Hub : Genes

BHLHE41

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.1930 0.0770 0.0051 0.028 NA 0.012 NA 0.010 0.0160 NA 0.0830 NA 0.100
2 TCGA Prostate Adenocarcinoma 0.0263 0.0136 0.0033 0.021 0.018 0.021 NA 0.014 0.0025 0.0045 0.0028 NA 0.011

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.6 -0.1 -0.8
Bipolar Disorder or Schizophrenia 1.3 3.1 5.9 -0.6 -2.4
Depressed Affect (Nagel 2018) 0.6 1.2 1.7 0.8 1.3
Depression (Nagel 2018) 0.0 0.0 0.1 -0.1 0.3
Intelligence (Savage-Jansen 2018) 1.7 5.2 10.0 3.2 0.6
Neuroticism (Nagel 2018) 0.2 0.4 0.6 0.8 0.4
Schizophrenia (2018) 1.6 3.3 6.0 -0.7 -2.5
Schizophrenia vs Biploar Disorder 1.6 2.1 2.5 -1.6 1.3
Worry (Nagel 2018) 0.1 0.3 0.6 0.2 0.8
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.6 0.2
Alzheimer’s Disease (in father) 0.6 0.7 1.4 -1.2 -0.0
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 -0.3 -0.0
Crohns Disease (2017) 0.6 1.3 1.9 -1.4 -0.8
Irritable Bowel Disease (IBD) 0.7 1.7 2.4 -1.6 -1.0
Ulcerative Colitis (UC) 0.6 1.2 1.9 -0.7 -1.4
Major Depression (MDD) 0.5 0.6 1.0 -0.5 1.0
Reaction Time 2.1 3.9 7.6 -2.8 -0.5
Verbal and Numeric Reasoning (VNR) 1.5 3.6 7.2 2.7 -0.1
Breast Cancer 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.7 1.0 1.5 -0.7 1.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.3 1.9 3.4 -1.9 -0.5
Bipolar Disorder (2011) 2.7 2.6 4.5 -0.9 -2.1
Body Mass Index (BMI) (2010) 1.1 1.5 3.1 1.8 0.1
Coronary Artery Disease (CAD) 1.9 2.3 3.6 -1.0 1.9
Crohns Disease (2012) 0.4 0.6 0.6 -0.7 -0.8
Mean Putamen Volume 1.8 2.1 4.1 2.0 0.0
Fasting Glucose 0.4 0.5 0.6 0.8 0.6
HbA1C 0.7 0.8 1.6 -0.2 -1.3
HDL Cholesterol 1.6 2.6 2.8 1.7 -1.6
LDL Cholesterol 0.0 0.0 0.0 0.0 -0.1
Lupus 0.2 0.4 0.6 -0.4 -0.7
Neuroticism (2016) 0.5 0.7 1.4 -1.2 -0.1
Primary Biliary Cirrhosis 0.2 0.3 0.6 -0.8 -0.2
Rheumatoid Arthritis 0.6 0.8 1.1 1.0 -0.8
Schizophrenia (2014) 0.7 1.5 2.5 -0.7 -1.6
Triglycerides 1.5 2.4 4.2 0.8 2.0
Type 2 Diabetes (T2D) (2012) 1.0 1.1 1.2 1.0 1.1
Ulcerative Colitis 1.6 2.3 2.6 -1.5 -1.6
Blood Eosinophil Count 0.4 2.8 5.0 0.8 2.2
Blood Platelet Count 0.0 0.1 0.2 -0.4 -0.1
Blood Red Count 0.5 4.6 5.2 2.3 2.0
Blood White Count 2.2 16.0 26.8 -2.3 5.2
Heel T-Score 3.3 26.2 32.1 -4.5 5.7
BMI 0.1 0.3 0.4 -0.6 0.5
Height 0.1 1.0 1.8 -0.4 -1.3
Waist Hip Ratio (WHR) 5.6 25.0 36.0 -3.8 6.0
Systolic Blood Pressure 3.4 17.0 26.9 -2.6 5.2
Smoking Status 0.1 0.2 0.2 0.4 0.5
Allergy or Eczema 1.0 2.5 4.4 2.1 0.8
Cardiovascular Disease 2.1 7.0 11.6 -1.5 3.4
Hypothyroidism (self reported) 1.1 2.5 3.9 1.1 2.0
Respiratory disease 0.2 0.4 0.5 -0.5 0.7
Type 2 Diabetes (T2D) (2018) 2.9 5.4 7.4 -2.7 1.8
Lung FEV1/FVC ratio 0.0 0.2 0.3 0.6 -0.3
Lung FVC 0.6 3.0 4.7 1.2 -2.2
Neuroticism 0.5 1.3 2.5 1.6 0.2
Chronotype (morning person) 0.5 1.2 1.6 -1.2 0.9
Hair Pigment 0.5 13.8 21.7 2.4 4.7
Tanning 0.5 6.2 9.0 -1.9 -3.0
Hand grip strength (left) 0.3 0.8 1.5 -1.2 0.2
Number of treatments/medications taken 0.9 1.7 2.3 -1.0 1.5
Average weekly spirits intake 2.0 2.5 4.2 0.9 -2.0
Sensitivity / hurt feelings 0.1 0.1 0.2 0.0 -0.5
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 0.0 0.6
Hearing difficulty/problems: Yes 2.1 3.2 6.5 2.5 -0.0
Relative age of first facial hair 0.3 0.5 1.0 0.3 1.0
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 3.5 -1.9 -0.1
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.2 -0.3 -1.5
Ever had hysterectomy (womb removed) 0.2 0.3 0.5 -0.2 -0.7
Systolic blood pressure, automated reading 2.8 8.2 11.5 -2.2 3.4
Eye problems/disorders: Diabetes related eye disease 1.1 1.3 2.5 0.1 1.6
Angina 1.0 1.4 2.6 1.6 -0.4
Medication for hormone replacement therapy 1.1 1.3 1.6 -0.9 -1.3
Vitamin and mineral supplements 0.5 0.7 1.2 -1.1 0.5
Supplements: Zinc 0.2 0.2 0.4 -0.1 0.7
Medication: Co-codamol 0.2 0.2 0.5 0.7 0.1
Medication: Metformin 6.2 8.7 13.0 -2.1 3.6
Diabetes (father) 2.0 2.4 4.9 0.2 2.2
Diabetes (mother) 4.7 5.9 10.6 1.1 3.3
Severe depression (siblings) 0.6 0.6 0.7 -0.8 -0.7
Pack years adult smoking proportion 1.1 1.7 3.4 -0.2 1.8
Impedance of leg (right) 0.1 0.5 0.5 -0.6 -0.7
Leg fat-free mass (left) 0.0 0.1 0.1 0.3 -0.1
Trunk fat percentage 0.1 0.3 0.5 -0.4 -0.7
Hand grip strength (right) 0.3 0.8 1.5 -1.2 -0.3
Townsend deprivation index at recruitment 2.3 3.3 4.4 2.1 1.5
Current tobacco smoking 0.2 0.3 0.6 -0.8 0.3
Average weekly fortified wine intake 0.7 0.9 1.7 -1.3 0.2
Maternal smoking around birth 1.5 2.1 4.2 -2.1 -0.0
Fed-up feelings 0.4 0.7 1.3 0.3 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.0 -0.6 1.0
Relative age voice broke 1.2 1.8 2.9 1.7 -0.8
Taking other prescription medications 0.3 0.5 1.1 -0.1 1.0
Age when periods started (menarche) 2.0 4.8 6.9 -2.6 -1.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 -0.6 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 2.6 5.9 6.9 -2.2 2.6
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.3 1.8 0.5
Qualifications: CSEs or equivalent 2.4 3.1 4.5 -2.1 -1.3
Serious illness, injury or assault to yourself 0.6 0.7 1.1 0.6 -1.0
High blood pressure 2.3 6.5 9.8 -1.8 3.1
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.5 1.2 0.4
Multivitamins +/- minerals 0.2 0.3 0.5 0.2 -0.7
Stomach or abdominal pain in last month 0.0 0.0 0.0 0.1 0.1
Supplements: Glucosamine 1.2 1.5 3.0 1.7 0.2
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 4.1 -0.7 -2.0
Medication: Atenolol 0.6 0.8 1.6 -1.3 -0.1
Medication: Levothyroxine sodium 1.3 2.1 3.5 0.9 1.9
Sitting height 0.0 0.1 0.2 -0.2 -0.4
Chronic bronchitis/emphysema (father) 1.7 2.0 3.6 1.9 0.7
High blood pressure (mother) 0.1 0.2 0.2 -0.5 -0.4
Body mass index (BMI) 0.0 0.1 0.3 -0.0 0.5
Impedance of leg (left) 0.1 0.3 0.5 -0.7 -0.2
Leg predicted mass (left) 0.0 0.1 0.1 0.4 -0.1
Trunk fat mass 0.0 0.2 0.2 -0.4 -0.4
Waist circumference 0.6 2.2 2.5 -1.4 1.6
Number of incorrect matches in round 0.6 1.0 2.0 -1.4 0.1
Past tobacco smoking 0.2 0.4 0.6 -0.8 -0.3
Alcohol usually taken with meals 0.4 0.6 0.6 -0.8 0.8
Nervous feelings 0.0 0.0 0.0 -0.0 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.2 -1.1 0.7
Hearing difficulty/problems with background noise 2.3 3.7 6.7 2.6 0.8
Hair/balding pattern: Pattern 2 2.0 2.6 4.0 -1.1 2.0
Had menopause 0.6 0.8 1.4 -0.3 -1.2
Had other major operations 1.2 1.5 2.0 -1.4 1.0
Forced vital capacity (FVC) 1.1 4.1 8.0 0.4 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 2.9 6.7 7.3 -2.5 2.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.9 -0.6 0.9
Qualifications: None of the above 0.6 1.2 2.2 1.5 -0.4
Financial difficulties in last 2 years 0.9 1.2 2.2 0.4 -1.5
Mouth/teeth dental problems 0.1 0.2 0.2 -0.3 -0.5
Heart attack 1.8 2.3 4.0 2.0 -0.7
Allergy 0.0 0.0 0.0 -0.2 -0.2
Pain all over the body in last month 2.1 2.3 2.7 1.7 1.4
Diabetes (self-reported) 3.4 5.3 7.9 -1.6 2.8
Hayfever/allergic rhinitis (self-reported) 1.6 2.2 3.9 -2.0 -0.6
Medication: Ramipril 2.4 3.1 3.9 -2.0 1.5
Medication: Simvastatin 2.4 3.5 4.2 -1.7 2.0
Fluid intelligence score 1.4 3.0 5.9 2.4 -0.1
Illnesses of siblings 0.3 0.5 0.9 1.0 0.1
Neuroticism score 0.3 0.5 1.1 1.0 -0.1
Weight 0.0 0.1 0.1 -0.4 -0.1
Impedance of arm (right) 0.8 3.8 5.3 -1.5 -2.3
Arm fat percentage (right) 0.0 0.0 0.0 0.0 -0.1
Trunk fat-free mass 0.1 0.4 0.7 -0.0 0.9
Hip circumference 0.4 1.8 3.3 0.6 -1.8
Time employed in main current job 1.8 2.0 2.4 -1.5 1.3
Alcohol intake versus 10 years previously 0.2 0.3 0.5 0.7 0.0
Father’s age at death 0.1 0.1 0.1 0.3 -0.3
Worrier / anxious feelings 0.1 0.3 0.5 -0.7 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.1 0.5 1.4
Falls in the last year 1.3 1.8 3.4 0.4 -1.9
Hair/balding pattern: Pattern 3 5.0 7.5 10.1 2.2 -3.2
Number of live births 0.2 0.2 0.5 0.1 -0.7
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 6.0 0.7 -2.4
Pulse rate 1.7 2.9 5.7 -2.4 0.3
Happiness 1.0 1.2 1.3 1.2 1.1
Noisy workplace 0.1 0.1 0.1 -0.2 0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.5 0.7 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.1 1.1 -0.5
Mouth/teeth dental problems: Dentures 0.2 0.3 0.7 -0.2 0.8
Asthma 0.6 1.3 1.7 -1.3 0.9
Medication: Ibuprofen (e.g. Nurofen) 2.9 3.6 6.0 2.5 -1.1
Medication: Cholesterol lowering 0.7 1.1 1.4 -0.8 1.2
Depression (self-reported) 1.2 1.5 1.9 -1.4 -1.0
Medication: Lansoprazole 0.7 0.8 1.3 1.2 0.5
Prospective memory result 0.1 0.2 0.3 -0.1 -0.6
Lung cancer (father) 2.5 3.0 4.8 -1.1 -2.2
Illnesses of mother 0.5 0.6 1.2 0.2 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 3.9 0.8 -2.0
Pulse wave Arterial Stiffness index 0.6 0.7 0.7 0.8 0.8
Impedance of arm (left) 1.2 5.7 9.5 -1.4 -3.1
Arm fat mass (right) 0.0 0.0 0.1 -0.0 0.3
Trunk predicted mass 0.1 0.4 0.7 -0.1 0.8
Standing height 0.1 1.4 1.7 -1.1 -1.3
Length of working week for main job 0.0 0.0 0.0 0.1 0.1
Exposure to tobacco smoke at home 0.4 0.4 0.8 -0.2 -0.9
Breastfed as a baby 1.0 1.2 1.8 -1.3 -0.8
Tense / ‘highly strung’ 1.2 2.0 3.4 0.8 -1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 0.6 0.7 -0.8
Hair/balding pattern: Pattern 4 2.4 5.8 7.6 2.0 -2.8
Birth weight of first child 0.8 1.4 2.8 1.7 -0.1
Peak expiratory flow (PEF) 1.1 2.5 3.6 1.9 -1.2
Pulse wave reflection index 0.9 1.1 1.3 1.1 -0.9
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.5 1.6 -0.4
Loud music exposure frequency 1.6 1.7 3.2 0.5 1.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.4 -0.6 -0.4
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.2 1.5 -0.2
Blood clot in the leg (DVT) 1.9 2.4 3.1 1.3 -1.8
Medication: Paracetamol 0.5 0.8 1.4 0.4 1.2
Headache pain in last month 0.6 1.1 2.0 0.5 -1.4
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.5 1.2 -0.9
Glaucoma (self-reported) 1.0 1.1 2.2 0.3 -1.5
Gout (self-reported) 0.1 0.1 0.1 0.3 0.4
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 4.2 0.7 2.0
Medication: Amlodipine 2.4 3.3 6.7 0.0 2.6
Medication: Ventolin 100micrograms inhaler 2.1 2.7 4.1 -2.0 1.2
Birth weight 0.1 0.3 0.4 0.4 -0.6
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.1 -1.1 -0.8
High blood pressure (siblings) 0.5 0.7 1.4 -0.2 -1.2
Forced vital capacity (FVC), Best measure 0.8 2.9 5.5 0.5 -2.3
Body fat percentage 0.0 0.1 0.2 -0.1 -0.5
Leg fat percentage (right) 0.0 0.2 0.2 0.4 -0.4
Arm fat-free mass (right) 0.1 0.7 1.5 0.2 1.2
Exposure to tobacco smoke outside home 0.2 0.2 0.4 -0.2 -0.6
Comparative body size at age 10 0.6 1.7 3.0 0.7 -1.7
Number of full brothers 0.1 0.2 0.3 -0.5 -0.2
Worry too long after embarrassment 0.9 1.6 3.2 -0.0 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.5 -0.4 -1.2
Wheeze or whistling in the chest in last year 1.3 2.3 2.6 -1.4 1.6
Number of children fathered 0.5 0.6 0.8 0.9 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.0 1.0 -0.5
Age at first live birth 0.0 0.1 0.1 -0.3 -0.1
Pulse wave peak to peak time 0.7 0.8 0.9 -0.9 -0.8
Health satisfaction 1.4 1.8 2.9 0.8 1.7
Shortness of breath walking on level ground 0.3 0.4 0.7 0.9 0.1
Qualifications: College or University degree 1.2 3.8 6.2 1.2 2.5
Eye problems/disorders: None of the above 1.4 1.6 3.2 1.8 -0.3
Mouth/teeth dental problems: Loose teeth 4.0 4.7 6.0 -2.5 1.9
Emphysema/chronic bronchitis 0.3 0.4 0.7 -0.0 0.8
Medication for pain relief, constipation, heartburn 0.3 0.5 0.5 -0.7 -0.7
Neck or shoulder pain in last month 0.7 1.1 2.0 1.4 -0.3
Medication: Blood pressure 1.1 2.0 2.6 -1.6 1.2
Angina (self-reported) 1.3 1.7 3.1 1.8 -0.6
Migraine (self-reported) 0.9 1.1 1.9 -1.4 -0.5
Medication: Ibuprofen 2.5 3.0 4.9 2.2 -1.0
Medication: Allopurinol 1.3 1.7 3.0 1.7 0.7
Medication: Omeprazole 0.5 0.5 1.0 -0.2 1.0
Medication: Seretide 50 evohaler 0.7 0.9 1.7 -0.2 1.3
Mean time to correctly identify matches 0.9 1.8 3.1 -1.8 -0.7
Heart disease (mother) 0.2 0.3 0.5 -0.7 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.3 0.6 -0.0
Whole body fat mass 0.0 0.1 0.2 -0.4 -0.2
Leg fat mass (right) 0.0 0.1 0.1 0.3 0.0
Arm predicted mass (right) 0.2 0.9 1.8 0.3 1.3
Pulse rate, automated reading 2.7 8.8 11.9 -3.5 -2.4
Alcohol intake frequency. 1.1 2.5 5.1 0.0 2.3
Comparative height size at age 10 0.1 0.7 1.2 0.5 -1.1
Number of full sisters 0.5 0.6 0.7 0.8 -0.7
Suffer from ‘nerves’ 0.2 0.4 0.5 -0.7 0.5
Overall health rating 0.3 0.6 0.7 -0.7 0.8
Chest pain or discomfort 1.6 2.3 4.6 -2.1 0.1
Had major operations 1.0 1.2 1.4 1.0 -1.2
Age at last live birth 0.1 0.1 0.1 0.4 0.3
Family relationship satisfaction 1.2 1.4 2.8 -1.7 0.2
Leg pain on walking 1.2 1.5 1.6 1.3 1.2
Qualifications: NVQ or HND or HNC or equivalent 2.6 3.2 4.4 -2.1 -1.4
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.5 -0.2 -0.7
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 1.4 -0.7 1.2
Medication: Aspirin 0.1 0.1 0.2 0.4 0.4
Supplements: Vitamin C 1.1 1.4 2.4 0.6 -1.5
Knee pain experienced in last month 0.1 0.1 0.1 -0.1 -0.4
Hypertension (Self-reported) 2.4 6.8 11.1 -1.6 3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 4.0 -0.1 2.0
Illnesses of father: Heart disease 0.9 1.2 1.5 1.2 0.9
Illnesses of siblings: Diabetes 2.4 2.9 4.9 -1.0 2.2
Smoking status: Previous 0.1 0.1 0.2 0.5 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 1.2 -0.5 -1.1
Whole body fat-free mass 0.0 0.2 0.4 0.1 0.6
Leg fat-free mass (right) 0.0 0.1 0.1 0.2 0.2
Arm fat percentage (left) 0.0 0.1 0.1 -0.1 -0.3
Average weekly red wine intake 0.3 0.5 0.8 0.4 -0.9
Handedness (chirality/laterality): Left-handed 1.9 2.3 2.7 1.4 1.6
Mood swings 0.3 0.6 1.1 0.1 1.1
Loneliness, isolation 0.5 0.7 1.1 1.1 0.6
Long-standing illness, disability or infirmity 0.1 0.2 0.2 -0.3 0.5
Ever had bowel cancer screening 1.6 1.9 3.7 -0.2 -1.9
Diabetes diagnosed by doctor 4.4 7.2 9.5 -2.2 3.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 0.3 -0.4
Friendships satisfaction 1.3 1.6 1.8 -1.4 1.2
Qualifications: nursing, teaching 0.1 0.2 0.2 0.5 0.5
Commuting to job workplace: Walk 0.4 0.4 0.8 0.9 -0.2
Eye problems/disorders: Cataract 0.2 0.2 0.3 -0.6 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 0.5 0.4
Medication for cholesterol 3.6 5.5 6.7 2.1 -2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.7 0.9 -0.7
Back pain experienced in last month 0.2 0.3 0.5 0.3 -0.7
Mineral and other dietary supplements 0.8 1.0 2.0 0.3 1.4
Breast cancer (self-reported) 1.3 1.6 2.7 -1.6 -0.7
Asthma (self-reported) 0.4 0.8 1.0 -1.0 0.8
Osteoporosis (self-reported) 3.3 4.1 6.8 1.1 -2.6
Osteoarthritis (self-reported) 1.8 2.3 4.0 0.8 2.0
Medication: Aspirin 0.3 0.3 0.6 0.3 0.8
Medication: Gliclazide 3.3 3.7 3.8 -2.0 1.9
Illnesses of father: None of the above (group 1) 4.6 5.7 9.9 -1.2 -3.1
Smoking status: Current 0.4 0.6 1.1 -1.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.7 0.7 -1.3
Whole body water mass 0.1 0.3 0.5 0.3 0.7
Leg predicted mass (right) 0.0 0.1 0.1 0.2 0.3
Arm fat mass (left) 0.0 0.2 0.2 -0.4 0.4
Number of self-reported non-cancer illnesses 1.2 2.2 4.3 -2.1 0.2
Average weekly champagne plus white wine intake 1.6 2.3 4.5 -0.1 -2.1
Miserableness 0.6 1.1 2.2 -0.2 1.5
Guilty feelings 0.9 1.3 1.7 1.3 -1.0
Wears glasses or contact lenses 0.8 0.9 1.6 -1.3 0.3
Ever taken oral contraceptive pill 1.0 1.1 1.8 1.4 0.6
Hearing aid user 0.8 0.9 1.7 -1.3 0.2
Mother’s age at death 3.1 3.9 7.6 2.8 0.5
Financial situation satisfaction 0.5 0.6 1.2 1.1 0.3
Tinnitus: Yes, now most or all of the time 1.2 1.4 2.8 -0.2 -1.7
Commuting to job workplace: Public transport 1.3 1.5 1.8 1.1 1.4
Eye problems/disorders: Glaucoma 1.3 1.6 2.2 -1.0 -1.5
Medication: Blood pressure 5.3 10.0 18.9 -1.1 4.3
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.4 0.1
Supplements: Fish oil (including cod liver oil) 1.3 1.7 1.8 -1.2 -1.3
High cholesterol (Self-reported) 0.4 0.7 1.2 -0.3 1.1
Medication: Bendroflumethiazide 1.0 1.4 2.9 -0.2 1.7
Medication: Paracetamol 0.4 0.6 0.9 0.6 0.9
Medication: Lisinopril 3.1 4.0 5.5 -1.6 2.4
Medication: Atorvastatin 0.3 0.4 0.8 0.2 0.9
Illnesses of father: High blood pressure 2.6 3.3 6.6 0.1 2.6
Alcohol drinker status: Never 0.1 0.1 0.1 0.4 -0.2
Ever smoked 0.0 0.0 0.1 0.2 -0.1
Basal metabolic rate 0.0 0.2 0.3 0.1 0.5
Leg fat percentage (left) 0.0 0.1 0.1 0.3 0.0
Arm fat-free mass (left) 0.3 1.4 2.6 0.3 1.6
Number of operations (self-reported) 0.3 0.4 0.7 -0.8 0.4
Average weekly beer plus cider intake 0.0 0.0 0.0 0.2 -0.1
Irritability 0.6 1.0 1.1 1.0 -1.1
Risk taking 0.5 0.7 0.8 0.9 -0.8
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.0 0.3 -1.7
Fractured/broken bones in last 5 years 0.7 0.9 1.2 0.7 -1.1
Age started oral contraceptive pill 0.0 0.0 0.0 -0.2 0.2
Diastolic blood pressure, automated reading 2.2 6.7 9.3 -2.0 3.0
Ever depressed for a whole week 0.5 0.6 0.6 -0.7 -0.8
Unable to work because of sickness or disability 0.5 0.6 1.1 -1.1 -0.3
Commuting to job workplace: Cycle 2.5 3.0 5.9 2.4 0.3
Myopia 0.3 0.4 0.5 0.7 0.5
Vascular/heart problems diagnosed by doctor 1.4 3.8 6.7 1.0 -2.6
Cholesterol lowering medication 3.1 4.6 8.0 -1.1 2.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.6 -0.3 0.8
Pain experienced in last month 0.6 1.1 2.0 -1.4 -0.4
Supplements: Calcium 1.6 1.8 2.6 -1.0 -1.6
Basal cell carcinoma (self-reported) 0.8 1.0 1.8 1.3 0.4
Heart attack/myocardial infarction (self-reported) 2.0 2.6 4.9 2.2 -0.5
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 2.9 1.7 -1.6
Heart disease (siblings) 0.3 0.4 0.5 -0.7 0.5
Alcohol drinker status: Previous 2.5 2.9 2.9 1.7 1.7
Pack years of smoking 1.0 1.4 2.8 0.0 1.7
Impedance of whole body 0.4 1.9 2.8 -1.0 -1.7
Leg fat mass (left) 0.0 0.1 0.1 0.4 0.3
Arm predicted mass (left) 0.2 1.1 2.2 0.3 1.5