[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr17:36,211,659-39,048,774

Best TWAS P=2.19e-37 · Best GWAS P=3.08e-31 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PCGF2 0.14 0.12 lasso 2 0.12 6.1e-10 -11.62 -11.7 7.5e-32 0.98 0.00 1.00 FALSE
2 GTEx Adipose Subcutaneous PSMB3 0.11 0.01 enet 8 0.03 2.7e-03 6.29 6.8 1.0e-11 -0.31 0.24 0.04 FALSE
3 GTEx Adipose Subcutaneous THRA 0.12 0.00 enet 23 0.02 1.6e-02 5.11 -5.3 1.2e-07 -0.01 0.06 0.42 TRUE
4 GTEx Adipose Subcutaneous PIP4K2B 0.15 0.07 lasso 5 0.07 2.2e-06 7.11 7.3 3.4e-13 -0.17 0.98 0.00 TRUE
5 GTEx Adipose Subcutaneous MSL1 0.15 0.12 lasso 2 0.12 3.9e-10 -8.69 8.7 4.2e-18 -0.01 0.00 1.00 FALSE
6 GTEx Adrenal Gland PCGF2 0.34 0.09 lasso 6 0.11 8.5e-05 -11.62 -12.5 9.0e-36 0.87 0.00 0.99 FALSE
7 GTEx Artery Aorta PCGF2 0.51 0.32 enet 27 0.37 1.2e-21 -11.62 -12.1 8.0e-34 0.82 0.00 1.00 FALSE
8 GTEx Artery Aorta PSMB3 0.23 0.17 enet 26 0.22 2.1e-12 7.11 6.2 6.9e-10 -0.17 1.00 0.00 FALSE
9 GTEx Artery Tibial LASP1 0.11 0.00 enet 13 0.04 6.9e-04 -7.88 -5.3 1.3e-07 0.37 0.08 0.11 FALSE
10 GTEx Artery Tibial PCGF2 0.38 0.27 lasso 8 0.31 4.3e-25 -11.62 -12.4 4.6e-35 0.95 0.00 1.00 TRUE
11 GTEx Artery Tibial PSMB3 0.10 0.02 enet 12 0.03 1.2e-03 7.11 5.7 1.5e-08 -0.21 0.59 0.05 FALSE
12 GTEx Artery Tibial PIP4K2B 0.37 0.16 enet 49 0.22 2.1e-17 7.11 6.1 1.2e-09 -0.06 1.00 0.00 FALSE
13 GTEx Artery Tibial MSL1 0.19 0.14 lasso 2 0.15 4.9e-12 -8.69 9.2 2.7e-20 -0.01 0.00 1.00 TRUE
14 GTEx Brain Cerebellum PCGF2 0.25 0.29 lasso 3 0.26 2.4e-08 -9.66 10.4 2.2e-25 -0.83 0.01 0.99 FALSE
15 GTEx Brain Cerebellum CWC25 0.30 0.01 enet 9 0.02 1.0e-01 3.22 6.4 1.4e-10 -0.24 0.06 0.06 TRUE
16 GTEx Brain Nucleus accumbens basal ganglia RAPGEFL1 0.16 0.06 lasso 4 0.07 7.7e-03 4.82 5.7 1.6e-08 0.01 0.07 0.51 FALSE
17 GTEx Breast Mammary Tissue ORMDL3 0.17 0.04 enet 27 0.06 7.2e-04 3.24 5.9 4.1e-09 0.04 0.45 0.12 TRUE
18 GTEx Breast Mammary Tissue MSL1 0.20 0.06 lasso 6 0.07 2.2e-04 -8.69 8.6 1.1e-17 -0.03 0.00 1.00 FALSE
19 GTEx Breast Mammary Tissue (Female) MSL1 0.09 0.00 enet 9 0.03 5.8e-02 -8.69 7.6 3.3e-14 -0.04 0.01 0.80 FALSE
20 GTEx Cells Transformed fibroblasts PCGF2 0.34 0.28 lasso 4 0.30 3.2e-23 -11.62 -12.8 2.2e-37 0.94 0.00 1.00 TRUE
21 GTEx Cells Transformed fibroblasts GSDMB 0.11 0.02 enet 18 0.06 4.9e-05 -4.87 -6.8 1.1e-11 -0.01 0.84 0.08 FALSE
22 GTEx Colon Transverse PCGF2 0.29 0.21 lasso 5 0.20 6.2e-10 -11.62 -11.9 1.5e-32 1.00 0.00 1.00 FALSE
23 GTEx Colon Transverse MSL1 0.18 0.11 lasso 3 0.05 2.1e-03 -8.69 9.1 1.0e-19 -0.01 0.00 0.99 FALSE
24 GTEx Esophagus Mucosa PCGF2 0.32 0.24 lasso 7 0.23 1.8e-15 -11.62 -12.4 2.0e-35 0.97 0.00 1.00 FALSE
25 GTEx Esophagus Muscularis PCGF2 0.21 0.15 lasso 8 0.13 3.3e-08 -11.62 -11.1 1.9e-28 0.96 0.00 1.00 FALSE
26 GTEx Esophagus Muscularis MSL1 0.25 0.18 lasso 8 0.22 1.7e-13 -8.25 8.3 7.8e-17 0.00 0.01 0.99 TRUE
27 GTEx Heart Atrial Appendage PCGF2 0.18 0.13 lasso 3 0.09 6.1e-05 -11.62 -11.5 1.1e-30 1.00 0.00 1.00 FALSE
28 GTEx Lung PCGF2 0.25 0.17 lasso 7 0.17 4.8e-13 -11.62 -11.9 1.9e-32 0.97 0.00 1.00 FALSE
29 GTEx Nerve Tibial PCGF2 0.20 0.07 lasso 4 0.13 3.1e-09 4.14 -10.2 1.2e-24 0.74 0.00 1.00 FALSE
30 GTEx Nerve Tibial MSL1 0.33 0.25 lasso 4 0.24 6.3e-17 -8.69 9.1 7.9e-20 -0.01 0.00 1.00 FALSE
31 GTEx Pancreas PCGF2 0.29 0.12 lasso 5 0.07 5.3e-04 -11.62 -12.1 6.9e-34 0.96 0.00 0.98 FALSE
32 GTEx Pituitary MSL1 0.40 0.27 lasso 7 0.24 1.3e-06 -8.00 8.3 6.6e-17 0.00 0.03 0.88 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic PCGF2 0.39 0.23 lasso 4 0.21 6.9e-12 -11.62 -11.7 2.1e-31 1.00 0.00 1.00 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic MSL1 0.18 0.15 lasso 4 0.15 2.1e-08 -8.69 8.2 3.5e-16 -0.02 0.00 1.00 FALSE
35 GTEx Skin Sun Exposed Lower leg PCGF2 0.36 0.30 lasso 7 0.32 1.3e-26 -11.62 -12.0 4.8e-33 0.97 0.00 1.00 FALSE
36 GTEx Skin Sun Exposed Lower leg MSL1 0.08 0.04 lasso 2 0.05 8.1e-05 -7.19 8.6 7.4e-18 0.00 0.00 0.99 FALSE
37 GTEx Spleen GSDMB 0.50 0.45 enet 14 0.43 1.9e-12 -5.19 -5.9 3.1e-09 -0.03 1.00 0.00 TRUE
38 GTEx Spleen ORMDL3 0.40 0.44 enet 11 0.39 5.7e-11 -5.19 -5.3 1.1e-07 -0.04 0.99 0.00 FALSE
39 GTEx Testis LASP1 0.35 0.20 lasso 5 0.20 2.4e-09 -7.53 -7.8 7.3e-15 0.40 1.00 0.00 FALSE
40 GTEx Testis PSMB3 0.30 0.24 lasso 4 0.21 8.9e-10 7.11 7.2 7.7e-13 -0.19 1.00 0.00 FALSE
41 GTEx Testis MSL1 0.23 0.05 enet 9 0.15 2.9e-07 -8.69 8.0 1.0e-15 0.04 0.00 1.00 TRUE
42 GTEx Testis RP1-56K13.3 0.27 0.10 lasso 8 0.08 1.7e-04 -7.53 -7.7 1.3e-14 0.41 0.72 0.02 FALSE
43 GTEx Thyroid CTB-58E17.3 0.11 0.00 enet 45 0.02 2.3e-02 0.25 -5.6 1.7e-08 0.36 0.10 0.43 FALSE
44 GTEx Whole Blood ORMDL3 0.18 0.12 lasso 5 0.14 1.8e-12 -5.19 -5.3 1.3e-07 -0.02 1.00 0.00 FALSE
45 METSIM Adipose MSL1 0.12 0.06 lasso 10 0.06 1.8e-09 -8.69 8.6 7.4e-18 0.00 0.00 1.00 FALSE
46 METSIM Adipose PCGF2 0.05 0.04 lasso 4 0.02 3.7e-04 -10.97 -11.5 1.8e-30 0.63 0.01 0.98 FALSE
47 METSIM Adipose PIP4K2B 0.06 0.01 blup 360 0.02 7.0e-04 5.42 5.2 1.6e-07 -0.19 0.47 0.04 FALSE
48 NTR Blood GSDMB 0.09 0.10 enet 16 0.12 3.8e-36 -5.05 -5.4 5.2e-08 0.00 1.00 0.00 FALSE
49 NTR Blood IKZF3 0.04 0.03 blup 319 0.02 1.5e-08 4.85 6.1 1.2e-09 0.02 1.00 0.00 TRUE
50 NTR Blood PIP4K2B 0.02 0.01 lasso 3 0.01 6.4e-04 7.11 -6.7 1.8e-11 0.18 0.27 0.03 FALSE
51 YFS Blood GSDMB 0.36 0.41 lasso 12 0.49 4.0e-186 -4.75 -5.2 1.5e-07 0.00 1.00 0.00 FALSE
52 YFS Blood ORMDL3 0.31 0.36 lasso 9 0.45 2.2e-165 -4.75 -5.3 1.0e-07 0.01 1.00 0.00 TRUE
53 YFS Blood PCGF2 0.03 0.02 enet 7 0.03 2.1e-11 -11.62 -11.3 2.0e-29 0.79 0.00 1.00 FALSE
54 YFS Blood PIP4K2B 0.03 0.00 bslmm 348 0.01 6.5e-03 1.44 -5.7 1.6e-08 0.27 0.06 0.27 FALSE
55 YFS Blood PSMB3 0.14 0.11 enet 31 0.16 7.2e-49 7.59 5.9 3.9e-09 -0.13 1.00 0.00 FALSE
56 The Cancer Genome Atlas Bladder Urothelial Carcinoma PCGF2 0.14 0.06 blup 35 0.11 1.1e-09 -9.66 -12.3 7.8e-35 0.82 0.00 1.00 FALSE
57 The Cancer Genome Atlas Bladder Urothelial Carcinoma PSMB3 0.04 0.00 blup 37 0.02 6.7e-03 5.42 5.7 1.1e-08 -0.18 0.04 0.05 FALSE
58 The Cancer Genome Atlas Breast Invasive Carcinoma PCGF2 0.06 0.06 blup 37 0.05 4.4e-11 -11.62 -11.9 1.2e-32 0.85 0.00 1.00 FALSE
59 The Cancer Genome Atlas Colon Adenocarcinoma GSDMB 0.10 0.15 blup 40 0.14 1.2e-08 4.72 -5.6 1.8e-08 -0.01 0.03 0.96 TRUE
60 The Cancer Genome Atlas Colon Adenocarcinoma PCGF2 0.23 0.23 lasso 3 0.22 9.8e-13 -11.62 -11.7 8.5e-32 0.99 0.00 1.00 FALSE
61 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PCGF2 0.13 0.06 blup 37 0.09 7.0e-10 -11.62 -10.7 1.2e-26 0.85 0.00 1.00 FALSE
62 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PIP4K2B 0.04 0.01 blup 56 0.03 6.3e-04 7.59 8.9 3.6e-19 -0.43 0.05 0.05 FALSE
63 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ORMDL3 0.01 0.01 blup 36 0.00 8.5e-02 4.72 -5.4 5.9e-08 -0.02 0.02 0.60 FALSE
64 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PCGF2 0.24 0.15 lasso 5 0.18 2.2e-19 -11.62 -11.9 9.9e-33 0.93 0.00 1.00 FALSE
65 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RAPGEFL1 0.13 0.02 enet 9 0.06 4.3e-04 -6.77 6.2 7.0e-10 -0.03 0.04 0.21 FALSE
66 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PCGF2 0.11 0.00 blup 37 0.03 1.0e-02 4.96 -10.7 7.0e-27 0.57 0.00 0.51 FALSE
67 The Cancer Genome Atlas Lung Adenocarcinoma PCGF2 0.08 0.05 enet 11 0.08 3.8e-09 -9.61 -11.8 2.2e-32 0.78 0.04 0.96 FALSE
68 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PCGF2 0.05 0.03 lasso 3 0.04 1.0e-05 -9.61 -11.7 1.3e-31 0.89 0.00 1.00 FALSE
69 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CISD3 0.11 0.06 blup 33 0.04 1.9e-03 -9.66 10.1 5.3e-24 -0.78 0.01 0.95 FALSE
70 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PCGF2 0.08 0.00 blup 37 0.01 3.8e-02 -9.61 -10.0 1.2e-23 0.71 0.00 0.69 TRUE
71 The Cancer Genome Atlas Pancreatic Adenocarcinoma PCGF2 0.28 0.16 lasso 4 0.13 3.4e-06 -11.62 -12.5 6.0e-36 0.97 0.00 1.00 FALSE
72 The Cancer Genome Atlas Prostate Adenocarcinoma PCGF2 0.18 0.14 lasso 4 0.16 2.4e-16 -11.62 -12.0 5.9e-33 0.94 0.00 1.00 FALSE
73 The Cancer Genome Atlas Prostate Adenocarcinoma PIP4K2B 0.05 0.04 blup 56 0.05 5.3e-06 6.82 6.5 1.1e-10 -0.18 0.57 0.02 FALSE
74 The Cancer Genome Atlas Rectum Adenocarcinoma GSDMB 0.14 0.09 blup 39 0.17 7.0e-05 5.08 -5.3 1.3e-07 -0.03 0.02 0.85 FALSE
75 The Cancer Genome Atlas Soft Tissue Sarcoma PCGF2 0.18 0.05 blup 36 0.11 7.3e-07 -9.41 -11.6 6.2e-31 0.71 0.00 0.99 FALSE
76 The Cancer Genome Atlas Stomach Adenocarcinoma GSDMB 0.06 0.08 enet 7 0.08 1.1e-06 -5.12 -5.3 1.4e-07 -0.03 0.02 0.97 FALSE
77 The Cancer Genome Atlas Stomach Adenocarcinoma PCGF2 0.14 0.04 enet 8 0.16 6.8e-12 4.14 -11.3 8.3e-30 0.76 0.00 1.00 FALSE
78 The Cancer Genome Atlas Testicular Germ Cell Tumors PSMB3 0.12 0.09 lasso 3 0.06 3.0e-03 7.59 7.6 3.9e-14 -0.22 0.05 0.06 FALSE
79 The Cancer Genome Atlas Thyroid Carcinoma PCGF2 0.27 0.22 enet 9 0.25 1.4e-24 -11.62 -11.7 2.2e-31 0.88 0.00 1.00 FALSE
80 The Cancer Genome Atlas Thyroid Carcinoma PSMB3 0.05 0.06 lasso 1 0.05 2.4e-05 7.11 7.1 1.2e-12 -0.19 0.50 0.03 FALSE