Hub : Genes

HOXB4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0946 0.0385 0.00110 0.014 NA 0.026 NA 0.030 3.1e-02 NA 0.00560 NA 0.00330
2 GTEx Whole Blood 0.1380 0.0540 0.00290 -0.002 NA -0.002 NA -0.003 6.9e-01 NA 0.65000 NA 0.81000
3 YFS Blood 0.0302 0.0111 0.00012 0.016 0.012 0.007 0.011 0.009 3.2e-06 7.3e-05 0.00160 8.6e-05 0.00041
4 TCGA Breast Invasive Carcinoma 0.0406 0.0201 0.00072 0.005 0.015 0.016 NA 0.003 3.3e-02 3.7e-04 0.00026 NA 0.05800
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0330 0.0164 0.00300 0.005 0.025 0.016 NA 0.006 9.0e-02 7.0e-04 0.00530 NA 0.06500

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.5 1.1 0.4 0.0 -0.6 0.8 1.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 0.5 0.0 -0.3 0.8 0.2
Depressed Affect (Nagel 2018) 0.8 1.6 6.1 0.9 0.0 -0.9 -0.7 -2.5
Depression (Nagel 2018) 0.7 1.0 4.4 -0.4 0.0 -0.8 0.0 -2.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.0 -1.3 0.0 0.5 -0.7 1.4
Neuroticism (Nagel 2018) 0.4 1.0 3.7 -0.0 0.0 -0.8 -0.8 -1.9
Schizophrenia (2018) 0.0 0.1 0.3 0.1 0.0 0.1 0.4 -0.6
Schizophrenia vs Biploar Disorder 0.8 1.0 3.9 -0.7 0.0 0.8 -0.4 -2.0
Worry (Nagel 2018) 0.4 0.8 1.6 -1.3 0.0 0.4 -1.1 -1.0
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 0.9 0.0 0.6 1.0 -0.6
Alzheimer’s Disease (in father) 0.3 0.3 1.1 -0.4 0.0 -0.4 -0.2 -1.0
Alzheimer’s Disease (including proxy) 0.3 0.5 1.6 0.2 0.0 1.0 0.0 -1.3
Crohns Disease (2017) 0.8 1.7 5.0 -2.2 0.0 0.4 -0.5 -1.8
Irritable Bowel Disease (IBD) 0.8 1.8 5.1 -1.8 0.0 0.7 -0.7 -2.2
Ulcerative Colitis (UC) 0.7 1.3 5.4 -0.4 0.0 0.5 -0.7 -2.3
Major Depression (MDD) 0.3 0.3 1.0 -0.3 0.0 -1.0 0.2 -0.7
Reaction Time 0.8 1.5 5.4 -0.5 0.0 -0.6 -2.3 -1.2
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.9 -0.3 0.0 -1.0 -0.2 0.7
Breast Cancer 0.2 0.4 1.4 0.4 0.0 1.2 0.6 0.3
Ovarian Cancer 6.2 8.2 19.8 -2.7 0.0 0.5 -3.7 -4.5
Prostate Cancer 0.6 0.8 2.0 0.6 0.0 1.4 0.7 1.0
Age at First Birth 0.9 1.3 3.5 -0.0 0.0 0.5 1.9 1.7
Bipolar Disorder (2011) 0.4 0.4 1.8 -0.5 0.0 -1.3 0.0 0.2
Body Mass Index (BMI) (2010) 3.4 4.7 13.7 -2.7 0.0 3.7 -1.5 -0.6
Coronary Artery Disease (CAD) 1.1 1.4 2.8 0.1 0.0 -1.2 -1.7 -1.6
Crohns Disease (2012) 1.0 1.7 3.1 -1.4 0.0 -0.3 -1.8 -1.8
Mean Putamen Volume 1.2 1.4 3.6 1.9 0.0 -0.3 1.7 0.5
Fasting Glucose 1.2 1.4 6.2 0.7 0.0 0.4 0.5 2.5
HbA1C 0.9 1.0 2.4 1.6 0.0 -0.7 0.8 1.1
HDL Cholesterol 0.0 0.1 0.3 0.2 0.0 0.1 -0.5 -0.1
LDL Cholesterol 0.6 0.9 2.5 -1.6 0.0 1.0 -0.3 -1.0
Lupus 0.3 0.5 2.1 0.3 0.0 0.5 0.2 1.5
Neuroticism (2016) 0.5 0.8 2.8 -0.0 0.0 -1.0 1.7 -0.2
Primary Biliary Cirrhosis 0.5 0.7 2.0 -1.4 0.0 0.3 0.0 -1.2
Rheumatoid Arthritis 1.1 1.5 4.5 2.1 0.0 -1.4 0.6 0.5
Schizophrenia (2014) 0.1 0.3 0.9 0.8 0.0 -0.1 0.2 -1.0
Triglycerides 0.2 0.4 0.9 -0.1 0.0 -0.9 0.4 -1.0
Type 2 Diabetes (T2D) (2012) 2.0 2.3 6.0 1.4 0.0 -1.3 1.4 2.4
Ulcerative Colitis 0.2 0.3 1.0 0.0 0.0 0.4 -0.6 -1.0
Blood Eosinophil Count 0.3 2.6 4.7 0.5 0.0 2.1 2.2 1.8
Blood Platelet Count 0.6 6.4 19.2 -0.5 0.0 2.8 4.4 2.1
Blood Red Count 3.0 28.6 60.7 -6.7 0.0 2.9 -5.4 -7.8
Blood White Count 0.3 2.6 5.1 1.9 0.0 1.9 2.3 0.5
Heel T-Score 0.1 0.7 1.8 1.3 0.0 0.2 0.3 1.4
BMI 1.2 7.2 32.7 -1.2 0.0 5.7 1.1 -0.6
Height 0.1 1.6 2.9 -0.9 0.0 1.5 -1.7 -1.5
Waist Hip Ratio (WHR) 0.8 3.5 8.4 -2.7 0.0 2.9 -1.1 -0.8
Systolic Blood Pressure 1.6 7.9 26.7 1.2 0.0 -2.5 2.4 5.2
Smoking Status 0.2 0.6 1.0 0.8 0.0 1.0 0.7 -0.8
Allergy or Eczema 0.5 1.2 3.8 -0.3 0.0 -1.0 -1.1 -1.9
Cardiovascular Disease 0.2 0.8 1.8 -1.3 0.0 0.2 -0.8 1.2
Hypothyroidism (self reported) 1.0 2.2 7.1 0.1 0.0 -2.7 -1.1 -1.7
Respiratory disease 3.2 7.0 18.8 -4.3 0.0 3.4 -2.0 -0.6
Type 2 Diabetes (T2D) (2018) 0.7 1.4 3.6 1.8 0.0 -0.2 1.9 -0.2
Lung FEV1/FVC ratio 2.1 10.5 41.0 2.6 0.0 -6.4 1.4 1.8
Lung FVC 1.5 7.5 14.8 -2.4 0.0 -1.7 -3.9 -3.7
Neuroticism 0.6 1.4 4.1 -1.2 0.0 0.7 -0.9 -2.0
Chronotype (morning person) 0.5 1.1 3.9 -0.2 0.0 -1.2 -2.0 0.4
Hair Pigment 1.3 38.3 79.9 8.3 0.0 -8.9 -5.9 -2.8
Tanning 0.5 6.4 18.2 -3.6 0.0 4.3 -0.1 0.9
Hand grip strength (left) 5.5 14.4 36.0 -6.0 0.0 2.5 -5.0 -2.2
Number of treatments/medications taken 0.1 0.1 0.5 -0.7 0.0 -0.2 -0.2 -0.1
Average weekly spirits intake 1.1 1.3 3.5 -0.7 0.0 0.2 -1.9 -1.6
Sensitivity / hurt feelings 1.2 2.1 4.8 2.2 0.0 -2.0 0.7 -1.2
Frequency of depressed mood in last 2 weeks 0.8 1.2 5.3 -0.3 0.0 -0.6 0.1 -2.3
Hearing difficulty/problems: Yes 1.5 2.3 6.0 -2.4 0.0 0.4 0.3 -2.2
Relative age of first facial hair 1.6 3.2 6.2 2.5 0.0 -2.2 -2.0 -1.0
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 2.6 -0.8 0.0 0.3 1.2 -1.6
Ever used hormone-replacement therapy (HRT) 2.2 2.9 6.5 2.5 0.0 0.1 2.2 1.6
Ever had hysterectomy (womb removed) 0.9 1.1 4.1 0.9 0.0 0.1 2.0 -0.6
Systolic blood pressure, automated reading 1.9 5.6 24.6 0.4 0.0 -0.3 1.8 5.0
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.8 1.1 0.0 -2.0 0.2 -1.5
Angina 0.7 0.9 2.2 0.9 0.0 -0.8 0.9 1.5
Medication for hormone replacement therapy 1.5 1.6 4.4 2.1 0.0 0.6 1.7 0.5
Vitamin and mineral supplements 0.2 0.3 0.9 0.1 0.0 1.0 0.7 0.3
Supplements: Zinc 0.6 0.6 2.1 1.4 0.0 -0.9 0.3 -0.2
Medication: Co-codamol 0.6 0.6 1.9 0.9 0.0 -1.4 0.4 -0.5
Medication: Metformin 0.4 0.6 1.1 1.1 0.0 0.1 0.9 0.9
Diabetes (father) 1.1 1.3 4.3 -0.0 0.0 -1.5 -0.4 -2.1
Diabetes (mother) 0.4 0.5 1.3 1.0 0.0 -1.1 0.1 -0.5
Severe depression (siblings) 0.1 0.1 0.3 0.5 0.0 -0.3 0.6 0.1
Pack years adult smoking proportion 0.0 0.0 0.1 -0.3 0.0 0.0 -0.2 0.3
Impedance of leg (right) 0.3 1.4 3.4 0.4 0.0 -1.2 1.8 1.5
Leg fat-free mass (left) 0.7 3.7 7.4 -1.7 0.0 2.7 -2.0 -2.0
Trunk fat percentage 1.1 4.5 17.7 -1.6 0.0 4.2 1.5 -0.2
Hand grip strength (right) 6.0 16.4 38.0 -6.2 0.0 2.7 -5.3 -2.9
Townsend deprivation index at recruitment 1.3 1.9 6.2 -1.5 0.0 2.5 0.7 0.4
Current tobacco smoking 0.6 1.0 2.5 0.2 0.0 1.4 1.6 -0.7
Average weekly fortified wine intake 0.4 0.5 1.1 -1.1 0.0 0.2 -0.9 0.7
Maternal smoking around birth 0.6 0.9 2.9 1.7 0.0 -1.1 0.4 -0.6
Fed-up feelings 0.7 1.3 6.4 0.2 0.0 -0.1 0.6 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 4.2 -1.1 0.0 -0.6 -0.6 -2.0
Relative age voice broke 0.5 0.8 2.4 1.5 0.0 -0.9 0.2 -0.9
Taking other prescription medications 0.5 0.8 2.7 -0.5 0.0 0.9 1.6 -0.2
Age when periods started (menarche) 0.5 1.2 2.5 1.6 0.0 -1.1 1.5 0.2
Bilateral oophorectomy (both ovaries removed) 2.8 3.2 6.9 2.5 0.0 -1.7 2.6 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 3.3 0.3 0.0 0.2 -1.8 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.3 0.6 0.0 1.1 -0.5 -0.3
Qualifications: CSEs or equivalent 1.4 1.8 4.3 0.2 0.0 -2.1 -1.3 -1.7
Serious illness, injury or assault to yourself 1.1 1.4 5.0 -1.1 0.0 0.0 0.8 -2.2
High blood pressure 0.4 1.1 4.1 -1.0 0.0 -0.2 0.5 2.0
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.6 -1.2 0.0 -0.2 -0.9 -1.6
Multivitamins +/- minerals 0.6 0.8 1.9 1.4 0.0 -1.0 0.8 0.7
Stomach or abdominal pain in last month 0.4 0.5 1.7 -0.3 0.0 -0.7 -0.3 -1.3
Supplements: Glucosamine 0.9 1.2 2.9 0.2 0.0 1.1 1.7 1.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 3.9 -0.0 0.0 -2.0 -0.1 -0.4
Medication: Atenolol 0.7 0.9 1.8 -1.4 0.0 -0.5 -0.9 1.2
Medication: Levothyroxine sodium 1.4 2.4 6.6 -1.0 0.0 -1.2 -1.8 -2.6
Sitting height 0.1 0.9 1.5 -1.2 0.0 -0.8 -1.2 -0.9
Chronic bronchitis/emphysema (father) 2.0 2.4 5.8 2.4 0.0 -1.4 1.9 0.5
High blood pressure (mother) 0.6 0.9 1.7 -1.3 0.0 -1.0 -0.8 -1.0
Body mass index (BMI) 1.0 4.3 18.9 -1.6 0.0 4.3 -0.0 -0.5
Impedance of leg (left) 0.4 2.1 5.4 0.9 0.0 -1.5 2.3 1.5
Leg predicted mass (left) 0.7 3.9 7.3 -1.8 0.0 2.7 -2.1 -2.1
Trunk fat mass 1.1 4.7 19.3 -1.8 0.0 4.4 1.0 -0.4
Waist circumference 2.4 8.8 35.7 -2.7 0.0 6.0 0.4 -0.7
Number of incorrect matches in round 0.1 0.2 0.7 -0.8 0.0 -0.6 -0.1 -0.1
Past tobacco smoking 0.2 0.4 1.6 -0.3 0.0 -1.3 0.5 -0.5
Alcohol usually taken with meals 0.3 0.5 2.0 0.4 0.0 0.1 0.5 1.4
Nervous feelings 0.1 0.3 0.9 -1.0 0.0 0.3 0.1 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.3 -0.9 0.0 0.5 0.4 -1.5
Hearing difficulty/problems with background noise 0.5 0.7 2.6 -1.0 0.0 0.0 0.2 -1.6
Hair/balding pattern: Pattern 2 0.2 0.2 0.9 0.2 0.0 0.9 -0.3 -0.4
Had menopause 0.5 0.6 1.1 0.5 0.0 1.0 0.9 0.9
Had other major operations 1.9 2.3 4.8 -1.9 0.0 2.2 1.7 0.1
Forced vital capacity (FVC) 1.4 5.4 13.0 -1.8 0.0 -1.5 -3.6 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.8 0.6 0.0 0.2 -1.3 -0.4
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 1.1 0.0 -1.3 -0.0 -0.3
Qualifications: None of the above 0.1 0.3 0.8 0.6 0.0 0.9 -0.1 0.4
Financial difficulties in last 2 years 1.3 1.7 6.8 -0.8 0.0 0.1 -1.1 -2.6
Mouth/teeth dental problems 1.1 1.7 5.5 1.3 0.0 -0.6 0.9 2.3
Heart attack 0.7 0.9 2.8 1.1 0.0 -1.7 -0.3 -0.5
Allergy 1.4 3.2 7.2 2.7 0.0 -0.8 1.8 2.2
Pain all over the body in last month 1.2 1.3 4.4 -0.6 0.0 -0.9 -0.9 -2.1
Diabetes (self-reported) 0.7 1.0 2.6 1.6 0.0 -1.2 1.0 -0.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 3.2 -0.0 0.0 -0.7 -1.8 -1.2
Medication: Ramipril 0.6 0.8 2.1 -1.5 0.0 1.3 0.2 0.1
Medication: Simvastatin 1.0 1.5 4.3 -2.1 0.0 1.1 -1.0 0.8
Fluid intelligence score 0.2 0.4 1.0 1.0 0.0 -0.4 0.8 -0.1
Illnesses of siblings 0.7 1.0 2.1 -0.7 0.0 0.8 -1.3 -1.4
Neuroticism score 0.5 1.1 4.1 -1.0 0.0 0.4 -0.3 -2.0
Weight 1.0 4.9 18.8 -2.0 0.0 4.3 -0.5 -1.2
Impedance of arm (right) 0.5 2.2 7.5 1.2 0.0 -0.9 2.7 1.0
Arm fat percentage (right) 1.1 4.5 18.5 -1.1 0.0 4.3 1.7 -0.1
Trunk fat-free mass 0.5 3.1 6.1 -1.6 0.0 2.3 -2.5 -1.3
Hip circumference 1.2 5.1 20.2 -2.1 0.0 4.5 0.3 -1.1
Time employed in main current job 0.5 0.6 2.3 -0.6 0.0 -0.3 -1.5 -0.7
Alcohol intake versus 10 years previously 0.3 0.4 1.0 -0.4 0.0 1.0 0.4 0.9
Father’s age at death 0.3 0.4 1.1 -0.8 0.0 -1.1 0.1 -0.0
Worrier / anxious feelings 0.3 0.6 1.5 -1.2 0.0 0.9 -0.4 -0.7
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 8.2 -1.6 0.0 0.7 -0.7 -2.9
Falls in the last year 0.6 0.7 1.3 1.0 0.0 0.4 1.0 -1.2
Hair/balding pattern: Pattern 3 0.5 0.7 2.3 -1.5 0.0 -0.1 -0.8 0.7
Number of live births 0.9 1.3 5.2 -0.3 0.0 2.3 0.7 -0.7
Forced expiratory volume in 1-second (FEV1) 1.9 6.3 14.9 -1.8 0.0 -2.5 -3.9 -2.6
Pulse rate 0.3 0.5 0.9 -0.8 0.0 0.9 -0.4 -0.9
Happiness 2.1 2.6 5.1 -1.9 0.0 -0.2 -2.1 -2.2
Noisy workplace 0.6 0.7 2.8 -1.7 0.0 0.0 -0.9 -0.4
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.6 -0.1 0.0 -0.6 1.9 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 3.2 0.2 0.0 -1.8 0.6 0.2
Mouth/teeth dental problems: Dentures 3.4 5.7 14.8 -2.3 0.0 2.5 -1.4 -3.8
Asthma 2.8 5.4 14.5 -3.8 0.0 3.0 -1.8 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.7 -0.8 0.0 -1.3 -0.2 -1.2
Medication: Cholesterol lowering 0.2 0.3 1.0 -0.5 0.0 0.4 -1.0 0.4
Depression (self-reported) 0.3 0.4 1.4 -1.2 0.0 -0.6 -0.3 -0.5
Medication: Lansoprazole 0.7 0.8 1.9 1.0 0.0 -1.4 0.1 0.9
Prospective memory result 0.9 1.1 2.5 0.6 0.0 0.9 1.6 1.4
Lung cancer (father) 0.4 0.5 1.8 0.2 0.0 -1.4 0.7 -0.4
Illnesses of mother 0.6 0.7 2.3 1.2 0.0 0.0 -0.0 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 8.0 16.6 -2.5 0.0 -2.7 -4.1 -3.2
Pulse wave Arterial Stiffness index 2.4 2.7 9.5 1.8 0.0 -0.8 3.1 0.8
Impedance of arm (left) 0.3 1.5 4.8 1.0 0.0 -1.2 2.2 0.1
Arm fat mass (right) 1.1 4.6 19.5 -1.6 0.0 4.4 0.5 -0.8
Trunk predicted mass 0.6 3.2 6.2 -1.6 0.0 2.3 -2.5 -1.3
Standing height 0.2 1.7 3.8 -1.5 0.0 0.5 -1.6 -1.9
Length of working week for main job 0.4 0.5 1.0 -0.9 0.0 -0.3 -0.8 -1.0
Exposure to tobacco smoke at home 1.4 1.6 2.7 1.5 0.0 -1.5 -0.9 -1.6
Breastfed as a baby 0.5 0.6 2.1 0.5 0.0 1.5 0.4 0.6
Tense / ‘highly strung’ 1.6 2.6 6.0 -2.5 0.0 1.0 -1.4 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.7 0.3 0.0 -0.8 0.8 -0.8
Hair/balding pattern: Pattern 4 0.4 1.0 2.2 -0.7 0.0 1.5 1.1 0.9
Birth weight of first child 0.2 0.3 1.3 0.1 0.0 0.0 0.5 1.1
Peak expiratory flow (PEF) 1.8 4.2 7.2 2.7 0.0 -2.2 1.9 2.3
Pulse wave reflection index 1.2 1.5 4.1 1.6 0.0 -0.9 2.0 -0.3
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.6 2.2 0.0 -1.0 0.3 -0.6
Loud music exposure frequency 0.2 0.2 0.8 0.9 0.0 0.0 -0.0 0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.8 -1.3 0.0 -0.2 -0.3 0.2
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 4.5 0.4 0.0 -2.1 -0.9 -1.3
Blood clot in the leg (DVT) 2.7 3.4 10.6 1.1 0.0 -0.9 -2.1 -3.3
Medication: Paracetamol 1.1 1.9 4.1 1.3 0.0 -1.9 2.0 -0.1
Headache pain in last month 1.0 1.8 6.8 -0.6 0.0 -1.3 0.2 -2.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.4 0.1 0.0 -0.5 -0.3 -1.2
Glaucoma (self-reported) 2.1 2.5 6.9 -1.1 0.0 0.4 -2.0 -2.6
Gout (self-reported) 0.2 0.3 1.2 -0.4 0.0 -0.5 0.3 1.1
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 6.0 -0.2 0.0 -2.5 -1.6 -1.8
Medication: Amlodipine 0.6 0.8 2.1 -0.0 0.0 0.3 1.4 1.5
Medication: Ventolin 100micrograms inhaler 2.4 3.1 6.7 -2.3 0.0 2.6 -1.1 -1.4
Birth weight 1.0 2.2 7.2 -2.7 0.0 1.3 -1.5 0.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.1 0.8 0.0 -0.3 1.4 -1.1
High blood pressure (siblings) 0.5 0.7 1.7 1.2 0.0 -1.3 -0.1 0.4
Forced vital capacity (FVC), Best measure 2.0 7.4 15.6 -2.8 0.0 -1.6 -4.0 -3.4
Body fat percentage 1.2 4.6 18.0 -1.2 0.0 4.2 1.9 0.1
Leg fat percentage (right) 1.3 4.7 18.9 -1.3 0.0 4.3 1.6 0.7
Arm fat-free mass (right) 0.7 3.4 5.1 -2.1 0.0 2.2 -2.2 -1.7
Exposure to tobacco smoke outside home 1.2 1.6 5.0 -0.9 0.0 -0.0 -1.5 -2.2
Comparative body size at age 10 0.8 2.1 5.1 -0.6 0.0 2.3 -0.4 2.2
Number of full brothers 0.4 0.5 2.0 0.0 0.0 -0.6 0.4 -1.4
Worry too long after embarrassment 2.1 3.5 13.7 -0.9 0.0 -0.0 -1.8 -3.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.5 -1.6 0.0 1.2 1.0 -1.0
Wheeze or whistling in the chest in last year 1.9 3.4 10.6 -2.2 0.0 3.2 -1.1 -0.7
Number of children fathered 1.1 1.3 2.3 -1.1 0.0 0.8 -1.5 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.5 1.2 0.0 0.3 0.2 0.1
Age at first live birth 0.2 0.4 1.1 -0.9 0.0 0.4 -0.2 1.0
Pulse wave peak to peak time 2.5 3.0 10.2 -1.7 0.0 0.7 -3.2 -1.2
Health satisfaction 4.0 5.1 12.0 -2.7 0.0 2.2 -1.2 -3.5
Shortness of breath walking on level ground 0.3 0.4 1.9 -0.2 0.0 0.0 0.2 -1.4
Qualifications: College or University degree 0.2 0.6 1.7 0.3 0.0 -1.1 0.3 1.3
Eye problems/disorders: None of the above 0.6 0.7 1.5 1.2 0.0 -0.4 1.1 0.8
Mouth/teeth dental problems: Loose teeth 1.8 2.2 4.0 1.6 0.0 -1.2 2.0 1.6
Emphysema/chronic bronchitis 0.8 0.9 2.5 -0.2 0.0 1.0 1.6 -1.0
Medication for pain relief, constipation, heartburn 0.3 0.6 2.7 0.2 0.0 0.4 -0.3 1.6
Neck or shoulder pain in last month 0.5 0.7 1.8 0.9 0.0 -1.4 0.4 -0.6
Medication: Blood pressure 0.6 1.1 3.1 0.1 0.0 0.8 1.4 1.8
Angina (self-reported) 0.6 0.7 1.8 0.8 0.0 -0.6 1.0 1.3
Migraine (self-reported) 2.4 3.0 9.4 -1.4 0.0 -0.9 -1.6 -3.1
Medication: Ibuprofen 0.7 0.9 2.2 -1.2 0.0 -0.8 -0.2 -1.5
Medication: Allopurinol 0.8 1.1 2.9 0.5 0.0 -0.2 1.5 1.7
Medication: Omeprazole 1.2 1.5 3.3 -0.2 0.0 1.4 1.8 1.5
Medication: Seretide 50 evohaler 0.4 0.4 1.2 -0.8 0.0 0.5 0.4 -1.1
Mean time to correctly identify matches 0.7 1.3 5.3 -0.9 0.0 0.3 -2.3 -0.4
Heart disease (mother) 0.6 0.7 2.0 -0.8 0.0 -0.3 -0.9 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 4.6 -2.1 0.0 1.1 -1.9 -0.2
Whole body fat mass 1.0 4.3 18.2 -1.6 0.0 4.3 0.8 -0.4
Leg fat mass (right) 1.2 4.7 20.4 -1.6 0.0 4.5 0.8 -0.0
Arm predicted mass (right) 0.8 4.3 6.1 -2.3 0.0 2.5 -2.4 -2.2
Pulse rate, automated reading 1.0 3.1 7.2 -2.7 0.0 2.7 0.5 1.1
Alcohol intake frequency. 0.3 0.6 1.9 0.8 0.0 1.4 0.7 0.2
Comparative height size at age 10 0.4 2.0 5.5 -2.4 0.0 1.2 -1.4 -1.0
Number of full sisters 0.3 0.4 0.9 -0.6 0.0 0.4 -1.0 -0.7
Suffer from ‘nerves’ 0.3 0.4 1.4 1.2 0.0 -0.8 0.2 -0.1
Overall health rating 2.4 5.1 13.9 -2.9 0.0 1.8 -0.4 -3.7
Chest pain or discomfort 2.5 3.7 8.7 -2.1 0.0 2.0 -1.0 -3.0
Had major operations 0.5 0.5 1.2 1.1 0.0 -0.7 0.4 -0.9
Age at last live birth 0.5 0.8 2.2 -1.5 0.0 0.7 0.1 1.1
Family relationship satisfaction 3.3 4.1 10.1 -1.8 0.0 0.0 -2.7 -3.2
Leg pain on walking 0.0 0.1 0.2 0.1 0.0 -0.2 0.3 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.4 -0.9 0.0 -1.6 -0.5 -0.7
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.7 1.9 0.0 -1.5 -1.1 -1.2
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 7.2 1.0 0.0 2.1 1.0 2.7
Medication: Aspirin 0.3 0.4 1.3 1.2 0.0 0.4 0.4 0.3
Supplements: Vitamin C 0.1 0.2 0.5 -0.1 0.0 -0.1 -0.7 0.5
Knee pain experienced in last month 0.6 0.9 2.5 1.1 0.0 0.7 1.6 -0.4
Hypertension (Self-reported) 0.2 0.6 2.0 -0.9 0.0 -0.2 0.5 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.4 0.0 0.0 1.6 1.5 0.7
Illnesses of father: Heart disease 0.5 0.6 2.0 0.8 0.0 -0.4 -1.4 -0.7
Illnesses of siblings: Diabetes 1.6 2.0 5.7 0.3 0.0 -0.1 2.4 2.1
Smoking status: Previous 0.5 0.7 2.6 -0.4 0.0 0.8 -1.6 0.1
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 8.8 -2.4 0.0 1.0 -2.7 -3.0
Whole body fat-free mass 0.6 3.7 6.7 -1.8 0.0 2.6 -2.4 -1.7
Leg fat-free mass (right) 0.6 3.3 5.1 -1.5 0.0 2.3 -2.1 -2.2
Arm fat percentage (left) 1.0 4.2 17.1 -1.2 0.0 4.1 1.4 -0.6
Average weekly red wine intake 0.1 0.2 1.0 -0.1 0.0 0.1 -1.0 0.2
Handedness (chirality/laterality): Left-handed 0.8 0.9 3.1 0.3 0.0 0.6 1.8 1.0
Mood swings 0.2 0.4 1.5 -0.4 0.0 -0.6 0.1 -1.2
Loneliness, isolation 0.5 0.7 1.9 1.4 0.0 -0.9 0.2 -0.8
Long-standing illness, disability or infirmity 0.9 1.3 2.5 -1.5 0.0 1.3 -0.4 -1.6
Ever had bowel cancer screening 0.9 1.0 3.8 0.2 0.0 -0.1 1.1 1.9
Diabetes diagnosed by doctor 0.7 1.2 3.0 1.7 0.0 -1.1 1.2 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.9 0.9 0.0 -1.0 -0.9 -1.4
Friendships satisfaction 1.1 1.4 3.1 -0.0 0.0 -1.2 -1.5 -1.8
Qualifications: nursing, teaching 0.6 0.9 2.1 1.4 0.0 -1.3 0.7 -0.2
Commuting to job workplace: Walk 0.8 0.8 3.5 -1.9 0.0 0.7 0.3 -0.2
Eye problems/disorders: Cataract 0.6 0.7 1.9 -1.4 0.0 0.5 -1.2 0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.6 0.0 -0.6 0.7 -0.4
Medication for cholesterol 0.1 0.1 0.5 0.2 0.0 -0.1 -0.2 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 4.2 -0.7 0.0 0.4 -1.0 -2.0
Back pain experienced in last month 1.0 1.4 5.1 0.6 0.0 -1.2 0.1 -2.3
Mineral and other dietary supplements 0.6 0.8 1.5 1.2 0.0 -1.0 0.7 -0.9
Breast cancer (self-reported) 0.9 1.0 2.2 1.1 0.0 -1.0 1.5 1.0
Asthma (self-reported) 2.4 4.8 12.8 -3.6 0.0 2.9 -1.7 -0.1
Osteoporosis (self-reported) 0.5 0.6 1.5 -0.9 0.0 0.8 1.2 -0.4
Osteoarthritis (self-reported) 0.3 0.3 1.2 -0.0 0.0 0.5 1.1 0.3
Medication: Aspirin 0.2 0.3 1.1 1.1 0.0 0.5 0.3 0.0
Medication: Gliclazide 0.2 0.2 0.5 0.6 0.0 -0.1 -0.7 -0.3
Illnesses of father: None of the above (group 1) 1.1 1.3 4.8 -0.1 0.0 1.1 0.8 2.2
Smoking status: Current 0.5 0.8 2.1 0.5 0.0 1.2 1.5 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 7.1 -1.5 0.0 -1.2 -1.9 -2.7
Whole body water mass 0.7 3.9 6.5 -1.9 0.0 2.5 -2.5 -1.8
Leg predicted mass (right) 0.6 3.4 5.3 -1.5 0.0 2.3 -2.1 -2.3
Arm fat mass (left) 1.1 4.7 19.5 -1.6 0.0 4.4 0.4 -1.1
Number of self-reported non-cancer illnesses 0.5 0.9 2.7 -1.6 0.0 1.0 -0.1 -0.8
Average weekly champagne plus white wine intake 0.4 0.6 1.4 1.2 0.0 -0.9 0.7 0.3
Miserableness 0.2 0.4 1.8 0.2 0.0 0.5 0.1 -1.3
Guilty feelings 1.3 2.0 4.8 -2.2 0.0 1.7 -0.8 -1.3
Wears glasses or contact lenses 1.4 1.6 3.1 -1.7 0.0 1.4 0.3 1.7
Ever taken oral contraceptive pill 0.2 0.2 0.8 0.4 0.0 -0.9 -0.0 -0.0
Hearing aid user 0.9 1.1 3.3 -1.1 0.0 0.4 -0.9 -1.8
Mother’s age at death 0.4 0.5 1.4 0.9 0.0 1.2 -0.5 0.2
Financial situation satisfaction 2.3 2.8 10.7 -1.0 0.0 0.6 -1.4 -3.3
Tinnitus: Yes, now most or all of the time 1.3 1.5 4.8 -0.8 0.0 -0.1 -1.4 -2.2
Commuting to job workplace: Public transport 0.2 0.2 0.9 -0.9 0.0 0.3 0.1 -0.1
Eye problems/disorders: Glaucoma 1.6 1.9 4.2 -0.8 0.0 1.1 -1.8 -2.1
Medication: Blood pressure 0.2 0.3 1.0 -1.0 0.0 0.2 0.0 0.7
Pain type(s) experienced in last month: Hip pain 2.6 3.2 5.6 -2.2 0.0 1.3 -2.0 -2.4
Supplements: Fish oil (including cod liver oil) 1.3 1.7 3.5 -1.9 0.0 1.5 -1.1 1.2
High cholesterol (Self-reported) 1.0 1.7 4.3 -1.9 0.0 0.8 -2.1 -0.1
Medication: Bendroflumethiazide 0.0 0.0 0.1 -0.2 0.0 -0.2 -0.2 -0.1
Medication: Paracetamol 0.5 0.7 2.2 0.3 0.0 -1.0 0.7 -1.5
Medication: Lisinopril 0.9 1.2 2.7 1.6 0.0 -1.2 -0.3 1.2
Medication: Atorvastatin 0.6 0.8 3.6 -0.3 0.0 -0.3 -1.9 0.2
Illnesses of father: High blood pressure 0.8 1.1 2.0 -1.4 0.0 1.3 -0.1 -1.3
Alcohol drinker status: Never 0.3 0.4 1.4 0.5 0.0 -0.3 -0.2 -1.2
Ever smoked 0.2 0.3 0.8 0.4 0.0 0.9 0.5 0.6
Basal metabolic rate 0.7 4.1 9.5 -1.9 0.0 3.1 -2.0 -1.7
Leg fat percentage (left) 1.2 4.4 16.1 -0.9 0.0 4.0 2.1 0.7
Arm fat-free mass (left) 0.7 3.7 6.9 -2.1 0.0 2.6 -2.2 -1.5
Number of operations (self-reported) 0.7 1.0 3.4 1.2 0.0 0.1 1.9 0.1
Average weekly beer plus cider intake 0.2 0.2 0.4 0.7 0.0 -0.5 0.6 0.4
Irritability 0.4 0.7 1.6 -1.3 0.0 -0.3 -0.5 -1.1
Risk taking 1.0 1.5 3.5 1.2 0.0 -0.4 -1.5 -1.9
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 0.7 0.0 -0.5 0.7 -0.2
Fractured/broken bones in last 5 years 0.6 0.8 2.4 1.3 0.0 -0.2 1.5 0.2
Age started oral contraceptive pill 0.0 0.0 0.1 -0.1 0.0 0.2 -0.0 -0.4
Diastolic blood pressure, automated reading 0.7 2.2 9.0 -3.0 0.0 0.2 -1.3 -0.6
Ever depressed for a whole week 0.3 0.4 0.9 0.6 0.0 -1.0 0.2 -0.9
Unable to work because of sickness or disability 0.2 0.3 0.7 -0.8 0.0 0.6 0.5 0.4
Commuting to job workplace: Cycle 0.1 0.1 0.4 0.1 0.0 -0.3 0.6 0.2
Myopia 0.9 1.3 2.5 -1.6 0.0 1.2 1.5 0.7
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.7 0.7 0.0 0.6 0.1 -1.3
Cholesterol lowering medication 0.9 1.3 2.8 -1.6 0.0 0.4 -1.1 1.7
Medication: Omeprazole (e.g. Zanprol) 0.9 1.0 3.5 0.0 0.0 0.9 1.9 1.0
Pain experienced in last month 1.7 2.8 8.6 -0.4 0.0 2.3 0.3 2.9
Supplements: Calcium 1.0 1.2 3.8 -1.9 0.0 0.5 0.3 1.3
Basal cell carcinoma (self-reported) 2.8 3.3 7.2 -1.9 0.0 0.6 -2.7 -2.3
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.5 1.1 0.0 -1.9 -0.3 -0.4
Deep venous thrombosis (DVT) (self-reported) 2.5 3.2 9.7 1.4 0.0 -0.8 -2.0 -3.1
Heart disease (siblings) 0.3 0.4 0.6 0.7 0.0 -0.8 0.8 0.4
Alcohol drinker status: Previous 0.8 1.0 2.4 1.6 0.0 -0.4 0.7 -1.3
Pack years of smoking 0.0 0.1 0.3 0.1 0.0 -0.1 -0.5 0.3
Impedance of whole body 0.4 2.2 6.1 1.0 0.0 -1.9 2.5 0.6
Leg fat mass (left) 1.1 4.3 18.6 -1.3 0.0 4.3 1.1 -0.0
Arm predicted mass (left) 0.6 2.9 6.4 -1.7 0.0 2.5 -2.0 -1.3