TWAS hub - GCHFR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.2520	0.0950	1.4e-03	0.039	NA	0.053	NA	0.016	3.0e-02	NA	1.4e-02	NA	1.1e-01
2	YFS	Blood	0.0611	0.0164	1.4e-14	0.049	0.05	0.054	0.051	0.051	1.3e-15	5.9e-16	4.0e-17	3.1e-16	2.5e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Father’s age at death	12.4	16.7	31.0	1.5	-5.6
Allergy or Eczema	9.2	24.2	40.7	-6.4	2.8
Systolic Blood Pressure	7.7	38.6	63.8	-8.0	3.7
Systolic blood pressure, automated reading	7.7	22.5	39.7	-6.3	2.3
Cardiovascular Disease	7.6	25.0	42.7	-6.5	2.7
Diastolic blood pressure, automated reading	7.5	23.1	39.9	-6.3	2.5
Risk taking	7.3	10.6	19.0	1.5	4.4
Vascular/heart problems diagnosed by doctor	7.1	19.3	30.1	5.5	-2.9
Illnesses of siblings	6.9	9.7	11.2	2.9	-3.4
Medication: Ventolin 100micrograms inhaler	6.9	8.8	9.9	-3.1	2.8
Medication for cholesterol, blood pressure or diabetes	6.8	11.3	16.1	4.0	-2.6
Hypertension (Self-reported)	6.8	18.8	31.2	-5.6	2.5
Long-standing illness, disability or infirmity	6.8	10.5	13.8	-2.7	3.7
High blood pressure (siblings)	6.7	9.7	11.4	-2.8	3.4
Allergy	6.5	14.9	19.7	4.4	-3.2
Taking other prescription medications	6.4	9.9	11.3	-2.9	3.4
Had menopause	6.4	8.0	16.0	-4.0	0.1
High blood pressure	6.2	17.4	28.7	-5.4	2.5
Hayfever, allergic rhinitis or eczema	6.2	13.4	21.2	-4.6	2.4
Alcohol drinker status: Never	6.2	7.4	14.5	-3.8	0.6
Mouth/teeth dental problems: Loose teeth	5.9	7.1	9.1	3.0	2.2
Prostate Cancer	5.7	8.0	15.3	-0.9	3.9
Medication: Atorvastatin	5.7	7.0	8.6	-2.9	2.3
Past tobacco smoking	5.6	10.3	12.9	-2.8	-3.6
Ever smoked	5.6	9.8	12.7	2.6	3.6
Medication: Cholesterol lowering	4.8	7.5	11.3	-3.4	1.9
Reason for reducing amount of alcohol drunk: Health precaution	4.8	5.7	11.3	0.2	-3.4
Hayfever/allergic rhinitis (self-reported)	4.7	6.2	9.6	-3.1	1.7
Time employed in main current job	4.7	5.4	7.2	1.9	-2.7
Chest pain or discomfort	4.7	6.8	11.3	-1.5	3.4
Smoking Status	4.6	11.0	15.8	2.5	4.0
Supplements: Glucosamine	4.6	6.0	8.5	1.9	-2.9
Overall health rating	4.6	10.0	18.9	-1.0	4.3
Ever had stillbirth, spontaneous miscarriage or termination	4.6	5.0	7.7	-1.5	2.8
Medication: Blood pressure	4.6	8.8	14.2	-3.8	1.8
Townsend deprivation index at recruitment	4.5	6.3	11.0	-1.2	3.3
Commuting to job workplace: Walk	4.3	4.6	7.5	2.7	-1.3
Exposure to tobacco smoke outside home	4.2	5.7	10.8	0.7	3.3
Respiratory disease	4.1	9.1	9.8	-3.1	2.9
Number of treatments/medications taken	4.1	7.3	9.5	-3.1	2.3
Illness, injury, bereavement, stress in last 2 years	4.1	5.0	8.9	-1.0	-3.0
Lung FVC	4.0	20.2	40.2	-6.3	0.4
Medication: Ramipril	4.0	5.2	7.6	-2.7	1.7
Number of live births	3.9	5.5	9.5	-1.2	3.1
Qualifications: NVQ or HND or HNC or equivalent	3.9	4.7	7.3	2.7	1.4
Smoking status: Previous	3.8	5.8	7.2	2.1	2.7
Pack years of smoking	3.8	5.7	10.6	-0.9	3.2
Triglycerides	3.7	6.1	8.2	-2.0	2.9
Illnesses of mother	3.7	4.6	6.8	1.6	-2.6
Birth weight of first child	3.6	6.4	12.7	3.6	-0.5
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	6.7	-2.6	1.4
Breast Cancer	3.5	8.4	15.9	1.0	-4.0
Exposure to tobacco smoke at home	3.5	3.9	4.0	-1.9	2.0
Number of full sisters	3.5	4.2	8.1	0.6	2.8
Pack years adult smoking proportion	3.4	5.2	10.0	-0.7	3.2
Ever unenthusiastic/disinterested for a whole week	3.4	4.2	7.7	2.8	0.8
Neck or shoulder pain in last month	3.3	4.8	9.2	-0.6	3.0
Bipolar Disorder (2018)	3.1	4.8	6.9	1.7	-2.6
Stomach or abdominal pain in last month	3.0	3.8	7.5	-0.0	2.7
Medication: Blood pressure	3.0	5.3	6.3	-2.5	2.1
Medication: Omeprazole	3.0	3.6	6.0	-2.5	1.1
Had major operations	3.0	3.6	6.7	-0.6	2.6
Asthma (self-reported)	3.0	6.0	7.2	-2.2	2.7
Illnesses of father: High blood pressure	3.0	3.7	6.1	-2.5	1.2
Average weekly spirits intake	2.9	3.6	7.2	2.7	-0.0
Illnesses of father: None of the above (group 1)	2.9	3.6	6.9	2.6	0.4
Average weekly beer plus cider intake	2.9	4.2	4.6	2.1	1.9
Hypothyroidism (self reported)	2.8	6.4	8.9	-2.0	3.0
Commuting to job workplace: Cycle	2.8	3.4	6.8	2.6	-0.2
Asthma	2.7	5.4	6.3	-2.1	2.5
Loud music exposure frequency	2.7	2.9	5.3	0.7	2.3
Wheeze or whistling in the chest in last year	2.7	4.8	9.1	-0.7	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.2	5.6	-2.4	0.8
Unable to work because of sickness or disability	2.7	3.4	6.3	0.8	2.5
Ulcerative Colitis (UC)	2.6	4.9	9.0	3.0	-0.8
Lupus	2.5	3.8	4.3	-1.8	2.1
Ulcerative Colitis	2.5	3.6	7.1	2.7	-0.1
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	4.7	1.3	2.2
Alcohol intake frequency.	2.5	5.7	7.8	-2.8	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.4	10.5	-3.2	-0.4
Pain experienced in last month	2.5	4.2	8.1	0.5	-2.9
Waist Hip Ratio (WHR)	2.4	10.9	13.4	2.9	3.7
Age when periods started (menarche)	2.4	5.7	11.4	3.4	-0.0
Number of operations (self-reported)	2.4	3.6	6.4	-0.9	2.5
Ever used hormone-replacement therapy (HRT)	2.3	2.9	4.2	-2.1	1.2
Serious illness, injury or assault to yourself	2.3	2.7	3.0	1.6	1.7
Multivitamins +/- minerals	2.3	2.9	5.8	2.4	-0.0
Illnesses of father: Heart disease	2.3	3.2	6.3	-2.5	0.2
Smoking status: Current	2.3	3.6	5.8	1.2	2.4
Average weekly champagne plus white wine intake	2.3	3.1	5.0	1.1	-2.2
High cholesterol (Self-reported)	2.3	4.1	6.8	-2.6	1.2
Bipolar Disorder or Schizophrenia	2.2	5.4	8.1	1.7	-2.8
Medication for cholesterol	2.2	3.4	5.3	2.3	-1.2
Heart disease (siblings)	2.2	2.7	3.7	-1.9	1.3
Medication: Amlodipine	2.1	2.9	5.1	-2.3	0.8
Birth weight	2.1	4.6	6.1	2.5	-1.8
Angina (self-reported)	2.1	2.8	5.4	-0.5	2.3
Number of self-reported non-cancer illnesses	2.1	3.7	4.2	-2.1	1.8
Medication: Lisinopril	2.1	2.7	4.6	-2.1	0.9
Reaction Time	2.0	3.9	3.9	2.0	-2.0
Neuroticism (2016)	2.0	2.8	3.0	-1.6	1.7
Angina	2.0	2.6	5.1	-0.4	2.2
High blood pressure (mother)	2.0	2.8	4.6	-0.9	2.2
Had other major operations	2.0	2.4	4.2	-2.0	0.8
Qualifications: A levels/AS levels or equivalent	2.0	4.5	6.7	-1.5	-2.6
Length of working week for main job	2.0	2.2	3.4	1.0	-1.8
Eye problems/disorders: Glaucoma	2.0	2.4	4.2	-2.0	0.7
Major Depression (MDD)	1.9	2.3	2.9	1.3	1.7
Hearing difficulty/problems: Yes	1.9	2.8	5.4	-0.5	2.3
Maternal smoking around birth	1.9	2.8	3.9	2.0	1.3
Medication: Levothyroxine sodium	1.9	3.1	3.7	-1.6	1.9
Financial difficulties in last 2 years	1.9	2.6	3.4	-1.3	1.9
Pain all over the body in last month	1.9	2.1	2.3	-1.4	1.5
Pulse wave reflection index	1.9	2.4	2.6	-1.6	1.5
Osteoporosis (self-reported)	1.9	2.3	4.7	-2.2	-0.2
Mother’s age at death	1.9	2.3	3.8	-0.9	-1.9
HDL Cholesterol	1.8	3.0	3.7	1.5	-1.9
Current tobacco smoking	1.8	3.0	5.0	1.0	2.2
Leg fat percentage (right)	1.8	6.5	12.5	-3.5	0.7
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	4.8	2.2	-0.9
Alcohol drinker status: Previous	1.8	2.0	2.2	1.4	1.5
Schizophrenia vs Biploar Disorder	1.7	2.2	2.7	1.3	-1.6
Mean Putamen Volume	1.7	2.0	2.9	-1.7	-1.0
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	4.7	-1.3	2.2
Number of children fathered	1.7	1.9	2.7	1.6	1.0
Health satisfaction	1.7	2.2	3.5	-0.9	1.9
Qualifications: College or University degree	1.7	5.4	10.8	0.3	-3.3
Migraine (self-reported)	1.7	2.1	2.7	1.2	-1.7
Age started oral contraceptive pill	1.7	2.1	3.2	-1.8	-0.9
Mouth/teeth dental problems	1.6	2.4	3.3	-1.8	-1.2
Mouth/teeth dental problems: Dentures	1.6	2.7	5.1	0.6	2.3
Ever highly irritable/argumentative for 2 days	1.5	1.9	3.5	-0.5	1.9
Medication for pain relief, constipation, heartburn	1.5	2.5	3.6	1.2	-1.9
Diabetes diagnosed by doctor	1.5	2.5	4.9	-0.2	2.2
Alzheimer’s Disease (in father)	1.4	1.5	3.0	-0.4	-1.7
Fed-up feelings	1.4	2.6	3.4	-1.9	1.4
Qualifications: None of the above	1.4	3.0	5.8	-0.4	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.4	-0.4	2.1
Pulse wave peak to peak time	1.4	1.7	3.3	1.8	0.2
Mean time to correctly identify matches	1.4	2.8	3.8	1.3	-1.9
Average weekly red wine intake	1.4	2.0	2.7	1.6	-1.1
Loneliness, isolation	1.4	2.0	3.9	-0.1	2.0
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.8	-1.7	0.9
Leg fat percentage (left)	1.4	5.2	9.8	-3.1	0.7
Height	1.3	24.6	48.9	7.0	-0.6
Arm fat percentage (right)	1.3	5.1	8.9	-3.0	1.1
Glaucoma (self-reported)	1.3	1.5	2.6	-1.6	0.6
Arm fat percentage (left)	1.3	5.2	9.8	-3.1	0.8
Verbal and Numeric Reasoning (VNR)	1.2	2.9	3.8	-2.0	-1.4
Blood Red Count	1.2	11.4	22.8	4.8	-0.1
Diabetes (mother)	1.2	1.5	3.1	0.1	1.8
Qualifications: CSEs or equivalent	1.2	1.6	2.1	1.1	1.4
Hearing difficulty/problems with background noise	1.2	1.9	2.4	-1.5	1.2
Medication: Simvastatin	1.2	1.8	3.4	-1.8	0.5
Medication: Lansoprazole	1.2	1.4	2.2	-0.7	1.5
Lung cancer (father)	1.2	1.4	1.8	1.3	1.0
Comparative body size at age 10	1.2	3.2	6.0	-2.5	-0.6
Shortness of breath walking on level ground	1.2	1.4	1.9	-1.4	1.0
Illnesses of siblings: Diabetes	1.2	1.4	2.8	-0.2	1.7
Medication: Bendroflumethiazide	1.2	1.9	3.6	-1.9	-0.3
Irritability	1.2	2.0	3.0	1.0	1.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	1.9	-1.4	1.1
Alcohol usually taken with meals	1.1	1.8	2.0	-1.3	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.1	-0.6	1.8
Standing height	1.1	10.7	20.2	4.5	-1.1
Body fat percentage	1.1	4.2	8.1	-2.8	0.5
Number of full brothers	1.1	1.4	2.5	-0.6	1.6
Age at first live birth	1.1	2.0	4.0	0.0	-2.0
Leg pain on walking	1.1	1.4	2.7	-0.1	1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.5	-1.6	-0.3
Depressed Affect (Nagel 2018)	1.0	2.1	2.5	-1.6	1.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.3	-0.9	1.1
Medication: Metformin	1.0	1.4	2.9	-0.0	1.7
Diabetes (self-reported)	1.0	1.6	3.1	0.2	1.8
Pulse wave Arterial Stiffness index	1.0	1.2	2.4	-1.5	-0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.5	0.1	1.6
Blood clot in the leg (DVT)	1.0	1.2	1.7	-1.3	0.9
Gout (self-reported)	1.0	1.4	2.7	1.6	0.1
Mood swings	1.0	1.7	3.2	-0.5	1.8
Breast cancer (self-reported)	1.0	1.2	2.1	-1.4	0.6
Basal cell carcinoma (self-reported)	1.0	1.1	2.2	1.5	-0.2
Intelligence (Savage-Jansen 2018)	0.9	2.6	3.4	-1.4	-1.8
Chronotype (morning person)	0.9	2.0	3.6	-0.7	-1.9
Hair/balding pattern: Pattern 2	0.9	1.2	2.4	1.5	-0.0
Alcohol intake versus 10 years previously	0.9	1.4	2.8	-0.3	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.3	1.0	1.1
Medication: Paracetamol	0.9	1.6	3.1	-0.2	1.8
Headache pain in last month	0.9	1.5	3.0	-0.0	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.0	-0.5	1.4
Age at last live birth	0.9	1.3	2.3	1.5	-0.5
Mineral and other dietary supplements	0.9	1.2	1.5	-1.0	1.2
Hearing aid user	0.9	1.0	1.4	-1.2	0.8
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.8	1.4	0.6
Fractured/broken bones in last 5 years	0.9	1.2	1.8	1.3	0.8
Fasting Glucose	0.8	1.0	1.4	0.8	-1.2
Blood White Count	0.8	5.7	11.3	3.4	-0.3
Heart attack	0.8	1.1	1.6	-0.7	1.3
Noisy workplace	0.8	1.0	2.0	0.3	1.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.5	-1.6	-0.3
Leg fat mass (right)	0.8	3.2	6.0	-2.4	0.7
Family relationship satisfaction	0.8	0.9	1.8	0.3	1.4
Knee pain experienced in last month	0.8	1.2	2.2	0.4	1.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.7	-1.3	-0.2
Leg fat mass (left)	0.8	3.0	5.3	-2.3	0.9
Schizophrenia (2018)	0.7	1.5	2.4	0.8	-1.5
Ovarian Cancer	0.7	0.9	1.1	-1.0	-0.9
Schizophrenia (2014)	0.7	1.6	2.4	0.9	-1.6
Type 2 Diabetes (T2D) (2018)	0.7	1.2	1.3	1.1	1.1
Severe depression (siblings)	0.7	0.8	1.2	1.1	0.7
Trunk fat percentage	0.7	2.9	5.7	-2.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.1	-1.0	0.6
Sitting height	0.7	5.1	9.2	3.0	-0.9
Body mass index (BMI)	0.7	3.1	5.0	-2.2	1.1
Trunk fat-free mass	0.7	4.2	8.5	2.9	-0.1
Happiness	0.7	0.9	1.6	1.3	-0.3
Trunk predicted mass	0.7	4.1	8.2	2.9	-0.1
Worry too long after embarrassment	0.7	1.2	1.7	-1.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	1.6	0.2	1.3
Supplements: Vitamin C	0.7	0.8	1.7	-1.3	-0.1
Miserableness	0.7	1.2	2.2	-0.4	1.5
Guilty feelings	0.7	1.1	2.1	-0.1	1.5
Medication: Paracetamol	0.7	1.1	2.2	-0.0	1.5
Supplements: Calcium	0.7	0.8	1.1	0.6	-1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.3	-0.7	1.2
Neuroticism (Nagel 2018)	0.6	1.3	1.4	-1.2	1.1
Crohns Disease (2017)	0.6	1.3	2.6	-1.6	-0.2
Body Mass Index (BMI) (2010)	0.6	0.9	1.2	-0.8	1.1
HbA1C	0.6	0.7	1.4	-0.3	1.2
Rheumatoid Arthritis	0.6	0.9	1.8	1.3	0.0
Blood Eosinophil Count	0.6	4.2	7.7	-0.9	2.8
Hand grip strength (left)	0.6	1.7	2.0	1.4	-1.2
Sensitivity / hurt feelings	0.6	1.1	2.0	-1.4	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.8	-0.0	1.3
Hand grip strength (right)	0.6	1.7	2.7	1.6	-0.8
Average weekly fortified wine intake	0.6	0.7	1.3	-0.0	-1.2
Fluid intelligence score	0.6	1.2	1.6	-0.9	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.1	-1.8	-0.6
Arm fat mass (right)	0.6	2.5	3.9	-2.0	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	0.5	1.3
Forced vital capacity (FVC), Best measure	0.6	2.2	4.4	-2.1	-0.3
Medication: Seretide 50 evohaler	0.6	0.7	1.1	-0.6	1.1
Arm predicted mass (right)	0.6	3.2	6.4	2.5	-0.2
Medication: Aspirin	0.6	0.8	1.0	-1.0	0.8
Whole body fat-free mass	0.6	3.4	6.9	2.6	-0.1
Back pain experienced in last month	0.6	0.9	1.9	0.1	1.4
Medication: Aspirin	0.6	0.8	1.3	-1.1	0.5
Whole body water mass	0.6	3.2	6.3	2.5	-0.0
Arm fat mass (left)	0.6	2.3	4.1	-2.0	0.7
Ever taken oral contraceptive pill	0.6	0.6	0.7	0.8	-0.8
Irritable Bowel Disease (IBD)	0.5	1.1	1.7	1.3	-0.8
Age at First Birth	0.5	0.7	1.4	-1.2	0.2
LDL Cholesterol	0.5	0.8	1.0	1.0	0.7
BMI	0.5	2.7	5.1	-2.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	1.8	-1.4	0.5
Medication: Atenolol	0.5	0.6	0.7	-0.7	0.8
Waist circumference	0.5	1.9	3.7	-0.2	1.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	2.9	-1.7	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	-1.1	0.3
Eye problems/disorders: None of the above	0.5	0.6	1.0	0.4	-1.0
Medication: Ibuprofen	0.5	0.6	0.8	0.6	0.9
Medication: Allopurinol	0.5	0.7	0.9	1.0	0.7
Heart disease (mother)	0.5	0.6	0.9	-0.6	1.0
Myopia	0.5	0.7	1.2	-0.5	-1.1
Bipolar Disorder (2011)	0.4	0.3	0.7	0.1	-0.8
Coronary Artery Disease (CAD)	0.4	0.5	0.9	-1.0	-0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.4	0.7	0.7
Heel T-Score	0.4	3.6	6.9	-2.6	0.5
Neuroticism	0.4	1.1	1.9	-0.5	1.4
Worrier / anxious feelings	0.4	0.8	1.4	-1.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	0.9	0.5
Arm fat-free mass (right)	0.4	1.9	3.8	2.0	-0.2
Whole body fat mass	0.4	1.6	2.9	-1.7	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.2	0.9
Leg fat-free mass (right)	0.4	2.1	4.2	2.0	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	-0.2	-1.0
Leg predicted mass (right)	0.4	2.1	4.1	2.0	-0.2
Financial situation satisfaction	0.4	0.5	0.8	-0.3	0.9
Commuting to job workplace: Public transport	0.4	0.4	0.6	-0.8	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.6	-0.8
Arm fat-free mass (left)	0.4	2.2	4.0	2.0	0.6
Ever depressed for a whole week	0.4	0.5	1.1	1.0	-0.1
Cholesterol lowering medication	0.4	0.6	1.0	-1.0	0.4
Arm predicted mass (left)	0.4	1.8	3.3	1.8	0.5
Depression (Nagel 2018)	0.3	0.4	0.6	-0.8	0.5
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	0.7	0.4
Primary Biliary Cirrhosis	0.3	0.5	0.6	-0.8	-0.5
Blood Platelet Count	0.3	3.9	4.7	-2.2	1.8
Hair Pigment	0.3	9.7	18.6	4.3	-1.0
Medication for hormone replacement therapy	0.3	0.4	0.7	-0.8	-0.0
Vitamin and mineral supplements	0.3	0.5	0.5	-0.7	-0.6
Supplements: Zinc	0.3	0.4	0.7	0.8	0.0
Medication: Co-codamol	0.3	0.3	0.4	-0.6	0.5
Forced vital capacity (FVC)	0.3	1.3	2.6	-1.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.2	-1.1	-0.3
Neuroticism score	0.3	0.5	0.7	-0.6	0.8
Tense / ‘highly strung’	0.3	0.4	0.6	-0.5	0.8
Pulse rate, automated reading	0.3	1.1	1.5	1.2	-0.8
Comparative height size at age 10	0.3	1.8	3.4	1.9	-0.5
Qualifications: nursing, teaching	0.3	0.4	0.6	0.5	-0.8
Basal metabolic rate	0.3	1.9	3.7	1.9	0.1
Leg fat-free mass (left)	0.2	0.9	1.8	1.4	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	-0.5	0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	0.4	0.5
Leg predicted mass (left)	0.2	0.9	1.8	1.3	-0.0
Trunk fat mass	0.2	1.1	2.0	-1.4	0.3
Nervous feelings	0.2	0.3	0.6	0.8	0.1
Hip circumference	0.2	0.6	1.3	-1.1	-0.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.7	-0.4
Suffer from ‘nerves’	0.2	0.3	0.6	-0.1	0.7
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	0.2
Medication: Gliclazide	0.2	0.2	0.3	-0.3	0.6
Wears glasses or contact lenses	0.2	0.3	0.6	-0.7	-0.0
Crohns Disease (2012)	0.1	0.2	0.2	-0.3	-0.5
Lung FEV1/FVC ratio	0.1	0.4	0.6	0.8	-0.4
Ever had hysterectomy (womb removed)	0.1	0.2	0.2	0.3	-0.4
Impedance of leg (right)	0.1	0.3	0.5	-0.7	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	0.5	-0.2
Number of incorrect matches in round	0.1	0.1	0.1	0.2	0.4
Impedance of arm (right)	0.1	0.3	0.5	-0.4	0.7
Falls in the last year	0.1	0.1	0.1	0.2	0.3
Depression (self-reported)	0.1	0.1	0.1	0.4	-0.2
Prospective memory result	0.1	0.1	0.2	0.1	0.5
Impedance of arm (left)	0.1	0.3	0.7	-0.8	-0.2
Breastfed as a baby	0.1	0.1	0.2	0.4	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.6	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.4	0.6
Eye problems/disorders: Cataract	0.1	0.2	0.2	0.4	-0.3
Worry (Nagel 2018)	0.0	0.0	0.0	0.1	0.2
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.3	-0.1
Tanning	0.0	0.1	0.2	0.4	0.2
Relative age of first facial hair	0.0	0.1	0.1	-0.4	-0.1
Diabetes (father)	0.0	0.0	0.0	0.1	0.1
Relative age voice broke	0.0	0.0	0.0	0.2	0.0
Impedance of leg (left)	0.0	0.0	0.1	0.0	0.3
Weight	0.0	0.2	0.4	-0.1	0.6
Pulse rate	0.0	0.0	0.0	0.2	-0.1
Peak expiratory flow (PEF)	0.0	0.0	0.0	-0.1	-0.2
Friendships satisfaction	0.0	0.0	0.0	-0.2	0.2
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.0	0.3
Impedance of whole body	0.0	0.1	0.1	-0.3	-0.3

Hub : Genes

GCHFR

Models

Trait associations