[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr19:40,259,342-42,504,505

Best TWAS P=1.49e-15 · Best GWAS P=6.52e-13 conditioned to 0.0842

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BLVRB 0.04 0.00 bslmm 378 0.01 1.8e-02 2.6 5.4 7.2e-08 -0.28 0.18 0.10 FALSE
2 CommonMind Brain Pre-frontal Cortex LTBP4 0.09 0.05 lasso 9 0.04 3.9e-06 -7.2 7.1 1.3e-12 -0.99 0.01 0.99 FALSE
3 GTEx Adipose Visceral Omentum ITPKC 0.12 0.07 enet 13 0.05 8.1e-04 4.9 5.8 6.7e-09 0.20 0.61 0.02 FALSE
4 GTEx Adipose Visceral Omentum C19orf54 0.19 0.03 enet 29 0.06 5.8e-04 -5.3 6.1 8.9e-10 0.23 0.37 0.06 FALSE
5 GTEx Brain Cerebellum SHKBP1 0.25 0.02 lasso 10 0.06 9.1e-03 4.9 5.4 7.3e-08 0.05 0.06 0.06 FALSE
6 GTEx Cells Transformed fibroblasts LTBP4 0.12 0.10 lasso 2 0.08 2.0e-06 -6.4 6.5 7.9e-11 -0.42 0.20 0.80 FALSE
7 GTEx Lung SHKBP1 0.12 0.12 enet 20 0.09 1.8e-07 -6.7 -7.1 1.6e-12 0.86 0.02 0.98 FALSE
8 GTEx Muscle Skeletal ITPKC 0.10 0.07 enet 24 0.05 4.2e-06 -4.1 6.3 2.4e-10 -0.07 0.96 0.00 TRUE
9 GTEx Skin Sun Exposed Lower leg HNRNPUL1 0.09 0.01 lasso 6 0.01 6.8e-02 -5.5 -6.8 9.5e-12 -0.12 0.01 0.85 TRUE
10 GTEx Whole Blood SHKBP1 0.12 0.09 lasso 3 0.07 3.7e-07 -6.7 -6.7 2.9e-11 0.89 0.03 0.97 FALSE
11 NTR Blood SHKBP1 0.05 0.04 enet 18 0.04 3.1e-13 -6.7 -8.0 1.5e-15 0.81 0.03 0.97 TRUE
12 YFS Blood SHKBP1 0.51 0.09 enet 92 0.27 1.6e-88 -6.8 -6.5 7.5e-11 0.56 0.02 0.98 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma LTBP4 0.01 0.00 blup 54 0.01 2.0e-02 -6.5 7.3 3.5e-13 -0.86 0.02 0.54 FALSE
14 The Cancer Genome Atlas Colon Adenocarcinoma SHKBP1 0.08 0.00 blup 50 0.02 1.5e-02 -6.4 -5.2 2.6e-07 0.32 0.02 0.14 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CYP2B7P1 0.20 0.03 blup 56 0.07 4.7e-08 2.2 5.3 1.4e-07 0.05 0.08 0.07 TRUE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB4B 0.10 0.07 lasso 5 0.08 4.2e-09 -5.6 6.3 2.9e-10 0.10 0.00 1.00 TRUE
17 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RAB4B 0.18 0.10 lasso 5 0.11 1.2e-06 -5.6 5.5 4.3e-08 0.12 0.00 1.00 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma RAB4B 0.06 0.03 lasso 4 0.04 1.1e-05 -5.5 5.2 2.5e-07 0.07 0.01 0.99 FALSE