TWAS hub - TMUB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0502	0.0242	0.0210	0.008	0.009	0.012	0.013	0.008	0.029	0.022	0.0089	0.0072	0.0260
2	TCGA	Colon Adenocarcinoma	0.0650	0.0350	0.0055	0.023	0.027	0.035	NA	0.030	0.016	0.010	0.0039	NA	0.0074

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Allergy or Eczema	7.4	19.5	21.5	-4.6	4.2
Financial situation satisfaction	6.7	8.4	9.8	-3.1	2.6
Time employed in main current job	5.3	6.1	7.2	-2.2	2.7
Hair/balding pattern: Pattern 3	5.1	7.6	8.8	2.5	-3.0
Leg fat-free mass (left)	5.0	26.4	33.5	-5.8	4.4
Leg predicted mass (left)	5.0	26.6	34.0	-5.8	4.4
Number of full sisters	4.9	6.0	8.4	-2.9	1.9
Leg fat-free mass (right)	4.8	25.6	33.5	-5.8	4.2
Leg predicted mass (right)	4.7	25.0	32.5	-5.7	4.2
Lung FVC	4.1	20.7	35.9	2.3	-6.0
Hayfever, allergic rhinitis or eczema	4.1	8.8	11.0	-2.6	3.3
Basal metabolic rate	4.1	22.7	30.6	-5.5	3.9
Whole body fat-free mass	4.0	22.8	31.1	-5.6	3.8
Weight	3.9	18.9	22.2	-4.7	4.0
Whole body water mass	3.9	22.3	30.5	-5.5	3.8
Allergy	3.5	8.1	11.6	2.1	-3.4
Arm predicted mass (left)	3.5	17.8	24.5	-5.0	3.3
Lung FEV1/FVC ratio	3.4	17.2	30.0	-2.1	5.5
Arm predicted mass (right)	3.3	16.7	21.2	-4.6	3.5
Mother’s age at death	3.3	4.2	8.3	-0.2	2.9
Arm fat-free mass (right)	3.2	16.4	20.5	-4.5	3.5
Arm fat-free mass (left)	3.1	15.5	22.4	-4.7	2.9
Trunk fat-free mass	3.0	17.2	25.1	-5.0	3.0
Trunk predicted mass	3.0	17.2	25.0	-5.0	3.1
Ever had bowel cancer screening	3.0	3.5	4.6	2.1	-1.6
Ever taken oral contraceptive pill	3.0	3.3	4.2	-2.1	1.6
Health satisfaction	2.9	3.8	6.0	-1.3	2.4
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	5.6	2.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	6.2	-0.6	2.5
Trunk fat mass	2.7	11.4	12.1	-3.3	3.5
Knee pain experienced in last month	2.7	4.1	7.8	-0.7	2.8
Eye problems/disorders: Glaucoma	2.7	3.2	3.9	-2.0	1.6
Hearing difficulty/problems: Yes	2.6	4.0	6.6	1.1	2.6
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.5	7.5	-2.7	1.8
Rheumatoid Arthritis	2.5	3.4	4.8	2.2	-1.4
Comparative height size at age 10	2.5	13.9	19.8	-4.5	2.8
Sitting height	2.4	17.1	17.5	-4.2	4.1
Major Depression (MDD)	2.3	2.7	5.5	2.3	0.0
Falls in the last year	2.3	3.1	6.2	-0.1	2.5
Medication: Omeprazole	2.3	2.7	3.7	-1.3	1.9
Whole body fat mass	2.3	9.8	10.4	-3.2	3.0
Diabetes (mother)	2.2	2.8	5.4	-2.3	0.5
Waist circumference	2.2	8.2	9.9	-2.5	3.1
Standing height	2.2	21.5	28.2	-5.3	3.9
Number of operations (self-reported)	2.2	3.3	4.6	-1.4	2.1
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	3.8	-1.2	2.0
Mouth/teeth dental problems	2.1	3.2	3.8	-1.9	-1.6
Hip circumference	2.1	9.1	10.9	-2.7	3.3
Emphysema/chronic bronchitis	2.1	2.3	3.3	1.2	-1.8
Osteoarthritis (self-reported)	2.1	2.7	5.4	-0.1	2.3
Gout (self-reported)	2.0	2.7	5.0	-2.2	-0.6
Alcohol intake frequency.	2.0	4.6	9.1	-3.0	0.2
Average weekly red wine intake	2.0	2.9	5.5	2.3	-0.6
Handedness (chirality/laterality): Left-handed	2.0	2.4	2.8	-1.4	1.7
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	2.4	-1.3	1.6
Primary Biliary Cirrhosis	1.9	2.7	3.8	1.3	-1.9
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	3.5	-0.8	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	2.5	-1.6	1.3
Tense / ‘highly strung’	1.9	3.2	4.2	2.0	-1.4
Mouth/teeth dental problems: Loose teeth	1.9	2.3	4.5	2.1	-0.2
Suffer from ‘nerves’	1.9	3.1	5.8	2.4	-0.6
Arm fat mass (left)	1.9	7.6	9.2	-3.0	2.5
Impedance of leg (right)	1.8	8.8	11.2	3.3	-2.5
Impedance of leg (left)	1.8	8.6	11.6	3.4	-2.4
Leg fat mass (right)	1.8	6.9	6.9	-2.6	2.6
Chest pain or discomfort	1.8	2.6	3.5	-1.3	1.9
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.4	1.5	-1.4
Medication: Atenolol	1.7	2.1	3.1	1.8	-1.1
Arm fat mass (right)	1.7	7.1	8.8	-3.0	2.3
Hearing aid user	1.7	1.9	3.2	1.8	-0.8
Leg fat mass (left)	1.7	6.7	6.9	-2.6	2.6
Ulcerative Colitis	1.6	2.3	3.8	1.9	0.9
Trunk fat percentage	1.6	6.3	8.6	-2.0	2.9
Prospective memory result	1.6	1.9	3.6	-1.9	0.5
Loud music exposure frequency	1.6	1.8	1.8	-1.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.2	1.0	-1.8
Heart disease (mother)	1.6	2.0	3.0	1.7	-1.0
Neuroticism (2016)	1.5	2.2	4.3	2.1	0.1
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.4	0.2	1.9
Nervous feelings	1.5	2.8	3.6	1.9	-1.4
Depression (self-reported)	1.5	1.7	3.1	0.6	-1.8
Pulse wave Arterial Stiffness index	1.5	1.7	3.3	0.2	1.8
Smoking status: Previous	1.5	2.3	2.4	-1.5	1.5
Mood swings	1.5	2.7	5.3	2.3	-0.3
Asthma	1.4	2.7	4.6	-0.8	2.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.8	0.8	1.7
Neck or shoulder pain in last month	1.4	2.0	2.9	1.7	-1.1
Number of self-reported non-cancer illnesses	1.4	2.5	3.6	-1.2	1.9
Ever depressed for a whole week	1.4	1.7	3.0	-0.7	1.7
Depressed Affect (Nagel 2018)	1.3	2.8	3.8	1.9	-1.4
Height	1.3	25.3	30.5	-5.5	4.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.2	-1.1	1.5
Body mass index (BMI)	1.3	5.4	5.5	-2.3	2.3
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	1.8	1.2	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	2.8	1.7	-1.0
Pulse wave reflection index	1.3	1.6	2.5	-0.8	1.6
Medication: Allopurinol	1.3	1.7	3.3	-1.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.5	-1.6	0.9
Pulse rate	1.2	2.0	3.0	1.0	-1.7
Medication: Cholesterol lowering	1.2	1.8	3.6	1.9	0.3
Coronary Artery Disease (CAD)	1.1	1.3	2.5	1.6	-0.2
Severe depression (siblings)	1.1	1.2	1.4	-1.2	1.0
Medication: Ramipril	1.1	1.4	1.8	1.4	-1.0
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.7	2.2	-0.3
Hair/balding pattern: Pattern 4	1.1	2.7	4.2	-1.1	2.1
Medication: Amlodipine	1.1	1.5	3.0	1.7	-0.3
Family relationship satisfaction	1.1	1.3	1.7	1.0	-1.3
Supplements: Vitamin C	1.1	1.3	2.5	1.6	-0.3
Myopia	1.1	1.6	2.4	-1.5	-0.9
Age at First Birth	1.0	1.4	1.7	-1.3	1.0
Ever had hysterectomy (womb removed)	1.0	1.1	2.0	1.4	-0.5
Fed-up feelings	1.0	1.8	3.5	0.4	-1.9
Supplements: Glucosamine	1.0	1.3	1.7	1.3	-0.9
Body fat percentage	1.0	3.9	5.4	-1.5	2.3
Age at first live birth	1.0	1.7	3.3	1.8	-0.2
Pulse wave peak to peak time	1.0	1.1	2.0	-0.6	-1.4
Eye problems/disorders: None of the above	1.0	1.2	1.4	1.0	-1.2
Migraine (self-reported)	1.0	1.2	2.4	0.1	1.6
Age at last live birth	1.0	1.5	2.9	1.7	-0.3
Illnesses of father: Heart disease	1.0	1.4	2.8	0.3	-1.7
Friendships satisfaction	1.0	1.3	1.7	-1.3	0.9
Asthma (self-reported)	1.0	2.1	3.8	-0.6	1.9
Osteoporosis (self-reported)	1.0	1.3	2.6	0.1	-1.6
Medication: Gliclazide	1.0	1.2	2.2	-0.4	-1.5
Miserableness	1.0	1.8	3.0	1.7	-0.8
Worry (Nagel 2018)	0.9	1.8	2.9	1.7	-0.9
BMI	0.9	5.0	6.2	-1.9	2.5
Maternal smoking around birth	0.9	1.2	2.4	-0.2	-1.6
Qualifications: CSEs or equivalent	0.9	1.2	1.5	0.9	-1.2
Qualifications: None of the above	0.9	1.9	3.0	0.9	-1.7
Worry too long after embarrassment	0.9	1.5	2.8	-1.7	-0.5
Irritable Bowel Disease (IBD)	0.8	1.8	2.5	1.1	1.6
Respiratory disease	0.8	1.8	3.1	-1.8	0.6
Average weekly spirits intake	0.8	0.9	1.8	1.4	0.3
Diabetes (father)	0.8	1.0	1.9	1.4	-0.4
Townsend deprivation index at recruitment	0.8	1.1	1.6	-1.3	-0.7
Stomach or abdominal pain in last month	0.8	1.0	1.2	1.1	1.0
Chronic bronchitis/emphysema (father)	0.8	1.0	1.0	-1.0	1.0
Past tobacco smoking	0.8	1.5	1.8	1.4	-1.1
Forced vital capacity (FVC)	0.8	3.1	3.8	-1.6	-2.0
Pain all over the body in last month	0.8	0.9	1.8	-1.3	0.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-1.4	-0.1
Arm fat percentage (left)	0.8	3.2	3.7	-1.6	1.9
Loneliness, isolation	0.8	1.1	2.1	-0.1	1.5
Long-standing illness, disability or infirmity	0.8	1.2	2.3	0.5	1.5
Mineral and other dietary supplements	0.8	1.1	1.5	-1.2	0.9
Medication: Atorvastatin	0.8	1.0	1.5	1.2	-0.8
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.6	1.3	-0.6
Cholesterol lowering medication	0.8	1.1	1.5	0.9	-1.2
Impedance of whole body	0.8	4.2	6.7	2.6	-1.3
Alzheimer’s Disease (in father)	0.7	0.8	1.4	-0.3	-1.2
Ulcerative Colitis (UC)	0.7	1.3	1.5	1.1	1.2
Mean Putamen Volume	0.7	0.8	1.3	-1.1	0.6
HDL Cholesterol	0.7	1.2	1.7	1.3	-0.8
LDL Cholesterol	0.7	1.1	1.3	-1.0	-1.1
Blood Red Count	0.7	6.5	12.8	0.4	3.6
Relative age of first facial hair	0.7	1.3	2.6	-0.3	1.6
Supplements: Zinc	0.7	0.8	1.0	-1.0	0.7
Age when periods started (menarche)	0.7	1.8	3.4	-0.3	1.9
Neuroticism score	0.7	1.4	2.0	1.4	-0.9
Number of live births	0.7	1.0	2.0	0.1	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.5	-2.1	-0.3
Blood clot in the leg (DVT)	0.7	1.0	1.9	0.1	1.4
Forced vital capacity (FVC), Best measure	0.7	2.6	4.2	-0.9	-2.1
Bipolar Disorder or Schizophrenia	0.6	1.4	2.5	1.6	0.6
Neuroticism (Nagel 2018)	0.6	1.4	2.1	1.4	-0.8
Bipolar Disorder (2011)	0.6	0.6	1.1	1.1	0.0
Crohns Disease (2012)	0.6	1.0	1.5	1.2	0.6
Triglycerides	0.6	1.0	1.7	1.3	-0.5
Blood Eosinophil Count	0.6	4.7	7.7	-2.8	1.4
Hand grip strength (left)	0.6	1.6	3.0	-0.5	-1.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	0.8	-0.9	0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	1.2	0.8	1.1
Medication: Lansoprazole	0.6	0.6	1.2	-0.2	1.1
Birth weight of first child	0.6	1.0	1.4	-1.2	-0.8
Glaucoma (self-reported)	0.6	0.7	1.3	-1.1	0.3
Leg pain on walking	0.6	0.7	1.3	-0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.6	-0.3	-1.6
Medication: Bendroflumethiazide	0.6	0.9	1.7	-0.3	1.3
Irritability	0.6	1.0	1.8	1.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	0.3	1.2
Bipolar Disorder (2018)	0.5	0.8	1.5	1.2	-0.2
Schizophrenia (2018)	0.5	1.0	1.1	1.1	0.9
Alzheimer’s Disease (in mother)	0.5	0.5	0.6	0.7	0.8
Fasting Glucose	0.5	0.6	0.6	-0.8	0.8
Systolic Blood Pressure	0.5	2.6	3.6	1.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	-0.3	1.0
Relative age voice broke	0.5	0.8	1.4	-0.5	1.2
Multivitamins +/- minerals	0.5	0.6	0.8	0.9	-0.6
Hair/balding pattern: Pattern 2	0.5	0.7	0.7	-0.8	0.8
Arm fat percentage (right)	0.5	1.9	2.0	-1.4	1.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.1	-1.8	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	1.1	0.3
Medication: Aspirin	0.5	0.6	1.2	1.1	-0.0
Qualifications: nursing, teaching	0.5	0.8	0.9	0.9	-0.9
Breast cancer (self-reported)	0.5	0.6	1.2	1.1	0.3
Medication: Aspirin	0.5	0.7	1.3	1.1	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-0.5	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.7	0.8	0.8	0.9
Medication: Lisinopril	0.5	0.7	1.0	-1.0	0.6
Alcohol drinker status: Never	0.5	0.6	1.0	-1.0	0.4
Ever smoked	0.5	0.8	1.4	-1.2	0.5
Risk taking	0.5	0.7	1.2	0.4	-1.1
Basal cell carcinoma (self-reported)	0.5	0.6	0.7	-0.8	0.8
Crohns Disease (2017)	0.4	0.9	1.6	0.5	1.3
Schizophrenia (2014)	0.4	1.0	1.0	1.0	1.0
Heel T-Score	0.4	3.1	3.2	1.8	-1.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.1	-1.0	0.6
Neuroticism	0.4	1.0	1.3	1.1	-0.9
Chronotype (morning person)	0.4	0.9	1.6	0.4	-1.3
Vitamin and mineral supplements	0.4	0.6	0.9	-0.9	0.6
Average weekly fortified wine intake	0.4	0.4	0.8	0.9	0.1
Fluid intelligence score	0.4	0.9	1.8	1.3	0.1
Illnesses of siblings	0.4	0.6	1.2	1.1	0.1
Lung cancer (father)	0.4	0.4	0.8	-0.2	0.9
Exposure to tobacco smoke outside home	0.4	0.5	0.7	0.8	-0.6
Commuting to job workplace: Walk	0.4	0.5	0.8	0.9	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.3	1.1	0.4
Smoking status: Current	0.4	0.6	1.1	-0.3	-1.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.6	-0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	0.8	0.9	-0.4
Ovarian Cancer	0.3	0.4	0.5	0.7	0.5
Blood Platelet Count	0.3	3.0	3.2	-1.7	-1.8
Smoking Status	0.3	0.8	1.6	-1.2	0.2
Cardiovascular Disease	0.3	0.9	1.5	0.6	-1.2
Hair Pigment	0.3	7.5	9.8	-2.3	3.1
Sensitivity / hurt feelings	0.3	0.4	0.6	-0.6	-0.8
Pack years adult smoking proportion	0.3	0.4	0.4	-0.6	-0.7
Current tobacco smoking	0.3	0.5	0.9	-0.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.8	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	0.5	0.7
Serious illness, injury or assault to yourself	0.3	0.4	0.6	-0.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Medication: Levothyroxine sodium	0.3	0.5	0.9	0.9	0.2
Alcohol usually taken with meals	0.3	0.5	0.6	-0.5	0.8
Financial difficulties in last 2 years	0.3	0.5	0.5	-0.7	0.7
Heart attack	0.3	0.3	0.6	0.8	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.9	-0.3
Happiness	0.3	0.4	0.5	-0.7	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.8	-0.3
Impedance of arm (left)	0.3	1.2	2.2	1.5	-0.5
Exposure to tobacco smoke at home	0.3	0.4	0.5	0.7	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	0.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.6	-0.8	-0.6
Leg fat percentage (right)	0.3	0.9	1.6	-0.5	1.3
Hypertension (Self-reported)	0.3	0.9	1.1	0.8	-1.1
Back pain experienced in last month	0.3	0.5	0.7	0.8	-0.5
Medication: Paracetamol	0.3	0.5	0.6	0.8	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.9	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.3	-1.1	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.8	-0.5
Heart disease (siblings)	0.3	0.4	0.4	0.5	0.7
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.1	0.9
Depression (Nagel 2018)	0.2	0.3	0.4	0.3	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	0.9	-0.4
Breast Cancer	0.2	0.5	0.9	-0.3	-0.9
Lupus	0.2	0.4	0.5	0.7	-0.5
Tanning	0.2	2.0	2.6	-1.2	1.6
Number of treatments/medications taken	0.2	0.4	0.7	-0.3	0.9
Medication: Metformin	0.2	0.3	0.6	-0.8	-0.0
Taking other prescription medications	0.2	0.2	0.4	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.5	-0.7	0.7
High blood pressure	0.2	0.6	1.0	0.5	-1.0
Number of incorrect matches in round	0.2	0.3	0.4	-0.3	-0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.6	0.6
Medication: Simvastatin	0.2	0.3	0.5	0.7	0.4
Impedance of arm (right)	0.2	1.1	1.7	1.3	-0.8
Father’s age at death	0.2	0.2	0.4	-0.1	0.6
Worrier / anxious feelings	0.2	0.4	0.6	0.5	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.4	-0.3	0.6
Illnesses of mother	0.2	0.2	0.2	-0.5	-0.4
Length of working week for main job	0.2	0.2	0.4	-0.6	0.2
Breastfed as a baby	0.2	0.2	0.3	-0.6	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.1	0.6
High blood pressure (siblings)	0.2	0.2	0.4	-0.7	-0.1
Comparative body size at age 10	0.2	0.6	1.2	1.1	-0.2
Qualifications: College or University degree	0.2	0.7	1.3	0.3	1.1
Medication: Blood pressure	0.2	0.3	0.4	-0.4	0.6
Medication: Ibuprofen	0.2	0.2	0.3	-0.5	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.6	-0.1
Overall health rating	0.2	0.4	0.5	-0.7	0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.3	-0.5	0.5
Wears glasses or contact lenses	0.2	0.3	0.4	-0.6	0.4
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.0	-0.7
Medication: Blood pressure	0.2	0.4	0.8	0.9	-0.2
High cholesterol (Self-reported)	0.2	0.4	0.4	0.6	-0.6
Leg fat percentage (left)	0.2	0.8	1.4	-0.5	1.2
Age started oral contraceptive pill	0.2	0.2	0.5	-0.7	0.1
Pain experienced in last month	0.2	0.3	0.5	-0.7	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.7	0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.2	-0.4	0.4
Reaction Time	0.1	0.1	0.1	0.2	-0.4
Prostate Cancer	0.1	0.1	0.2	0.5	0.0
Hypothyroidism (self reported)	0.1	0.1	0.2	0.4	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.3	-0.3
Hand grip strength (right)	0.1	0.2	0.4	-0.6	-0.1
Had menopause	0.1	0.1	0.1	0.4	0.4
Had other major operations	0.1	0.1	0.1	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.2	0.6
Diabetes (self-reported)	0.1	0.2	0.2	-0.5	0.4
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.7	0.0
Medication: Paracetamol	0.1	0.1	0.1	0.4	-0.2
Headache pain in last month	0.1	0.2	0.3	0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.5	0.3
Birth weight	0.1	0.2	0.4	-0.2	0.6
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.2	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.0	-0.6
Mean time to correctly identify matches	0.1	0.1	0.2	0.3	0.4
Had major operations	0.1	0.1	0.1	-0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.5	-0.0
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.5	0.1
Guilty feelings	0.1	0.2	0.2	-0.4	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.0	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.5	-0.1
Supplements: Calcium	0.1	0.1	0.2	-0.4	0.3
Pack years of smoking	0.1	0.2	0.3	-0.3	-0.6
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.3	-0.1
HbA1C	0.0	0.0	0.1	-0.2	0.2
Blood White Count	0.0	0.0	0.1	-0.3	-0.0
Waist Hip Ratio (WHR)	0.0	0.1	0.2	0.3	-0.4
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.2	-0.0
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.5	-0.3
Angina	0.0	0.0	0.0	0.1	0.0
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.2	-0.0
Medication: Co-codamol	0.0	0.0	0.1	-0.3	-0.1
High blood pressure (mother)	0.0	0.0	0.0	-0.2	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.2	0.2
Noisy workplace	0.0	0.0	0.0	0.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	0.1	0.1
Number of full brothers	0.0	0.1	0.1	-0.3	0.2
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	-0.4	0.1
Number of children fathered	0.0	0.0	0.1	-0.1	0.3
Angina (self-reported)	0.0	0.0	0.0	0.1	-0.1
Pulse rate, automated reading	0.0	0.1	0.2	-0.2	0.4
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.1	0.2
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.0	0.1
Medication for cholesterol	0.0	0.0	0.1	-0.1	-0.3
Illnesses of father: High blood pressure	0.0	0.0	0.0	-0.2	0.1
Average weekly beer plus cider intake	0.0	0.1	0.1	-0.3	-0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.0	-0.4
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.2	0.2

Hub : Genes

TMUB1

Models

Trait associations