Best TWAS P=1.79e-09 · Best GWAS P=2.87e-10 conditioned to 1.01e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | TEAD3 | 0.36 | 0.29 | enet | 27 | 0.32 | 8.4e-25 | 4.5 | -5.3 | 1.2e-07 | -0.09 | 0.69 | 0.30 | FALSE |
| 2 | GTEx | Colon Transverse | RPL10A | 0.12 | 0.05 | lasso | 4 | 0.05 | 2.5e-03 | -4.5 | -5.3 | 1.2e-07 | -0.06 | 0.12 | 0.56 | FALSE |
| 3 | GTEx | Lung | RPL10A | 0.21 | 0.09 | enet | 53 | 0.09 | 1.2e-07 | -4.7 | -5.3 | 1.5e-07 | -0.03 | 0.55 | 0.42 | FALSE |
| 4 | GTEx | Thyroid | C6orf106 | 0.09 | 0.01 | enet | 29 | 0.01 | 1.1e-01 | -5.7 | -5.9 | 4.4e-09 | -0.10 | 0.06 | 0.37 | TRUE |
| 5 | GTEx | Uterus | UHRF1BP1 | 0.20 | 0.03 | lasso | 4 | 0.07 | 1.8e-02 | -4.5 | -5.1 | 3.0e-07 | 0.13 | 0.08 | 0.32 | FALSE |
| 6 | METSIM | Adipose | PPARD | 0.04 | 0.00 | enet | 19 | 0.01 | 3.9e-03 | 2.8 | -5.7 | 1.5e-08 | 0.14 | 0.10 | 0.10 | TRUE |
| 7 | NTR | Blood | C6orf106 | 0.03 | 0.02 | lasso | 6 | 0.02 | 7.2e-07 | -5.7 | -5.4 | 5.1e-08 | 0.05 | 0.09 | 0.91 | FALSE |
| 8 | NTR | Blood | SRPK1 | 0.03 | 0.02 | blup | 452 | 0.02 | 3.8e-06 | 3.6 | 5.1 | 2.7e-07 | -0.17 | 0.97 | 0.01 | FALSE |
| 9 | NTR | Blood | ZNF76 | 0.01 | 0.00 | blup | 424 | 0.00 | 3.8e-02 | -3.9 | 5.6 | 1.7e-08 | -0.17 | 0.20 | 0.18 | FALSE |
| 10 | YFS | Blood | RPL10A | 0.24 | 0.11 | lasso | 11 | 0.13 | 4.4e-39 | -4.7 | -5.1 | 3.0e-07 | -0.01 | 0.58 | 0.41 | FALSE |
| 11 | YFS | Blood | SNRPC | 0.02 | 0.03 | lasso | 5 | 0.02 | 3.0e-08 | -5.4 | 5.2 | 1.8e-07 | -0.12 | 0.07 | 0.93 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPL10A | 0.03 | 0.00 | blup | 54 | 0.02 | 6.0e-03 | -4.6 | -6.0 | 2.0e-09 | 0.03 | 0.04 | 0.14 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCP11 | 0.03 | 0.03 | blup | 49 | 0.04 | 6.6e-08 | -5.5 | -5.3 | 1.0e-07 | 0.07 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf106 | 0.04 | 0.05 | lasso | 4 | 0.03 | 8.1e-05 | -5.7 | -5.7 | 1.4e-08 | 0.09 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | C6orf126 | 0.03 | 0.00 | enet | 8 | 0.01 | 1.8e-02 | 4.4 | 5.3 | 1.3e-07 | 0.04 | 0.00 | 0.39 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | FKBP5 | 0.04 | 0.05 | lasso | 2 | 0.04 | 5.4e-05 | -5.9 | -6.0 | 1.8e-09 | -0.08 | 0.00 | 1.00 | TRUE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TCP11 | 0.03 | 0.03 | lasso | 3 | 0.04 | 3.8e-05 | -5.5 | -5.5 | 5.0e-08 | 0.13 | 0.00 | 0.99 | FALSE |