[Hub]/) : Traits : Lung FVC :

chr6:33,856,903-36,581,149

Best TWAS P=1.79e-09 · Best GWAS P=2.87e-10 conditioned to 1.01e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells Transformed fibroblasts TEAD3 0.36 0.29 enet 27 0.32 8.4e-25 4.5 -5.3 1.2e-07 -0.09 0.69 0.30 FALSE
2 GTEx Colon Transverse RPL10A 0.12 0.05 lasso 4 0.05 2.5e-03 -4.5 -5.3 1.2e-07 -0.06 0.12 0.56 FALSE
3 GTEx Lung RPL10A 0.21 0.09 enet 53 0.09 1.2e-07 -4.7 -5.3 1.5e-07 -0.03 0.55 0.42 FALSE
4 GTEx Thyroid C6orf106 0.09 0.01 enet 29 0.01 1.1e-01 -5.7 -5.9 4.4e-09 -0.10 0.06 0.37 TRUE
5 GTEx Uterus UHRF1BP1 0.20 0.03 lasso 4 0.07 1.8e-02 -4.5 -5.1 3.0e-07 0.13 0.08 0.32 FALSE
6 METSIM Adipose PPARD 0.04 0.00 enet 19 0.01 3.9e-03 2.8 -5.7 1.5e-08 0.14 0.10 0.10 TRUE
7 NTR Blood C6orf106 0.03 0.02 lasso 6 0.02 7.2e-07 -5.7 -5.4 5.1e-08 0.05 0.09 0.91 FALSE
8 NTR Blood SRPK1 0.03 0.02 blup 452 0.02 3.8e-06 3.6 5.1 2.7e-07 -0.17 0.97 0.01 FALSE
9 NTR Blood ZNF76 0.01 0.00 blup 424 0.00 3.8e-02 -3.9 5.6 1.7e-08 -0.17 0.20 0.18 FALSE
10 YFS Blood RPL10A 0.24 0.11 lasso 11 0.13 4.4e-39 -4.7 -5.1 3.0e-07 -0.01 0.58 0.41 FALSE
11 YFS Blood SNRPC 0.02 0.03 lasso 5 0.02 3.0e-08 -5.4 5.2 1.8e-07 -0.12 0.07 0.93 FALSE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma RPL10A 0.03 0.00 blup 54 0.02 6.0e-03 -4.6 -6.0 2.0e-09 0.03 0.04 0.14 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma TCP11 0.03 0.03 blup 49 0.04 6.6e-08 -5.5 -5.3 1.0e-07 0.07 0.00 1.00 FALSE
14 The Cancer Genome Atlas Brain Lower Grade Glioma C6orf106 0.04 0.05 lasso 4 0.03 8.1e-05 -5.7 -5.7 1.4e-08 0.09 0.01 0.99 FALSE
15 The Cancer Genome Atlas Lung Adenocarcinoma C6orf126 0.03 0.00 enet 8 0.01 1.8e-02 4.4 5.3 1.3e-07 0.04 0.00 0.39 FALSE
16 The Cancer Genome Atlas Lung Adenocarcinoma FKBP5 0.04 0.05 lasso 2 0.04 5.4e-05 -5.9 -6.0 1.8e-09 -0.08 0.00 1.00 TRUE
17 The Cancer Genome Atlas Prostate Adenocarcinoma TCP11 0.03 0.03 lasso 3 0.04 3.8e-05 -5.5 -5.5 5.0e-08 0.13 0.00 0.99 FALSE