TWAS hub - BMF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0439	0.0236	0.0290	0.004	0.004	0.014	0.005	0.001	0.0730	6.9e-02	2.9e-03	5.5e-02	1.8e-01
2	YFS	Blood	0.0562	0.0185	0.0004	0.007	0.016	0.016	0.018	0.019	0.0015	4.1e-06	5.1e-06	8.4e-07	6.4e-07
3	TCGA	Brain Lower Grade Glioma	0.0329	0.0192	0.0100	-0.002	0.018	0.006	NA	-0.001	0.8600	3.4e-03	6.6e-02	NA	3.9e-01
4	TCGA	Thyroid Carcinoma	0.1050	0.0500	0.0065	0.005	0.020	0.016	NA	0.006	0.1000	4.3e-03	9.1e-03	NA	7.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Ever had stillbirth, spontaneous miscarriage or termination	5.3	5.6	6.4	2.0	2.5	-2.5	2.4
Lung FEV1/FVC ratio	4.2	21.4	40.7	6.4	4.1	-4.3	3.1
Lung FVC	3.5	17.7	41.5	-6.4	-3.1	3.6	-2.6
Ever had bowel cancer screening	3.4	4.0	5.9	0.1	2.3	-2.2	2.4
Pulse rate, automated reading	3.2	10.4	20.9	0.3	4.3	-1.4	4.6
Forced vital capacity (FVC)	3.1	11.8	22.2	-4.7	-3.3	2.8	-2.5
Illnesses of father: High blood pressure	3.1	3.8	8.9	-0.9	-1.9	1.4	-3.0
Hair/balding pattern: Pattern 3	3.0	4.5	7.5	1.6	2.7	-1.9	2.1
Medication: Atorvastatin	2.9	3.6	8.0	0.7	2.8	-1.4	2.0
HbA1C	2.8	3.2	8.0	2.8	-1.0	1.1	-1.6
Pulse rate	2.7	4.6	10.3	0.4	3.2	-0.3	2.8
Length of working week for main job	2.7	3.0	9.3	-1.0	-3.0	1.4	-0.1
Tinnitus: Yes, now most or all of the time	2.6	3.1	7.3	-2.7	-1.8	0.7	1.1
Forced vital capacity (FVC), Best measure	2.5	9.3	22.7	-4.8	-3.2	1.4	-1.5
Pain all over the body in last month	2.4	2.6	5.2	-1.6	-2.3	1.5	-0.7
Medication: Amlodipine	2.4	3.4	9.3	0.8	1.7	-0.6	3.1
Type 2 Diabetes (T2D) (2018)	2.3	4.3	12.4	3.5	2.2	0.1	0.2
Osteoarthritis (self-reported)	2.3	2.9	8.5	-1.4	-2.9	1.1	-0.2
Supplements: Calcium	2.3	2.5	9.0	-3.0	-0.9	-0.4	0.3
Worry (Nagel 2018)	2.2	4.5	10.8	2.3	3.3	-1.0	1.0
Triglycerides	2.2	3.6	6.7	2.6	1.6	-2.2	0.7
Headache pain in last month	2.2	3.8	9.0	-1.1	1.1	-3.0	1.9
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	4.4	-2.1	-2.0	0.1	-1.4
Alzheimer’s Disease (in father)	2.1	2.2	6.0	0.1	1.2	-1.3	2.4
Illnesses of mother	2.1	2.6	8.6	-1.1	-0.8	0.0	-2.9
Exposure to tobacco smoke at home	2.1	2.4	3.9	0.8	-1.5	2.0	-1.7
Nervous feelings	2.0	3.7	6.6	1.2	2.6	-2.0	1.8
Mouth/teeth dental problems: Dentures	2.0	3.4	7.1	0.8	2.4	-0.3	2.7
Medication: Paracetamol	2.0	3.3	6.7	-2.5	-2.6	-0.3	-0.3
Qualifications: CSEs or equivalent	1.8	2.4	6.3	-0.6	-1.5	0.8	-2.5
Medication: Atenolol	1.8	2.2	6.2	2.5	1.6	-0.2	0.3
Diabetes (self-reported)	1.8	2.8	9.4	3.1	1.3	-0.0	0.1
Suffer from ‘nerves’	1.8	2.8	4.9	0.2	2.2	-1.8	1.8
Osteoporosis (self-reported)	1.8	2.2	4.5	-0.0	1.4	-1.5	2.1
Medication: Paracetamol	1.8	2.8	10.1	-0.8	-3.2	0.5	-0.6
Ovarian Cancer	1.7	2.2	6.1	-2.5	-0.3	1.6	0.4
Average weekly fortified wine intake	1.7	2.0	4.0	0.7	-2.0	1.0	-1.6
Financial difficulties in last 2 years	1.7	2.2	4.5	-2.1	-1.8	0.9	-0.7
Mean Putamen Volume	1.6	1.9	4.0	0.0	1.8	-2.0	0.4
Diabetes (father)	1.6	1.9	5.5	2.4	1.2	-0.6	0.6
Townsend deprivation index at recruitment	1.6	2.3	4.4	-1.7	-0.8	1.2	-2.1
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.8	1.9	0.8	0.9	-1.4
Hair/balding pattern: Pattern 4	1.6	4.0	10.8	1.3	0.5	1.8	-3.3
Number of full sisters	1.6	1.9	4.4	-0.3	-2.1	0.2	-1.8
Breast Cancer	1.5	3.7	7.9	-0.6	0.6	2.8	-2.4
Blood Red Count	1.5	14.3	30.8	-1.1	-5.5	3.0	-4.0
Medication: Metformin	1.5	2.1	5.5	2.4	1.6	0.6	0.4
Noisy workplace	1.5	1.9	2.6	-1.1	-1.6	1.6	-1.1
Birth weight	1.5	3.2	10.4	-3.2	-0.3	-0.7	1.4
Comparative body size at age 10	1.5	4.2	7.8	-2.8	-1.5	-0.5	2.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.0	1.6	0.1	-0.5	2.0
Diabetes diagnosed by doctor	1.5	2.5	8.2	2.9	1.0	-0.7	0.4
Alcohol usually taken with meals	1.4	2.3	4.9	-1.0	1.4	-1.2	2.2
Birth weight of first child	1.4	2.5	6.7	-1.4	1.0	-0.3	2.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.2	1.4	-0.9	-0.5	-2.0
Back pain experienced in last month	1.4	2.1	5.9	0.2	-2.4	-1.6	-0.1
Fractured/broken bones in last 5 years	1.4	1.8	6.8	0.3	-2.6	0.7	0.0
Ever depressed for a whole week	1.4	1.8	3.0	-1.1	-1.7	-0.6	-1.6
Number of incorrect matches in round	1.3	2.1	3.9	1.6	-0.1	-1.3	2.0
Hair/balding pattern: Pattern 2	1.3	1.6	4.4	-2.1	-1.4	0.1	-0.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.3	-1.8	0.4	1.4	-1.2
Medication: Cholesterol lowering	1.3	1.9	5.5	2.4	1.0	-0.5	1.0
Medication: Aspirin	1.3	1.7	4.9	2.2	0.2	-1.3	0.6
Illnesses of siblings: Diabetes	1.3	1.6	3.9	1.3	0.1	-0.9	2.0
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.9	-0.4	2.2	-1.4	2.1
Number of treatments/medications taken	1.2	2.2	4.5	0.7	0.6	-1.9	2.1
Hearing difficulty/problems with background noise	1.2	1.8	4.1	0.6	1.7	-0.4	2.0
Hip circumference	1.2	5.3	11.8	-3.4	-2.4	1.3	-1.3
Father’s age at death	1.2	1.6	2.5	-0.3	1.6	1.6	-1.1
Pulse wave reflection index	1.2	1.4	2.4	-1.4	-1.2	-0.1	-1.6
Glaucoma (self-reported)	1.2	1.4	4.9	2.2	0.6	0.6	0.2
Number of full brothers	1.2	1.5	2.9	-0.5	-1.4	1.7	-0.8
Medication: Aspirin	1.2	1.6	5.7	2.4	-0.2	-0.8	0.3
Unable to work because of sickness or disability	1.2	1.6	3.7	-1.9	-1.1	0.2	1.2
Angina	1.1	1.4	2.5	1.4	1.6	0.3	-0.9
Severe depression (siblings)	1.1	1.2	2.8	-1.3	0.3	-0.4	-1.7
Sitting height	1.1	7.7	11.6	-3.1	-2.9	1.1	-3.4
Time employed in main current job	1.1	1.3	2.2	0.8	0.7	-1.3	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.0	-1.4	-2.0	-0.2	-1.0
Happiness	1.1	1.4	2.9	-1.2	1.7	-1.1	-0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.7	-2.2	-0.5	-0.9	0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.5	0.4	0.3	-1.6	1.6
Medication for pain relief, constipation, heartburn	1.1	1.8	4.1	-0.2	1.2	2.0	-1.3
Neck or shoulder pain in last month	1.1	1.5	4.8	1.0	-0.2	-2.2	0.5
Angina (self-reported)	1.1	1.4	2.8	1.4	1.7	-0.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.8	2.2	0.1	-0.2	-0.6
Knee pain experienced in last month	1.1	1.7	3.5	0.6	-1.5	1.9	-0.9
Long-standing illness, disability or infirmity	1.1	1.6	3.3	1.8	1.7	0.4	0.0
Age at First Birth	1.0	1.5	4.9	0.9	2.2	-0.1	0.3
Hypothyroidism (self reported)	1.0	2.3	7.9	0.9	2.8	0.7	0.3
Relative age voice broke	1.0	1.5	2.5	1.4	1.6	1.2	0.6
Leg predicted mass (left)	1.0	5.0	10.9	-3.3	-2.5	0.7	-1.6
Number of live births	1.0	1.3	1.7	0.8	1.3	-1.2	1.3
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	5.2	-2.3	-2.1	1.3	-1.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	4.2	-1.0	-2.0	-0.1	1.0
Age at last live birth	1.0	1.4	3.2	0.3	1.5	-1.8	0.6
Leg fat-free mass (right)	1.0	5.1	11.1	-3.3	-2.5	0.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.9	-2.2	-0.3	1.7	-0.8
Basal metabolic rate	1.0	5.3	11.1	-3.3	-2.7	0.7	-1.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.5	-0.1	1.9	-0.2	0.9
Crohns Disease (2012)	0.9	1.5	2.6	0.5	1.4	-1.6	1.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.7	-0.7	-0.1	-1.3	1.6
Vitamin and mineral supplements	0.9	1.2	2.3	-0.0	-1.5	0.6	-1.4
Supplements: Zinc	0.9	1.0	1.9	-1.4	-0.5	0.5	-1.2
Leg fat-free mass (left)	0.9	5.0	10.5	-3.2	-2.6	0.7	-1.6
Weight	0.9	4.6	6.9	-2.6	-2.6	1.1	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.2	1.1	-0.9	1.5	0.3
Breastfed as a baby	0.9	1.1	1.7	-1.3	-1.2	0.7	0.8
Age at first live birth	0.9	1.6	3.5	0.0	1.9	-1.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.2	-1.5	-1.8	0.4	-1.4
Whole body fat-free mass	0.9	4.9	12.1	-3.5	-2.4	0.5	-1.2
Breast cancer (self-reported)	0.9	1.1	1.8	1.1	0.4	1.4	-1.1
Whole body water mass	0.9	5.0	12.3	-3.5	-2.5	0.5	-1.2
Leg predicted mass (right)	0.9	5.1	11.4	-3.4	-2.5	0.4	-1.6
Ever taken oral contraceptive pill	0.9	1.0	1.7	0.6	-0.5	-1.3	1.3
Alcohol drinker status: Never	0.9	1.1	1.8	1.3	0.6	1.1	-1.0
Pack years of smoking	0.9	1.3	1.8	-1.1	-1.1	-1.3	0.9
Primary Biliary Cirrhosis	0.8	1.2	2.2	1.4	-0.7	1.5	-0.3
Rheumatoid Arthritis	0.8	1.2	3.0	0.1	-1.7	-1.3	-0.3
BMI	0.8	4.7	10.8	-3.3	-1.9	1.2	-1.7
Height	0.8	16.0	31.8	-5.6	-3.9	1.8	-3.7
Average weekly spirits intake	0.8	1.0	2.1	-1.0	0.5	-0.7	1.5
Diabetes (mother)	0.8	1.1	4.0	0.2	-0.3	-0.4	2.0
Supplements: Glucosamine	0.8	1.0	3.2	0.8	-0.4	1.8	0.3
Qualifications: None of the above	0.8	1.8	3.7	0.6	-0.8	1.5	-1.9
Medication: Ramipril	0.8	1.0	1.2	1.1	-1.1	0.9	0.9
Medication: Simvastatin	0.8	1.2	3.8	1.9	-0.2	0.8	-0.5
Trunk fat-free mass	0.8	4.5	12.7	-3.6	-2.2	0.3	-0.6
Falls in the last year	0.8	1.1	2.0	-1.4	-0.4	1.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.9	-2.2	-1.9	0.5	-1.0
Trunk predicted mass	0.8	4.5	12.6	-3.5	-2.2	0.3	-0.7
Tense / ‘highly strung’	0.8	1.3	3.3	1.8	1.2	-0.2	-0.7
Comparative height size at age 10	0.8	4.6	11.5	-1.6	-1.7	1.3	-3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.7	1.6	0.2	-0.7	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.5	0.9	0.7	-0.6	1.6
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.0	-2.0	1.3	-0.7	1.6
Body Mass Index (BMI) (2010)	0.7	0.9	2.4	-1.6	-0.6	0.2	0.9
Blood White Count	0.7	5.1	10.1	3.2	1.4	-2.9	0.3
Systolic Blood Pressure	0.7	3.6	8.0	2.8	0.9	2.3	-0.5
Relative age of first facial hair	0.7	1.4	3.8	1.9	0.7	0.7	1.0
Systolic blood pressure, automated reading	0.7	1.9	5.9	2.4	0.5	1.2	0.4
Pack years adult smoking proportion	0.7	1.0	1.4	-1.0	-1.2	-1.1	0.6
Maternal smoking around birth	0.7	1.1	3.0	1.7	1.1	-0.1	0.2
Had menopause	0.7	0.8	1.7	1.1	0.0	-0.7	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.6	-0.6	-1.6	-0.5	-0.2
Standing height	0.7	6.6	14.5	-3.8	-2.4	1.1	-2.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.0	-1.4	-1.1	-0.3	-0.0
Arm fat-free mass (right)	0.7	3.8	6.9	-2.2	-2.6	1.0	-1.5
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.7	0.9	-0.2	1.3
Arm predicted mass (right)	0.7	3.6	6.5	-2.4	-2.6	0.7	-1.3
Supplements: Vitamin C	0.7	0.8	2.4	0.3	0.3	1.5	-0.7
Eye problems/disorders: Cataract	0.7	0.8	1.5	-1.2	-1.1	0.6	-0.3
High cholesterol (Self-reported)	0.7	1.2	1.8	1.3	1.2	-0.1	1.2
Arm predicted mass (left)	0.7	3.6	6.2	-2.5	-2.5	0.4	-1.3
Neuroticism (Nagel 2018)	0.6	1.3	3.3	1.2	1.8	-0.8	-0.1
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	-1.5	-0.2	-0.2	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	1.4	0.6	-0.5	0.2
Heel T-Score	0.6	4.9	9.1	3.0	-0.8	-1.6	-2.7
Chronotype (morning person)	0.6	1.3	3.5	-0.4	0.3	-1.9	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.2	1.5	-0.3	-1.5	-0.9
Stomach or abdominal pain in last month	0.6	0.7	1.5	-0.9	-0.3	-1.2	0.8
Medication: Levothyroxine sodium	0.6	1.0	1.8	1.3	1.1	1.1	0.0
Had other major operations	0.6	0.7	2.1	0.5	-1.4	0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.8	-1.9	0.2	0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.7	0.9	1.9	0.6	0.2
Mean time to correctly identify matches	0.6	1.2	2.1	0.3	1.2	-1.1	1.4
Chest pain or discomfort	0.6	0.9	1.8	0.4	1.3	-0.6	1.2
Had major operations	0.6	0.7	1.6	-0.6	-0.7	-1.3	0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.0	0.7	-0.9	-1.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	1.0	0.7	-0.4	-1.2
Illnesses of father: Heart disease	0.6	0.8	2.6	0.7	1.6	-0.4	-0.3
Loneliness, isolation	0.6	0.8	1.5	-1.0	0.2	0.7	-1.2
Qualifications: nursing, teaching	0.6	0.9	2.1	-0.2	0.1	-1.1	1.5
Hearing aid user	0.6	0.6	2.3	0.3	0.4	1.5	0.1
Mother’s age at death	0.6	0.8	1.3	0.6	1.2	-0.8	0.8
Commuting to job workplace: Public transport	0.6	0.8	1.2	-0.8	-1.1	0.9	0.7
Arm fat-free mass (left)	0.6	3.1	6.3	-2.5	-2.1	0.5	-1.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	0.8	0.8	-1.3	0.5
Impedance of whole body	0.6	3.1	7.0	2.6	1.8	0.4	-1.4
Ulcerative Colitis (UC)	0.5	0.9	2.9	0.1	-0.8	1.7	-0.2
Neuroticism (2016)	0.5	0.7	1.4	1.2	-0.5	0.3	-1.1
Waist Hip Ratio (WHR)	0.5	2.4	2.9	1.6	1.6	-1.7	1.1
Impedance of leg (right)	0.5	2.4	7.1	2.7	1.6	0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.0	-1.0	-0.8	0.8	-0.4
High blood pressure	0.5	1.3	2.8	1.7	-1.2	-0.0	1.0
High blood pressure (mother)	0.5	0.7	2.1	0.8	-0.3	-0.0	1.4
Impedance of leg (left)	0.5	2.5	6.9	2.6	1.7	-0.2	-0.2
Past tobacco smoking	0.5	0.9	1.9	-0.9	-0.8	1.4	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	1.1	-0.7	-0.4	-1.6
Heart attack	0.5	0.6	1.5	0.8	0.6	-1.2	0.3
Fluid intelligence score	0.5	1.1	3.2	-0.5	1.8	-0.4	0.9
Illnesses of siblings	0.5	0.7	2.5	0.0	0.3	0.6	-1.6
Asthma	0.5	1.0	1.4	-1.2	1.1	0.8	1.0
High blood pressure (siblings)	0.5	0.8	1.2	-1.1	-0.4	-0.9	0.9
Number of children fathered	0.5	0.6	1.1	-1.1	-0.6	-0.5	0.7
Emphysema/chronic bronchitis	0.5	0.6	1.1	-1.0	-0.5	-0.2	1.0
Medication: Omeprazole	0.5	0.6	1.3	-0.8	0.7	-1.1	0.3
Heart disease (mother)	0.5	0.7	1.5	-0.2	-1.2	0.2	1.0
Leg pain on walking	0.5	0.6	0.9	0.7	-1.0	0.9	-0.5
Hypertension (Self-reported)	0.5	1.3	3.3	1.8	-0.7	-0.1	1.1
Smoking status: Previous	0.5	0.7	1.1	1.1	1.0	-0.6	-0.4
Friendships satisfaction	0.5	0.6	0.9	-1.0	-0.5	0.6	-0.9
Medication for cholesterol	0.5	0.8	1.6	1.1	0.4	0.6	-1.2
Medication: Gliclazide	0.5	0.6	1.0	1.0	0.6	0.9	-0.3
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	0.5	-0.0	-1.0	1.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	1.4	0.2	0.2	0.4
Medication: Blood pressure	0.5	0.9	3.4	-0.0	0.3	-0.4	1.8
Medication: Bendroflumethiazide	0.5	0.8	1.2	0.4	0.9	1.0	1.1
Number of operations (self-reported)	0.5	0.7	1.1	0.3	-1.0	-1.1	0.7
Average weekly beer plus cider intake	0.5	0.7	1.7	0.7	-0.7	-0.1	-1.3
Heart disease (siblings)	0.5	0.7	1.2	0.7	-1.1	-0.6	0.7
Bipolar Disorder (2018)	0.4	0.7	1.3	0.5	0.7	-0.8	1.1
Schizophrenia (2018)	0.4	0.9	1.3	-0.8	-0.9	0.9	-1.2
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	0.0	0.8	0.9	-0.6
Reaction Time	0.4	0.8	1.3	-0.4	0.7	-1.1	1.0
Fasting Glucose	0.4	0.4	1.1	1.1	0.1	0.8	-0.0
HDL Cholesterol	0.4	0.6	2.0	-0.1	0.7	0.2	1.4
LDL Cholesterol	0.4	0.6	1.6	0.7	-0.3	-1.3	0.6
Blood Eosinophil Count	0.4	2.7	5.5	1.9	2.3	1.2	0.6
Allergy or Eczema	0.4	0.9	1.8	0.1	1.4	-0.2	-1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	1.2	-0.3	-0.1	0.7
Medication for hormone replacement therapy	0.4	0.4	0.7	-0.8	0.6	-0.1	0.8
Trunk fat percentage	0.4	1.6	5.3	0.0	-0.6	0.9	-2.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.2	-0.4	1.1	0.5	-1.5
Multivitamins +/- minerals	0.4	0.5	1.0	-0.1	1.0	-0.6	0.9
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-0.7	-0.6	1.0	-0.5
Trunk fat mass	0.4	1.8	4.2	-1.1	-1.1	0.7	-2.0
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-0.7	-1.1	0.8	-0.2
Depression (self-reported)	0.4	0.5	1.4	-1.2	-0.3	-0.7	-0.1
Medication: Lansoprazole	0.4	0.5	1.1	-0.4	-0.2	1.1	-0.8
Lung cancer (father)	0.4	0.5	1.3	-0.1	-1.1	-0.1	-0.8
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	-1.0	-0.3	-0.5	0.6
Impedance of arm (left)	0.4	1.9	2.9	1.5	1.4	0.7	-1.7
Exposure to tobacco smoke outside home	0.4	0.5	0.6	0.7	0.6	-0.8	0.7
Worry too long after embarrassment	0.4	0.6	1.3	-1.0	0.2	-1.1	0.3
Overall health rating	0.4	0.8	1.6	1.3	0.9	-0.8	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	-0.1	1.1	0.7	-0.2
Mood swings	0.4	0.8	2.7	0.4	0.2	0.3	-1.6
Asthma (self-reported)	0.4	0.9	1.2	-1.1	1.0	0.8	0.7
Average weekly champagne plus white wine intake	0.4	0.6	0.7	0.8	-0.7	0.7	-0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.1	1.0	0.4	-0.9
Irritability	0.4	0.6	1.2	1.1	0.8	-0.9	-0.1
Diastolic blood pressure, automated reading	0.4	1.4	4.6	0.6	-0.3	2.1	-0.6
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.1	-1.8	0.9	0.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.3	0.9	-1.0	-0.3
Pain experienced in last month	0.4	0.7	1.7	-0.5	0.7	1.3	-0.3
Major Depression (MDD)	0.3	0.4	0.9	-0.6	0.9	-0.5	-0.2
Coronary Artery Disease (CAD)	0.3	0.4	1.5	1.2	-0.0	0.2	0.2
Lupus	0.3	0.5	1.0	0.8	1.0	0.3	0.5
Cardiovascular Disease	0.3	1.1	3.8	1.9	-0.4	0.7	0.1
Neuroticism	0.3	0.7	2.1	-0.6	1.4	-0.4	0.2
Hearing difficulty/problems: Yes	0.3	0.4	1.4	0.2	-0.2	1.2	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	-0.8	-0.6	0.1	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.2	0.3	1.0	-0.4
Fed-up feelings	0.3	0.6	1.9	0.2	-0.0	0.7	-1.4
Waist circumference	0.3	1.0	2.3	-1.5	-1.2	0.2	-0.6
Mouth/teeth dental problems	0.3	0.4	1.3	-0.3	-0.3	-0.5	-1.1
Prospective memory result	0.3	0.4	0.7	0.7	-0.8	0.1	-0.5
Arm fat mass (right)	0.3	1.2	1.9	-1.1	-1.2	0.5	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.7	-0.4	-0.9	-0.6
Loud music exposure frequency	0.3	0.3	1.0	-0.4	0.2	-0.5	1.0
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.1	-1.0	-0.5	0.4
Gout (self-reported)	0.3	0.4	1.3	-0.1	-0.5	-0.1	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.8	0.5	0.4	-0.6
Health satisfaction	0.3	0.4	0.5	0.6	0.7	-0.7	-0.6
Shortness of breath walking on level ground	0.3	0.3	0.9	-0.1	-1.0	0.3	-0.6
Migraine (self-reported)	0.3	0.4	1.0	-1.0	-0.6	0.3	-0.0
Medication: Ibuprofen	0.3	0.3	1.3	-0.3	-1.1	-0.2	0.0
Medication: Allopurinol	0.3	0.3	0.9	0.3	0.1	-1.0	0.6
Whole body fat mass	0.3	1.5	2.5	-1.0	-1.3	0.8	-1.6
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	-0.4	-0.5	0.4	0.9
Arm fat mass (left)	0.3	1.2	2.5	-1.0	-1.1	0.5	-1.6
Miserableness	0.3	0.6	1.7	0.2	-0.7	0.3	-1.3
Wears glasses or contact lenses	0.3	0.4	1.3	0.5	0.2	0.1	-1.1
Financial situation satisfaction	0.3	0.4	1.1	-1.1	-0.5	0.4	-0.3
Ever smoked	0.3	0.6	2.0	0.6	0.2	-1.4	-0.3
Myopia	0.3	0.5	1.6	-0.3	-0.5	0.0	-1.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.6	-0.2	0.6	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	0.2	-1.1	-0.4	0.2
Alcohol drinker status: Previous	0.3	0.3	1.0	-0.4	-0.1	-0.2	1.0
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	0.2	0.3	0.7	-0.9
Depression (Nagel 2018)	0.2	0.3	0.6	-0.4	-0.1	0.5	-0.8
Crohns Disease (2017)	0.2	0.4	1.0	0.1	1.0	-0.6	0.7
Ulcerative Colitis	0.2	0.2	0.8	0.9	-0.1	0.4	0.2
Smoking Status	0.2	0.4	0.6	0.5	-0.7	-0.8	0.6
Respiratory disease	0.2	0.5	1.3	0.0	1.2	0.6	0.5
Sensitivity / hurt feelings	0.2	0.4	0.8	0.9	0.6	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.7	-0.7	-0.2	-0.5
Medication: Co-codamol	0.2	0.2	0.3	0.5	0.6	0.6	-0.1
Hand grip strength (right)	0.2	0.5	1.4	-0.7	-0.3	0.4	-1.2
Taking other prescription medications	0.2	0.3	1.1	0.0	0.1	-1.0	0.1
Age when periods started (menarche)	0.2	0.6	1.5	-1.2	-0.7	-0.0	0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.5	-0.1	-0.7	0.3
Body mass index (BMI)	0.2	0.8	1.7	-0.8	-1.3	0.4	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.4	-0.9	-0.2	-0.3
Neuroticism score	0.2	0.5	1.1	0.1	1.0	-0.7	-0.5
Worrier / anxious feelings	0.2	0.3	0.7	-0.2	0.8	-0.3	0.6
Body fat percentage	0.2	0.8	2.5	0.2	-0.4	0.6	-1.6
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.5	0.8	-0.5	0.4
Pulse wave peak to peak time	0.2	0.2	0.3	0.6	0.1	0.5	-0.3
Qualifications: College or University degree	0.2	0.5	0.9	-0.9	1.0	-0.2	0.4
Leg fat mass (right)	0.2	0.9	1.6	-0.9	-1.3	0.7	-0.9
Family relationship satisfaction	0.2	0.2	0.8	-0.9	0.3	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	0.0	0.2	-0.8	0.7
Commuting to job workplace: Walk	0.2	0.2	0.6	0.4	-0.2	0.8	0.3
Mineral and other dietary supplements	0.2	0.3	0.8	-0.5	-0.2	-0.4	-0.9
Guilty feelings	0.2	0.3	1.2	0.1	0.1	0.3	-1.1
Risk taking	0.2	0.3	0.6	-0.8	0.5	-0.3	0.6
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.4	-0.3	0.6	0.6
Leg fat mass (left)	0.2	0.9	1.4	-1.0	-1.2	0.7	-0.9
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.1	0.7	0.1	-0.2
Irritable Bowel Disease (IBD)	0.1	0.1	0.5	0.3	-0.1	0.7	-0.0
Prostate Cancer	0.1	0.1	0.1	-0.4	-0.3	0.1	-0.2
Schizophrenia (2014)	0.1	0.1	0.4	-0.6	-0.4	-0.1	-0.1
Blood Platelet Count	0.1	1.2	2.5	0.6	-0.9	-1.1	-1.6
Hand grip strength (left)	0.1	0.2	0.7	-0.4	-0.1	-0.4	-0.8
Current tobacco smoking	0.1	0.1	0.3	-0.4	-0.6	0.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	-0.1	-0.3	-0.5
Allergy	0.1	0.3	0.5	0.7	-0.3	-0.3	0.7
Impedance of arm (right)	0.1	0.5	0.8	0.8	0.9	0.1	-0.9
Arm fat percentage (right)	0.1	0.4	1.0	-0.4	-0.5	0.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.3	-0.2	-0.4	0.4
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.3	0.8	-0.5	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.5	0.1	-0.6	-0.3
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.3	0.0	-0.4	-0.7
Medication: Blood pressure	0.1	0.3	0.5	0.7	-0.0	-0.3	0.7
Alcohol intake frequency.	0.1	0.3	1.1	-0.3	-0.0	1.1	-0.1
Arm fat percentage (left)	0.1	0.5	1.8	-0.0	-0.3	0.5	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	0.2	-0.2	0.8	0.2
Age started oral contraceptive pill	0.1	0.1	0.3	-0.1	0.2	0.4	0.5
Cholesterol lowering medication	0.1	0.2	0.8	0.9	-0.0	0.1	0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.0	-0.3	0.2	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.1	0.0	0.0
Hair Pigment	0.0	0.7	1.6	-0.5	-1.3	0.8	-0.5
Tanning	0.0	0.5	1.1	1.1	-0.4	0.3	-0.7
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.1	0.4	0.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	-0.2	-0.2	-0.0	0.4
Leg fat percentage (right)	0.0	0.1	0.4	0.6	-0.1	0.3	-0.3
Average weekly red wine intake	0.0	0.1	0.2	-0.2	-0.0	0.4	-0.2
Smoking status: Current	0.0	0.0	0.1	0.0	-0.3	0.0	-0.1
Medication: Lisinopril	0.0	0.0	0.1	-0.3	-0.0	0.2	-0.1
Leg fat percentage (left)	0.0	0.1	0.3	0.3	-0.2	0.3	-0.5

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Trait associations