TWAS hub - HOXB4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0946	0.0385	0.00110	0.014	NA	0.026	NA	0.030	3.1e-02	NA	0.00560	NA	0.00330
2	GTEx	Whole Blood	0.1380	0.0540	0.00290	-0.002	NA	-0.002	NA	-0.003	6.9e-01	NA	0.65000	NA	0.81000
3	YFS	Blood	0.0302	0.0111	0.00012	0.016	0.012	0.007	0.011	0.009	3.2e-06	7.3e-05	0.00160	8.6e-05	0.00041
4	TCGA	Breast Invasive Carcinoma	0.0406	0.0201	0.00072	0.005	0.015	0.016	NA	0.003	3.3e-02	3.7e-04	0.00026	NA	0.05800
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0330	0.0164	0.00300	0.005	0.025	0.016	NA	0.006	9.0e-02	7.0e-04	0.00530	NA	0.06500

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5
Ovarian Cancer	6.2	8.2	19.8	-2.7	0.5	-3.7	-4.5
Hand grip strength (right)	6.0	16.4	38.0	-6.2	2.7	-5.3	-2.9
Hand grip strength (left)	5.5	14.4	36.0	-6.0	2.5	-5.0	-2.2
Health satisfaction	4.0	5.1	12.0	-2.7	2.2	-1.2	-3.5
Body Mass Index (BMI) (2010)	3.4	4.7	13.7	-2.7	3.7	-1.5	-0.6
Mouth/teeth dental problems: Dentures	3.4	5.7	14.8	-2.3	2.5	-1.4	-3.8
Family relationship satisfaction	3.3	4.1	10.1	-1.8	0.0	-2.7	-3.2
Respiratory disease	3.2	7.0	18.8	-4.3	3.4	-2.0	-0.6
Blood Red Count	3.0	28.6	60.7	-6.7	2.9	-5.4	-7.8
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	6.9	2.5	-1.7	2.6	0.1
Asthma	2.8	5.4	14.5	-3.8	3.0	-1.8	-0.2
Basal cell carcinoma (self-reported)	2.8	3.3	7.2	-1.9	0.6	-2.7	-2.3
Blood clot in the leg (DVT)	2.7	3.4	10.6	1.1	-0.9	-2.1	-3.3
Pain type(s) experienced in last month: Hip pain	2.6	3.2	5.6	-2.2	1.3	-2.0	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.0	16.6	-2.5	-2.7	-4.1	-3.2
Pulse wave peak to peak time	2.5	3.0	10.2	-1.7	0.7	-3.2	-1.2
Chest pain or discomfort	2.5	3.7	8.7	-2.1	2.0	-1.0	-3.0
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	9.7	1.4	-0.8	-2.0	-3.1
Waist circumference	2.4	8.8	35.7	-2.7	6.0	0.4	-0.7
Pulse wave Arterial Stiffness index	2.4	2.7	9.5	1.8	-0.8	3.1	0.8
Medication: Ventolin 100micrograms inhaler	2.4	3.1	6.7	-2.3	2.6	-1.1	-1.4
Migraine (self-reported)	2.4	3.0	9.4	-1.4	-0.9	-1.6	-3.1
Overall health rating	2.4	5.1	13.9	-2.9	1.8	-0.4	-3.7
Asthma (self-reported)	2.4	4.8	12.8	-3.6	2.9	-1.7	-0.1
Financial situation satisfaction	2.3	2.8	10.7	-1.0	0.6	-1.4	-3.3
Ever used hormone-replacement therapy (HRT)	2.2	2.9	6.5	2.5	0.1	2.2	1.6
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	7.2	1.0	2.1	1.0	2.7
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	8.8	-2.4	1.0	-2.7	-3.0
Lung FEV1/FVC ratio	2.1	10.5	41.0	2.6	-6.4	1.4	1.8
Happiness	2.1	2.6	5.1	-1.9	-0.2	-2.1	-2.2
Glaucoma (self-reported)	2.1	2.5	6.9	-1.1	0.4	-2.0	-2.6
Worry too long after embarrassment	2.1	3.5	13.7	-0.9	-0.0	-1.8	-3.7
Type 2 Diabetes (T2D) (2012)	2.0	2.3	6.0	1.4	-1.3	1.4	2.4
Chronic bronchitis/emphysema (father)	2.0	2.4	5.8	2.4	-1.4	1.9	0.5
Forced vital capacity (FVC), Best measure	2.0	7.4	15.6	-2.8	-1.6	-4.0	-3.4
Systolic blood pressure, automated reading	1.9	5.6	24.6	0.4	-0.3	1.8	5.0
Had other major operations	1.9	2.3	4.8	-1.9	2.2	1.7	0.1
Forced expiratory volume in 1-second (FEV1)	1.9	6.3	14.9	-1.8	-2.5	-3.9	-2.6
Wheeze or whistling in the chest in last year	1.9	3.4	10.6	-2.2	3.2	-1.1	-0.7
Peak expiratory flow (PEF)	1.8	4.2	7.2	2.7	-2.2	1.9	2.3
Mouth/teeth dental problems: Loose teeth	1.8	2.2	4.0	1.6	-1.2	2.0	1.6
Pain experienced in last month	1.7	2.8	8.6	-0.4	2.3	0.3	2.9
Systolic Blood Pressure	1.6	7.9	26.7	1.2	-2.5	2.4	5.2
Relative age of first facial hair	1.6	3.2	6.2	2.5	-2.2	-2.0	-1.0
Tense / ‘highly strung’	1.6	2.6	6.0	-2.5	1.0	-1.4	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.6	-2.1	1.1	-1.9	-0.2
Illnesses of siblings: Diabetes	1.6	2.0	5.7	0.3	-0.1	2.4	2.1
Eye problems/disorders: Glaucoma	1.6	1.9	4.2	-0.8	1.1	-1.8	-2.1
Lung FVC	1.5	7.5	14.8	-2.4	-1.7	-3.9	-3.7
Hearing difficulty/problems: Yes	1.5	2.3	6.0	-2.4	0.4	0.3	-2.2
Medication for hormone replacement therapy	1.5	1.6	4.4	2.1	0.6	1.7	0.5
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.7	1.9	-1.5	-1.1	-1.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.8	1.1	-2.0	0.2	-1.5
Qualifications: CSEs or equivalent	1.4	1.8	4.3	0.2	-2.1	-1.3	-1.7
Medication: Levothyroxine sodium	1.4	2.4	6.6	-1.0	-1.2	-1.8	-2.6
Forced vital capacity (FVC)	1.4	5.4	13.0	-1.8	-1.5	-3.6	-2.9
Allergy	1.4	3.2	7.2	2.7	-0.8	1.8	2.2
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	8.2	-1.6	0.7	-0.7	-2.9
Exposure to tobacco smoke at home	1.4	1.6	2.7	1.5	-1.5	-0.9	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	7.1	-1.5	-1.2	-1.9	-2.7
Wears glasses or contact lenses	1.4	1.6	3.1	-1.7	1.4	0.3	1.7
Hair Pigment	1.3	38.3	79.9	8.3	-8.9	-5.9	-2.8
Townsend deprivation index at recruitment	1.3	1.9	6.2	-1.5	2.5	0.7	0.4
Financial difficulties in last 2 years	1.3	1.7	6.8	-0.8	0.1	-1.1	-2.6
Leg fat percentage (right)	1.3	4.7	18.9	-1.3	4.3	1.6	0.7
Guilty feelings	1.3	2.0	4.8	-2.2	1.7	-0.8	-1.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.8	-0.8	-0.1	-1.4	-2.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.5	-1.9	1.5	-1.1	1.2
Mean Putamen Volume	1.2	1.4	3.6	1.9	-0.3	1.7	0.5
Fasting Glucose	1.2	1.4	6.2	0.7	0.4	0.5	2.5
BMI	1.2	7.2	32.7	-1.2	5.7	1.1	-0.6
Sensitivity / hurt feelings	1.2	2.1	4.8	2.2	-2.0	0.7	-1.2
Pain all over the body in last month	1.2	1.3	4.4	-0.6	-0.9	-0.9	-2.1
Hip circumference	1.2	5.1	20.2	-2.1	4.5	0.3	-1.1
Pulse wave reflection index	1.2	1.5	4.1	1.6	-0.9	2.0	-0.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	6.0	-0.2	-2.5	-1.6	-1.8
Body fat percentage	1.2	4.6	18.0	-1.2	4.2	1.9	0.1
Exposure to tobacco smoke outside home	1.2	1.6	5.0	-0.9	-0.0	-1.5	-2.2
Medication: Omeprazole	1.2	1.5	3.3	-0.2	1.4	1.8	1.5
Leg fat mass (right)	1.2	4.7	20.4	-1.6	4.5	0.8	-0.0
Leg fat percentage (left)	1.2	4.4	16.1	-0.9	4.0	2.1	0.7
Coronary Artery Disease (CAD)	1.1	1.4	2.8	0.1	-1.2	-1.7	-1.6
Rheumatoid Arthritis	1.1	1.5	4.5	2.1	-1.4	0.6	0.5
Average weekly spirits intake	1.1	1.3	3.5	-0.7	0.2	-1.9	-1.6
Diabetes (father)	1.1	1.3	4.3	-0.0	-1.5	-0.4	-2.1
Trunk fat percentage	1.1	4.5	17.7	-1.6	4.2	1.5	-0.2
Serious illness, injury or assault to yourself	1.1	1.4	5.0	-1.1	0.0	0.8	-2.2
Trunk fat mass	1.1	4.7	19.3	-1.8	4.4	1.0	-0.4
Mouth/teeth dental problems	1.1	1.7	5.5	1.3	-0.6	0.9	2.3
Arm fat percentage (right)	1.1	4.5	18.5	-1.1	4.3	1.7	-0.1
Arm fat mass (right)	1.1	4.6	19.5	-1.6	4.4	0.5	-0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	4.5	0.4	-2.1	-0.9	-1.3
Medication: Paracetamol	1.1	1.9	4.1	1.3	-1.9	2.0	-0.1
Number of children fathered	1.1	1.3	2.3	-1.1	0.8	-1.5	-1.5
Friendships satisfaction	1.1	1.4	3.1	-0.0	-1.2	-1.5	-1.8
Illnesses of father: None of the above (group 1)	1.1	1.3	4.8	-0.1	1.1	0.8	2.2
Arm fat mass (left)	1.1	4.7	19.5	-1.6	4.4	0.4	-1.1
Leg fat mass (left)	1.1	4.3	18.6	-1.3	4.3	1.1	-0.0
Crohns Disease (2012)	1.0	1.7	3.1	-1.4	-0.3	-1.8	-1.8
Hypothyroidism (self reported)	1.0	2.2	7.1	0.1	-2.7	-1.1	-1.7
Body mass index (BMI)	1.0	4.3	18.9	-1.6	4.3	-0.0	-0.5
Medication: Simvastatin	1.0	1.5	4.3	-2.1	1.1	-1.0	0.8
Weight	1.0	4.9	18.8	-2.0	4.3	-0.5	-1.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.6	2.2	-1.0	0.3	-0.6
Headache pain in last month	1.0	1.8	6.8	-0.6	-1.3	0.2	-2.6
Birth weight	1.0	2.2	7.2	-2.7	1.3	-1.5	0.2
Whole body fat mass	1.0	4.3	18.2	-1.6	4.3	0.8	-0.4
Pulse rate, automated reading	1.0	3.1	7.2	-2.7	2.7	0.5	1.1
Arm fat percentage (left)	1.0	4.2	17.1	-1.2	4.1	1.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.2	-0.7	0.4	-1.0	-2.0
Back pain experienced in last month	1.0	1.4	5.1	0.6	-1.2	0.1	-2.3
High cholesterol (Self-reported)	1.0	1.7	4.3	-1.9	0.8	-2.1	-0.1
Risk taking	1.0	1.5	3.5	1.2	-0.4	-1.5	-1.9
Supplements: Calcium	1.0	1.2	3.8	-1.9	0.5	0.3	1.3
Age at First Birth	0.9	1.3	3.5	-0.0	0.5	1.9	1.7
HbA1C	0.9	1.0	2.4	1.6	-0.7	0.8	1.1
Ever had hysterectomy (womb removed)	0.9	1.1	4.1	0.9	0.1	2.0	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	4.2	-1.1	-0.6	-0.6	-2.0
Supplements: Glucosamine	0.9	1.2	2.9	0.2	1.1	1.7	1.3
Number of live births	0.9	1.3	5.2	-0.3	2.3	0.7	-0.7
Prospective memory result	0.9	1.1	2.5	0.6	0.9	1.6	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.5	-1.6	1.2	1.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.4	0.0	1.6	1.5	0.7
Long-standing illness, disability or infirmity	0.9	1.3	2.5	-1.5	1.3	-0.4	-1.6
Ever had bowel cancer screening	0.9	1.0	3.8	0.2	-0.1	1.1	1.9
Breast cancer (self-reported)	0.9	1.0	2.2	1.1	-1.0	1.5	1.0
Hearing aid user	0.9	1.1	3.3	-1.1	0.4	-0.9	-1.8
Medication: Lisinopril	0.9	1.2	2.7	1.6	-1.2	-0.3	1.2
Myopia	0.9	1.3	2.5	-1.6	1.2	1.5	0.7
Cholesterol lowering medication	0.9	1.3	2.8	-1.6	0.4	-1.1	1.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	3.5	0.0	0.9	1.9	1.0
Depressed Affect (Nagel 2018)	0.8	1.6	6.1	0.9	-0.9	-0.7	-2.5
Schizophrenia vs Biploar Disorder	0.8	1.0	3.9	-0.7	0.8	-0.4	-2.0
Crohns Disease (2017)	0.8	1.7	5.0	-2.2	0.4	-0.5	-1.8
Irritable Bowel Disease (IBD)	0.8	1.8	5.1	-1.8	0.7	-0.7	-2.2
Reaction Time	0.8	1.5	5.4	-0.5	-0.6	-2.3	-1.2
Waist Hip Ratio (WHR)	0.8	3.5	8.4	-2.7	2.9	-1.1	-0.8
Frequency of depressed mood in last 2 weeks	0.8	1.2	5.3	-0.3	-0.6	0.1	-2.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.2	-0.0	-0.7	-1.8	-1.2
Comparative body size at age 10	0.8	2.1	5.1	-0.6	2.3	-0.4	2.2
Emphysema/chronic bronchitis	0.8	0.9	2.5	-0.2	1.0	1.6	-1.0
Medication: Allopurinol	0.8	1.1	2.9	0.5	-0.2	1.5	1.7
Arm predicted mass (right)	0.8	4.3	6.1	-2.3	2.5	-2.4	-2.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.1	0.3	0.6	1.8	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.9	0.9	-1.0	-0.9	-1.4
Commuting to job workplace: Walk	0.8	0.8	3.5	-1.9	0.7	0.3	-0.2
Illnesses of father: High blood pressure	0.8	1.1	2.0	-1.4	1.3	-0.1	-1.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.5	1.1	-1.9	-0.3	-0.4
Alcohol drinker status: Previous	0.8	1.0	2.4	1.6	-0.4	0.7	-1.3
Depression (Nagel 2018)	0.7	1.0	4.4	-0.4	-0.8	0.0	-2.1
Ulcerative Colitis (UC)	0.7	1.3	5.4	-0.4	0.5	-0.7	-2.3
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.6	1.8	-0.2	1.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.6	-0.8	0.3	1.2	-1.6
Angina	0.7	0.9	2.2	0.9	-0.8	0.9	1.5
Leg fat-free mass (left)	0.7	3.7	7.4	-1.7	2.7	-2.0	-2.0
Fed-up feelings	0.7	1.3	6.4	0.2	-0.1	0.6	-2.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.9	-0.0	-2.0	-0.1	-0.4
Medication: Atenolol	0.7	0.9	1.8	-1.4	-0.5	-0.9	1.2
Leg predicted mass (left)	0.7	3.9	7.3	-1.8	2.7	-2.1	-2.1
Heart attack	0.7	0.9	2.8	1.1	-1.7	-0.3	-0.5
Diabetes (self-reported)	0.7	1.0	2.6	1.6	-1.2	1.0	-0.2
Illnesses of siblings	0.7	1.0	2.1	-0.7	0.8	-1.3	-1.4
Medication: Lansoprazole	0.7	0.8	1.9	1.0	-1.4	0.1	0.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	0.8	-0.3	1.4	-1.1
Arm fat-free mass (right)	0.7	3.4	5.1	-2.1	2.2	-2.2	-1.7
Medication: Ibuprofen	0.7	0.9	2.2	-1.2	-0.8	-0.2	-1.5
Mean time to correctly identify matches	0.7	1.3	5.3	-0.9	0.3	-2.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.4	-0.9	-1.6	-0.5	-0.7
Diabetes diagnosed by doctor	0.7	1.2	3.0	1.7	-1.1	1.2	-0.0
Whole body water mass	0.7	3.9	6.5	-1.9	2.5	-2.5	-1.8
Basal metabolic rate	0.7	4.1	9.5	-1.9	3.1	-2.0	-1.7
Arm fat-free mass (left)	0.7	3.7	6.9	-2.1	2.6	-2.2	-1.5
Number of operations (self-reported)	0.7	1.0	3.4	1.2	0.1	1.9	0.1
Diastolic blood pressure, automated reading	0.7	2.2	9.0	-3.0	0.2	-1.3	-0.6
Prostate Cancer	0.6	0.8	2.0	0.6	1.4	0.7	1.0
LDL Cholesterol	0.6	0.9	2.5	-1.6	1.0	-0.3	-1.0
Blood Platelet Count	0.6	6.4	19.2	-0.5	2.8	4.4	2.1
Neuroticism	0.6	1.4	4.1	-1.2	0.7	-0.9	-2.0
Supplements: Zinc	0.6	0.6	2.1	1.4	-0.9	0.3	-0.2
Medication: Co-codamol	0.6	0.6	1.9	0.9	-1.4	0.4	-0.5
Current tobacco smoking	0.6	1.0	2.5	0.2	1.4	1.6	-0.7
Maternal smoking around birth	0.6	0.9	2.9	1.7	-1.1	0.4	-0.6
Multivitamins +/- minerals	0.6	0.8	1.9	1.4	-1.0	0.8	0.7
High blood pressure (mother)	0.6	0.9	1.7	-1.3	-1.0	-0.8	-1.0
Medication: Ramipril	0.6	0.8	2.1	-1.5	1.3	0.2	0.1
Falls in the last year	0.6	0.7	1.3	1.0	0.4	1.0	-1.2
Noisy workplace	0.6	0.7	2.8	-1.7	0.0	-0.9	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.2	0.2	-1.8	0.6	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.7	-0.8	-1.3	-0.2	-1.2
Illnesses of mother	0.6	0.7	2.3	1.2	0.0	-0.0	1.5
Trunk predicted mass	0.6	3.2	6.2	-1.6	2.3	-2.5	-1.3
Medication: Amlodipine	0.6	0.8	2.1	-0.0	0.3	1.4	1.5
Eye problems/disorders: None of the above	0.6	0.7	1.5	1.2	-0.4	1.1	0.8
Medication: Blood pressure	0.6	1.1	3.1	0.1	0.8	1.4	1.8
Angina (self-reported)	0.6	0.7	1.8	0.8	-0.6	1.0	1.3
Heart disease (mother)	0.6	0.7	2.0	-0.8	-0.3	-0.9	-1.4
Knee pain experienced in last month	0.6	0.9	2.5	1.1	0.7	1.6	-0.4
Whole body fat-free mass	0.6	3.7	6.7	-1.8	2.6	-2.4	-1.7
Leg fat-free mass (right)	0.6	3.3	5.1	-1.5	2.3	-2.1	-2.2
Qualifications: nursing, teaching	0.6	0.9	2.1	1.4	-1.3	0.7	-0.2
Eye problems/disorders: Cataract	0.6	0.7	1.9	-1.4	0.5	-1.2	0.2
Mineral and other dietary supplements	0.6	0.8	1.5	1.2	-1.0	0.7	-0.9
Leg predicted mass (right)	0.6	3.4	5.3	-1.5	2.3	-2.1	-2.3
Medication: Atorvastatin	0.6	0.8	3.6	-0.3	-0.3	-1.9	0.2
Fractured/broken bones in last 5 years	0.6	0.8	2.4	1.3	-0.2	1.5	0.2
Arm predicted mass (left)	0.6	2.9	6.4	-1.7	2.5	-2.0	-1.3
Neuroticism (2016)	0.5	0.8	2.8	-0.0	-1.0	1.7	-0.2
Primary Biliary Cirrhosis	0.5	0.7	2.0	-1.4	0.3	0.0	-1.2
Allergy or Eczema	0.5	1.2	3.8	-0.3	-1.0	-1.1	-1.9
Chronotype (morning person)	0.5	1.1	3.9	-0.2	-1.2	-2.0	0.4
Tanning	0.5	6.4	18.2	-3.6	4.3	-0.1	0.9
Relative age voice broke	0.5	0.8	2.4	1.5	-0.9	0.2	-0.9
Taking other prescription medications	0.5	0.8	2.7	-0.5	0.9	1.6	-0.2
Age when periods started (menarche)	0.5	1.2	2.5	1.6	-1.1	1.5	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.6	-1.2	-0.2	-0.9	-1.6
Hearing difficulty/problems with background noise	0.5	0.7	2.6	-1.0	0.0	0.2	-1.6
Had menopause	0.5	0.6	1.1	0.5	1.0	0.9	0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	1.1	-1.3	-0.0	-0.3
Neuroticism score	0.5	1.1	4.1	-1.0	0.4	-0.3	-2.0
Impedance of arm (right)	0.5	2.2	7.5	1.2	-0.9	2.7	1.0
Trunk fat-free mass	0.5	3.1	6.1	-1.6	2.3	-2.5	-1.3
Time employed in main current job	0.5	0.6	2.3	-0.6	-0.3	-1.5	-0.7
Hair/balding pattern: Pattern 3	0.5	0.7	2.3	-1.5	-0.1	-0.8	0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.6	-0.1	-0.6	1.9	1.1
Breastfed as a baby	0.5	0.6	2.1	0.5	1.5	0.4	0.6
High blood pressure (siblings)	0.5	0.7	1.7	1.2	-1.3	-0.1	0.4
Neck or shoulder pain in last month	0.5	0.7	1.8	0.9	-1.4	0.4	-0.6
Had major operations	0.5	0.5	1.2	1.1	-0.7	0.4	-0.9
Age at last live birth	0.5	0.8	2.2	-1.5	0.7	0.1	1.1
Illnesses of father: Heart disease	0.5	0.6	2.0	0.8	-0.4	-1.4	-0.7
Smoking status: Previous	0.5	0.7	2.6	-0.4	0.8	-1.6	0.1
Loneliness, isolation	0.5	0.7	1.9	1.4	-0.9	0.2	-0.8
Osteoporosis (self-reported)	0.5	0.6	1.5	-0.9	0.8	1.2	-0.4
Smoking status: Current	0.5	0.8	2.1	0.5	1.2	1.5	-0.5
Number of self-reported non-cancer illnesses	0.5	0.9	2.7	-1.6	1.0	-0.1	-0.8
Medication: Paracetamol	0.5	0.7	2.2	0.3	-1.0	0.7	-1.5
Neuroticism (Nagel 2018)	0.4	1.0	3.7	-0.0	-0.8	-0.8	-1.9
Worry (Nagel 2018)	0.4	0.8	1.6	-1.3	0.4	-1.1	-1.0
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	0.9	0.6	1.0	-0.6
Bipolar Disorder (2011)	0.4	0.4	1.8	-0.5	-1.3	0.0	0.2
Medication: Metformin	0.4	0.6	1.1	1.1	0.1	0.9	0.9
Diabetes (mother)	0.4	0.5	1.3	1.0	-1.1	0.1	-0.5
Average weekly fortified wine intake	0.4	0.5	1.1	-1.1	0.2	-0.9	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	0.6	1.1	-0.5	-0.3
High blood pressure	0.4	1.1	4.1	-1.0	-0.2	0.5	2.0
Stomach or abdominal pain in last month	0.4	0.5	1.7	-0.3	-0.7	-0.3	-1.3
Impedance of leg (left)	0.4	2.1	5.4	0.9	-1.5	2.3	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.3	-0.9	0.5	0.4	-1.5
Lung cancer (father)	0.4	0.5	1.8	0.2	-1.4	0.7	-0.4
Length of working week for main job	0.4	0.5	1.0	-0.9	-0.3	-0.8	-1.0
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	-0.7	1.5	1.1	0.9
Number of full brothers	0.4	0.5	2.0	0.0	-0.6	0.4	-1.4
Medication: Seretide 50 evohaler	0.4	0.4	1.2	-0.8	0.5	0.4	-1.1
Comparative height size at age 10	0.4	2.0	5.5	-2.4	1.2	-1.4	-1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.4	1.2	-0.9	0.7	0.3
Mother’s age at death	0.4	0.5	1.4	0.9	1.2	-0.5	0.2
Irritability	0.4	0.7	1.6	-1.3	-0.3	-0.5	-1.1
Impedance of whole body	0.4	2.2	6.1	1.0	-1.9	2.5	0.6
Bipolar Disorder (2018)	0.3	0.5	1.1	0.4	-0.6	0.8	1.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	-1.3	0.5	-0.7	1.4
Alzheimer’s Disease (in father)	0.3	0.3	1.1	-0.4	-0.4	-0.2	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.5	1.6	0.2	1.0	0.0	-1.3
Major Depression (MDD)	0.3	0.3	1.0	-0.3	-1.0	0.2	-0.7
Lupus	0.3	0.5	2.1	0.3	0.5	0.2	1.5
Blood Eosinophil Count	0.3	2.6	4.7	0.5	2.1	2.2	1.8
Blood White Count	0.3	2.6	5.1	1.9	1.9	2.3	0.5
Impedance of leg (right)	0.3	1.4	3.4	0.4	-1.2	1.8	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.3	0.3	0.2	-1.8	-0.2
Alcohol usually taken with meals	0.3	0.5	2.0	0.4	0.1	0.5	1.4
Alcohol intake versus 10 years previously	0.3	0.4	1.0	-0.4	1.0	0.4	0.9
Father’s age at death	0.3	0.4	1.1	-0.8	-1.1	0.1	-0.0
Worrier / anxious feelings	0.3	0.6	1.5	-1.2	0.9	-0.4	-0.7
Pulse rate	0.3	0.5	0.9	-0.8	0.9	-0.4	-0.9
Depression (self-reported)	0.3	0.4	1.4	-1.2	-0.6	-0.3	-0.5
Impedance of arm (left)	0.3	1.5	4.8	1.0	-1.2	2.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.3	-0.8	0.8	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.5	1.2	0.3	0.2	0.1
Shortness of breath walking on level ground	0.3	0.4	1.9	-0.2	0.0	0.2	-1.4
Medication for pain relief, constipation, heartburn	0.3	0.6	2.7	0.2	0.4	-0.3	1.6
Alcohol intake frequency.	0.3	0.6	1.9	0.8	1.4	0.7	0.2
Number of full sisters	0.3	0.4	0.9	-0.6	0.4	-1.0	-0.7
Suffer from ‘nerves’	0.3	0.4	1.4	1.2	-0.8	0.2	-0.1
Medication: Aspirin	0.3	0.4	1.3	1.2	0.4	0.4	0.3
Osteoarthritis (self-reported)	0.3	0.3	1.2	-0.0	0.5	1.1	0.3
Alcohol drinker status: Never	0.3	0.4	1.4	0.5	-0.3	-0.2	-1.2
Ever depressed for a whole week	0.3	0.4	0.9	0.6	-1.0	0.2	-0.9
Heart disease (siblings)	0.3	0.4	0.6	0.7	-0.8	0.8	0.4
Breast Cancer	0.2	0.4	1.4	0.4	1.2	0.6	0.3
Triglycerides	0.2	0.4	0.9	-0.1	-0.9	0.4	-1.0
Ulcerative Colitis	0.2	0.3	1.0	0.0	0.4	-0.6	-1.0
Smoking Status	0.2	0.6	1.0	0.8	1.0	0.7	-0.8
Cardiovascular Disease	0.2	0.8	1.8	-1.3	0.2	-0.8	1.2
Vitamin and mineral supplements	0.2	0.3	0.9	0.1	1.0	0.7	0.3
Past tobacco smoking	0.2	0.4	1.6	-0.3	-1.3	0.5	-0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	0.2	0.9	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.8	0.6	0.2	-1.3	-0.4
Fluid intelligence score	0.2	0.4	1.0	1.0	-0.4	0.8	-0.1
Medication: Cholesterol lowering	0.2	0.3	1.0	-0.5	0.4	-1.0	0.4
Standing height	0.2	1.7	3.8	-1.5	0.5	-1.6	-1.9
Birth weight of first child	0.2	0.3	1.3	0.1	0.0	0.5	1.1
Loud music exposure frequency	0.2	0.2	0.8	0.9	0.0	-0.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.8	-1.3	-0.2	-0.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.4	0.1	-0.5	-0.3	-1.2
Gout (self-reported)	0.2	0.3	1.2	-0.4	-0.5	0.3	1.1
Age at first live birth	0.2	0.4	1.1	-0.9	0.4	-0.2	1.0
Qualifications: College or University degree	0.2	0.6	1.7	0.3	-1.1	0.3	1.3
Hypertension (Self-reported)	0.2	0.6	2.0	-0.9	-0.2	0.5	1.4
Mood swings	0.2	0.4	1.5	-0.4	-0.6	0.1	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.6	-0.6	0.7	-0.4
Medication: Aspirin	0.2	0.3	1.1	1.1	0.5	0.3	0.0
Medication: Gliclazide	0.2	0.2	0.5	0.6	-0.1	-0.7	-0.3
Miserableness	0.2	0.4	1.8	0.2	0.5	0.1	-1.3
Ever taken oral contraceptive pill	0.2	0.2	0.8	0.4	-0.9	-0.0	-0.0
Commuting to job workplace: Public transport	0.2	0.2	0.9	-0.9	0.3	0.1	-0.1
Medication: Blood pressure	0.2	0.3	1.0	-1.0	0.2	0.0	0.7
Ever smoked	0.2	0.3	0.8	0.4	0.9	0.5	0.6
Average weekly beer plus cider intake	0.2	0.2	0.4	0.7	-0.5	0.6	0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.7	-0.5	0.7	-0.2
Unable to work because of sickness or disability	0.2	0.3	0.7	-0.8	0.6	0.5	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.7	0.7	0.6	0.1	-1.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.5	-0.3	0.8	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	-0.3	-1.0	-0.2	0.7
Schizophrenia (2014)	0.1	0.3	0.9	0.8	-0.1	0.2	-1.0
Heel T-Score	0.1	0.7	1.8	1.3	0.2	0.3	1.4
Height	0.1	1.6	2.9	-0.9	1.5	-1.7	-1.5
Number of treatments/medications taken	0.1	0.1	0.5	-0.7	-0.2	-0.2	-0.1
Severe depression (siblings)	0.1	0.1	0.3	0.5	-0.3	0.6	0.1
Sitting height	0.1	0.9	1.5	-1.2	-0.8	-1.2	-0.9
Number of incorrect matches in round	0.1	0.2	0.7	-0.8	-0.6	-0.1	-0.1
Nervous feelings	0.1	0.3	0.9	-1.0	0.3	0.1	0.5
Qualifications: None of the above	0.1	0.3	0.8	0.6	0.9	-0.1	0.4
Supplements: Vitamin C	0.1	0.2	0.5	-0.1	-0.1	-0.7	0.5
Average weekly red wine intake	0.1	0.2	1.0	-0.1	0.1	-1.0	0.2
Medication for cholesterol	0.1	0.1	0.5	0.2	-0.1	-0.2	-0.7
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.1	-0.3	0.6	0.2
Schizophrenia (2018)	0.0	0.1	0.3	0.1	0.1	0.4	-0.6
HDL Cholesterol	0.0	0.1	0.3	0.2	0.1	-0.5	-0.1
Pack years adult smoking proportion	0.0	0.0	0.1	-0.3	0.0	-0.2	0.3
Leg pain on walking	0.0	0.1	0.2	0.1	-0.2	0.3	-0.4
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.1
Age started oral contraceptive pill	0.0	0.0	0.1	-0.1	0.2	-0.0	-0.4
Pack years of smoking	0.0	0.1	0.3	0.1	-0.1	-0.5	0.3

Hub : Genes

HOXB4

Models

Trait associations