[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr19:40,259,342-42,504,505

Best TWAS P=1.49e-15 · Best GWAS P=6.52e-13 conditioned to 0.0842

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	NTR	Blood	SHKBP1	0.05	0.04	enet	18	0.04	3.1e-13	-6.7	-8.0	1.5e-15	0.81	0.03	0.97	TRUE
9	GTEx	Skin Sun Exposed Lower leg	HNRNPUL1	0.09	0.01	lasso	6	0.01	6.8e-02	-5.5	-6.8	9.5e-12	-0.12	0.01	0.85	TRUE
8	GTEx	Muscle Skeletal	ITPKC	0.10	0.07	enet	24	0.05	4.2e-06	-4.1	6.3	2.4e-10	-0.07	0.96	0.00	TRUE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB4B	0.10	0.07	lasso	5	0.08	4.2e-09	-5.6	6.3	2.9e-10	0.10	0.00	1.00	TRUE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP2B7P1	0.20	0.03	blup	56	0.07	4.7e-08	2.2	5.3	1.4e-07	0.05	0.08	0.07	TRUE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	LTBP4	0.01	0.00	blup	54	0.01	2.0e-02	-6.5	7.3	3.5e-13	-0.86	0.02	0.54	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LTBP4	0.09	0.05	lasso	9	0.04	3.9e-06	-7.2	7.1	1.3e-12	-0.99	0.01	0.99	FALSE
7	GTEx	Lung	SHKBP1	0.12	0.12	enet	20	0.09	1.8e-07	-6.7	-7.1	1.6e-12	0.86	0.02	0.98	FALSE
10	GTEx	Whole Blood	SHKBP1	0.12	0.09	lasso	3	0.07	3.7e-07	-6.7	-6.7	2.9e-11	0.89	0.03	0.97	FALSE
12	YFS	Blood	SHKBP1	0.51	0.09	enet	92	0.27	1.6e-88	-6.8	-6.5	7.5e-11	0.56	0.02	0.98	FALSE
6	GTEx	Cells Transformed fibroblasts	LTBP4	0.12	0.10	lasso	2	0.08	2.0e-06	-6.4	6.5	7.9e-11	-0.42	0.20	0.80	FALSE
4	GTEx	Adipose Visceral Omentum	C19orf54	0.19	0.03	enet	29	0.06	5.8e-04	-5.3	6.1	8.9e-10	0.23	0.37	0.06	FALSE
3	GTEx	Adipose Visceral Omentum	ITPKC	0.12	0.07	enet	13	0.05	8.1e-04	4.9	5.8	6.7e-09	0.20	0.61	0.02	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RAB4B	0.18	0.10	lasso	5	0.11	1.2e-06	-5.6	5.5	4.3e-08	0.12	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BLVRB	0.04	0.00	bslmm	378	0.01	1.8e-02	2.6	5.4	7.2e-08	-0.28	0.18	0.10	FALSE
5	GTEx	Brain Cerebellum	SHKBP1	0.25	0.02	lasso	10	0.06	9.1e-03	4.9	5.4	7.3e-08	0.05	0.06	0.06	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB4B	0.06	0.03	lasso	4	0.04	1.1e-05	-5.5	5.2	2.5e-07	0.07	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	SHKBP1	0.08	0.00	blup	50	0.02	1.5e-02	-6.4	-5.2	2.6e-07	0.32	0.02	0.14	FALSE