TWAS hub - TUBGCP6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1430	0.0390	1.7e-07	0.103	0.077	0.088	0.092	0.098	1.6e-12	1.2e-09	8.1e-11	2.7e-11	6.3e-12
2	GTEx	Brain Cerebellum	0.3750	0.1220	2.1e-03	-0.003	NA	-0.001	NA	0.011	4.0e-01	NA	3.4e-01	NA	1.5e-01
3	GTEx	Brain Hypothalamus	0.4880	0.1420	4.5e-03	0.035	NA	-0.012	NA	0.006	5.2e-02	NA	8.7e-01	NA	2.3e-01
4	GTEx	Lung	0.1044	0.0428	5.8e-03	0.021	NA	0.021	NA	0.014	8.5e-03	NA	9.5e-03	NA	2.6e-02
5	GTEx	Skin Sun Exposed Lower leg	0.0790	0.0370	7.1e-03	0.040	NA	0.033	NA	0.027	2.6e-04	NA	9.0e-04	NA	2.6e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0521	0.0266	3.4e-04	0.012	0.037	0.034	NA	0.028	1.3e-02	5.2e-05	8.8e-05	NA	3.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	9.2	106.3	210.2	13.4	14.3	-1.0	14.5	4.3	-4.9
Medication: Lisinopril	4.8	6.2	13.9	-3.7	-2.1	1.0	-3.2	0.5	2.8
Neck or shoulder pain in last month	4.3	6.2	12.6	3.6	3.2	1.1	2.8	0.3	-2.3
Alcohol intake versus 10 years previously	3.8	5.6	11.9	2.5	2.1	0.8	1.0	-3.1	-3.4
Depression (self-reported)	3.7	4.4	11.0	2.1	3.3	-0.6	2.9	0.7	-1.2
Loud music exposure frequency	3.7	4.1	6.4	2.5	2.0	1.2	2.2	-1.2	-2.5
Loneliness, isolation	3.7	5.1	11.6	2.3	1.4	-2.5	3.4	-1.4	-2.0
Medication: Metformin	3.5	4.9	14.6	-2.2	-2.6	0.3	-1.9	-3.8	0.3
Alcohol intake frequency.	3.4	7.9	17.3	4.0	4.2	-0.1	2.4	-0.0	-2.9
Shortness of breath walking on level ground	3.0	3.5	10.1	2.4	2.0	1.1	3.2	0.4	-0.6
Unable to work because of sickness or disability	3.0	3.9	8.6	1.9	1.9	-0.1	2.9	-2.7	-0.9
Sensitivity / hurt feelings	2.9	5.0	7.9	-2.8	-1.1	1.3	-1.9	2.8	2.8
Other serious medical condition/disability diagnosed by doctor	2.9	3.8	7.4	2.7	2.6	-0.2	1.3	0.5	-2.6
Heel T-Score	2.8	22.5	58.7	-6.2	-7.7	-2.2	-4.9	0.3	3.0
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	6.0	2.1	2.5	-1.1	2.3	0.4	-1.6
Number of operations (self-reported)	2.6	3.9	19.3	-0.7	1.1	0.4	-0.5	4.4	1.3
Time employed in main current job	2.5	2.9	8.6	-1.4	-1.3	-2.9	-1.6	-0.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.1	5.8	1.9	2.4	-2.4	1.9	-0.1	-0.4
Overall health rating	2.4	5.2	8.7	2.9	2.9	0.6	2.4	-1.9	-2.1
Medication: Aspirin	2.4	3.2	5.5	-2.4	-2.2	0.8	-1.8	-1.3	1.7
Hearing difficulty/problems with background noise	2.3	3.6	6.3	1.2	2.5	2.5	1.0	-1.9	-1.9
Ever had prostate specific antigen (PSA) test	2.3	2.6	5.5	-2.4	-1.6	-0.3	-1.7	1.7	1.4
Diabetes (mother)	2.2	2.8	5.5	-1.5	-1.9	2.3	-1.2	-1.9	0.6
Medication: Amlodipine	2.2	3.1	6.2	-2.5	-1.0	0.5	-2.3	0.2	2.4
Supplements: Zinc	2.1	2.3	4.9	0.8	2.2	2.1	0.7	-0.5	-1.8
Medication: Aspirin	2.1	2.8	5.3	-2.1	-1.7	1.2	-2.3	-1.1	1.1
Ever had hysterectomy (womb removed)	2.0	2.3	4.9	-1.7	-2.2	-1.4	-0.2	-0.6	1.9
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	7.2	1.8	2.7	-0.1	2.1	-1.5	-1.5
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	5.2	2.2	2.3	-0.4	1.0	0.4	-1.6
Ever highly irritable/argumentative for 2 days	2.0	2.4	5.4	2.3	1.8	0.8	2.2	-0.6	-0.1
Ever depressed for a whole week	2.0	2.5	5.3	2.1	1.7	0.5	2.3	-0.4	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	5.7	2.4	2.1	0.4	2.4	-0.5	-1.4
Alzheimer’s Disease (in mother)	1.8	2.1	9.4	1.2	3.1	0.4	1.1	-0.4	-0.7
Chronotype (morning person)	1.8	4.1	7.9	-2.0	-0.9	-1.7	-1.1	2.8	2.8
Systolic blood pressure, automated reading	1.8	5.2	10.0	-3.0	-3.2	-0.5	-2.4	-0.5	2.4
Exposure to tobacco smoke at home	1.8	2.0	4.5	-1.5	0.3	1.4	-2.1	1.6	1.1
LDL Cholesterol	1.7	2.6	4.9	1.6	1.4	1.5	1.1	-2.2	-1.6
Triglycerides	1.7	2.7	9.3	1.6	1.4	3.1	1.1	1.0	-0.6
Chronic bronchitis/emphysema (father)	1.7	1.9	5.3	2.3	1.3	1.2	1.1	-0.0	-1.5
Had other major operations	1.7	2.1	8.0	0.4	1.7	0.5	0.8	2.8	0.8
Family relationship satisfaction	1.7	2.1	5.3	1.5	1.9	-0.6	2.3	-0.8	-0.4
Medication: Gliclazide	1.7	1.9	3.4	-1.7	-1.7	-0.9	-0.3	-1.9	1.2
Leg fat percentage (left)	1.7	6.1	11.8	-2.7	-3.0	1.0	-3.4	-1.7	2.0
Depressed Affect (Nagel 2018)	1.6	3.3	8.8	0.9	1.6	-3.0	2.6	-0.7	-0.6
Body fat percentage	1.6	6.2	13.8	-2.9	-3.1	0.5	-3.7	-1.0	2.1
Exposure to tobacco smoke outside home	1.6	2.1	5.4	-2.3	-1.3	-0.9	-1.2	-0.5	1.7
Heart disease (mother)	1.6	2.0	8.2	0.1	0.3	2.9	-0.9	-1.6	-0.2
Friendships satisfaction	1.6	2.0	4.6	2.1	1.9	-0.2	1.3	-1.3	-0.9
Wears glasses or contact lenses	1.6	1.9	3.7	1.7	1.9	1.6	1.3	-0.5	-0.4
Alcohol drinker status: Previous	1.6	1.8	5.6	1.5	2.4	0.6	0.9	0.2	-1.3
Depression (Nagel 2018)	1.5	2.3	8.6	1.2	1.7	-2.9	0.7	0.2	-0.5
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.0	-2.2	-1.2	0.7	-2.0	-2.5	0.4
Maternal smoking around birth	1.5	2.1	5.6	2.0	1.2	-0.7	2.4	-0.2	-1.0
Financial difficulties in last 2 years	1.5	2.0	5.4	1.5	2.3	1.4	1.3	0.4	-0.9
Diastolic blood pressure, automated reading	1.5	4.6	9.0	-3.0	-2.6	-0.7	-2.4	-0.2	2.3
Alzheimer’s Disease (including proxy)	1.4	2.1	8.7	0.7	2.9	0.4	0.8	1.6	0.0
Frequency of depressed mood in last 2 weeks	1.4	1.9	9.0	0.6	1.2	-3.0	0.1	-0.6	-0.2
Diabetes (self-reported)	1.4	2.2	6.0	-1.8	-0.9	1.0	-1.4	-2.4	0.4
Health satisfaction	1.4	1.8	4.0	2.0	1.7	-0.4	1.7	-0.3	-0.9
Hypertension (Self-reported)	1.4	3.9	7.5	-2.7	-1.2	1.5	-2.4	-1.0	2.2
Medication: Blood pressure	1.4	2.6	4.3	-2.1	-0.8	1.8	-1.9	-0.3	2.0
Trunk fat percentage	1.3	5.2	11.9	-2.7	-2.7	0.2	-3.4	-0.7	2.1
Hair/balding pattern: Pattern 2	1.3	1.6	3.7	1.3	1.5	-1.0	1.0	0.3	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	12.2	-1.5	-3.5	-0.4	-1.3	-0.8	0.9
Birth weight	1.3	2.8	8.8	-1.2	0.3	1.1	0.4	3.0	2.2
Leg fat percentage (right)	1.3	4.8	9.6	-2.3	-2.6	1.4	-3.1	-1.6	1.6
Arm fat percentage (left)	1.3	5.1	12.1	-2.3	-3.0	0.1	-3.5	-1.4	1.3
Myopia	1.3	1.9	3.6	1.6	1.5	-0.2	1.9	-0.8	-1.4
High blood pressure	1.2	3.4	6.7	-2.6	-1.0	1.5	-2.3	-0.7	2.2
Arm fat percentage (right)	1.2	4.8	12.1	-2.3	-2.9	0.1	-3.5	-1.2	1.3
Number of children fathered	1.2	1.4	2.8	-1.7	-1.1	-0.4	-1.3	-0.3	1.6
Supplements: Vitamin C	1.2	1.5	2.7	1.5	1.4	0.1	0.9	-0.9	-1.6
Diabetes diagnosed by doctor	1.2	2.0	6.3	-1.5	-1.4	0.4	-1.2	-2.5	0.3
Guilty feelings	1.2	1.8	6.1	0.7	2.5	1.4	1.0	-0.6	-0.8
Financial situation satisfaction	1.2	1.5	5.4	1.5	0.8	-0.1	2.3	0.7	0.3
Average weekly beer plus cider intake	1.2	1.7	3.9	-1.5	-2.0	-0.3	-0.3	0.4	2.0
Commuting to job workplace: Cycle	1.2	1.5	6.0	-1.2	-1.1	-0.4	-2.4	0.4	0.0
Schizophrenia (2014)	1.1	2.4	9.1	1.4	3.0	-0.2	0.9	0.0	-1.6
Systolic Blood Pressure	1.1	5.6	11.6	-3.0	-3.4	-0.3	-2.2	-0.6	2.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.7	1.4	1.9	-0.2	1.4	-0.1	-0.7
Had menopause	1.1	1.4	5.6	0.3	0.3	1.2	0.1	2.4	1.2
Number of live births	1.1	1.5	2.7	-1.4	-1.6	1.0	-1.4	0.5	1.2
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.3	-2.1	-1.0	-0.0	-1.8	1.8	1.7
Medication: Cholesterol lowering	1.1	1.8	4.1	-1.3	-0.7	1.0	-1.6	-2.0	0.8
Comparative body size at age 10	1.1	3.1	8.1	-2.3	-2.9	-0.9	-0.7	-0.6	1.8
Pulse wave peak to peak time	1.1	1.3	2.2	1.5	-0.0	-0.7	1.2	1.2	-1.5
Emphysema/chronic bronchitis	1.1	1.3	3.9	-0.9	0.9	0.3	0.0	2.0	1.4
Medication: Allopurinol	1.1	1.4	4.7	-0.6	-1.4	-1.1	0.7	-2.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.8	-0.7	-1.7	-0.9	-1.6	0.9	-0.3
Average weekly champagne plus white wine intake	1.1	1.5	3.1	-1.4	-0.9	-0.8	-0.6	1.5	1.7
Commuting to job workplace: Public transport	1.1	1.3	3.0	1.2	1.6	-0.4	0.7	1.7	0.1
Irritability	1.1	1.9	5.6	-1.3	1.0	-0.5	-0.4	2.4	1.6
Vascular/heart problems diagnosed by doctor	1.1	2.9	4.6	2.1	0.4	-1.9	2.1	1.1	-1.8
Fasting Glucose	1.0	1.2	3.4	-0.5	-1.3	1.8	0.3	-1.1	0.7
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.3	-0.1	-0.5	1.4	-0.6	-2.1	0.3
Blood Red Count	1.0	9.7	32.9	-1.7	-2.0	-5.7	-1.0	3.7	1.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	0.7	1.2	1.3	0.5	-1.1	-1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.7	-1.1	-1.3	0.0	0.8	-0.2	1.9
Illnesses of mother	1.0	1.3	3.9	0.4	0.3	-1.7	0.6	2.0	-0.1
Pulse wave Arterial Stiffness index	1.0	1.1	2.6	-1.4	0.1	0.6	-1.0	-0.9	1.6
Birth weight of first child	1.0	1.8	7.1	-0.3	0.1	-1.1	1.0	2.7	1.2
Pulse wave reflection index	1.0	1.3	2.9	-1.7	-0.8	0.2	-1.6	-0.4	1.2
Mood swings	1.0	1.8	6.9	-1.3	-0.1	-2.6	0.6	0.1	1.3
Long-standing illness, disability or infirmity	1.0	1.6	3.9	2.0	1.1	-0.0	1.6	-0.8	-1.1
Medication: Atorvastatin	1.0	1.2	4.0	-1.4	-0.4	-0.0	-0.9	-2.0	0.6
Ovarian Cancer	0.9	1.2	3.8	1.4	0.8	-0.1	1.9	0.1	-0.9
Prostate Cancer	0.9	1.3	2.9	1.7	1.2	-0.6	0.9	-0.2	-1.6
BMI	0.9	5.1	14.2	-2.9	-1.8	0.7	-3.8	-0.5	2.0
Severe depression (siblings)	0.9	1.1	1.6	1.2	1.3	-0.1	0.9	-1.0	-1.2
Qualifications: CSEs or equivalent	0.9	1.2	3.5	-0.2	-1.3	1.0	0.1	-1.9	-1.1
Alcohol usually taken with meals	0.9	1.5	7.3	-0.1	-0.4	0.6	-0.2	2.7	1.0
Pain all over the body in last month	0.9	0.9	2.2	0.7	1.5	-0.7	1.1	-1.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.5	-1.1	-1.0	1.2	-1.2	-0.7	0.7
Mineral and other dietary supplements	0.9	1.2	4.2	-1.0	0.0	0.8	-2.0	-0.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	8.6	-0.4	-0.1	1.2	-0.8	-2.9	-0.5
Miserableness	0.9	1.5	4.5	0.4	1.1	-2.1	1.7	-0.2	-0.4
High cholesterol (Self-reported)	0.9	1.6	2.7	-1.4	-1.6	0.5	-1.6	-1.0	1.1
Heart disease (siblings)	0.9	1.1	2.9	-1.0	-0.9	-1.7	-0.2	-1.0	0.8
Schizophrenia (2018)	0.8	1.7	7.1	0.7	2.7	-0.4	0.6	-1.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.8	2.0	6.1	-0.8	0.5	0.4	-0.9	2.5	2.0
HbA1C	0.8	0.9	2.1	-0.9	-1.4	-0.9	0.2	-0.2	1.3
Lupus	0.8	1.2	2.6	-1.6	-0.4	-0.6	-1.1	0.6	1.6
Lung FEV1/FVC ratio	0.8	4.3	9.1	-1.9	-2.2	1.4	-3.0	-2.5	-0.1
Hearing difficulty/problems: Yes	0.8	1.2	3.3	1.0	1.8	0.9	0.8	1.1	0.2
Vitamin and mineral supplements	0.8	1.1	2.7	-1.1	-0.9	-0.1	-1.7	0.8	1.1
Medication: Lansoprazole	0.8	0.9	3.1	0.0	0.0	0.8	0.4	1.8	1.3
Glaucoma (self-reported)	0.8	0.9	3.8	-1.1	-0.2	-0.3	-1.9	0.6	0.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.0	0.6	1.3	-0.2	0.1	-1.7	-0.8
Qualifications: College or University degree	0.8	2.4	9.3	-0.7	0.1	1.3	-1.7	3.0	0.2
Medication: Blood pressure	0.8	1.4	3.5	-1.9	0.0	0.1	-1.1	-0.2	1.8
Angina (self-reported)	0.8	1.0	3.2	0.6	0.9	1.8	0.3	-1.3	-0.0
Comparative height size at age 10	0.8	4.6	12.2	2.4	3.5	-0.4	2.8	0.8	-1.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	-1.3	-1.3	-1.1	-0.5	0.1	1.0
Eye problems/disorders: Cataract	0.8	0.9	3.3	1.1	0.6	0.7	0.2	-0.5	-1.8
Medication for cholesterol	0.8	1.2	3.3	1.0	0.7	-1.8	0.9	-0.0	-1.2
Eye problems/disorders: Glaucoma	0.8	1.0	2.8	-0.8	-0.3	-1.4	-1.7	0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.0	0.1	-0.8	-1.7	1.4	-0.2	-0.5
Alcohol drinker status: Never	0.8	0.9	5.1	0.1	0.2	-2.2	-0.5	0.5	0.4
Basal cell carcinoma (self-reported)	0.8	1.0	2.8	0.1	0.6	1.5	0.2	1.7	0.7
Leg fat mass (left)	0.8	3.0	6.6	-1.9	-1.6	1.1	-2.6	-1.5	1.5
Bipolar Disorder (2018)	0.7	1.1	5.3	0.1	0.8	-0.3	-0.5	2.3	-0.1
Neuroticism (Nagel 2018)	0.7	1.7	3.8	0.6	2.0	-1.9	1.6	0.3	-0.0
Age at First Birth	0.7	1.0	3.7	-1.1	0.1	-1.9	-0.9	-0.2	0.5
Crohns Disease (2012)	0.7	1.2	2.9	0.0	1.7	-1.4	-0.4	1.5	0.3
Blood Eosinophil Count	0.7	5.0	14.1	3.8	3.0	0.6	1.4	1.0	-1.9
Angina	0.7	0.9	2.4	0.8	1.0	1.5	0.3	-1.2	-0.2
Current tobacco smoking	0.7	1.1	4.4	0.3	0.1	-1.0	2.1	0.5	1.0
Fed-up feelings	0.7	1.3	2.8	-0.8	0.6	-1.3	1.7	-0.3	1.5
Taking other prescription medications	0.7	1.0	2.8	1.4	0.8	-0.7	1.7	-0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.2	-1.1	-2.0	-0.6	-1.4	1.1	1.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.0	-0.4	-0.4	1.4	-1.4	0.2	0.0
Multivitamins +/- minerals	0.7	0.9	2.6	0.7	0.6	0.5	0.3	-1.2	-1.6
High blood pressure (mother)	0.7	1.0	3.7	0.2	0.8	1.9	0.8	0.8	-0.8
Trunk fat mass	0.7	2.8	7.0	-1.9	-1.7	0.2	-2.6	-0.7	1.7
Forced vital capacity (FVC)	0.7	2.6	8.6	1.4	1.9	0.7	2.9	-0.7	-0.5
Qualifications: None of the above	0.7	1.6	6.3	-0.2	-0.6	-2.5	0.8	-0.8	1.2
Medication: Ramipril	0.7	1.0	2.1	-0.7	-1.4	-1.0	0.9	-0.6	0.9
Medication: Simvastatin	0.7	1.0	3.2	-0.4	-0.5	1.8	-1.1	-0.8	0.6
Happiness	0.7	0.8	1.4	1.1	1.1	-0.8	1.2	0.7	-0.2
Forced vital capacity (FVC), Best measure	0.7	2.6	8.7	1.3	1.7	0.7	3.0	-1.2	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.1	-1.2	-0.2	0.1	-0.1	-1.8	0.7
Eye problems/disorders: None of the above	0.7	0.8	1.4	0.1	-1.2	-0.8	1.0	-0.4	1.2
Medication: Ibuprofen	0.7	0.9	2.5	0.6	0.7	-0.7	1.6	1.1	-0.1
Medication: Omeprazole	0.7	0.9	2.6	0.6	1.2	-0.4	-0.3	-1.6	-0.9
Whole body fat mass	0.7	2.8	7.2	-1.8	-1.5	0.8	-2.7	-0.9	1.5
Number of full sisters	0.7	0.8	3.1	-0.5	-0.8	-0.7	-0.6	-1.8	-0.4
Had major operations	0.7	0.9	2.2	-1.0	-0.5	1.1	-1.5	0.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.9	-1.3	-1.4	0.2	-0.1	-0.8	0.9
Breast cancer (self-reported)	0.7	0.8	1.8	-0.2	0.8	1.4	-0.8	1.2	0.3
Ever taken oral contraceptive pill	0.7	0.8	2.6	0.3	-0.9	1.6	-0.5	-0.7	-0.7
Fractured/broken bones in last 5 years	0.7	0.9	2.0	-0.1	1.4	-1.2	1.0	0.6	0.7
Supplements: Calcium	0.7	0.8	1.9	1.1	0.9	0.6	1.4	0.2	-0.6
Bipolar Disorder or Schizophrenia	0.6	1.4	6.8	0.6	2.6	-0.4	0.1	0.7	-0.8
Relative age of first facial hair	0.6	1.3	3.2	0.4	0.8	-1.8	1.4	1.3	0.2
Medication: Co-codamol	0.6	0.7	2.4	1.1	0.3	1.6	-0.0	0.8	-0.2
Townsend deprivation index at recruitment	0.6	0.8	2.9	0.6	1.7	-0.7	1.1	0.1	0.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.2	1.8	0.3	-1.2	0.7	0.6	-1.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.4	1.2	0.9	1.2	-0.4	-0.3	-0.8
Medication: Atenolol	0.6	0.7	1.6	-1.2	-0.4	0.8	-0.9	-0.2	1.0
Body mass index (BMI)	0.6	2.4	5.6	-1.6	-1.7	0.7	-2.4	-1.4	0.9
Mouth/teeth dental problems	0.6	0.9	2.0	-1.1	-0.6	-1.4	-0.8	0.6	0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.1	0.6	-0.0	-1.8	0.7	-0.9	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.6	0.3	0.2	-0.0	1.9	0.7	0.1
Lung cancer (father)	0.6	0.7	1.5	-1.2	-0.1	0.9	-1.2	0.3	0.3
Standing height	0.6	5.6	16.7	2.5	4.1	0.0	2.9	1.3	-0.8
Length of working week for main job	0.6	0.7	2.1	-0.7	0.4	-0.4	-1.4	-1.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	3.2	1.0	0.7	0.2	1.8	0.7	-0.8
Gout (self-reported)	0.6	0.8	2.8	-0.1	-0.3	-1.1	0.6	-1.7	0.1
High blood pressure (siblings)	0.6	0.8	2.5	-1.6	-0.9	0.1	-0.9	-0.6	0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	-0.4	-0.4	-0.1	1.4	-0.3	1.3
Leg fat mass (right)	0.6	2.5	5.6	-1.5	-1.3	1.4	-2.4	-1.4	1.2
Suffer from ‘nerves’	0.6	0.9	2.6	0.7	0.9	-0.7	1.6	0.8	0.5
Average weekly red wine intake	0.6	0.8	1.5	-1.2	-0.3	0.1	-1.2	1.0	1.0
Ever had bowel cancer screening	0.6	0.7	2.1	1.4	0.6	-0.5	0.8	-0.3	-0.8
Qualifications: nursing, teaching	0.6	1.0	2.1	0.2	-0.1	1.1	-1.3	-0.8	-1.4
Commuting to job workplace: Walk	0.6	0.6	1.5	-0.1	-0.8	-0.6	0.3	1.0	1.2
Osteoporosis (self-reported)	0.6	0.7	1.8	-0.1	0.3	-1.2	0.7	1.4	0.8
Osteoarthritis (self-reported)	0.6	0.7	2.5	0.7	-0.8	-1.6	0.6	0.7	-0.2
Smoking status: Current	0.6	1.0	2.9	-0.0	-0.3	-1.0	1.7	0.6	1.3
Number of self-reported non-cancer illnesses	0.6	1.0	2.7	-1.0	0.4	1.6	-0.6	0.3	1.2
Ever smoked	0.6	1.0	2.3	0.2	1.5	-0.2	1.2	1.4	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.7	-0.0	1.3	0.6	-0.9	2.2	1.1
Crohns Disease (2017)	0.5	1.1	3.5	0.3	1.9	-1.4	-0.7	0.5	-0.4
Reaction Time	0.5	0.9	1.9	0.7	0.6	0.9	0.0	-1.2	-1.4
Body Mass Index (BMI) (2010)	0.5	0.6	1.8	-0.8	-1.3	-0.5	-0.6	-0.7	0.6
HDL Cholesterol	0.5	0.8	2.4	0.3	-0.1	-0.4	-0.8	-1.5	-1.3
Smoking Status	0.5	1.1	2.1	-0.9	-0.3	-1.0	1.1	1.2	1.5
Cardiovascular Disease	0.5	1.6	3.4	-1.4	-0.4	1.8	-1.0	-1.4	1.0
Hand grip strength (left)	0.5	1.3	6.7	-0.5	2.6	0.3	-0.2	0.8	-0.1
Medication for hormone replacement therapy	0.5	0.6	1.4	0.7	1.2	-0.3	0.8	-0.3	-0.8
Nervous feelings	0.5	0.9	3.5	-0.3	1.1	0.5	0.1	1.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.4	-0.1	1.6	-1.2	0.7	-0.1	-0.2
Neuroticism score	0.5	1.0	1.5	-1.0	1.2	-1.0	0.9	0.5	1.2
Trunk fat-free mass	0.5	3.1	9.5	2.1	3.1	0.2	1.9	-0.0	-1.0
Mouth/teeth dental problems: Dentures	0.5	0.9	1.6	1.2	1.3	1.2	-0.0	-0.7	-0.5
Asthma	0.5	1.0	2.7	1.3	0.8	0.5	1.6	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.8	3.3	0.8	1.1	1.3	1.8	-1.8	-0.7
Arm fat mass (right)	0.5	2.0	6.1	-1.4	-1.4	0.4	-2.5	-1.0	1.0
Trunk predicted mass	0.5	3.0	9.6	2.1	3.1	0.2	1.8	0.0	-1.0
Breastfed as a baby	0.5	0.6	1.7	-0.1	-0.7	1.1	-1.3	-0.2	-0.2
Tense / ‘highly strung’	0.5	0.8	1.9	0.1	1.0	-1.3	-0.2	1.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	0.4	0.8	1.5	-0.7	0.7	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.2	1.1	0.3	-0.9	1.0	1.1	-1.0
Leg pain on walking	0.5	0.6	3.1	0.0	-0.7	0.4	-0.5	-1.7	-0.0
Hearing aid user	0.5	0.6	1.6	1.1	0.5	-0.6	0.5	0.0	-1.3
Cholesterol lowering medication	0.5	0.7	2.6	-0.3	-0.4	1.6	-0.7	-0.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.9	1.4	0.6	1.0	0.8	-0.4	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	2.4	0.0	0.1	0.4	0.5	-1.5	-0.1
Alzheimer’s Disease (in father)	0.4	0.4	1.9	-0.2	0.6	0.4	-0.1	1.4	-0.0
Irritable Bowel Disease (IBD)	0.4	1.0	2.8	0.6	1.7	-1.5	0.2	0.3	-0.4
Rheumatoid Arthritis	0.4	0.5	1.9	0.6	0.1	0.7	1.4	0.6	0.1
Blood White Count	0.4	2.8	9.5	2.0	0.9	-1.2	1.2	3.1	-0.4
Height	0.4	6.9	22.6	2.9	4.8	-0.2	3.0	1.0	-0.6
Allergy or Eczema	0.4	1.2	2.1	1.5	0.5	-1.1	-0.2	1.4	-1.2
Hypothyroidism (self reported)	0.4	0.8	3.0	0.2	-0.2	1.2	-0.5	-1.7	-0.5
Respiratory disease	0.4	0.9	2.7	0.9	1.1	1.6	0.8	0.5	-0.1
Neuroticism	0.4	1.0	2.7	-1.0	0.8	-1.6	1.0	0.3	1.0
Average weekly spirits intake	0.4	0.5	1.0	-0.6	-0.7	0.1	-0.8	-1.0	-0.5
Pack years adult smoking proportion	0.4	0.5	2.3	0.2	-0.2	0.7	0.3	-1.5	-0.5
Hand grip strength (right)	0.4	1.0	3.4	-1.0	1.8	-0.2	0.3	1.2	0.5
Supplements: Glucosamine	0.4	0.5	1.8	0.3	-0.6	-0.8	1.3	-0.3	-0.2
Medication: Levothyroxine sodium	0.4	0.6	1.7	1.1	0.9	-0.2	1.3	0.0	-0.1
Waist circumference	0.4	1.3	2.8	-0.9	-0.7	1.3	-1.7	-1.3	0.6
Number of incorrect matches in round	0.4	0.7	1.5	-1.2	-0.6	-0.1	-1.0	0.8	1.0
Allergy	0.4	0.8	2.4	-1.6	-0.9	0.2	-0.7	-0.6	0.9
Illnesses of siblings	0.4	0.6	2.1	0.4	0.5	1.0	0.1	1.4	-0.0
Falls in the last year	0.4	0.5	1.0	0.1	0.9	-0.8	1.0	-0.8	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.6	-0.5	1.1	-1.3	-0.6	0.1
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	0.4	0.6	1.5	-1.3	0.7	-0.1
Blood clot in the leg (DVT)	0.4	0.5	1.1	1.0	0.3	0.8	0.5	-0.7	-0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	-0.8	-1.1	-0.2	-0.3	-0.5	0.8
Wheeze or whistling in the chest in last year	0.4	0.8	3.7	-0.2	0.4	-1.9	0.4	-0.5	0.7
Age at first live birth	0.4	0.7	1.5	0.4	0.9	-1.1	-0.2	0.5	-1.2
Migraine (self-reported)	0.4	0.5	0.8	-0.7	-0.8	0.8	-0.5	0.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.6	-0.9	1.0	-0.7	0.2	-0.2
Arm predicted mass (right)	0.4	2.1	8.3	1.4	2.9	-0.1	1.2	-0.0	-0.7
Chest pain or discomfort	0.4	0.6	2.7	0.1	0.6	0.7	0.5	-1.7	-0.3
Knee pain experienced in last month	0.4	0.6	2.3	-0.3	0.4	1.5	-0.7	-0.7	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	0.3	0.1	1.1	0.7	0.1	1.1
Illnesses of father: Heart disease	0.4	0.6	2.9	0.4	1.7	0.2	0.5	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.2	0.6	1.1	-0.6	1.5	0.4	-0.1
Asthma (self-reported)	0.4	0.8	1.9	1.3	0.8	0.7	1.4	-0.1	-0.7
Arm fat mass (left)	0.4	1.7	5.1	-1.3	-1.2	0.2	-2.3	-1.0	0.9
Mother’s age at death	0.4	0.4	1.8	0.6	-0.4	-1.3	0.2	0.1	-0.5
Medication: Paracetamol	0.4	0.6	1.1	1.0	-0.0	-0.8	0.4	-0.6	-1.1
Arm fat-free mass (left)	0.4	1.9	7.3	1.5	2.7	0.0	1.1	0.2	-0.7
Worry (Nagel 2018)	0.3	0.7	2.1	0.2	1.4	-1.0	0.9	0.6	0.2
Breast Cancer	0.3	0.6	2.7	-0.1	-0.6	0.9	-0.3	-1.6	0.3
Relative age voice broke	0.3	0.5	1.4	0.8	0.6	-0.4	-0.1	-0.8	-1.2
Stomach or abdominal pain in last month	0.3	0.4	1.2	-0.4	-0.2	-0.4	-0.5	-1.1	-0.8
Sitting height	0.3	2.0	5.8	1.3	2.4	0.0	2.0	0.8	-0.4
Past tobacco smoking	0.3	0.5	2.0	-0.6	-1.4	0.3	-0.7	-0.3	0.2
Impedance of arm (right)	0.3	1.3	3.2	-1.1	-1.8	-0.4	-1.2	1.0	0.8
Hip circumference	0.3	1.3	2.4	-1.5	-0.9	0.7	-1.4	-1.2	1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.8	0.5	0.8	1.1	1.7	-1.0	-0.1
Impedance of arm (left)	0.3	1.3	3.7	-1.2	-1.9	-0.3	-1.3	0.5	0.8
Peak expiratory flow (PEF)	0.3	0.7	2.1	-0.6	1.4	0.5	0.7	-0.9	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.5	0.0	-0.7	1.2	0.2	0.3	0.4
Medication: Paracetamol	0.3	0.4	1.1	0.4	-0.6	-1.1	0.1	-0.7	-0.7
Arm fat-free mass (right)	0.3	1.6	6.4	1.3	2.5	0.0	1.2	-0.0	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.6	1.7	0.6	1.3	0.7	0.2	0.1	-0.9
Age at last live birth	0.3	0.4	1.0	-0.4	0.4	0.3	-1.0	0.9	0.0
Illnesses of siblings: Diabetes	0.3	0.3	1.3	-0.7	-0.1	-1.1	0.2	-0.2	0.1
Whole body fat-free mass	0.3	1.8	6.4	1.5	2.5	0.0	1.3	0.1	-0.6
Back pain experienced in last month	0.3	0.5	1.6	0.4	0.5	1.3	0.7	0.2	0.4
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	-0.2	-1.0	-0.7	-0.7	0.3	0.1
Whole body water mass	0.3	1.9	6.5	1.5	2.5	-0.1	1.3	-0.0	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	0.2	1.2	-0.3	0.4	-0.7	-0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.5	0.7	0.1	-0.5	0.7	-0.6	-0.7
Illnesses of father: High blood pressure	0.3	0.3	1.0	0.1	0.7	0.2	1.0	-0.8	-0.1
Age started oral contraceptive pill	0.3	0.3	0.9	-0.3	-0.7	0.9	-0.3	-0.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.4	0.4	1.2	-0.3	-0.1	-0.8	0.0
Pain experienced in last month	0.3	0.6	1.5	-0.3	-1.2	-1.0	-0.3	-0.8	-0.0
Pack years of smoking	0.3	0.5	2.1	-0.1	-0.4	0.8	-0.2	-1.4	-0.4
Neuroticism (2016)	0.2	0.3	0.6	0.1	0.7	0.5	0.8	0.3	0.6
Ulcerative Colitis	0.2	0.2	0.6	0.4	0.7	-0.1	0.8	-0.3	-0.1
Lung FVC	0.2	0.9	2.4	-0.9	-0.5	1.5	-0.2	-1.2	0.5
Tanning	0.2	3.0	7.0	-1.4	-2.6	1.6	-1.8	1.1	1.4
Number of treatments/medications taken	0.2	0.4	1.5	0.2	0.3	0.4	0.7	-1.2	0.2
Diabetes (father)	0.2	0.3	0.7	-0.5	-0.8	-0.7	-0.3	-0.5	0.2
Age when periods started (menarche)	0.2	0.5	2.1	0.8	1.5	0.6	-0.4	-0.1	-0.3
Heart attack	0.2	0.2	0.4	-0.7	-0.1	-0.4	-0.5	0.4	0.4
Fluid intelligence score	0.2	0.5	1.8	0.5	0.7	1.3	-0.0	0.4	-0.0
Father’s age at death	0.2	0.3	0.5	-0.2	-0.7	0.6	-0.5	0.5	0.4
Worrier / anxious feelings	0.2	0.4	1.2	-0.6	0.6	-1.1	0.4	0.3	0.5
Pulse rate	0.2	0.4	1.1	-0.1	-0.5	0.9	-0.4	-1.0	0.3
Headache pain in last month	0.2	0.4	0.9	0.5	0.6	0.9	0.5	-0.4	-0.6
Number of full brothers	0.2	0.2	0.9	0.0	0.1	0.1	0.7	-1.0	-0.2
Worry too long after embarrassment	0.2	0.3	0.9	-0.3	-0.5	-1.0	0.4	-0.6	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.1	-0.3	0.1	0.1	0.1	1.1	-0.1
Medication: Seretide 50 evohaler	0.2	0.3	0.9	-0.9	-0.6	-0.3	0.3	0.0	0.2
Mean time to correctly identify matches	0.2	0.4	1.7	-0.0	0.3	0.4	-0.2	-1.3	-0.7
Pulse rate, automated reading	0.2	0.6	1.6	-0.3	-0.3	1.1	-1.3	-0.1	0.9
Smoking status: Previous	0.2	0.3	1.0	0.5	1.0	-0.6	0.6	0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.1	0.5	-0.1	0.8	0.7	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.5	0.4	-0.7	-0.1	0.3	0.0
Basal metabolic rate	0.2	1.0	3.9	1.1	2.0	0.1	0.8	-0.2	-0.4
Risk taking	0.2	0.3	1.4	-0.2	-1.2	-0.4	0.4	-0.6	-0.0
Impedance of whole body	0.2	0.9	1.7	-1.0	-1.3	-0.7	-0.6	0.7	1.1
Arm predicted mass (left)	0.2	1.2	5.1	1.0	2.3	0.2	0.8	0.2	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.3	0.3	-0.7	0.3	0.2	0.2
Mean Putamen Volume	0.1	0.2	0.4	0.1	0.2	0.3	-0.7	-0.2	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.5	0.3	-0.1	-0.2	0.7	-0.1	-0.1
Waist Hip Ratio (WHR)	0.1	0.3	1.1	1.0	0.6	0.6	0.1	0.2	-0.5
Leg fat-free mass (left)	0.1	0.6	2.4	0.8	1.6	-0.3	0.5	0.0	-0.4
Average weekly fortified wine intake	0.1	0.1	0.3	0.0	-0.6	-0.0	-0.2	-0.5	0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.4	0.1	0.5	-0.2	0.6	-0.1
Impedance of leg (left)	0.1	0.4	0.9	-0.8	-0.6	0.2	-0.6	0.3	0.9
Leg predicted mass (left)	0.1	0.6	2.6	0.8	1.6	-0.2	0.5	-0.0	-0.4
Weight	0.1	0.4	0.8	-0.4	0.2	0.6	-0.9	-0.8	0.5
Noisy workplace	0.1	0.2	0.4	0.6	-0.2	-0.5	0.6	-0.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.3	0.2	0.7	-0.1	-0.6	-0.1
Leg fat-free mass (right)	0.1	0.5	2.1	0.6	1.5	-0.5	0.4	0.1	-0.3
Leg predicted mass (right)	0.1	0.5	1.9	0.6	1.4	-0.5	0.4	0.1	-0.2
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.0	0.8	-0.1	-0.2	-0.7	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	-0.6	0.0	-0.3	-0.6	0.2	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.7	2.2	-1.5	-1.0	-0.4	-0.3	-0.4	0.6
Impedance of leg (right)	0.0	0.1	0.4	-0.2	-0.2	0.7	-0.1	0.2	0.4
Prospective memory result	0.0	0.0	0.1	-0.3	0.2	-0.0	0.1	-0.0	-0.3

Hub : Genes

TUBGCP6

Models

Trait associations