Best TWAS P=1.49e-15 · Best GWAS P=6.52e-13 conditioned to 0.0842
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BLVRB | 0.04 | 0.00 | bslmm | 378 | 0.01 | 1.8e-02 | 2.6 | 5.4 | 7.2e-08 | -0.28 | 0.18 | 0.10 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LTBP4 | 0.09 | 0.05 | lasso | 9 | 0.04 | 3.9e-06 | -7.2 | 7.1 | 1.3e-12 | -0.99 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | ITPKC | 0.12 | 0.07 | enet | 13 | 0.05 | 8.1e-04 | 4.9 | 5.8 | 6.7e-09 | 0.20 | 0.61 | 0.02 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | C19orf54 | 0.19 | 0.03 | enet | 29 | 0.06 | 5.8e-04 | -5.3 | 6.1 | 8.9e-10 | 0.23 | 0.37 | 0.06 | FALSE |
| 5 | GTEx | Brain Cerebellum | SHKBP1 | 0.25 | 0.02 | lasso | 10 | 0.06 | 9.1e-03 | 4.9 | 5.4 | 7.3e-08 | 0.05 | 0.06 | 0.06 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | LTBP4 | 0.12 | 0.10 | lasso | 2 | 0.08 | 2.0e-06 | -6.4 | 6.5 | 7.9e-11 | -0.42 | 0.20 | 0.80 | FALSE |
| 7 | GTEx | Lung | SHKBP1 | 0.12 | 0.12 | enet | 20 | 0.09 | 1.8e-07 | -6.7 | -7.1 | 1.6e-12 | 0.86 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Muscle Skeletal | ITPKC | 0.10 | 0.07 | enet | 24 | 0.05 | 4.2e-06 | -4.1 | 6.3 | 2.4e-10 | -0.07 | 0.96 | 0.00 | TRUE |
| 9 | GTEx | Skin Sun Exposed Lower leg | HNRNPUL1 | 0.09 | 0.01 | lasso | 6 | 0.01 | 6.8e-02 | -5.5 | -6.8 | 9.5e-12 | -0.12 | 0.01 | 0.85 | TRUE |
| 10 | GTEx | Whole Blood | SHKBP1 | 0.12 | 0.09 | lasso | 3 | 0.07 | 3.7e-07 | -6.7 | -6.7 | 2.9e-11 | 0.89 | 0.03 | 0.97 | FALSE |
| 11 | NTR | Blood | SHKBP1 | 0.05 | 0.04 | enet | 18 | 0.04 | 3.1e-13 | -6.7 | -8.0 | 1.5e-15 | 0.81 | 0.03 | 0.97 | TRUE |
| 12 | YFS | Blood | SHKBP1 | 0.51 | 0.09 | enet | 92 | 0.27 | 1.6e-88 | -6.8 | -6.5 | 7.5e-11 | 0.56 | 0.02 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LTBP4 | 0.01 | 0.00 | blup | 54 | 0.01 | 2.0e-02 | -6.5 | 7.3 | 3.5e-13 | -0.86 | 0.02 | 0.54 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | SHKBP1 | 0.08 | 0.00 | blup | 50 | 0.02 | 1.5e-02 | -6.4 | -5.2 | 2.6e-07 | 0.32 | 0.02 | 0.14 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CYP2B7P1 | 0.20 | 0.03 | blup | 56 | 0.07 | 4.7e-08 | 2.2 | 5.3 | 1.4e-07 | 0.05 | 0.08 | 0.07 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAB4B | 0.10 | 0.07 | lasso | 5 | 0.08 | 4.2e-09 | -5.6 | 6.3 | 2.9e-10 | 0.10 | 0.00 | 1.00 | TRUE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RAB4B | 0.18 | 0.10 | lasso | 5 | 0.11 | 1.2e-06 | -5.6 | 5.5 | 4.3e-08 | 0.12 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAB4B | 0.06 | 0.03 | lasso | 4 | 0.04 | 1.1e-05 | -5.5 | 5.2 | 2.5e-07 | 0.07 | 0.01 | 0.99 | FALSE |