TWAS hub - TRABD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.067	0.026	0.0031	0.002	0.007	0.014	0.009	0.009	0.1500	0.0400	0.0065	0.026	0.02300
2	GTEx	Adipose Subcutaneous	0.106	0.048	0.0059	0.022	NA	0.005	NA	0.034	0.0057	NA	0.1100	NA	0.00082
3	GTEx	Brain Cerebellum	0.323	0.109	0.0014	0.015	NA	0.049	NA	0.066	0.1200	NA	0.0140	NA	0.00530
4	GTEx	Liver	0.217	0.075	0.0010	0.015	NA	0.051	NA	0.031	0.1200	NA	0.0150	NA	0.04800
5	GTEx	Pancreas	0.222	0.082	0.0069	-0.005	NA	0.004	NA	0.010	0.6200	NA	0.2000	NA	0.12000
6	TCGA	Soft Tissue Sarcoma	0.095	0.047	0.0022	0.011	0.014	-0.005	NA	0.006	0.0700	0.0450	0.8200	NA	0.13000
7	TCGA	Thyroid Carcinoma	0.035	0.022	0.0095	0.039	0.023	0.019	NA	0.030	0.0001	0.0024	0.0053	NA	0.00055

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Platelet Count	6.6	76.6	272.2	-3.8	-6.2	16.5	-6.8	-6.9	-2.6	10.5
Medication: Metformin	4.7	6.7	14.8	0.1	3.8	-3.2	1.6	3.9	2.3	-0.3
Number of operations (self-reported)	3.4	5.1	19.7	0.1	-4.4	1.7	-2.4	-1.7	-1.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.2	12.7	1.3	3.3	-2.0	3.6	1.4	3.5	0.8
Fractured/broken bones in last 5 years	2.9	3.8	15.5	-1.9	-1.5	0.5	-2.0	-3.9	-0.6	0.8
Type 2 Diabetes (T2D) (2018)	2.8	5.2	12.1	1.2	2.4	-2.1	2.3	3.5	2.5	-0.8
Qualifications: nursing, teaching	2.7	4.1	7.6	2.0	2.5	-1.6	2.8	2.2	2.0	-0.1
Supplements: Vitamin C	2.6	3.1	9.9	1.1	1.1	0.9	2.1	0.7	3.1	1.9
Illnesses of mother	2.4	2.9	6.4	-1.9	-2.5	0.5	-1.8	-2.3	-0.5	-1.1
Had other major operations	2.3	2.8	11.1	-0.1	-3.3	1.7	-1.3	-1.6	-1.1	-0.4
Friendships satisfaction	2.3	2.9	6.8	2.6	1.5	2.1	1.0	2.1	1.0	0.7
Average weekly beer plus cider intake	2.3	3.3	9.0	-2.3	-1.8	-1.1	-1.9	-3.0	-0.6	0.7
Alzheimer’s Disease (in mother)	2.2	2.6	9.3	1.7	0.4	1.3	1.2	0.3	1.5	3.0
Loneliness, isolation	2.1	2.9	7.0	-2.1	1.9	0.9	-0.0	-1.9	1.0	2.6
Heel T-Score	2.0	15.6	47.7	2.6	2.2	-5.5	1.6	6.9	-1.0	-4.0
Neuroticism	2.0	4.8	26.0	-5.1	-1.4	-0.7	-1.2	-1.6	-0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	10.6	-1.4	-0.5	2.1	-0.6	-1.0	1.8	3.3
Medication: Gliclazide	2.0	2.3	6.3	-0.1	2.5	-2.3	0.6	1.4	0.8	-1.1
Maternal smoking around birth	1.9	2.7	13.5	-0.1	0.4	2.0	-0.2	-0.3	1.1	3.7
Diabetes (self-reported)	1.9	3.0	6.6	0.1	2.6	-2.2	1.1	2.1	2.0	-0.2
Alcohol intake versus 10 years previously	1.9	2.8	4.7	0.9	1.6	1.5	1.9	1.4	2.2	1.9
Exposure to tobacco smoke outside home	1.9	2.5	8.0	-2.8	-1.4	-2.2	-0.7	-0.5	-1.3	-0.5
Diabetes diagnosed by doctor	1.9	3.2	7.1	0.5	2.7	-1.8	1.0	2.5	2.1	0.0
Commuting to job workplace: Public transport	1.9	2.3	5.5	0.5	-1.6	2.3	-2.2	-1.2	-0.1	1.1
Irritability	1.9	3.2	7.8	-2.2	-2.8	1.1	-1.6	-1.4	-1.6	-1.2
Sensitivity / hurt feelings	1.8	3.1	7.1	-1.1	-2.7	-0.5	-1.2	-1.5	-2.3	-1.9
Current tobacco smoking	1.8	2.9	9.8	-1.7	-1.2	1.1	-3.1	-1.1	-1.1	1.7
Chronic bronchitis/emphysema (mother)	1.8	2.1	5.1	0.3	2.1	-0.3	2.3	0.4	2.1	0.6
Shortness of breath walking on level ground	1.8	2.1	7.4	-1.5	0.0	2.7	-0.6	-1.0	-1.2	1.4
Emphysema/chronic bronchitis	1.8	2.0	6.2	-0.3	-2.4	0.6	-0.6	-0.3	-2.5	-1.1
Unable to work because of sickness or disability	1.8	2.3	7.9	-1.9	1.5	1.2	0.3	-0.5	0.8	2.8
Diabetes (mother)	1.7	2.2	8.0	1.2	0.6	-1.5	1.4	2.8	1.0	-0.7
Medication: Lansoprazole	1.7	2.0	8.3	-1.3	-2.9	0.5	-1.1	-1.1	-0.9	0.1
Peak expiratory flow (PEF)	1.7	3.9	7.6	2.0	2.7	-0.7	1.8	2.0	2.8	0.8
Number of full sisters	1.7	2.0	5.7	-0.3	2.4	-1.2	1.7	1.5	1.4	0.4
Neuroticism (Nagel 2018)	1.6	3.8	16.8	-4.1	-0.9	0.4	-1.2	-2.5	-0.9	-0.3
Supplements: Zinc	1.6	1.8	5.3	1.0	0.8	0.2	1.4	1.1	2.3	1.6
Fed-up feelings	1.6	3.0	12.2	-3.5	-0.8	0.4	-1.4	-2.1	-1.2	-0.2
Nervous feelings	1.6	3.0	8.9	-1.8	-3.0	0.3	-1.4	-1.2	-1.8	-1.3
Neuroticism score	1.6	3.3	13.8	-3.7	-1.8	0.2	-0.9	-2.0	-0.6	-0.8
Depressed Affect (Nagel 2018)	1.5	3.1	13.0	-3.6	0.3	0.5	-1.1	-2.6	-0.4	-0.0
Medication for cholesterol	1.5	2.3	7.4	-2.7	-0.4	0.2	-1.1	-2.4	-0.7	0.8
Financial situation satisfaction	1.5	1.9	4.8	-2.2	-1.5	1.8	-1.0	-0.8	-1.0	0.8
Alzheimer’s Disease (including proxy)	1.4	2.0	5.1	2.3	-0.9	1.8	0.1	-0.2	1.0	2.0
Systolic blood pressure, automated reading	1.4	4.2	17.0	2.2	0.5	-1.9	-0.1	4.1	-0.9	-1.6
Medication: Co-codamol	1.4	1.6	4.4	0.7	-1.9	2.1	-0.3	-0.1	-0.7	1.5
Hearing difficulty/problems with background noise	1.4	2.3	6.2	-0.2	2.1	0.2	2.5	0.1	2.3	0.3
Exposure to tobacco smoke at home	1.4	1.6	4.8	-0.7	-2.2	-0.1	-0.6	-1.1	-1.3	-1.6
Medication: Omeprazole	1.4	1.6	5.9	0.9	1.8	0.0	2.4	0.4	1.0	0.7
Heart disease (mother)	1.4	1.7	5.6	0.8	2.1	0.3	2.4	0.5	-0.5	-0.7
Hypertension (Self-reported)	1.4	3.8	10.0	2.9	1.2	-1.8	1.5	3.2	0.9	-0.8
Medication: Lisinopril	1.4	1.8	4.1	1.2	-1.2	-1.9	-0.0	1.3	-0.6	-2.0
Neuroticism (2016)	1.3	1.8	6.8	-1.8	-0.8	0.3	-0.5	-1.1	-2.6	-0.8
Rheumatoid Arthritis	1.3	1.8	4.1	-1.0	-1.0	0.3	-2.0	-1.3	-1.8	-1.2
Smoking Status	1.3	3.2	8.7	-2.9	-1.4	0.5	-2.7	0.6	-1.9	0.8
High blood pressure	1.3	3.7	10.3	2.7	0.9	-1.7	1.6	3.2	1.1	-0.7
Worrier / anxious feelings	1.3	2.4	7.6	-2.7	-1.6	-0.8	-0.8	-1.9	-0.4	-1.2
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	10.3	1.9	0.5	1.7	0.9	3.2	-0.6	0.3
Mean time to correctly identify matches	1.3	2.5	8.9	1.4	3.0	1.2	1.6	1.4	-0.4	0.9
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.9	1.4	1.7	-0.8	2.0	0.6	-0.3	-0.9
Commuting to job workplace: Walk	1.3	1.4	4.3	-1.6	-1.2	0.0	-2.1	-1.0	-0.2	0.9
Smoking status: Current	1.3	2.1	7.5	-1.2	-1.0	1.1	-2.7	-0.4	-1.3	1.3
Medication: Blood pressure	1.3	2.5	7.9	2.4	0.7	-0.8	1.4	2.8	0.8	-0.7
Ever smoked	1.3	2.4	3.8	-1.4	-1.8	1.4	-1.7	-2.0	-0.4	1.6
Vascular/heart problems diagnosed by doctor	1.3	3.5	10.6	-2.8	-1.1	1.3	-1.5	-3.3	-0.9	0.4
Worry (Nagel 2018)	1.2	2.6	11.1	-3.3	-1.7	-0.3	-0.5	-1.5	-0.8	-0.7
Chronotype (morning person)	1.2	2.8	10.9	-0.8	-3.3	0.8	-1.9	-1.4	-1.3	-0.0
Townsend deprivation index at recruitment	1.2	1.6	2.3	-1.5	-1.0	1.5	-1.2	-1.5	-1.4	0.5
Medication: Levothyroxine sodium	1.2	2.0	8.4	0.5	-0.2	2.9	0.1	1.9	-1.0	0.8
Alcohol usually taken with meals	1.2	1.9	4.1	1.7	-1.0	0.3	-0.8	1.8	-1.2	-2.0
Had menopause	1.2	1.5	2.9	1.7	-1.6	1.5	-1.0	0.2	-1.2	0.0
Depression (self-reported)	1.2	1.5	7.0	-0.2	-0.5	2.7	-0.4	-0.7	0.4	1.4
Length of working week for main job	1.2	1.3	2.7	1.2	0.8	0.5	1.6	0.8	1.0	-1.6
Neck or shoulder pain in last month	1.2	1.7	6.5	-1.2	-0.1	2.5	0.6	-0.4	0.3	1.8
Chest pain or discomfort	1.2	1.7	6.1	-2.5	0.6	-1.8	1.1	-1.0	0.2	0.4
Medication: Aspirin	1.2	1.5	4.2	-1.2	1.4	-2.0	1.1	1.2	-0.1	-0.8
Ulcerative Colitis (UC)	1.1	2.1	6.2	-2.2	0.4	1.1	-0.8	-2.5	-0.8	-1.2
Systolic Blood Pressure	1.1	5.7	27.9	1.8	-0.5	-2.2	0.2	5.3	-0.5	-1.7
Hypothyroidism (self reported)	1.1	2.6	8.2	2.0	1.5	0.6	1.7	2.9	0.6	0.4
Lung FEV1/FVC ratio	1.1	5.8	17.5	1.1	1.6	-4.2	2.0	2.9	1.9	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	5.0	-2.2	-0.3	1.6	0.1	-0.5	1.0	1.1
Qualifications: CSEs or equivalent	1.1	1.4	4.4	-2.0	0.0	-2.1	0.7	-1.0	0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	9.4	0.0	1.0	-2.2	0.8	3.1	1.3	-0.5
Loud music exposure frequency	1.1	1.2	3.2	-0.3	1.1	0.8	0.9	0.9	1.2	1.8
Birth weight	1.1	2.4	9.9	-1.0	-3.1	-0.1	-1.7	-0.6	-1.4	0.8
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.9	-1.1	-1.5	-0.5	-2.0	-1.1	0.2	0.5
Mood swings	1.1	2.0	6.8	-2.6	0.2	-0.3	-1.3	-1.3	-0.7	-1.7
Breast cancer (self-reported)	1.1	1.4	4.5	-0.1	-1.2	0.9	-0.7	-0.9	-2.1	-1.2
Osteoporosis (self-reported)	1.1	1.4	3.0	-0.2	-1.7	0.7	-1.7	-1.3	-1.2	-0.6
Basal cell carcinoma (self-reported)	1.1	1.3	4.2	1.2	-1.9	2.0	-0.1	0.3	-0.2	-0.4
Fasting Glucose	1.0	1.2	2.5	-1.3	0.0	-1.6	0.4	0.5	-1.2	-1.5
HbA1C	1.0	1.1	2.6	-1.6	-1.3	-1.1	-0.7	-0.2	-1.2	-0.4
Blood Red Count	1.0	9.2	26.7	1.4	-1.9	3.6	-0.1	3.6	-5.2	-2.5
Cardiovascular Disease	1.0	3.4	9.8	2.5	1.1	-1.5	1.5	3.1	0.9	-1.1
Average weekly spirits intake	1.0	1.3	4.1	-0.5	2.0	-0.1	1.6	1.2	-0.7	-0.1
Relative age of first facial hair	1.0	2.1	5.1	-2.3	-1.5	1.3	-1.7	-1.3	-0.2	1.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	4.5	0.6	0.1	2.1	-1.3	0.0	0.1	1.7
Birth weight of first child	1.0	1.8	6.1	-1.6	-2.5	-0.0	-1.5	-0.3	-1.2	-0.2
Pulse wave reflection index	1.0	1.2	4.4	-0.9	-0.0	-1.1	1.0	-0.7	-0.7	-2.1
Glaucoma (self-reported)	1.0	1.2	5.4	0.3	-0.4	-0.6	-1.1	-2.3	0.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.9	0.5	1.5	-0.9	-0.0	1.4	1.7	0.7
Alcohol intake frequency.	1.0	2.2	6.3	-0.6	-0.4	2.5	-0.2	-1.8	1.2	2.0
Ever depressed for a whole week	1.0	1.3	3.5	0.1	0.9	1.3	0.9	1.3	0.7	1.9
Irritable Bowel Disease (IBD)	0.9	2.2	4.6	-2.1	-0.0	1.9	-0.8	-2.0	-1.0	-1.3
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.0	1.0	0.3	1.2	1.0	1.2	0.7	1.7
Diabetes (father)	0.9	1.1	3.0	0.5	0.1	-0.6	1.2	1.7	1.3	0.8
Stomach or abdominal pain in last month	0.9	1.1	2.6	-0.8	0.9	-1.6	1.4	0.9	-0.4	-1.0
Medication: Atenolol	0.9	1.2	4.1	1.2	-0.1	-0.0	0.2	2.0	-1.6	-0.4
Number of incorrect matches in round	0.9	1.5	3.5	-1.7	-1.3	0.0	-1.0	0.6	-1.9	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	5.8	-2.4	0.3	-0.1	1.3	-1.4	0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.4	-0.5	0.0	1.7	-0.0	-0.4	0.8	1.9
Qualifications: None of the above	0.9	2.0	6.2	-0.6	-1.1	1.1	-2.5	-1.3	-1.7	0.2
Time employed in main current job	0.9	1.0	2.4	-0.3	-1.6	-1.0	0.3	0.9	-0.5	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	9.2	0.4	2.2	-0.8	1.7	0.7	3.0	1.0
Impedance of arm (left)	0.9	4.0	8.3	-2.4	-1.9	-1.5	-0.7	-0.5	-2.8	-2.9
Comparative body size at age 10	0.9	2.4	11.4	-2.0	-0.4	-3.4	-0.8	-0.4	0.3	-0.9
Qualifications: College or University degree	0.9	2.9	9.1	2.9	-1.2	-0.1	-0.2	1.2	-0.6	-3.0
Leg pain on walking	0.9	1.2	2.9	0.3	1.6	-0.5	1.0	0.1	1.1	1.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.4	-0.4	0.3	-1.0	-1.4	-1.8	0.1	-1.0
Ever had bowel cancer screening	0.9	1.1	2.7	1.1	0.5	1.6	0.6	1.3	0.5	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	5.0	0.2	0.2	0.8	0.3	2.2	0.8	0.0
Medication: Atorvastatin	0.9	1.1	3.6	0.1	0.2	-1.9	0.7	-1.0	1.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	3.9	0.8	1.1	0.6	2.0	0.6	0.3	0.8
Depression (Nagel 2018)	0.8	1.2	6.7	-2.6	0.1	0.4	-0.1	-1.2	0.0	-0.3
Prostate Cancer	0.8	1.1	2.5	1.1	1.6	1.1	0.9	0.8	1.1	0.5
Triglycerides	0.8	1.3	5.8	0.2	-1.1	2.4	-0.2	-1.3	-0.6	0.5
Blood Eosinophil Count	0.8	6.5	21.4	3.0	-0.1	4.6	-0.8	0.3	1.6	3.4
Allergy or Eczema	0.8	2.1	6.0	-0.3	-1.7	2.0	-1.2	-2.5	0.1	-0.1
Lung FVC	0.8	4.2	8.9	2.2	2.8	-0.8	2.1	0.9	3.0	1.6
Hearing difficulty/problems: Yes	0.8	1.2	2.2	-1.1	-1.5	1.3	0.9	-0.2	1.3	0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.3	0.3	1.1	0.8	1.5	1.1	0.7	0.3
Angina	0.8	1.0	1.7	1.1	1.3	0.7	0.9	1.1	0.5	1.3
Pack years adult smoking proportion	0.8	1.3	3.4	-0.8	0.9	-1.2	-0.4	-0.6	1.9	1.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	0.5	-0.9	-0.9	1.0	0.9	1.3	0.7
Hayfever, allergic rhinitis or eczema	0.8	1.7	5.9	-1.1	-1.1	1.7	-0.6	-2.4	0.4	0.4
Financial difficulties in last 2 years	0.8	1.0	2.8	0.7	-1.2	1.7	0.8	-1.2	0.2	0.6
Impedance of arm (right)	0.8	3.9	7.0	-2.6	-2.2	-1.4	-1.0	-0.6	-2.3	-2.6
Number of live births	0.8	1.1	3.3	-1.7	-0.8	-1.8	0.2	0.0	0.3	-0.6
Prospective memory result	0.8	1.0	3.1	-1.8	-0.2	-0.6	-0.6	-1.2	-0.4	1.3
Pulse wave peak to peak time	0.8	0.9	2.2	-0.3	-0.8	0.7	-1.4	-1.0	-0.3	1.5
Medication: Blood pressure	0.8	1.4	4.9	2.0	-0.5	-0.4	0.3	2.2	-0.3	-0.5
Angina (self-reported)	0.8	1.0	2.2	1.1	1.1	0.5	0.9	1.0	0.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.9	0.4	-1.0	1.4	0.8	-0.2	0.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.1	-0.9	-0.6	1.4	-0.8	0.6	-2.3	-1.6
Average weekly red wine intake	0.8	1.2	4.1	-0.0	-0.6	0.2	0.9	2.0	-0.4	-1.8
Miserableness	0.8	1.5	4.2	-2.0	0.1	1.1	-0.4	-2.0	-0.5	-0.6
Eye problems/disorders: Glaucoma	0.8	0.9	3.7	-0.2	0.2	-0.2	-1.0	-1.9	-0.2	-1.2
Bipolar Disorder (2018)	0.7	1.1	2.9	-0.4	-1.4	1.0	-0.3	-0.8	-1.7	-1.1
Intelligence (Savage-Jansen 2018)	0.7	2.1	8.2	2.9	-0.8	1.1	-0.4	0.7	1.7	0.9
Reaction Time	0.7	1.4	5.6	0.3	2.4	1.3	1.3	0.8	0.1	0.6
Ulcerative Colitis	0.7	1.0	2.7	-1.1	1.0	1.1	-0.2	-1.6	-0.1	-0.8
Blood White Count	0.7	4.9	10.2	1.6	-2.5	3.1	-3.2	1.2	-1.0	1.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	4.0	-2.0	0.1	0.2	-0.1	-1.6	0.2	-0.7
Medication for hormone replacement therapy	0.7	0.8	2.2	1.3	0.5	0.4	1.0	-0.0	1.5	0.8
Average weekly fortified wine intake	0.7	0.8	3.2	0.7	-0.7	0.4	-0.4	1.8	-0.3	1.2
Taking other prescription medications	0.7	1.1	3.3	1.0	0.6	1.8	-0.3	1.4	-0.6	0.8
Mouth/teeth dental problems	0.7	1.1	2.9	1.7	-0.9	-0.8	-0.1	0.7	-0.7	-1.6
Allergy	0.7	1.6	5.2	1.6	0.8	-1.6	0.4	2.3	0.3	0.0
Pulse rate	0.7	1.3	4.5	1.1	0.9	-0.6	0.8	0.3	2.1	1.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.4	0.3	0.6	-0.5	1.1	1.0	0.1	-1.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.3	-0.3	-0.7	1.2	0.1	0.3	1.1	1.5
High blood pressure (siblings)	0.7	1.0	1.7	-0.0	1.0	-1.2	0.7	0.8	-1.2	-1.3
Number of full brothers	0.7	0.8	1.8	0.1	1.3	0.4	1.2	1.0	1.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.0	-1.4	-1.4	0.0	-0.6	-1.1	0.1	0.7
Health satisfaction	0.7	0.9	3.7	1.0	0.4	1.9	0.2	0.6	-0.7	0.8
Illnesses of father: Heart disease	0.7	1.0	3.3	1.3	1.1	0.3	0.7	0.1	1.8	0.7
Medication: Aspirin	0.7	1.0	3.0	-0.7	1.1	-1.7	1.2	0.6	0.2	-0.6
Wears glasses or contact lenses	0.7	0.8	1.9	1.1	0.2	1.4	0.9	0.4	0.4	1.2
Illnesses of father: High blood pressure	0.7	0.9	3.2	-1.8	-1.2	-0.9	0.7	0.0	0.1	-0.4
Alcohol drinker status: Never	0.7	0.8	1.5	1.1	-1.1	0.1	-1.2	0.9	0.9	-0.0
Leg fat percentage (left)	0.7	2.6	6.7	2.6	-0.0	-2.4	1.6	1.3	1.3	-0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.9	0.9	-0.3	-1.2	0.1	0.7	-0.9	-1.4
Age started oral contraceptive pill	0.7	0.8	2.1	-0.3	1.5	-0.9	0.3	1.2	1.1	-0.1
Pack years of smoking	0.7	1.0	2.5	-0.6	1.1	-1.3	-0.2	-0.5	1.6	0.9
Alzheimer’s Disease (in father)	0.6	0.6	2.3	1.5	-1.1	0.1	-0.1	0.7	0.6	-0.2
LDL Cholesterol	0.6	1.0	2.5	0.0	1.6	0.8	1.4	0.4	1.2	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.5	0.5	0.3	-1.1	0.6	0.3	1.6	0.5
Pain all over the body in last month	0.6	0.7	1.8	0.4	0.7	1.1	0.8	-0.0	1.4	0.4
Medication: Ramipril	0.6	0.8	1.7	-0.4	0.9	-1.1	-1.1	1.3	-0.6	-0.2
Illnesses of siblings	0.6	0.9	2.9	-1.1	-1.7	0.0	-0.9	-0.7	0.6	0.7
Father’s age at death	0.6	0.9	2.1	-0.2	-1.5	0.1	-0.9	0.7	-1.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.4	2.1	-0.7	-0.9	-0.5	0.2	-0.7	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-1.3	-0.1	1.2	-0.6	-1.3	-0.1	1.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	4.6	-1.1	-0.0	0.5	-0.5	-2.1	0.3	0.6
Leg fat percentage (right)	0.6	2.2	6.3	2.5	0.2	-2.1	1.5	0.8	1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	-0.8	1.3	-1.1	0.9	0.1	0.7	0.3
Illnesses of siblings: Diabetes	0.6	0.7	2.1	1.4	0.3	0.2	0.4	1.3	0.1	-0.9
Long-standing illness, disability or infirmity	0.6	0.9	2.8	0.7	0.6	1.1	-1.0	-0.5	0.2	1.7
Average weekly champagne plus white wine intake	0.6	0.8	3.0	1.5	0.6	-0.2	-0.2	1.7	-0.4	-0.1
Commuting to job workplace: Cycle	0.6	0.8	2.2	0.5	0.5	-0.7	0.8	0.9	1.5	-0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	2.0	-1.3	-0.6	1.4	0.9	-1.4	-1.3	-0.1
Schizophrenia (2018)	0.5	1.1	2.5	-1.3	0.4	0.7	1.4	-1.6	-0.4	0.7
Crohns Disease (2017)	0.5	1.0	4.0	-0.8	-0.5	2.0	-0.2	-0.4	-0.6	-1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.9	2.0	-1.3	1.0	-1.1	0.5	0.8	0.3
Breast Cancer	0.5	1.3	3.0	0.1	1.4	-1.7	0.8	1.7	0.7	-0.2
Crohns Disease (2012)	0.5	0.7	3.8	0.3	0.1	2.0	0.0	-0.3	-0.1	-1.1
Schizophrenia (2014)	0.5	1.0	3.9	-0.7	-0.3	1.2	0.9	-2.0	-0.1	0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	1.0	-0.2	-1.1	-0.3	1.0	0.7	0.7
Severe depression (siblings)	0.5	0.5	1.8	-0.9	-0.1	0.2	0.8	-1.3	0.4	0.3
Multivitamins +/- minerals	0.5	0.6	2.2	0.1	0.6	0.0	0.8	0.8	0.6	1.5
Supplements: Glucosamine	0.5	0.6	1.6	-0.9	1.3	-0.8	0.1	-0.3	-1.0	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	-0.8	-0.1	1.4	-0.4	-0.6	0.1	0.8
Past tobacco smoking	0.5	1.0	2.4	1.6	0.7	-0.9	0.6	0.7	0.2	-1.5
Hair/balding pattern: Pattern 2	0.5	0.6	2.3	0.5	0.2	0.2	-0.1	-1.5	-1.3	-0.1
Falls in the last year	0.5	0.7	2.4	-1.6	0.3	-0.0	-1.2	-1.1	-0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	5.8	0.9	1.2	-0.3	1.5	1.5	2.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.9	0.7	0.1	1.7	-0.4	0.5	0.4	0.3
Asthma	0.5	0.9	4.8	-2.2	0.7	0.3	-0.1	-0.7	0.3	0.8
Medication: Cholesterol lowering	0.5	0.8	2.4	0.5	0.3	-1.6	1.1	0.8	0.5	-0.8
Lung cancer (father)	0.5	0.6	1.7	0.5	-0.1	0.4	1.3	-0.5	-1.3	-0.0
Body fat percentage	0.5	1.8	6.7	1.7	-1.0	-2.6	0.4	0.0	0.4	-1.4
Worry too long after embarrassment	0.5	0.8	4.4	-2.1	0.1	-0.0	-0.4	-0.6	0.5	0.6
Number of children fathered	0.5	0.6	2.5	-0.4	-0.1	-1.6	0.6	-0.4	-1.0	-0.5
Migraine (self-reported)	0.5	0.6	2.8	-0.8	-1.7	0.0	-0.2	0.7	-0.4	0.1
Medication: Allopurinol	0.5	0.7	3.9	-0.6	0.3	-2.0	-0.6	0.2	-0.1	-0.3
Leg fat mass (right)	0.5	1.8	6.0	2.5	0.1	-1.3	1.1	0.8	1.7	0.2
Arm predicted mass (right)	0.5	2.4	5.2	2.2	-0.1	1.7	-0.1	1.2	2.3	1.6
Knee pain experienced in last month	0.5	0.7	2.5	-1.6	0.6	-0.5	0.6	-1.1	0.0	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.3	0.1	0.6	-1.5	0.6	-0.3	0.6	0.8
Asthma (self-reported)	0.5	1.0	4.7	-2.2	0.6	0.2	0.0	-1.0	0.4	0.7
Number of self-reported non-cancer illnesses	0.5	0.9	2.1	1.4	-1.2	0.5	-0.1	0.8	-0.8	-1.2
Guilty feelings	0.5	0.8	1.9	-0.7	-0.1	1.2	1.0	0.4	1.4	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	-0.4	1.1	1.2	0.7	0.9	0.6	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.7	-1.3	0.7	-0.0	-1.0	-0.2	0.4	0.9
Medication: Bendroflumethiazide	0.5	0.8	3.0	1.0	-0.9	0.2	0.9	1.7	0.2	0.2
Diastolic blood pressure, automated reading	0.5	1.4	4.0	1.2	-0.4	-2.0	-0.6	1.8	0.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	-0.5	0.8	0.7	-0.3	0.5	1.0	1.3
Alcohol drinker status: Previous	0.5	0.6	3.1	-0.7	-0.4	0.7	-0.1	-1.8	-0.3	0.1
Leg fat mass (left)	0.5	1.8	5.8	2.4	-0.0	-1.5	1.1	1.0	1.6	0.1
Schizophrenia vs Biploar Disorder	0.4	0.6	1.1	-0.7	0.7	-0.7	0.6	-0.6	1.0	0.9
Ovarian Cancer	0.4	0.5	1.4	0.6	0.3	1.0	-0.3	0.6	0.3	1.2
Age at First Birth	0.4	0.6	1.3	0.5	0.7	-0.7	-0.2	1.1	0.6	-1.1
Hand grip strength (left)	0.4	1.1	2.4	1.2	0.2	0.8	1.5	1.6	-0.4	-1.0
Vitamin and mineral supplements	0.4	0.6	3.2	0.5	-0.1	-0.4	-0.5	-0.3	0.0	-1.8
Trunk fat percentage	0.4	1.6	5.6	1.2	-1.3	-2.4	0.1	-0.2	-0.0	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	4.0	0.4	-0.2	-1.0	0.0	2.0	0.4	-1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	0.1	0.5	0.5	0.9	0.4	1.1	0.8
Heart attack	0.4	0.6	1.3	0.5	-0.6	-0.5	-1.0	0.1	-1.1	-0.8
Fluid intelligence score	0.4	0.9	3.4	1.9	-0.3	1.0	-0.2	0.2	1.0	0.9
Arm fat percentage (right)	0.4	1.5	6.7	0.2	-0.9	-2.6	-0.0	-0.3	0.3	-1.7
Happiness	0.4	0.5	1.2	-0.8	-0.5	1.1	-0.7	-0.4	-0.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.6	-0.3	-0.2	0.1	-1.6	0.9	0.0	0.2
Hair/balding pattern: Pattern 4	0.4	0.9	3.3	1.8	-0.8	0.9	0.4	0.4	0.4	-1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.1	-1.4	0.9	-0.1	0.3	-0.5	0.2	0.5
Blood clot in the leg (DVT)	0.4	0.6	1.1	-0.5	1.0	0.3	-0.0	0.7	1.0	1.0
Medication: Amlodipine	0.4	0.5	1.3	0.3	-0.9	-1.2	0.1	0.5	0.5	-1.0
Forced vital capacity (FVC), Best measure	0.4	1.3	4.1	-0.1	1.6	0.2	0.9	0.1	2.0	1.3
Arm fat-free mass (right)	0.4	2.0	4.2	2.0	-0.2	1.6	-0.0	1.2	2.0	1.3
Wheeze or whistling in the chest in last year	0.4	0.8	4.3	-2.1	0.8	-0.0	-0.2	0.1	-0.6	0.4
Age at first live birth	0.4	0.8	3.0	1.7	1.0	0.6	0.3	0.7	0.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	3.1	0.1	0.5	-0.4	-0.3	-0.2	-0.0	1.8
Medication: Ibuprofen	0.4	0.5	2.0	-0.3	-0.6	0.9	-1.4	0.6	-0.0	0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	0.8	-0.7	-0.5	-0.2	-1.0	0.2
Comparative height size at age 10	0.4	2.0	7.2	-0.0	-1.0	2.7	-1.4	-0.8	-0.2	1.7
Suffer from ‘nerves’	0.4	0.7	1.6	-1.3	-1.1	0.8	-0.7	-0.8	-0.5	0.0
Overall health rating	0.4	0.8	4.0	0.0	0.4	2.0	-0.5	-0.2	0.0	1.1
Family relationship satisfaction	0.4	0.5	1.6	0.2	0.5	1.2	0.2	0.0	0.5	1.0
Smoking status: Previous	0.4	0.6	1.5	-1.2	-0.8	0.8	-0.4	-0.3	-0.6	0.7
Arm fat percentage (left)	0.4	1.5	6.8	0.5	-0.7	-2.6	0.2	0.1	0.3	-1.7
Eye problems/disorders: Cataract	0.4	0.5	1.6	-1.3	1.1	0.4	0.5	0.1	0.4	-0.0
Mineral and other dietary supplements	0.4	0.5	2.4	1.5	-0.0	-0.7	0.6	0.6	0.0	-0.0
Osteoarthritis (self-reported)	0.4	0.5	1.7	-0.2	-0.9	0.5	-1.3	0.1	-0.7	-0.6
Ever taken oral contraceptive pill	0.4	0.4	2.2	-0.1	0.3	-0.4	1.5	-0.6	0.2	0.3
Mother’s age at death	0.4	0.5	0.8	0.7	-0.4	-0.9	-0.7	0.7	-0.6	-0.9
High cholesterol (Self-reported)	0.4	0.7	2.0	-0.9	-0.7	-1.4	0.1	0.8	0.1	-0.9
Medication: Paracetamol	0.4	0.6	1.4	-0.9	0.1	1.2	-0.3	-0.3	-1.1	0.6
Arm fat-free mass (left)	0.4	1.8	4.5	1.4	-0.4	1.6	-0.4	0.5	2.1	1.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	0.6	-0.3	-0.6	-0.8	0.2	-1.0	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.2	0.8	-1.0	-0.1	0.4	0.5	-0.6
HDL Cholesterol	0.3	0.5	1.1	0.0	0.9	-1.0	0.5	-0.1	1.1	0.3
Lupus	0.3	0.4	1.2	0.8	-1.1	0.0	-0.0	0.1	-0.2	-1.0
BMI	0.3	2.0	4.9	1.7	-1.0	-2.2	0.8	0.5	1.4	-1.6
Waist Hip Ratio (WHR)	0.3	1.5	4.1	-2.0	-1.3	-0.5	-1.9	-0.0	0.1	1.0
Number of treatments/medications taken	0.3	0.5	1.5	-0.2	0.8	0.4	0.6	1.0	-1.2	0.0
Hand grip strength (right)	0.3	0.7	1.4	1.1	-0.3	0.5	1.1	1.2	-0.2	-0.8
Relative age voice broke	0.3	0.5	1.2	-0.4	-0.2	0.9	1.1	0.4	1.1	-0.2
Age when periods started (menarche)	0.3	0.7	1.2	-0.6	-0.4	1.1	0.9	-1.1	0.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	-0.4	-0.5	-0.0	-0.6	-0.4	-0.8	0.9
High blood pressure (mother)	0.3	0.4	1.9	0.6	0.3	-0.1	-0.1	1.4	-0.7	-0.3
Body mass index (BMI)	0.3	1.2	2.7	1.6	0.1	-1.6	0.5	0.1	1.6	-0.0
Forced vital capacity (FVC)	0.3	1.2	3.4	0.3	1.0	1.2	0.9	0.7	1.9	1.2
Medication: Simvastatin	0.3	0.5	2.5	0.2	0.1	-0.6	0.5	1.6	0.1	-0.4
Trunk fat-free mass	0.3	2.0	4.7	1.2	0.1	2.2	-0.3	1.4	1.9	1.5
Hip circumference	0.3	1.5	4.0	2.0	0.4	-1.3	0.7	1.1	1.6	0.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.9	0.0	0.1	-0.6	-0.2	-0.6	1.4	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.6	2.4	-0.6	-0.2	1.0	-0.1	0.2	0.4	1.6
Trunk predicted mass	0.3	1.8	4.7	1.1	-0.0	2.2	-0.3	1.3	1.8	1.3
Breastfed as a baby	0.3	0.4	1.4	1.2	0.4	0.1	0.2	0.1	1.2	-0.3
Headache pain in last month	0.3	0.5	1.4	-0.6	0.4	-0.3	0.6	0.8	0.8	1.2
Eye problems/disorders: None of the above	0.3	0.4	0.7	0.6	-0.8	-0.7	-0.8	0.7	-0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	0.4	0.8	0.3	0.6	0.4	-0.6	-1.0
Whole body fat mass	0.3	1.1	3.1	1.8	-0.7	-1.4	0.5	0.4	1.0	-0.6
Back pain experienced in last month	0.3	0.4	1.2	-1.1	-0.9	0.1	-0.3	0.9	-0.1	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.7	-0.4	0.3	-0.3	-0.7	0.5	-1.3	-0.3
Hearing aid user	0.3	0.4	1.0	-0.7	-0.1	0.9	0.5	1.0	-0.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.3	2.1	-0.3	1.4	0.0	0.1	0.3	-0.1	0.2
Myopia	0.3	0.5	1.2	0.3	0.3	1.1	-0.4	0.6	1.0	0.6
Cholesterol lowering medication	0.3	0.4	1.4	0.4	-0.3	-0.1	0.4	1.0	1.2	-0.3
Heart disease (siblings)	0.3	0.4	1.4	0.0	0.6	-1.2	-0.4	0.3	0.9	-0.2
Impedance of whole body	0.3	1.8	5.7	-1.0	-1.5	-0.8	-0.0	-0.2	-2.4	-1.7
Arm predicted mass (left)	0.3	1.5	3.5	1.5	-0.1	1.4	-0.1	0.9	1.9	1.3
Mean Putamen Volume	0.2	0.3	0.8	-0.9	-0.5	0.3	0.4	0.0	0.3	-0.7
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.6	-0.5	0.2	-0.4	-0.8	-0.9	-0.4
Height	0.2	3.3	13.0	-1.6	-1.7	3.6	-0.9	-1.7	-0.8	0.2
Respiratory disease	0.2	0.5	2.8	-1.7	-0.5	0.8	-0.0	-0.0	0.1	0.3
Impedance of leg (right)	0.2	0.7	1.9	1.1	-0.3	0.1	1.3	0.4	-1.4	-0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.2	-0.6	0.5	-0.1	-0.2	-0.8	0.2
Sitting height	0.2	1.7	4.0	2.0	0.1	1.6	-0.7	1.9	0.6	1.0
Impedance of leg (left)	0.2	1.0	2.3	1.2	-0.7	-0.2	1.4	0.9	-1.5	-0.5
Trunk fat mass	0.2	1.0	2.3	1.5	-1.1	-1.5	0.1	0.3	0.5	-1.0
Waist circumference	0.2	0.7	1.9	1.0	-0.3	-1.1	0.2	0.8	1.4	0.3
Weight	0.2	0.8	2.8	1.4	-0.5	-0.3	0.1	0.6	1.7	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.2	-1.1	0.5	0.3	0.5	0.0	0.6	0.4
Arm fat mass (right)	0.2	0.8	1.9	1.3	-0.6	-1.4	0.2	0.4	1.1	-0.7
Standing height	0.2	1.9	8.9	-0.1	-1.5	3.0	-0.7	1.0	0.4	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	0.4	-0.6	-0.6	0.5	-0.5	-0.7	-0.9
Medication: Paracetamol	0.2	0.4	1.8	-0.7	0.5	-0.0	-0.3	0.4	-1.4	0.3
Gout (self-reported)	0.2	0.3	1.1	-0.5	-0.3	-0.5	-0.4	0.0	-0.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.4	-0.2	-0.5	-0.7	-0.8	-0.3	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.2	-0.3	0.7	0.5	-0.9	0.5	0.3
Pulse rate, automated reading	0.2	0.6	2.2	0.8	-0.6	0.2	-0.1	-0.7	1.5	0.6
Had major operations	0.2	0.2	0.7	0.1	-0.3	-0.8	-0.0	0.6	-0.4	-0.3
Age at last live birth	0.2	0.3	0.8	0.9	-0.2	-0.3	-0.2	-0.3	0.9	0.0
Whole body fat-free mass	0.2	1.4	3.6	0.9	-0.3	1.6	-0.6	0.9	1.9	1.1
Whole body water mass	0.2	1.4	3.9	0.9	-0.3	1.6	-0.6	0.9	2.0	1.2
Arm fat mass (left)	0.2	0.7	1.9	1.0	-0.7	-1.4	0.1	0.4	1.1	-0.5
Basal metabolic rate	0.2	1.0	3.5	0.9	-0.4	1.1	-0.4	0.7	1.9	0.9
Risk taking	0.2	0.3	1.1	-1.0	0.3	-0.8	0.3	0.1	0.1	0.5
Pain experienced in last month	0.2	0.3	0.9	0.3	0.6	-0.7	-0.1	0.4	-0.0	1.0
Supplements: Calcium	0.2	0.2	0.6	0.4	-0.0	0.7	-0.3	-0.6	0.2	0.8
Coronary Artery Disease (CAD)	0.1	0.1	0.6	0.0	0.0	0.0	0.0	0.0	0.3	0.8
Tanning	0.1	0.9	3.5	1.9	-0.9	-0.5	0.5	1.2	-0.2	-0.5
Leg fat-free mass (left)	0.1	0.7	3.1	0.1	-0.6	0.7	-1.1	0.1	1.8	0.4
Leg predicted mass (left)	0.1	0.8	3.3	0.2	-0.5	0.7	-1.0	0.1	1.8	0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.6	0.3	-0.1	0.6	0.2	0.2	0.2
Noisy workplace	0.1	0.1	0.5	-0.1	-0.1	0.4	-0.3	0.7	-0.0	-0.1
Tense / ‘highly strung’	0.1	0.2	0.8	-0.4	-0.9	0.4	-0.4	0.1	-0.4	-0.1
Leg fat-free mass (right)	0.1	0.7	2.7	-0.2	-0.8	0.6	-1.1	0.3	1.6	0.3
Leg predicted mass (right)	0.1	0.7	2.8	-0.2	-0.9	0.5	-1.0	0.4	1.7	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.4	3.5	-1.5	1.9	-1.6	-0.1	-0.9	0.1	0.9

Hub : Genes

TRABD

Models

Trait associations