Hub : Genes

SYMPK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0840 0.0250 2.9e-05 0.043 0.034 0.043 0.040 0.042 5.8e-06 5.1e-05 5.7e-06 1.2e-05 6.5e-06
2 GTEx Cells Transformed fibroblasts 0.1770 0.0450 6.9e-06 0.140 NA 0.099 NA 0.128 1.2e-10 NA 7.5e-08 NA 7.5e-10
3 GTEx Nerve Tibial 0.1498 0.0476 8.9e-04 0.049 NA 0.083 NA 0.075 2.2e-04 NA 1.8e-06 NA 5.4e-06
4 GTEx Testis 0.2200 0.0740 2.5e-03 0.210 NA 0.179 NA 0.200 1.1e-09 NA 2.3e-08 NA 2.9e-09
5 METSIM Adipose 0.0476 0.0169 6.7e-04 0.026 0.007 0.007 0.009 0.014 8.1e-05 2.3e-02 2.6e-02 1.3e-02 2.9e-03
6 YFS Blood 0.0663 0.0150 9.8e-10 0.012 0.031 0.027 0.032 0.028 7.3e-05 1.7e-10 2.0e-09 1.2e-10 1.2e-09
7 TCGA Breast Invasive Carcinoma 0.0283 0.0142 2.9e-03 0.020 0.010 0.017 NA 0.021 4.0e-05 2.8e-03 1.5e-04 NA 3.5e-05
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0719 0.0334 1.1e-03 0.043 0.012 0.020 NA 0.034 1.2e-05 1.6e-02 2.3e-03 NA 9.4e-05
9 TCGA Prostate Adenocarcinoma 0.0870 0.0366 2.0e-05 0.063 0.034 0.044 NA 0.048 3.3e-07 1.5e-04 1.8e-05 NA 8.7e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.2 0.2 1.1 0.7 -0.3 -0.4 0.1 0.4 -0.1 1.1 -0.3 -0.0
Bipolar Disorder or Schizophrenia 0.2 0.6 2.0 0.2 -0.6 -1.2 0.5 -0.2 -0.0 1.4 -0.9 -0.4
Depressed Affect (Nagel 2018) 0.3 0.6 2.6 -0.6 -0.6 -0.7 0.7 -0.7 1.6 0.1 -0.5 -0.6
Depression (Nagel 2018) 1.2 1.8 3.6 1.9 1.2 1.4 -1.3 1.8 0.7 0.5 1.3 1.4
Intelligence (Savage-Jansen 2018) 0.8 2.4 6.6 0.7 1.8 0.5 -1.8 1.4 -2.6 0.9 1.5 1.8
Neuroticism (Nagel 2018) 0.2 0.4 3.7 -0.1 0.1 -0.2 -0.1 -0.0 1.9 -0.1 0.0 0.2
Schizophrenia (2018) 0.2 0.5 1.7 -0.3 -0.5 -1.3 0.5 -0.5 0.1 1.0 -1.0 -0.4
Schizophrenia vs Biploar Disorder 0.4 0.5 1.5 0.8 0.1 1.2 0.2 0.1 -1.0 1.1 -0.1 -0.1
Worry (Nagel 2018) 0.2 0.4 3.5 0.1 -0.1 -0.3 0.0 -0.1 1.9 -0.3 -0.3 0.0
Alzheimer’s Disease (in mother) 0.4 0.4 1.9 0.2 -0.3 -0.6 0.6 0.0 1.4 -0.7 0.0 -0.6
Alzheimer’s Disease (in father) 0.6 0.6 2.1 0.1 -1.1 0.3 1.0 -0.1 1.4 -0.0 -0.7 -0.9
Alzheimer’s Disease (including proxy) 1.1 1.6 5.9 0.9 -1.5 0.1 1.5 -0.2 2.4 0.0 -0.8 -1.4
Crohns Disease (2017) 0.4 0.9 6.4 -0.6 0.3 -2.5 0.1 -0.1 0.8 -0.5 -0.1 -0.2
Irritable Bowel Disease (IBD) 0.3 0.6 3.5 -0.6 1.0 -1.9 -0.4 0.1 0.4 -0.1 0.6 0.3
Ulcerative Colitis (UC) 0.1 0.3 0.9 -0.1 0.9 -0.2 -0.6 0.2 0.2 0.3 0.7 0.6
Major Depression (MDD) 1.9 2.3 6.3 -0.5 -1.6 -0.5 1.9 -1.2 2.5 -0.6 -1.8 -1.7
Reaction Time 2.0 3.8 7.1 -2.1 -1.8 -2.7 2.0 -2.2 0.6 -1.1 -2.3 -2.0
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.6 0.1 1.3 0.1 -1.4 0.8 -1.6 -0.1 0.9 1.3
Breast Cancer 0.6 1.4 2.1 0.8 1.4 1.1 -1.4 1.0 -1.1 0.7 1.4 1.4
Ovarian Cancer 0.7 0.9 2.8 1.7 0.5 1.7 -0.3 1.2 -0.1 -0.2 0.6 0.4
Prostate Cancer 1.2 1.7 3.3 1.2 1.4 1.6 -1.2 1.2 -0.7 1.0 1.8 1.2
Age at First Birth 0.1 0.2 0.6 -0.4 -0.3 -0.8 0.3 -0.3 0.3 -0.1 -0.6 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.4 1.9 3.8 0.4 1.4 1.0 -1.6 1.2 -1.9 1.5 1.6 1.5
Coronary Artery Disease (CAD) 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.5 0.3
Crohns Disease (2012) 0.2 0.3 1.4 -0.5 0.4 -1.2 0.3 0.1 0.8 -0.2 0.0 -0.3
Mean Putamen Volume 0.7 0.8 1.4 -0.4 -1.2 -0.1 1.2 -1.1 1.0 0.1 -1.0 -1.1
Fasting Glucose 0.1 0.2 0.7 -0.5 0.4 -0.8 0.0 -0.5 -0.4 0.2 -0.1 -0.0
HbA1C 1.7 1.9 3.5 -1.9 -1.2 -1.7 1.5 -1.4 0.4 -1.0 -1.4 -1.5
HDL Cholesterol 1.7 2.9 5.4 1.3 2.1 1.2 -2.1 1.9 -0.6 0.1 2.3 2.1
LDL Cholesterol 0.5 0.8 4.9 0.8 -0.3 0.4 0.1 0.6 1.1 -2.2 0.1 -0.1
Lupus 0.8 1.2 2.2 -0.9 -1.3 -1.5 1.3 -0.9 0.2 0.5 -1.2 -1.3
Neuroticism (2016) 1.5 2.2 3.7 1.9 1.5 1.6 -1.0 1.3 1.2 1.8 1.5 1.2
Primary Biliary Cirrhosis 3.4 4.8 8.6 1.8 2.7 1.6 -2.5 2.3 -1.6 1.1 2.9 2.5
Rheumatoid Arthritis 0.2 0.3 0.9 -0.6 0.5 -0.9 -0.4 0.1 -0.8 -0.4 0.4 0.3
Schizophrenia (2014) 0.3 0.7 1.8 -0.1 -0.9 -0.9 0.9 -0.6 0.5 0.8 -1.4 -0.8
Triglycerides 2.6 4.2 6.6 -2.1 -2.4 -2.3 2.3 -2.0 0.0 -1.1 -2.6 -2.4
Type 2 Diabetes (T2D) (2012) 1.6 1.8 7.5 0.0 0.0 0.0 0.0 0.0 0.0 -1.6 -2.7 -2.5
Ulcerative Colitis 0.9 1.4 3.6 -1.9 -0.5 -1.8 1.0 -1.3 0.4 -0.8 -0.7 -1.1
Blood Eosinophil Count 12.5 96.2 139.2 10.6 11.8 8.5 -10.5 11.5 -5.3 6.1 10.8 10.8
Blood Platelet Count 1.3 15.4 24.3 2.2 3.4 4.8 -4.9 3.2 -3.2 3.0 4.8 4.6
Blood Red Count 2.9 27.7 33.9 -4.9 -4.9 -5.3 5.8 -5.7 4.0 -5.5 -5.4 -5.7
Blood White Count 0.4 2.9 6.2 0.9 2.5 0.4 -2.2 1.7 -0.3 1.5 2.1 2.1
Heel T-Score 0.1 0.6 2.3 0.0 -0.1 1.5 -1.0 0.4 -1.0 0.2 0.8 0.8
BMI 1.0 5.5 13.5 -0.6 3.3 -0.2 -3.1 1.4 -2.1 1.0 3.7 2.8
Height 0.0 0.8 3.5 0.4 -1.9 1.2 0.4 -0.5 0.5 -0.5 -1.1 -0.5
Waist Hip Ratio (WHR) 0.3 1.5 4.8 0.4 2.2 -0.7 -1.5 1.1 0.3 0.7 1.4 1.5
Systolic Blood Pressure 1.7 8.5 14.9 -3.9 -3.5 -3.1 3.0 -3.3 -0.1 -1.1 -2.8 -3.3
Smoking Status 0.4 1.1 2.2 -0.9 -1.0 -1.1 1.1 -0.7 1.5 0.8 -0.8 -1.1
Allergy or Eczema 0.2 0.5 2.6 -0.3 0.6 0.1 -0.5 0.1 -1.6 -1.0 0.7 0.4
Cardiovascular Disease 0.4 1.2 2.6 -1.2 0.6 -1.6 -0.9 0.2 -1.4 -1.4 0.9 0.6
Hypothyroidism (self reported) 0.1 0.3 1.3 -0.7 0.1 0.1 0.2 -0.6 0.5 1.1 0.2 -0.2
Respiratory disease 4.1 9.1 13.9 -3.1 -3.7 -2.2 3.2 -3.6 0.7 -2.6 -3.4 -3.3
Type 2 Diabetes (T2D) (2018) 1.4 2.6 6.9 -0.8 -0.9 -2.5 1.4 -0.7 1.5 -2.6 -1.4 -1.4
Lung FEV1/FVC ratio 4.8 24.4 49.3 4.4 7.0 2.5 -5.7 5.8 -1.4 2.6 6.0 5.9
Lung FVC 0.7 3.4 7.8 0.8 -2.3 1.1 2.2 -1.0 2.8 -0.9 -2.1 -1.9
Neuroticism 0.1 0.2 1.7 -0.3 -0.1 -0.3 0.1 -0.2 1.3 0.1 -0.2 -0.1
Chronotype (morning person) 0.2 0.5 2.0 0.6 -1.1 0.5 0.4 -0.2 0.5 -1.4 -0.7 -0.4
Hair Pigment 0.1 3.6 9.6 -3.1 -1.8 -2.1 1.3 -2.6 0.6 -1.1 -1.6 -1.6
Tanning 0.3 4.0 5.5 -2.1 -2.0 -1.8 2.1 -2.4 1.8 -1.8 -1.8 -2.2
Hand grip strength (left) 1.7 4.4 8.4 2.4 1.9 2.9 -2.1 2.4 -0.4 1.5 2.3 2.1
Number of treatments/medications taken 0.1 0.1 0.7 -0.1 0.4 0.2 -0.2 0.2 -0.8 0.5 0.2 0.2
Average weekly spirits intake 0.1 0.1 0.5 -0.2 0.0 -0.1 0.7 -0.1 -0.1 -0.4 -0.1 -0.7
Sensitivity / hurt feelings 0.1 0.2 0.9 -0.5 0.1 0.5 -0.3 -0.2 0.9 0.3 -0.0 0.2
Frequency of depressed mood in last 2 weeks 1.4 1.9 3.6 1.8 1.4 1.2 -1.4 1.9 -0.1 0.5 1.7 1.4
Hearing difficulty/problems: Yes 3.5 5.3 12.2 -2.4 -1.9 -2.7 2.1 -2.2 1.1 -3.5 -1.9 -2.2
Relative age of first facial hair 1.1 2.2 3.4 -1.3 -1.4 -0.9 1.8 -1.4 1.1 -1.7 -1.9 -1.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 -0.3 0.9 -0.5 -1.0 0.3 0.1 -0.4 0.5 0.9
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.3 -1.5 -1.0 -1.2 0.9 -1.2 0.2 0.5 -1.1 -1.0
Ever had hysterectomy (womb removed) 1.5 1.7 3.9 -1.5 -1.3 -1.1 1.0 -1.3 2.0 -1.1 -1.2 -1.2
Systolic blood pressure, automated reading 1.0 2.8 7.3 -2.7 -1.8 -1.9 1.5 -1.9 -0.2 -0.7 -1.2 -1.8
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 3.5 -1.3 -1.8 -1.7 1.7 -1.4 0.7 -0.5 -1.9 -1.7
Angina 0.8 1.1 5.6 -0.4 -0.4 -1.2 0.7 -0.3 2.4 -1.0 -0.5 -0.7
Medication for hormone replacement therapy 0.4 0.5 1.0 -0.3 -0.8 -0.2 0.9 -0.8 -0.3 0.2 -1.0 -0.8
Vitamin and mineral supplements 0.4 0.5 1.3 1.0 0.0 0.9 -0.0 0.6 1.1 -1.0 -0.0 0.1
Supplements: Zinc 0.2 0.3 1.2 0.4 -0.3 0.0 0.2 0.0 0.9 -1.1 -0.2 -0.1
Medication: Co-codamol 1.1 1.3 2.4 -0.5 -1.4 -0.3 1.3 -1.0 1.6 -0.6 -1.4 -1.3
Medication: Metformin 1.4 1.9 5.5 -0.4 -1.1 -1.6 1.4 -0.4 1.5 -2.4 -1.4 -1.3
Diabetes (father) 3.4 4.2 6.4 -2.0 -1.8 -2.0 2.4 -1.9 0.9 -2.5 -2.1 -2.3
Diabetes (mother) 0.6 0.8 2.4 0.5 0.8 -0.0 -0.5 1.1 -1.5 -1.3 0.7 0.5
Severe depression (siblings) 0.6 0.7 1.4 -1.0 -0.8 0.4 0.7 -1.2 0.8 0.7 -0.5 -0.8
Pack years adult smoking proportion 0.7 1.0 3.6 -1.9 -0.6 -1.1 0.9 -1.0 0.9 0.2 -0.4 -1.1
Impedance of leg (right) 0.5 2.4 5.8 -0.9 -2.2 -1.1 1.6 -1.5 -0.6 -1.2 -2.4 -1.6
Leg fat-free mass (left) 0.2 1.2 3.3 0.0 1.2 0.5 -1.6 0.7 -0.5 0.6 1.8 1.4
Trunk fat percentage 0.3 1.4 3.3 -1.8 0.6 -1.8 -0.8 -0.4 -1.8 0.1 1.0 0.5
Hand grip strength (right) 1.6 4.5 9.7 2.7 1.6 3.1 -1.8 2.2 0.3 2.3 1.9 1.9
Townsend deprivation index at recruitment 0.2 0.3 0.8 0.9 0.2 0.9 0.4 0.8 -0.1 -0.3 0.1 -0.3
Current tobacco smoking 0.8 1.4 2.4 -1.5 -0.8 -1.3 1.3 -0.9 1.3 1.1 -0.6 -1.4
Average weekly fortified wine intake 1.1 1.3 3.2 0.0 1.6 0.2 -1.7 0.8 -0.8 -0.1 1.8 1.5
Maternal smoking around birth 0.1 0.1 0.4 -0.0 -0.5 0.4 0.1 -0.1 -0.6 0.2 -0.2 -0.1
Fed-up feelings 0.1 0.2 1.6 0.4 -0.1 -0.0 0.3 0.0 1.3 0.6 -0.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 4.0 2.0 1.4 1.7 -1.5 2.0 -0.8 1.0 1.6 1.5
Relative age voice broke 1.6 2.5 3.3 -1.6 -1.3 -1.4 1.8 -1.4 1.4 -1.7 -1.6 -1.8
Taking other prescription medications 0.2 0.2 0.5 0.7 0.6 0.4 -0.3 0.5 -0.0 0.7 0.4 0.4
Age when periods started (menarche) 0.6 1.5 2.0 -1.3 -1.4 -0.7 1.4 -1.4 0.5 -1.4 -1.4 -1.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.7 -0.2 -0.9 0.1 0.9 -0.3 1.3 -1.0 -0.6 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.5 -1.6 -0.9 -0.6 0.5 -1.1 0.3 -1.3 -0.8 -0.7
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.0 -1.2 -1.4 -0.4 0.9 -1.2 0.2 -1.0 -1.2 -0.9
Qualifications: CSEs or equivalent 0.2 0.2 1.3 0.2 0.3 0.2 -0.5 0.2 -1.1 0.3 0.2 0.4
Serious illness, injury or assault to yourself 0.3 0.4 1.3 -0.8 0.4 -0.6 -0.3 -0.5 1.1 -1.0 0.1 0.3
High blood pressure 0.5 1.3 5.1 -2.3 0.0 -1.8 -0.1 -0.8 -1.4 -0.9 0.3 -0.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 3.3 0.0 0.8 0.7 -0.9 0.6 -1.8 -0.7 0.9 0.8
Multivitamins +/- minerals 0.5 0.7 2.6 -0.1 0.7 -0.3 -0.5 0.1 -1.4 1.6 0.6 0.5
Stomach or abdominal pain in last month 0.1 0.1 0.5 -0.7 -0.1 -0.3 -0.1 -0.6 0.1 -0.3 0.0 0.1
Supplements: Glucosamine 3.0 3.9 6.2 -2.1 -2.3 -1.9 1.8 -2.5 0.8 -1.9 -2.2 -1.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.2 0.6 -0.1 -0.7 -0.0 -0.6 0.4 0.2 0.6
Medication: Atenolol 0.6 0.7 1.6 -1.2 -0.4 -1.3 0.9 -0.9 0.0 -0.9 -0.3 -0.9
Medication: Levothyroxine sodium 0.1 0.2 1.2 0.0 0.5 -0.0 -0.4 0.1 -0.4 1.1 0.3 0.4
Sitting height 0.2 1.4 5.3 -0.2 -2.3 -0.8 0.9 -1.1 -0.3 -1.1 -1.5 -1.0
Chronic bronchitis/emphysema (father) 0.3 0.4 1.4 0.4 -0.9 0.2 0.6 0.1 0.5 0.2 -1.2 -0.5
High blood pressure (mother) 1.0 1.3 3.9 -2.0 -0.5 -0.8 -0.1 -1.1 -1.6 -1.9 -0.4 -0.1
Body mass index (BMI) 0.6 2.7 7.1 -1.0 2.2 -0.7 -1.9 0.7 -1.9 0.5 2.7 1.6
Impedance of leg (left) 0.3 1.6 4.5 -0.2 -1.9 -0.6 1.4 -1.1 -0.6 -0.8 -2.1 -1.3
Leg predicted mass (left) 0.2 1.1 3.2 -0.0 1.1 0.4 -1.6 0.7 -0.5 0.7 1.8 1.4
Trunk fat mass 0.4 1.7 4.2 -1.4 1.1 -1.3 -1.5 0.1 -2.1 0.3 1.6 1.1
Waist circumference 1.3 4.8 10.9 -0.2 3.0 -0.0 -2.7 1.6 -2.3 1.5 3.3 2.4
Number of incorrect matches in round 0.1 0.2 0.6 0.0 0.4 0.4 -0.4 0.4 0.8 -0.0 0.3 0.4
Past tobacco smoking 0.1 0.3 1.4 -0.6 0.2 -0.1 0.0 -0.5 -0.4 -1.2 0.3 -0.1
Alcohol usually taken with meals 1.0 1.6 3.3 0.4 1.4 0.4 -1.8 0.7 -1.8 0.8 1.4 1.8
Nervous feelings 0.0 0.1 0.2 0.2 0.3 0.3 -0.0 0.3 0.2 -0.4 -0.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 0.6 0.9 -0.0 -0.6 0.7 0.4 0.1 0.6 0.6
Hearing difficulty/problems with background noise 0.8 1.3 2.1 -0.8 -1.4 -0.5 1.1 -1.1 1.2 -1.5 -1.2 -1.1
Hair/balding pattern: Pattern 2 0.2 0.3 0.5 -0.7 -0.6 0.5 0.6 -0.6 0.1 0.3 -0.4 -0.5
Had menopause 0.1 0.1 0.8 -0.3 -0.2 0.0 -0.1 0.2 0.9 -0.6 0.1 -0.0
Had other major operations 0.3 0.4 2.9 0.2 -0.4 0.3 0.2 -0.4 1.7 0.4 -0.4 -0.1
Forced vital capacity (FVC) 0.5 1.7 4.7 0.8 -2.0 1.1 1.2 -0.9 2.2 -0.7 -1.2 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 4.2 -2.0 -1.3 -1.0 0.7 -1.6 0.4 -1.4 -1.0 -0.9
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 0.1 -0.1 0.4 -0.0 -0.2 0.4 -0.4 -0.3 0.1
Qualifications: None of the above 1.8 3.8 6.5 -1.3 -2.2 -1.1 2.5 -1.7 2.5 -0.9 -2.1 -2.4
Financial difficulties in last 2 years 0.3 0.4 2.5 0.0 -0.3 0.5 0.5 -0.5 1.6 0.0 -0.6 -0.4
Mouth/teeth dental problems 0.3 0.5 0.8 0.8 0.8 0.4 -0.8 0.9 -0.5 -0.4 0.9 0.8
Heart attack 0.1 0.1 0.3 0.2 0.6 -0.6 -0.3 0.4 0.0 0.3 0.4 0.3
Allergy 0.2 0.4 1.5 1.0 0.5 -0.0 -0.0 0.5 1.2 1.0 0.3 0.2
Pain all over the body in last month 0.5 0.5 1.2 1.1 0.7 0.7 -0.4 0.9 0.6 0.9 0.4 0.4
Diabetes (self-reported) 1.9 2.9 5.1 -0.9 -1.5 -2.1 1.8 -1.0 1.8 -2.3 -1.8 -1.8
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 2.3 -1.3 -1.3 -0.5 1.3 -1.5 1.1 -1.4 -1.2 -1.3
Medication: Ramipril 0.4 0.5 2.2 1.5 0.0 0.6 0.1 1.0 0.2 0.9 -0.2 0.0
Medication: Simvastatin 0.3 0.4 1.4 -0.1 -0.2 -1.1 0.6 -0.2 0.4 -1.2 -0.6 -0.4
Fluid intelligence score 0.1 0.3 0.7 -0.0 0.7 -0.0 -0.7 0.4 -0.8 -0.1 0.6 0.7
Illnesses of siblings 0.7 1.0 3.2 -0.5 -0.9 -0.1 1.1 -1.2 1.8 0.8 -0.7 -1.0
Neuroticism score 0.1 0.2 0.6 0.3 0.3 0.3 -0.3 0.3 0.8 0.6 0.1 0.4
Weight 0.4 2.2 5.6 -0.8 1.6 -0.4 -1.9 0.6 -1.9 0.5 2.4 1.6
Impedance of arm (right) 0.5 2.1 6.2 0.0 -2.0 -0.4 1.9 -1.1 0.9 -0.6 -2.5 -1.7
Arm fat percentage (right) 0.5 1.8 4.6 -1.1 1.6 -1.1 -1.4 0.3 -2.1 0.4 1.9 1.1
Trunk fat-free mass 0.3 1.9 4.4 0.3 1.4 0.8 -2.0 1.0 -1.1 0.5 2.1 1.8
Hip circumference 0.5 2.2 6.8 -0.7 1.3 -0.1 -1.7 0.5 -2.6 1.0 2.1 1.4
Time employed in main current job 0.3 0.3 0.7 0.1 0.8 -0.1 -0.7 0.5 0.5 0.4 0.8 0.6
Alcohol intake versus 10 years previously 2.1 3.2 4.7 -1.7 -2.0 -2.1 1.9 -1.6 1.5 -0.8 -2.2 -1.9
Father’s age at death 0.5 0.6 1.6 -1.1 -0.5 -0.9 0.1 -1.0 -0.6 -1.3 -0.5 -0.2
Worrier / anxious feelings 1.0 1.8 3.8 1.9 1.0 1.9 -1.5 1.5 0.5 0.7 0.8 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.1 0.2 0.8 -0.2 -0.9 0.6 -1.1 -0.5 0.7 0.8
Falls in the last year 0.3 0.4 0.8 -0.0 0.8 -0.5 -0.9 0.4 -0.2 0.6 0.4 0.8
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 -0.0 0.5 -0.3 -0.9 0.6 -0.6 -0.2 0.7 0.7
Number of live births 0.1 0.2 0.7 -0.2 -0.7 0.3 0.4 -0.4 0.1 -0.2 -0.8 -0.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 4.4 2.0 0.1 2.1 -0.6 0.7 1.4 -0.5 0.5 0.8
Pulse rate 1.1 1.9 2.8 1.5 1.6 0.9 -1.6 1.7 -1.0 0.3 1.5 1.6
Happiness 1.1 1.4 3.1 1.7 1.0 1.4 -1.0 1.8 -0.4 0.3 1.1 1.1
Noisy workplace 2.9 3.6 6.3 -2.5 -2.0 -1.8 1.8 -2.3 0.4 -1.5 -2.0 -1.9
Qualifications: A levels/AS levels or equivalent 1.5 3.3 4.8 1.9 1.8 1.2 -2.1 1.8 -1.9 1.5 1.8 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.5 -0.6 -0.0 -0.3 -0.2 -0.3 -0.7 -0.2 -0.3 0.1
Mouth/teeth dental problems: Dentures 1.0 1.7 2.8 -1.3 -1.2 -1.2 1.7 -1.3 1.1 -0.7 -1.4 -1.7
Asthma 4.8 9.5 15.4 -3.5 -3.7 -2.6 2.9 -3.9 0.7 -2.6 -3.4 -3.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.3 -0.7 -1.2 -0.4 1.1 -0.9 0.3 -0.1 -1.2 -1.1
Medication: Cholesterol lowering 0.4 0.6 1.3 0.8 0.9 -0.2 -0.8 1.1 -0.0 -0.0 1.0 0.8
Depression (self-reported) 0.1 0.1 0.3 -0.3 0.3 -0.0 0.2 -0.1 0.6 -0.4 0.2 -0.2
Medication: Lansoprazole 4.8 5.4 6.7 2.5 2.5 2.3 -2.4 2.6 -0.5 2.4 2.4 2.5
Prospective memory result 0.4 0.5 1.5 -1.2 -0.7 -0.6 0.6 -1.0 0.6 -0.0 -0.4 -0.7
Lung cancer (father) 0.7 0.8 2.8 -1.7 -0.7 -0.2 0.9 -1.2 -0.4 -0.5 -0.8 -1.0
Illnesses of mother 1.1 1.3 6.0 1.1 0.9 0.8 -0.6 1.0 -1.0 2.4 0.6 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.0 1.5 -0.6 1.3 0.1 0.1 1.7 0.3 -0.4 0.2
Pulse wave Arterial Stiffness index 4.2 4.9 7.0 2.5 2.2 1.8 -2.1 2.6 -1.5 2.6 2.2 2.1
Impedance of arm (left) 0.9 4.1 10.6 -0.5 -2.8 -1.0 2.5 -1.7 1.1 -1.0 -3.3 -2.4
Arm fat mass (right) 0.6 2.4 5.1 -1.0 1.8 -1.0 -1.9 0.5 -2.2 0.3 2.3 1.5
Trunk predicted mass 0.4 2.0 4.7 0.3 1.4 0.8 -2.1 1.1 -1.2 0.6 2.2 1.9
Standing height 0.0 0.3 2.0 0.5 -1.4 0.6 -0.1 -0.2 0.0 -0.2 -0.6 0.0
Length of working week for main job 0.8 0.9 1.2 1.0 1.1 1.0 -0.8 1.0 -1.0 -0.2 1.1 0.8
Exposure to tobacco smoke at home 0.5 0.5 2.4 -1.3 0.3 0.1 -0.1 -0.6 -0.5 -1.6 0.2 0.0
Breastfed as a baby 0.2 0.2 0.7 -0.3 -0.4 -0.5 0.3 -0.3 -0.3 -0.6 -0.8 -0.3
Tense / ‘highly strung’ 0.3 0.6 1.4 0.8 0.9 0.2 -0.5 0.8 1.2 -0.8 0.7 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.5 -0.5 -0.2 -0.2 0.7 -0.7 1.6 0.4 -0.6 -0.6
Hair/balding pattern: Pattern 4 1.3 3.0 4.5 2.1 1.9 1.8 -1.9 2.0 0.2 0.9 1.8 2.0
Birth weight of first child 0.7 1.3 4.7 1.6 0.6 2.2 -0.5 0.9 1.3 0.5 0.7 0.6
Peak expiratory flow (PEF) 0.7 1.7 4.2 1.8 0.8 2.0 -1.5 1.2 -0.3 0.1 1.0 1.5
Pulse wave reflection index 5.8 7.2 10.6 2.5 2.8 2.2 -2.6 2.8 -1.9 3.3 3.0 2.7
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 0.6 0.4 0.7 -0.3 0.4 0.2 0.8 0.1 0.4
Loud music exposure frequency 1.0 1.1 2.2 -0.7 -1.1 -0.5 1.5 -1.0 0.1 -0.8 -1.5 -1.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.1 1.4 0.9 0.7 -1.3 1.1 -0.6 0.4 1.2 1.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.9 -1.4 -0.8 -0.6 0.6 -1.2 -0.4 -0.1 -1.1 -0.7
Blood clot in the leg (DVT) 0.3 0.4 2.6 0.1 0.1 -0.6 0.4 0.1 1.6 -0.4 -0.1 -0.3
Medication: Paracetamol 2.4 4.0 6.4 -2.2 -2.4 -1.3 2.1 -2.5 1.5 -0.3 -2.5 -2.1
Headache pain in last month 0.4 0.6 1.7 -1.3 -1.2 -0.5 0.4 -1.0 -0.6 -0.3 -0.5 -0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.3 -0.1 -0.5 0.7 0.5 -0.7 1.1 0.3 -0.4 -0.4
Glaucoma (self-reported) 1.6 1.9 6.4 -0.7 -1.3 -1.0 1.1 -1.2 2.5 -1.0 -1.7 -1.1
Gout (self-reported) 0.6 0.8 2.5 -1.6 0.1 -1.1 0.0 -1.1 0.8 -1.3 -0.2 -0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 -0.8 -0.1 -0.7 0.5 -0.7 0.5 0.6 -0.2 -0.4
Medication: Amlodipine 0.3 0.5 2.0 -0.5 0.5 -1.2 -0.2 0.2 -1.4 0.4 0.5 0.1
Medication: Ventolin 100micrograms inhaler 2.6 3.4 5.7 -2.1 -1.9 -1.1 1.8 -2.4 0.5 -2.3 -1.7 -1.9
Birth weight 0.0 0.0 0.1 0.2 -0.0 0.3 0.1 -0.2 0.3 0.2 0.1 -0.0
Chronic bronchitis/emphysema (mother) 2.1 2.4 4.1 -2.0 -1.7 -1.8 1.4 -2.0 1.0 0.7 -1.3 -1.6
High blood pressure (siblings) 0.7 1.0 2.7 0.1 1.1 0.1 -1.2 0.8 -1.6 -0.8 1.1 1.1
Forced vital capacity (FVC), Best measure 0.7 2.6 6.8 0.3 -2.6 0.3 1.7 -1.5 2.2 -0.5 -2.0 -1.5
Body fat percentage 0.5 2.1 5.9 -1.5 1.4 -1.4 -1.4 0.1 -2.4 0.5 1.8 1.1
Leg fat percentage (right) 0.8 2.8 7.2 -1.4 2.0 -0.9 -1.8 0.4 -2.7 0.6 2.4 1.5
Arm fat-free mass (right) 0.3 1.8 4.5 -0.3 1.3 0.3 -2.0 0.7 -1.2 0.4 2.1 1.8
Exposure to tobacco smoke outside home 0.3 0.4 1.3 -0.8 -0.8 -0.0 0.2 -0.5 -0.1 -1.1 -0.7 -0.3
Comparative body size at age 10 2.3 6.4 11.0 2.0 2.2 3.3 -2.4 2.2 -0.1 3.3 3.2 2.4
Number of full brothers 0.2 0.3 0.9 0.5 -0.7 -0.3 0.5 -0.0 0.4 -0.9 -0.7 -0.4
Worry too long after embarrassment 0.0 0.1 0.3 0.2 -0.3 0.0 0.2 -0.3 0.3 -0.2 -0.6 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.6 -0.5 0.4 -0.8 -0.1 -0.3 -0.4 0.4 0.1 0.1
Wheeze or whistling in the chest in last year 3.4 6.1 9.0 -3.0 -2.9 -1.6 2.2 -3.0 1.7 -2.5 -2.5 -2.4
Number of children fathered 0.3 0.3 1.7 0.1 0.7 0.4 -0.5 0.3 -0.2 -0.1 1.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.1 -0.4 -0.9 -0.6 0.7 -0.6 0.4 -0.2 -1.1 -0.6
Age at first live birth 1.4 2.5 5.7 2.4 0.8 2.1 -1.3 1.5 1.4 1.6 0.9 1.5
Pulse wave peak to peak time 3.7 4.3 7.1 -2.3 -2.1 -1.7 1.9 -2.5 1.3 -2.7 -2.0 -1.9
Health satisfaction 0.2 0.3 1.2 -0.4 -0.4 -0.7 0.1 -0.3 1.1 -0.1 -0.7 -0.2
Shortness of breath walking on level ground 0.1 0.2 0.6 -0.6 0.3 -0.6 -0.2 -0.0 -0.3 -0.7 0.3 0.1
Qualifications: College or University degree 0.6 1.9 4.3 1.7 0.7 1.5 -1.0 1.3 -2.1 1.6 0.8 1.0
Eye problems/disorders: None of the above 1.8 2.0 3.5 1.9 1.2 1.6 -1.2 1.7 -1.4 1.0 1.4 1.3
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.1 0.7 0.1 1.1 -0.1 0.1 0.9 -0.7 -0.2 0.2
Emphysema/chronic bronchitis 1.3 1.4 2.3 0.7 1.1 1.0 -1.4 1.2 -0.7 1.5 1.4 1.3
Medication for pain relief, constipation, heartburn 0.7 1.2 1.8 1.4 1.0 1.1 -1.2 1.1 -1.2 0.4 1.3 1.2
Neck or shoulder pain in last month 0.8 1.1 2.1 0.6 1.1 0.7 -1.2 1.2 -1.4 -0.3 1.3 1.1
Medication: Blood pressure 0.3 0.4 2.5 -0.5 0.2 -0.8 -0.4 0.1 -1.6 0.6 0.1 0.3
Angina (self-reported) 0.6 0.8 4.8 -0.1 -0.3 -1.0 0.6 -0.1 2.2 -0.8 -0.4 -0.5
Migraine (self-reported) 0.4 0.5 2.5 0.1 -0.1 -0.3 -0.1 0.0 -1.4 1.6 -0.3 0.1
Medication: Ibuprofen 0.5 0.6 1.2 -0.9 -0.8 -0.3 1.1 -1.0 0.0 -0.3 -0.8 -1.1
Medication: Allopurinol 0.2 0.2 1.0 -0.6 0.1 -0.4 0.1 -0.4 1.0 -0.4 -0.1 -0.1
Medication: Omeprazole 3.7 4.5 7.5 2.2 2.7 1.5 -2.4 2.5 -0.8 0.9 2.5 2.5
Medication: Seretide 50 evohaler 0.7 0.8 2.0 -0.4 -1.1 0.4 0.9 -0.8 1.4 -0.7 -0.9 -0.9
Mean time to correctly identify matches 1.2 2.3 4.0 -1.7 -1.4 -2.0 1.6 -1.7 0.7 -0.8 -1.8 -1.6
Heart disease (mother) 0.3 0.4 1.2 -0.2 0.1 1.1 -0.6 0.1 0.4 -1.1 0.4 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.2 5.1 7.7 1.5 2.7 1.8 -2.6 2.1 -1.9 2.0 2.8 2.5
Whole body fat mass 0.5 2.2 4.7 -1.1 1.6 -0.9 -1.8 0.5 -2.2 0.5 2.1 1.5
Leg fat mass (right) 0.6 2.3 5.4 -1.0 1.7 -0.4 -1.9 0.6 -2.2 0.4 2.3 1.5
Arm predicted mass (right) 0.3 1.4 3.7 -0.4 1.1 0.3 -1.8 0.6 -1.1 0.4 1.9 1.6
Pulse rate, automated reading 2.1 6.7 10.3 2.2 3.1 1.1 -2.6 3.0 -3.2 1.6 3.0 2.6
Alcohol intake frequency. 0.5 1.2 2.6 -0.8 -1.4 -0.6 1.3 -1.1 0.2 -1.0 -1.6 -1.3
Comparative height size at age 10 0.1 0.5 1.1 1.0 -0.2 1.0 -0.8 0.4 0.4 0.6 0.5 0.8
Number of full sisters 0.4 0.5 1.6 0.4 -0.7 -0.3 0.8 0.2 -0.1 -1.3 -0.9 -0.7
Suffer from ‘nerves’ 0.1 0.2 0.9 -0.3 0.3 -0.9 -0.3 0.2 0.5 -0.3 0.4 0.2
Overall health rating 0.2 0.5 1.2 0.4 0.8 -0.6 -0.8 1.1 -0.2 -0.3 0.6 0.8
Chest pain or discomfort 1.1 1.6 6.5 -1.1 -1.2 -1.1 0.7 -0.9 -0.5 -2.5 -1.3 -0.8
Had major operations 1.1 1.3 2.8 0.7 1.2 0.5 -1.3 1.0 -1.7 1.1 1.1 1.2
Age at last live birth 0.5 0.7 2.0 1.3 -0.0 1.1 -0.2 0.5 1.4 1.1 0.2 0.4
Family relationship satisfaction 1.3 1.6 2.8 -0.3 -1.5 -0.9 1.6 -1.0 1.5 -0.8 -1.7 -1.5
Leg pain on walking 1.9 2.3 4.7 -2.2 -1.4 -1.4 1.4 -2.0 0.9 0.3 -1.7 -1.5
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 1.8 -1.3 -0.9 -1.3 1.1 -0.9 -0.6 -1.3 -1.0 -1.2
Commuting to job workplace: Car/motor vehicle 1.8 2.1 5.8 0.1 1.5 -0.3 -1.9 1.0 -2.4 1.1 1.5 1.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.3 0.4 -0.1 -0.2 0.2 0.5 -1.1 1.1 0.0 -0.2
Medication: Aspirin 0.6 0.8 1.7 -1.2 -0.7 -1.3 0.9 -0.6 0.4 -0.8 -1.0 -1.0
Supplements: Vitamin C 1.4 1.6 2.8 -1.7 -1.4 -1.2 1.1 -1.5 0.7 -1.1 -1.4 -1.1
Knee pain experienced in last month 4.6 7.1 10.0 -2.2 -3.2 -1.5 3.1 -3.0 3.1 -0.1 -3.2 -3.0
Hypertension (Self-reported) 0.5 1.3 4.3 -2.1 0.0 -1.9 -0.2 -0.7 -1.7 -0.6 0.3 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.6 4.2 8.3 2.7 2.0 2.9 -1.9 2.4 -0.3 1.0 1.8 2.1
Illnesses of father: Heart disease 2.5 3.5 6.8 2.6 1.8 2.2 -1.9 2.5 0.1 0.5 1.6 2.0
Illnesses of siblings: Diabetes 0.6 0.7 3.0 0.2 0.8 -0.5 -0.7 0.9 -0.8 -1.7 0.5 0.6
Smoking status: Previous 0.2 0.3 1.1 1.1 -0.5 0.4 0.2 0.5 0.4 0.5 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 4.0 -1.7 -2.0 -1.5 1.3 -2.0 0.9 -0.1 -1.6 -1.3
Whole body fat-free mass 0.3 1.8 4.5 0.2 1.4 0.7 -2.0 1.0 -0.9 0.7 2.1 1.8
Leg fat-free mass (right) 0.3 1.5 3.7 0.4 1.3 0.8 -1.7 1.0 -0.4 0.8 1.9 1.6
Arm fat percentage (left) 0.4 1.5 3.8 -1.5 1.2 -1.5 -1.0 -0.1 -1.9 0.1 1.4 0.7
Average weekly red wine intake 0.5 0.8 2.9 0.2 0.8 0.2 -1.1 0.1 -0.7 1.7 0.8 1.1
Handedness (chirality/laterality): Left-handed 1.6 2.0 4.9 -1.7 -1.2 -1.4 1.4 -1.2 0.6 -2.2 -0.9 -1.4
Mood swings 0.5 0.8 1.3 -1.1 -0.8 -1.2 0.8 -1.0 1.0 -0.4 -0.9 -0.8
Loneliness, isolation 0.1 0.2 0.5 0.1 -0.4 -0.0 0.7 -0.0 0.7 0.2 -0.2 -0.6
Long-standing illness, disability or infirmity 0.5 0.8 1.9 -1.4 -0.2 -1.4 0.5 -0.9 0.7 -0.9 -0.8 -0.6
Ever had bowel cancer screening 1.7 2.0 4.5 0.7 1.7 -0.4 -2.1 1.5 -1.2 0.7 1.4 2.0
Diabetes diagnosed by doctor 1.8 3.0 6.2 -0.5 -1.5 -1.7 1.8 -0.7 2.4 -2.5 -1.8 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.1 3.2 -1.5 -1.6 -1.4 1.2 -1.8 1.7 -0.7 -1.6 -1.3
Friendships satisfaction 1.5 1.9 3.3 -0.4 -1.4 -0.6 1.8 -1.2 1.5 -1.3 -1.8 -1.7
Qualifications: nursing, teaching 0.6 0.9 2.0 -0.6 -1.4 -1.0 0.9 -0.9 -0.4 -0.5 -1.4 -0.9
Commuting to job workplace: Walk 0.6 0.6 2.0 -1.1 -0.6 -0.5 0.5 -0.9 1.4 -0.4 -0.3 -0.5
Eye problems/disorders: Cataract 1.2 1.4 5.1 -2.2 -0.3 -1.6 0.3 -1.2 -0.8 -1.3 -0.3 -0.6
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 3.4 1.6 1.2 1.8 -1.4 1.4 -0.9 1.4 1.5 1.5
Medication for cholesterol 0.3 0.4 1.1 -0.1 -0.7 -0.7 0.3 -0.6 1.0 0.8 -0.7 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 4.6 0.9 2.1 1.4 -2.0 1.4 0.4 2.0 2.0 2.0
Back pain experienced in last month 5.7 8.3 10.2 2.5 3.2 2.7 -3.2 3.2 -2.0 2.5 3.1 3.2
Mineral and other dietary supplements 2.1 2.8 6.1 2.5 1.6 1.6 -1.4 2.3 0.2 1.0 1.7 1.5
Breast cancer (self-reported) 3.5 4.1 7.5 2.7 2.2 2.2 -2.0 2.3 -0.2 0.5 2.3 2.2
Asthma (self-reported) 5.7 11.3 17.5 -3.7 -4.0 -2.8 3.3 -4.2 0.9 -2.9 -3.8 -3.5
Osteoporosis (self-reported) 6.3 7.8 12.3 1.9 3.1 2.1 -3.2 2.8 -3.5 1.9 2.9 3.1
Osteoarthritis (self-reported) 0.4 0.6 2.4 -1.6 -0.3 -1.0 0.1 -1.0 -0.1 -0.7 -0.4 -0.2
Medication: Aspirin 1.1 1.4 2.9 -1.4 -1.0 -1.7 1.0 -1.0 0.8 -0.7 -1.4 -1.1
Medication: Gliclazide 1.5 1.7 3.7 -1.4 -0.9 -1.8 1.2 -1.0 0.5 -1.9 -1.3 -1.2
Illnesses of father: None of the above (group 1) 1.4 1.7 4.2 -1.4 -1.4 -1.0 1.3 -2.1 0.2 -0.6 -1.4 -1.3
Smoking status: Current 1.0 1.6 2.9 -1.7 -1.0 -1.3 1.4 -1.2 1.4 0.8 -0.8 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 2.6 1.6 1.5 1.0 -1.3 1.4 0.3 0.7 1.5 1.5
Whole body water mass 0.3 1.9 4.8 0.3 1.4 0.8 -2.0 1.0 -1.0 0.7 2.2 1.8
Leg predicted mass (right) 0.3 1.4 3.6 0.4 1.3 0.7 -1.7 0.9 -0.4 0.8 1.9 1.5
Arm fat mass (left) 0.5 2.1 4.7 -1.0 1.7 -0.9 -1.8 0.5 -2.1 0.3 2.2 1.4
Number of self-reported non-cancer illnesses 0.2 0.3 0.7 -0.2 0.8 -0.4 -0.7 0.5 -0.0 -0.3 0.6 0.6
Average weekly champagne plus white wine intake 1.2 1.6 3.5 0.4 1.4 0.8 -1.9 0.8 -0.9 0.6 1.9 1.7
Miserableness 0.0 0.1 0.2 0.1 -0.1 0.4 -0.3 0.2 -0.3 0.5 -0.0 0.3
Guilty feelings 0.3 0.4 0.7 0.4 0.6 0.6 -0.8 0.5 0.7 0.6 0.4 0.9
Wears glasses or contact lenses 2.4 2.8 4.5 0.6 2.1 0.3 -2.1 1.7 -2.1 1.1 1.9 2.0
Ever taken oral contraceptive pill 0.3 0.4 2.6 0.5 -0.3 -0.0 0.3 0.1 0.3 1.6 -0.2 -0.2
Hearing aid user 2.7 3.1 4.2 -2.0 -1.6 -1.5 1.6 -1.7 2.0 -1.9 -1.5 -1.8
Mother’s age at death 1.2 1.4 2.3 -1.1 -1.1 -1.0 1.3 -1.4 0.7 -1.3 -1.5 -1.3
Financial situation satisfaction 0.3 0.3 1.0 0.7 -0.4 0.1 0.8 0.1 0.1 0.4 -1.0 -0.6
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.4 0.2 -0.1 -0.3 -0.3 0.4 -0.2 -0.6 0.4 0.2
Commuting to job workplace: Public transport 1.6 2.0 2.9 -1.0 -1.7 -0.3 1.7 -1.5 1.1 -1.4 -1.7 -1.6
Eye problems/disorders: Glaucoma 1.0 1.1 4.5 -0.6 -0.5 -1.0 0.9 -0.8 2.1 -1.2 -0.9 -0.8
Medication: Blood pressure 0.2 0.3 1.2 -0.2 0.9 0.4 -0.4 0.5 -0.3 -0.1 1.1 0.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.0 -0.2 0.7 -0.1 -0.6 0.5 -1.4 0.3 0.9 0.5
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.0 -1.4 -0.8 -1.2 0.6 -1.2 -0.5 -0.6 -1.1 -0.7
High cholesterol (Self-reported) 0.2 0.4 2.9 0.1 0.2 -0.8 0.0 0.3 -0.1 -1.7 0.3 0.0
Medication: Bendroflumethiazide 0.1 0.1 0.4 -0.6 0.3 -0.1 0.1 -0.2 -0.1 0.0 0.4 -0.2
Medication: Paracetamol 2.6 4.0 6.1 -2.2 -2.3 -1.3 2.2 -2.4 1.5 -0.0 -2.5 -2.2
Medication: Lisinopril 0.2 0.2 1.1 -1.1 0.2 -0.6 -0.1 -0.1 -0.5 -0.5 0.3 -0.1
Medication: Atorvastatin 1.0 1.2 6.7 0.3 -0.2 -0.5 0.5 0.3 1.7 -2.6 0.2 -0.5
Illnesses of father: High blood pressure 1.2 1.5 2.5 0.7 1.4 0.5 -1.5 1.1 -1.6 0.9 1.4 1.4
Alcohol drinker status: Never 1.4 1.7 4.1 2.0 0.9 1.9 -0.9 1.5 0.2 1.0 0.9 1.1
Ever smoked 0.1 0.3 1.7 -0.2 0.2 -0.4 -0.3 0.3 -0.3 1.3 0.3 0.2
Basal metabolic rate 0.4 2.0 5.2 -0.0 1.5 0.4 -2.0 0.9 -1.3 0.7 2.3 1.8
Leg fat percentage (left) 0.8 2.9 6.8 -1.2 2.0 -0.8 -1.8 0.6 -2.6 0.9 2.5 1.5
Arm fat-free mass (left) 0.5 2.5 6.5 -0.0 1.7 0.6 -2.3 1.0 -1.5 0.8 2.5 2.0
Number of operations (self-reported) 0.3 0.5 2.5 -0.4 -0.2 -0.5 0.3 -0.5 1.6 1.0 -0.2 -0.3
Average weekly beer plus cider intake 4.2 6.1 12.5 -0.8 -2.9 -1.2 3.0 -1.7 3.5 -1.7 -3.2 -2.8
Irritability 0.3 0.5 1.6 1.3 0.5 0.8 -0.3 0.7 0.9 -0.2 0.6 0.5
Risk taking 0.3 0.4 1.7 -0.8 0.1 -0.7 -0.1 -0.4 1.3 0.5 0.3 -0.0
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.0 1.0 -0.1 1.0 0.1 0.6 0.8 0.6 0.0 -0.0
Fractured/broken bones in last 5 years 1.0 1.3 2.4 0.5 1.1 1.0 -1.4 0.9 -1.5 1.1 1.0 1.3
Age started oral contraceptive pill 0.7 0.9 3.0 -0.9 -0.7 -0.6 1.0 -1.0 1.7 0.4 -0.8 -0.9
Diastolic blood pressure, automated reading 0.4 1.3 5.1 -0.6 1.1 -0.2 -1.1 0.4 -2.3 1.2 1.3 0.8
Ever depressed for a whole week 0.1 0.1 0.3 0.4 -0.2 -0.2 0.4 -0.1 0.4 -0.5 -0.5 -0.3
Unable to work because of sickness or disability 0.7 0.9 1.7 0.8 1.3 0.6 -1.1 1.1 0.5 0.6 1.2 1.1
Commuting to job workplace: Cycle 0.6 0.8 3.2 0.2 -0.9 0.8 0.9 -0.7 1.8 0.1 -0.7 -0.7
Myopia 0.5 0.7 2.2 1.0 0.8 0.7 -0.7 0.9 0.1 1.5 0.5 0.8
Vascular/heart problems diagnosed by doctor 0.4 1.1 4.4 2.1 -0.1 1.9 0.1 0.6 1.1 0.6 -0.3 0.2
Cholesterol lowering medication 1.2 1.7 8.9 -0.5 -0.6 -0.7 1.2 -0.5 1.5 -3.0 -0.6 -1.1
Medication: Omeprazole (e.g. Zanprol) 2.7 3.3 6.6 1.6 2.6 0.9 -2.0 2.1 -0.8 0.8 2.3 2.1
Pain experienced in last month 0.2 0.4 0.7 -0.3 -0.5 -0.7 0.7 -0.4 0.8 -0.5 -0.8 -0.6
Supplements: Calcium 1.8 2.0 4.5 1.2 1.6 1.0 -1.5 1.2 -2.1 1.0 1.2 1.6
Basal cell carcinoma (self-reported) 2.0 2.3 4.1 0.6 1.8 0.9 -1.9 1.3 -2.0 1.2 1.6 1.8
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 0.4 0.7 -0.4 -0.4 0.5 0.0 0.4 0.4 0.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.9 0.3 0.3 -0.6 0.3 0.3 1.4 -0.5 0.0 -0.2
Heart disease (siblings) 1.4 1.7 3.7 1.7 1.0 1.1 -1.1 1.9 -1.6 0.6 0.7 1.2
Alcohol drinker status: Previous 0.5 0.6 2.3 0.8 0.3 1.0 -0.2 0.7 0.9 -1.5 0.3 0.2
Pack years of smoking 0.8 1.2 3.4 -1.8 -0.6 -1.0 1.1 -1.1 1.4 0.2 -0.6 -1.2
Impedance of whole body 0.6 3.2 9.0 -0.4 -2.6 -1.0 2.2 -1.5 0.3 -1.0 -3.0 -2.1
Leg fat mass (left) 0.7 2.6 6.4 -0.9 1.9 -0.3 -2.0 0.7 -2.1 0.6 2.5 1.7
Arm predicted mass (left) 0.6 3.0 7.5 0.2 1.9 0.7 -2.5 1.2 -1.6 1.0 2.7 2.2