0.45	0.12	TRUE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	4.72	-5.6	1.8e-08	-0.01	0.03	0.96	TRUE
52	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	-4.75	-5.3	1.0e-07	0.01	1.00	0.00	TRUE
3	GTEx	Adipose Subcutaneous	THRA	0.12	0.00	enet	23	0.02	1.6e-02	5.11	-5.3	1.2e-07	-0.01	0.06	0.42	TRUE
71	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PCGF2	0.28	0.16	lasso	4	0.13	3.4e-06	-11.62	-12.5	6.0e-36	0.97	0.00	1.00	FALSE
6	GTEx	Adrenal Gland	PCGF2	0.34	0.09	lasso	6	0.11	8.5e-05	-11.62	-12.5	9.0e-36	0.87	0.00	0.99	FALSE
24	GTEx	Esophagus Mucosa	PCGF2	0.32	0.24	lasso	7	0.23	1.8e-15	-11.62	-12.4	2.0e-35	0.97	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PCGF2	0.14	0.06	blup	35	0.11	1.1e-09	-9.66	-12.3	7.8e-35	0.82	0.00	1.00	FALSE
31	GTEx	Pancreas	PCGF2	0.29	0.12	lasso	5	0.07	5.3e-04	-11.62	-12.1	6.9e-34	0.96	0.00	0.98	FALSE
7	GTEx	Artery Aorta	PCGF2	0.51	0.32	enet	27	0.37	1.2e-21	-11.62	-12.1	8.0e-34	0.82	0.00	1.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	PCGF2	0.36	0.30	lasso	7	0.32	1.3e-26	-11.62	-12.0	4.8e-33	0.97	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	PCGF2	0.18	0.14	lasso	4	0.16	2.4e-16	-11.62	-12.0	5.9e-33	0.94	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PCGF2	0.24	0.15	lasso	5	0.18	2.2e-19	-11.62	-11.9	9.9e-33	0.93	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	PCGF2	0.06	0.06	blup	37	0.05	4.4e-11	-11.62	-11.9	1.2e-32	0.85	0.00	1.00	FALSE
22	GTEx	Colon Transverse	PCGF2	0.29	0.21	lasso	5	0.20	6.2e-10	-11.62	-11.9	1.5e-32	1.00	0.00	1.00	FALSE
28	GTEx	Lung	PCGF2	0.25	0.17	lasso	7	0.17	4.8e-13	-11.62	-11.9	1.9e-32	0.97	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	PCGF2	0.08	0.05	enet	11	0.08	3.8e-09	-9.61	-11.8	2.2e-32	0.78	0.04	0.96	FALSE
1	GTEx	Adipose Subcutaneous	PCGF2	0.14	0.12	lasso	2	0.12	6.1e-10	-11.62	-11.7	7.5e-32	0.98	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	PCGF2	0.23	0.23	lasso	3	0.22	9.8e-13	-11.62	-11.7	8.5e-32	0.99	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PCGF2	0.05	0.03	lasso	3	0.04	1.0e-05	-9.61	-11.7	1.3e-31	0.89	0.00	1.00	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	PCGF2	0.39	0.23	lasso	4	0.21	6.9e-12	-11.62	-11.7	2.1e-31	1.00	0.00	1.00	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	PCGF2	0.27	0.22	enet	9	0.25	1.4e-24	-11.62	-11.7	2.2e-31	0.88	0.00	1.00	FALSE
75	The Cancer Genome Atlas	Soft Tissue Sarcoma	PCGF2	0.18	0.05	blup	36	0.11	7.3e-07	-9.41	-11.6	6.2e-31	0.71	0.00	0.99	FALSE
27	GTEx	Heart Atrial Appendage	PCGF2	0.18	0.13	lasso	3	0.09	6.1e-05	-11.62	-11.5	1.1e-30	1.00	0.00	1.00	FALSE
46	METSIM	Adipose	PCGF2	0.05	0.04	lasso	4	0.02	3.7e-04	-10.97	-11.5	1.8e-30	0.63	0.01	0.98	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	PCGF2	0.14	0.04	enet	8	0.16	6.8e-12	4.14	-11.3	8.3e-30	0.76	0.00	1.00	FALSE
53	YFS	Blood	PCGF2	0.03	0.02	enet	7	0.03	2.1e-11	-11.62	-11.3	2.0e-29	0.79	0.00	1.00	FALSE
25	GTEx	Esophagus Muscularis	PCGF2	0.21	0.15	lasso	8	0.13	3.3e-08	-11.62	-11.1	1.9e-28	0.96	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PCGF2	0.11	0.00	blup	37	0.03	1.0e-02	4.96	-10.7	7.0e-27	0.57	0.00	0.51	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PCGF2	0.13	0.06	blup	37	0.09	7.0e-10	-11.62	-10.7	1.2e-26	0.85	0.00	1.00	FALSE
14	GTEx	Brain Cerebellum	PCGF2	0.25	0.29	lasso	3	0.26	2.4e-08	-9.66	10.4	2.2e-25	-0.83	0.01	0.99	FALSE
29	GTEx	Nerve Tibial	PCGF2	0.20	0.07	lasso	4	0.13	3.1e-09	4.14	-10.2	1.2e-24	0.74	0.00	1.00	FALSE
69	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CISD3	0.11	0.06	blup	33	0.04	1.9e-03	-9.66	10.1	5.3e-24	-0.78	0.01	0.95	FALSE
30	GTEx	Nerve Tibial	MSL1	0.33	0.25	lasso	4	0.24	6.3e-17	-8.69	9.1	7.9e-20	-0.01	0.00	1.00	FALSE
23	GTEx	Colon Transverse	MSL1	0.18	0.11	lasso	3	0.05	2.1e-03	-8.69	9.1	1.0e-19	-0.01	0.00	0.99	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PIP4K2B	0.04	0.01	blup	56	0.03	6.3e-04	7.59	8.9	3.6e-19	-0.43	0.05	0.05	FALSE
5	GTEx	Adipose Subcutaneous	MSL1	0.15	0.12	lasso	2	0.12	3.9e-10	-8.69	8.7	4.2e-18	-0.01	0.00	1.00	FALSE
36	GTEx	Skin Sun Exposed Lower leg	MSL1	0.08	0.04	lasso	2	0.05	8.1e-05	-7.19	8.6	7.4e-18	0.00	0.00	0.99	FALSE
45	METSIM	Adipose	MSL1	0.12	0.06	lasso	10	0.06	1.8e-09	-8.69	8.6	7.4e-18	0.00	0.00	1.00	FALSE
18	GTEx	Breast Mammary Tissue	MSL1	0.20	0.06	lasso	6	0.07	2.2e-04	-8.69	8.6	1.1e-17	-0.03	0.00	1.00	FALSE
32	GTEx	Pituitary	MSL1	0.40	0.27	lasso	7	0.24	1.3e-06	-8.00	8.3	6.6e-17	0.00	0.03	0.88	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	MSL1	0.18	0.15	lasso	4	0.15	2.1e-08	-8.69	8.2	3.5e-16	-0.02	0.00	1.00	FALSE
39	GTEx	Testis	LASP1	0.35	0.20	lasso	5	0.20	2.4e-09	-7.53	-7.8	7.3e-15	0.40	1.00	0.00	FALSE
42	GTEx	Testis	RP1-56K13.3	0.27	0.10	lasso	8	0.08	1.7e-04	-7.53	-7.7	1.3e-14	0.41	0.72	0.02	FALSE
19	GTEx	Breast Mammary Tissue (Female)	MSL1	0.09	0.00	enet	9	0.03	5.8e-02	-8.69	7.6	3.3e-14	-0.04	0.01	0.80	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PSMB3	0.12	0.09	lasso	3	0.06	3.0e-03	7.59	7.6	3.9e-14	-0.22	0.05	0.06	FALSE
40	GTEx	Testis	PSMB3	0.30	0.24	lasso	4	0.21	8.9e-10	7.11	7.2	7.7e-13	-0.19	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	PSMB3	0.05	0.06	lasso	1	0.05	2.4e-05	7.11	7.1	1.2e-12	-0.19	0.50	0.03	FALSE
2	GTEx	Adipose Subcutaneous	PSMB3	0.11	0.01	enet	8	0.03	2.7e-03	6.29	6.8	1.0e-11	-0.31	0.24	0.04	FALSE
21	GTEx	Cells Transformed fibroblasts	GSDMB	0.11	0.02	enet	18	0.06	4.9e-05	-4.87	-6.8	1.1e-11	-0.01	0.84	0.08	FALSE
50	NTR	Blood	PIP4K2B	0.02	0.01	lasso	3	0.01	6.4e-04	7.11	-6.7	1.8e-11	0.18	0.27	0.03	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	PIP4K2B	0.05	0.04	blup	56	0.05	5.3e-06	6.82	6.5	1.1e-10	-0.18	0.57	0.02	FALSE
8	GTEx	Artery Aorta	PSMB3	0.23	0.17	enet	26	0.22	2.1e-12	7.11	6.2	6.9e-10	-0.17	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RAPGEFL1	0.13	0.02	enet	9	0.06	4.3e-04	-6.77	6.2	7.0e-10	-0.03	0.04	0.21	FALSE
12	GTEx	Artery Tibial	PIP4K2B	0.37	0.16	enet	49	0.22	2.1e-17	7.11	6.1	1.2e-09	-0.06	1.00	0.00	FALSE
55	YFS	Blood	PSMB3	0.14	0.11	enet	31	0.16	7.2e-49	7.59	5.9	3.9e-09	-0.13	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PSMB3	0.04	0.00	blup	37	0.02	6.7e-03	5.42	5.7	1.1e-08	-0.18	0.04	0.05	FALSE
11	GTEx	Artery Tibial	PSMB3	0.10	0.02	enet	12	0.03	1.2e-03	7.11	5.7	1.5e-08	-0.21	0.59	0.05	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	4.82	5.7	1.6e-08	0.01	0.07	0.51	FALSE
54	YFS	Blood	PIP4K2B	0.03	0.00	bslmm	348	0.01	6.5e-03	1.44	-5.7	1.6e-08	0.27	0.06	0.27	FALSE
43	GTEx	Thyroid	CTB-58E17.3	0.11	0.00	enet	45	0.02	2.3e-02	0.25	-5.6	1.7e-08	0.36	0.10	0.43	FALSE
48	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	-5.05	-5.4	5.2e-08	0.00	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	4.72	-5.4	5.9e-08	-0.02	0.02	0.60	FALSE
38	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	-5.19	-5.3	1.1e-07	-0.04	0.99	0.00	FALSE
9	GTEx	Artery Tibial	LASP1	0.11	0.00	enet	13	0.04	6.9e-04	-7.88	-5.3	1.3e-07	0.37	0.08	0.11	FALSE
44	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	-5.19	-5.3	1.3e-07	-0.02	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	5.08	-5.3	1.3e-07	-0.03	0.02	0.85	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	-5.12	-5.3	1.4e-07	-0.03	0.02	0.97	FALSE
51	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	-4.75	-5.2	1.5e-07	0.00	1.00	0.00	FALSE
47	METSIM	Adipose	PIP4K2B	0.06	0.01	blup	360	0.02	7.0e-04	5.42	5.2	1.6e-07	-0.19	0.47	0.04	FALSE