Hub : Genes

RASSF8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1640	0.0470	0.00019	0.064	0.025	0.056	0.088	0.061	3.3e-08	0.00042	2.0e-07	8.0e-11	6.7e-08
2	GTEx	Cells Transformed fibroblasts	0.2320	0.0630	0.00006	0.133	NA	0.131	NA	0.124	3.7e-10	NA	5.1e-10	NA	1.6e-09
3	GTEx	Muscle Skeletal	0.1505	0.0445	0.00064	0.077	NA	0.060	NA	0.072	5.5e-08	NA	1.5e-06	NA	1.5e-07
4	GTEx	Skin Sun Exposed Lower leg	0.0990	0.0380	0.00440	0.012	NA	-0.001	NA	-0.001	3.1e-02	NA	4.2e-01	NA	4.0e-01
5	GTEx	Testis	0.3320	0.1030	0.00440	0.267	NA	0.229	NA	0.260	2.9e-12	NA	1.5e-10	NA	6.5e-12
6	ROSMAP	Brain Pre-frontal Cortex	0.0565	0.0226	0.00390	0.008	0.009	0.031	0.013	0.022	2.7e-02	0.02300	6.6e-05	6.8e-03	6.7e-04
7	TCGA	Colon Adenocarcinoma	0.0730	0.0380	0.00640	0.001	0.036	-0.001	NA	-0.001	2.8e-01	0.00360	4.0e-01	NA	3.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.2	5.0	0.7	-0.7	-2.2	0.2	-1.6	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	4.2	0.6	-1.2	-2.1	0.6	-0.2	0.5	-0.4
Depressed Affect (Nagel 2018)	0.6	1.2	4.1	1.4	-0.4	-1.1	2.0	0.8	-0.4	-0.4
Depression (Nagel 2018)	1.0	1.5	7.3	1.3	-0.5	0.3	2.7	0.9	-0.7	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.8	-1.2	0.6	-0.6	1.4	-0.4	0.2	0.8
Neuroticism (Nagel 2018)	0.7	1.6	5.3	0.5	-1.2	-1.9	2.3	0.4	-0.3	-0.7
Schizophrenia (2018)	0.3	0.5	1.2	0.2	-0.9	-0.8	0.5	1.1	0.8	-0.4
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	-0.6	0.9	1.0	0.9	0.5	0.7	0.7
Worry (Nagel 2018)	0.8	1.7	4.6	1.5	-1.5	-2.2	0.6	-0.7	1.2	-0.6
Alzheimer’s Disease (in mother)	1.1	1.2	3.2	-0.6	0.9	1.5	0.8	0.7	0.9	1.8
Alzheimer’s Disease (in father)	0.4	0.5	1.0	0.1	-0.6	-0.5	0.7	-0.4	-1.0	-0.9
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	-0.5	0.2	0.6	0.0	0.7	0.3	0.7
Crohns Disease (2017)	0.0	0.1	0.3	-0.5	0.2	-0.0	0.4	0.3	-0.5	-0.0
Irritable Bowel Disease (IBD)	0.3	0.8	3.5	1.1	-0.3	-1.9	0.7	0.5	-0.3	-0.5
Ulcerative Colitis (UC)	0.9	1.7	6.0	1.8	-0.4	-2.5	1.2	0.7	0.5	-0.7
Major Depression (MDD)	0.3	0.4	1.7	-0.1	0.3	-0.6	-0.5	1.3	-0.2	-0.2
Reaction Time	0.3	0.6	1.3	-0.5	1.1	0.1	1.1	-0.7	-1.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.8	-0.2	0.2	-0.8	-0.2	-1.3	0.4	1.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.3	0.4	1.8	-0.6	0.1	0.5	-0.3	0.4	-1.4	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.8	2.0	1.2	-0.1	-1.4	-0.2	-0.4	0.6	-1.3
Bipolar Disorder (2011)	2.4	2.3	5.5	0.8	-2.0	-2.1	-2.3	0.0	0.2	-1.2
Body Mass Index (BMI) (2010)	0.8	1.2	2.3	-1.1	0.7	1.5	0.8	1.1	-0.1	1.5
Coronary Artery Disease (CAD)	0.8	0.9	2.3	0.3	-1.0	-1.5	1.2	-1.3	-0.5	-0.2
Crohns Disease (2012)	0.2	0.3	1.2	-0.6	-0.3	-0.4	-0.3	0.2	-1.1	0.7
Mean Putamen Volume	0.8	0.9	1.9	-0.8	1.4	0.6	1.2	0.3	-1.2	0.9
Fasting Glucose	0.7	0.9	3.9	-0.8	-0.5	0.2	-2.0	-0.4	0.6	-1.0
HbA1C	0.3	0.4	0.9	-0.4	-0.5	0.9	0.7	-0.3	-0.0	0.9
HDL Cholesterol	0.1	0.1	0.4	-0.6	-0.4	0.3	0.0	-0.3	0.2	0.2
LDL Cholesterol	0.7	1.1	3.9	0.2	-2.0	0.2	-1.8	-0.5	0.3	-0.1
Lupus	0.5	0.7	3.8	0.5	-0.5	-0.4	0.7	-0.4	0.0	-2.0
Neuroticism (2016)	1.1	1.5	3.4	0.2	-1.8	-1.8	-0.0	-0.8	-0.7	-1.7
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.3	0.5	0.6	-0.2	-0.5	0.8	-0.6
Rheumatoid Arthritis	0.6	0.9	2.3	-0.3	-1.2	-0.9	1.5	0.2	1.2	0.1
Schizophrenia (2014)	0.2	0.5	1.5	-0.1	0.3	-0.5	1.2	0.4	1.2	-0.0
Triglycerides	0.3	0.5	1.2	-0.3	0.0	-0.6	1.0	-1.1	-0.0	-1.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	7.2	0.2	1.2	-0.2	2.7	0.6	-0.3	-0.2
Ulcerative Colitis	0.6	0.8	2.9	0.9	-0.8	-1.7	0.4	1.1	0.2	0.2
Blood Eosinophil Count	0.5	4.2	11.5	0.5	0.7	1.2	2.0	3.4	-0.0	3.4
Blood Platelet Count	0.1	1.1	4.0	-2.0	0.1	-0.1	-1.2	1.2	-0.4	0.8
Blood Red Count	0.1	0.7	1.3	-1.1	0.1	0.0	1.1	0.7	-1.1	1.1
Blood White Count	0.1	0.7	3.2	0.2	0.7	0.1	0.3	1.8	-0.9	0.5
Heel T-Score	1.3	10.3	39.2	-3.4	0.7	-3.0	0.1	0.1	-6.3	-3.5
BMI	0.2	1.4	4.1	1.4	2.0	0.2	1.9	-0.2	-0.7	-0.3
Height	0.6	11.9	22.1	3.7	-4.3	-4.7	-1.2	-2.5	-0.8	-4.6
Waist Hip Ratio (WHR)	0.4	1.8	7.0	0.5	-0.9	0.6	-0.8	1.5	-2.6	1.1
Systolic Blood Pressure	0.6	3.0	5.5	-2.0	2.4	1.7	1.4	0.4	-1.8	-1.7
Smoking Status	0.4	0.9	3.4	-0.2	0.7	-0.4	0.2	-0.1	1.9	1.5
Allergy or Eczema	0.1	0.2	0.5	-0.7	-0.3	-0.0	-0.0	0.2	0.7	0.7
Cardiovascular Disease	0.4	1.2	3.5	-0.2	-0.2	0.5	1.8	0.9	-1.9	-0.8
Hypothyroidism (self reported)	1.4	3.2	12.9	0.5	1.9	0.6	3.6	2.1	-0.2	0.9
Respiratory disease	0.4	0.9	3.3	0.5	-0.9	-1.8	0.2	0.4	-0.2	1.3
Type 2 Diabetes (T2D) (2018)	0.8	1.5	7.3	1.4	0.2	-0.4	0.5	-1.0	-2.7	-0.2
Lung FEV1/FVC ratio	0.3	1.6	4.1	-0.4	-2.0	-1.4	1.1	-0.5	0.9	-1.6
Lung FVC	0.3	1.3	3.5	0.8	0.2	1.9	-0.5	-0.6	1.7	1.3
Neuroticism	0.8	1.9	3.5	1.5	-1.2	-1.9	1.8	0.5	1.2	1.1
Chronotype (morning person)	0.2	0.4	1.9	-0.4	0.3	0.4	1.4	0.2	-0.5	-0.0
Hair Pigment	0.1	1.9	4.2	-1.0	0.2	2.0	1.8	1.3	-1.5	-0.9
Tanning	0.0	0.5	1.1	0.5	-0.9	0.7	-1.1	0.2	-0.3	0.6
Hand grip strength (left)	0.4	1.1	2.9	-0.3	-0.5	-0.9	-0.9	-0.9	-1.4	-1.7
Number of treatments/medications taken	0.4	0.8	2.6	1.5	0.5	-0.0	1.6	-0.3	-0.3	-0.2
Average weekly spirits intake	0.3	0.3	0.7	0.8	-0.4	-0.8	-0.8	0.4	-0.2	0.0
Sensitivity / hurt feelings	0.7	1.1	3.7	-1.0	-0.6	0.4	1.9	1.3	-0.8	-0.5
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.2	-0.2	0.4	1.6	2.1	1.1	-0.9	0.1
Hearing difficulty/problems: Yes	0.8	1.2	5.6	-0.6	0.2	-0.8	0.6	1.0	2.4	0.7
Relative age of first facial hair	0.5	1.1	5.3	-2.3	-1.1	0.2	-0.3	0.0	0.2	-1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.6	-0.5	-0.6	-0.1	1.6	-1.3	-0.8	-0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.6	0.2	-1.6	-1.0	-1.4	0.4	0.3	-0.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.3	-0.5	-1.5	-1.3	-0.1	0.7	0.9	-0.2
Systolic blood pressure, automated reading	0.4	1.3	2.8	-0.6	1.7	0.7	1.4	-1.3	-0.5	-1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.6	0.5	0.0	-1.0	0.5	-0.2	-0.4	-1.2
Angina	0.5	0.7	1.3	1.1	1.1	-0.3	0.6	0.3	1.0	0.9
Medication for hormone replacement therapy	0.5	0.5	1.0	0.6	-0.8	-0.5	-1.0	0.4	0.6	-0.9
Vitamin and mineral supplements	0.6	0.8	3.8	0.5	-0.2	-0.3	1.9	1.1	-0.1	-0.5
Supplements: Zinc	0.9	1.0	1.5	-1.1	0.6	-0.4	-1.2	-1.2	1.2	-0.9
Medication: Co-codamol	0.4	0.5	0.8	-0.6	-0.8	0.9	-0.1	0.8	0.8	0.1
Medication: Metformin	0.8	1.2	3.4	0.9	1.9	0.7	0.0	-0.3	-1.8	-0.5
Diabetes (father)	0.3	0.3	1.3	-0.7	-1.2	0.4	0.2	-0.1	0.1	0.6
Diabetes (mother)	0.7	0.8	4.7	-0.3	0.4	0.8	0.2	0.1	-2.2	0.5
Severe depression (siblings)	0.7	0.8	2.3	0.1	0.8	1.2	-0.6	1.5	-0.8	-0.1
Pack years adult smoking proportion	0.5	0.8	1.8	0.3	1.3	0.9	1.3	0.7	-0.6	0.4
Impedance of leg (right)	0.1	0.5	1.7	-0.6	0.2	-0.0	1.3	0.4	-0.5	0.9
Leg fat-free mass (left)	0.3	1.4	5.8	1.4	-0.9	-0.7	-0.5	-0.2	-0.7	-2.4
Trunk fat percentage	0.4	1.5	4.8	0.9	0.5	0.2	2.2	2.2	-0.3	-0.1
Hand grip strength (right)	0.5	1.5	2.6	-0.4	-1.2	-1.3	-1.6	-1.2	-1.3	-1.1
Townsend deprivation index at recruitment	1.0	1.4	4.2	-1.0	1.2	2.0	0.8	1.1	0.7	0.8
Current tobacco smoking	0.4	0.6	2.5	0.1	-0.6	-0.8	-0.6	-1.6	-0.6	-0.5
Average weekly fortified wine intake	0.6	0.7	2.2	-0.1	0.2	0.4	0.6	1.5	-1.2	0.8
Maternal smoking around birth	0.1	0.2	0.5	-0.1	-0.4	0.2	0.2	-0.5	0.3	0.7
Fed-up feelings	0.2	0.4	0.9	0.9	0.2	-0.2	1.0	0.8	0.3	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.8	0.7	-0.7	-0.0	2.2	1.4	-0.5	1.0
Relative age voice broke	0.7	1.1	2.6	-1.3	-0.5	1.1	1.6	-0.2	1.0	-0.7
Taking other prescription medications	0.5	0.8	4.3	2.1	0.5	0.3	0.7	0.0	-0.2	0.9
Age when periods started (menarche)	0.3	0.7	1.6	0.8	-0.8	-1.3	-0.6	0.0	-1.0	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	-0.8	0.2	-0.8	-0.6	-0.2	-0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	21.1	-0.6	-0.0	-1.2	0.3	-0.8	-4.6	-1.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	4.5	-0.1	1.6	2.1	0.2	0.8	0.2	1.3
Qualifications: CSEs or equivalent	1.8	2.3	4.7	1.1	1.1	1.7	-1.8	-2.2	0.0	-1.8
Serious illness, injury or assault to yourself	1.5	1.8	4.2	-0.1	-1.2	0.4	-2.0	-2.1	1.5	-0.6
High blood pressure	0.6	1.6	4.1	0.4	-0.1	1.6	1.4	2.0	-0.8	-1.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	-0.6	0.1	0.4	-0.4	0.9	0.0	1.1
Multivitamins +/- minerals	0.4	0.5	2.5	0.2	-0.2	-0.0	-0.9	-0.1	-0.6	1.6
Stomach or abdominal pain in last month	0.9	1.2	3.1	1.1	1.8	0.7	0.7	0.1	0.6	1.6
Supplements: Glucosamine	0.3	0.3	1.9	-0.4	0.4	-1.4	0.1	-0.2	0.1	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.7	1.9	0.7	0.3	-0.5	1.2	0.5	1.2
Medication: Atenolol	0.3	0.4	1.3	0.7	0.9	-0.3	-1.1	-0.1	0.2	0.1
Medication: Levothyroxine sodium	2.8	4.8	15.1	-0.1	3.1	1.4	3.9	2.4	0.4	0.8
Sitting height	0.7	5.0	9.6	1.2	-2.7	-2.2	-0.8	-2.1	-2.7	-3.1
Chronic bronchitis/emphysema (father)	2.1	2.4	6.2	0.3	-0.1	2.3	0.2	2.5	1.8	1.5
High blood pressure (mother)	0.5	0.6	2.3	-0.2	1.5	0.4	-0.6	1.1	-0.2	-0.6
Body mass index (BMI)	0.2	0.9	3.5	0.9	0.8	0.8	1.9	0.3	-0.5	-0.2
Impedance of leg (left)	0.2	0.9	2.8	-0.7	0.4	0.5	1.0	1.2	-0.5	1.7
Leg predicted mass (left)	0.3	1.5	5.9	1.6	-1.1	-0.8	-0.4	-0.1	-0.7	-2.4
Trunk fat mass	0.3	1.3	3.1	1.4	-0.2	-0.3	1.8	1.3	-0.9	-1.1
Waist circumference	0.3	1.2	3.3	1.4	-0.8	0.5	0.9	0.5	-1.8	-1.1
Number of incorrect matches in round	0.3	0.6	1.6	1.2	-0.8	-1.3	-0.2	0.2	-0.1	-0.2
Past tobacco smoking	1.3	2.4	5.9	0.6	-0.3	-1.7	-0.1	-2.1	-1.8	-2.4
Alcohol usually taken with meals	0.7	1.1	3.3	0.5	-1.4	0.6	0.4	-0.7	-1.8	-1.1
Nervous feelings	0.3	0.6	1.3	0.6	-0.7	-0.6	-0.9	0.7	1.1	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.8	0.1	-0.7	-0.5	1.0	1.4	-0.1	-0.4
Hearing difficulty/problems with background noise	0.8	1.3	6.2	-0.1	-0.7	0.3	0.3	0.5	2.5	1.4
Hair/balding pattern: Pattern 2	1.2	1.5	4.1	0.3	1.1	1.7	1.4	2.0	-0.1	-0.4
Had menopause	0.5	0.6	1.6	-0.7	-1.0	-0.4	0.2	1.0	0.2	-1.3
Had other major operations	0.4	0.5	2.2	0.4	-0.4	-0.5	0.6	0.6	-0.0	-1.5
Forced vital capacity (FVC)	0.1	0.5	1.1	0.8	0.2	-1.1	-0.6	-1.0	-0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	33.9	-0.7	-0.2	-2.1	-0.2	-0.5	-5.8	-3.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	0.8	-0.1	-0.6	0.9	0.6	0.2	0.8
Qualifications: None of the above	0.8	1.7	8.6	0.7	2.9	-0.1	0.8	0.3	1.2	-0.6
Financial difficulties in last 2 years	1.7	2.3	12.7	0.1	1.4	3.6	1.1	0.4	-0.6	-0.1
Mouth/teeth dental problems	0.7	1.1	4.1	-0.0	-0.0	1.0	2.0	0.5	1.5	-0.3
Heart attack	0.7	0.9	3.9	2.0	-0.7	0.8	-1.0	0.1	0.7	-0.0
Allergy	0.4	0.9	3.9	-0.6	0.5	-0.1	0.1	-1.1	-0.4	-2.0
Pain all over the body in last month	1.3	1.4	3.8	1.3	0.6	0.8	1.9	0.6	1.2	1.2
Diabetes (self-reported)	1.2	1.9	7.4	0.5	0.0	-0.5	-1.3	-1.5	-2.7	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.3	-0.0	0.8	-0.3	-1.8	-0.1	0.2	0.9
Medication: Ramipril	2.2	2.8	6.1	0.1	-1.3	-0.4	-1.7	-2.0	-2.2	-2.5
Medication: Simvastatin	0.3	0.5	1.3	0.2	-0.5	-1.1	-0.7	-0.5	-1.1	-0.4
Fluid intelligence score	0.2	0.4	1.2	-1.1	0.2	0.3	-0.3	-1.0	-0.1	0.7
Illnesses of siblings	0.5	0.7	1.8	-0.0	-1.3	-0.9	0.5	-0.6	0.8	0.9
Neuroticism score	0.4	0.8	2.6	0.4	-1.1	-0.8	1.6	0.5	0.4	0.9
Weight	0.3	1.4	4.0	1.6	-0.9	-0.6	1.0	-0.2	-1.1	-2.0
Impedance of arm (right)	0.1	0.6	2.9	0.1	-0.3	-0.6	0.3	1.7	0.7	0.5
Arm fat percentage (right)	0.3	1.4	5.3	1.0	0.5	0.5	2.3	1.6	-0.2	0.2
Trunk fat-free mass	0.8	4.4	10.0	1.8	-2.2	-1.7	-0.9	-2.5	-1.6	-3.2
Hip circumference	0.4	1.5	5.3	1.0	-0.5	-0.4	1.8	-0.8	-0.6	-2.3
Time employed in main current job	1.5	1.7	4.2	-1.7	-0.4	-1.5	0.8	1.2	-2.1	0.1
Alcohol intake versus 10 years previously	1.6	2.4	9.1	0.8	2.1	-0.1	-1.3	-3.0	0.5	-0.9
Father’s age at death	1.4	1.9	5.6	0.6	1.2	2.4	-2.0	0.9	0.8	0.8
Worrier / anxious feelings	0.4	0.7	1.9	1.4	-0.4	0.9	1.0	0.3	1.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.7	0.6	1.6	0.5	1.4	-0.1	-0.0	0.0
Falls in the last year	0.5	0.7	1.8	-1.3	0.9	1.2	0.2	-0.7	0.3	0.3
Hair/balding pattern: Pattern 3	0.6	0.9	2.4	-0.4	0.5	0.6	-1.2	0.1	1.4	1.5
Number of live births	0.5	0.7	2.7	1.0	-0.1	1.6	-0.4	0.0	-0.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.3	0.4	-0.3	-0.6	-0.4	-1.1	0.2	-0.9
Pulse rate	1.0	1.7	7.0	2.6	-0.5	-1.5	0.3	-0.1	1.5	0.2
Happiness	1.3	1.5	4.6	2.2	0.2	-0.1	0.7	-0.6	1.9	1.3
Noisy workplace	0.5	0.6	1.9	-0.3	-0.1	0.0	0.8	1.2	0.1	1.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	0.0	-0.2	0.5	0.0	-0.7	-0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	-0.0	0.2	-0.7	-0.9	-0.1	0.2	-1.4
Mouth/teeth dental problems: Dentures	1.0	1.7	4.6	0.7	-0.7	-2.2	-1.8	-1.4	-0.7	-0.5
Asthma	0.9	1.8	5.5	0.4	-0.4	-0.0	1.3	2.1	-0.7	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.5	-0.3	-0.5	0.4	1.6	0.5	-0.6	0.4
Medication: Cholesterol lowering	0.2	0.3	1.1	1.0	0.2	0.1	-0.2	-0.4	-1.1	-0.1
Depression (self-reported)	1.2	1.5	5.7	-0.7	0.2	0.0	0.7	2.4	-1.9	0.4
Medication: Lansoprazole	0.4	0.4	1.2	1.1	-0.0	-1.0	-0.2	0.8	0.2	-0.2
Prospective memory result	1.1	1.3	5.6	-1.2	-0.8	-0.9	0.4	0.1	-0.7	-2.4
Lung cancer (father)	1.4	1.6	4.7	1.7	-0.4	-2.2	0.6	0.4	1.7	-0.3
Illnesses of mother	0.2	0.2	0.5	-0.2	0.5	0.4	-0.5	-0.0	0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.7	0.4	0.1	-0.4	-0.1	-1.3	0.5	-1.2
Pulse wave Arterial Stiffness index	1.1	1.3	5.5	1.2	-0.1	-0.2	2.4	-1.2	0.9	0.2
Impedance of arm (left)	0.3	1.2	6.9	0.0	0.1	-0.8	0.4	2.6	0.6	0.5
Arm fat mass (right)	0.3	1.1	3.8	1.6	0.2	-0.1	1.9	0.6	-0.7	-0.7
Trunk predicted mass	0.8	4.4	9.9	1.8	-2.2	-1.7	-0.9	-2.5	-1.6	-3.1
Standing height	0.8	8.1	17.1	2.0	-3.8	-3.7	-1.6	-1.6	-1.6	-4.1
Length of working week for main job	0.7	0.8	3.5	0.2	1.9	0.5	-0.1	0.5	0.9	0.8
Exposure to tobacco smoke at home	0.7	0.8	3.1	0.2	0.9	1.1	0.3	-0.4	0.1	1.8
Breastfed as a baby	0.6	0.8	2.8	-0.5	-1.7	-0.6	-1.1	-0.7	0.2	-0.3
Tense / ‘highly strung’	0.4	0.6	2.1	0.8	0.3	-0.1	1.1	0.2	1.5	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	8.5	0.1	1.5	0.0	0.9	2.9	-0.2	1.2
Hair/balding pattern: Pattern 4	0.8	2.0	4.6	-2.1	-0.7	-2.1	0.8	-1.4	-1.3	-0.1
Birth weight of first child	0.3	0.5	1.3	-1.1	-1.2	0.0	0.3	0.9	-0.5	0.1
Peak expiratory flow (PEF)	0.2	0.5	2.8	1.7	0.0	0.4	0.2	-0.3	0.5	-0.1
Pulse wave reflection index	0.6	0.8	4.0	-0.6	0.6	0.4	2.0	-0.7	0.2	0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.8	-0.2	-0.9	-0.4	-0.1	1.1	0.8	1.9
Loud music exposure frequency	0.8	0.9	2.0	0.7	0.2	1.4	0.7	-0.3	1.3	1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.1	-0.4	-2.3	1.0	-1.1	-0.8	-1.8	-0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.7	0.3	-0.0	-0.1	2.2	0.9	-1.0	0.8
Blood clot in the leg (DVT)	1.5	1.9	8.0	1.8	0.2	0.5	-0.1	-1.2	2.8	0.5
Medication: Paracetamol	1.0	1.7	5.3	0.6	1.6	-0.1	2.3	1.8	-0.4	0.3
Headache pain in last month	0.2	0.3	1.3	0.2	-0.4	0.1	1.2	0.4	0.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.1	-1.2	-0.3	-0.1	-1.1	0.3	1.0	1.5
Glaucoma (self-reported)	1.5	1.7	7.7	-0.9	-2.8	0.1	-1.0	0.8	-0.3	1.3
Gout (self-reported)	0.5	0.7	2.0	0.4	0.4	0.7	-1.1	0.8	-0.6	1.4
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	11.3	0.7	2.5	1.4	3.4	1.6	0.2	1.1
Medication: Amlodipine	2.1	2.9	8.4	-1.3	2.2	2.9	-0.8	1.8	0.7	0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	0.8	0.2	-0.7	0.6	-0.4	0.3	-0.5
Birth weight	0.3	0.7	1.0	0.9	-0.9	-0.3	-1.0	0.4	0.9	-0.9
Chronic bronchitis/emphysema (mother)	1.9	2.3	9.1	1.0	-3.0	-2.1	-0.3	-0.1	-0.1	-1.0
High blood pressure (siblings)	0.7	1.1	2.4	-0.7	1.5	1.5	-1.1	0.9	-0.2	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.7	1.9	0.9	0.1	-0.9	-0.3	-1.4	0.3	-1.1
Body fat percentage	0.4	1.5	5.7	0.8	0.5	0.5	2.4	1.9	-0.3	-0.1
Leg fat percentage (right)	0.3	1.2	6.6	0.6	0.2	0.7	2.6	0.8	-0.3	-0.2
Arm fat-free mass (right)	0.4	2.2	6.7	1.3	-1.1	-0.9	-0.4	-1.3	-1.7	-2.6
Exposure to tobacco smoke outside home	1.0	1.3	4.1	0.7	-1.0	-0.0	-1.1	1.7	0.2	2.0
Comparative body size at age 10	0.2	0.5	1.0	0.8	-0.8	0.4	-0.2	0.3	0.9	1.0
Number of full brothers	0.5	0.7	2.2	0.3	1.5	1.2	0.1	-0.7	-0.2	-0.5
Worry too long after embarrassment	0.3	0.5	1.8	-0.2	0.1	0.5	1.3	-0.5	0.2	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	6.0	0.2	1.1	0.4	0.2	2.4	0.1	0.7
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	1.0	-0.1	-1.1	0.7	0.6	0.2	0.6
Number of children fathered	0.3	0.3	1.6	0.5	0.2	-0.0	0.3	-1.2	-0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	1.2	-1.0	0.5	-0.2	1.0	0.5	1.3
Age at first live birth	0.3	0.6	2.0	0.2	1.4	-0.1	1.1	0.7	-0.7	0.2
Pulse wave peak to peak time	1.2	1.5	6.3	-1.0	-0.3	-0.0	-2.5	1.1	-1.1	-0.6
Health satisfaction	0.7	0.9	2.4	1.5	-0.7	0.7	0.7	0.3	1.5	-0.2
Shortness of breath walking on level ground	0.7	0.8	1.8	-0.5	0.6	0.8	1.0	1.0	0.8	1.4
Qualifications: College or University degree	0.5	1.5	5.0	-0.1	0.8	-0.6	1.2	-1.4	1.0	2.2
Eye problems/disorders: None of the above	1.3	1.5	6.3	0.5	0.7	0.7	-0.9	-1.3	2.5	-0.5
Mouth/teeth dental problems: Loose teeth	3.0	3.5	8.8	-2.9	0.7	3.0	-0.6	0.2	-2.5	0.3
Emphysema/chronic bronchitis	0.7	0.8	2.4	-0.0	0.2	-0.8	0.6	1.4	-0.6	1.5
Medication for pain relief, constipation, heartburn	1.3	2.2	9.2	-1.3	-1.3	0.3	-3.0	-1.2	0.7	-0.9
Neck or shoulder pain in last month	1.2	1.7	3.5	0.8	0.8	0.8	1.9	1.8	-0.1	1.8
Medication: Blood pressure	0.9	1.7	5.1	0.3	0.7	0.2	1.1	0.4	-2.3	-2.1
Angina (self-reported)	0.5	0.7	1.6	0.9	1.3	-0.3	0.8	0.5	0.8	0.7
Migraine (self-reported)	0.1	0.2	0.5	0.4	-0.2	0.2	0.6	0.1	-0.2	0.7
Medication: Ibuprofen	0.6	0.7	2.2	-0.4	-0.7	0.6	1.5	0.5	-1.3	-0.3
Medication: Allopurinol	0.2	0.3	1.3	0.4	0.7	0.2	-0.0	0.2	-0.1	1.1
Medication: Omeprazole	0.2	0.2	0.5	-0.4	-0.5	-0.0	-0.7	0.1	-0.1	-0.6
Medication: Seretide 50 evohaler	0.5	0.5	1.7	0.6	-0.4	0.2	1.3	-1.0	0.4	-0.5
Mean time to correctly identify matches	0.1	0.2	0.7	-0.1	-0.2	-0.9	0.7	0.1	-0.6	-0.3
Heart disease (mother)	1.7	2.1	9.2	-0.5	-0.7	-2.0	0.6	-0.5	0.5	-3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	0.3	1.1	0.4	1.1	-1.3	-0.1	-0.0
Whole body fat mass	0.2	1.0	2.6	1.3	0.2	-0.0	1.6	1.2	-0.9	-0.7
Leg fat mass (right)	0.3	1.2	4.9	1.2	0.1	0.1	2.2	0.8	-0.8	-1.0
Arm predicted mass (right)	0.4	2.1	5.1	1.3	-1.0	-1.1	-0.4	-1.3	-1.9	-2.3
Pulse rate, automated reading	1.3	4.3	11.0	3.3	-1.5	-3.2	-1.0	-1.1	1.3	-1.6
Alcohol intake frequency.	0.4	1.0	2.1	-1.4	0.2	0.8	-1.4	-0.2	-1.1	-0.9
Comparative height size at age 10	0.7	4.1	10.7	0.9	-2.2	-2.8	-0.9	-1.7	-0.8	-3.3
Number of full sisters	1.7	2.1	6.5	0.7	1.6	-0.2	2.5	-0.9	1.6	-1.3
Suffer from ‘nerves’	0.8	1.2	4.0	0.3	-1.9	-2.0	0.4	0.3	0.3	-0.4
Overall health rating	0.4	1.0	4.8	2.2	-0.8	-0.6	0.7	-0.3	0.6	0.0
Chest pain or discomfort	0.6	0.9	4.0	-0.1	0.8	0.1	-2.0	1.0	-0.6	0.5
Had major operations	0.5	0.6	2.2	1.5	-0.9	-0.1	-0.9	0.3	-0.3	0.5
Age at last live birth	0.6	0.9	2.9	0.6	1.2	0.7	1.7	-0.2	-1.0	-0.5
Family relationship satisfaction	0.4	0.5	1.1	0.6	1.0	-0.9	0.7	-0.4	0.2	0.5
Leg pain on walking	1.3	1.6	4.5	1.1	0.3	0.9	1.3	2.1	0.8	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.2	1.6	-1.1	1.0	-1.8	1.6	0.7	-1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	-0.2	-0.4	-0.3	-0.5	-0.4	0.6	-1.0
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	8.7	0.2	-3.0	-2.3	0.5	-1.0	-0.7	-0.7
Medication: Aspirin	0.6	0.8	4.0	2.0	-0.0	0.5	0.7	0.0	-0.7	-0.5
Supplements: Vitamin C	1.5	1.7	4.7	-1.1	2.2	1.5	-1.2	-1.0	1.1	-0.5
Knee pain experienced in last month	1.1	1.7	5.9	-2.4	-1.1	-0.5	1.1	0.1	-1.8	-0.6
Hypertension (Self-reported)	0.7	2.0	4.2	0.1	0.2	2.0	1.2	2.0	-1.6	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.7	0.4	-1.2	-0.1	-1.3	1.3	-0.4	1.0
Illnesses of father: Heart disease	0.2	0.3	0.7	0.8	-0.7	-0.6	-0.4	-0.0	0.3	-0.0
Illnesses of siblings: Diabetes	1.3	1.6	3.4	0.7	0.8	1.0	1.8	1.8	-1.2	0.8
Smoking status: Previous	2.1	3.1	6.6	-0.5	0.7	2.1	0.4	2.6	1.9	2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.4	0.8	-1.8	-1.8	0.4	0.2	-1.1	-1.2
Whole body fat-free mass	0.5	2.9	8.2	1.7	-1.8	-1.1	-0.9	-1.6	-1.2	-2.9
Leg fat-free mass (right)	0.3	1.4	4.9	1.4	-1.1	-0.7	-0.9	-0.0	-0.7	-2.2
Arm fat percentage (left)	0.5	1.8	6.7	1.0	0.8	0.5	2.6	2.0	-0.3	0.2
Average weekly red wine intake	1.4	2.1	6.5	1.4	-1.6	-1.0	0.2	-0.7	-1.4	-2.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.7	0.1	-0.3	0.8	0.2	0.1	0.3
Mood swings	0.3	0.5	1.7	-0.1	-1.3	-1.2	0.2	0.3	0.2	0.2
Loneliness, isolation	0.4	0.5	1.4	0.9	0.6	0.9	1.2	0.0	-0.2	-0.1
Long-standing illness, disability or infirmity	0.7	1.1	2.3	0.3	1.2	1.0	0.9	0.5	-1.3	1.5
Ever had bowel cancer screening	1.1	1.3	2.9	1.7	-1.3	-0.7	-1.3	1.5	0.4	-0.4
Diabetes diagnosed by doctor	1.4	2.3	9.9	-0.2	0.5	-0.6	-1.4	-1.7	-3.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	-0.7	0.4	-0.0	0.8	1.1	-0.5	0.3
Friendships satisfaction	0.6	0.7	1.2	0.9	0.1	-0.9	-1.1	-1.1	0.7	-0.7
Qualifications: nursing, teaching	0.6	0.9	2.6	-0.5	-1.6	-0.2	0.1	0.4	-1.5	-1.0
Commuting to job workplace: Walk	0.2	0.2	0.6	0.5	-0.4	0.4	0.2	-0.8	0.5	0.1
Eye problems/disorders: Cataract	0.4	0.5	1.3	0.3	-0.2	-0.5	0.7	0.9	-0.7	1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.9	-1.2	-0.6	0.1	-1.4	0.5	-1.6	1.7
Medication for cholesterol	0.3	0.5	1.8	-0.5	0.6	0.6	0.6	-0.2	0.2	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	6.2	-0.2	1.3	0.6	1.0	2.5	1.6	0.6
Back pain experienced in last month	1.1	1.6	4.8	2.2	-1.3	0.6	-1.0	0.5	1.8	-0.2
Mineral and other dietary supplements	0.4	0.5	1.2	-0.7	-0.4	0.7	0.6	0.9	-0.0	-1.1
Breast cancer (self-reported)	0.6	0.7	2.7	-0.6	0.1	-0.2	-0.4	-1.6	-1.4	0.1
Asthma (self-reported)	0.8	1.7	5.2	0.7	-0.3	-0.4	1.3	1.9	-0.7	2.3
Osteoporosis (self-reported)	0.6	0.8	1.7	1.0	0.0	-1.3	-0.2	0.3	1.0	-1.2
Osteoarthritis (self-reported)	0.5	0.6	2.3	-0.7	-0.5	1.5	-0.6	0.5	-0.4	0.6
Medication: Aspirin	0.9	1.2	4.1	2.0	-0.4	0.4	1.0	-0.0	-1.2	-1.1
Medication: Gliclazide	1.0	1.1	2.2	1.5	0.9	-0.7	-1.0	-0.7	-1.5	0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	1.6	-0.5	0.4	-1.3	0.4	-0.4	-0.1	-0.2
Smoking status: Current	0.4	0.6	2.1	0.0	-0.5	-0.8	-0.2	-1.5	-0.9	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	0.2	0.1	0.5	0.5	-0.5	0.1	-0.0
Whole body water mass	0.5	2.8	7.7	1.6	-1.8	-1.1	-0.7	-1.6	-1.3	-2.8
Leg predicted mass (right)	0.2	1.3	4.7	1.3	-1.1	-0.6	-0.8	0.0	-0.8	-2.2
Arm fat mass (left)	0.3	1.1	3.6	1.6	0.1	-0.1	1.9	0.7	-1.0	-0.7
Number of self-reported non-cancer illnesses	0.8	1.3	3.8	0.4	-1.0	1.0	0.7	1.0	-1.9	1.3
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.8	-0.6	0.5	0.8	0.7	0.8	-0.1
Miserableness	0.5	0.8	2.5	0.5	-0.0	0.4	1.6	1.2	-1.1	-0.0
Guilty feelings	1.0	1.5	2.6	-1.4	0.7	0.7	1.1	1.6	-1.1	1.5
Wears glasses or contact lenses	0.9	1.1	3.4	-0.8	1.8	0.3	0.7	0.7	-1.5	0.4
Ever taken oral contraceptive pill	0.3	0.4	2.0	-0.1	-0.2	1.4	-0.1	0.1	0.3	0.7
Hearing aid user	2.4	2.7	13.8	0.0	1.0	-3.7	2.0	-0.2	-0.2	0.5
Mother’s age at death	1.1	1.3	2.5	0.5	-0.7	1.2	1.6	1.1	1.0	1.6
Financial situation satisfaction	0.7	0.9	3.6	1.9	-1.1	0.3	0.2	-0.5	-0.7	-0.8
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	1.3	-1.4	-1.1	-0.6	-0.7	-0.1	0.4
Commuting to job workplace: Public transport	0.9	1.1	2.7	0.1	-0.8	-0.7	1.6	0.8	-1.3	1.2
Eye problems/disorders: Glaucoma	1.4	1.7	6.1	-1.2	-2.5	-0.8	-1.2	0.6	-0.9	1.0
Medication: Blood pressure	0.5	0.9	3.0	-0.1	0.8	0.9	0.7	1.7	0.7	-1.0
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.7	1.0	-1.2	-1.9	-0.8	-0.9	0.8	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	3.2	0.4	0.8	-0.5	0.1	-0.3	-0.5	1.8
High cholesterol (Self-reported)	0.2	0.3	1.6	1.2	-0.2	-0.2	0.2	-0.4	-0.1	0.7
Medication: Bendroflumethiazide	0.7	1.1	3.8	1.2	-1.0	-0.8	0.4	2.0	-0.4	-0.8
Medication: Paracetamol	1.0	1.5	7.2	1.0	1.2	-0.5	2.7	0.6	0.0	-0.5
Medication: Lisinopril	0.4	0.5	1.8	0.2	1.0	0.3	-0.1	0.9	-1.3	-0.1
Medication: Atorvastatin	1.5	1.8	5.6	1.9	-1.1	1.3	0.4	-2.4	0.7	-0.2
Illnesses of father: High blood pressure	0.3	0.3	0.8	0.9	0.1	0.8	-0.0	0.2	0.8	-0.5
Alcohol drinker status: Never	0.5	0.6	1.1	0.3	-0.7	-1.1	-0.0	0.5	1.0	-1.0
Ever smoked	0.9	1.6	2.3	-1.2	-0.6	1.4	-1.2	1.4	1.5	1.4
Basal metabolic rate	0.4	2.1	6.2	1.6	-1.5	-0.9	-0.4	-1.1	-1.3	-2.5
Leg fat percentage (left)	0.3	1.1	5.4	0.5	0.3	0.9	2.3	1.1	-0.3	0.1
Arm fat-free mass (left)	0.5	2.8	7.3	1.4	-1.6	-0.9	-0.2	-1.9	-1.8	-2.7
Number of operations (self-reported)	0.8	1.1	2.4	1.6	-0.9	-0.7	-1.4	-0.8	-0.6	-1.1
Average weekly beer plus cider intake	0.4	0.6	2.0	0.3	1.0	0.3	0.5	-1.4	0.3	-0.6
Irritability	0.6	1.1	3.1	0.5	-0.5	-0.8	1.4	-0.1	1.2	1.7
Risk taking	0.3	0.5	1.2	-0.6	-0.4	0.4	-1.1	0.3	0.8	-0.7
Ever had prostate specific antigen (PSA) test	1.5	1.7	6.6	2.6	-1.1	0.3	0.7	0.6	1.6	-0.8
Fractured/broken bones in last 5 years	0.9	1.1	3.4	0.1	-1.3	1.3	0.9	1.8	0.5	0.2
Age started oral contraceptive pill	0.8	1.0	2.9	1.7	-1.2	-1.0	0.9	-0.2	0.8	-0.2
Diastolic blood pressure, automated reading	0.4	1.3	5.4	-0.2	1.2	2.3	1.0	0.3	1.0	-0.1
Ever depressed for a whole week	0.5	0.6	1.5	0.0	-1.0	-1.1	-1.2	-0.2	-0.1	0.5
Unable to work because of sickness or disability	0.8	1.0	2.5	-1.0	-0.9	-0.8	-1.6	-0.9	-1.2	-0.1
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.5	-0.7	-0.3	-0.7	-0.3	-0.2	-0.1
Myopia	0.9	1.3	4.1	-1.7	-0.1	2.0	0.7	-0.8	-1.2	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.1	-0.9	0.1	-1.8	-1.4	-1.2	0.1	0.9
Cholesterol lowering medication	0.5	0.7	1.8	0.4	-0.7	-0.1	-0.2	-1.4	-1.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.7	-0.4	-0.5	-0.6	-1.3	-0.7	0.2	-0.5
Pain experienced in last month	0.7	1.2	2.2	1.0	0.2	-1.5	-1.5	-0.9	-0.5	-1.4
Supplements: Calcium	0.8	0.8	2.2	0.2	1.3	0.2	-0.9	0.3	1.5	-1.0
Basal cell carcinoma (self-reported)	0.7	0.9	1.9	-0.2	-0.8	-1.4	0.2	-1.3	0.4	-1.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.4	1.8	-0.6	0.8	-0.9	0.3	0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	7.9	1.8	0.1	1.0	-0.4	-0.9	2.8	0.4
Heart disease (siblings)	0.9	1.1	3.3	-0.5	1.8	-0.2	-1.3	-0.7	-0.8	-1.0
Alcohol drinker status: Previous	0.6	0.7	2.9	-1.7	0.4	-0.3	-0.8	-0.4	-0.6	-0.6
Pack years of smoking	0.4	0.6	2.1	0.7	1.0	0.2	1.4	0.5	-0.4	0.2
Impedance of whole body	0.1	0.7	3.0	-0.3	0.1	-0.3	0.5	1.7	0.4	1.1
Leg fat mass (left)	0.3	1.1	4.3	1.1	0.2	0.2	2.1	1.1	-0.8	-0.7
Arm predicted mass (left)	0.4	2.3	5.3	1.4	-1.5	-0.7	-0.3	-1.8	-1.7	-2.3