Hub : Genes

SYMPK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0250	2.9e-05	0.043	0.034	0.043	0.040	0.042	5.8e-06	5.1e-05	5.7e-06	1.2e-05	6.5e-06
2	GTEx	Cells Transformed fibroblasts	0.1770	0.0450	6.9e-06	0.140	NA	0.099	NA	0.128	1.2e-10	NA	7.5e-08	NA	7.5e-10
3	GTEx	Nerve Tibial	0.1498	0.0476	8.9e-04	0.049	NA	0.083	NA	0.075	2.2e-04	NA	1.8e-06	NA	5.4e-06
4	GTEx	Testis	0.2200	0.0740	2.5e-03	0.210	NA	0.179	NA	0.200	1.1e-09	NA	2.3e-08	NA	2.9e-09
5	METSIM	Adipose	0.0476	0.0169	6.7e-04	0.026	0.007	0.007	0.009	0.014	8.1e-05	2.3e-02	2.6e-02	1.3e-02	2.9e-03
6	YFS	Blood	0.0663	0.0150	9.8e-10	0.012	0.031	0.027	0.032	0.028	7.3e-05	1.7e-10	2.0e-09	1.2e-10	1.2e-09
7	TCGA	Breast Invasive Carcinoma	0.0283	0.0142	2.9e-03	0.020	0.010	0.017	NA	0.021	4.0e-05	2.8e-03	1.5e-04	NA	3.5e-05
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0719	0.0334	1.1e-03	0.043	0.012	0.020	NA	0.034	1.2e-05	1.6e-02	2.3e-03	NA	9.4e-05
9	TCGA	Prostate Adenocarcinoma	0.0870	0.0366	2.0e-05	0.063	0.034	0.044	NA	0.048	3.3e-07	1.5e-04	1.8e-05	NA	8.7e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.2	0.2	1.1	0.7	-0.3	-0.4	0.1	0.4	-0.1	1.1	-0.3	-0.0
Bipolar Disorder or Schizophrenia	0.2	0.6	2.0	0.2	-0.6	-1.2	0.5	-0.2	-0.0	1.4	-0.9	-0.4
Depressed Affect (Nagel 2018)	0.3	0.6	2.6	-0.6	-0.6	-0.7	0.7	-0.7	1.6	0.1	-0.5	-0.6
Depression (Nagel 2018)	1.2	1.8	3.6	1.9	1.2	1.4	-1.3	1.8	0.7	0.5	1.3	1.4
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.6	0.7	1.8	0.5	-1.8	1.4	-2.6	0.9	1.5	1.8
Neuroticism (Nagel 2018)	0.2	0.4	3.7	-0.1	0.1	-0.2	-0.1	-0.0	1.9	-0.1	0.0	0.2
Schizophrenia (2018)	0.2	0.5	1.7	-0.3	-0.5	-1.3	0.5	-0.5	0.1	1.0	-1.0	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	0.8	0.1	1.2	0.2	0.1	-1.0	1.1	-0.1	-0.1
Worry (Nagel 2018)	0.2	0.4	3.5	0.1	-0.1	-0.3	0.0	-0.1	1.9	-0.3	-0.3	0.0
Alzheimer’s Disease (in mother)	0.4	0.4	1.9	0.2	-0.3	-0.6	0.6	0.0	1.4	-0.7	0.0	-0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.1	0.1	-1.1	0.3	1.0	-0.1	1.4	-0.0	-0.7	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	5.9	0.9	-1.5	0.1	1.5	-0.2	2.4	0.0	-0.8	-1.4
Crohns Disease (2017)	0.4	0.9	6.4	-0.6	0.3	-2.5	0.1	-0.1	0.8	-0.5	-0.1	-0.2
Irritable Bowel Disease (IBD)	0.3	0.6	3.5	-0.6	1.0	-1.9	-0.4	0.1	0.4	-0.1	0.6	0.3
Ulcerative Colitis (UC)	0.1	0.3	0.9	-0.1	0.9	-0.2	-0.6	0.2	0.2	0.3	0.7	0.6
Major Depression (MDD)	1.9	2.3	6.3	-0.5	-1.6	-0.5	1.9	-1.2	2.5	-0.6	-1.8	-1.7
Reaction Time	2.0	3.8	7.1	-2.1	-1.8	-2.7	2.0	-2.2	0.6	-1.1	-2.3	-2.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.6	0.1	1.3	0.1	-1.4	0.8	-1.6	-0.1	0.9	1.3
Breast Cancer	0.6	1.4	2.1	0.8	1.4	1.1	-1.4	1.0	-1.1	0.7	1.4	1.4
Ovarian Cancer	0.7	0.9	2.8	1.7	0.5	1.7	-0.3	1.2	-0.1	-0.2	0.6	0.4
Prostate Cancer	1.2	1.7	3.3	1.2	1.4	1.6	-1.2	1.2	-0.7	1.0	1.8	1.2
Age at First Birth	0.1	0.2	0.6	-0.4	-0.3	-0.8	0.3	-0.3	0.3	-0.1	-0.6	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	1.9	3.8	0.4	1.4	1.0	-1.6	1.2	-1.9	1.5	1.6	1.5
Coronary Artery Disease (CAD)	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.5	0.3
Crohns Disease (2012)	0.2	0.3	1.4	-0.5	0.4	-1.2	0.3	0.1	0.8	-0.2	0.0	-0.3
Mean Putamen Volume	0.7	0.8	1.4	-0.4	-1.2	-0.1	1.2	-1.1	1.0	0.1	-1.0	-1.1
Fasting Glucose	0.1	0.2	0.7	-0.5	0.4	-0.8	0.0	-0.5	-0.4	0.2	-0.1	-0.0
HbA1C	1.7	1.9	3.5	-1.9	-1.2	-1.7	1.5	-1.4	0.4	-1.0	-1.4	-1.5
HDL Cholesterol	1.7	2.9	5.4	1.3	2.1	1.2	-2.1	1.9	-0.6	0.1	2.3	2.1
LDL Cholesterol	0.5	0.8	4.9	0.8	-0.3	0.4	0.1	0.6	1.1	-2.2	0.1	-0.1
Lupus	0.8	1.2	2.2	-0.9	-1.3	-1.5	1.3	-0.9	0.2	0.5	-1.2	-1.3
Neuroticism (2016)	1.5	2.2	3.7	1.9	1.5	1.6	-1.0	1.3	1.2	1.8	1.5	1.2
Primary Biliary Cirrhosis	3.4	4.8	8.6	1.8	2.7	1.6	-2.5	2.3	-1.6	1.1	2.9	2.5
Rheumatoid Arthritis	0.2	0.3	0.9	-0.6	0.5	-0.9	-0.4	0.1	-0.8	-0.4	0.4	0.3
Schizophrenia (2014)	0.3	0.7	1.8	-0.1	-0.9	-0.9	0.9	-0.6	0.5	0.8	-1.4	-0.8
Triglycerides	2.6	4.2	6.6	-2.1	-2.4	-2.3	2.3	-2.0	0.0	-1.1	-2.6	-2.4
Type 2 Diabetes (T2D) (2012)	1.6	1.8	7.5	0.0	0.0	0.0	0.0	0.0	0.0	-1.6	-2.7	-2.5
Ulcerative Colitis	0.9	1.4	3.6	-1.9	-0.5	-1.8	1.0	-1.3	0.4	-0.8	-0.7	-1.1
Blood Eosinophil Count	12.5	96.2	139.2	10.6	11.8	8.5	-10.5	11.5	-5.3	6.1	10.8	10.8
Blood Platelet Count	1.3	15.4	24.3	2.2	3.4	4.8	-4.9	3.2	-3.2	3.0	4.8	4.6
Blood Red Count	2.9	27.7	33.9	-4.9	-4.9	-5.3	5.8	-5.7	4.0	-5.5	-5.4	-5.7
Blood White Count	0.4	2.9	6.2	0.9	2.5	0.4	-2.2	1.7	-0.3	1.5	2.1	2.1
Heel T-Score	0.1	0.6	2.3	0.0	-0.1	1.5	-1.0	0.4	-1.0	0.2	0.8	0.8
BMI	1.0	5.5	13.5	-0.6	3.3	-0.2	-3.1	1.4	-2.1	1.0	3.7	2.8
Height	0.0	0.8	3.5	0.4	-1.9	1.2	0.4	-0.5	0.5	-0.5	-1.1	-0.5
Waist Hip Ratio (WHR)	0.3	1.5	4.8	0.4	2.2	-0.7	-1.5	1.1	0.3	0.7	1.4	1.5
Systolic Blood Pressure	1.7	8.5	14.9	-3.9	-3.5	-3.1	3.0	-3.3	-0.1	-1.1	-2.8	-3.3
Smoking Status	0.4	1.1	2.2	-0.9	-1.0	-1.1	1.1	-0.7	1.5	0.8	-0.8	-1.1
Allergy or Eczema	0.2	0.5	2.6	-0.3	0.6	0.1	-0.5	0.1	-1.6	-1.0	0.7	0.4
Cardiovascular Disease	0.4	1.2	2.6	-1.2	0.6	-1.6	-0.9	0.2	-1.4	-1.4	0.9	0.6
Hypothyroidism (self reported)	0.1	0.3	1.3	-0.7	0.1	0.1	0.2	-0.6	0.5	1.1	0.2	-0.2
Respiratory disease	4.1	9.1	13.9	-3.1	-3.7	-2.2	3.2	-3.6	0.7	-2.6	-3.4	-3.3
Type 2 Diabetes (T2D) (2018)	1.4	2.6	6.9	-0.8	-0.9	-2.5	1.4	-0.7	1.5	-2.6	-1.4	-1.4
Lung FEV1/FVC ratio	4.8	24.4	49.3	4.4	7.0	2.5	-5.7	5.8	-1.4	2.6	6.0	5.9
Lung FVC	0.7	3.4	7.8	0.8	-2.3	1.1	2.2	-1.0	2.8	-0.9	-2.1	-1.9
Neuroticism	0.1	0.2	1.7	-0.3	-0.1	-0.3	0.1	-0.2	1.3	0.1	-0.2	-0.1
Chronotype (morning person)	0.2	0.5	2.0	0.6	-1.1	0.5	0.4	-0.2	0.5	-1.4	-0.7	-0.4
Hair Pigment	0.1	3.6	9.6	-3.1	-1.8	-2.1	1.3	-2.6	0.6	-1.1	-1.6	-1.6
Tanning	0.3	4.0	5.5	-2.1	-2.0	-1.8	2.1	-2.4	1.8	-1.8	-1.8	-2.2
Hand grip strength (left)	1.7	4.4	8.4	2.4	1.9	2.9	-2.1	2.4	-0.4	1.5	2.3	2.1
Number of treatments/medications taken	0.1	0.1	0.7	-0.1	0.4	0.2	-0.2	0.2	-0.8	0.5	0.2	0.2
Average weekly spirits intake	0.1	0.1	0.5	-0.2	0.0	-0.1	0.7	-0.1	-0.1	-0.4	-0.1	-0.7
Sensitivity / hurt feelings	0.1	0.2	0.9	-0.5	0.1	0.5	-0.3	-0.2	0.9	0.3	-0.0	0.2
Frequency of depressed mood in last 2 weeks	1.4	1.9	3.6	1.8	1.4	1.2	-1.4	1.9	-0.1	0.5	1.7	1.4
Hearing difficulty/problems: Yes	3.5	5.3	12.2	-2.4	-1.9	-2.7	2.1	-2.2	1.1	-3.5	-1.9	-2.2
Relative age of first facial hair	1.1	2.2	3.4	-1.3	-1.4	-0.9	1.8	-1.4	1.1	-1.7	-1.9	-1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.3	0.9	-0.5	-1.0	0.3	0.1	-0.4	0.5	0.9
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.3	-1.5	-1.0	-1.2	0.9	-1.2	0.2	0.5	-1.1	-1.0
Ever had hysterectomy (womb removed)	1.5	1.7	3.9	-1.5	-1.3	-1.1	1.0	-1.3	2.0	-1.1	-1.2	-1.2
Systolic blood pressure, automated reading	1.0	2.8	7.3	-2.7	-1.8	-1.9	1.5	-1.9	-0.2	-0.7	-1.2	-1.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	3.5	-1.3	-1.8	-1.7	1.7	-1.4	0.7	-0.5	-1.9	-1.7
Angina	0.8	1.1	5.6	-0.4	-0.4	-1.2	0.7	-0.3	2.4	-1.0	-0.5	-0.7
Medication for hormone replacement therapy	0.4	0.5	1.0	-0.3	-0.8	-0.2	0.9	-0.8	-0.3	0.2	-1.0	-0.8
Vitamin and mineral supplements	0.4	0.5	1.3	1.0	0.0	0.9	-0.0	0.6	1.1	-1.0	-0.0	0.1
Supplements: Zinc	0.2	0.3	1.2	0.4	-0.3	0.0	0.2	0.0	0.9	-1.1	-0.2	-0.1
Medication: Co-codamol	1.1	1.3	2.4	-0.5	-1.4	-0.3	1.3	-1.0	1.6	-0.6	-1.4	-1.3
Medication: Metformin	1.4	1.9	5.5	-0.4	-1.1	-1.6	1.4	-0.4	1.5	-2.4	-1.4	-1.3
Diabetes (father)	3.4	4.2	6.4	-2.0	-1.8	-2.0	2.4	-1.9	0.9	-2.5	-2.1	-2.3
Diabetes (mother)	0.6	0.8	2.4	0.5	0.8	-0.0	-0.5	1.1	-1.5	-1.3	0.7	0.5
Severe depression (siblings)	0.6	0.7	1.4	-1.0	-0.8	0.4	0.7	-1.2	0.8	0.7	-0.5	-0.8
Pack years adult smoking proportion	0.7	1.0	3.6	-1.9	-0.6	-1.1	0.9	-1.0	0.9	0.2	-0.4	-1.1
Impedance of leg (right)	0.5	2.4	5.8	-0.9	-2.2	-1.1	1.6	-1.5	-0.6	-1.2	-2.4	-1.6
Leg fat-free mass (left)	0.2	1.2	3.3	0.0	1.2	0.5	-1.6	0.7	-0.5	0.6	1.8	1.4
Trunk fat percentage	0.3	1.4	3.3	-1.8	0.6	-1.8	-0.8	-0.4	-1.8	0.1	1.0	0.5
Hand grip strength (right)	1.6	4.5	9.7	2.7	1.6	3.1	-1.8	2.2	0.3	2.3	1.9	1.9
Townsend deprivation index at recruitment	0.2	0.3	0.8	0.9	0.2	0.9	0.4	0.8	-0.1	-0.3	0.1	-0.3
Current tobacco smoking	0.8	1.4	2.4	-1.5	-0.8	-1.3	1.3	-0.9	1.3	1.1	-0.6	-1.4
Average weekly fortified wine intake	1.1	1.3	3.2	0.0	1.6	0.2	-1.7	0.8	-0.8	-0.1	1.8	1.5
Maternal smoking around birth	0.1	0.1	0.4	-0.0	-0.5	0.4	0.1	-0.1	-0.6	0.2	-0.2	-0.1
Fed-up feelings	0.1	0.2	1.6	0.4	-0.1	-0.0	0.3	0.0	1.3	0.6	-0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.0	2.0	1.4	1.7	-1.5	2.0	-0.8	1.0	1.6	1.5
Relative age voice broke	1.6	2.5	3.3	-1.6	-1.3	-1.4	1.8	-1.4	1.4	-1.7	-1.6	-1.8
Taking other prescription medications	0.2	0.2	0.5	0.7	0.6	0.4	-0.3	0.5	-0.0	0.7	0.4	0.4
Age when periods started (menarche)	0.6	1.5	2.0	-1.3	-1.4	-0.7	1.4	-1.4	0.5	-1.4	-1.4	-1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.2	-0.9	0.1	0.9	-0.3	1.3	-1.0	-0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	-1.6	-0.9	-0.6	0.5	-1.1	0.3	-1.3	-0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	-1.2	-1.4	-0.4	0.9	-1.2	0.2	-1.0	-1.2	-0.9
Qualifications: CSEs or equivalent	0.2	0.2	1.3	0.2	0.3	0.2	-0.5	0.2	-1.1	0.3	0.2	0.4
Serious illness, injury or assault to yourself	0.3	0.4	1.3	-0.8	0.4	-0.6	-0.3	-0.5	1.1	-1.0	0.1	0.3
High blood pressure	0.5	1.3	5.1	-2.3	0.0	-1.8	-0.1	-0.8	-1.4	-0.9	0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.3	0.0	0.8	0.7	-0.9	0.6	-1.8	-0.7	0.9	0.8
Multivitamins +/- minerals	0.5	0.7	2.6	-0.1	0.7	-0.3	-0.5	0.1	-1.4	1.6	0.6	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.5	-0.7	-0.1	-0.3	-0.1	-0.6	0.1	-0.3	0.0	0.1
Supplements: Glucosamine	3.0	3.9	6.2	-2.1	-2.3	-1.9	1.8	-2.5	0.8	-1.9	-2.2	-1.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.2	0.6	-0.1	-0.7	-0.0	-0.6	0.4	0.2	0.6
Medication: Atenolol	0.6	0.7	1.6	-1.2	-0.4	-1.3	0.9	-0.9	0.0	-0.9	-0.3	-0.9
Medication: Levothyroxine sodium	0.1	0.2	1.2	0.0	0.5	-0.0	-0.4	0.1	-0.4	1.1	0.3	0.4
Sitting height	0.2	1.4	5.3	-0.2	-2.3	-0.8	0.9	-1.1	-0.3	-1.1	-1.5	-1.0
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	0.4	-0.9	0.2	0.6	0.1	0.5	0.2	-1.2	-0.5
High blood pressure (mother)	1.0	1.3	3.9	-2.0	-0.5	-0.8	-0.1	-1.1	-1.6	-1.9	-0.4	-0.1
Body mass index (BMI)	0.6	2.7	7.1	-1.0	2.2	-0.7	-1.9	0.7	-1.9	0.5	2.7	1.6
Impedance of leg (left)	0.3	1.6	4.5	-0.2	-1.9	-0.6	1.4	-1.1	-0.6	-0.8	-2.1	-1.3
Leg predicted mass (left)	0.2	1.1	3.2	-0.0	1.1	0.4	-1.6	0.7	-0.5	0.7	1.8	1.4
Trunk fat mass	0.4	1.7	4.2	-1.4	1.1	-1.3	-1.5	0.1	-2.1	0.3	1.6	1.1
Waist circumference	1.3	4.8	10.9	-0.2	3.0	-0.0	-2.7	1.6	-2.3	1.5	3.3	2.4
Number of incorrect matches in round	0.1	0.2	0.6	0.0	0.4	0.4	-0.4	0.4	0.8	-0.0	0.3	0.4
Past tobacco smoking	0.1	0.3	1.4	-0.6	0.2	-0.1	0.0	-0.5	-0.4	-1.2	0.3	-0.1
Alcohol usually taken with meals	1.0	1.6	3.3	0.4	1.4	0.4	-1.8	0.7	-1.8	0.8	1.4	1.8
Nervous feelings	0.0	0.1	0.2	0.2	0.3	0.3	-0.0	0.3	0.2	-0.4	-0.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.6	0.9	-0.0	-0.6	0.7	0.4	0.1	0.6	0.6
Hearing difficulty/problems with background noise	0.8	1.3	2.1	-0.8	-1.4	-0.5	1.1	-1.1	1.2	-1.5	-1.2	-1.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	-0.7	-0.6	0.5	0.6	-0.6	0.1	0.3	-0.4	-0.5
Had menopause	0.1	0.1	0.8	-0.3	-0.2	0.0	-0.1	0.2	0.9	-0.6	0.1	-0.0
Had other major operations	0.3	0.4	2.9	0.2	-0.4	0.3	0.2	-0.4	1.7	0.4	-0.4	-0.1
Forced vital capacity (FVC)	0.5	1.7	4.7	0.8	-2.0	1.1	1.2	-0.9	2.2	-0.7	-1.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	4.2	-2.0	-1.3	-1.0	0.7	-1.6	0.4	-1.4	-1.0	-0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.1	-0.1	0.4	-0.0	-0.2	0.4	-0.4	-0.3	0.1
Qualifications: None of the above	1.8	3.8	6.5	-1.3	-2.2	-1.1	2.5	-1.7	2.5	-0.9	-2.1	-2.4
Financial difficulties in last 2 years	0.3	0.4	2.5	0.0	-0.3	0.5	0.5	-0.5	1.6	0.0	-0.6	-0.4
Mouth/teeth dental problems	0.3	0.5	0.8	0.8	0.8	0.4	-0.8	0.9	-0.5	-0.4	0.9	0.8
Heart attack	0.1	0.1	0.3	0.2	0.6	-0.6	-0.3	0.4	0.0	0.3	0.4	0.3
Allergy	0.2	0.4	1.5	1.0	0.5	-0.0	-0.0	0.5	1.2	1.0	0.3	0.2
Pain all over the body in last month	0.5	0.5	1.2	1.1	0.7	0.7	-0.4	0.9	0.6	0.9	0.4	0.4
Diabetes (self-reported)	1.9	2.9	5.1	-0.9	-1.5	-2.1	1.8	-1.0	1.8	-2.3	-1.8	-1.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	2.3	-1.3	-1.3	-0.5	1.3	-1.5	1.1	-1.4	-1.2	-1.3
Medication: Ramipril	0.4	0.5	2.2	1.5	0.0	0.6	0.1	1.0	0.2	0.9	-0.2	0.0
Medication: Simvastatin	0.3	0.4	1.4	-0.1	-0.2	-1.1	0.6	-0.2	0.4	-1.2	-0.6	-0.4
Fluid intelligence score	0.1	0.3	0.7	-0.0	0.7	-0.0	-0.7	0.4	-0.8	-0.1	0.6	0.7
Illnesses of siblings	0.7	1.0	3.2	-0.5	-0.9	-0.1	1.1	-1.2	1.8	0.8	-0.7	-1.0
Neuroticism score	0.1	0.2	0.6	0.3	0.3	0.3	-0.3	0.3	0.8	0.6	0.1	0.4
Weight	0.4	2.2	5.6	-0.8	1.6	-0.4	-1.9	0.6	-1.9	0.5	2.4	1.6
Impedance of arm (right)	0.5	2.1	6.2	0.0	-2.0	-0.4	1.9	-1.1	0.9	-0.6	-2.5	-1.7
Arm fat percentage (right)	0.5	1.8	4.6	-1.1	1.6	-1.1	-1.4	0.3	-2.1	0.4	1.9	1.1
Trunk fat-free mass	0.3	1.9	4.4	0.3	1.4	0.8	-2.0	1.0	-1.1	0.5	2.1	1.8
Hip circumference	0.5	2.2	6.8	-0.7	1.3	-0.1	-1.7	0.5	-2.6	1.0	2.1	1.4
Time employed in main current job	0.3	0.3	0.7	0.1	0.8	-0.1	-0.7	0.5	0.5	0.4	0.8	0.6
Alcohol intake versus 10 years previously	2.1	3.2	4.7	-1.7	-2.0	-2.1	1.9	-1.6	1.5	-0.8	-2.2	-1.9
Father’s age at death	0.5	0.6	1.6	-1.1	-0.5	-0.9	0.1	-1.0	-0.6	-1.3	-0.5	-0.2
Worrier / anxious feelings	1.0	1.8	3.8	1.9	1.0	1.9	-1.5	1.5	0.5	0.7	0.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	0.2	0.8	-0.2	-0.9	0.6	-1.1	-0.5	0.7	0.8
Falls in the last year	0.3	0.4	0.8	-0.0	0.8	-0.5	-0.9	0.4	-0.2	0.6	0.4	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.0	0.5	-0.3	-0.9	0.6	-0.6	-0.2	0.7	0.7
Number of live births	0.1	0.2	0.7	-0.2	-0.7	0.3	0.4	-0.4	0.1	-0.2	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.4	2.0	0.1	2.1	-0.6	0.7	1.4	-0.5	0.5	0.8
Pulse rate	1.1	1.9	2.8	1.5	1.6	0.9	-1.6	1.7	-1.0	0.3	1.5	1.6
Happiness	1.1	1.4	3.1	1.7	1.0	1.4	-1.0	1.8	-0.4	0.3	1.1	1.1
Noisy workplace	2.9	3.6	6.3	-2.5	-2.0	-1.8	1.8	-2.3	0.4	-1.5	-2.0	-1.9
Qualifications: A levels/AS levels or equivalent	1.5	3.3	4.8	1.9	1.8	1.2	-2.1	1.8	-1.9	1.5	1.8	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.5	-0.6	-0.0	-0.3	-0.2	-0.3	-0.7	-0.2	-0.3	0.1
Mouth/teeth dental problems: Dentures	1.0	1.7	2.8	-1.3	-1.2	-1.2	1.7	-1.3	1.1	-0.7	-1.4	-1.7
Asthma	4.8	9.5	15.4	-3.5	-3.7	-2.6	2.9	-3.9	0.7	-2.6	-3.4	-3.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	-0.7	-1.2	-0.4	1.1	-0.9	0.3	-0.1	-1.2	-1.1
Medication: Cholesterol lowering	0.4	0.6	1.3	0.8	0.9	-0.2	-0.8	1.1	-0.0	-0.0	1.0	0.8
Depression (self-reported)	0.1	0.1	0.3	-0.3	0.3	-0.0	0.2	-0.1	0.6	-0.4	0.2	-0.2
Medication: Lansoprazole	4.8	5.4	6.7	2.5	2.5	2.3	-2.4	2.6	-0.5	2.4	2.4	2.5
Prospective memory result	0.4	0.5	1.5	-1.2	-0.7	-0.6	0.6	-1.0	0.6	-0.0	-0.4	-0.7
Lung cancer (father)	0.7	0.8	2.8	-1.7	-0.7	-0.2	0.9	-1.2	-0.4	-0.5	-0.8	-1.0
Illnesses of mother	1.1	1.3	6.0	1.1	0.9	0.8	-0.6	1.0	-1.0	2.4	0.6	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.0	1.5	-0.6	1.3	0.1	0.1	1.7	0.3	-0.4	0.2
Pulse wave Arterial Stiffness index	4.2	4.9	7.0	2.5	2.2	1.8	-2.1	2.6	-1.5	2.6	2.2	2.1
Impedance of arm (left)	0.9	4.1	10.6	-0.5	-2.8	-1.0	2.5	-1.7	1.1	-1.0	-3.3	-2.4
Arm fat mass (right)	0.6	2.4	5.1	-1.0	1.8	-1.0	-1.9	0.5	-2.2	0.3	2.3	1.5
Trunk predicted mass	0.4	2.0	4.7	0.3	1.4	0.8	-2.1	1.1	-1.2	0.6	2.2	1.9
Standing height	0.0	0.3	2.0	0.5	-1.4	0.6	-0.1	-0.2	0.0	-0.2	-0.6	0.0
Length of working week for main job	0.8	0.9	1.2	1.0	1.1	1.0	-0.8	1.0	-1.0	-0.2	1.1	0.8
Exposure to tobacco smoke at home	0.5	0.5	2.4	-1.3	0.3	0.1	-0.1	-0.6	-0.5	-1.6	0.2	0.0
Breastfed as a baby	0.2	0.2	0.7	-0.3	-0.4	-0.5	0.3	-0.3	-0.3	-0.6	-0.8	-0.3
Tense / ‘highly strung’	0.3	0.6	1.4	0.8	0.9	0.2	-0.5	0.8	1.2	-0.8	0.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.5	-0.5	-0.2	-0.2	0.7	-0.7	1.6	0.4	-0.6	-0.6
Hair/balding pattern: Pattern 4	1.3	3.0	4.5	2.1	1.9	1.8	-1.9	2.0	0.2	0.9	1.8	2.0
Birth weight of first child	0.7	1.3	4.7	1.6	0.6	2.2	-0.5	0.9	1.3	0.5	0.7	0.6
Peak expiratory flow (PEF)	0.7	1.7	4.2	1.8	0.8	2.0	-1.5	1.2	-0.3	0.1	1.0	1.5
Pulse wave reflection index	5.8	7.2	10.6	2.5	2.8	2.2	-2.6	2.8	-1.9	3.3	3.0	2.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	0.6	0.4	0.7	-0.3	0.4	0.2	0.8	0.1	0.4
Loud music exposure frequency	1.0	1.1	2.2	-0.7	-1.1	-0.5	1.5	-1.0	0.1	-0.8	-1.5	-1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.1	1.4	0.9	0.7	-1.3	1.1	-0.6	0.4	1.2	1.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.9	-1.4	-0.8	-0.6	0.6	-1.2	-0.4	-0.1	-1.1	-0.7
Blood clot in the leg (DVT)	0.3	0.4	2.6	0.1	0.1	-0.6	0.4	0.1	1.6	-0.4	-0.1	-0.3
Medication: Paracetamol	2.4	4.0	6.4	-2.2	-2.4	-1.3	2.1	-2.5	1.5	-0.3	-2.5	-2.1
Headache pain in last month	0.4	0.6	1.7	-1.3	-1.2	-0.5	0.4	-1.0	-0.6	-0.3	-0.5	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	-0.1	-0.5	0.7	0.5	-0.7	1.1	0.3	-0.4	-0.4
Glaucoma (self-reported)	1.6	1.9	6.4	-0.7	-1.3	-1.0	1.1	-1.2	2.5	-1.0	-1.7	-1.1
Gout (self-reported)	0.6	0.8	2.5	-1.6	0.1	-1.1	0.0	-1.1	0.8	-1.3	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	-0.8	-0.1	-0.7	0.5	-0.7	0.5	0.6	-0.2	-0.4
Medication: Amlodipine	0.3	0.5	2.0	-0.5	0.5	-1.2	-0.2	0.2	-1.4	0.4	0.5	0.1
Medication: Ventolin 100micrograms inhaler	2.6	3.4	5.7	-2.1	-1.9	-1.1	1.8	-2.4	0.5	-2.3	-1.7	-1.9
Birth weight	0.0	0.0	0.1	0.2	-0.0	0.3	0.1	-0.2	0.3	0.2	0.1	-0.0
Chronic bronchitis/emphysema (mother)	2.1	2.4	4.1	-2.0	-1.7	-1.8	1.4	-2.0	1.0	0.7	-1.3	-1.6
High blood pressure (siblings)	0.7	1.0	2.7	0.1	1.1	0.1	-1.2	0.8	-1.6	-0.8	1.1	1.1
Forced vital capacity (FVC), Best measure	0.7	2.6	6.8	0.3	-2.6	0.3	1.7	-1.5	2.2	-0.5	-2.0	-1.5
Body fat percentage	0.5	2.1	5.9	-1.5	1.4	-1.4	-1.4	0.1	-2.4	0.5	1.8	1.1
Leg fat percentage (right)	0.8	2.8	7.2	-1.4	2.0	-0.9	-1.8	0.4	-2.7	0.6	2.4	1.5
Arm fat-free mass (right)	0.3	1.8	4.5	-0.3	1.3	0.3	-2.0	0.7	-1.2	0.4	2.1	1.8
Exposure to tobacco smoke outside home	0.3	0.4	1.3	-0.8	-0.8	-0.0	0.2	-0.5	-0.1	-1.1	-0.7	-0.3
Comparative body size at age 10	2.3	6.4	11.0	2.0	2.2	3.3	-2.4	2.2	-0.1	3.3	3.2	2.4
Number of full brothers	0.2	0.3	0.9	0.5	-0.7	-0.3	0.5	-0.0	0.4	-0.9	-0.7	-0.4
Worry too long after embarrassment	0.0	0.1	0.3	0.2	-0.3	0.0	0.2	-0.3	0.3	-0.2	-0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	-0.5	0.4	-0.8	-0.1	-0.3	-0.4	0.4	0.1	0.1
Wheeze or whistling in the chest in last year	3.4	6.1	9.0	-3.0	-2.9	-1.6	2.2	-3.0	1.7	-2.5	-2.5	-2.4
Number of children fathered	0.3	0.3	1.7	0.1	0.7	0.4	-0.5	0.3	-0.2	-0.1	1.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.1	-0.4	-0.9	-0.6	0.7	-0.6	0.4	-0.2	-1.1	-0.6
Age at first live birth	1.4	2.5	5.7	2.4	0.8	2.1	-1.3	1.5	1.4	1.6	0.9	1.5
Pulse wave peak to peak time	3.7	4.3	7.1	-2.3	-2.1	-1.7	1.9	-2.5	1.3	-2.7	-2.0	-1.9
Health satisfaction	0.2	0.3	1.2	-0.4	-0.4	-0.7	0.1	-0.3	1.1	-0.1	-0.7	-0.2
Shortness of breath walking on level ground	0.1	0.2	0.6	-0.6	0.3	-0.6	-0.2	-0.0	-0.3	-0.7	0.3	0.1
Qualifications: College or University degree	0.6	1.9	4.3	1.7	0.7	1.5	-1.0	1.3	-2.1	1.6	0.8	1.0
Eye problems/disorders: None of the above	1.8	2.0	3.5	1.9	1.2	1.6	-1.2	1.7	-1.4	1.0	1.4	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	0.7	0.1	1.1	-0.1	0.1	0.9	-0.7	-0.2	0.2
Emphysema/chronic bronchitis	1.3	1.4	2.3	0.7	1.1	1.0	-1.4	1.2	-0.7	1.5	1.4	1.3
Medication for pain relief, constipation, heartburn	0.7	1.2	1.8	1.4	1.0	1.1	-1.2	1.1	-1.2	0.4	1.3	1.2
Neck or shoulder pain in last month	0.8	1.1	2.1	0.6	1.1	0.7	-1.2	1.2	-1.4	-0.3	1.3	1.1
Medication: Blood pressure	0.3	0.4	2.5	-0.5	0.2	-0.8	-0.4	0.1	-1.6	0.6	0.1	0.3
Angina (self-reported)	0.6	0.8	4.8	-0.1	-0.3	-1.0	0.6	-0.1	2.2	-0.8	-0.4	-0.5
Migraine (self-reported)	0.4	0.5	2.5	0.1	-0.1	-0.3	-0.1	0.0	-1.4	1.6	-0.3	0.1
Medication: Ibuprofen	0.5	0.6	1.2	-0.9	-0.8	-0.3	1.1	-1.0	0.0	-0.3	-0.8	-1.1
Medication: Allopurinol	0.2	0.2	1.0	-0.6	0.1	-0.4	0.1	-0.4	1.0	-0.4	-0.1	-0.1
Medication: Omeprazole	3.7	4.5	7.5	2.2	2.7	1.5	-2.4	2.5	-0.8	0.9	2.5	2.5
Medication: Seretide 50 evohaler	0.7	0.8	2.0	-0.4	-1.1	0.4	0.9	-0.8	1.4	-0.7	-0.9	-0.9
Mean time to correctly identify matches	1.2	2.3	4.0	-1.7	-1.4	-2.0	1.6	-1.7	0.7	-0.8	-1.8	-1.6
Heart disease (mother)	0.3	0.4	1.2	-0.2	0.1	1.1	-0.6	0.1	0.4	-1.1	0.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.2	5.1	7.7	1.5	2.7	1.8	-2.6	2.1	-1.9	2.0	2.8	2.5
Whole body fat mass	0.5	2.2	4.7	-1.1	1.6	-0.9	-1.8	0.5	-2.2	0.5	2.1	1.5
Leg fat mass (right)	0.6	2.3	5.4	-1.0	1.7	-0.4	-1.9	0.6	-2.2	0.4	2.3	1.5
Arm predicted mass (right)	0.3	1.4	3.7	-0.4	1.1	0.3	-1.8	0.6	-1.1	0.4	1.9	1.6
Pulse rate, automated reading	2.1	6.7	10.3	2.2	3.1	1.1	-2.6	3.0	-3.2	1.6	3.0	2.6
Alcohol intake frequency.	0.5	1.2	2.6	-0.8	-1.4	-0.6	1.3	-1.1	0.2	-1.0	-1.6	-1.3
Comparative height size at age 10	0.1	0.5	1.1	1.0	-0.2	1.0	-0.8	0.4	0.4	0.6	0.5	0.8
Number of full sisters	0.4	0.5	1.6	0.4	-0.7	-0.3	0.8	0.2	-0.1	-1.3	-0.9	-0.7
Suffer from ‘nerves’	0.1	0.2	0.9	-0.3	0.3	-0.9	-0.3	0.2	0.5	-0.3	0.4	0.2
Overall health rating	0.2	0.5	1.2	0.4	0.8	-0.6	-0.8	1.1	-0.2	-0.3	0.6	0.8
Chest pain or discomfort	1.1	1.6	6.5	-1.1	-1.2	-1.1	0.7	-0.9	-0.5	-2.5	-1.3	-0.8
Had major operations	1.1	1.3	2.8	0.7	1.2	0.5	-1.3	1.0	-1.7	1.1	1.1	1.2
Age at last live birth	0.5	0.7	2.0	1.3	-0.0	1.1	-0.2	0.5	1.4	1.1	0.2	0.4
Family relationship satisfaction	1.3	1.6	2.8	-0.3	-1.5	-0.9	1.6	-1.0	1.5	-0.8	-1.7	-1.5
Leg pain on walking	1.9	2.3	4.7	-2.2	-1.4	-1.4	1.4	-2.0	0.9	0.3	-1.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.8	-1.3	-0.9	-1.3	1.1	-0.9	-0.6	-1.3	-1.0	-1.2
Commuting to job workplace: Car/motor vehicle	1.8	2.1	5.8	0.1	1.5	-0.3	-1.9	1.0	-2.4	1.1	1.5	1.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.3	0.4	-0.1	-0.2	0.2	0.5	-1.1	1.1	0.0	-0.2
Medication: Aspirin	0.6	0.8	1.7	-1.2	-0.7	-1.3	0.9	-0.6	0.4	-0.8	-1.0	-1.0
Supplements: Vitamin C	1.4	1.6	2.8	-1.7	-1.4	-1.2	1.1	-1.5	0.7	-1.1	-1.4	-1.1
Knee pain experienced in last month	4.6	7.1	10.0	-2.2	-3.2	-1.5	3.1	-3.0	3.1	-0.1	-3.2	-3.0
Hypertension (Self-reported)	0.5	1.3	4.3	-2.1	0.0	-1.9	-0.2	-0.7	-1.7	-0.6	0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.6	4.2	8.3	2.7	2.0	2.9	-1.9	2.4	-0.3	1.0	1.8	2.1
Illnesses of father: Heart disease	2.5	3.5	6.8	2.6	1.8	2.2	-1.9	2.5	0.1	0.5	1.6	2.0
Illnesses of siblings: Diabetes	0.6	0.7	3.0	0.2	0.8	-0.5	-0.7	0.9	-0.8	-1.7	0.5	0.6
Smoking status: Previous	0.2	0.3	1.1	1.1	-0.5	0.4	0.2	0.5	0.4	0.5	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.0	-1.7	-2.0	-1.5	1.3	-2.0	0.9	-0.1	-1.6	-1.3
Whole body fat-free mass	0.3	1.8	4.5	0.2	1.4	0.7	-2.0	1.0	-0.9	0.7	2.1	1.8
Leg fat-free mass (right)	0.3	1.5	3.7	0.4	1.3	0.8	-1.7	1.0	-0.4	0.8	1.9	1.6
Arm fat percentage (left)	0.4	1.5	3.8	-1.5	1.2	-1.5	-1.0	-0.1	-1.9	0.1	1.4	0.7
Average weekly red wine intake	0.5	0.8	2.9	0.2	0.8	0.2	-1.1	0.1	-0.7	1.7	0.8	1.1
Handedness (chirality/laterality): Left-handed	1.6	2.0	4.9	-1.7	-1.2	-1.4	1.4	-1.2	0.6	-2.2	-0.9	-1.4
Mood swings	0.5	0.8	1.3	-1.1	-0.8	-1.2	0.8	-1.0	1.0	-0.4	-0.9	-0.8
Loneliness, isolation	0.1	0.2	0.5	0.1	-0.4	-0.0	0.7	-0.0	0.7	0.2	-0.2	-0.6
Long-standing illness, disability or infirmity	0.5	0.8	1.9	-1.4	-0.2	-1.4	0.5	-0.9	0.7	-0.9	-0.8	-0.6
Ever had bowel cancer screening	1.7	2.0	4.5	0.7	1.7	-0.4	-2.1	1.5	-1.2	0.7	1.4	2.0
Diabetes diagnosed by doctor	1.8	3.0	6.2	-0.5	-1.5	-1.7	1.8	-0.7	2.4	-2.5	-1.8	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	3.2	-1.5	-1.6	-1.4	1.2	-1.8	1.7	-0.7	-1.6	-1.3
Friendships satisfaction	1.5	1.9	3.3	-0.4	-1.4	-0.6	1.8	-1.2	1.5	-1.3	-1.8	-1.7
Qualifications: nursing, teaching	0.6	0.9	2.0	-0.6	-1.4	-1.0	0.9	-0.9	-0.4	-0.5	-1.4	-0.9
Commuting to job workplace: Walk	0.6	0.6	2.0	-1.1	-0.6	-0.5	0.5	-0.9	1.4	-0.4	-0.3	-0.5
Eye problems/disorders: Cataract	1.2	1.4	5.1	-2.2	-0.3	-1.6	0.3	-1.2	-0.8	-1.3	-0.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.4	1.6	1.2	1.8	-1.4	1.4	-0.9	1.4	1.5	1.5
Medication for cholesterol	0.3	0.4	1.1	-0.1	-0.7	-0.7	0.3	-0.6	1.0	0.8	-0.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	4.6	0.9	2.1	1.4	-2.0	1.4	0.4	2.0	2.0	2.0
Back pain experienced in last month	5.7	8.3	10.2	2.5	3.2	2.7	-3.2	3.2	-2.0	2.5	3.1	3.2
Mineral and other dietary supplements	2.1	2.8	6.1	2.5	1.6	1.6	-1.4	2.3	0.2	1.0	1.7	1.5
Breast cancer (self-reported)	3.5	4.1	7.5	2.7	2.2	2.2	-2.0	2.3	-0.2	0.5	2.3	2.2
Asthma (self-reported)	5.7	11.3	17.5	-3.7	-4.0	-2.8	3.3	-4.2	0.9	-2.9	-3.8	-3.5
Osteoporosis (self-reported)	6.3	7.8	12.3	1.9	3.1	2.1	-3.2	2.8	-3.5	1.9	2.9	3.1
Osteoarthritis (self-reported)	0.4	0.6	2.4	-1.6	-0.3	-1.0	0.1	-1.0	-0.1	-0.7	-0.4	-0.2
Medication: Aspirin	1.1	1.4	2.9	-1.4	-1.0	-1.7	1.0	-1.0	0.8	-0.7	-1.4	-1.1
Medication: Gliclazide	1.5	1.7	3.7	-1.4	-0.9	-1.8	1.2	-1.0	0.5	-1.9	-1.3	-1.2
Illnesses of father: None of the above (group 1)	1.4	1.7	4.2	-1.4	-1.4	-1.0	1.3	-2.1	0.2	-0.6	-1.4	-1.3
Smoking status: Current	1.0	1.6	2.9	-1.7	-1.0	-1.3	1.4	-1.2	1.4	0.8	-0.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.6	1.6	1.5	1.0	-1.3	1.4	0.3	0.7	1.5	1.5
Whole body water mass	0.3	1.9	4.8	0.3	1.4	0.8	-2.0	1.0	-1.0	0.7	2.2	1.8
Leg predicted mass (right)	0.3	1.4	3.6	0.4	1.3	0.7	-1.7	0.9	-0.4	0.8	1.9	1.5
Arm fat mass (left)	0.5	2.1	4.7	-1.0	1.7	-0.9	-1.8	0.5	-2.1	0.3	2.2	1.4
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.2	0.8	-0.4	-0.7	0.5	-0.0	-0.3	0.6	0.6
Average weekly champagne plus white wine intake	1.2	1.6	3.5	0.4	1.4	0.8	-1.9	0.8	-0.9	0.6	1.9	1.7
Miserableness	0.0	0.1	0.2	0.1	-0.1	0.4	-0.3	0.2	-0.3	0.5	-0.0	0.3
Guilty feelings	0.3	0.4	0.7	0.4	0.6	0.6	-0.8	0.5	0.7	0.6	0.4	0.9
Wears glasses or contact lenses	2.4	2.8	4.5	0.6	2.1	0.3	-2.1	1.7	-2.1	1.1	1.9	2.0
Ever taken oral contraceptive pill	0.3	0.4	2.6	0.5	-0.3	-0.0	0.3	0.1	0.3	1.6	-0.2	-0.2
Hearing aid user	2.7	3.1	4.2	-2.0	-1.6	-1.5	1.6	-1.7	2.0	-1.9	-1.5	-1.8
Mother’s age at death	1.2	1.4	2.3	-1.1	-1.1	-1.0	1.3	-1.4	0.7	-1.3	-1.5	-1.3
Financial situation satisfaction	0.3	0.3	1.0	0.7	-0.4	0.1	0.8	0.1	0.1	0.4	-1.0	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.2	-0.1	-0.3	-0.3	0.4	-0.2	-0.6	0.4	0.2
Commuting to job workplace: Public transport	1.6	2.0	2.9	-1.0	-1.7	-0.3	1.7	-1.5	1.1	-1.4	-1.7	-1.6
Eye problems/disorders: Glaucoma	1.0	1.1	4.5	-0.6	-0.5	-1.0	0.9	-0.8	2.1	-1.2	-0.9	-0.8
Medication: Blood pressure	0.2	0.3	1.2	-0.2	0.9	0.4	-0.4	0.5	-0.3	-0.1	1.1	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.0	-0.2	0.7	-0.1	-0.6	0.5	-1.4	0.3	0.9	0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	-1.4	-0.8	-1.2	0.6	-1.2	-0.5	-0.6	-1.1	-0.7
High cholesterol (Self-reported)	0.2	0.4	2.9	0.1	0.2	-0.8	0.0	0.3	-0.1	-1.7	0.3	0.0
Medication: Bendroflumethiazide	0.1	0.1	0.4	-0.6	0.3	-0.1	0.1	-0.2	-0.1	0.0	0.4	-0.2
Medication: Paracetamol	2.6	4.0	6.1	-2.2	-2.3	-1.3	2.2	-2.4	1.5	-0.0	-2.5	-2.2
Medication: Lisinopril	0.2	0.2	1.1	-1.1	0.2	-0.6	-0.1	-0.1	-0.5	-0.5	0.3	-0.1
Medication: Atorvastatin	1.0	1.2	6.7	0.3	-0.2	-0.5	0.5	0.3	1.7	-2.6	0.2	-0.5
Illnesses of father: High blood pressure	1.2	1.5	2.5	0.7	1.4	0.5	-1.5	1.1	-1.6	0.9	1.4	1.4
Alcohol drinker status: Never	1.4	1.7	4.1	2.0	0.9	1.9	-0.9	1.5	0.2	1.0	0.9	1.1
Ever smoked	0.1	0.3	1.7	-0.2	0.2	-0.4	-0.3	0.3	-0.3	1.3	0.3	0.2
Basal metabolic rate	0.4	2.0	5.2	-0.0	1.5	0.4	-2.0	0.9	-1.3	0.7	2.3	1.8
Leg fat percentage (left)	0.8	2.9	6.8	-1.2	2.0	-0.8	-1.8	0.6	-2.6	0.9	2.5	1.5
Arm fat-free mass (left)	0.5	2.5	6.5	-0.0	1.7	0.6	-2.3	1.0	-1.5	0.8	2.5	2.0
Number of operations (self-reported)	0.3	0.5	2.5	-0.4	-0.2	-0.5	0.3	-0.5	1.6	1.0	-0.2	-0.3
Average weekly beer plus cider intake	4.2	6.1	12.5	-0.8	-2.9	-1.2	3.0	-1.7	3.5	-1.7	-3.2	-2.8
Irritability	0.3	0.5	1.6	1.3	0.5	0.8	-0.3	0.7	0.9	-0.2	0.6	0.5
Risk taking	0.3	0.4	1.7	-0.8	0.1	-0.7	-0.1	-0.4	1.3	0.5	0.3	-0.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	1.0	-0.1	1.0	0.1	0.6	0.8	0.6	0.0	-0.0
Fractured/broken bones in last 5 years	1.0	1.3	2.4	0.5	1.1	1.0	-1.4	0.9	-1.5	1.1	1.0	1.3
Age started oral contraceptive pill	0.7	0.9	3.0	-0.9	-0.7	-0.6	1.0	-1.0	1.7	0.4	-0.8	-0.9
Diastolic blood pressure, automated reading	0.4	1.3	5.1	-0.6	1.1	-0.2	-1.1	0.4	-2.3	1.2	1.3	0.8
Ever depressed for a whole week	0.1	0.1	0.3	0.4	-0.2	-0.2	0.4	-0.1	0.4	-0.5	-0.5	-0.3
Unable to work because of sickness or disability	0.7	0.9	1.7	0.8	1.3	0.6	-1.1	1.1	0.5	0.6	1.2	1.1
Commuting to job workplace: Cycle	0.6	0.8	3.2	0.2	-0.9	0.8	0.9	-0.7	1.8	0.1	-0.7	-0.7
Myopia	0.5	0.7	2.2	1.0	0.8	0.7	-0.7	0.9	0.1	1.5	0.5	0.8
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.4	2.1	-0.1	1.9	0.1	0.6	1.1	0.6	-0.3	0.2
Cholesterol lowering medication	1.2	1.7	8.9	-0.5	-0.6	-0.7	1.2	-0.5	1.5	-3.0	-0.6	-1.1
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	6.6	1.6	2.6	0.9	-2.0	2.1	-0.8	0.8	2.3	2.1
Pain experienced in last month	0.2	0.4	0.7	-0.3	-0.5	-0.7	0.7	-0.4	0.8	-0.5	-0.8	-0.6
Supplements: Calcium	1.8	2.0	4.5	1.2	1.6	1.0	-1.5	1.2	-2.1	1.0	1.2	1.6
Basal cell carcinoma (self-reported)	2.0	2.3	4.1	0.6	1.8	0.9	-1.9	1.3	-2.0	1.2	1.6	1.8
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.4	0.7	-0.4	-0.4	0.5	0.0	0.4	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.9	0.3	0.3	-0.6	0.3	0.3	1.4	-0.5	0.0	-0.2
Heart disease (siblings)	1.4	1.7	3.7	1.7	1.0	1.1	-1.1	1.9	-1.6	0.6	0.7	1.2
Alcohol drinker status: Previous	0.5	0.6	2.3	0.8	0.3	1.0	-0.2	0.7	0.9	-1.5	0.3	0.2
Pack years of smoking	0.8	1.2	3.4	-1.8	-0.6	-1.0	1.1	-1.1	1.4	0.2	-0.6	-1.2
Impedance of whole body	0.6	3.2	9.0	-0.4	-2.6	-1.0	2.2	-1.5	0.3	-1.0	-3.0	-2.1
Leg fat mass (left)	0.7	2.6	6.4	-0.9	1.9	-0.3	-2.0	0.7	-2.1	0.6	2.5	1.7
Arm predicted mass (left)	0.6	3.0	7.5	0.2	1.9	0.7	-2.5	1.2	-1.6	1.0	2.7	2.2