Hub : Genes

ZBED4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.1660	0.0690	6.3e-03	0.148	NA	0.134	NA	0.172	1.3e-04	NA	2.6e-04	NA	3.6e-05
2	GTEx	Brain Cerebellum	0.2990	0.1080	3.1e-04	0.071	NA	0.078	NA	0.107	4.0e-03	NA	2.6e-03	NA	4.6e-04
3	GTEx	Whole Blood	0.0970	0.0410	2.1e-03	0.019	NA	0.009	NA	0.029	7.1e-03	NA	4.8e-02	NA	1.0e-03
4	YFS	Blood	0.0361	0.0101	4.8e-09	0.033	0.028	0.037	0.033	0.035	5.0e-11	1.1e-09	4.4e-12	5e-11	1.2e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.2	2.2	-0.6	0.3	1.5	1.5
Bipolar Disorder or Schizophrenia	5.6	13.8	21.2	-3.6	-3.1	3.4	4.6
Depressed Affect (Nagel 2018)	2.6	5.4	8.4	-2.6	-1.8	1.8	2.9
Depression (Nagel 2018)	1.1	1.6	3.8	-0.8	0.2	1.4	1.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	-0.6	0.2	1.1	0.6
Neuroticism (Nagel 2018)	4.0	9.4	13.6	-3.4	-2.5	2.5	3.7
Schizophrenia (2018)	8.0	16.7	22.1	-4.2	-4.2	3.1	4.7
Schizophrenia vs Biploar Disorder	1.1	1.5	3.2	-1.2	-1.8	0.5	0.9
Worry (Nagel 2018)	4.1	8.6	9.6	-3.1	-2.6	2.9	3.1
Alzheimer’s Disease (in mother)	2.0	2.3	5.0	-1.3	-0.9	1.3	2.2
Alzheimer’s Disease (in father)	0.5	0.5	1.7	-0.3	0.3	-0.6	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	-0.9	-0.3	0.3	1.2
Crohns Disease (2017)	5.4	11.9	15.3	-3.5	-2.7	3.6	3.9
Irritable Bowel Disease (IBD)	3.6	8.5	11.7	-2.7	-2.0	3.4	3.3
Ulcerative Colitis (UC)	0.5	1.0	2.7	-0.5	-0.1	1.6	1.0
Major Depression (MDD)	0.2	0.2	0.6	-0.1	-0.1	0.5	0.8
Reaction Time	0.8	1.6	3.5	-1.1	-1.9	1.3	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.5	-0.6	0.7	0.6	0.4
Breast Cancer	0.4	0.9	1.6	-0.8	-1.1	1.3	-0.4
Ovarian Cancer	1.9	2.6	4.4	1.6	2.1	-1.5	-1.0
Prostate Cancer	0.1	0.2	0.6	0.1	0.8	0.2	0.3
Age at First Birth	1.5	2.1	3.3	-1.8	-1.6	0.9	1.4
Bipolar Disorder (2011)	1.5	1.5	2.8	-1.2	-0.7	1.1	1.7
Body Mass Index (BMI) (2010)	0.9	1.3	3.0	0.9	-0.2	-1.7	-1.2
Coronary Artery Disease (CAD)	0.9	1.1	2.6	-0.7	-0.5	1.6	0.9
Crohns Disease (2012)	5.3	8.5	10.9	-3.1	-2.5	2.7	3.3
Mean Putamen Volume	0.5	0.6	1.3	-1.2	-0.9	0.1	0.3
Fasting Glucose	0.9	1.1	2.4	0.5	1.2	-1.6	-0.1
HbA1C	0.2	0.2	0.4	-0.6	0.1	0.6	0.1
HDL Cholesterol	0.1	0.2	0.7	0.3	0.2	0.9	-0.1
LDL Cholesterol	0.1	0.1	0.1	-0.4	-0.4	-0.0	0.2
Lupus	0.2	0.2	0.5	0.7	0.1	-0.4	-0.5
Neuroticism (2016)	1.1	1.6	2.3	-1.2	-1.5	0.6	1.5
Primary Biliary Cirrhosis	0.2	0.3	1.0	0.0	0.1	1.0	0.6
Rheumatoid Arthritis	1.8	2.5	4.4	1.6	2.1	-1.3	-1.1
Schizophrenia (2014)	6.3	14.0	17.7	-4.0	-3.5	3.2	4.2
Triglycerides	0.1	0.1	0.4	0.0	-0.2	-0.6	-0.3
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.2	1.1	0.3	-1.8	-1.1
Ulcerative Colitis	1.0	1.5	2.0	-1.4	-1.1	1.0	1.3
Blood Eosinophil Count	0.1	0.6	1.8	-0.2	-0.1	-0.7	-1.3
Blood Platelet Count	9.8	113.2	146.4	-12.1	-11.4	9.1	9.7
Blood Red Count	0.2	1.9	6.7	-0.1	0.1	-1.0	-2.6
Blood White Count	0.2	1.5	5.2	-0.2	-0.9	-0.4	-2.3
Heel T-Score	4.6	36.2	50.3	5.6	4.1	-6.8	-7.1
BMI	0.1	0.7	1.6	-1.0	-1.3	-0.5	0.3
Height	1.1	21.2	28.3	-4.5	-3.9	5.3	4.6
Waist Hip Ratio (WHR)	0.3	1.6	2.6	1.4	1.6	0.1	-1.3
Systolic Blood Pressure	2.6	13.1	15.7	3.7	4.0	-2.7	-3.9
Smoking Status	0.0	0.1	0.2	-0.1	0.5	0.2	-0.0
Allergy or Eczema	1.5	3.9	4.5	1.9	2.1	-2.1	-1.8
Cardiovascular Disease	0.0	0.1	0.2	0.0	0.3	-0.5	0.0
Hypothyroidism (self reported)	0.3	0.6	1.3	0.2	0.2	1.1	-1.0
Respiratory disease	0.1	0.2	0.5	-0.7	-0.5	-0.3	0.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	0.3	0.4	-0.8	-1.3
Lung FEV1/FVC ratio	0.6	3.0	3.6	1.8	1.6	-1.6	-1.9
Lung FVC	0.1	0.4	1.0	0.7	1.0	-0.1	-0.5
Neuroticism	6.2	15.0	19.7	-4.4	-3.7	3.4	3.9
Chronotype (morning person)	1.3	3.0	4.1	-1.6	-1.6	2.0	1.6
Hair Pigment	0.2	5.3	7.6	-2.6	-1.8	1.9	2.8
Tanning	0.9	10.9	15.6	4.0	3.5	-1.8	-3.6
Hand grip strength (left)	1.2	3.2	4.2	-2.0	-1.7	1.3	2.1
Number of treatments/medications taken	0.2	0.4	1.4	-0.4	0.2	1.2	0.5
Average weekly spirits intake	0.5	0.6	0.9	-1.0	-0.8	0.6	0.6
Sensitivity / hurt feelings	0.6	1.1	1.9	-1.0	-1.4	0.1	1.1
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.9	-1.2	-1.1	1.5	2.4
Hearing difficulty/problems: Yes	2.9	4.5	6.2	-2.5	-2.2	1.3	2.3
Relative age of first facial hair	0.5	1.0	2.5	-0.9	0.1	1.6	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.0	0.6	0.7	-0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.8	-1.1	-1.7	0.4	0.7
Ever had hysterectomy (womb removed)	1.2	1.4	4.4	-0.2	-0.8	-0.8	-2.1
Systolic blood pressure, automated reading	1.3	3.8	6.7	2.0	1.9	-1.1	-2.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	-1.1	-0.7	0.6	0.1
Angina	0.5	0.7	1.7	-1.3	-0.7	0.7	0.2
Medication for hormone replacement therapy	0.0	0.0	0.0	0.2	0.1	0.2	0.1
Vitamin and mineral supplements	0.9	1.2	2.6	-1.3	-1.6	0.5	0.5
Supplements: Zinc	0.7	0.7	1.7	-0.8	-0.1	1.3	0.7
Medication: Co-codamol	3.2	3.7	4.5	2.0	1.9	-1.6	-2.1
Medication: Metformin	0.4	0.5	1.1	0.1	-0.2	-1.0	-1.1
Diabetes (father)	2.9	3.6	5.4	1.8	1.6	-2.3	-1.8
Diabetes (mother)	0.5	0.6	0.9	0.7	0.4	-1.0	-0.9
Severe depression (siblings)	4.5	5.0	5.4	-2.1	-2.2	2.3	2.3
Pack years adult smoking proportion	0.9	1.3	1.7	1.3	1.2	-1.1	-0.9
Impedance of leg (right)	0.4	2.0	3.9	2.0	1.4	-1.0	-1.0
Leg fat-free mass (left)	0.8	4.1	6.2	-2.5	-2.0	2.0	1.5
Trunk fat percentage	0.0	0.1	0.4	0.2	-0.0	-0.6	-0.3
Hand grip strength (right)	0.6	1.6	3.4	-1.2	-0.9	0.9	1.8
Townsend deprivation index at recruitment	2.1	3.0	4.4	-1.9	-1.4	1.4	2.1
Current tobacco smoking	0.4	0.7	1.0	0.6	1.0	-0.8	-0.8
Average weekly fortified wine intake	0.1	0.1	0.2	0.3	0.2	-0.5	-0.4
Maternal smoking around birth	0.7	1.0	1.5	1.2	1.0	-0.2	-1.2
Fed-up feelings	1.5	2.7	4.8	-1.6	-1.0	1.5	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.7	-0.8	-0.5	0.5	1.6
Relative age voice broke	0.2	0.3	1.2	0.1	0.3	1.1	-0.0
Taking other prescription medications	0.9	1.3	1.9	-1.3	-1.1	1.4	0.7
Age when periods started (menarche)	0.2	0.4	0.8	0.4	0.8	0.9	-0.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.8	-0.7	-0.3	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (left)	4.8	11.0	15.4	3.0	2.3	-3.9	-3.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.1	-0.0	-0.9	0.7
Qualifications: CSEs or equivalent	0.9	1.2	1.9	0.7	1.3	-1.4	-0.9
Serious illness, injury or assault to yourself	0.4	0.5	0.8	0.6	0.3	-0.9	-0.9
High blood pressure	0.1	0.1	0.4	-0.3	-0.2	0.6	0.2
Hayfever, allergic rhinitis or eczema	2.5	5.4	6.6	2.3	2.6	-2.2	-2.2
Multivitamins +/- minerals	0.1	0.1	0.3	-0.3	-0.3	-0.5	-0.3
Stomach or abdominal pain in last month	0.5	0.6	1.3	-1.1	-0.5	-0.1	0.9
Supplements: Glucosamine	0.6	0.8	2.1	0.7	0.2	-1.5	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	-0.6	-0.6	0.2	1.4
Medication: Atenolol	0.0	0.0	0.0	0.2	0.2	-0.1	-0.2
Medication: Levothyroxine sodium	0.4	0.7	1.3	0.3	0.7	1.0	-1.1
Sitting height	0.7	4.8	11.0	-2.1	-1.0	3.3	1.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.7	0.6	-0.2	-0.3
High blood pressure (mother)	0.7	1.0	2.1	0.2	1.1	1.5	-0.8
Body mass index (BMI)	0.1	0.2	0.5	-0.3	-0.4	-0.7	-0.5
Impedance of leg (left)	0.5	2.4	4.3	2.1	1.6	-1.3	-1.0
Leg predicted mass (left)	0.8	4.2	6.3	-2.5	-2.0	2.0	1.6
Trunk fat mass	0.0	0.1	0.3	-0.5	-0.5	0.2	0.1
Waist circumference	0.1	0.2	0.3	-0.5	-0.5	0.5	-0.3
Number of incorrect matches in round	0.3	0.4	0.9	-0.7	-0.4	0.9	0.5
Past tobacco smoking	1.8	3.2	5.9	1.1	0.5	-2.4	-2.3
Alcohol usually taken with meals	0.6	1.0	2.1	1.0	0.5	-0.8	-1.5
Nervous feelings	1.2	2.3	2.9	-1.7	-1.2	1.5	1.6
Frequency of tenseness / restlessness in last 2 weeks	5.5	8.6	13.0	-2.6	-2.4	3.0	3.6
Hearing difficulty/problems with background noise	3.0	4.8	8.1	-2.2	-2.1	1.3	2.8
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	-0.5	-0.1	0.5	0.6
Had menopause	0.4	0.4	0.7	-0.8	-0.7	0.8	-0.0
Had other major operations	0.4	0.5	1.4	-0.4	-0.2	0.5	1.2
Forced vital capacity (FVC)	0.0	0.1	0.1	-0.4	-0.3	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	8.3	19.1	28.7	3.6	2.9	-5.4	-5.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	3.1	-1.6	-1.7	1.3	1.3
Qualifications: None of the above	0.9	2.0	2.9	1.7	1.4	-1.6	-0.7
Financial difficulties in last 2 years	3.3	4.4	6.4	-2.5	-2.5	0.2	2.2
Mouth/teeth dental problems	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.1
Heart attack	0.1	0.1	0.3	-0.2	0.2	-0.1	0.6
Allergy	0.4	0.9	1.9	-0.8	-1.4	0.9	0.7
Pain all over the body in last month	1.0	1.1	2.1	-1.4	-1.4	0.5	0.2
Diabetes (self-reported)	0.3	0.5	1.4	-0.6	-0.3	1.2	0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.2	0.5	1.0	-0.5	-1.1
Medication: Ramipril	1.0	1.3	2.9	1.1	0.4	-1.0	-1.7
Medication: Simvastatin	0.6	0.9	2.6	0.2	1.0	1.6	0.1
Fluid intelligence score	0.4	0.9	2.2	0.6	1.5	-0.6	-0.7
Illnesses of siblings	0.2	0.3	1.3	-0.2	0.2	-1.2	-0.0
Neuroticism score	5.1	10.7	14.0	-3.5	-2.9	2.9	3.7
Weight	0.4	1.8	2.9	-1.7	-1.5	1.2	0.7
Impedance of arm (right)	0.2	1.1	1.6	1.3	0.9	-1.2	-0.8
Arm fat percentage (right)	0.2	0.9	2.3	0.6	0.3	-1.5	-1.1
Trunk fat-free mass	0.8	4.5	7.5	-2.3	-1.8	2.7	1.3
Hip circumference	0.5	2.1	3.8	-1.9	-1.9	0.9	0.7
Time employed in main current job	0.4	0.5	1.4	-0.1	0.7	1.2	-0.3
Alcohol intake versus 10 years previously	3.3	5.0	7.0	2.1	2.1	-2.0	-2.7
Father’s age at death	0.3	0.4	1.0	0.2	-0.0	0.8	-1.0
Worrier / anxious feelings	2.2	4.1	5.4	-2.3	-2.3	1.7	1.7
Frequency of tiredness / lethargy in last 2 weeks	4.1	6.7	8.5	-2.9	-2.5	2.1	2.7
Falls in the last year	3.9	5.3	6.8	-2.5	-2.1	2.6	1.9
Hair/balding pattern: Pattern 3	0.6	0.8	1.2	1.1	1.0	-0.2	-1.0
Number of live births	0.2	0.3	0.6	-0.1	-0.7	0.0	-0.8
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	0.2	0.3	-0.5	-0.3
Pulse rate	2.0	3.4	4.5	1.8	2.1	-1.7	-1.7
Happiness	0.4	0.5	1.1	-0.8	-0.4	-0.0	1.0
Noisy workplace	2.3	2.8	4.9	2.0	2.2	-1.0	-1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	-0.4	0.8	-0.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.9	-0.4	-0.4	0.8	1.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.9	0.4	0.9	0.5	-0.1
Asthma	0.4	0.7	1.5	-1.0	-1.2	-0.2	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.6	0.6	0.8	-0.6	-0.8
Medication: Cholesterol lowering	0.8	1.2	2.7	-0.8	-0.1	1.6	1.3
Depression (self-reported)	3.3	3.9	5.2	-2.3	-2.2	1.6	1.8
Medication: Lansoprazole	0.7	0.8	2.3	-0.8	-0.3	1.5	-0.4
Prospective memory result	2.4	2.9	3.7	-1.8	-1.9	1.7	1.4
Lung cancer (father)	5.2	6.0	6.9	-2.3	-2.3	2.6	2.6
Illnesses of mother	0.7	0.8	2.2	-0.4	-1.0	-1.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.1	0.1	0.2	0.0	0.2
Pulse wave Arterial Stiffness index	3.2	3.7	5.2	-1.8	-1.2	2.2	2.3
Impedance of arm (left)	0.2	1.0	1.5	1.2	0.9	-1.2	-0.7
Arm fat mass (right)	0.1	0.2	0.3	-0.3	-0.4	-0.6	-0.6
Trunk predicted mass	0.8	4.6	7.8	-2.3	-1.8	2.8	1.4
Standing height	1.0	9.7	16.6	-3.1	-2.5	4.1	2.5
Length of working week for main job	0.1	0.1	0.2	-0.1	0.2	0.4	0.5
Exposure to tobacco smoke at home	1.3	1.4	3.3	-0.9	-0.7	1.8	1.0
Breastfed as a baby	0.7	0.9	1.7	0.6	1.0	-0.8	-1.3
Tense / ‘highly strung’	2.9	4.7	6.7	-2.0	-1.7	2.6	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.5	-0.9	0.7	0.4
Hair/balding pattern: Pattern 4	1.0	2.5	4.3	2.1	1.9	-1.2	-0.9
Birth weight of first child	0.2	0.4	1.2	-1.1	-0.7	0.0	0.2
Peak expiratory flow (PEF)	2.7	6.3	9.6	-3.1	-2.5	2.1	2.3
Pulse wave reflection index	5.2	6.5	8.1	-2.4	-2.1	2.9	2.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.6	-0.4	-0.1	0.7
Loud music exposure frequency	0.2	0.2	0.5	-0.7	-0.3	-0.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-1.1	-0.8	-0.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.3
Blood clot in the leg (DVT)	1.1	1.4	2.7	1.3	1.6	-1.0	-0.7
Medication: Paracetamol	1.2	2.0	4.8	1.2	1.3	-2.2	-0.3
Headache pain in last month	0.2	0.4	0.7	0.1	0.2	-0.8	-0.9
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.0	0.1	-0.7	-1.7	-0.4
Glaucoma (self-reported)	2.5	2.9	3.9	-1.8	-1.7	1.3	2.0
Gout (self-reported)	0.2	0.3	0.6	-0.2	0.5	0.8	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.3	0.2	0.5	1.1	-1.1
Medication: Amlodipine	1.5	2.0	3.0	-1.3	-1.3	1.3	1.7
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.1	0.1	-0.3	0.0
Birth weight	2.0	4.3	7.8	-2.8	-2.1	1.3	1.8
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.4	-0.6	0.3	1.9	1.1
High blood pressure (siblings)	1.3	1.8	2.7	-1.3	-1.7	1.6	0.6
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.3	-0.0	0.4	0.5
Body fat percentage	0.1	0.6	1.3	0.6	0.3	-1.1	-0.8
Leg fat percentage (right)	0.3	1.1	2.0	0.7	0.3	-1.2	-1.4
Arm fat-free mass (right)	0.8	4.3	5.6	-2.4	-2.0	2.4	1.5
Exposure to tobacco smoke outside home	0.0	0.0	0.1	-0.2	-0.4	-0.1	-0.0
Comparative body size at age 10	0.6	1.7	2.5	1.2	0.6	-1.6	-1.6
Number of full brothers	0.1	0.1	0.4	-0.7	-0.1	0.0	-0.1
Worry too long after embarrassment	0.1	0.1	0.4	-0.1	-0.2	-0.7	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.5	-1.2	-1.0	0.9	0.9
Wheeze or whistling in the chest in last year	1.0	1.8	2.3	-1.5	-1.3	1.1	1.4
Number of children fathered	2.2	2.5	3.9	-1.4	-1.5	1.3	2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	1.6	-1.2	-1.3	1.2	1.3
Age at first live birth	0.3	0.5	0.8	-0.8	-0.2	0.9	0.8
Pulse wave peak to peak time	2.7	3.2	5.1	1.7	1.1	-1.9	-2.2
Health satisfaction	0.2	0.3	0.5	-0.5	-0.4	-0.7	0.5
Shortness of breath walking on level ground	0.5	0.6	1.6	-0.1	0.2	1.3	0.8
Qualifications: College or University degree	0.2	0.7	1.5	0.3	0.9	-0.6	-1.2
Eye problems/disorders: None of the above	0.9	1.1	2.1	1.5	1.2	-0.0	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.4	0.3	-0.0	-1.2	0.2
Emphysema/chronic bronchitis	0.8	0.9	1.4	-0.8	-0.7	1.2	1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	0.5	-0.7	-0.7	0.7	0.7
Neck or shoulder pain in last month	0.3	0.4	1.0	-0.1	-0.1	0.7	1.0
Medication: Blood pressure	0.4	0.8	2.5	-0.2	0.3	1.6	0.7
Angina (self-reported)	0.4	0.5	1.3	-1.1	-0.5	0.7	0.1
Migraine (self-reported)	0.9	1.2	1.8	1.0	1.3	-0.3	-1.4
Medication: Ibuprofen	0.3	0.3	0.5	0.2	0.5	-0.7	-0.7
Medication: Allopurinol	0.7	0.9	2.4	0.9	1.6	-0.1	-0.5
Medication: Omeprazole	2.0	2.4	4.2	-1.4	-1.4	1.3	2.1
Medication: Seretide 50 evohaler	0.6	0.7	1.2	-1.1	-1.1	-0.1	0.8
Mean time to correctly identify matches	2.1	3.9	6.4	-1.9	-2.5	2.1	1.0
Heart disease (mother)	1.1	1.4	4.0	-0.3	-0.1	2.0	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	9.0	1.7	1.3	-3.0	-1.8
Whole body fat mass	0.0	0.2	0.5	-0.5	-0.7	0.0	0.0
Leg fat mass (right)	0.1	0.2	0.5	-0.5	-0.7	-0.3	-0.4
Arm predicted mass (right)	1.1	5.5	7.8	-2.6	-2.2	2.8	1.6
Pulse rate, automated reading	1.8	5.8	7.5	2.4	2.7	-2.0	-2.5
Alcohol intake frequency.	0.1	0.2	0.5	-0.3	-0.0	0.5	0.7
Comparative height size at age 10	3.1	16.9	19.3	-4.4	-4.3	4.0	3.7
Number of full sisters	1.1	1.4	2.0	1.4	1.4	-0.7	-1.0
Suffer from ‘nerves’	2.3	3.7	4.7	-2.1	-1.9	1.5	2.2
Overall health rating	0.9	1.8	2.5	-1.5	-1.5	0.5	1.6
Chest pain or discomfort	7.1	10.2	12.7	-3.6	-2.8	3.1	3.3
Had major operations	0.1	0.1	0.2	0.2	0.4	-0.3	0.0
Age at last live birth	0.8	1.2	2.3	-1.0	-0.4	1.5	1.1
Family relationship satisfaction	2.0	2.4	3.7	-1.8	-1.3	1.1	1.9
Leg pain on walking	0.5	0.6	1.3	1.0	0.5	-0.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	-0.7	-0.6	0.3	0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.1	-0.1	0.2	0.1	1.0
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.3	0.3	-0.2	0.1
Medication: Aspirin	0.4	0.6	1.5	-0.7	-0.4	1.2	0.0
Supplements: Vitamin C	1.3	1.5	2.3	1.5	1.3	-1.1	-1.1
Knee pain experienced in last month	0.2	0.3	0.9	-0.3	-0.9	0.5	0.2
Hypertension (Self-reported)	0.0	0.1	0.1	-0.1	-0.1	0.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.7	0.3	0.7	-0.5
Illnesses of father: Heart disease	3.3	4.6	5.2	-1.9	-2.3	2.1	2.2
Illnesses of siblings: Diabetes	0.3	0.4	1.1	-0.6	0.3	0.3	1.0
Smoking status: Previous	0.7	1.1	2.1	-0.4	-0.2	1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	-0.3	-0.0	-0.1	0.4
Whole body fat-free mass	0.8	4.8	6.6	-2.5	-2.0	2.6	1.5
Leg fat-free mass (right)	0.8	4.3	6.6	-2.6	-2.0	1.9	1.7
Arm fat percentage (left)	0.2	1.0	2.3	0.5	0.2	-1.5	-1.1
Average weekly red wine intake	0.7	1.0	2.2	-1.2	-1.5	0.5	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.4	-0.3	0.1	-0.3
Mood swings	1.7	3.1	6.1	-1.8	-1.3	1.2	2.5
Loneliness, isolation	1.3	1.8	2.0	-1.2	-1.3	1.4	1.4
Long-standing illness, disability or infirmity	0.2	0.3	0.4	-0.6	-0.6	0.5	0.1
Ever had bowel cancer screening	0.3	0.3	1.0	0.4	1.0	-0.4	-0.1
Diabetes diagnosed by doctor	0.2	0.4	0.8	0.4	0.6	-0.3	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.5	6.0	1.8	2.5	-1.7	-1.4
Friendships satisfaction	1.1	1.4	2.1	-1.5	-1.4	1.0	0.6
Qualifications: nursing, teaching	1.5	2.3	4.5	-1.7	-2.1	1.3	-0.4
Commuting to job workplace: Walk	0.3	0.4	0.8	-0.5	-0.9	-0.1	0.6
Eye problems/disorders: Cataract	1.8	2.1	4.4	1.4	0.8	-2.1	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.2	-1.3	-1.1	1.5	0.7
Medication for cholesterol	0.3	0.5	1.3	-0.6	-0.4	-0.2	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.9	1.3	0.6	-1.7	-0.8
Back pain experienced in last month	1.1	1.6	2.4	-1.5	-1.3	1.5	0.5
Mineral and other dietary supplements	0.4	0.5	1.9	-0.1	-0.3	0.4	1.4
Breast cancer (self-reported)	1.0	1.2	3.4	-0.2	0.2	1.1	1.9
Asthma (self-reported)	0.2	0.4	0.7	-0.7	-0.8	-0.3	0.6
Osteoporosis (self-reported)	1.2	1.5	2.4	-1.0	-0.5	1.6	1.5
Osteoarthritis (self-reported)	2.0	2.6	5.8	1.5	1.3	-0.7	-2.4
Medication: Aspirin	0.4	0.5	1.5	-0.6	-0.3	1.2	-0.1
Medication: Gliclazide	0.2	0.2	0.9	-0.1	-0.1	-0.9	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.2	0.6	-0.1	-0.1
Smoking status: Current	0.6	1.0	1.8	0.8	1.3	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	-0.1	-0.2	0.2	0.2
Whole body water mass	0.9	4.9	6.5	-2.5	-2.1	2.5	1.6
Leg predicted mass (right)	0.8	4.1	6.4	-2.5	-2.0	1.8	1.6
Arm fat mass (left)	0.1	0.2	0.3	-0.5	-0.6	-0.4	-0.3
Number of self-reported non-cancer illnesses	1.6	2.8	5.0	-1.8	-1.1	2.2	1.3
Average weekly champagne plus white wine intake	0.1	0.2	0.5	0.3	-0.7	-0.4	-0.1
Miserableness	1.4	2.5	6.4	-1.5	-0.5	1.1	2.5
Guilty feelings	6.6	9.9	12.6	-3.5	-3.2	2.3	3.3
Wears glasses or contact lenses	3.1	3.6	4.4	-2.1	-1.8	2.1	1.5
Ever taken oral contraceptive pill	1.1	1.2	1.4	1.2	1.0	-1.1	-1.0
Hearing aid user	2.5	2.9	5.5	1.5	2.4	-1.7	-0.9
Mother’s age at death	0.7	0.9	1.6	0.8	0.8	-0.9	-1.2
Financial situation satisfaction	0.1	0.1	0.1	0.2	0.3	-0.3	0.2
Tinnitus: Yes, now most or all of the time	4.8	5.7	8.4	-2.9	-2.9	1.5	2.0
Commuting to job workplace: Public transport	1.3	1.5	2.2	-1.4	-1.0	1.5	1.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.0	-1.0	-0.9	0.4	0.9
Medication: Blood pressure	0.3	0.6	1.3	-0.9	-1.1	0.6	-0.0
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.6	0.8	0.5	-1.9	-0.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.2	0.8	0.9	-0.8	-1.8
High cholesterol (Self-reported)	0.3	0.6	1.7	0.6	1.3	-0.4	-0.4
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.1	-0.3	0.4	-0.4
Medication: Paracetamol	0.8	1.3	2.4	1.0	1.3	-1.6	-0.5
Medication: Lisinopril	0.3	0.4	1.1	-0.1	0.6	1.1	-0.5
Medication: Atorvastatin	0.4	0.5	1.2	-0.8	-0.4	0.1	1.1
Illnesses of father: High blood pressure	0.2	0.3	0.4	-0.4	-0.6	-0.3	0.6
Alcohol drinker status: Never	0.2	0.2	0.5	0.1	0.3	-0.7	-0.5
Ever smoked	3.6	6.4	9.1	-2.1	-1.8	3.0	3.0
Basal metabolic rate	0.7	3.7	5.1	-2.2	-1.8	2.2	1.3
Leg fat percentage (left)	0.3	1.2	2.1	0.8	0.4	-1.4	-1.5
Arm fat-free mass (left)	1.0	5.2	6.9	-2.6	-2.2	2.6	1.6
Number of operations (self-reported)	1.0	1.4	1.9	-1.3	-0.7	1.3	1.4
Average weekly beer plus cider intake	0.3	0.4	1.6	0.2	0.3	1.2	-0.0
Irritability	3.4	5.8	8.2	-2.4	-1.6	2.5	2.9
Risk taking	0.1	0.1	0.2	0.2	0.4	-0.3	-0.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.5	-1.0	-0.7	1.6	1.0
Fractured/broken bones in last 5 years	3.0	3.9	8.1	-1.7	-1.0	1.9	2.8
Age started oral contraceptive pill	1.7	2.1	3.6	-1.8	-1.9	1.1	0.7
Diastolic blood pressure, automated reading	1.0	3.0	3.9	1.6	1.8	-1.4	-2.0
Ever depressed for a whole week	1.3	1.6	2.3	-1.4	-1.5	1.4	0.6
Unable to work because of sickness or disability	0.7	0.9	1.8	-0.9	-0.9	0.2	1.4
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.1	0.0	-0.5	-0.7
Myopia	1.1	1.5	3.3	-1.1	-0.7	1.8	1.1
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.3	0.1	-0.6	-0.4
Cholesterol lowering medication	1.0	1.5	3.2	1.3	1.8	-0.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	4.8	-1.3	-1.3	1.1	2.2
Pain experienced in last month	1.8	3.0	5.6	2.4	1.9	-1.2	-1.1
Supplements: Calcium	0.9	1.0	2.7	-0.6	-0.3	1.6	1.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.0	-0.4	-0.0	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	-0.4	-0.0	0.1	0.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.4	1.3	1.5	-1.0	-0.5
Heart disease (siblings)	0.3	0.3	0.6	0.3	0.5	0.7	-0.7
Alcohol drinker status: Previous	2.1	2.4	3.7	-1.7	-1.4	1.1	1.9
Pack years of smoking	1.1	1.7	2.6	1.5	1.6	-1.0	-0.8
Impedance of whole body	0.2	1.2	2.1	1.5	1.2	-0.9	-0.6
Leg fat mass (left)	0.1	0.3	0.6	-0.5	-0.7	-0.4	-0.3
Arm predicted mass (left)	1.0	5.2	7.0	-2.6	-2.2	2.6	1.5