Hub : Genes

STK38L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0680 0.0280 0.00140 0.002 0.021 0.019 0.020 0.008 1.6e-01 0.0012 1.8e-03 0.0014 3.5e-02
2 GTEx Brain Cerebellar Hemisphere 0.2950 0.0910 0.00067 0.104 NA 0.155 NA 0.243 1.3e-03 NA 8.7e-05 NA 6.3e-07
3 GTEx Brain Nucleus accumbens basal ganglia 0.2550 0.0830 0.00120 -0.008 NA 0.076 NA 0.041 6.0e-01 NA 4.5e-03 NA 3.0e-02
4 GTEx Brain Putamen basal ganglia 0.2790 0.1020 0.00670 0.078 NA 0.014 NA 0.049 6.7e-03 NA 1.4e-01 NA 2.6e-02
5 GTEx Pancreas 0.1910 0.0740 0.00420 0.070 NA 0.057 NA 0.113 6.9e-04 NA 2.1e-03 NA 1.7e-05
6 METSIM Adipose 0.0414 0.0183 0.01000 0.035 0.008 0.015 0.009 0.026 4.1e-06 0.0200 2.1e-03 0.0150 7.2e-05
7 TCGA Thyroid Carcinoma 0.0560 0.0280 0.00440 0.000 0.006 0.000 NA -0.003 3.6e-01 0.0820 3.1e-01 NA 7.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.6 2.3 0.7 1.5 0.1 0.3 -0.8 -0.5 -0.2
Bipolar Disorder or Schizophrenia 0.4 1.0 2.0 -0.6 1.2 -1.1 -0.8 -1.2 0.4 -1.4
Depressed Affect (Nagel 2018) 0.7 1.4 3.3 -1.8 -0.8 -1.1 -1.0 -1.6 -1.1 0.2
Depression (Nagel 2018) 0.4 0.6 1.5 -1.0 -0.2 -0.3 -1.2 -1.1 0.1 -0.1
Intelligence (Savage-Jansen 2018) 0.1 0.3 1.7 0.4 0.2 0.6 -0.3 0.2 0.1 -1.3
Neuroticism (Nagel 2018) 0.4 0.9 2.4 -1.2 0.4 -0.3 -1.0 -1.5 -0.5 -1.2
Schizophrenia (2018) 0.7 1.4 2.7 -1.3 0.3 -1.5 -1.3 -0.9 1.0 -1.6
Schizophrenia vs Biploar Disorder 0.3 0.3 1.7 -0.6 -0.4 -0.3 -1.3 0.2 0.1 -0.1
Worry (Nagel 2018) 0.3 0.6 1.8 -0.6 1.1 0.1 -0.4 -0.7 0.2 -1.3
Alzheimer’s Disease (in mother) 1.1 1.2 3.1 1.8 0.9 0.4 1.0 0.9 1.5 -0.7
Alzheimer’s Disease (in father) 1.4 1.5 3.4 0.5 -0.5 -1.0 -1.8 -1.5 -1.7 -0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.7 1.3 0.9 -0.7 0.1 0.1 0.6 -1.1
Crohns Disease (2017) 0.8 1.8 5.6 -0.7 1.5 1.6 2.4 0.5 1.1 0.3
Irritable Bowel Disease (IBD) 0.6 1.5 4.3 0.1 1.2 2.1 1.9 -0.1 -0.2 -1.0
Ulcerative Colitis (UC) 0.9 1.6 4.4 0.6 0.6 2.1 0.7 -0.7 -1.4 -1.8
Major Depression (MDD) 0.4 0.5 0.9 -0.6 -1.0 -0.6 -0.6 -0.7 -0.3 0.7
Reaction Time 0.4 0.7 1.1 1.1 -0.6 1.0 0.9 1.1 0.5 0.7
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.9 0.1 1.0 0.5 0.1 -0.5 0.3 -0.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.3 1.7 4.9 -0.5 -1.6 -0.0 -2.2 -0.6 -0.6 1.9
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.8 1.2 3.0 0.2 1.7 1.5 0.1 1.2 -0.7 -1.1
Bipolar Disorder (2011) 0.2 0.2 0.4 0.5 -0.3 0.2 0.2 -0.1 0.7 -0.5
Body Mass Index (BMI) (2010) 1.4 1.9 4.7 -2.2 -1.8 -0.5 -1.0 -1.1 -1.1 1.1
Coronary Artery Disease (CAD) 0.9 1.1 5.4 -0.4 0.5 0.4 2.3 0.2 1.3 -0.5
Crohns Disease (2012) 0.5 0.8 1.4 -1.0 1.2 1.1 1.2 -0.2 0.9 0.4
Mean Putamen Volume 1.4 1.6 6.2 -0.9 2.5 -0.5 0.1 1.5 1.1 0.5
Fasting Glucose 0.5 0.5 2.2 -0.3 -1.5 -0.3 -1.0 -0.2 -0.5 -0.2
HbA1C 0.4 0.5 1.1 -0.1 -1.0 0.8 -0.4 0.2 -0.5 1.0
HDL Cholesterol 0.1 0.2 0.7 0.8 0.4 -0.2 -0.0 0.1 0.8 -0.1
LDL Cholesterol 1.2 1.9 4.4 -1.8 -1.1 -0.5 -1.1 -2.1 -1.7 -0.6
Lupus 0.3 0.4 1.4 -0.7 0.1 -0.9 -0.1 -1.2 -0.0 0.5
Neuroticism (2016) 0.5 0.8 2.0 0.1 -0.3 -1.0 -1.4 0.2 -1.4 0.3
Primary Biliary Cirrhosis 0.4 0.6 1.5 1.0 -1.2 0.3 0.8 0.6 0.6 -0.2
Rheumatoid Arthritis 0.2 0.2 0.8 0.9 -0.4 0.2 -0.0 0.2 -0.3 -0.7
Schizophrenia (2014) 0.5 1.1 4.4 -0.6 0.8 -0.8 -0.7 -0.9 0.4 -2.1
Triglycerides 0.7 1.1 3.0 0.6 -1.7 0.2 -0.4 1.0 -0.3 1.7
Type 2 Diabetes (T2D) (2012) 1.4 1.6 6.4 -1.0 0.2 -1.7 0.0 -2.5 -0.8 0.4
Ulcerative Colitis 1.0 1.4 3.3 -0.3 -0.0 1.2 -0.1 -1.8 -1.5 -1.7
Blood Eosinophil Count 0.2 1.8 6.2 -0.5 -1.5 -0.8 0.1 -0.8 2.5 1.6
Blood Platelet Count 0.3 3.0 10.3 -1.5 -3.2 -1.9 -0.6 -0.4 2.0 0.5
Blood Red Count 0.2 1.9 5.8 -1.5 0.4 2.4 2.0 0.4 1.0 0.0
Blood White Count 0.5 3.9 9.2 1.5 -0.7 1.0 2.8 3.0 1.7 1.9
Heel T-Score 0.9 7.5 29.7 1.7 1.4 2.5 5.5 1.5 2.9 -0.8
BMI 1.0 5.6 10.6 -3.2 -1.8 -1.8 -2.2 -1.8 -2.8 2.6
Height 0.2 4.7 17.0 1.4 2.2 4.1 0.1 0.2 1.8 -2.4
Waist Hip Ratio (WHR) 2.4 10.9 30.2 3.1 1.5 0.4 5.5 3.2 4.7 1.4
Systolic Blood Pressure 0.6 3.2 10.0 -0.7 -3.2 -1.2 0.4 -1.5 -0.6 2.7
Smoking Status 0.2 0.5 2.0 0.8 0.2 -0.4 -0.1 0.7 0.1 1.4
Allergy or Eczema 0.7 1.9 4.4 1.8 1.5 1.4 0.1 0.2 1.1 -2.1
Cardiovascular Disease 0.3 1.0 3.5 0.0 -0.9 0.5 1.9 -0.5 -1.3 0.7
Hypothyroidism (self reported) 0.9 2.0 5.6 -1.0 -1.4 -1.9 -1.4 -0.2 0.5 2.4
Respiratory disease 1.1 2.5 9.0 1.7 0.8 1.8 1.1 -0.3 0.4 -3.0
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.6 -0.1 0.1 -1.6 1.0 -0.9 0.5 1.3
Lung FEV1/FVC ratio 0.6 2.8 14.1 -0.4 -1.3 -1.2 0.7 1.0 0.9 3.8
Lung FVC 0.5 2.5 8.9 -0.8 1.2 -0.5 -1.8 -0.6 -1.7 -3.0
Neuroticism 0.2 0.6 2.0 -0.1 1.4 0.6 -0.3 -0.3 0.6 -1.0
Chronotype (morning person) 0.7 1.6 5.6 -1.2 -0.7 0.8 1.3 -2.4 0.1 -1.0
Hair Pigment 0.2 5.4 14.4 -2.6 -0.4 -3.4 -1.5 -1.2 1.1 3.8
Tanning 0.1 0.7 3.4 0.3 -1.8 -0.1 0.1 0.1 -1.1 -0.3
Hand grip strength (left) 0.2 0.6 2.0 -0.7 0.0 0.7 -0.9 -1.4 0.4 -0.7
Number of treatments/medications taken 0.4 0.7 4.0 -0.0 0.5 0.1 2.0 0.0 0.9 -0.1
Average weekly spirits intake 1.2 1.5 2.8 1.7 1.1 0.0 1.7 1.3 1.6 0.2
Sensitivity / hurt feelings 0.8 1.3 4.5 -0.1 2.1 1.0 0.4 -0.9 0.1 -1.7
Frequency of depressed mood in last 2 weeks 0.5 0.8 2.4 -1.3 -0.3 -0.3 -1.5 -0.9 0.4 0.4
Hearing difficulty/problems: Yes 0.5 0.8 2.9 0.9 1.7 0.6 0.3 1.0 0.0 0.6
Relative age of first facial hair 1.2 2.5 8.5 2.1 2.9 0.8 1.5 0.7 -0.9 -0.6
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 3.2 1.2 1.7 1.4 0.3 0.5 -0.8 -1.8
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.6 0.7 0.4 1.5 1.6 1.6 1.4 -0.1
Ever had hysterectomy (womb removed) 0.5 0.6 1.6 0.4 0.0 0.1 1.3 0.5 1.1 -0.8
Systolic blood pressure, automated reading 1.0 2.9 12.2 -1.3 -1.4 -1.2 -0.3 -0.6 -1.5 3.5
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.9 0.0 1.0 -0.1 -0.2 -0.4 -0.6 0.5
Angina 1.3 1.7 4.7 -2.2 -1.8 -0.2 -0.3 -1.2 0.4 1.5
Medication for hormone replacement therapy 0.3 0.4 1.1 0.6 -0.2 -0.9 0.2 0.2 1.0 0.6
Vitamin and mineral supplements 0.8 1.0 4.4 2.1 -0.7 1.0 0.6 0.9 -0.6 0.2
Supplements: Zinc 0.5 0.5 2.3 -0.1 -0.4 -0.0 -1.0 0.1 -1.5 0.2
Medication: Co-codamol 2.3 2.7 6.9 0.8 -2.0 -1.7 -0.8 1.6 -1.1 2.6
Medication: Metformin 0.7 1.0 2.7 1.2 1.1 -0.8 1.6 0.3 0.4 1.1
Diabetes (father) 0.9 1.1 1.7 1.3 -1.3 -1.2 0.9 -0.6 1.2 0.7
Diabetes (mother) 1.2 1.5 3.2 1.7 -0.5 1.8 0.5 1.5 0.5 1.3
Severe depression (siblings) 0.9 1.0 3.5 -0.3 -0.9 -0.8 -1.9 -1.0 -1.0 0.2
Pack years adult smoking proportion 0.7 1.0 1.9 -0.8 -1.4 -1.1 -0.5 -1.0 0.0 1.4
Impedance of leg (right) 1.1 5.1 10.7 3.3 0.9 2.8 2.4 2.5 2.0 -0.6
Leg fat-free mass (left) 0.3 1.8 4.2 -2.0 -1.4 -0.6 -2.0 -1.2 -0.8 0.4
Trunk fat percentage 0.5 1.8 4.1 -0.8 -1.5 1.2 -0.8 0.8 -1.7 2.0
Hand grip strength (right) 0.1 0.4 1.3 -0.3 1.0 -0.1 -0.1 -0.6 1.1 0.0
Townsend deprivation index at recruitment 0.9 1.3 4.4 -1.3 -0.7 -1.4 -0.6 -0.4 0.5 2.1
Current tobacco smoking 0.5 0.9 2.2 -0.5 0.4 -1.5 0.3 -1.1 -0.4 1.4
Average weekly fortified wine intake 0.9 1.0 3.2 -0.8 1.8 0.1 0.2 -1.4 -0.5 -0.9
Maternal smoking around birth 0.8 1.2 3.3 -1.4 -1.4 0.1 1.0 -0.1 0.6 1.8
Fed-up feelings 0.6 1.1 3.1 -1.8 -0.8 0.3 -0.9 -0.8 -1.3 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.7 -1.3 -0.2 -0.7 -0.9 -0.5 0.0 0.7
Relative age voice broke 1.2 1.9 3.6 0.9 1.5 1.7 1.7 0.1 0.9 -1.9
Taking other prescription medications 0.6 0.9 2.6 0.6 -0.5 0.7 1.0 -1.6 -0.7 -1.0
Age when periods started (menarche) 0.8 2.0 6.6 2.6 1.3 0.5 1.4 1.4 1.2 -0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.7 -1.0 -1.6 -0.3 -0.9 -0.6 -0.5 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 3.7 0.5 1.9 0.7 1.6 -1.4 -0.0 -1.7
Tinnitus: Yes, but not now, but have in the past 2.9 3.1 6.9 -2.2 -1.9 -1.9 -1.6 -2.6 0.2 -0.1
Qualifications: CSEs or equivalent 5.0 6.6 13.2 -2.8 -2.2 -3.6 -3.0 -1.0 0.9 3.2
Serious illness, injury or assault to yourself 1.8 2.2 4.3 -0.8 -2.0 -1.6 -1.1 -1.6 2.1 0.4
High blood pressure 0.3 0.9 2.9 -0.8 -0.6 -0.2 1.7 -1.4 -0.7 0.4
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.8 1.5 1.3 0.4 -0.1 0.0 1.1 -1.9
Multivitamins +/- minerals 1.6 2.1 5.4 -2.3 -0.6 -2.0 -0.3 -2.0 1.0 0.2
Stomach or abdominal pain in last month 1.4 1.7 4.7 -0.8 -0.8 -2.2 -1.4 0.3 0.8 1.9
Supplements: Glucosamine 0.6 0.8 3.1 0.9 1.7 0.5 0.3 0.7 -0.1 -0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 2.9 -0.1 0.6 -0.1 -0.6 0.5 -0.1 1.7
Medication: Atenolol 0.9 1.1 4.4 0.1 0.4 -0.1 2.1 -1.3 0.4 -1.1
Medication: Levothyroxine sodium 0.4 0.8 3.0 -0.7 -0.8 -0.6 -0.7 0.5 -0.4 1.7
Sitting height 0.2 1.6 7.0 0.6 0.7 2.6 -0.0 0.4 1.0 -1.5
Chronic bronchitis/emphysema (father) 0.3 0.4 0.9 -0.7 -0.6 -0.3 -0.8 -0.0 1.0 0.6
High blood pressure (mother) 1.0 1.5 4.2 -1.4 -0.8 -2.1 -1.3 -1.3 -0.3 -0.2
Body mass index (BMI) 0.8 3.5 5.9 -2.4 -1.8 -1.7 -1.6 -1.1 -2.1 2.1
Impedance of leg (left) 1.1 5.3 10.0 3.0 1.0 3.2 2.7 2.3 2.0 -0.5
Leg predicted mass (left) 0.4 2.0 4.4 -2.0 -1.5 -0.6 -2.1 -1.3 -0.9 0.4
Trunk fat mass 0.4 1.5 3.4 -1.2 -1.4 0.9 -1.0 0.4 -1.4 1.9
Waist circumference 0.3 0.9 3.7 -0.7 -1.2 -0.6 0.5 0.3 -0.3 1.9
Number of incorrect matches in round 1.0 1.7 4.1 -2.0 2.0 -0.4 0.7 -1.1 1.4 0.5
Past tobacco smoking 0.5 0.9 2.3 -1.2 0.6 -1.5 0.7 -0.6 1.2 -0.1
Alcohol usually taken with meals 0.4 0.7 1.7 0.9 0.3 1.1 0.1 1.3 -0.9 0.5
Nervous feelings 0.7 1.2 2.8 -0.9 1.6 -0.8 -1.7 -1.1 -0.2 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.0 -1.0 0.1 -0.8 -0.2 -0.1 0.4 0.6
Hearing difficulty/problems with background noise 0.3 0.5 1.7 0.0 1.1 0.1 -0.1 -0.9 -1.3 0.5
Hair/balding pattern: Pattern 2 0.4 0.6 2.5 -0.5 0.1 -1.6 -0.3 -0.3 0.5 0.8
Had menopause 0.8 1.0 2.8 0.6 0.1 1.2 -0.8 1.7 0.5 1.2
Had other major operations 0.6 0.7 1.3 -0.5 -0.6 1.0 -1.1 0.8 0.4 1.1
Forced vital capacity (FVC) 0.5 1.9 8.1 -0.5 1.4 1.3 -0.8 0.2 -0.5 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 4.0 0.8 2.0 1.4 2.0 -0.2 -0.1 -1.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.3 -0.0 -1.3 -0.1 0.0 -1.5 0.6 -0.7
Qualifications: None of the above 2.1 4.6 10.5 -2.8 -2.1 -2.4 -1.7 0.2 0.4 3.2
Financial difficulties in last 2 years 3.2 4.3 9.1 -2.0 -3.0 -2.1 -1.7 -2.9 -1.0 0.0
Mouth/teeth dental problems 0.5 0.7 2.2 0.8 0.6 0.9 0.2 1.5 0.5 0.9
Heart attack 0.6 0.7 1.9 -1.1 0.0 1.1 1.4 -0.5 0.3 -0.7
Allergy 0.5 1.3 4.8 -1.3 -0.8 -0.6 -0.3 0.8 -0.8 2.2
Pain all over the body in last month 0.8 0.8 2.8 0.2 0.1 -1.7 -0.6 -1.5 -0.3 -0.5
Diabetes (self-reported) 0.4 0.7 1.7 0.7 0.2 -1.0 1.0 -1.3 0.5 0.7
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 8.2 2.9 1.4 1.0 -0.0 1.6 -0.3 -0.9
Medication: Ramipril 0.5 0.6 1.7 -0.4 -0.3 0.2 1.3 -1.2 -0.1 -0.8
Medication: Simvastatin 0.7 1.0 5.7 0.5 0.4 -0.9 0.2 0.2 -0.5 2.4
Fluid intelligence score 0.9 1.8 4.5 0.4 1.5 1.6 1.6 -0.1 0.3 -2.1
Illnesses of siblings 1.5 2.1 6.0 -0.7 -1.6 0.4 -1.4 -2.4 -1.1 -1.4
Neuroticism score 0.3 0.7 1.9 -0.4 1.4 0.3 -0.5 -0.9 0.5 -1.3
Weight 0.3 1.3 2.1 -1.5 -1.3 0.2 -1.4 -0.7 -1.3 1.2
Impedance of arm (right) 0.5 2.4 7.9 2.2 -0.3 2.8 0.6 1.9 0.5 -0.0
Arm fat percentage (right) 0.6 2.5 5.8 -1.5 -1.8 -0.3 -1.3 0.1 -2.0 2.4
Trunk fat-free mass 0.1 0.3 1.1 -0.7 -0.3 -0.2 -1.1 -0.8 0.1 -0.2
Hip circumference 0.8 3.6 7.5 -2.7 -1.5 -0.7 -2.3 -1.0 -2.6 1.3
Time employed in main current job 2.1 2.4 5.3 2.0 -0.7 2.3 0.9 1.2 0.2 -2.2
Alcohol intake versus 10 years previously 0.3 0.5 1.7 -0.7 -1.3 -0.7 0.1 0.3 0.3 0.6
Father’s age at death 1.1 1.5 3.0 1.7 1.1 1.5 1.4 1.1 0.3 -0.8
Worrier / anxious feelings 0.2 0.3 1.0 -0.1 0.4 0.5 -0.5 -0.4 0.7 -1.0
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 7.6 -2.8 -1.0 -0.8 -1.1 -2.1 0.1 0.3
Falls in the last year 1.0 1.4 6.4 -0.4 -0.0 -1.2 0.0 -2.5 -0.5 -1.3
Hair/balding pattern: Pattern 3 0.4 0.5 1.3 1.0 -0.8 -0.2 -0.2 1.1 0.5 0.7
Number of live births 1.1 1.6 3.8 -0.3 -0.8 -1.9 -1.7 -0.2 -1.2 1.4
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 4.1 -0.6 0.5 0.5 -0.8 0.1 -0.6 -2.0
Pulse rate 0.3 0.5 1.3 -0.4 0.8 -0.4 0.2 1.1 -0.3 0.9
Happiness 0.8 1.0 3.6 -0.5 0.2 1.4 0.3 -0.4 -1.0 -1.9
Noisy workplace 1.2 1.5 6.3 0.6 0.6 -1.0 1.3 0.5 2.5 0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.9 -0.3 1.6 0.7 0.6 -2.0 -0.7 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 2.0 0.5 0.5 -0.3 0.1 0.8 1.4 -0.1
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 0.6 -0.7 0.9 0.3 0.6 0.2 0.3
Asthma 0.8 1.6 4.4 0.6 0.1 1.6 1.3 -1.4 0.2 -2.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 6.4 -2.5 0.2 -0.5 0.4 0.2 -0.2 0.4
Medication: Cholesterol lowering 0.5 0.8 1.5 1.2 0.6 0.4 1.1 0.7 -0.6 1.2
Depression (self-reported) 0.8 1.0 3.4 -1.9 0.2 0.5 -0.9 -0.9 -1.2 -0.6
Medication: Lansoprazole 1.8 2.1 4.1 -1.8 -1.4 -1.4 -2.0 -1.3 -1.0 0.7
Prospective memory result 0.6 0.8 1.3 -1.1 0.6 -1.0 -0.6 -0.9 0.4 1.2
Lung cancer (father) 0.1 0.2 0.7 -0.8 0.4 -0.2 -0.2 -0.4 -0.1 -0.4
Illnesses of mother 0.5 0.6 1.5 -0.7 -0.6 0.2 0.4 1.2 1.1 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.1 -0.9 1.4 0.3 -0.1 -0.1 0.2 -1.5
Pulse wave Arterial Stiffness index 1.4 1.6 6.9 -0.2 0.5 0.2 1.8 0.4 2.6 -0.9
Impedance of arm (left) 0.4 2.0 7.6 1.6 0.1 2.8 0.4 1.6 0.9 -0.4
Arm fat mass (right) 0.6 2.5 4.1 -2.0 -1.7 -0.6 -1.6 -0.6 -1.8 2.0
Trunk predicted mass 0.1 0.3 1.1 -0.6 -0.3 -0.2 -1.1 -0.8 0.1 -0.2
Standing height 0.3 2.9 12.5 1.4 0.9 3.5 0.1 0.6 1.6 -1.4
Length of working week for main job 4.9 5.5 10.3 -2.1 -2.6 -3.2 -3.0 -2.3 -1.5 0.4
Exposure to tobacco smoke at home 1.0 1.2 4.2 -0.2 -0.9 -2.1 -0.9 -0.6 0.0 1.4
Breastfed as a baby 0.8 1.0 3.8 0.6 -0.1 -0.3 0.6 1.9 0.6 1.3
Tense / ‘highly strung’ 0.5 0.9 2.1 0.1 0.1 -0.9 -1.0 -1.1 1.5 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 8.0 -2.6 0.3 -0.9 -1.1 -2.8 -0.1 -1.0
Hair/balding pattern: Pattern 4 0.4 1.1 3.5 -1.2 0.4 1.9 0.0 0.2 -1.5 -0.3
Birth weight of first child 1.6 2.9 12.3 0.8 3.5 2.1 -0.1 0.7 -1.1 -1.2
Peak expiratory flow (PEF) 0.4 1.0 2.0 -1.3 -1.3 -0.3 -0.6 -0.7 -0.6 -1.4
Pulse wave reflection index 3.2 3.9 8.4 1.7 1.3 0.7 2.7 1.1 2.9 -2.4
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.7 -1.6 0.1 -0.3 -1.4 -0.7 -0.8 0.0
Loud music exposure frequency 0.6 0.7 1.5 0.7 -1.1 -0.3 1.2 -1.0 0.5 -0.1
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.3 0.2 -0.9 -1.0 -1.0 -1.1 -1.1 -0.5
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.9 -1.3 -1.4 -2.0 -1.1 -1.8 -0.9 0.0
Blood clot in the leg (DVT) 1.1 1.4 4.5 -0.4 -0.4 -0.9 -1.7 1.0 -0.3 2.1
Medication: Paracetamol 0.7 1.2 5.1 -2.3 1.0 -0.7 0.6 -0.6 1.1 -0.1
Headache pain in last month 0.6 1.1 3.6 -1.9 0.7 0.3 -0.5 -0.2 -1.5 -1.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 1.3 -0.4 0.3 -0.8 -1.1 0.2 0.5 -0.9
Glaucoma (self-reported) 0.3 0.4 1.3 -0.1 0.5 -0.6 0.4 0.6 0.4 -1.1
Gout (self-reported) 0.6 0.9 3.7 1.9 -0.0 -0.5 0.1 1.0 1.1 0.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 3.6 -0.5 -1.3 -1.1 -1.0 0.1 0.2 1.9
Medication: Amlodipine 2.7 3.8 7.2 -2.6 -2.4 -0.2 -0.7 -2.7 -2.4 1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.9 0.2 -0.8 -0.1 0.1 -0.9 0.8 -0.4
Birth weight 0.5 1.0 2.8 0.4 1.1 1.2 0.6 1.7 0.8 0.5
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.6 -0.3 1.1 0.9 0.5 -0.3 -1.3 -0.9
High blood pressure (siblings) 0.3 0.4 0.7 -0.6 0.6 -0.8 0.4 0.9 -0.2 0.5
Forced vital capacity (FVC), Best measure 0.4 1.6 4.7 -0.9 2.1 1.2 -0.4 -0.4 -0.2 -2.2
Body fat percentage 0.4 1.7 4.4 -1.0 -1.5 1.0 -0.7 0.7 -1.6 2.1
Leg fat percentage (right) 0.3 0.9 3.6 -0.5 -0.9 0.5 0.1 1.0 -0.7 1.9
Arm fat-free mass (right) 0.2 1.0 2.6 -1.6 -0.8 -0.6 -1.4 -1.0 -0.0 0.4
Exposure to tobacco smoke outside home 0.4 0.5 2.2 0.6 -0.1 -1.5 0.0 -0.0 0.9 0.2
Comparative body size at age 10 0.2 0.6 1.8 -1.4 -1.0 -0.6 0.2 -0.7 0.4 0.6
Number of full brothers 1.8 2.2 4.1 -1.8 -2.0 -1.7 -1.9 -0.8 0.6 1.0
Worry too long after embarrassment 0.8 1.3 2.7 1.6 1.5 1.4 -0.5 1.1 0.7 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.3 9.0 -2.4 0.2 -1.6 -1.7 -3.0 -1.8 -0.5
Wheeze or whistling in the chest in last year 0.4 0.6 1.2 0.8 -0.8 -0.8 0.9 0.1 1.1 0.7
Number of children fathered 0.5 0.6 1.7 0.7 0.1 0.3 0.3 -1.1 -0.8 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 2.8 3.3 7.3 1.6 2.2 1.5 2.2 0.1 1.0 -2.7
Age at first live birth 1.2 2.2 5.8 0.9 1.2 2.4 0.7 1.8 1.3 -1.3
Pulse wave peak to peak time 1.3 1.5 6.2 0.3 -0.3 0.2 -1.9 -0.3 -2.5 0.7
Health satisfaction 3.0 3.8 9.7 -3.1 -1.5 -2.0 -1.6 -2.2 -1.0 1.7
Shortness of breath walking on level ground 1.1 1.3 3.2 -1.4 -1.8 -0.1 0.0 -1.8 0.8 -0.4
Qualifications: College or University degree 1.7 5.2 8.1 2.2 2.8 2.8 2.4 1.8 1.7 -1.9
Eye problems/disorders: None of the above 0.4 0.4 1.5 0.3 -1.2 0.6 -0.7 0.2 -0.3 0.6
Mouth/teeth dental problems: Loose teeth 1.3 1.5 5.2 -2.3 -0.3 -1.6 -1.2 -0.9 -0.1 0.4
Emphysema/chronic bronchitis 0.4 0.5 1.1 1.0 -0.4 0.0 -1.0 1.0 -0.2 -0.3
Medication for pain relief, constipation, heartburn 0.8 1.3 4.9 1.0 -0.7 -0.7 -2.2 -0.7 -1.4 -0.2
Neck or shoulder pain in last month 1.1 1.6 6.2 -2.5 0.7 0.1 0.2 0.6 -0.1 2.0
Medication: Blood pressure 0.5 1.0 2.2 -1.2 -0.4 1.0 1.0 -1.5 -0.5 0.8
Angina (self-reported) 1.0 1.3 4.0 -2.0 -1.5 0.2 -0.0 -1.1 0.2 1.3
Migraine (self-reported) 0.3 0.4 1.3 0.8 0.3 0.7 1.1 0.5 0.3 -0.1
Medication: Ibuprofen 1.0 1.2 6.1 -2.5 0.2 -1.2 0.7 0.2 -0.0 0.6
Medication: Allopurinol 0.6 0.8 3.8 0.7 0.1 0.0 0.8 0.6 2.0 0.6
Medication: Omeprazole 0.2 0.3 0.6 0.5 -0.5 0.5 -0.7 -0.4 -0.6 0.1
Medication: Seretide 50 evohaler 1.1 1.2 5.3 2.3 0.8 1.1 1.0 -0.1 -0.6 0.4
Mean time to correctly identify matches 0.8 1.4 3.0 1.7 -0.5 1.1 1.4 1.6 0.9 0.7
Heart disease (mother) 0.7 0.9 2.0 1.0 0.9 0.4 1.4 0.7 -0.6 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 3.6 -1.0 -1.4 -1.9 -0.4 -0.1 -0.0 1.2
Whole body fat mass 0.4 1.8 3.6 -1.5 -1.6 0.3 -1.3 -0.2 -1.6 1.9
Leg fat mass (right) 0.3 1.3 3.4 -1.4 -1.5 -0.1 -0.8 -0.2 -0.8 1.8
Arm predicted mass (right) 0.2 1.2 2.9 -1.7 -0.8 -1.1 -1.5 -1.2 0.1 0.5
Pulse rate, automated reading 0.7 2.3 7.6 -1.4 0.6 -0.5 -0.3 2.8 1.2 2.0
Alcohol intake frequency. 0.6 1.3 3.0 -1.7 -1.7 -0.5 -1.1 -1.2 0.7 0.3
Comparative height size at age 10 0.3 1.6 4.8 -0.0 0.5 2.2 0.7 0.9 2.1 -0.3
Number of full sisters 2.5 3.1 5.5 -1.1 -2.2 -2.1 -1.9 -0.6 -1.2 2.3
Suffer from ‘nerves’ 0.7 1.1 2.9 -0.8 1.6 -0.1 0.6 -0.1 1.0 -1.7
Overall health rating 0.3 0.6 1.8 -0.7 -1.3 -0.9 -0.3 -0.8 -0.2 0.5
Chest pain or discomfort 2.1 3.0 6.6 -2.6 -1.2 -2.3 -1.3 -2.4 0.5 0.5
Had major operations 0.6 0.7 3.4 -1.0 -0.1 0.5 -0.0 -0.7 1.8 -0.3
Age at last live birth 0.5 0.7 3.5 0.5 0.9 0.4 -0.5 1.9 0.0 0.6
Family relationship satisfaction 0.6 0.7 3.8 0.3 -0.2 0.8 -0.1 -0.5 -0.1 -2.0
Leg pain on walking 1.4 1.8 8.9 -0.9 -1.0 -3.0 -0.2 -1.2 0.4 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.1 0.5 1.0 -0.1 0.7 0.1 1.0 -0.5
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.1 -0.5 -0.3 0.3 -0.2 -0.7 -1.0 -0.2
Illness, injury, bereavement, stress in last 2 years 2.7 3.3 5.7 2.4 2.0 2.3 2.1 1.8 -0.2 -0.4
Medication: Aspirin 0.5 0.7 1.4 0.9 -1.2 0.1 1.2 0.3 0.9 0.3
Supplements: Vitamin C 1.3 1.6 3.7 -1.7 1.5 -0.6 -1.9 0.9 -1.0 0.2
Knee pain experienced in last month 0.3 0.5 1.6 -1.3 0.3 0.6 0.3 -0.8 -0.7 -0.0
Hypertension (Self-reported) 0.3 0.8 3.2 -0.4 -0.5 0.1 1.8 -1.1 -0.6 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.2 0.4 0.3 0.0 0.6 -1.0 -0.0 -1.5
Illnesses of father: Heart disease 0.4 0.6 1.9 -0.2 -0.0 0.4 1.4 -1.0 1.0 -0.4
Illnesses of siblings: Diabetes 1.0 1.2 4.5 2.1 1.4 -0.7 0.4 0.9 0.5 0.4
Smoking status: Previous 0.5 0.7 3.0 0.6 -1.0 1.7 -0.4 0.6 -0.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 7.5 -1.6 0.5 0.9 0.9 -0.0 2.7 0.1
Whole body fat-free mass 0.1 0.8 2.2 -1.2 -0.8 -0.4 -1.5 -1.0 -0.3 0.1
Leg fat-free mass (right) 0.4 2.2 5.0 -2.2 -1.5 -0.5 -2.1 -1.5 -0.9 0.4
Arm fat percentage (left) 0.7 2.9 5.9 -2.1 -1.8 -0.4 -1.7 -0.1 -1.9 2.4
Average weekly red wine intake 0.8 1.1 3.7 1.2 0.6 1.3 0.6 0.4 0.2 -1.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.9 0.5 0.2 -0.2 -0.2 -1.0 -0.8 -0.9
Mood swings 1.0 1.8 5.2 -2.3 -0.9 -1.0 -1.8 -1.4 -0.5 0.1
Loneliness, isolation 0.3 0.3 1.1 0.4 -0.4 -0.5 -0.4 0.7 0.5 1.0
Long-standing illness, disability or infirmity 1.3 2.1 5.6 -1.1 -2.4 -1.5 -0.9 -1.7 0.4 1.1
Ever had bowel cancer screening 0.3 0.3 1.1 -0.3 -1.1 -0.3 -0.1 -0.2 0.9 0.4
Diabetes diagnosed by doctor 0.5 0.8 1.5 0.6 0.1 -1.1 1.1 -1.2 0.9 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.7 0.4 1.3 0.3 0.7 1.0 -1.3 -0.1
Friendships satisfaction 0.4 0.4 0.8 0.9 0.5 0.5 -0.7 0.3 -0.7 -0.9
Qualifications: nursing, teaching 1.8 2.8 7.4 1.4 2.7 -0.4 1.6 -1.0 -1.3 -2.2
Commuting to job workplace: Walk 0.6 0.7 1.3 0.0 0.9 -0.9 0.6 -1.1 0.7 -1.0
Eye problems/disorders: Cataract 1.0 1.2 4.4 0.7 0.2 1.0 0.3 2.1 0.2 1.5
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.1 0.7 1.3 0.4 1.0 -0.2 -1.4 -1.5
Medication for cholesterol 0.8 1.2 2.5 -1.6 -1.1 0.5 -1.4 -1.4 0.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 3.3 -0.5 0.6 -0.3 1.8 0.3 1.7 0.5
Back pain experienced in last month 1.2 1.7 6.5 -1.6 -0.8 -1.2 -0.8 -0.2 -0.2 2.5
Mineral and other dietary supplements 0.3 0.5 2.1 -0.4 -0.3 0.8 1.5 -0.3 0.2 -0.2
Breast cancer (self-reported) 0.3 0.4 2.2 0.2 -0.1 1.5 -0.0 0.5 0.4 0.2
Asthma (self-reported) 0.8 1.5 4.4 0.3 0.2 1.5 1.1 -1.6 -0.0 -2.1
Osteoporosis (self-reported) 0.4 0.5 2.1 -0.4 -0.3 -0.5 -0.4 0.8 0.7 1.5
Osteoarthritis (self-reported) 1.0 1.3 3.6 -1.1 -0.4 -1.0 -0.6 1.2 1.1 1.9
Medication: Aspirin 0.6 0.8 3.1 0.9 -0.5 0.1 1.8 0.3 1.0 -0.2
Medication: Gliclazide 0.5 0.5 1.4 0.8 -0.5 -1.2 0.8 -0.3 -0.1 0.9
Illnesses of father: None of the above (group 1) 0.3 0.4 1.3 -0.1 0.8 0.7 -0.3 1.1 -0.6 -0.0
Smoking status: Current 0.4 0.7 1.7 -0.1 0.6 -1.3 0.5 -0.8 -0.5 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.8 -1.9 -0.2 -2.4 -1.6 -2.2 -1.0 -1.1
Whole body water mass 0.2 1.0 2.7 -1.4 -0.8 -0.6 -1.6 -1.1 -0.4 0.2
Leg predicted mass (right) 0.4 2.2 5.1 -2.3 -1.5 -0.6 -2.1 -1.6 -0.8 0.3
Arm fat mass (left) 0.6 2.7 4.9 -2.2 -1.6 -0.8 -1.7 -0.7 -1.8 2.0
Number of self-reported non-cancer illnesses 0.6 1.0 2.6 0.5 1.6 0.5 1.1 -0.9 -0.5 -1.2
Average weekly champagne plus white wine intake 0.1 0.1 0.2 0.3 -0.2 0.3 -0.2 0.0 0.5 -0.2
Miserableness 0.7 1.1 2.7 -1.3 -0.8 -0.6 -0.8 -1.6 -1.4 0.3
Guilty feelings 1.5 2.2 6.2 0.3 2.5 2.0 0.9 -0.2 0.5 -2.0
Wears glasses or contact lenses 0.9 1.1 5.1 -0.4 -0.4 -1.1 0.8 -0.1 2.3 0.5
Ever taken oral contraceptive pill 1.1 1.2 4.9 0.2 0.7 -0.1 0.9 2.2 -0.2 1.5
Hearing aid user 1.4 1.5 2.9 1.3 -0.5 1.4 0.3 1.7 1.4 1.3
Mother’s age at death 1.5 1.9 4.4 -0.6 -0.3 -1.3 -2.1 -1.8 1.1 -1.6
Financial situation satisfaction 1.2 1.5 4.7 -1.6 -1.1 -0.4 0.0 -2.2 -0.3 -1.4
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.0 -0.8 0.2 -0.7 0.9 -1.0 1.4 0.1
Commuting to job workplace: Public transport 1.1 1.4 3.5 1.3 1.9 0.8 1.1 0.9 0.1 -1.3
Eye problems/disorders: Glaucoma 1.2 1.4 3.8 0.6 1.7 0.2 1.1 1.3 0.0 -1.9
Medication: Blood pressure 1.7 3.2 11.6 2.2 0.6 1.2 3.4 1.0 -0.1 -1.8
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.0 -1.4 0.2 -0.4 -1.4 0.2 0.0 1.0
Supplements: Fish oil (including cod liver oil) 0.5 0.6 2.3 0.8 -0.1 -1.5 -1.2 -0.2 -0.0 0.3
High cholesterol (Self-reported) 0.2 0.4 1.0 -0.8 0.6 -1.0 0.5 -0.3 -0.5 0.7
Medication: Bendroflumethiazide 0.9 1.3 6.3 1.2 0.8 0.3 2.5 0.2 -0.6 -0.2
Medication: Paracetamol 0.6 1.0 3.6 -1.9 1.2 -0.3 0.6 -0.1 1.1 -0.2
Medication: Lisinopril 3.0 3.8 9.1 3.0 0.5 2.0 3.0 1.0 1.5 -1.2
Medication: Atorvastatin 0.6 0.8 2.0 -0.2 -0.4 1.2 1.4 -0.2 0.9 -1.1
Illnesses of father: High blood pressure 0.6 0.8 1.9 -0.5 0.0 -1.1 1.2 -1.0 1.4 -0.0
Alcohol drinker status: Never 0.5 0.6 1.2 -1.0 -1.0 -0.1 -1.1 -0.8 0.4 0.6
Ever smoked 0.6 1.0 2.6 1.2 0.4 1.5 0.1 -0.1 -1.6 -0.7
Basal metabolic rate 0.2 1.2 2.6 -1.6 -1.0 -0.4 -1.6 -1.2 -0.6 0.4
Leg fat percentage (left) 0.3 1.0 3.6 -0.4 -0.9 0.7 0.4 1.0 -0.8 1.9
Arm fat-free mass (left) 0.1 0.5 1.3 -1.0 -0.5 -0.3 -1.1 -0.9 -0.6 0.3
Number of operations (self-reported) 0.6 0.8 3.3 -1.3 -0.2 0.4 -1.8 -0.8 0.1 -0.2
Average weekly beer plus cider intake 0.5 0.8 1.8 0.0 -1.4 -0.9 -0.0 1.1 1.0 0.6
Irritability 1.1 1.9 7.0 0.1 0.1 1.3 -0.7 -1.9 -0.9 -2.7
Risk taking 0.5 0.7 3.1 -0.7 0.1 -0.7 -0.5 -1.8 0.1 -0.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.5 1.9 0.6 0.2 1.0 1.5 1.0 0.2
Fractured/broken bones in last 5 years 0.6 0.8 2.5 1.6 -0.1 -0.1 -0.5 0.3 -0.8 1.5
Age started oral contraceptive pill 0.1 0.2 0.5 0.4 0.7 0.1 -0.4 0.3 0.4 -0.1
Diastolic blood pressure, automated reading 0.9 2.8 13.0 -0.2 -0.8 -0.1 0.5 2.3 -0.6 3.6
Ever depressed for a whole week 2.1 2.6 11.5 -1.4 0.8 -0.7 -0.7 -3.4 -0.4 -1.6
Unable to work because of sickness or disability 3.3 4.3 15.2 -1.8 -2.3 -3.9 -1.3 -0.7 0.4 2.0
Commuting to job workplace: Cycle 2.4 2.9 7.0 -2.1 -1.4 -1.3 -2.6 -2.1 -0.5 0.5
Myopia 1.5 2.2 8.1 -0.5 -0.7 0.1 0.9 1.7 2.8 1.6
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.9 0.9 0.8 0.4 -1.7 1.6 0.1 -0.5
Cholesterol lowering medication 0.2 0.3 0.9 0.5 0.9 0.3 0.9 0.7 -0.3 0.0
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.3 0.5 -0.8 0.8 -1.1 -0.6 -0.7 0.0
Pain experienced in last month 1.2 2.0 6.5 2.6 0.6 2.0 0.8 0.9 0.5 -1.2
Supplements: Calcium 0.6 0.6 1.9 -0.7 -1.4 0.3 -1.3 0.3 0.4 -0.1
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 0.4 0.2 1.0 0.5 -0.9 -0.1 -0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.7 1.6 -0.9 -0.3 1.3 1.3 -0.5 0.1 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 3.6 -0.3 -0.3 -0.3 -1.3 1.1 0.1 1.9
Heart disease (siblings) 0.8 1.0 3.7 -1.3 -0.5 -0.3 -1.0 0.2 -0.5 1.9
Alcohol drinker status: Previous 0.2 0.2 0.6 -0.3 -0.5 0.4 0.3 -0.2 0.7 -0.3
Pack years of smoking 0.9 1.3 2.9 -0.6 -1.7 -1.2 -1.0 -0.7 -0.4 1.7
Impedance of whole body 0.6 3.1 9.8 2.2 0.2 3.1 1.4 1.8 1.2 -0.5
Leg fat mass (left) 0.3 1.2 2.8 -1.4 -1.4 -0.0 -0.7 -0.3 -0.9 1.7
Arm predicted mass (left) 0.1 0.7 1.6 -1.3 -0.7 -0.5 -1.2 -1.1 -0.5 0.3