[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr19:45,286,263-50,460,914

Best TWAS P=1.73e-37 · Best GWAS P=9.65e-36 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	CCDC9	0.19	0.10	enet	11	0.11	3.1e-06	-4.8	5.2	1.9e-07	0.02	0.20	0.77	TRUE
2	GTEx	Adipose Visceral Omentum	DMWD	0.11	0.13	lasso	2	0.16	7.3e-09	-8.5	-11.5	9.1e-31	-0.89	0.01	0.99	FALSE
3	GTEx	Artery Aorta	DMWD	0.28	0.19	lasso	3	0.15	1.2e-08	12.5	-12.2	3.9e-34	-0.99	0.00	1.00	FALSE
4	GTEx	Artery Tibial	DMPK	0.12	0.03	lasso	4	0.03	3.1e-03	-2.7	-8.3	1.2e-16	-0.70	0.03	0.95	TRUE
5	GTEx	Artery Tibial	DMWD	0.22	0.17	lasso	8	0.16	6.8e-13	12.5	-12.5	9.0e-36	-0.99	0.00	1.00	FALSE
6	GTEx	Artery Tibial	AC074212.6	0.14	0.04	lasso	5	0.06	2.4e-05	12.1	-10.7	7.6e-27	-0.85	0.01	0.99	FALSE
7	GTEx	Brain Putamen basal ganglia	PNMAL1	0.28	0.00	lasso	5	0.03	5.8e-02	5.3	5.7	1.0e-08	-0.01	0.01	0.81	TRUE
8	GTEx	Cells Transformed fibroblasts	DMPK	0.10	0.07	lasso	6	0.07	1.0e-05	-5.8	-5.2	2.1e-07	-0.45	0.87	0.04	FALSE
9	GTEx	Cells Transformed fibroblasts	RASIP1	0.19	0.14	lasso	6	0.20	6.1e-15	-6.8	-6.3	3.5e-10	0.04	0.00	1.00	FALSE
10	GTEx	Cells Transformed fibroblasts	SYMPK	0.18	0.14	lasso	6	0.13	7.5e-10	-5.4	7.0	2.2e-12	0.37	1.00	0.00	FALSE
11	GTEx	Heart Atrial Appendage	NUCB1-AS1	0.16	0.04	lasso	3	0.07	5.3e-04	6.1	5.4	5.2e-08	-0.05	0.03	0.64	FALSE
12	GTEx	Lung	DMPK	0.10	0.05	lasso	3	0.05	5.4e-05	-8.6	-10.4	3.1e-25	-0.77	0.04	0.95	FALSE
13	GTEx	Muscle Skeletal	DMWD	0.06	0.01	lasso	6	0.01	1.9e-02	12.5	-12.8	1.7e-37	-0.96	0.00	0.98	TRUE
14	GTEx	Nerve Tibial	FOSB	0.28	0.00	lasso	4	0.00	4.1e-01	-4.8	-5.6	2.5e-08	-0.19	0.99	0.00	FALSE
15	GTEx	Nerve Tibial	DMWD	0.24	0.07	lasso	6	0.06	5.8e-05	12.5	-10.2	1.6e-24	-0.91	0.00	1.00	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	NTN5	0.19	0.07	lasso	5	0.08	2.5e-05	-6.5	-6.1	1.4e-09	0.04	0.02	0.98	FALSE
17	GTEx	Skin Sun Exposed Lower leg	QPCTL	0.08	0.00	lasso	4	0.00	2.1e-01	8.7	-9.7	3.7e-22	-0.65	0.02	0.83	FALSE
18	GTEx	Skin Sun Exposed Lower leg	DMPK	0.13	0.08	lasso	3	0.07	2.5e-06	-8.5	-8.6	1.3e-17	-0.62	0.86	0.13	FALSE
19	GTEx	Skin Sun Exposed Lower leg	NTN5	0.11	0.09	enet	18	0.05	6.2e-05	-6.8	-5.9	4.6e-09	0.04	0.00	1.00	FALSE
20	GTEx	Skin Sun Exposed Lower leg	DMWD	0.10	0.07	lasso	4	0.07	4.1e-06	-8.5	-8.1	4.4e-16	-0.60	0.16	0.81	FALSE
21	GTEx	Skin Sun Exposed Lower leg	AC074212.6	0.13	0.08	enet	27	0.08	7.2e-07	-8.5	-8.9	8.3e-19	-0.56	0.15	0.85	FALSE
22	GTEx	Testis	SYMPK	0.22	0.21	lasso	1	0.20	2.9e-09	-5.6	-5.7	1.6e-08	-0.25	0.97	0.00	FALSE
23	GTEx	Testis	DMWD	0.19	0.15	lasso	3	0.13	2.7e-06	-8.5	-8.5	2.4e-17	-0.62	0.50	0.37	FALSE
24	GTEx	Thyroid	DMPK	0.13	0.11	lasso	2	0.12	1.3e-09	-8.4	-10.6	1.9e-26	-0.81	0.04	0.96	FALSE
25	GTEx	Thyroid	DMWD	0.11	0.12	lasso	3	0.11	6.7e-09	-8.6	-11.2	2.9e-29	-0.85	0.01	0.99	FALSE
26	GTEx	Thyroid	AC074212.6	0.08	0.10	lasso	2	0.09	1.8e-07	12.5	-12.5	8.0e-36	-1.00	0.00	1.00	FALSE
27	GTEx	Whole Blood	DMPK	0.07	0.04	lasso	5	0.02	2.2e-03	-8.6	-8.4	3.5e-17	-0.56	0.19	0.66	FALSE
28	GTEx	Whole Blood	AC074212.6	0.07	0.04	lasso	3	0.02	4.2e-03	-8.6	-8.9	3.9e-19	-0.58	0.14	0.74	FALSE
29	METSIM	Adipose	SYMPK	0.05	0.03	lasso	3	0.01	2.9e-03	-5.6	5.8	6.7e-09	0.34	0.64	0.34	TRUE
30	YFS	Blood	DMWD	0.06	0.04	enet	19	0.05	3.8e-15	-8.5	-6.3	2.6e-10	-0.46	1.00	0.00	FALSE
31	YFS	Blood	PTGIR	0.05	0.03	bslmm	345	0.03	5.2e-10	5.3	-5.7	1.5e-08	-0.07	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FUT2	0.05	0.01	blup	52	0.01	6.1e-02	-4.7	5.3	1.4e-07	-0.03	0.03	0.33	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	DMWD	0.01	0.00	blup	42	0.01	7.3e-03	-5.6	11.2	3.8e-29	0.85	0.02	0.63	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	FOXA3	0.03	0.02	blup	53	0.02	1.9e-04	12.2	-6.9	5.2e-12	-0.74	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	FUT2	0.03	0.05	blup	54	0.05	1.9e-10	-6.8	5.9	3.1e-09	-0.05	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	NTN5	0.02	0.01	enet	11	0.01	7.6e-04	-6.2	-6.2	7.5e-10	0.01	0.01	0.91	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	RASIP1	0.02	0.02	blup	56	0.03	3.8e-07	-6.3	-6.0	2.4e-09	0.03	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FUT2	0.10	0.02	blup	55	0.06	6.8e-04	-6.2	6.1	8.1e-10	-0.03	0.01	0.98	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	FUT2	0.18	0.22	enet	12	0.18	6.8e-11	-6.5	6.7	2.5e-11	-0.05	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	SEC1	0.05	0.04	enet	11	0.01	8.5e-02	-6.6	6.0	2.1e-09	-0.04	0.02	0.85	FALSE
41	The Cancer Genome Atlas	Esophageal Carcinoma	FUT2	0.33	0.27	lasso	3	0.24	3.9e-08	6.1	6.3	3.9e-10	-0.04	0.02	0.97	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FUT2	0.11	0.22	blup	52	0.22	6.3e-24	-6.8	6.2	4.7e-10	-0.04	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYMPK	0.07	0.04	lasso	2	0.03	9.4e-05	-5.4	6.0	1.7e-09	0.26	0.55	0.11	TRUE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FUT2	0.10	0.01	blup	51	0.05	9.8e-04	-6.6	5.6	2.6e-08	-0.06	0.02	0.89	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SIX5	0.05	0.05	lasso	8	0.03	7.6e-03	12.2	12.3	1.3e-34	0.96	0.01	0.90	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	CPT1C	0.06	0.00	blup	34	0.00	9.2e-02	1.3	-5.2	1.6e-07	0.07	0.00	0.00	TRUE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	NTN5	0.05	0.04	lasso	2	0.02	6.7e-04	-6.3	-6.3	3.1e-10	0.05	0.01	0.98	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	FUT2	0.09	0.12	blup	52	0.12	4.2e-14	-6.2	6.2	6.3e-10	-0.04	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FUT2	0.05	0.08	lasso	2	0.08	6.7e-09	-6.6	6.6	3.3e-11	-0.05	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FUT2	0.06	0.00	blup	53	0.05	3.5e-04	-4.7	6.0	2.4e-09	-0.04	0.02	0.84	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FUT2	0.08	0.12	lasso	4	0.11	2.5e-05	-6.8	6.8	9.4e-12	-0.05	0.01	0.98	TRUE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	FUT2	0.05	0.06	blup	52	0.06	8.6e-07	-6.8	6.3	2.7e-10	-0.04	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYMPK	0.09	0.06	lasso	3	0.05	8.7e-06	-5.6	5.9	4.3e-09	0.28	0.97	0.00	FALSE
54	The Cancer Genome Atlas	Rectum Adenocarcinoma	FUT2	0.26	0.28	lasso	10	0.22	5.2e-06	-6.3	6.1	1.0e-09	-0.05	0.02	0.97	FALSE
55	The Cancer Genome Atlas	Soft Tissue Sarcoma	RASIP1	0.05	0.06	blup	54	0.04	1.4e-03	6.1	-5.3	8.8e-08	0.02	0.03	0.65	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	FUT2	0.14	0.16	lasso	8	0.14	4.9e-10	-6.8	6.7	2.3e-11	-0.05	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	FUT2	0.06	0.04	blup	54	0.06	1.1e-06	6.1	5.8	8.9e-09	-0.03	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	NTN5	0.11	0.07	blup	43	0.09	2.6e-09	-6.2	-6.1	9.2e-10	0.06	0.04	0.96	FALSE