[Hub]/) : Traits : Heel T-Score : ← →

chr12:25,417,418-31,526,510

Best TWAS P=1.14e-22 · Best GWAS P=4.91e-40 conditioned to 5.1e-16

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MRPS35	0.07	0.00	bslmm	555	0.03	8.0e-05	-3.6	-5.1	2.8e-07	0.12	0.05	0.21	FALSE
2	GTEx	Adipose Subcutaneous	RP11-967K21.1	0.08	0.02	lasso	8	0.01	2.1e-02	-3.1	-5.2	2.5e-07	-0.02	0.26	0.54	TRUE
3	GTEx	Adipose Subcutaneous	RP11-996F15.2	0.46	0.38	lasso	10	0.38	4.1e-33	6.1	6.1	1.0e-09	0.04	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-996F15.2	0.40	0.34	enet	12	0.33	7.9e-18	6.1	5.9	4.2e-09	0.04	1.00	0.00	FALSE
5	GTEx	Adrenal Gland	CCDC91	0.16	0.01	lasso	16	0.03	3.5e-02	3.9	-5.3	1.3e-07	0.01	0.16	0.04	FALSE
6	GTEx	Adrenal Gland	RP11-996F15.2	0.62	0.55	lasso	7	0.55	3.0e-23	6.1	6.0	1.6e-09	0.04	1.00	0.00	FALSE
7	GTEx	Artery Aorta	IPO8	0.17	0.06	enet	29	0.04	2.2e-03	-4.6	-5.8	7.1e-09	-0.11	0.02	0.93	TRUE
8	GTEx	Artery Aorta	RP11-996F15.2	0.35	0.28	lasso	4	0.28	1.5e-15	6.1	6.1	9.7e-10	0.04	1.00	0.00	FALSE
9	GTEx	Artery Coronary	RP11-996F15.2	0.54	0.44	enet	20	0.43	9.0e-16	6.0	5.4	7.1e-08	0.03	1.00	0.00	FALSE
10	GTEx	Artery Tibial	RP11-996F15.2	0.44	0.40	enet	28	0.44	1.2e-37	6.0	5.3	1.0e-07	0.04	1.00	0.00	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-996F15.2	0.30	0.11	enet	24	0.17	3.7e-05	6.1	5.2	1.6e-07	0.02	0.58	0.02	FALSE
12	GTEx	Brain Cerebellum	RP11-996F15.2	0.25	0.15	lasso	4	0.10	7.6e-04	6.1	6.2	7.2e-10	0.04	0.15	0.05	FALSE
13	GTEx	Brain Putamen basal ganglia	STK38L	0.28	0.08	lasso	7	0.05	2.6e-02	4.5	5.5	5.1e-08	-0.01	0.01	0.34	FALSE
14	GTEx	Breast Mammary Tissue	RP11-283G6.5	0.17	0.02	enet	9	0.02	2.9e-02	-2.4	6.4	1.4e-10	0.67	0.05	0.60	TRUE
15	GTEx	Breast Mammary Tissue	RP11-996F15.2	0.45	0.35	lasso	8	0.31	1.2e-16	6.0	6.0	1.8e-09	0.04	1.00	0.00	FALSE
16	GTEx	Breast Mammary Tissue (Male)	RP11-996F15.2	0.52	0.28	lasso	9	0.23	4.1e-06	6.1	6.1	8.1e-10	0.05	0.36	0.06	FALSE
17	GTEx	Breast Mammary Tissue (Female)	RP11-996F15.2	0.42	0.38	lasso	1	0.35	3.5e-11	6.1	6.1	1.0e-09	0.04	0.99	0.01	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	RP11-996F15.2	0.27	0.24	lasso	4	0.23	6.0e-08	6.1	6.1	1.1e-09	0.03	0.97	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	ERGIC2	0.12	0.03	enet	23	0.05	1.4e-04	6.1	-5.5	3.2e-08	-0.07	0.94	0.00	FALSE
20	GTEx	Cells Transformed fibroblasts	CCDC91	0.10	0.10	lasso	5	0.09	5.5e-07	-5.6	-5.4	7.9e-08	0.07	0.98	0.00	FALSE
21	GTEx	Cells Transformed fibroblasts	RP11-967K21.1	0.07	0.07	lasso	2	0.07	3.7e-06	-6.1	6.3	3.5e-10	-0.05	0.98	0.00	FALSE
22	GTEx	Cells Transformed fibroblasts	RP11-996F15.2	0.34	0.33	lasso	7	0.34	7.3e-26	6.1	5.8	6.5e-09	0.03	1.00	0.00	FALSE
23	GTEx	Colon Sigmoid	RP11-996F15.2	0.42	0.27	lasso	7	0.29	7.7e-11	6.1	5.7	9.8e-09	0.04	1.00	0.00	FALSE
24	GTEx	Colon Transverse	RP11-996F15.2	0.31	0.32	lasso	1	0.31	3.5e-15	6.1	6.1	1.0e-09	0.04	1.00	0.00	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	RP11-996F15.2	0.50	0.42	lasso	8	0.42	1.4e-16	6.1	6.0	2.2e-09	0.03	1.00	0.00	FALSE
26	GTEx	Esophagus Mucosa	MRPS35	0.18	0.00	enet	20	0.01	6.6e-02	-3.3	6.0	1.7e-09	-0.05	0.10	0.04	FALSE
27	GTEx	Esophagus Mucosa	RP11-996F15.2	0.39	0.43	lasso	7	0.45	6.2e-33	6.1	5.9	3.7e-09	0.04	1.00	0.00	FALSE
28	GTEx	Esophagus Muscularis	RP11-996F15.2	0.56	0.45	enet	31	0.47	1.3e-31	6.1	5.3	1.4e-07	0.04	1.00	0.00	FALSE
29	GTEx	Heart Atrial Appendage	RP11-967K21.1	0.08	0.09	lasso	1	0.08	2.3e-04	-6.1	6.2	7.8e-10	-0.03	0.48	0.04	FALSE
30	GTEx	Lung	RP11-996F15.2	0.50	0.46	lasso	5	0.46	1.9e-39	6.1	6.0	2.1e-09	0.03	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	RP11-967K21.1	0.04	0.01	lasso	9	0.00	2.9e-01	-5.8	6.5	1.1e-10	-0.07	0.30	0.04	FALSE
32	GTEx	Muscle Skeletal	RP11-996F15.2	0.24	0.26	lasso	11	0.25	9.3e-25	6.0	6.0	2.5e-09	0.04	1.00	0.00	FALSE
33	GTEx	Nerve Tibial	RP11-996F15.2	0.52	0.53	lasso	5	0.56	3.3e-47	6.1	5.7	1.2e-08	0.05	1.00	0.00	FALSE
34	GTEx	Ovary	RP11-996F15.2	0.50	0.46	enet	22	0.54	1.1e-15	5.8	6.3	3.6e-10	0.04	1.00	0.00	FALSE
35	GTEx	Pancreas	RP11-996F15.2	0.56	0.46	enet	22	0.48	1.8e-22	6.1	6.0	2.7e-09	0.03	1.00	0.00	FALSE
36	GTEx	Pituitary	RP11-996F15.2	0.54	0.42	lasso	8	0.32	7.7e-09	6.1	5.8	7.3e-09	0.05	0.97	0.00	FALSE
37	GTEx	Prostate	RP11-996F15.2	0.49	0.36	enet	32	0.39	6.0e-11	6.1	5.4	8.3e-08	0.02	0.95	0.00	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	CCDC91	0.26	0.05	lasso	15	0.04	4.1e-03	-6.4	-7.7	1.4e-14	0.06	0.92	0.00	TRUE
39	GTEx	Skin Sun Exposed Lower leg	CCDC91	0.09	0.01	enet	8	0.01	2.6e-02	-6.1	-5.4	6.1e-08	0.03	0.58	0.02	FALSE
40	GTEx	Skin Sun Exposed Lower leg	RP11-996F15.2	0.50	0.48	enet	21	0.50	1.5e-47	6.0	5.6	1.9e-08	0.04	1.00	0.00	FALSE
41	GTEx	Small Intestine Terminal Ileum	RP11-996F15.2	0.60	0.51	lasso	5	0.46	7.1e-12	6.0	5.9	4.4e-09	0.04	0.98	0.00	FALSE
42	GTEx	Spleen	RP11-996F15.2	0.53	0.49	lasso	5	0.46	1.7e-13	6.0	6.2	4.1e-10	0.05	1.00	0.00	FALSE
43	GTEx	Stomach	RP11-996F15.2	0.35	0.41	lasso	3	0.40	1.4e-20	6.1	6.1	1.4e-09	0.04	1.00	0.00	FALSE
44	GTEx	Testis	RP11-996F15.2	0.28	0.35	lasso	2	0.37	2.7e-17	6.1	5.9	4.1e-09	0.03	1.00	0.00	FALSE
45	GTEx	Thyroid	RP11-996F15.2	0.54	0.54	lasso	8	0.55	9.1e-50	6.0	6.0	1.7e-09	0.04	1.00	0.00	FALSE
46	GTEx	Vagina	RP11-996F15.2	0.44	0.31	enet	23	0.27	5.9e-07	6.0	5.5	3.1e-08	0.03	0.83	0.01	FALSE
47	GTEx	Whole Blood	RP11-996F15.2	0.20	0.18	enet	11	0.18	9.2e-17	6.1	6.6	4.4e-11	0.04	1.00	0.00	FALSE
48	METSIM	Adipose	MRPS35	0.06	0.00	blup	542	0.01	2.1e-02	-3.0	6.5	6.6e-11	-0.06	0.13	0.06	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	RASSF8	0.06	0.01	enet	19	0.03	6.6e-05	-1.5	-6.3	3.7e-10	-0.24	0.29	0.27	TRUE
50	ROSMAP	Brain Pre-frontal Cortex	MED21	0.08	0.00	blup	537	0.04	1.6e-05	3.0	5.8	7.7e-09	0.02	0.13	0.43	TRUE
51	ROSMAP	Brain Pre-frontal Cortex	RP11-996F15.2	0.21	0.22	lasso	7	0.24	5.1e-30	6.1	5.7	1.5e-08	0.04	1.00	0.00	FALSE
52	YFS	Blood	ITPR2	0.27	0.19	lasso	7	0.22	1.9e-69	6.6	-6.4	1.9e-10	-0.65	1.00	0.00	TRUE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC91	0.04	0.04	lasso	3	0.03	1.8e-06	-6.1	-6.2	6.2e-10	0.05	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERGIC2	0.03	0.00	blup	62	0.02	2.6e-04	-2.8	-5.4	7.2e-08	-0.05	0.02	0.66	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERGIC2	0.04	0.03	lasso	2	0.03	1.3e-04	6.1	-6.0	1.8e-09	-0.04	0.00	0.99	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC91	0.09	0.11	lasso	2	0.12	2.3e-05	-6.1	-6.1	1.2e-09	0.05	0.70	0.09	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	BHLHE41	0.03	0.02	enet	9	0.02	2.8e-03	-4.3	5.7	1.4e-08	0.21	0.10	0.04	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	ERGIC2	0.19	0.10	blup	62	0.11	1.1e-10	5.8	-6.7	2.9e-11	-0.05	0.00	1.00	TRUE
59	The Cancer Genome Atlas	Thyroid Carcinoma	SSPN	0.08	0.03	lasso	4	0.04	7.5e-05	-9.7	9.8	1.1e-22	0.16	0.24	0.02	TRUE