Hub : Genes

BRD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hypothalamus 0.365 0.134 0.0049 -0.012 NA -0.011 NA -0.007 0.87 NA 0.70 NA 0.50
2 TCGA Skin Cutaneous Melanoma 0.173 0.137 0.0097 -0.006 0.013 -0.002 NA 0.009 0.48 0.14 0.36 NA 0.18

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.4 0.8 0.9 0.2
Bipolar Disorder or Schizophrenia 5.1 12.5 13.2 3.6 -3.4
Depressed Affect (Nagel 2018) 4.4 9.2 13.5 3.7 -2.2
Depression (Nagel 2018) 5.9 8.9 16.2 4.0 -1.3
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.8 0.9 -0.4
Neuroticism (Nagel 2018) 6.0 14.1 18.0 4.2 -3.2
Schizophrenia (2018) 8.1 16.8 18.5 3.9 -4.3
Schizophrenia vs Biploar Disorder 1.0 1.3 2.6 -0.1 -1.6
Worry (Nagel 2018) 3.8 8.1 9.7 3.1 -2.5
Alzheimer’s Disease (in mother) 4.3 5.1 7.3 2.7 -1.7
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.7 -0.1
Alzheimer’s Disease (including proxy) 2.4 3.5 5.9 2.4 -1.1
Crohns Disease (2017) 3.5 7.8 11.1 2.1 -3.3
Irritable Bowel Disease (IBD) 3.3 7.9 9.3 2.5 -3.1
Ulcerative Colitis (UC) 0.8 1.5 1.5 1.2 -1.2
Major Depression (MDD) 0.3 0.3 0.6 -0.0 -0.8
Reaction Time 0.2 0.4 0.8 -0.3 -0.9
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.4 1.2 -0.0
Breast Cancer 0.1 0.1 0.2 -0.5 0.2
Ovarian Cancer 0.5 0.7 1.4 0.1 1.2
Prostate Cancer 0.2 0.3 0.5 0.7 0.4
Age at First Birth 1.6 2.3 2.4 1.5 -1.5
Bipolar Disorder (2011) 0.6 0.6 1.2 1.1 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.5 -1.2 -0.2
Coronary Artery Disease (CAD) 1.6 1.9 3.8 2.0 0.0
Crohns Disease (2012) 2.9 4.7 6.3 1.8 -2.5
Mean Putamen Volume 0.9 1.0 1.1 1.0 -1.0
Fasting Glucose 1.1 1.3 1.6 -1.3 1.0
HbA1C 0.4 0.5 0.8 -0.9 0.4
HDL Cholesterol 0.0 0.0 0.0 -0.1 0.0
LDL Cholesterol 0.1 0.1 0.2 0.2 -0.5
Lupus 0.0 0.0 0.0 -0.1 0.0
Neuroticism (2016) 2.3 3.3 4.3 1.5 -2.1
Primary Biliary Cirrhosis 0.4 0.6 1.0 -1.0 -0.5
Rheumatoid Arthritis 1.0 1.4 2.7 -0.3 1.6
Schizophrenia (2014) 5.3 11.7 12.1 3.4 -3.5
Triglycerides 0.0 0.0 0.0 -0.2 -0.1
Type 2 Diabetes (T2D) (2012) 2.2 2.5 4.9 -2.2 0.4
Ulcerative Colitis 1.4 2.0 2.3 1.3 -1.5
Blood Eosinophil Count 0.1 0.9 1.3 -1.1 0.6
Blood Platelet Count 6.4 74.5 102.0 6.9 -10.1
Blood Red Count 0.6 6.1 8.4 -2.9 2.0
Blood White Count 0.8 5.6 9.5 -3.1 1.3
Heel T-Score 4.6 36.2 42.9 -6.5 5.4
BMI 0.0 0.1 0.2 0.5 0.0
Height 1.2 22.4 23.7 4.6 -4.9
Waist Hip Ratio (WHR) 0.4 1.8 2.9 1.7 0.9
Systolic Blood Pressure 2.6 13.0 21.9 -2.0 4.7
Smoking Status 0.7 1.7 3.2 1.8 -0.4
Allergy or Eczema 1.4 3.6 3.8 -1.9 1.9
Cardiovascular Disease 0.1 0.2 0.2 -0.4 0.4
Hypothyroidism (self reported) 0.6 1.3 2.4 -1.5 0.5
Respiratory disease 0.0 0.0 0.1 0.2 0.1
Type 2 Diabetes (T2D) (2018) 0.6 1.1 1.8 -1.3 0.7
Lung FEV1/FVC ratio 0.3 1.7 2.7 -0.9 1.6
Lung FVC 0.1 0.7 0.8 -0.8 0.9
Neuroticism 6.2 14.9 15.2 3.9 -3.8
Chronotype (morning person) 1.0 2.3 4.0 0.7 -2.0
Hair Pigment 0.1 3.7 3.7 1.9 -1.9
Tanning 1.0 11.8 16.3 -2.7 4.0
Hand grip strength (left) 1.7 4.5 5.7 1.8 -2.4
Number of treatments/medications taken 0.0 0.1 0.1 0.0 -0.4
Average weekly spirits intake 0.2 0.3 0.4 0.6 -0.3
Sensitivity / hurt feelings 0.6 1.0 1.5 0.7 -1.2
Frequency of depressed mood in last 2 weeks 4.7 6.6 8.9 3.0 -2.1
Hearing difficulty/problems: Yes 1.3 2.0 2.4 1.3 -1.6
Relative age of first facial hair 1.6 3.3 6.6 2.6 -0.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.3 1.2 -0.3
Ever used hormone-replacement therapy (HRT) 1.3 1.6 3.2 -0.0 -1.8
Ever had hysterectomy (womb removed) 2.7 3.0 5.8 -2.4 0.5
Systolic blood pressure, automated reading 2.0 5.8 8.1 -1.9 2.8
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 0.6 -0.6 -0.8
Angina 0.4 0.5 0.6 0.8 -0.7
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.4 0.3
Vitamin and mineral supplements 0.8 1.1 1.3 1.0 -1.1
Supplements: Zinc 1.8 2.0 2.9 1.7 -1.0
Medication: Co-codamol 2.8 3.3 3.5 -1.7 1.9
Medication: Metformin 1.0 1.5 2.5 -1.6 0.7
Diabetes (father) 1.5 1.8 3.6 -0.2 1.9
Diabetes (mother) 1.5 1.9 1.9 -1.4 1.3
Severe depression (siblings) 3.6 4.0 6.6 1.2 -2.6
Pack years adult smoking proportion 1.3 1.9 2.2 -1.3 1.5
Impedance of leg (right) 0.0 0.1 0.1 0.3 0.1
Leg fat-free mass (left) 0.4 2.1 3.4 1.8 -0.9
Trunk fat percentage 0.1 0.2 0.4 -0.1 0.6
Hand grip strength (right) 1.1 2.9 3.2 1.8 -1.6
Townsend deprivation index at recruitment 2.1 3.0 3.8 1.5 -2.0
Current tobacco smoking 0.2 0.3 0.5 -0.2 0.7
Average weekly fortified wine intake 0.5 0.6 0.8 -0.6 0.9
Maternal smoking around birth 0.7 1.1 1.1 -1.1 1.0
Fed-up feelings 3.3 6.0 9.0 3.0 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 3.6 4.8 8.7 3.0 -1.0
Relative age voice broke 0.1 0.1 0.2 0.4 0.2
Taking other prescription medications 0.3 0.5 0.8 0.9 -0.5
Age when periods started (menarche) 1.1 2.7 5.3 2.3 -0.4
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.1 0.2 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 3.3 7.4 8.3 -2.6 2.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.7 -0.8 0.4
Qualifications: CSEs or equivalent 1.6 2.1 2.3 -1.4 1.5
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.1 0.5
High blood pressure 0.0 0.1 0.2 -0.4 0.0
Hayfever, allergic rhinitis or eczema 1.8 3.9 4.7 -1.8 2.2
Multivitamins +/- minerals 0.6 0.8 1.5 -1.2 0.3
Stomach or abdominal pain in last month 0.3 0.4 0.7 0.8 -0.2
Supplements: Glucosamine 1.5 2.0 3.7 -1.9 0.6
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.1 -0.2 -0.1
Medication: Atenolol 0.5 0.6 1.2 1.1 0.2
Medication: Levothyroxine sodium 0.4 0.7 1.1 -1.0 0.7
Sitting height 0.7 5.0 7.9 2.8 -1.4
Chronic bronchitis/emphysema (father) 0.2 0.3 0.3 0.5 0.5
High blood pressure (mother) 0.4 0.6 1.1 -0.3 1.1
Body mass index (BMI) 0.2 0.8 1.0 -0.7 1.0
Impedance of leg (left) 0.0 0.1 0.2 -0.4 0.2
Leg predicted mass (left) 0.4 2.2 3.4 1.9 -1.0
Trunk fat mass 0.0 0.1 0.1 0.3 0.4
Waist circumference 0.1 0.2 0.3 0.3 0.6
Number of incorrect matches in round 0.0 0.0 0.0 -0.2 -0.1
Past tobacco smoking 2.5 4.6 6.1 -2.5 1.8
Alcohol usually taken with meals 1.6 2.6 3.4 -1.8 1.3
Nervous feelings 1.2 2.2 2.5 1.6 -1.4
Frequency of tenseness / restlessness in last 2 weeks 6.0 9.3 11.5 3.4 -2.7
Hearing difficulty/problems with background noise 1.6 2.6 3.6 1.3 -1.9
Hair/balding pattern: Pattern 2 0.5 0.7 0.7 0.8 -0.8
Had menopause 0.0 0.1 0.1 -0.3 -0.2
Had other major operations 0.8 1.0 1.7 1.3 -0.6
Forced vital capacity (FVC) 0.1 0.2 0.4 0.2 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 7.2 16.5 17.6 -4.2 3.9
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.2 0.6 -1.1
Qualifications: None of the above 0.3 0.5 1.0 0.3 1.0
Financial difficulties in last 2 years 1.4 1.9 3.8 0.0 -1.9
Mouth/teeth dental problems 0.1 0.1 0.1 -0.3 -0.3
Heart attack 0.5 0.7 1.2 1.1 0.4
Allergy 0.4 1.0 1.6 0.6 -1.2
Pain all over the body in last month 1.8 2.0 3.8 0.4 -1.9
Diabetes (self-reported) 0.2 0.3 0.4 0.3 -0.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.5 -0.1 0.7
Medication: Ramipril 1.5 1.9 2.6 -1.6 1.1
Medication: Simvastatin 0.3 0.4 0.6 -0.5 0.8
Fluid intelligence score 0.1 0.2 0.4 0.1 0.6
Illnesses of siblings 0.0 0.0 0.0 0.1 0.2
Neuroticism score 5.8 12.0 13.9 3.7 -3.2
Weight 0.1 0.4 0.7 0.8 -0.3
Impedance of arm (right) 0.0 0.0 0.1 0.2 -0.1
Arm fat percentage (right) 0.3 1.3 2.0 -0.8 1.4
Trunk fat-free mass 0.3 1.5 2.2 1.5 -0.9
Hip circumference 0.0 0.1 0.2 -0.0 -0.5
Time employed in main current job 0.2 0.2 0.3 0.3 0.5
Alcohol intake versus 10 years previously 2.6 3.9 6.4 -1.2 2.5
Father’s age at death 0.3 0.4 0.8 -0.9 -0.1
Worrier / anxious feelings 1.5 2.9 3.6 1.5 -1.9
Frequency of tiredness / lethargy in last 2 weeks 2.6 4.3 5.8 1.7 -2.4
Falls in the last year 2.6 3.5 4.0 1.7 -2.0
Hair/balding pattern: Pattern 3 1.4 2.1 3.0 -1.7 1.0
Number of live births 1.0 1.5 2.8 -1.7 -0.3
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.0 -0.2 0.1
Pulse rate 2.5 4.3 6.9 -1.3 2.6
Happiness 0.8 1.0 1.1 1.1 -0.9
Noisy workplace 1.8 2.3 3.2 -1.1 1.8
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.0 0.1 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.6 0.7 -0.8
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 0.4 -0.1
Asthma 0.2 0.4 0.7 -0.8 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.2 -0.7 1.1
Medication: Cholesterol lowering 0.2 0.3 0.5 0.2 -0.7
Depression (self-reported) 3.8 4.6 6.0 1.8 -2.5
Medication: Lansoprazole 0.0 0.0 0.0 0.0 -0.2
Prospective memory result 1.0 1.3 2.4 0.4 -1.6
Lung cancer (father) 4.9 5.7 8.2 1.8 -2.9
Illnesses of mother 0.1 0.1 0.2 -0.1 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 0.7 -0.4
Pulse wave Arterial Stiffness index 2.3 2.7 3.2 1.5 -1.8
Impedance of arm (left) 0.0 0.2 0.3 0.6 -0.3
Arm fat mass (right) 0.1 0.6 1.0 -0.4 1.0
Trunk predicted mass 0.3 1.5 2.2 1.5 -0.9
Standing height 1.0 9.8 12.0 3.5 -2.8
Length of working week for main job 0.1 0.1 0.2 0.4 -0.4
Exposure to tobacco smoke at home 2.8 3.2 3.4 1.7 -1.8
Breastfed as a baby 1.8 2.3 2.3 -1.5 1.5
Tense / ‘highly strung’ 1.4 2.4 3.0 1.3 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.2 -0.4
Hair/balding pattern: Pattern 4 0.4 1.1 2.1 0.1 1.5
Birth weight of first child 0.5 0.9 1.5 1.2 -0.5
Peak expiratory flow (PEF) 1.8 4.2 5.2 1.8 -2.3
Pulse wave reflection index 3.3 4.0 6.1 1.4 -2.5
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.2 0.3 0.5
Loud music exposure frequency 0.1 0.2 0.2 -0.3 0.5
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 0.8 0.9 -0.8
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.3 0.6 -0.1
Blood clot in the leg (DVT) 0.9 1.2 2.4 -0.1 1.5
Medication: Paracetamol 0.2 0.3 0.3 0.5 0.6
Headache pain in last month 0.2 0.4 0.8 0.9 -0.1
Medication for cholesterol, blood pressure or diabetes 0.0 0.0 0.0 0.0 0.0
Glaucoma (self-reported) 3.3 3.9 5.9 2.4 -1.4
Gout (self-reported) 0.2 0.3 0.5 0.7 -0.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.1 -1.4 0.8
Medication: Amlodipine 1.5 2.1 2.4 1.3 -1.5
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.0 -1.0 0.7
Birth weight 1.0 2.1 2.5 1.6 -1.3
Chronic bronchitis/emphysema (mother) 2.1 2.5 4.5 2.1 -0.6
High blood pressure (siblings) 0.9 1.3 1.8 0.9 -1.4
Forced vital capacity (FVC), Best measure 0.2 0.8 1.0 1.0 -0.8
Body fat percentage 0.2 0.9 1.3 -0.7 1.1
Leg fat percentage (right) 0.4 1.5 2.1 -1.0 1.4
Arm fat-free mass (right) 0.2 1.3 1.8 1.3 -0.9
Exposure to tobacco smoke outside home 1.4 1.9 3.3 1.8 -0.7
Comparative body size at age 10 0.6 1.6 1.7 -1.2 1.3
Number of full brothers 0.5 0.7 1.1 -1.1 -0.4
Worry too long after embarrassment 0.0 0.1 0.1 0.1 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 1.8 1.4 -1.3
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 0.2 -0.9
Number of children fathered 1.5 1.7 3.0 0.7 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 3.4 0.9 -1.9
Age at first live birth 0.2 0.3 0.5 0.7 -0.2
Pulse wave peak to peak time 2.1 2.5 3.1 -1.4 1.8
Health satisfaction 0.1 0.1 0.2 0.2 -0.5
Shortness of breath walking on level ground 0.9 1.1 2.2 1.5 0.2
Qualifications: College or University degree 0.1 0.4 0.4 -0.6 0.6
Eye problems/disorders: None of the above 1.7 2.0 2.4 -1.5 1.2
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.2 -0.5
Emphysema/chronic bronchitis 1.0 1.1 1.2 1.0 -1.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 0.1 -0.8
Neck or shoulder pain in last month 2.6 3.7 6.3 2.5 -1.1
Medication: Blood pressure 0.1 0.2 0.2 0.5 -0.3
Angina (self-reported) 0.4 0.6 0.7 0.8 -0.7
Migraine (self-reported) 1.6 2.0 2.1 -1.4 1.4
Medication: Ibuprofen 0.2 0.2 0.3 -0.3 0.6
Medication: Allopurinol 0.7 0.9 1.6 -0.5 1.3
Medication: Omeprazole 2.0 2.3 3.0 1.7 -1.3
Medication: Seretide 50 evohaler 0.4 0.5 0.9 0.3 -1.0
Mean time to correctly identify matches 0.4 0.8 1.6 -0.2 -1.3
Heart disease (mother) 0.4 0.5 0.8 0.9 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.3 3.9 5.5 -2.4 1.5
Whole body fat mass 0.0 0.1 0.2 0.1 0.5
Leg fat mass (right) 0.1 0.2 0.4 -0.1 0.6
Arm predicted mass (right) 0.3 1.7 2.0 1.4 -1.2
Pulse rate, automated reading 1.3 4.3 6.7 -1.4 2.6
Alcohol intake frequency. 1.6 3.8 7.2 2.7 -0.7
Comparative height size at age 10 2.3 12.5 16.8 2.9 -4.1
Number of full sisters 1.0 1.3 2.2 -0.6 1.5
Suffer from ‘nerves’ 1.7 2.7 3.6 1.3 -1.9
Overall health rating 0.9 1.9 2.6 1.1 -1.6
Chest pain or discomfort 5.0 7.3 8.4 2.9 -2.5
Had major operations 0.4 0.5 0.9 -0.9 0.3
Age at last live birth 0.4 0.6 0.9 0.9 -0.6
Family relationship satisfaction 2.5 3.1 3.9 1.5 -2.0
Leg pain on walking 0.3 0.4 0.5 -0.6 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.2 -0.7
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.4 -0.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 1.0 0.0
Medication: Aspirin 0.2 0.2 0.4 -0.7 0.1
Supplements: Vitamin C 0.4 0.4 0.6 -0.5 0.8
Knee pain experienced in last month 2.3 3.6 5.2 2.3 -1.4
Hypertension (Self-reported) 0.0 0.1 0.3 -0.5 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.4 0.2
Illnesses of father: Heart disease 3.5 4.9 5.5 2.1 -2.3
Illnesses of siblings: Diabetes 0.2 0.2 0.4 0.6 -0.3
Smoking status: Previous 2.0 3.0 4.0 2.0 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 3.7 1.9 -1.0
Whole body fat-free mass 0.3 1.7 2.3 1.5 -1.0
Leg fat-free mass (right) 0.3 1.8 2.5 1.6 -1.0
Arm fat percentage (left) 0.3 1.3 1.9 -0.8 1.4
Average weekly red wine intake 0.5 0.8 1.5 -0.0 -1.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.1 -0.1 -0.3
Mood swings 2.3 4.2 6.0 2.5 -1.6
Loneliness, isolation 0.4 0.6 0.6 0.8 -0.7
Long-standing illness, disability or infirmity 0.3 0.4 0.6 -0.8 -0.5
Ever had bowel cancer screening 0.4 0.4 0.8 -0.9 0.3
Diabetes diagnosed by doctor 0.3 0.4 0.6 -0.8 0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 1.3 0.9 1.2
Friendships satisfaction 0.9 1.1 1.8 0.6 -1.3
Qualifications: nursing, teaching 0.9 1.3 1.6 -1.3 -1.0
Commuting to job workplace: Walk 0.5 0.5 0.9 -0.4 -0.9
Eye problems/disorders: Cataract 0.1 0.1 0.3 -0.0 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.1 -0.7
Medication for cholesterol 1.0 1.5 2.3 1.5 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.2 0.5
Back pain experienced in last month 0.1 0.1 0.3 0.1 -0.5
Mineral and other dietary supplements 1.3 1.8 3.2 1.8 -0.6
Breast cancer (self-reported) 1.2 1.5 2.9 1.7 -0.1
Asthma (self-reported) 0.2 0.3 0.6 -0.8 0.2
Osteoporosis (self-reported) 0.9 1.1 1.7 1.3 -0.7
Osteoarthritis (self-reported) 2.5 3.2 4.2 -2.1 1.5
Medication: Aspirin 0.1 0.2 0.3 -0.6 0.1
Medication: Gliclazide 0.1 0.1 0.2 0.4 0.1
Illnesses of father: None of the above (group 1) 0.1 0.2 0.3 -0.2 0.6
Smoking status: Current 0.4 0.7 1.2 -0.4 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.5 0.7 -0.7
Whole body water mass 0.3 1.6 2.3 1.5 -1.0
Leg predicted mass (right) 0.3 1.7 2.4 1.5 -1.0
Arm fat mass (left) 0.1 0.3 0.5 0.2 0.7
Number of self-reported non-cancer illnesses 0.3 0.5 0.9 0.3 -1.0
Average weekly champagne plus white wine intake 0.2 0.3 0.3 -0.6 -0.4
Miserableness 3.1 5.4 7.7 2.8 -1.8
Guilty feelings 6.4 9.7 10.8 2.9 -3.3
Wears glasses or contact lenses 1.5 1.8 2.9 0.8 -1.7
Ever taken oral contraceptive pill 3.3 3.6 6.6 -2.6 0.8
Hearing aid user 2.9 3.3 5.7 -0.9 2.4
Mother’s age at death 0.9 1.1 1.6 -1.3 0.8
Financial situation satisfaction 0.0 0.0 0.0 0.1 0.2
Tinnitus: Yes, now most or all of the time 5.9 6.9 8.9 2.2 -3.0
Commuting to job workplace: Public transport 1.1 1.3 1.4 1.2 -1.1
Eye problems/disorders: Glaucoma 1.2 1.5 2.5 1.6 -0.7
Medication: Blood pressure 0.2 0.5 0.9 0.1 -1.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.7 -0.7 0.9
Supplements: Fish oil (including cod liver oil) 3.2 4.2 5.9 -2.4 1.6
High cholesterol (Self-reported) 0.5 0.9 1.0 -1.0 0.9
Medication: Bendroflumethiazide 0.2 0.3 0.4 -0.5 -0.6
Medication: Paracetamol 0.1 0.1 0.1 0.3 0.3
Medication: Lisinopril 0.0 0.1 0.1 0.0 0.3
Medication: Atorvastatin 2.6 3.2 4.3 2.1 -1.5
Illnesses of father: High blood pressure 0.2 0.3 0.6 0.0 -0.7
Alcohol drinker status: Never 0.1 0.1 0.2 0.1 0.5
Ever smoked 3.0 5.2 5.6 2.2 -2.4
Basal metabolic rate 0.2 1.4 2.1 1.5 -0.8
Leg fat percentage (left) 0.7 2.4 2.4 -1.5 1.5
Arm fat-free mass (left) 0.3 1.5 2.0 1.4 -1.1
Number of operations (self-reported) 0.6 0.9 1.2 0.8 -1.1
Average weekly beer plus cider intake 0.0 0.1 0.1 0.2 0.2
Irritability 5.0 8.5 9.7 3.1 -2.7
Risk taking 0.1 0.2 0.3 -0.6 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.9 0.3 -0.9
Fractured/broken bones in last 5 years 3.2 4.2 5.1 2.3 -1.8
Age started oral contraceptive pill 0.3 0.4 0.7 0.2 -0.8
Diastolic blood pressure, automated reading 1.5 4.7 7.6 -1.3 2.8
Ever depressed for a whole week 0.3 0.4 0.4 0.5 -0.7
Unable to work because of sickness or disability 3.1 4.0 4.8 2.2 -1.8
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.4 0.0
Myopia 0.9 1.3 2.1 1.4 -0.6
Vascular/heart problems diagnosed by doctor 0.0 0.0 0.0 0.0 0.0
Cholesterol lowering medication 0.6 0.9 1.6 -0.3 1.3
Medication: Omeprazole (e.g. Zanprol) 2.9 3.5 5.4 2.3 -1.3
Pain experienced in last month 1.9 3.1 4.1 -1.5 2.0
Supplements: Calcium 0.1 0.1 0.2 0.2 -0.4
Basal cell carcinoma (self-reported) 0.2 0.3 0.3 -0.6 -0.5
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.3 1.1 0.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.0 -0.2 1.4
Heart disease (siblings) 0.3 0.4 0.6 -0.8 0.4
Alcohol drinker status: Previous 10.4 11.9 16.1 4.0 -2.8
Pack years of smoking 1.5 2.2 2.9 -1.2 1.7
Impedance of whole body 0.0 0.2 0.3 0.5 -0.3
Leg fat mass (left) 0.1 0.3 0.4 -0.4 0.6
Arm predicted mass (left) 0.3 1.4 1.9 1.4 -1.0