[Hub]/) : Traits : Heel T-Score : ←

chr22:49,471,519-51,219,006

Best TWAS P=8.61e-15 · Best GWAS P=1.28e-17 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ALG12	0.04	0.03	lasso	2	0.02	7.6e-04	-5.2	-6.7	2.5e-11	0.12	0.03	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CRELD2	0.03	0.01	lasso	5	0.02	2.9e-03	-5.5	-7.2	7.4e-13	0.11	0.05	0.82	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MLC1	0.05	0.01	blup	412	0.02	8.2e-04	1.3	6.1	1.3e-09	-0.42	0.12	0.54	TRUE
4	CommonMind	Brain Pre-frontal Cortex	PPP6R2	0.14	0.02	blup	369	0.09	5.9e-11	-8.5	-6.6	5.4e-11	0.68	0.01	0.99	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TUBGCP6	0.14	0.10	lasso	5	0.10	6.3e-12	-6.0	-6.2	5.5e-10	0.18	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	PPP6R2	0.19	0.09	enet	7	0.03	7.8e-03	4.7	-5.6	1.8e-08	0.29	0.19	0.08	FALSE
7	GTEx	Adipose Visceral Omentum	ALG12	0.14	0.01	lasso	6	0.03	1.4e-02	-8.1	-7.8	8.6e-15	0.09	0.01	0.96	TRUE
8	GTEx	Artery Aorta	PPP6R2	0.14	0.14	lasso	3	0.16	2.8e-09	4.7	-5.3	1.0e-07	0.22	0.99	0.00	FALSE
9	GTEx	Artery Tibial	SELO	0.09	0.05	lasso	4	0.06	1.8e-05	-6.1	-6.0	1.7e-09	0.17	0.81	0.01	FALSE
10	GTEx	Artery Tibial	PPP6R2	0.14	0.07	lasso	4	0.08	5.6e-07	4.7	-5.6	1.7e-08	0.30	0.97	0.00	FALSE
11	GTEx	Artery Tibial	CRELD2	0.09	0.09	lasso	1	0.08	1.5e-06	-5.6	-5.6	2.3e-08	0.10	0.97	0.01	FALSE
12	GTEx	Brain Cerebellar Hemisphere	ZBED4	0.17	0.15	lasso	2	0.17	3.6e-05	-5.6	5.6	1.8e-08	-0.10	0.12	0.58	FALSE
13	GTEx	Brain Cerebellum	TUBGCP6	0.37	0.00	lasso	6	0.01	1.5e-01	-5.1	-7.7	1.8e-14	0.16	0.07	0.06	TRUE
14	GTEx	Brain Cerebellum	TRABD	0.32	0.01	lasso	8	0.07	5.3e-03	3.0	-5.5	4.3e-08	0.18	0.10	0.08	TRUE
15	GTEx	Brain Hypothalamus	BRD1	0.36	-0.01	lasso	11	-0.01	5.0e-01	-7.5	-6.5	5.6e-11	0.11	0.03	0.67	FALSE
16	GTEx	Breast Mammary Tissue	ALG12	0.24	-0.01	lasso	9	0.03	8.6e-03	-8.1	-6.7	2.2e-11	0.17	0.02	0.97	FALSE
17	GTEx	Breast Mammary Tissue (Female)	ALG12	0.20	-0.01	lasso	7	-0.01	8.6e-01	-6.7	-6.4	1.2e-10	0.15	0.04	0.70	FALSE
18	GTEx	Breast Mammary Tissue (Female)	CRELD2	0.07	-0.01	lasso	6	-0.01	6.5e-01	-6.0	-5.8	6.2e-09	0.11	0.07	0.12	FALSE
19	GTEx	Colon Sigmoid	CRELD2	0.20	0.07	lasso	6	0.04	1.7e-02	-7.0	-7.3	2.0e-13	0.11	0.02	0.90	FALSE
20	GTEx	Colon Transverse	ACR	0.18	0.01	lasso	7	0.04	4.0e-03	2.0	-7.2	7.3e-13	0.60	0.02	0.69	TRUE
21	GTEx	Colon Transverse	CRELD2	0.17	0.11	enet	9	0.10	2.2e-05	-6.6	-6.8	1.1e-11	0.07	0.61	0.33	FALSE
22	GTEx	Esophagus Mucosa	SELO	0.19	0.10	lasso	4	0.08	2.7e-06	-6.0	-6.1	1.3e-09	0.19	0.95	0.00	TRUE
23	GTEx	Nerve Tibial	ALG12	0.13	0.04	lasso	6	0.05	2.5e-04	-6.6	-6.5	8.5e-11	0.10	0.14	0.84	FALSE
24	GTEx	Pancreas	TRABD	0.22	-0.01	lasso	5	0.01	1.2e-01	-1.4	6.9	5.0e-12	-0.32	0.05	0.14	FALSE
25	GTEx	Pancreas	ALG12	0.22	0.15	lasso	4	0.15	7.9e-07	-5.7	-5.7	1.0e-08	0.09	0.76	0.16	FALSE
26	GTEx	Pancreas	RP3-402G11.26	0.20	0.04	lasso	4	0.02	4.1e-02	5.4	5.4	6.1e-08	-0.40	0.06	0.11	FALSE
27	GTEx	Stomach	SELO	0.13	0.08	lasso	2	0.05	2.1e-03	-6.1	-5.8	6.1e-09	0.18	0.21	0.05	FALSE
28	GTEx	Thyroid	SELO	0.15	0.06	lasso	3	0.06	2.1e-05	-6.1	-7.4	1.9e-13	0.22	0.64	0.05	TRUE
29	GTEx	Whole Blood	ZBED4	0.10	0.02	lasso	5	0.03	1.0e-03	-5.8	-6.8	1.3e-11	0.12	0.07	0.79	FALSE
30	NTR	Blood	CRELD2	0.02	0.02	lasso	2	0.02	2.9e-06	-6.6	-7.0	2.8e-12	0.10	0.08	0.92	FALSE
31	YFS	Blood	CRELD2	0.12	0.22	lasso	9	0.23	3.4e-73	-5.8	-6.3	2.6e-10	0.12	1.00	0.00	FALSE
32	YFS	Blood	PLXNB2	0.02	0.02	lasso	4	0.02	3.6e-07	4.7	-6.2	5.0e-10	0.40	0.95	0.04	TRUE
33	YFS	Blood	SBF1	0.11	0.04	blup	303	0.06	4.3e-19	5.2	6.0	1.9e-09	-0.38	1.00	0.00	FALSE
34	YFS	Blood	ZBED4	0.04	0.03	enet	15	0.04	4.4e-12	-7.9	-7.1	1.3e-12	0.11	0.03	0.97	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SELO	0.05	0.01	blup	49	0.03	7.6e-04	-3.9	-5.4	6.2e-08	0.20	0.10	0.49	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CRELD2	0.03	0.02	blup	38	0.02	3.2e-03	-5.9	-5.6	1.9e-08	0.09	0.23	0.18	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SELO	0.04	0.03	lasso	3	0.03	2.0e-04	-6.9	-7.0	3.6e-12	0.23	0.00	0.98	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALG12	0.03	0.00	blup	43	0.02	2.8e-03	-7.8	-7.1	9.4e-13	0.12	0.02	0.84	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	SELO	0.04	0.02	enet	7	0.03	3.5e-04	-6.0	-5.3	1.2e-07	0.08	0.15	0.57	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	CRELD2	0.04	0.06	lasso	1	0.06	1.7e-06	-5.5	-5.5	3.6e-08	0.12	0.88	0.09	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	SELO	0.07	0.04	blup	49	0.03	2.2e-04	-6.1	-7.0	2.0e-12	0.24	0.06	0.78	TRUE
42	The Cancer Genome Atlas	Skin Cutaneous Melanoma	BRD1	0.17	-0.01	blup	45	0.01	1.4e-01	-4.2	5.4	5.4e-08	-0.09	0.01	0.26	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	SELO	0.07	0.06	lasso	5	0.05	5.9e-06	-6.1	-5.8	5.2e-09	0.19	0.12	0.84	FALSE