[Hub]/) : Traits : HDL Cholesterol : ← →

chr17:36,710,513-39,048,774

Best TWAS P=1.46e-15 · Best GWAS P=8.7e-14 conditioned to 0.129

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ORMDL3	0.09	0.08	enet	10	0.06	4.2e-08	-6.0	-5.6	2.6e-08	0.42	0.98	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PNMT	0.05	0.00	bslmm	327	0.00	8.2e-02	-7.4	5.8	7.4e-09	-0.66	0.03	0.51	FALSE
3	GTEx	Adipose Visceral Omentum	PGAP3	0.12	0.11	lasso	6	0.10	7.1e-06	-7.0	-7.1	1.6e-12	0.90	0.06	0.93	FALSE
4	GTEx	Adrenal Gland	PGAP3	0.17	0.14	lasso	2	0.12	3.2e-05	-7.0	-7.2	8.1e-13	0.91	0.24	0.62	FALSE
5	GTEx	Artery Aorta	PGAP3	0.13	0.04	lasso	3	0.10	5.3e-06	-7.0	-6.5	6.5e-11	0.75	0.20	0.75	FALSE
6	GTEx	Artery Coronary	PGAP3	0.16	0.10	lasso	4	0.06	5.9e-03	-6.2	-6.5	5.9e-11	0.86	0.13	0.47	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	5.5	5.8	7.5e-09	-0.38	0.09	0.39	FALSE
8	GTEx	Breast Mammary Tissue	PGAP3	0.10	0.07	lasso	4	0.07	1.5e-04	-6.8	-5.7	1.2e-08	0.81	0.09	0.71	FALSE
9	GTEx	Breast Mammary Tissue (Female)	PGAP3	0.10	-0.01	enet	18	0.01	2.0e-01	-7.0	-5.3	1.1e-07	0.66	0.04	0.47	FALSE
10	GTEx	Cells Transformed fibroblasts	GSDMB	0.11	0.02	enet	18	0.06	4.9e-05	-6.0	-6.2	6.6e-10	0.38	0.84	0.08	FALSE
11	GTEx	Cells Transformed fibroblasts	STARD3	0.08	0.01	enet	18	0.01	3.3e-02	-7.0	-5.9	3.6e-09	0.61	0.18	0.47	FALSE
12	GTEx	Cells Transformed fibroblasts	ORMDL3	0.24	0.09	enet	21	0.07	7.8e-06	-6.0	-6.0	1.9e-09	0.38	0.97	0.02	FALSE
13	GTEx	Colon Transverse	GSDMB	0.14	0.11	enet	18	0.12	2.0e-06	5.5	-6.4	1.2e-10	0.54	0.59	0.40	FALSE
14	GTEx	Colon Transverse	PGAP3	0.24	0.20	enet	19	0.20	8.3e-10	-7.0	-7.0	1.8e-12	0.86	0.16	0.84	FALSE
15	GTEx	Esophagus Mucosa	GSDMB	0.06	0.04	lasso	3	0.03	4.7e-03	-5.1	-5.6	2.7e-08	0.39	0.20	0.26	FALSE
16	GTEx	Esophagus Muscularis	FBXL20	0.04	0.03	lasso	3	0.02	1.2e-02	-5.1	6.0	2.1e-09	-0.64	0.25	0.32	FALSE
17	GTEx	Esophagus Muscularis	PGAP3	0.11	0.08	enet	10	0.10	1.1e-06	-7.0	-7.2	4.5e-13	0.89	0.14	0.85	FALSE
18	GTEx	Heart Atrial Appendage	PPP1R1B	0.09	0.04	enet	10	0.08	2.2e-04	-4.9	-7.0	3.6e-12	0.65	0.24	0.58	FALSE
19	GTEx	Heart Atrial Appendage	ERBB2	0.13	0.04	enet	18	0.02	4.8e-02	-6.8	-7.0	2.8e-12	0.66	0.15	0.48	FALSE
20	GTEx	Heart Atrial Appendage	PNMT	0.14	-0.01	lasso	8	0.00	5.3e-01	5.5	-7.1	9.0e-13	0.69	0.09	0.56	FALSE
21	GTEx	Heart Atrial Appendage	PGAP3	0.13	0.16	lasso	3	0.18	2.6e-08	-6.5	-6.8	1.4e-11	0.88	0.39	0.60	FALSE
22	GTEx	Heart Left Ventricle	PNMT	0.06	0.03	lasso	1	0.03	1.3e-02	-7.0	-7.0	3.2e-12	0.74	0.16	0.56	FALSE
23	GTEx	Heart Left Ventricle	PGAP3	0.17	0.14	lasso	5	0.12	4.3e-07	-7.0	-7.2	7.4e-13	0.89	0.12	0.88	FALSE
24	GTEx	Liver	PGAP3	0.27	0.17	lasso	4	0.13	1.7e-04	-7.0	-6.5	1.1e-10	0.83	0.14	0.81	FALSE
25	GTEx	Lung	GSDMB	0.07	0.07	lasso	4	0.05	1.5e-04	-6.0	-6.7	2.4e-11	0.56	0.12	0.79	FALSE
26	GTEx	Lung	PGAP3	0.24	0.14	lasso	7	0.12	2.3e-09	-7.1	-7.2	4.5e-13	0.89	0.16	0.84	FALSE
27	GTEx	Lung	ORMDL3	0.16	0.13	enet	15	0.14	1.6e-10	-6.0	-6.0	1.5e-09	0.48	0.99	0.01	FALSE
28	GTEx	Muscle Skeletal	PGAP3	0.04	0.03	lasso	5	0.04	1.3e-04	-7.0	-7.7	1.6e-14	0.84	0.07	0.90	FALSE
29	GTEx	Nerve Tibial	ERBB2	0.08	0.08	lasso	5	0.07	1.3e-05	-6.5	-7.0	3.5e-12	0.89	0.26	0.74	FALSE
30	GTEx	Nerve Tibial	PGAP3	0.19	0.11	lasso	5	0.12	1.1e-08	-7.0	-7.2	5.0e-13	0.87	0.20	0.80	FALSE
31	GTEx	Pancreas	PGAP3	0.37	0.25	lasso	6	0.21	1.9e-09	-7.0	-7.1	1.7e-12	0.86	0.19	0.81	FALSE
32	GTEx	Pituitary	PGAP3	0.15	0.22	lasso	2	0.19	1.8e-05	-6.8	-6.8	1.3e-11	0.86	0.22	0.38	FALSE
33	GTEx	Prostate	PGAP3	0.23	0.03	enet	26	0.06	1.6e-02	-7.1	-8.0	1.5e-15	0.83	0.12	0.53	TRUE
34	GTEx	Skin Not Sun Exposed Suprapubic	PGAP3	0.22	0.09	enet	33	0.14	3.4e-08	-7.0	-6.9	6.3e-12	0.78	0.16	0.84	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	TCAP	0.07	0.02	enet	7	0.01	1.2e-01	-6.6	-6.8	1.1e-11	0.87	0.09	0.46	FALSE
36	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	-6.6	-7.5	4.4e-14	0.82	0.16	0.59	FALSE
37	GTEx	Skin Sun Exposed Lower leg	PGAP3	0.14	0.10	lasso	6	0.07	1.1e-06	-7.0	-7.2	5.8e-13	0.93	0.20	0.80	FALSE
38	GTEx	Skin Sun Exposed Lower leg	ORMDL3	0.04	0.02	lasso	5	0.01	1.1e-01	-7.0	-6.6	3.5e-11	0.84	0.10	0.41	FALSE
39	GTEx	Small Intestine Terminal Ileum	FBXL20	0.32	0.32	lasso	5	0.27	1.1e-06	-5.9	6.0	2.2e-09	-0.66	0.25	0.64	FALSE
40	GTEx	Small Intestine Terminal Ileum	RP11-690G19.3	0.21	0.24	lasso	2	0.24	5.3e-06	-5.9	6.1	9.6e-10	-0.65	0.19	0.57	FALSE
41	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	-6.0	-6.4	1.5e-10	0.44	0.98	0.01	FALSE
42	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	-6.0	-6.3	3.5e-10	0.45	0.97	0.02	FALSE
43	GTEx	Stomach	PGAP3	0.41	0.18	enet	16	0.25	2.3e-12	-7.1	-6.3	3.5e-10	0.77	0.19	0.81	FALSE
44	GTEx	Thyroid	PGAP3	0.19	0.21	lasso	10	0.24	3.5e-18	-6.1	-7.0	2.1e-12	0.84	0.47	0.53	FALSE
45	GTEx	Thyroid	RP11-690G19.3	0.04	0.03	enet	6	0.02	1.5e-02	-6.9	7.6	2.6e-14	-0.87	0.09	0.72	FALSE
46	GTEx	Whole Blood	GSDMB	0.15	0.10	lasso	4	0.10	4.5e-09	-6.0	-6.1	9.5e-10	0.51	0.99	0.01	FALSE
47	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	-6.0	-5.8	5.3e-09	0.43	0.99	0.01	FALSE
48	METSIM	Adipose	PGAP3	0.06	0.05	lasso	4	0.05	8.8e-08	-7.0	-7.3	3.1e-13	0.92	0.12	0.88	FALSE
49	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	-6.0	-6.0	1.6e-09	0.49	0.97	0.03	FALSE
50	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	5.4	5.7	9.4e-09	-0.43	0.99	0.01	FALSE
51	NTR	Blood	ORMDL3	0.10	0.10	enet	24	0.12	4.4e-36	5.6	-5.8	6.9e-09	0.48	0.99	0.01	FALSE
52	YFS	Blood	FBXL20	0.05	0.10	lasso	15	0.10	6.5e-30	-6.7	-6.7	1.5e-11	0.74	0.32	0.68	FALSE
53	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	-6.2	-6.0	2.2e-09	0.47	0.97	0.03	FALSE
54	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	-6.2	-5.8	5.8e-09	0.46	0.97	0.03	FALSE
55	YFS	Blood	PGAP3	0.08	0.12	lasso	11	0.12	1.7e-35	-7.1	-7.2	6.6e-13	0.90	0.09	0.91	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PGAP3	0.07	0.12	blup	37	0.11	1.2e-09	-7.0	-7.3	2.1e-13	0.90	0.06	0.94	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	PGAP3	0.08	0.07	blup	41	0.08	2.7e-16	-7.0	-5.1	2.9e-07	0.76	0.06	0.94	FALSE
58	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PGAP3	0.04	0.01	blup	41	0.01	1.2e-01	-7.0	-7.4	1.6e-13	0.93	0.02	0.73	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	5.6	-5.7	9.0e-09	0.47	0.03	0.97	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	PGAP3	0.10	0.17	blup	37	0.17	6.4e-10	-7.0	-7.3	2.6e-13	0.93	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Glioblastoma Multiforme	PGAP3	0.19	0.13	blup	37	0.16	1.5e-05	-7.0	-7.2	7.7e-13	0.91	0.04	0.93	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PGAP3	0.04	0.08	lasso	1	0.07	1.5e-08	-7.0	-7.0	2.2e-12	0.89	0.06	0.94	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STARD3	0.03	0.04	enet	5	0.02	8.2e-04	-7.0	-7.2	8.5e-13	0.88	0.03	0.96	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MED1	0.03	0.02	blup	29	0.02	1.0e-03	-6.7	-6.4	1.8e-10	0.72	0.01	0.98	FALSE
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	5.6	-5.8	5.3e-09	0.44	0.02	0.60	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PGAP3	0.12	0.12	lasso	4	0.13	5.3e-14	-7.0	-7.1	1.4e-12	0.90	0.05	0.95	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMB	0.06	0.05	enet	7	0.05	2.2e-06	-6.1	-6.0	2.0e-09	0.49	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	PGAP3	0.05	0.08	lasso	10	0.08	2.1e-09	-7.0	-7.0	3.5e-12	0.89	0.07	0.93	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PGAP3	0.09	0.11	lasso	4	0.11	5.9e-06	-6.8	-7.0	2.1e-12	0.91	0.03	0.96	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMB	0.05	0.07	blup	39	0.05	1.4e-06	-5.0	-6.3	3.5e-10	0.49	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	PGAP3	0.06	0.06	lasso	4	0.06	4.5e-07	-6.4	-6.7	2.3e-11	0.84	0.15	0.85	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	STARD3	0.05	0.02	blup	50	0.02	1.1e-03	-6.4	-6.0	1.7e-09	0.67	0.06	0.62	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMB	0.02	0.01	blup	39	0.01	1.5e-02	-5.0	-5.9	3.5e-09	0.47	0.02	0.82	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ORMDL3	0.03	0.04	lasso	2	0.04	2.9e-05	5.7	-5.5	4.2e-08	0.48	0.03	0.97	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PGAP3	0.06	0.10	lasso	2	0.09	1.5e-10	-7.0	-7.0	1.8e-12	0.89	0.07	0.93	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STARD3	0.03	0.03	enet	8	0.04	6.6e-05	-6.6	-6.9	4.0e-12	0.89	0.09	0.86	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMB	0.14	0.16	lasso	4	0.14	2.4e-06	5.5	-5.5	3.7e-08	0.45	0.08	0.91	FALSE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PGAP3	0.07	0.10	lasso	2	0.08	3.7e-04	-7.5	-7.5	6.9e-14	0.76	0.01	0.93	FALSE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PGAP3	0.17	0.13	blup	41	0.10	6.8e-05	-6.4	-6.3	2.2e-10	0.82	0.07	0.85	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	PGAP3	0.18	0.26	enet	12	0.28	5.7e-30	-7.0	-7.1	1.6e-12	0.88	0.06	0.94	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	STARD3	0.05	0.04	blup	50	0.05	9.8e-06	-7.0	-6.3	2.2e-10	0.82	0.03	0.96	FALSE
82	The Cancer Genome Atlas	Rectum Adenocarcinoma	CDK12	0.17	0.00	blup	44	0.05	2.5e-02	-6.6	-6.6	3.1e-11	0.72	0.01	0.41	FALSE
83	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	5.0	-5.9	3.5e-09	0.47	0.02	0.89	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	PGAP3	0.20	0.14	blup	38	0.16	1.4e-04	-6.8	-6.3	2.2e-10	0.88	0.02	0.74	FALSE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	-6.1	-6.0	1.7e-09	0.45	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	IKZF3	0.03	0.01	blup	43	0.02	1.3e-02	-6.2	5.5	4.1e-08	-0.44	0.01	0.74	FALSE
87	The Cancer Genome Atlas	Stomach Adenocarcinoma	PGAP3	0.05	0.05	lasso	4	0.05	1.0e-04	-6.7	-7.6	2.4e-14	0.91	0.01	0.97	FALSE
88	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZPBP2	0.08	0.09	enet	5	0.10	6.1e-08	-6.2	6.2	7.0e-10	-0.47	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PGAP3	0.23	0.22	blup	38	0.24	3.6e-09	-7.0	-7.2	7.1e-13	0.87	0.04	0.96	FALSE
90	The Cancer Genome Atlas	Testicular Germ Cell Tumors	STARD3	0.05	0.06	lasso	2	0.04	1.7e-02	-7.0	-7.6	2.5e-14	0.92	0.02	0.70	FALSE
91	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	-6.1	-6.0	1.9e-09	0.49	0.01	0.99	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	ORMDL3	0.08	0.13	blup	37	0.15	3.8e-14	-6.0	-6.1	8.5e-10	0.45	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	PGAP3	0.10	0.16	lasso	5	0.17	1.4e-16	-7.0	-7.2	4.5e-13	0.92	0.06	0.94	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	PNMT	0.03	0.05	lasso	4	0.04	6.2e-05	-7.5	-7.6	2.7e-14	0.80	0.00	0.99	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	STARD3	0.10	0.06	lasso	5	0.05	2.6e-05	-6.6	-6.4	1.7e-10	0.84	0.11	0.87	FALSE