Hub : Genes

MLC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0520 0.0190 7.6e-04 0.007 0.022 0.012 0.02 0.009 4.2e-02 8.2e-04 1.2e-02 0.0016 2.6e-02
2 TCGA Bladder Urothelial Carcinoma 0.0670 0.0320 6.7e-04 0.048 0.062 0.056 NA 0.046 5.8e-05 6.3e-06 1.7e-05 NA 8.2e-05
3 TCGA Breast Invasive Carcinoma 0.1183 0.0302 0.0e+00 0.116 0.107 0.109 NA 0.113 8.4e-23 4.9e-21 2.0e-21 NA 2.5e-22
4 TCGA Cervical Squamous Cell Carcinoma 0.2830 0.0770 1.5e-07 0.185 0.133 0.174 NA 0.179 1.9e-09 4.7e-07 5.9e-09 NA 3.5e-09
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0335 0.0165 2.0e-03 0.018 0.026 0.000 NA 0.012 3.2e-03 6.2e-04 3.3e-01 NA 1.4e-02
6 TCGA Lung Adenocarcinoma 0.1209 0.0446 7.6e-09 0.039 0.068 0.073 NA 0.068 2.0e-05 2.4e-08 7.2e-09 NA 2.0e-08
7 TCGA Lung Squamous Cell Carcinoma 0.0394 0.0185 2.8e-04 0.043 0.032 0.038 NA 0.045 1.1e-05 1.3e-04 3.2e-05 NA 6.9e-06
8 TCGA Ovarian Serous Cystadenocarcinoma 0.1340 0.0580 6.4e-05 0.024 0.055 0.042 NA 0.027 9.4e-03 1.4e-04 8.0e-04 NA 6.0e-03
9 TCGA Pancreatic Adenocarcinoma 0.2150 0.0690 2.0e-07 0.149 0.156 0.188 NA 0.192 8.4e-07 4.2e-07 2.4e-08 NA 1.7e-08
10 TCGA Prostate Adenocarcinoma 0.0931 0.0322 6.9e-10 0.065 0.096 0.093 NA 0.110 2.2e-07 3.1e-10 5.8e-10 NA 1.3e-11
11 TCGA Rectum Adenocarcinoma 0.2350 0.0970 1.6e-03 0.180 0.042 0.089 NA 0.025 5.3e-05 3.8e-02 4.1e-03 NA 8.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.1 0.2 0.4 -0.4 0.5 0.4 0.2 -0.7 0.4 0.5 -0.4 0.0 0.4 0.5
Bipolar Disorder or Schizophrenia 0.7 1.7 5.0 -0.2 2.2 1.5 1.6 0.6 1.3 0.5 0.7 1.4 1.8 1.0
Depressed Affect (Nagel 2018) 1.3 2.7 6.4 2.5 1.4 1.9 1.6 -2.4 0.6 -1.9 -1.9 0.9 0.2 -0.6
Depression (Nagel 2018) 0.6 0.8 2.7 -0.0 0.4 1.4 1.2 -0.9 1.6 -0.3 -0.7 0.9 0.7 0.4
Intelligence (Savage-Jansen 2018) 1.4 4.3 10.4 0.6 -1.2 -3.0 -3.0 0.4 -3.2 -0.7 -0.0 -2.5 -2.5 -2.0
Neuroticism (Nagel 2018) 1.0 2.4 5.2 2.3 1.6 2.2 1.9 -1.6 1.5 -0.6 -1.3 1.5 0.9 -0.4
Schizophrenia (2018) 1.1 2.3 6.0 0.0 2.4 1.6 1.9 1.2 1.4 0.2 1.2 1.7 2.0 1.2
Schizophrenia vs Biploar Disorder 0.3 0.4 1.0 -0.0 0.1 0.5 0.7 0.8 0.6 0.1 1.0 1.0 0.6 0.3
Worry (Nagel 2018) 0.8 1.6 3.4 1.6 1.4 1.6 1.3 -1.2 1.8 0.5 -0.3 1.5 1.1 0.4
Alzheimer’s Disease (in mother) 1.2 1.4 7.2 -1.5 0.9 -1.0 -0.5 2.7 -0.3 0.1 1.6 -0.3 -0.1 -1.0
Alzheimer’s Disease (in father) 0.9 0.9 2.3 -0.1 -0.8 -1.4 -1.5 0.2 -1.2 0.0 -0.5 -1.4 -1.0 -0.7
Alzheimer’s Disease (including proxy) 0.8 1.2 2.8 -1.0 0.2 -1.5 -1.3 1.7 -1.0 -0.2 0.4 -1.1 -1.0 -1.4
Crohns Disease (2017) 0.2 0.4 1.3 -0.4 -0.1 -0.5 -0.8 -1.0 0.4 1.2 0.1 -0.4 -0.1 0.5
Irritable Bowel Disease (IBD) 0.4 0.9 3.1 0.4 1.0 1.0 0.8 -1.8 1.4 0.5 -0.2 0.7 0.6 0.7
Ulcerative Colitis (UC) 1.1 2.1 4.3 0.6 1.7 2.0 1.9 -1.7 2.1 0.2 0.0 1.5 1.3 1.1
Major Depression (MDD) 0.2 0.3 1.6 0.0 0.0 0.3 0.5 0.0 0.0 0.0 0.0 0.9 1.3 0.0
Reaction Time 0.3 0.5 1.8 -1.3 0.6 0.2 0.3 0.8 0.7 0.3 1.4 0.0 0.7 0.1
Verbal and Numeric Reasoning (VNR) 0.7 1.6 3.4 0.4 -0.9 -1.6 -1.7 -0.3 -1.8 -0.3 -0.4 -1.1 -1.8 -1.6
Breast Cancer 0.9 2.2 5.5 2.3 1.6 1.9 1.8 -0.7 1.6 0.6 -0.4 1.5 1.5 1.1
Ovarian Cancer 0.3 0.4 1.7 -0.9 -0.5 -0.3 -0.1 0.5 -0.5 -0.8 0.2 -0.2 -0.5 -1.3
Prostate Cancer 0.4 0.6 2.5 -1.6 -1.2 -0.3 -0.3 0.6 0.0 -0.1 0.3 -0.4 -0.2 -1.3
Age at First Birth 1.2 1.7 4.8 2.0 -1.0 -0.6 -0.7 -2.2 -1.3 -0.9 -1.6 -1.0 -1.5 0.1
Bipolar Disorder (2011) 0.1 0.1 0.3 0.0 0.5 0.0 -0.1 -0.1 0.0 0.3 -0.5 -0.1 0.1 0.4
Body Mass Index (BMI) (2010) 0.2 0.2 1.2 1.1 -0.0 0.4 0.3 -0.6 -0.4 -0.5 -0.3 -0.3 0.2 0.2
Coronary Artery Disease (CAD) 0.2 0.2 0.7 0.0 0.3 -0.3 -0.5 0.6 0.0 -0.7 0.4 -0.8 -0.1 -0.4
Crohns Disease (2012) 0.1 0.2 1.0 -0.4 -0.3 -0.2 -0.5 -1.0 0.1 0.9 0.1 -0.3 -0.1 0.2
Mean Putamen Volume 0.5 0.6 2.2 -0.0 0.1 -1.0 -0.9 0.2 -0.6 0.5 1.0 -0.9 -0.1 1.5
Fasting Glucose 3.6 4.3 9.5 0.3 2.1 3.0 3.1 -0.3 2.0 1.6 0.4 2.8 2.9 1.2
HbA1C 3.3 3.7 12.0 0.3 2.1 3.0 3.5 -1.0 1.6 -0.4 -1.0 2.8 1.4 0.7
HDL Cholesterol 0.0 0.1 0.2 -0.2 -0.5 -0.2 -0.1 0.5 0.2 0.1 0.2 -0.2 0.1 -0.4
LDL Cholesterol 0.4 0.7 4.6 -2.1 0.1 0.1 0.2 0.7 0.2 0.0 1.0 0.2 0.6 0.9
Lupus 0.1 0.2 0.6 0.0 0.5 0.2 0.1 -0.6 0.1 0.7 -0.1 0.3 0.2 0.8
Neuroticism (2016) 2.2 3.2 5.7 0.3 2.1 2.4 2.4 -0.0 2.0 1.4 0.3 2.4 2.3 1.3
Primary Biliary Cirrhosis 0.5 0.7 1.8 -1.4 0.0 0.7 0.7 0.4 1.0 1.1 0.4 1.3 0.6 0.2
Rheumatoid Arthritis 0.5 0.7 2.8 -0.2 -1.1 0.3 -0.0 -1.7 -0.8 -0.2 -1.6 -0.3 -0.3 -0.1
Schizophrenia (2014) 0.8 1.7 3.9 -0.8 2.0 1.4 1.7 0.9 1.1 0.0 0.9 1.5 1.6 1.1
Triglycerides 0.9 1.5 6.0 -2.5 1.4 0.2 0.4 1.4 0.9 1.2 1.7 0.7 0.8 0.7
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.2 -0.5 0.6 0.9 0.8 0.7 0.2 0.6 0.7 0.5 1.1 0.0
Ulcerative Colitis 0.5 0.8 2.0 0.5 0.7 1.2 1.2 -1.4 1.4 -0.3 0.0 0.8 0.6 -0.1
Blood Eosinophil Count 1.6 12.6 24.2 -4.1 -1.9 -4.9 -4.2 2.9 -4.0 -2.2 2.0 -4.1 -3.5 -3.6
Blood Platelet Count 2.2 24.9 86.5 -6.8 2.5 -3.6 -2.0 5.4 -3.8 -6.0 4.3 -1.9 -3.9 -9.3
Blood Red Count 0.4 3.4 13.5 -3.7 -0.1 0.0 0.2 0.8 1.3 3.4 1.9 1.1 1.2 2.0
Blood White Count 1.5 11.3 17.6 -1.2 -4.0 -4.2 -4.0 1.0 -4.2 -2.8 -0.7 -4.0 -4.2 -3.6
Heel T-Score 0.8 6.6 36.8 6.1 0.7 1.4 0.9 -3.0 1.6 2.6 -1.4 1.4 1.2 2.9
BMI 0.1 0.4 1.1 0.9 -0.1 -0.7 -0.8 -0.5 0.3 0.2 -0.2 -1.1 -0.3 1.0
Height 0.0 0.8 3.1 -1.8 1.7 0.0 0.3 -0.5 -0.9 -0.8 0.8 -0.1 0.0 0.7
Waist Hip Ratio (WHR) 0.4 2.0 3.6 -1.3 -1.6 -1.5 -1.6 -0.4 -1.2 -1.4 -0.8 -1.9 -1.7 -1.6
Systolic Blood Pressure 0.1 0.4 1.9 0.4 -0.4 0.5 0.2 -0.7 0.5 1.1 -0.2 0.6 0.5 1.4
Smoking Status 0.8 1.8 4.6 1.6 0.5 0.7 0.6 -1.4 -0.7 -2.2 -2.0 0.2 -0.8 -2.1
Allergy or Eczema 0.8 2.2 8.1 -2.9 -0.8 -2.0 -1.7 1.4 -1.0 0.5 1.6 -1.4 -0.8 0.3
Cardiovascular Disease 0.1 0.4 2.3 0.5 -0.2 0.6 0.5 -0.7 -0.3 0.4 -0.1 0.2 0.4 1.5
Hypothyroidism (self reported) 0.6 1.3 4.0 -1.6 0.3 -0.1 0.1 2.0 0.3 1.4 1.8 0.7 0.7 1.1
Respiratory disease 0.3 0.7 2.2 -1.2 1.5 0.4 0.6 0.5 0.5 0.5 1.3 0.8 0.7 -0.1
Type 2 Diabetes (T2D) (2018) 1.3 2.5 4.2 1.7 2.0 2.0 1.9 -1.1 1.3 0.8 0.2 1.5 1.7 1.9
Lung FEV1/FVC ratio 0.3 1.6 4.9 1.9 0.7 1.2 0.9 -2.2 0.2 -0.4 -1.6 0.1 0.7 1.9
Lung FVC 0.2 1.0 4.2 -1.6 0.2 -0.6 -0.2 2.1 -0.1 0.8 1.7 0.2 0.2 0.4
Neuroticism 1.7 4.1 8.4 2.9 2.3 2.7 2.3 -2.6 1.7 -0.9 -1.8 1.8 1.2 0.5
Chronotype (morning person) 0.2 0.4 1.0 -0.6 0.2 -1.0 -0.9 0.4 -0.7 0.2 -0.2 -0.6 -0.8 -0.4
Hair Pigment 0.0 0.7 3.3 1.8 -0.3 0.6 0.8 -0.0 0.2 -1.4 -0.6 0.5 -0.0 -1.2
Tanning 0.1 1.2 3.2 -1.8 -0.3 -1.0 -0.8 1.8 -1.0 1.5 0.8 -0.5 0.0 1.0
Hand grip strength (left) 0.6 1.5 5.8 -0.6 1.1 0.0 0.2 0.7 0.8 2.2 1.1 0.8 1.2 2.4
Number of treatments/medications taken 0.4 0.7 1.9 -0.2 1.4 0.8 0.8 0.5 0.9 0.9 0.8 1.1 1.0 0.5
Average weekly spirits intake 0.3 0.3 1.0 -0.4 0.1 0.3 0.3 0.8 1.0 0.5 0.5 0.4 0.7 0.8
Sensitivity / hurt feelings 0.6 1.0 2.0 0.8 1.1 1.3 1.1 -0.1 1.4 1.2 -0.3 1.3 1.1 0.9
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.6 0.5 0.5 1.1 0.9 -1.3 0.8 -0.1 -0.6 0.4 0.6 0.6
Hearing difficulty/problems: Yes 0.4 0.5 1.8 -0.9 1.3 0.5 0.8 -0.2 -0.1 -0.5 0.4 0.6 0.4 1.2
Relative age of first facial hair 0.3 0.6 2.8 -0.5 0.3 0.0 0.0 -1.1 -0.7 -1.7 -1.0 -0.6 -0.7 -0.6
Other serious medical condition/disability diagnosed by doctor 4.2 5.4 9.3 -0.9 -2.6 -2.8 -2.8 0.5 -3.0 -2.3 -0.6 -3.1 -2.7 -2.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.3 -0.4 0.2 -1.2 -1.1 1.5 -1.1 0.6 1.1 -0.5 -0.6 -0.6
Ever had hysterectomy (womb removed) 0.5 0.6 2.0 1.4 0.5 0.5 0.5 -0.5 -0.1 -1.2 -0.5 0.4 -0.3 -1.1
Systolic blood pressure, automated reading 0.3 1.0 3.0 1.7 -1.1 -0.1 -0.6 -1.6 -0.7 0.1 -1.4 -0.4 -0.6 0.9
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 6.1 0.1 2.5 1.3 1.4 0.4 1.7 1.0 1.0 1.6 1.7 1.3
Angina 0.3 0.4 1.2 0.0 0.4 -0.6 -0.5 1.1 -0.8 -0.2 0.6 -0.5 -0.3 -0.9
Medication for hormone replacement therapy 0.5 0.5 1.5 -0.2 1.2 0.4 0.4 0.6 0.7 1.0 0.7 1.0 0.5 -0.6
Vitamin and mineral supplements 0.5 0.6 2.5 0.1 -1.4 -0.3 -0.7 -1.6 -0.3 0.7 -0.4 -0.7 -0.4 0.7
Supplements: Zinc 0.4 0.5 1.0 -0.1 -0.6 -0.8 -0.4 1.0 -0.7 -0.9 -0.1 -0.4 -0.7 -1.0
Medication: Co-codamol 1.2 1.4 4.8 -1.4 -0.7 -1.7 -1.6 2.2 -0.2 0.4 1.0 -1.1 -0.8 -0.0
Medication: Metformin 1.1 1.5 5.5 2.3 1.0 1.5 1.3 -1.8 0.6 -0.3 -1.1 0.6 0.7 0.0
Diabetes (father) 0.8 1.0 2.0 -0.4 1.4 1.1 1.3 -0.2 1.4 0.0 0.4 1.2 1.0 1.3
Diabetes (mother) 0.6 0.7 3.5 -0.5 0.1 0.7 0.8 0.0 0.6 1.1 0.4 0.7 0.9 1.9
Severe depression (siblings) 0.9 1.1 2.1 -0.9 1.1 0.5 0.6 0.9 0.8 1.4 1.4 1.1 1.0 1.2
Pack years adult smoking proportion 0.8 1.2 4.0 1.0 -0.4 -0.2 -0.2 -0.2 -1.4 -2.0 -1.2 -1.0 -0.7 -1.6
Impedance of leg (right) 0.4 1.7 3.3 -0.9 1.0 1.0 1.2 1.0 1.4 1.7 1.3 1.8 1.6 1.2
Leg fat-free mass (left) 0.7 3.5 7.4 -0.5 -1.6 -2.3 -2.3 -0.3 -2.4 -1.8 -0.4 -2.7 -2.3 -1.7
Trunk fat percentage 0.1 0.3 0.7 0.7 -0.4 -0.4 -0.5 -0.6 0.1 -0.2 -0.5 -0.8 -0.3 0.6
Hand grip strength (right) 0.4 1.2 4.2 -1.0 1.0 0.1 0.3 0.3 0.6 1.9 0.8 1.0 0.8 2.1
Townsend deprivation index at recruitment 0.4 0.5 3.0 0.8 1.1 0.4 0.3 -0.4 -0.0 -0.6 -0.2 -0.0 0.2 -1.7
Current tobacco smoking 1.5 2.5 9.7 1.2 -0.6 -0.0 -0.0 -0.7 -1.6 -2.4 -2.1 -0.6 -1.5 -3.1
Average weekly fortified wine intake 0.9 1.0 2.0 -1.4 -0.5 -1.3 -1.2 1.3 -0.5 -0.2 0.9 -0.9 -0.8 -1.4
Maternal smoking around birth 1.5 2.1 6.9 -1.1 -0.0 -1.5 -1.2 1.7 -0.8 -2.1 0.7 -0.8 -1.6 -2.6
Fed-up feelings 2.1 3.8 8.5 1.2 2.6 2.9 2.9 -1.5 2.0 -0.8 -1.1 2.4 1.6 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.0 -1.2 0.9 1.1 1.2 0.4 1.4 -0.7 0.2 1.0 0.7 -0.2
Relative age voice broke 0.6 1.0 3.5 -1.9 0.4 -0.0 0.1 0.7 0.2 1.2 1.8 0.1 0.8 1.1
Taking other prescription medications 0.5 0.7 2.1 -0.6 -0.9 -0.8 -0.9 0.1 -1.4 -0.6 0.1 -0.8 -1.0 -1.1
Age when periods started (menarche) 1.1 2.6 12.9 -3.6 0.9 -0.4 0.1 2.7 0.3 1.4 1.9 0.4 1.1 1.0
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.5 -1.1 1.6 0.9 1.2 0.4 -0.1 -0.2 0.3 1.2 0.5 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 2.7 1.6 -0.1 -0.7 -0.7 -1.1 -0.3 0.9 0.1 -0.5 -0.2 0.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.3 -0.4 1.0 -0.5 -0.3 1.1 0.3 0.5 0.8 -0.2 0.2 0.6
Qualifications: CSEs or equivalent 1.6 2.2 5.2 -0.8 1.4 1.9 2.2 0.9 1.3 0.4 0.3 1.3 2.3 1.7
Serious illness, injury or assault to yourself 0.5 0.6 1.3 -1.0 -0.3 -1.1 -1.1 0.7 -0.3 -0.2 0.7 -1.1 -0.4 -0.3
High blood pressure 0.2 0.5 2.7 0.4 0.9 0.1 0.1 -0.2 0.0 1.1 0.8 0.5 0.3 1.6
Hayfever, allergic rhinitis or eczema 0.8 1.6 8.0 -2.8 0.2 -1.2 -0.8 1.5 -0.1 0.5 2.2 -0.5 -0.1 0.7
Multivitamins +/- minerals 0.3 0.4 2.3 0.4 0.9 -0.2 0.1 1.5 0.0 -0.6 0.4 0.0 0.1 -0.7
Stomach or abdominal pain in last month 0.9 1.1 2.3 0.4 0.9 1.2 1.1 -0.3 1.1 1.0 0.8 0.9 1.5 1.5
Supplements: Glucosamine 1.5 2.0 4.7 1.1 1.1 2.2 2.1 -0.1 1.7 0.6 -0.4 1.9 1.6 0.8
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.8 -0.7 -1.7 -1.6 -1.5 1.4 -0.4 0.1 0.8 -1.2 -0.8 -0.4
Medication: Atenolol 0.4 0.5 1.2 0.0 1.0 0.8 0.9 0.3 0.7 0.5 0.2 1.1 0.7 0.9
Medication: Levothyroxine sodium 0.5 0.8 3.0 -1.7 0.9 -0.3 -0.0 1.4 0.2 0.8 1.3 0.4 0.4 0.6
Sitting height 0.8 5.7 12.3 0.4 -2.3 -3.0 -3.0 -0.4 -3.5 -1.7 -0.5 -2.6 -3.3 -2.5
Chronic bronchitis/emphysema (father) 0.6 0.7 2.5 -1.6 -0.5 -1.0 -0.9 0.6 -0.6 -0.5 0.5 -1.0 -0.5 -0.6
High blood pressure (mother) 0.1 0.2 0.5 0.3 0.1 -0.6 -0.7 -0.0 -0.5 0.6 0.4 -0.5 -0.3 0.5
Body mass index (BMI) 0.1 0.6 2.0 0.0 -0.4 -1.3 -1.3 0.4 -0.5 -0.2 0.2 -1.4 -0.8 -0.0
Impedance of leg (left) 0.4 2.1 4.1 -0.8 1.4 1.2 1.4 0.9 1.7 1.7 1.1 2.0 1.7 1.5
Leg predicted mass (left) 0.7 3.6 7.7 -0.5 -1.6 -2.3 -2.4 -0.3 -2.5 -1.8 -0.3 -2.8 -2.3 -1.7
Trunk fat mass 0.1 0.6 2.0 0.2 -0.6 -1.1 -1.2 -0.3 -0.7 -0.5 -0.2 -1.4 -0.9 0.2
Waist circumference 0.4 1.5 4.1 -0.3 -0.8 -2.0 -1.9 0.3 -0.9 -0.7 0.4 -2.0 -1.4 -0.8
Number of incorrect matches in round 0.2 0.4 1.5 0.9 0.3 -0.0 -0.2 -0.8 0.1 -0.5 -0.9 -0.5 -0.3 -1.2
Past tobacco smoking 0.4 0.8 3.3 0.1 -0.2 0.3 0.2 -0.5 1.1 1.6 0.6 0.5 0.8 1.8
Alcohol usually taken with meals 0.5 0.9 2.5 0.6 -1.5 -0.7 -1.2 -1.6 -0.5 0.7 -0.7 -0.7 -0.8 0.6
Nervous feelings 0.3 0.5 1.7 0.8 0.4 0.7 0.5 -0.6 1.3 0.9 -0.2 0.9 0.7 0.5
Frequency of tenseness / restlessness in last 2 weeks 3.7 5.8 10.9 -0.1 3.3 3.2 3.3 -0.3 3.0 0.9 0.2 3.2 2.9 1.9
Hearing difficulty/problems with background noise 1.4 2.3 4.4 -0.5 1.8 1.8 2.0 0.3 1.2 0.9 1.3 1.6 2.0 2.1
Hair/balding pattern: Pattern 2 1.0 1.2 3.2 -0.5 0.5 1.3 1.1 0.8 1.8 1.5 0.3 1.6 1.3 0.2
Had menopause 0.2 0.2 0.7 -0.1 -0.2 -0.5 -0.6 0.0 -0.6 -0.1 -0.3 -0.3 -0.6 -0.8
Had other major operations 0.2 0.2 2.0 -1.4 0.2 -0.3 -0.3 0.3 -0.2 0.3 -0.1 -0.1 -0.1 0.0
Forced vital capacity (FVC) 0.2 0.6 2.2 -1.5 0.7 0.1 0.5 0.7 -0.2 0.1 1.4 0.9 0.2 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 2.1 1.5 1.2 0.7 0.9 -0.4 1.1 1.2 0.8 1.0 1.1 0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.1 -0.8 0.9 -0.3 0.1 1.2 0.0 0.1 1.5 0.3 0.0 -0.1
Qualifications: None of the above 0.3 0.6 2.0 0.0 -0.5 0.9 0.8 -0.7 0.2 -0.8 -1.2 0.5 -0.2 -1.4
Financial difficulties in last 2 years 0.3 0.4 1.5 -1.0 0.1 -0.4 -0.2 1.2 0.1 0.5 0.6 -0.1 0.2 0.7
Mouth/teeth dental problems 0.4 0.6 3.4 0.0 -0.5 -0.0 -0.2 -1.0 0.0 1.2 0.2 0.1 0.2 1.8
Heart attack 0.3 0.4 1.3 0.7 -0.5 -0.0 -0.3 -0.8 -0.3 -0.0 -1.1 -0.3 -0.5 -1.0
Allergy 0.9 2.0 8.9 3.0 -1.0 0.4 0.0 -1.6 -0.7 -1.1 -2.5 -0.4 -0.7 -0.8
Pain all over the body in last month 2.2 2.4 5.6 0.2 2.4 2.0 1.9 -0.3 2.1 0.5 1.0 1.9 1.7 0.7
Diabetes (self-reported) 1.3 2.0 4.6 1.9 1.8 2.1 2.1 -1.3 0.6 -0.3 -0.6 1.4 1.4 0.7
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.7 -0.4 0.7 0.7 0.9 0.7 1.3 0.2 1.2 1.1 0.9 0.6
Medication: Ramipril 1.1 1.4 7.1 2.3 0.4 0.5 0.1 -2.7 -0.4 -0.5 -1.2 0.2 -0.6 -0.6
Medication: Simvastatin 0.0 0.1 0.2 0.1 -0.5 -0.2 -0.3 -0.0 -0.3 -0.2 0.1 -0.5 -0.2 -0.1
Fluid intelligence score 0.4 0.8 2.3 -0.1 -0.2 -1.3 -1.3 0.4 -1.5 -0.0 0.4 -1.0 -1.1 -0.4
Illnesses of siblings 0.3 0.4 1.4 -0.2 -0.4 -0.6 -0.5 0.4 -1.0 -0.6 -0.5 -0.7 -0.5 -1.2
Neuroticism score 1.5 3.2 7.7 1.6 2.8 2.4 2.2 -1.5 2.1 -0.0 -0.7 2.1 1.5 0.7
Weight 0.3 1.5 3.7 -0.7 -0.7 -1.9 -1.8 0.4 -1.4 -0.8 0.4 -1.9 -1.4 -0.5
Impedance of arm (right) 0.5 2.5 5.4 1.0 0.2 2.3 2.1 -1.9 1.8 0.6 -1.0 1.8 1.6 1.4
Arm fat percentage (right) 0.1 0.3 0.8 0.5 -0.3 -0.2 -0.4 -0.8 0.5 -0.1 -0.5 -0.9 -0.1 0.7
Trunk fat-free mass 0.7 3.8 7.7 -1.7 -1.1 -2.8 -2.6 0.8 -2.6 -1.2 0.7 -2.5 -2.3 -1.7
Hip circumference 0.2 1.0 1.9 1.3 -0.5 -1.4 -1.4 -0.0 -0.8 -0.9 0.0 -1.4 -1.2 -0.6
Time employed in main current job 1.1 1.3 3.2 -0.6 0.8 0.6 0.6 0.4 1.7 1.8 1.1 1.2 1.1 1.3
Alcohol intake versus 10 years previously 2.0 3.0 9.7 -3.1 1.8 -0.2 0.2 2.7 1.2 1.1 2.9 0.5 1.2 -0.1
Father’s age at death 1.0 1.4 3.0 0.4 -1.6 -1.6 -1.7 -1.2 -1.0 -0.1 -0.4 -1.4 -1.4 0.7
Worrier / anxious feelings 2.3 4.3 9.2 1.5 2.0 3.0 2.9 -1.6 2.9 0.7 -0.4 2.7 2.1 0.9
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.5 0.6 1.9 1.7 1.8 -0.4 1.5 -0.2 0.0 1.5 1.4 0.9
Falls in the last year 1.7 2.3 5.8 2.4 -0.9 0.7 0.2 -1.9 -1.0 -1.9 -2.3 -0.2 -0.9 -1.8
Hair/balding pattern: Pattern 3 0.1 0.1 0.4 0.5 0.2 -0.0 -0.1 -0.6 -0.3 0.0 -0.1 -0.5 0.1 0.3
Number of live births 0.7 1.0 2.3 0.5 0.8 1.1 1.2 0.5 1.5 0.9 0.2 1.0 1.4 1.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.2 -0.8 0.8 0.4 0.6 0.5 -0.0 0.3 1.1 1.0 0.5 0.5
Pulse rate 0.4 0.7 1.1 -0.7 -0.8 -0.9 -0.7 1.0 -0.7 -1.0 0.7 -0.7 -0.8 -0.8
Happiness 0.1 0.2 0.5 -0.2 0.2 0.5 0.4 -0.6 0.5 0.2 0.3 0.7 0.1 0.1
Noisy workplace 0.2 0.3 0.8 0.0 0.1 0.9 0.8 -0.2 0.5 0.1 -0.5 0.8 0.5 0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.4 2.1 0.2 -0.5 -0.7 -0.8 -0.8 -0.5 1.5 0.0 0.0 -0.6 0.4
Serious illness, injury or assault of a close relative in last 2 years 2.5 2.9 5.7 -0.8 -2.2 -2.3 -2.4 -0.2 -2.0 -0.7 -0.4 -2.2 -2.1 -1.1
Mouth/teeth dental problems: Dentures 0.5 0.8 2.9 -0.5 0.1 -0.9 -0.9 0.9 -0.9 -1.0 0.0 -1.1 -0.7 -1.7
Asthma 0.2 0.4 1.5 -0.2 1.2 0.3 0.5 0.1 0.2 -0.6 0.9 0.5 0.3 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.2 5.8 1.1 -1.2 -0.5 -0.8 -1.9 -1.3 -2.0 -2.4 -0.9 -1.7 -1.5
Medication: Cholesterol lowering 0.2 0.3 0.9 0.7 0.1 0.7 0.6 -0.9 0.3 -0.1 -0.6 0.3 0.4 0.9
Depression (self-reported) 0.7 0.8 2.9 -0.5 1.7 1.1 1.0 0.0 0.9 -0.3 0.2 1.4 0.6 -0.6
Medication: Lansoprazole 1.5 1.7 3.4 0.5 -1.1 -1.9 -1.8 0.1 -1.7 -1.0 0.1 -1.7 -1.7 -0.7
Prospective memory result 1.0 1.3 3.3 0.9 -0.7 -1.1 -1.0 0.7 -1.2 -1.4 -0.6 -1.5 -1.1 -1.8
Lung cancer (father) 1.2 1.4 3.9 -1.2 0.7 0.5 0.7 2.0 0.4 1.6 1.5 0.9 1.3 0.8
Illnesses of mother 0.6 0.8 1.9 0.2 0.2 1.4 1.3 -1.1 0.8 -0.5 -1.1 0.9 0.8 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.2 -0.1 0.8 0.8 1.0 0.2 0.2 -0.1 0.4 1.1 0.5 0.2
Pulse wave Arterial Stiffness index 1.6 1.9 4.2 0.7 1.1 1.8 1.6 -1.4 1.5 0.6 -0.4 1.6 1.2 2.1
Impedance of arm (left) 0.7 3.2 7.2 1.3 0.2 2.7 2.5 -1.9 1.9 0.7 -1.2 2.0 1.9 1.7
Arm fat mass (right) 0.2 0.7 2.4 -0.5 -0.5 -1.3 -1.4 0.1 -0.4 -0.2 0.3 -1.6 -0.7 0.1
Trunk predicted mass 0.6 3.6 7.3 -1.8 -1.1 -2.7 -2.6 0.8 -2.5 -1.1 0.8 -2.4 -2.2 -1.5
Standing height 0.2 1.7 4.5 -1.8 -0.7 -1.5 -1.4 0.0 -2.1 -1.1 0.5 -1.3 -1.5 -0.9
Length of working week for main job 0.9 1.0 2.3 0.9 -1.0 -1.2 -1.3 -0.9 -0.4 0.6 -0.6 -1.1 -0.8 1.5
Exposure to tobacco smoke at home 0.3 0.3 1.3 0.5 0.5 -0.3 -0.4 -0.8 0.1 0.6 -0.2 -0.2 -0.1 1.1
Breastfed as a baby 1.8 2.2 4.9 -0.8 -1.9 -2.0 -2.1 0.1 -1.9 -0.6 0.2 -2.2 -1.5 -0.1
Tense / ‘highly strung’ 0.3 0.4 1.0 1.0 -0.6 -0.8 -1.0 -0.1 -0.6 0.1 -0.5 -0.6 -0.8 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.9 0.2 1.4 0.2 0.4 0.3 0.6 -0.4 0.6 0.8 -0.0 -0.8
Hair/balding pattern: Pattern 4 0.4 1.1 4.3 -2.1 0.0 -0.8 -0.8 0.4 0.0 1.6 1.1 -0.4 0.2 1.6
Birth weight of first child 0.1 0.3 0.8 0.5 -0.5 0.5 0.4 -0.7 0.4 -0.0 -0.9 0.6 0.1 -0.1
Peak expiratory flow (PEF) 0.1 0.2 1.0 0.7 0.3 -0.2 -0.0 0.3 -1.0 -0.6 0.4 0.2 -0.4 0.0
Pulse wave reflection index 1.8 2.2 6.9 0.7 1.0 1.6 1.4 -1.3 1.7 1.5 -0.6 1.4 1.5 2.6
Ever highly irritable/argumentative for 2 days 1.1 1.3 4.2 -2.1 0.7 0.1 0.4 2.0 0.7 0.3 1.9 0.9 0.4 -0.3
Loud music exposure frequency 0.7 0.8 3.8 -0.7 0.4 -0.6 -0.3 2.0 -0.4 -0.6 1.3 -0.4 0.0 -1.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.2 -0.2 0.3 0.3 0.3 0.0 1.3 1.5 0.4 0.7 0.8 1.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.7 0.1 -0.0 0.3 0.6 0.8 -0.0 -0.7 0.2 0.4 0.2 -0.6
Blood clot in the leg (DVT) 0.5 0.6 1.2 -0.8 0.6 1.0 1.1 0.7 1.1 -0.8 0.2 0.8 0.7 -0.4
Medication: Paracetamol 0.1 0.1 0.4 0.4 -0.6 -0.0 -0.1 -0.0 0.3 0.1 -0.6 -0.0 -0.1 -0.4
Headache pain in last month 0.2 0.4 1.6 -0.4 0.6 0.4 0.7 1.3 -0.1 -0.4 0.5 0.5 0.6 0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.7 -0.8 0.2 0.2 0.3 0.4 0.5 0.1 0.2 0.4 0.2 -0.4
Glaucoma (self-reported) 2.5 2.9 12.2 -0.1 -3.5 -1.7 -2.0 -0.7 -1.4 -0.4 -1.3 -2.1 -1.8 -0.9
Gout (self-reported) 0.3 0.5 2.4 0.7 -0.3 0.7 0.6 -1.6 0.6 0.3 -0.2 0.7 -0.0 0.3
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.7 -1.8 0.8 -0.0 0.2 1.9 0.5 1.7 1.9 0.8 0.8 1.4
Medication: Amlodipine 0.2 0.3 1.2 1.1 -0.2 -0.5 -0.6 -0.8 -0.1 0.4 -0.1 -0.2 -0.4 0.6
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.5 -0.2 0.2 0.5 0.6 -0.7 0.3 -0.7 -0.6 0.6 -0.0 -0.0
Birth weight 0.1 0.3 1.2 -0.2 -0.4 -0.2 -0.1 1.1 -0.7 -0.3 -0.7 -0.2 -0.2 -0.6
Chronic bronchitis/emphysema (mother) 0.2 0.2 1.3 -0.3 0.7 -0.3 -0.2 0.6 -0.0 0.3 1.1 -0.0 0.1 0.3
High blood pressure (siblings) 1.3 1.9 4.0 1.1 1.5 1.4 1.3 -0.9 2.0 1.1 0.3 1.5 1.3 1.9
Forced vital capacity (FVC), Best measure 0.1 0.4 1.2 -0.6 0.7 0.6 0.8 0.4 -0.1 -0.1 0.6 1.1 0.3 -0.4
Body fat percentage 0.1 0.2 0.8 0.5 -0.3 -0.5 -0.7 -0.4 0.2 0.0 -0.2 -0.9 -0.3 0.7
Leg fat percentage (right) 0.1 0.4 0.8 -0.1 0.4 -0.9 -0.9 0.6 0.1 0.5 0.8 -0.8 -0.1 0.8
Arm fat-free mass (right) 0.7 3.5 7.5 -1.4 -1.0 -2.7 -2.6 0.9 -2.4 -0.9 0.7 -2.4 -2.2 -1.6
Exposure to tobacco smoke outside home 2.2 2.9 6.9 2.2 2.6 2.2 2.2 -1.2 1.5 -0.5 -1.7 1.4 1.5 0.4
Comparative body size at age 10 0.5 1.5 4.0 1.5 1.4 1.6 1.3 -2.0 1.0 0.1 -1.0 0.9 0.9 0.3
Number of full brothers 1.2 1.5 2.7 -0.3 1.2 1.2 1.2 0.3 1.5 1.4 1.6 1.6 1.4 1.0
Worry too long after embarrassment 0.5 0.9 2.0 0.1 1.3 1.3 1.3 0.1 1.4 -0.4 0.1 1.1 0.9 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.9 0.0 1.4 0.3 0.5 1.1 0.6 0.5 0.8 0.8 0.6 -0.8
Wheeze or whistling in the chest in last year 0.1 0.2 0.7 0.4 0.8 0.1 0.2 0.5 0.2 0.1 0.8 0.3 0.3 -0.5
Number of children fathered 1.0 1.1 2.1 1.4 1.4 1.2 1.1 -0.1 1.5 0.7 0.3 1.1 1.1 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 4.5 2.1 -0.3 0.6 0.5 -1.1 -0.5 -1.3 -1.3 0.1 -0.6 -0.8
Age at first live birth 0.5 1.0 2.3 0.2 -1.0 -1.3 -1.5 -1.2 -0.7 0.1 -0.6 -1.2 -1.3 0.3
Pulse wave peak to peak time 1.6 1.9 4.8 -0.6 -1.1 -1.7 -1.6 1.2 -1.6 -0.7 0.3 -1.6 -1.3 -2.2
Health satisfaction 0.6 0.8 2.4 -1.3 0.2 -0.7 -0.5 1.4 0.9 0.9 1.6 0.3 -0.0 -0.3
Shortness of breath walking on level ground 0.4 0.5 2.4 -1.6 1.3 0.1 0.2 0.5 0.8 -0.4 0.5 0.5 0.1 -0.6
Qualifications: College or University degree 0.4 1.1 2.7 -0.6 -1.5 -0.7 -1.0 -1.4 -0.7 1.6 -0.5 -0.5 -0.4 1.6
Eye problems/disorders: None of the above 0.6 0.7 3.0 1.7 -0.4 -0.0 -0.2 -0.9 -1.5 -0.5 -0.8 -0.1 -0.8 -0.5
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.2 1.5 0.5 0.1 0.2 0.0 -0.4 -1.5 -0.8 0.1 -0.5 -1.1
Emphysema/chronic bronchitis 2.2 2.5 5.0 0.1 2.1 1.6 1.5 -0.4 2.2 2.2 -0.2 2.1 1.6 1.3
Medication for pain relief, constipation, heartburn 0.2 0.3 1.2 -0.9 0.0 -0.5 -0.2 0.8 0.0 0.4 1.1 -0.1 0.1 0.6
Neck or shoulder pain in last month 0.4 0.6 2.5 -1.6 1.0 0.6 0.9 0.7 0.1 -0.8 0.1 0.7 0.5 -0.5
Medication: Blood pressure 0.2 0.4 1.1 0.9 -0.1 -0.8 -0.9 -0.3 -1.1 0.1 -0.1 -0.6 -0.7 0.1
Angina (self-reported) 0.3 0.4 1.8 -0.1 0.7 -0.4 -0.3 1.4 -0.6 -0.1 0.8 -0.2 -0.1 -0.9
Migraine (self-reported) 0.6 0.8 1.9 -0.8 1.4 0.7 0.9 0.9 0.6 0.5 0.8 1.0 0.9 0.8
Medication: Ibuprofen 1.7 2.0 3.4 0.2 -1.5 -1.1 -1.3 -1.3 -1.6 -1.7 -1.8 -1.4 -1.8 -1.3
Medication: Allopurinol 0.7 1.0 3.1 1.8 -0.7 0.7 0.6 -1.7 0.7 -0.4 -1.4 0.5 -0.5 -0.5
Medication: Omeprazole 2.2 2.6 5.6 -1.3 1.7 0.8 1.1 2.3 1.7 1.5 2.4 1.4 1.9 1.1
Medication: Seretide 50 evohaler 0.4 0.4 1.0 1.0 0.8 0.7 0.8 -0.7 0.4 -0.3 -0.6 0.8 0.1 -0.1
Mean time to correctly identify matches 0.2 0.4 1.6 -1.0 0.4 -0.3 -0.1 1.2 0.3 0.2 1.3 0.0 0.2 -0.1
Heart disease (mother) 1.4 1.8 3.9 -1.4 1.1 0.6 0.7 1.3 1.1 1.5 1.8 0.9 1.5 2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 4.3 -0.5 0.7 0.2 0.3 0.0 0.4 0.9 0.7 0.1 0.8 2.1
Whole body fat mass 0.2 0.9 3.1 -0.1 -0.6 -1.6 -1.6 -0.1 -0.8 -0.4 0.1 -1.7 -1.1 0.1
Leg fat mass (right) 0.3 1.2 3.3 -0.5 -0.2 -1.8 -1.7 0.9 -0.9 -0.2 0.9 -1.7 -0.9 0.0
Arm predicted mass (right) 0.9 4.5 9.8 -1.6 -1.2 -3.1 -3.0 1.1 -2.7 -1.0 0.8 -2.8 -2.5 -1.9
Pulse rate, automated reading 0.7 2.2 4.8 -1.1 -1.8 -2.2 -2.0 1.3 -1.1 -0.7 0.6 -1.9 -1.5 -1.1
Alcohol intake frequency. 0.5 1.2 6.9 -2.6 0.4 -0.7 -0.4 1.4 -0.5 -0.5 1.5 -0.6 -0.1 -0.7
Comparative height size at age 10 0.6 3.1 6.6 -1.7 -1.3 -2.0 -1.8 0.5 -2.6 -1.8 0.1 -1.8 -2.0 -2.1
Number of full sisters 0.1 0.2 0.7 -0.2 0.2 -0.2 -0.1 0.1 -0.7 -0.4 0.2 -0.4 -0.1 0.8
Suffer from ‘nerves’ 0.2 0.3 1.0 0.4 0.7 0.8 0.7 -0.7 0.7 -0.2 -0.2 1.0 0.2 -0.2
Overall health rating 0.2 0.3 0.9 -0.6 -0.4 -0.3 -0.4 0.3 -0.8 -0.8 0.4 -0.5 -0.5 -1.0
Chest pain or discomfort 2.1 3.0 6.4 0.8 2.2 2.5 2.5 0.5 1.9 0.2 0.7 2.2 2.3 0.8
Had major operations 1.0 1.2 3.4 0.6 -1.6 -1.8 -1.8 0.3 -0.1 0.4 -0.0 -1.1 -1.4 0.0
Age at last live birth 0.3 0.4 0.8 0.1 -0.7 -0.8 -0.8 -0.8 -0.3 -0.2 -0.8 -0.9 -0.9 0.3
Family relationship satisfaction 0.2 0.3 0.7 0.9 0.6 0.6 0.6 -0.4 0.2 -0.3 0.4 0.7 0.0 -0.8
Leg pain on walking 1.2 1.5 5.3 -1.3 -0.6 -1.6 -1.3 2.3 -0.2 -0.3 1.8 -0.9 -0.6 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.9 0.7 0.9 0.7 0.9 0.4 0.2 0.2 0.2 0.8 0.9 0.6
Commuting to job workplace: Car/motor vehicle 1.4 1.6 4.9 0.1 0.6 0.4 0.5 0.7 1.3 2.2 1.5 1.3 1.0 2.2
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.7 1.4 -1.4 0.3 0.0 -1.6 -1.2 -0.6 -1.3 -0.3 -0.6 -0.7
Medication: Aspirin 1.5 2.0 4.2 0.8 2.0 2.0 2.0 -0.6 1.4 0.6 -0.2 1.7 1.7 1.0
Supplements: Vitamin C 0.7 0.8 4.4 -2.1 0.1 -0.4 -0.0 1.8 -0.3 -0.6 0.5 -0.3 0.1 0.5
Knee pain experienced in last month 0.1 0.1 0.5 0.4 -0.2 0.1 -0.1 0.5 0.4 0.2 0.4 -0.4 0.7 0.4
Hypertension (Self-reported) 0.2 0.5 2.8 0.4 0.5 -0.0 -0.1 -0.3 -0.1 1.0 0.8 0.3 0.2 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 5.4 -1.3 1.4 -0.5 -0.2 2.3 -0.3 0.3 2.1 0.3 0.3 -0.6
Illnesses of father: Heart disease 0.1 0.2 0.7 0.1 -0.6 -0.1 -0.2 0.1 -0.7 -0.4 -0.8 -0.5 -0.3 -0.2
Illnesses of siblings: Diabetes 0.1 0.2 1.0 0.5 -0.3 0.2 -0.0 -1.0 -0.4 0.2 -0.3 0.1 -0.3 0.2
Smoking status: Previous 0.1 0.2 0.9 -0.2 0.4 0.1 0.1 -0.1 -0.4 -1.0 -0.2 0.1 -0.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.2 0.0 -0.1 1.1 0.8 -0.6 0.2 1.0 -0.1 0.9 0.8 0.6
Whole body fat-free mass 0.7 3.9 7.4 -1.2 -1.3 -2.7 -2.6 0.4 -2.7 -1.5 0.3 -2.7 -2.4 -1.8
Leg fat-free mass (right) 0.6 3.2 6.9 -0.4 -1.6 -2.1 -2.2 -0.4 -2.4 -1.7 -0.6 -2.6 -2.2 -1.6
Arm fat percentage (left) 0.1 0.3 0.7 0.7 -0.3 -0.1 -0.3 -0.8 0.5 0.0 -0.5 -0.7 0.1 0.8
Average weekly red wine intake 0.4 0.6 2.5 1.6 0.0 -0.5 -0.6 -1.0 0.3 1.0 0.0 -0.4 0.0 1.3
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.8 0.9 -0.6 -0.7 -0.8 -1.7 -1.1 -1.9 -1.7 -1.0 -1.6 -1.5
Mood swings 1.8 3.3 7.2 2.6 1.5 2.5 2.2 -2.7 0.9 -1.0 -2.1 1.5 0.9 0.2
Loneliness, isolation 0.6 0.8 3.6 0.5 1.2 0.7 0.9 0.6 -0.2 -1.2 0.4 0.8 0.0 -1.9
Long-standing illness, disability or infirmity 1.1 1.7 4.1 -0.9 -1.1 -1.4 -1.4 0.8 -2.0 -1.5 0.7 -1.6 -1.3 -1.2
Ever had bowel cancer screening 0.4 0.5 1.1 -0.9 0.2 -0.8 -0.7 0.4 -1.0 -0.5 1.1 -0.6 -0.6 -0.4
Diabetes diagnosed by doctor 0.9 1.5 3.6 1.6 1.4 1.9 1.9 -1.3 0.4 -0.5 -0.7 1.1 1.0 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.7 0.2 -0.4 -1.3 -1.3 -0.3 -0.5 -0.4 -0.1 -1.1 -1.2 -0.4
Friendships satisfaction 0.4 0.5 1.0 -0.6 -0.8 -0.9 -1.0 0.7 -0.4 0.1 0.9 -0.4 -0.7 -0.4
Qualifications: nursing, teaching 0.3 0.5 2.4 0.2 -0.1 -0.6 -0.5 0.9 -0.2 0.8 1.6 -0.5 0.3 1.0
Commuting to job workplace: Walk 2.3 2.5 7.0 1.1 -1.1 -0.5 -0.6 -1.0 -1.9 -2.6 -2.0 -1.3 -1.5 -2.1
Eye problems/disorders: Cataract 0.7 0.8 2.8 -1.0 0.9 1.0 1.1 0.1 1.7 0.4 0.2 0.6 1.2 0.3
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 8.9 -1.2 -0.5 -1.3 -1.0 1.5 -0.9 -2.2 0.4 -1.0 -1.6 -3.0
Medication for cholesterol 0.4 0.6 2.4 0.5 -0.4 -0.3 -0.3 -0.5 -0.2 -1.5 -1.2 -0.8 -0.6 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 2.0 0.2 -0.8 -1.4 -1.4 0.2 -0.5 -0.6 -0.2 -1.4 -1.2 -0.9
Back pain experienced in last month 0.0 0.1 0.3 0.1 -0.5 -0.1 -0.2 0.4 -0.2 -0.0 -0.1 -0.3 -0.1 0.2
Mineral and other dietary supplements 0.8 1.0 2.7 -0.6 -1.0 -1.6 -1.5 0.9 -0.7 0.1 0.9 -1.4 -0.8 -0.5
Breast cancer (self-reported) 0.8 1.0 2.4 -1.3 -1.2 -1.3 -1.5 0.0 -0.6 0.8 -0.1 -1.2 -0.9 -0.5
Asthma (self-reported) 0.2 0.4 1.5 -0.5 1.2 0.3 0.6 0.4 0.3 -0.4 1.1 0.5 0.4 -0.7
Osteoporosis (self-reported) 0.4 0.5 2.1 -0.1 -0.7 0.2 -0.0 -1.2 -0.5 -0.7 -1.4 -0.1 -0.6 -0.7
Osteoarthritis (self-reported) 0.3 0.4 1.2 0.5 -0.1 0.9 0.4 -1.0 0.2 -0.6 -1.1 0.1 0.2 -0.7
Medication: Aspirin 1.0 1.3 2.7 0.1 1.6 1.3 1.3 0.3 1.3 1.0 0.3 1.1 1.6 1.2
Medication: Gliclazide 2.6 2.9 6.2 2.2 1.4 2.5 2.3 -2.3 1.2 -0.4 -1.3 1.9 1.2 0.5
Illnesses of father: None of the above (group 1) 0.7 0.8 2.6 0.4 -1.6 -1.0 -1.0 -0.0 -0.7 -0.8 -0.1 -1.2 -0.9 -0.8
Smoking status: Current 1.3 2.0 7.4 1.2 -0.6 0.1 0.1 -0.5 -1.4 -2.1 -2.1 -0.4 -1.2 -2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 3.9 0.5 2.0 1.2 1.5 1.0 1.6 1.2 1.5 1.5 1.6 1.2
Whole body water mass 0.7 3.9 7.4 -1.3 -1.3 -2.7 -2.7 0.5 -2.6 -1.4 0.4 -2.7 -2.4 -1.8
Leg predicted mass (right) 0.6 3.2 6.8 -0.4 -1.5 -2.1 -2.2 -0.4 -2.3 -1.7 -0.6 -2.6 -2.2 -1.6
Arm fat mass (left) 0.1 0.6 2.3 -0.2 -0.4 -1.2 -1.2 0.0 -0.4 -0.5 0.0 -1.5 -0.7 -0.1
Number of self-reported non-cancer illnesses 0.5 0.8 2.4 0.1 0.8 0.7 0.6 0.3 0.6 1.6 1.1 1.0 1.1 1.3
Average weekly champagne plus white wine intake 0.5 0.7 2.5 1.6 -0.7 -0.6 -0.8 -1.0 -0.6 -0.5 -0.8 -0.5 -1.1 -0.2
Miserableness 0.6 1.0 2.1 1.2 0.8 1.4 1.3 -1.1 1.3 0.0 -0.6 1.2 0.8 0.4
Guilty feelings 0.9 1.4 2.6 0.6 1.3 1.6 1.6 0.8 1.5 0.2 0.7 1.4 1.5 0.2
Wears glasses or contact lenses 0.4 0.4 1.6 -0.4 1.0 0.3 0.5 1.3 0.1 0.1 0.9 0.7 0.5 0.2
Ever taken oral contraceptive pill 1.4 1.6 4.9 -1.1 0.8 -0.1 0.3 2.0 0.8 1.6 2.2 0.6 1.1 1.5
Hearing aid user 0.8 0.9 2.0 -1.4 0.6 1.1 1.1 0.2 1.1 0.7 0.0 1.0 1.2 1.1
Mother’s age at death 0.5 0.6 1.3 0.9 -1.1 -0.5 -0.9 -0.9 -0.7 0.4 -0.7 -0.8 -0.7 0.2
Financial situation satisfaction 0.8 1.0 3.3 -1.3 1.8 1.1 1.3 0.1 1.0 -0.2 -0.0 1.2 0.8 -0.4
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.1 0.7 -0.4 0.2 0.1 -0.7 1.0 0.2 0.2 0.4 0.2 0.7
Commuting to job workplace: Public transport 5.2 6.2 11.1 0.0 -1.9 -2.9 -2.9 -0.9 -3.2 -2.8 -0.8 -3.0 -3.3 -3.0
Eye problems/disorders: Glaucoma 2.8 3.3 11.5 -0.1 -3.4 -2.0 -2.3 -0.7 -1.5 -0.8 -1.0 -2.5 -2.0 -0.7
Medication: Blood pressure 0.3 0.6 2.6 -0.3 0.6 -0.2 -0.2 -0.0 0.3 1.3 1.2 0.3 0.4 1.6
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 -0.2 -0.6 -0.4 -0.4 0.4 -0.4 0.2 0.4 -0.3 -0.2 -0.5
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.2 0.8 0.9 1.5 1.5 -1.0 0.7 -0.9 -1.3 1.1 0.4 -0.5
High cholesterol (Self-reported) 0.2 0.3 1.5 0.4 0.4 0.5 0.3 -1.2 0.2 -0.4 -0.7 -0.0 -0.0 0.4
Medication: Bendroflumethiazide 0.4 0.6 2.1 -0.7 0.6 -0.2 -0.0 1.2 -0.1 0.9 1.2 0.2 0.5 1.4
Medication: Paracetamol 0.1 0.1 0.4 -0.5 -0.3 -0.2 -0.3 0.1 0.6 0.2 -0.1 -0.1 -0.2 -0.3
Medication: Lisinopril 0.4 0.5 2.5 0.3 0.3 -0.3 -0.3 -1.0 -0.4 0.9 -0.5 -0.3 -0.1 1.6
Medication: Atorvastatin 0.6 0.7 1.6 0.6 0.8 1.1 1.1 -0.7 0.6 0.7 -0.1 1.3 0.8 1.0
Illnesses of father: High blood pressure 0.7 0.9 3.1 0.1 1.3 0.6 0.8 0.3 0.5 0.7 0.9 1.0 0.9 1.8
Alcohol drinker status: Never 2.4 2.8 5.2 0.6 -1.8 -1.8 -2.0 -1.2 -1.9 -1.4 -1.1 -2.1 -2.3 -1.7
Ever smoked 1.1 1.9 5.4 -0.1 -0.2 -0.8 -0.6 0.3 -2.3 -2.2 -1.2 -1.0 -1.4 -2.3
Basal metabolic rate 0.6 3.2 6.4 -1.2 -1.1 -2.5 -2.4 0.4 -2.3 -1.3 0.4 -2.5 -2.1 -1.5
Leg fat percentage (left) 0.1 0.4 1.1 -0.1 0.6 -0.7 -0.6 0.6 0.3 0.5 0.8 -0.5 0.1 1.1
Arm fat-free mass (left) 0.8 3.9 8.3 -1.8 -0.8 -2.9 -2.7 1.2 -2.3 -1.0 1.0 -2.6 -2.2 -1.9
Number of operations (self-reported) 2.0 2.9 7.1 -0.4 -2.2 -2.5 -2.7 0.3 -1.6 -0.2 -0.6 -2.1 -2.2 -1.2
Average weekly beer plus cider intake 0.2 0.3 1.4 0.4 0.2 0.2 0.4 0.3 -0.6 -1.2 -0.3 -0.1 -0.1 -1.1
Irritability 0.5 0.9 3.1 1.7 1.8 0.5 0.3 -1.3 0.6 0.4 -0.4 0.7 0.2 0.6
Risk taking 0.5 0.7 2.8 1.4 0.5 0.8 0.7 -0.7 0.0 -1.2 -1.7 0.3 -0.0 -0.1
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.6 1.0 -1.6 -1.4 -1.6 -0.7 -1.4 0.5 -0.8 -1.2 -1.3 -0.2
Fractured/broken bones in last 5 years 0.7 0.9 4.7 -0.2 0.1 -0.2 -0.2 -0.4 -0.6 -1.5 -1.2 -0.3 -0.9 -2.2
Age started oral contraceptive pill 0.5 0.7 3.4 1.4 -0.5 -0.0 -0.3 -1.8 0.2 -0.7 -0.8 -0.2 -0.6 -0.4
Diastolic blood pressure, automated reading 0.2 0.7 1.4 1.0 -0.9 -0.6 -0.8 -0.9 -0.4 -0.7 -1.2 -1.0 -0.9 0.3
Ever depressed for a whole week 0.8 1.0 4.4 -1.1 0.7 -0.2 0.2 2.0 0.2 0.2 2.1 0.7 0.3 0.6
Unable to work because of sickness or disability 1.5 1.9 4.6 0.6 1.5 1.3 1.7 0.8 1.2 -2.1 0.4 1.5 0.5 -2.1
Commuting to job workplace: Cycle 0.2 0.3 1.2 -0.3 -0.7 0.1 -0.0 -0.3 0.8 1.1 0.0 -0.1 0.3 0.5
Myopia 0.7 1.0 3.0 1.6 -0.6 -0.1 -0.3 -1.1 -0.6 -1.4 -0.7 -0.3 -1.0 -1.7
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.9 -0.3 -0.9 0.1 0.2 -0.0 0.1 -0.8 -0.7 -0.2 -0.1 -0.9
Cholesterol lowering medication 0.2 0.3 2.1 -1.4 0.2 0.1 0.3 0.3 0.3 0.4 0.7 0.2 0.3 0.2
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 5.0 -1.3 1.9 0.7 1.1 2.2 1.3 1.4 2.2 1.4 1.7 1.1
Pain experienced in last month 0.1 0.2 1.0 0.4 0.6 -0.1 0.1 0.1 0.5 -0.7 -0.4 -0.0 -0.3 -1.0
Supplements: Calcium 0.3 0.3 1.4 -0.2 0.3 0.5 0.6 -0.1 -0.3 -1.2 -0.4 0.3 -0.1 -0.7
Basal cell carcinoma (self-reported) 0.4 0.4 1.5 -1.2 0.8 0.1 0.2 -0.0 0.1 0.8 0.5 0.4 0.3 1.1
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.4 0.8 -0.6 -0.0 -0.3 -0.8 -0.3 -0.0 -1.2 -0.3 -0.5 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.3 -1.1 0.4 0.5 0.6 0.8 0.6 -1.1 0.2 0.4 0.3 -0.7
Heart disease (siblings) 0.7 0.8 3.5 1.4 0.3 0.5 0.3 -1.9 0.2 -1.0 -1.3 0.0 -0.4 0.0
Alcohol drinker status: Previous 0.2 0.2 0.8 -0.0 0.1 0.4 0.2 -0.8 0.9 0.0 -0.1 0.3 0.2 0.6
Pack years of smoking 0.4 0.6 2.3 0.9 -0.2 0.2 0.1 -0.4 -0.9 -1.5 -1.2 -0.7 -0.3 -0.9
Impedance of whole body 0.4 2.0 4.5 0.4 0.5 2.1 2.1 -0.8 1.7 0.9 -0.4 2.1 1.7 1.2
Leg fat mass (left) 0.2 0.9 2.6 -0.5 -0.1 -1.6 -1.5 0.8 -0.7 -0.2 0.8 -1.5 -0.8 0.1
Arm predicted mass (left) 0.6 3.3 7.2 -1.6 -0.8 -2.7 -2.6 1.1 -2.1 -0.6 1.1 -2.4 -1.9 -1.5