Hub : Genes

BMF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0439	0.0236	0.0290	0.004	0.004	0.014	0.005	0.001	0.0730	6.9e-02	2.9e-03	5.5e-02	1.8e-01
2	YFS	Blood	0.0562	0.0185	0.0004	0.007	0.016	0.016	0.018	0.019	0.0015	4.1e-06	5.1e-06	8.4e-07	6.4e-07
3	TCGA	Brain Lower Grade Glioma	0.0329	0.0192	0.0100	-0.002	0.018	0.006	NA	-0.001	0.8600	3.4e-03	6.6e-02	NA	3.9e-01
4	TCGA	Thyroid Carcinoma	0.1050	0.0500	0.0065	0.005	0.020	0.016	NA	0.006	0.1000	4.3e-03	9.1e-03	NA	7.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.7	1.3	0.5	0.7	-0.8	1.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.0	-0.3	0.2	-0.4
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	0.2	0.3	0.7	-0.9
Depression (Nagel 2018)	0.2	0.3	0.6	-0.4	-0.1	0.5	-0.8
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.0	-2.0	1.3	-0.7	1.6
Neuroticism (Nagel 2018)	0.6	1.3	3.3	1.2	1.8	-0.8	-0.1
Schizophrenia (2018)	0.4	0.9	1.3	-0.8	-0.9	0.9	-1.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	-1.5	-0.2	-0.2	-1.1
Worry (Nagel 2018)	2.2	4.5	10.8	2.3	3.3	-1.0	1.0
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	0.0	0.8	0.9	-0.6
Alzheimer’s Disease (in father)	2.1	2.2	6.0	0.1	1.2	-1.3	2.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.1	0.7	0.1	-0.2
Crohns Disease (2017)	0.2	0.4	1.0	0.1	1.0	-0.6	0.7
Irritable Bowel Disease (IBD)	0.1	0.1	0.5	0.3	-0.1	0.7	-0.0
Ulcerative Colitis (UC)	0.5	0.9	2.9	0.1	-0.8	1.7	-0.2
Major Depression (MDD)	0.3	0.4	0.9	-0.6	0.9	-0.5	-0.2
Reaction Time	0.4	0.8	1.3	-0.4	0.7	-1.1	1.0
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.9	-0.4	2.2	-1.4	2.1
Breast Cancer	1.5	3.7	7.9	-0.6	0.6	2.8	-2.4
Ovarian Cancer	1.7	2.2	6.1	-2.5	-0.3	1.6	0.4
Prostate Cancer	0.1	0.1	0.1	-0.4	-0.3	0.1	-0.2
Age at First Birth	1.0	1.5	4.9	0.9	2.2	-0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.1	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	2.4	-1.6	-0.6	0.2	0.9
Coronary Artery Disease (CAD)	0.3	0.4	1.5	1.2	-0.0	0.2	0.2
Crohns Disease (2012)	0.9	1.5	2.6	0.5	1.4	-1.6	1.0
Mean Putamen Volume	1.6	1.9	4.0	0.0	1.8	-2.0	0.4
Fasting Glucose	0.4	0.4	1.1	1.1	0.1	0.8	-0.0
HbA1C	2.8	3.2	8.0	2.8	-1.0	1.1	-1.6
HDL Cholesterol	0.4	0.6	2.0	-0.1	0.7	0.2	1.4
LDL Cholesterol	0.4	0.6	1.6	0.7	-0.3	-1.3	0.6
Lupus	0.3	0.5	1.0	0.8	1.0	0.3	0.5
Neuroticism (2016)	0.5	0.7	1.4	1.2	-0.5	0.3	-1.1
Primary Biliary Cirrhosis	0.8	1.2	2.2	1.4	-0.7	1.5	-0.3
Rheumatoid Arthritis	0.8	1.2	3.0	0.1	-1.7	-1.3	-0.3
Schizophrenia (2014)	0.1	0.1	0.4	-0.6	-0.4	-0.1	-0.1
Triglycerides	2.2	3.6	6.7	2.6	1.6	-2.2	0.7
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	1.4	0.6	-0.5	0.2
Ulcerative Colitis	0.2	0.2	0.8	0.9	-0.1	0.4	0.2
Blood Eosinophil Count	0.4	2.7	5.5	1.9	2.3	1.2	0.6
Blood Platelet Count	0.1	1.2	2.5	0.6	-0.9	-1.1	-1.6
Blood Red Count	1.5	14.3	30.8	-1.1	-5.5	3.0	-4.0
Blood White Count	0.7	5.1	10.1	3.2	1.4	-2.9	0.3
Heel T-Score	0.6	4.9	9.1	3.0	-0.8	-1.6	-2.7
BMI	0.8	4.7	10.8	-3.3	-1.9	1.2	-1.7
Height	0.8	16.0	31.8	-5.6	-3.9	1.8	-3.7
Waist Hip Ratio (WHR)	0.5	2.4	2.9	1.6	1.6	-1.7	1.1
Systolic Blood Pressure	0.7	3.6	8.0	2.8	0.9	2.3	-0.5
Smoking Status	0.2	0.4	0.6	0.5	-0.7	-0.8	0.6
Allergy or Eczema	0.4	0.9	1.8	0.1	1.4	-0.2	-1.3
Cardiovascular Disease	0.3	1.1	3.8	1.9	-0.4	0.7	0.1
Hypothyroidism (self reported)	1.0	2.3	7.9	0.9	2.8	0.7	0.3
Respiratory disease	0.2	0.5	1.3	0.0	1.2	0.6	0.5
Type 2 Diabetes (T2D) (2018)	2.3	4.3	12.4	3.5	2.2	0.1	0.2
Lung FEV1/FVC ratio	4.2	21.4	40.7	6.4	4.1	-4.3	3.1
Lung FVC	3.5	17.7	41.5	-6.4	-3.1	3.6	-2.6
Neuroticism	0.3	0.7	2.1	-0.6	1.4	-0.4	0.2
Chronotype (morning person)	0.6	1.3	3.5	-0.4	0.3	-1.9	1.2
Hair Pigment	0.0	0.7	1.6	-0.5	-1.3	0.8	-0.5
Tanning	0.0	0.5	1.1	1.1	-0.4	0.3	-0.7
Hand grip strength (left)	0.1	0.2	0.7	-0.4	-0.1	-0.4	-0.8
Number of treatments/medications taken	1.2	2.2	4.5	0.7	0.6	-1.9	2.1
Average weekly spirits intake	0.8	1.0	2.1	-1.0	0.5	-0.7	1.5
Sensitivity / hurt feelings	0.2	0.4	0.8	0.9	0.6	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.7	-0.7	-0.2	-0.5
Hearing difficulty/problems: Yes	0.3	0.4	1.4	0.2	-0.2	1.2	0.5
Relative age of first facial hair	0.7	1.4	3.8	1.9	0.7	0.7	1.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.7	-0.7	-0.1	-1.3	1.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	1.2	-0.3	-0.1	0.7
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	-0.8	-0.6	0.1	0.7
Systolic blood pressure, automated reading	0.7	1.9	5.9	2.4	0.5	1.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.2	0.3	1.0	-0.4
Angina	1.1	1.4	2.5	1.4	1.6	0.3	-0.9
Medication for hormone replacement therapy	0.4	0.4	0.7	-0.8	0.6	-0.1	0.8
Vitamin and mineral supplements	0.9	1.2	2.3	-0.0	-1.5	0.6	-1.4
Supplements: Zinc	0.9	1.0	1.9	-1.4	-0.5	0.5	-1.2
Medication: Co-codamol	0.2	0.2	0.3	0.5	0.6	0.6	-0.1
Medication: Metformin	1.5	2.1	5.5	2.4	1.6	0.6	0.4
Diabetes (father)	1.6	1.9	5.5	2.4	1.2	-0.6	0.6
Diabetes (mother)	0.8	1.1	4.0	0.2	-0.3	-0.4	2.0
Severe depression (siblings)	1.1	1.2	2.8	-1.3	0.3	-0.4	-1.7
Pack years adult smoking proportion	0.7	1.0	1.4	-1.0	-1.2	-1.1	0.6
Impedance of leg (right)	0.5	2.4	7.1	2.7	1.6	0.2	-0.1
Leg fat-free mass (left)	0.9	5.0	10.5	-3.2	-2.6	0.7	-1.6
Trunk fat percentage	0.4	1.6	5.3	0.0	-0.6	0.9	-2.3
Hand grip strength (right)	0.2	0.5	1.4	-0.7	-0.3	0.4	-1.2
Townsend deprivation index at recruitment	1.6	2.3	4.4	-1.7	-0.8	1.2	-2.1
Current tobacco smoking	0.1	0.1	0.3	-0.4	-0.6	0.2	-0.3
Average weekly fortified wine intake	1.7	2.0	4.0	0.7	-2.0	1.0	-1.6
Maternal smoking around birth	0.7	1.1	3.0	1.7	1.1	-0.1	0.2
Fed-up feelings	0.3	0.6	1.9	0.2	-0.0	0.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.0	-1.0	-0.8	0.8	-0.4
Relative age voice broke	1.0	1.5	2.5	1.4	1.6	1.2	0.6
Taking other prescription medications	0.2	0.3	1.1	0.0	0.1	-1.0	0.1
Age when periods started (menarche)	0.2	0.6	1.5	-1.2	-0.7	-0.0	0.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.8	1.9	0.8	0.9	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.2	1.5	-0.3	-1.5	-0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.5	-0.1	-0.7	0.3
Qualifications: CSEs or equivalent	1.8	2.4	6.3	-0.6	-1.5	0.8	-2.5
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.1	0.4	0.1	0.1
High blood pressure	0.5	1.3	2.8	1.7	-1.2	-0.0	1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.2	-0.4	1.1	0.5	-1.5
Multivitamins +/- minerals	0.4	0.5	1.0	-0.1	1.0	-0.6	0.9
Stomach or abdominal pain in last month	0.6	0.7	1.5	-0.9	-0.3	-1.2	0.8
Supplements: Glucosamine	0.8	1.0	3.2	0.8	-0.4	1.8	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	-0.2	-0.2	-0.0	0.4
Medication: Atenolol	1.8	2.2	6.2	2.5	1.6	-0.2	0.3
Medication: Levothyroxine sodium	0.6	1.0	1.8	1.3	1.1	1.1	0.0
Sitting height	1.1	7.7	11.6	-3.1	-2.9	1.1	-3.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-0.7	-0.6	1.0	-0.5
High blood pressure (mother)	0.5	0.7	2.1	0.8	-0.3	-0.0	1.4
Body mass index (BMI)	0.2	0.8	1.7	-0.8	-1.3	0.4	-0.8
Impedance of leg (left)	0.5	2.5	6.9	2.6	1.7	-0.2	-0.2
Leg predicted mass (left)	1.0	5.0	10.9	-3.3	-2.5	0.7	-1.6
Trunk fat mass	0.4	1.8	4.2	-1.1	-1.1	0.7	-2.0
Waist circumference	0.3	1.0	2.3	-1.5	-1.2	0.2	-0.6
Number of incorrect matches in round	1.3	2.1	3.9	1.6	-0.1	-1.3	2.0
Past tobacco smoking	0.5	0.9	1.9	-0.9	-0.8	1.4	0.3
Alcohol usually taken with meals	1.4	2.3	4.9	-1.0	1.4	-1.2	2.2
Nervous feelings	2.0	3.7	6.6	1.2	2.6	-2.0	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	-0.1	-0.3	-0.5
Hearing difficulty/problems with background noise	1.2	1.8	4.1	0.6	1.7	-0.4	2.0
Hair/balding pattern: Pattern 2	1.3	1.6	4.4	-2.1	-1.4	0.1	-0.5
Had menopause	0.7	0.8	1.7	1.1	0.0	-0.7	1.3
Had other major operations	0.6	0.7	2.1	0.5	-1.4	0.1	-0.7
Forced vital capacity (FVC)	3.1	11.8	22.2	-4.7	-3.3	2.8	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	1.1	-0.7	-0.4	-1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.4	-0.9	-0.2	-0.3
Qualifications: None of the above	0.8	1.8	3.7	0.6	-0.8	1.5	-1.9
Financial difficulties in last 2 years	1.7	2.2	4.5	-2.1	-1.8	0.9	-0.7
Mouth/teeth dental problems	0.3	0.4	1.3	-0.3	-0.3	-0.5	-1.1
Heart attack	0.5	0.6	1.5	0.8	0.6	-1.2	0.3
Allergy	0.1	0.3	0.5	0.7	-0.3	-0.3	0.7
Pain all over the body in last month	2.4	2.6	5.2	-1.6	-2.3	1.5	-0.7
Diabetes (self-reported)	1.8	2.8	9.4	3.1	1.3	-0.0	0.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.3	-1.8	0.4	1.4	-1.2
Medication: Ramipril	0.8	1.0	1.2	1.1	-1.1	0.9	0.9
Medication: Simvastatin	0.8	1.2	3.8	1.9	-0.2	0.8	-0.5
Fluid intelligence score	0.5	1.1	3.2	-0.5	1.8	-0.4	0.9
Illnesses of siblings	0.5	0.7	2.5	0.0	0.3	0.6	-1.6
Neuroticism score	0.2	0.5	1.1	0.1	1.0	-0.7	-0.5
Weight	0.9	4.6	6.9	-2.6	-2.6	1.1	-1.9
Impedance of arm (right)	0.1	0.5	0.8	0.8	0.9	0.1	-0.9
Arm fat percentage (right)	0.1	0.4	1.0	-0.4	-0.5	0.1	-1.0
Trunk fat-free mass	0.8	4.5	12.7	-3.6	-2.2	0.3	-0.6
Hip circumference	1.2	5.3	11.8	-3.4	-2.4	1.3	-1.3
Time employed in main current job	1.1	1.3	2.2	0.8	0.7	-1.3	1.5
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-0.7	-1.1	0.8	-0.2
Father’s age at death	1.2	1.6	2.5	-0.3	1.6	1.6	-1.1
Worrier / anxious feelings	0.2	0.3	0.7	-0.2	0.8	-0.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.0	-1.4	-2.0	-0.2	-1.0
Falls in the last year	0.8	1.1	2.0	-1.4	-0.4	1.4	-0.6
Hair/balding pattern: Pattern 3	3.0	4.5	7.5	1.6	2.7	-1.9	2.1
Number of live births	1.0	1.3	1.7	0.8	1.3	-1.2	1.3
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	5.2	-2.3	-2.1	1.3	-1.6
Pulse rate	2.7	4.6	10.3	0.4	3.2	-0.3	2.8
Happiness	1.1	1.4	2.9	-1.2	1.7	-1.1	-0.2
Noisy workplace	1.5	1.9	2.6	-1.1	-1.6	1.6	-1.1
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.3	-0.2	-0.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.2	1.1	-0.9	1.5	0.3
Mouth/teeth dental problems: Dentures	2.0	3.4	7.1	0.8	2.4	-0.3	2.7
Asthma	0.5	1.0	1.4	-1.2	1.1	0.8	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.6	-0.6	-1.6	-0.5	-0.2
Medication: Cholesterol lowering	1.3	1.9	5.5	2.4	1.0	-0.5	1.0
Depression (self-reported)	0.4	0.5	1.4	-1.2	-0.3	-0.7	-0.1
Medication: Lansoprazole	0.4	0.5	1.1	-0.4	-0.2	1.1	-0.8
Prospective memory result	0.3	0.4	0.7	0.7	-0.8	0.1	-0.5
Lung cancer (father)	0.4	0.5	1.3	-0.1	-1.1	-0.1	-0.8
Illnesses of mother	2.1	2.6	8.6	-1.1	-0.8	0.0	-2.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.9	-2.2	-1.9	0.5	-1.0
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	-1.0	-0.3	-0.5	0.6
Impedance of arm (left)	0.4	1.9	2.9	1.5	1.4	0.7	-1.7
Arm fat mass (right)	0.3	1.2	1.9	-1.1	-1.2	0.5	-1.4
Trunk predicted mass	0.8	4.5	12.6	-3.5	-2.2	0.3	-0.7
Standing height	0.7	6.6	14.5	-3.8	-2.4	1.1	-2.3
Length of working week for main job	2.7	3.0	9.3	-1.0	-3.0	1.4	-0.1
Exposure to tobacco smoke at home	2.1	2.4	3.9	0.8	-1.5	2.0	-1.7
Breastfed as a baby	0.9	1.1	1.7	-1.3	-1.2	0.7	0.8
Tense / ‘highly strung’	0.8	1.3	3.3	1.8	1.2	-0.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.7	-0.4	-0.9	-0.6
Hair/balding pattern: Pattern 4	1.6	4.0	10.8	1.3	0.5	1.8	-3.3
Birth weight of first child	1.4	2.5	6.7	-1.4	1.0	-0.3	2.6
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.3	0.8	-0.5	-0.4
Pulse wave reflection index	1.2	1.4	2.4	-1.4	-1.2	-0.1	-1.6
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.0	-1.4	-1.1	-0.3	-0.0
Loud music exposure frequency	0.3	0.3	1.0	-0.4	0.2	-0.5	1.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	4.2	-1.0	-2.0	-0.1	1.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.2	1.4	-0.9	-0.5	-2.0
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.1	-1.0	-0.5	0.4
Medication: Paracetamol	2.0	3.3	6.7	-2.5	-2.6	-0.3	-0.3
Headache pain in last month	2.2	3.8	9.0	-1.1	1.1	-3.0	1.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.8	-1.9	0.2	0.0	-0.2
Glaucoma (self-reported)	1.2	1.4	4.9	2.2	0.6	0.6	0.2
Gout (self-reported)	0.3	0.4	1.3	-0.1	-0.5	-0.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.7	0.9	1.9	0.6	0.2
Medication: Amlodipine	2.4	3.4	9.3	0.8	1.7	-0.6	3.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.7	-2.2	-0.5	-0.9	0.2
Birth weight	1.5	3.2	10.4	-3.2	-0.3	-0.7	1.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.8	0.5	0.4	-0.6
High blood pressure (siblings)	0.5	0.8	1.2	-1.1	-0.4	-0.9	0.9
Forced vital capacity (FVC), Best measure	2.5	9.3	22.7	-4.8	-3.2	1.4	-1.5
Body fat percentage	0.2	0.8	2.5	0.2	-0.4	0.6	-1.6
Leg fat percentage (right)	0.0	0.1	0.4	0.6	-0.1	0.3	-0.3
Arm fat-free mass (right)	0.7	3.8	6.9	-2.2	-2.6	1.0	-1.5
Exposure to tobacco smoke outside home	0.4	0.5	0.6	0.7	0.6	-0.8	0.7
Comparative body size at age 10	1.5	4.2	7.8	-2.8	-1.5	-0.5	2.6
Number of full brothers	1.2	1.5	2.9	-0.5	-1.4	1.7	-0.8
Worry too long after embarrassment	0.4	0.6	1.3	-1.0	0.2	-1.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.5	0.1	-0.6	-0.3
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.5	0.8	-0.5	0.4
Number of children fathered	0.5	0.6	1.1	-1.1	-0.6	-0.5	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.0	1.6	0.1	-0.5	2.0
Age at first live birth	0.9	1.6	3.5	0.0	1.9	-1.5	0.7
Pulse wave peak to peak time	0.2	0.2	0.3	0.6	0.1	0.5	-0.3
Health satisfaction	0.3	0.4	0.5	0.6	0.7	-0.7	-0.6
Shortness of breath walking on level ground	0.3	0.3	0.9	-0.1	-1.0	0.3	-0.6
Qualifications: College or University degree	0.2	0.5	0.9	-0.9	1.0	-0.2	0.4
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.3	0.0	-0.4	-0.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.5	0.4	0.3	-1.6	1.6
Emphysema/chronic bronchitis	0.5	0.6	1.1	-1.0	-0.5	-0.2	1.0
Medication for pain relief, constipation, heartburn	1.1	1.8	4.1	-0.2	1.2	2.0	-1.3
Neck or shoulder pain in last month	1.1	1.5	4.8	1.0	-0.2	-2.2	0.5
Medication: Blood pressure	0.1	0.3	0.5	0.7	-0.0	-0.3	0.7
Angina (self-reported)	1.1	1.4	2.8	1.4	1.7	-0.1	-0.9
Migraine (self-reported)	0.3	0.4	1.0	-1.0	-0.6	0.3	-0.0
Medication: Ibuprofen	0.3	0.3	1.3	-0.3	-1.1	-0.2	0.0
Medication: Allopurinol	0.3	0.3	0.9	0.3	0.1	-1.0	0.6
Medication: Omeprazole	0.5	0.6	1.3	-0.8	0.7	-1.1	0.3
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.7	0.9	-0.2	1.3
Mean time to correctly identify matches	0.6	1.2	2.1	0.3	1.2	-1.1	1.4
Heart disease (mother)	0.5	0.7	1.5	-0.2	-1.2	0.2	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.8	2.2	0.1	-0.2	-0.6
Whole body fat mass	0.3	1.5	2.5	-1.0	-1.3	0.8	-1.6
Leg fat mass (right)	0.2	0.9	1.6	-0.9	-1.3	0.7	-0.9
Arm predicted mass (right)	0.7	3.6	6.5	-2.4	-2.6	0.7	-1.3
Pulse rate, automated reading	3.2	10.4	20.9	0.3	4.3	-1.4	4.6
Alcohol intake frequency.	0.1	0.3	1.1	-0.3	-0.0	1.1	-0.1
Comparative height size at age 10	0.8	4.6	11.5	-1.6	-1.7	1.3	-3.4
Number of full sisters	1.6	1.9	4.4	-0.3	-2.1	0.2	-1.8
Suffer from ‘nerves’	1.8	2.8	4.9	0.2	2.2	-1.8	1.8
Overall health rating	0.4	0.8	1.6	1.3	0.9	-0.8	0.6
Chest pain or discomfort	0.6	0.9	1.8	0.4	1.3	-0.6	1.2
Had major operations	0.6	0.7	1.6	-0.6	-0.7	-1.3	0.6
Age at last live birth	1.0	1.4	3.2	0.3	1.5	-1.8	0.6
Family relationship satisfaction	0.2	0.2	0.8	-0.9	0.3	-0.2	-0.2
Leg pain on walking	0.5	0.6	0.9	0.7	-1.0	0.9	-0.5
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	4.4	-2.1	-2.0	0.1	-1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.0	0.7	-0.9	-1.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	1.0	0.7	-0.4	-1.2
Medication: Aspirin	1.3	1.7	4.9	2.2	0.2	-1.3	0.6
Supplements: Vitamin C	0.7	0.8	2.4	0.3	0.3	1.5	-0.7
Knee pain experienced in last month	1.1	1.7	3.5	0.6	-1.5	1.9	-0.9
Hypertension (Self-reported)	0.5	1.3	3.3	1.8	-0.7	-0.1	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	-0.1	1.1	0.7	-0.2
Illnesses of father: Heart disease	0.6	0.8	2.6	0.7	1.6	-0.4	-0.3
Illnesses of siblings: Diabetes	1.3	1.6	3.9	1.3	0.1	-0.9	2.0
Smoking status: Previous	0.5	0.7	1.1	1.1	1.0	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.2	-1.5	-1.8	0.4	-1.4
Whole body fat-free mass	0.9	4.9	12.1	-3.5	-2.4	0.5	-1.2
Leg fat-free mass (right)	1.0	5.1	11.1	-3.3	-2.5	0.4	-1.7
Arm fat percentage (left)	0.1	0.5	1.8	-0.0	-0.3	0.5	-1.3
Average weekly red wine intake	0.0	0.1	0.2	-0.2	-0.0	0.4	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	0.0	0.2	-0.8	0.7
Mood swings	0.4	0.8	2.7	0.4	0.2	0.3	-1.6
Loneliness, isolation	0.6	0.8	1.5	-1.0	0.2	0.7	-1.2
Long-standing illness, disability or infirmity	1.1	1.6	3.3	1.8	1.7	0.4	0.0
Ever had bowel cancer screening	3.4	4.0	5.9	0.1	2.3	-2.2	2.4
Diabetes diagnosed by doctor	1.5	2.5	8.2	2.9	1.0	-0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	5.3	5.6	6.4	2.0	2.5	-2.5	2.4
Friendships satisfaction	0.5	0.6	0.9	-1.0	-0.5	0.6	-0.9
Qualifications: nursing, teaching	0.6	0.9	2.1	-0.2	0.1	-1.1	1.5
Commuting to job workplace: Walk	0.2	0.2	0.6	0.4	-0.2	0.8	0.3
Eye problems/disorders: Cataract	0.7	0.8	1.5	-1.2	-1.1	0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	0.2	-0.2	0.8	0.2
Medication for cholesterol	0.5	0.8	1.6	1.1	0.4	0.6	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.7	1.6	0.2	-0.7	0.6
Back pain experienced in last month	1.4	2.1	5.9	0.2	-2.4	-1.6	-0.1
Mineral and other dietary supplements	0.2	0.3	0.8	-0.5	-0.2	-0.4	-0.9
Breast cancer (self-reported)	0.9	1.1	1.8	1.1	0.4	1.4	-1.1
Asthma (self-reported)	0.4	0.9	1.2	-1.1	1.0	0.8	0.7
Osteoporosis (self-reported)	1.8	2.2	4.5	-0.0	1.4	-1.5	2.1
Osteoarthritis (self-reported)	2.3	2.9	8.5	-1.4	-2.9	1.1	-0.2
Medication: Aspirin	1.2	1.6	5.7	2.4	-0.2	-0.8	0.3
Medication: Gliclazide	0.5	0.6	1.0	1.0	0.6	0.9	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	-0.4	-0.5	0.4	0.9
Smoking status: Current	0.0	0.0	0.1	0.0	-0.3	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.9	-2.2	-0.3	1.7	-0.8
Whole body water mass	0.9	5.0	12.3	-3.5	-2.5	0.5	-1.2
Leg predicted mass (right)	0.9	5.1	11.4	-3.4	-2.5	0.4	-1.6
Arm fat mass (left)	0.3	1.2	2.5	-1.0	-1.1	0.5	-1.6
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	0.5	-0.0	-1.0	1.5
Average weekly champagne plus white wine intake	0.4	0.6	0.7	0.8	-0.7	0.7	-0.8
Miserableness	0.3	0.6	1.7	0.2	-0.7	0.3	-1.3
Guilty feelings	0.2	0.3	1.2	0.1	0.1	0.3	-1.1
Wears glasses or contact lenses	0.3	0.4	1.3	0.5	0.2	0.1	-1.1
Ever taken oral contraceptive pill	0.9	1.0	1.7	0.6	-0.5	-1.3	1.3
Hearing aid user	0.6	0.6	2.3	0.3	0.4	1.5	0.1
Mother’s age at death	0.6	0.8	1.3	0.6	1.2	-0.8	0.8
Financial situation satisfaction	0.3	0.4	1.1	-1.1	-0.5	0.4	-0.3
Tinnitus: Yes, now most or all of the time	2.6	3.1	7.3	-2.7	-1.8	0.7	1.1
Commuting to job workplace: Public transport	0.6	0.8	1.2	-0.8	-1.1	0.9	0.7
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	1.4	0.2	0.2	0.4
Medication: Blood pressure	0.5	0.9	3.4	-0.0	0.3	-0.4	1.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.1	1.0	0.4	-0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.5	0.9	0.7	-0.6	1.6
High cholesterol (Self-reported)	0.7	1.2	1.8	1.3	1.2	-0.1	1.2
Medication: Bendroflumethiazide	0.5	0.8	1.2	0.4	0.9	1.0	1.1
Medication: Paracetamol	1.8	2.8	10.1	-0.8	-3.2	0.5	-0.6
Medication: Lisinopril	0.0	0.0	0.1	-0.3	-0.0	0.2	-0.1
Medication: Atorvastatin	2.9	3.6	8.0	0.7	2.8	-1.4	2.0
Illnesses of father: High blood pressure	3.1	3.8	8.9	-0.9	-1.9	1.4	-3.0
Alcohol drinker status: Never	0.9	1.1	1.8	1.3	0.6	1.1	-1.0
Ever smoked	0.3	0.6	2.0	0.6	0.2	-1.4	-0.3
Basal metabolic rate	1.0	5.3	11.1	-3.3	-2.7	0.7	-1.6
Leg fat percentage (left)	0.0	0.1	0.3	0.3	-0.2	0.3	-0.5
Arm fat-free mass (left)	0.6	3.1	6.3	-2.5	-2.1	0.5	-1.3
Number of operations (self-reported)	0.5	0.7	1.1	0.3	-1.0	-1.1	0.7
Average weekly beer plus cider intake	0.5	0.7	1.7	0.7	-0.7	-0.1	-1.3
Irritability	0.4	0.6	1.2	1.1	0.8	-0.9	-0.1
Risk taking	0.2	0.3	0.6	-0.8	0.5	-0.3	0.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.5	-0.1	1.9	-0.2	0.9
Fractured/broken bones in last 5 years	1.4	1.8	6.8	0.3	-2.6	0.7	0.0
Age started oral contraceptive pill	0.1	0.1	0.3	-0.1	0.2	0.4	0.5
Diastolic blood pressure, automated reading	0.4	1.4	4.6	0.6	-0.3	2.1	-0.6
Ever depressed for a whole week	1.4	1.8	3.0	-1.1	-1.7	-0.6	-1.6
Unable to work because of sickness or disability	1.2	1.6	3.7	-1.9	-1.1	0.2	1.2
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.4	-0.3	0.6	0.6
Myopia	0.3	0.5	1.6	-0.3	-0.5	0.0	-1.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.1	-1.8	0.9	0.0	-0.6
Cholesterol lowering medication	0.1	0.2	0.8	0.9	-0.0	0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.3	0.9	-1.0	-0.3
Pain experienced in last month	0.4	0.7	1.7	-0.5	0.7	1.3	-0.3
Supplements: Calcium	2.3	2.5	9.0	-3.0	-0.9	-0.4	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.6	-0.2	0.6	-0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	0.8	0.8	-1.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	0.2	-1.1	-0.4	0.2
Heart disease (siblings)	0.5	0.7	1.2	0.7	-1.1	-0.6	0.7
Alcohol drinker status: Previous	0.3	0.3	1.0	-0.4	-0.1	-0.2	1.0
Pack years of smoking	0.9	1.3	1.8	-1.1	-1.1	-1.3	0.9
Impedance of whole body	0.6	3.1	7.0	2.6	1.8	0.4	-1.4
Leg fat mass (left)	0.2	0.9	1.4	-1.0	-1.2	0.7	-0.9
Arm predicted mass (left)	0.7	3.6	6.2	-2.5	-2.5	0.4	-1.3