Hub : Genes

MLC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0520	0.0190	7.6e-04	0.007	0.022	0.012	0.02	0.009	4.2e-02	8.2e-04	1.2e-02	0.0016	2.6e-02
2	TCGA	Bladder Urothelial Carcinoma	0.0670	0.0320	6.7e-04	0.048	0.062	0.056	NA	0.046	5.8e-05	6.3e-06	1.7e-05	NA	8.2e-05
3	TCGA	Breast Invasive Carcinoma	0.1183	0.0302	0.0e+00	0.116	0.107	0.109	NA	0.113	8.4e-23	4.9e-21	2.0e-21	NA	2.5e-22
4	TCGA	Cervical Squamous Cell Carcinoma	0.2830	0.0770	1.5e-07	0.185	0.133	0.174	NA	0.179	1.9e-09	4.7e-07	5.9e-09	NA	3.5e-09
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0335	0.0165	2.0e-03	0.018	0.026	0.000	NA	0.012	3.2e-03	6.2e-04	3.3e-01	NA	1.4e-02
6	TCGA	Lung Adenocarcinoma	0.1209	0.0446	7.6e-09	0.039	0.068	0.073	NA	0.068	2.0e-05	2.4e-08	7.2e-09	NA	2.0e-08
7	TCGA	Lung Squamous Cell Carcinoma	0.0394	0.0185	2.8e-04	0.043	0.032	0.038	NA	0.045	1.1e-05	1.3e-04	3.2e-05	NA	6.9e-06
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.1340	0.0580	6.4e-05	0.024	0.055	0.042	NA	0.027	9.4e-03	1.4e-04	8.0e-04	NA	6.0e-03
9	TCGA	Pancreatic Adenocarcinoma	0.2150	0.0690	2.0e-07	0.149	0.156	0.188	NA	0.192	8.4e-07	4.2e-07	2.4e-08	NA	1.7e-08
10	TCGA	Prostate Adenocarcinoma	0.0931	0.0322	6.9e-10	0.065	0.096	0.093	NA	0.110	2.2e-07	3.1e-10	5.8e-10	NA	1.3e-11
11	TCGA	Rectum Adenocarcinoma	0.2350	0.0970	1.6e-03	0.180	0.042	0.089	NA	0.025	5.3e-05	3.8e-02	4.1e-03	NA	8.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.1	0.2	0.4	-0.4	0.5	0.4	0.2	-0.7	0.4	0.5	-0.4	0.0	0.4	0.5
Bipolar Disorder or Schizophrenia	0.7	1.7	5.0	-0.2	2.2	1.5	1.6	0.6	1.3	0.5	0.7	1.4	1.8	1.0
Depressed Affect (Nagel 2018)	1.3	2.7	6.4	2.5	1.4	1.9	1.6	-2.4	0.6	-1.9	-1.9	0.9	0.2	-0.6
Depression (Nagel 2018)	0.6	0.8	2.7	-0.0	0.4	1.4	1.2	-0.9	1.6	-0.3	-0.7	0.9	0.7	0.4
Intelligence (Savage-Jansen 2018)	1.4	4.3	10.4	0.6	-1.2	-3.0	-3.0	0.4	-3.2	-0.7	-0.0	-2.5	-2.5	-2.0
Neuroticism (Nagel 2018)	1.0	2.4	5.2	2.3	1.6	2.2	1.9	-1.6	1.5	-0.6	-1.3	1.5	0.9	-0.4
Schizophrenia (2018)	1.1	2.3	6.0	0.0	2.4	1.6	1.9	1.2	1.4	0.2	1.2	1.7	2.0	1.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-0.0	0.1	0.5	0.7	0.8	0.6	0.1	1.0	1.0	0.6	0.3
Worry (Nagel 2018)	0.8	1.6	3.4	1.6	1.4	1.6	1.3	-1.2	1.8	0.5	-0.3	1.5	1.1	0.4
Alzheimer’s Disease (in mother)	1.2	1.4	7.2	-1.5	0.9	-1.0	-0.5	2.7	-0.3	0.1	1.6	-0.3	-0.1	-1.0
Alzheimer’s Disease (in father)	0.9	0.9	2.3	-0.1	-0.8	-1.4	-1.5	0.2	-1.2	0.0	-0.5	-1.4	-1.0	-0.7
Alzheimer’s Disease (including proxy)	0.8	1.2	2.8	-1.0	0.2	-1.5	-1.3	1.7	-1.0	-0.2	0.4	-1.1	-1.0	-1.4
Crohns Disease (2017)	0.2	0.4	1.3	-0.4	-0.1	-0.5	-0.8	-1.0	0.4	1.2	0.1	-0.4	-0.1	0.5
Irritable Bowel Disease (IBD)	0.4	0.9	3.1	0.4	1.0	1.0	0.8	-1.8	1.4	0.5	-0.2	0.7	0.6	0.7
Ulcerative Colitis (UC)	1.1	2.1	4.3	0.6	1.7	2.0	1.9	-1.7	2.1	0.2	0.0	1.5	1.3	1.1
Major Depression (MDD)	0.2	0.3	1.6	0.0	0.0	0.3	0.5	0.0	0.0	0.0	0.0	0.9	1.3	0.0
Reaction Time	0.3	0.5	1.8	-1.3	0.6	0.2	0.3	0.8	0.7	0.3	1.4	0.0	0.7	0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.4	0.4	-0.9	-1.6	-1.7	-0.3	-1.8	-0.3	-0.4	-1.1	-1.8	-1.6
Breast Cancer	0.9	2.2	5.5	2.3	1.6	1.9	1.8	-0.7	1.6	0.6	-0.4	1.5	1.5	1.1
Ovarian Cancer	0.3	0.4	1.7	-0.9	-0.5	-0.3	-0.1	0.5	-0.5	-0.8	0.2	-0.2	-0.5	-1.3
Prostate Cancer	0.4	0.6	2.5	-1.6	-1.2	-0.3	-0.3	0.6	0.0	-0.1	0.3	-0.4	-0.2	-1.3
Age at First Birth	1.2	1.7	4.8	2.0	-1.0	-0.6	-0.7	-2.2	-1.3	-0.9	-1.6	-1.0	-1.5	0.1
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.5	0.0	-0.1	-0.1	0.0	0.3	-0.5	-0.1	0.1	0.4
Body Mass Index (BMI) (2010)	0.2	0.2	1.2	1.1	-0.0	0.4	0.3	-0.6	-0.4	-0.5	-0.3	-0.3	0.2	0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.0	0.3	-0.3	-0.5	0.6	0.0	-0.7	0.4	-0.8	-0.1	-0.4
Crohns Disease (2012)	0.1	0.2	1.0	-0.4	-0.3	-0.2	-0.5	-1.0	0.1	0.9	0.1	-0.3	-0.1	0.2
Mean Putamen Volume	0.5	0.6	2.2	-0.0	0.1	-1.0	-0.9	0.2	-0.6	0.5	1.0	-0.9	-0.1	1.5
Fasting Glucose	3.6	4.3	9.5	0.3	2.1	3.0	3.1	-0.3	2.0	1.6	0.4	2.8	2.9	1.2
HbA1C	3.3	3.7	12.0	0.3	2.1	3.0	3.5	-1.0	1.6	-0.4	-1.0	2.8	1.4	0.7
HDL Cholesterol	0.0	0.1	0.2	-0.2	-0.5	-0.2	-0.1	0.5	0.2	0.1	0.2	-0.2	0.1	-0.4
LDL Cholesterol	0.4	0.7	4.6	-2.1	0.1	0.1	0.2	0.7	0.2	0.0	1.0	0.2	0.6	0.9
Lupus	0.1	0.2	0.6	0.0	0.5	0.2	0.1	-0.6	0.1	0.7	-0.1	0.3	0.2	0.8
Neuroticism (2016)	2.2	3.2	5.7	0.3	2.1	2.4	2.4	-0.0	2.0	1.4	0.3	2.4	2.3	1.3
Primary Biliary Cirrhosis	0.5	0.7	1.8	-1.4	0.0	0.7	0.7	0.4	1.0	1.1	0.4	1.3	0.6	0.2
Rheumatoid Arthritis	0.5	0.7	2.8	-0.2	-1.1	0.3	-0.0	-1.7	-0.8	-0.2	-1.6	-0.3	-0.3	-0.1
Schizophrenia (2014)	0.8	1.7	3.9	-0.8	2.0	1.4	1.7	0.9	1.1	0.0	0.9	1.5	1.6	1.1
Triglycerides	0.9	1.5	6.0	-2.5	1.4	0.2	0.4	1.4	0.9	1.2	1.7	0.7	0.8	0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	-0.5	0.6	0.9	0.8	0.7	0.2	0.6	0.7	0.5	1.1	0.0
Ulcerative Colitis	0.5	0.8	2.0	0.5	0.7	1.2	1.2	-1.4	1.4	-0.3	0.0	0.8	0.6	-0.1
Blood Eosinophil Count	1.6	12.6	24.2	-4.1	-1.9	-4.9	-4.2	2.9	-4.0	-2.2	2.0	-4.1	-3.5	-3.6
Blood Platelet Count	2.2	24.9	86.5	-6.8	2.5	-3.6	-2.0	5.4	-3.8	-6.0	4.3	-1.9	-3.9	-9.3
Blood Red Count	0.4	3.4	13.5	-3.7	-0.1	0.0	0.2	0.8	1.3	3.4	1.9	1.1	1.2	2.0
Blood White Count	1.5	11.3	17.6	-1.2	-4.0	-4.2	-4.0	1.0	-4.2	-2.8	-0.7	-4.0	-4.2	-3.6
Heel T-Score	0.8	6.6	36.8	6.1	0.7	1.4	0.9	-3.0	1.6	2.6	-1.4	1.4	1.2	2.9
BMI	0.1	0.4	1.1	0.9	-0.1	-0.7	-0.8	-0.5	0.3	0.2	-0.2	-1.1	-0.3	1.0
Height	0.0	0.8	3.1	-1.8	1.7	0.0	0.3	-0.5	-0.9	-0.8	0.8	-0.1	0.0	0.7
Waist Hip Ratio (WHR)	0.4	2.0	3.6	-1.3	-1.6	-1.5	-1.6	-0.4	-1.2	-1.4	-0.8	-1.9	-1.7	-1.6
Systolic Blood Pressure	0.1	0.4	1.9	0.4	-0.4	0.5	0.2	-0.7	0.5	1.1	-0.2	0.6	0.5	1.4
Smoking Status	0.8	1.8	4.6	1.6	0.5	0.7	0.6	-1.4	-0.7	-2.2	-2.0	0.2	-0.8	-2.1
Allergy or Eczema	0.8	2.2	8.1	-2.9	-0.8	-2.0	-1.7	1.4	-1.0	0.5	1.6	-1.4	-0.8	0.3
Cardiovascular Disease	0.1	0.4	2.3	0.5	-0.2	0.6	0.5	-0.7	-0.3	0.4	-0.1	0.2	0.4	1.5
Hypothyroidism (self reported)	0.6	1.3	4.0	-1.6	0.3	-0.1	0.1	2.0	0.3	1.4	1.8	0.7	0.7	1.1
Respiratory disease	0.3	0.7	2.2	-1.2	1.5	0.4	0.6	0.5	0.5	0.5	1.3	0.8	0.7	-0.1
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.2	1.7	2.0	2.0	1.9	-1.1	1.3	0.8	0.2	1.5	1.7	1.9
Lung FEV1/FVC ratio	0.3	1.6	4.9	1.9	0.7	1.2	0.9	-2.2	0.2	-0.4	-1.6	0.1	0.7	1.9
Lung FVC	0.2	1.0	4.2	-1.6	0.2	-0.6	-0.2	2.1	-0.1	0.8	1.7	0.2	0.2	0.4
Neuroticism	1.7	4.1	8.4	2.9	2.3	2.7	2.3	-2.6	1.7	-0.9	-1.8	1.8	1.2	0.5
Chronotype (morning person)	0.2	0.4	1.0	-0.6	0.2	-1.0	-0.9	0.4	-0.7	0.2	-0.2	-0.6	-0.8	-0.4
Hair Pigment	0.0	0.7	3.3	1.8	-0.3	0.6	0.8	-0.0	0.2	-1.4	-0.6	0.5	-0.0	-1.2
Tanning	0.1	1.2	3.2	-1.8	-0.3	-1.0	-0.8	1.8	-1.0	1.5	0.8	-0.5	0.0	1.0
Hand grip strength (left)	0.6	1.5	5.8	-0.6	1.1	0.0	0.2	0.7	0.8	2.2	1.1	0.8	1.2	2.4
Number of treatments/medications taken	0.4	0.7	1.9	-0.2	1.4	0.8	0.8	0.5	0.9	0.9	0.8	1.1	1.0	0.5
Average weekly spirits intake	0.3	0.3	1.0	-0.4	0.1	0.3	0.3	0.8	1.0	0.5	0.5	0.4	0.7	0.8
Sensitivity / hurt feelings	0.6	1.0	2.0	0.8	1.1	1.3	1.1	-0.1	1.4	1.2	-0.3	1.3	1.1	0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	0.5	0.5	1.1	0.9	-1.3	0.8	-0.1	-0.6	0.4	0.6	0.6
Hearing difficulty/problems: Yes	0.4	0.5	1.8	-0.9	1.3	0.5	0.8	-0.2	-0.1	-0.5	0.4	0.6	0.4	1.2
Relative age of first facial hair	0.3	0.6	2.8	-0.5	0.3	0.0	0.0	-1.1	-0.7	-1.7	-1.0	-0.6	-0.7	-0.6
Other serious medical condition/disability diagnosed by doctor	4.2	5.4	9.3	-0.9	-2.6	-2.8	-2.8	0.5	-3.0	-2.3	-0.6	-3.1	-2.7	-2.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.3	-0.4	0.2	-1.2	-1.1	1.5	-1.1	0.6	1.1	-0.5	-0.6	-0.6
Ever had hysterectomy (womb removed)	0.5	0.6	2.0	1.4	0.5	0.5	0.5	-0.5	-0.1	-1.2	-0.5	0.4	-0.3	-1.1
Systolic blood pressure, automated reading	0.3	1.0	3.0	1.7	-1.1	-0.1	-0.6	-1.6	-0.7	0.1	-1.4	-0.4	-0.6	0.9
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	6.1	0.1	2.5	1.3	1.4	0.4	1.7	1.0	1.0	1.6	1.7	1.3
Angina	0.3	0.4	1.2	0.0	0.4	-0.6	-0.5	1.1	-0.8	-0.2	0.6	-0.5	-0.3	-0.9
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.2	1.2	0.4	0.4	0.6	0.7	1.0	0.7	1.0	0.5	-0.6
Vitamin and mineral supplements	0.5	0.6	2.5	0.1	-1.4	-0.3	-0.7	-1.6	-0.3	0.7	-0.4	-0.7	-0.4	0.7
Supplements: Zinc	0.4	0.5	1.0	-0.1	-0.6	-0.8	-0.4	1.0	-0.7	-0.9	-0.1	-0.4	-0.7	-1.0
Medication: Co-codamol	1.2	1.4	4.8	-1.4	-0.7	-1.7	-1.6	2.2	-0.2	0.4	1.0	-1.1	-0.8	-0.0
Medication: Metformin	1.1	1.5	5.5	2.3	1.0	1.5	1.3	-1.8	0.6	-0.3	-1.1	0.6	0.7	0.0
Diabetes (father)	0.8	1.0	2.0	-0.4	1.4	1.1	1.3	-0.2	1.4	0.0	0.4	1.2	1.0	1.3
Diabetes (mother)	0.6	0.7	3.5	-0.5	0.1	0.7	0.8	0.0	0.6	1.1	0.4	0.7	0.9	1.9
Severe depression (siblings)	0.9	1.1	2.1	-0.9	1.1	0.5	0.6	0.9	0.8	1.4	1.4	1.1	1.0	1.2
Pack years adult smoking proportion	0.8	1.2	4.0	1.0	-0.4	-0.2	-0.2	-0.2	-1.4	-2.0	-1.2	-1.0	-0.7	-1.6
Impedance of leg (right)	0.4	1.7	3.3	-0.9	1.0	1.0	1.2	1.0	1.4	1.7	1.3	1.8	1.6	1.2
Leg fat-free mass (left)	0.7	3.5	7.4	-0.5	-1.6	-2.3	-2.3	-0.3	-2.4	-1.8	-0.4	-2.7	-2.3	-1.7
Trunk fat percentage	0.1	0.3	0.7	0.7	-0.4	-0.4	-0.5	-0.6	0.1	-0.2	-0.5	-0.8	-0.3	0.6
Hand grip strength (right)	0.4	1.2	4.2	-1.0	1.0	0.1	0.3	0.3	0.6	1.9	0.8	1.0	0.8	2.1
Townsend deprivation index at recruitment	0.4	0.5	3.0	0.8	1.1	0.4	0.3	-0.4	-0.0	-0.6	-0.2	-0.0	0.2	-1.7
Current tobacco smoking	1.5	2.5	9.7	1.2	-0.6	-0.0	-0.0	-0.7	-1.6	-2.4	-2.1	-0.6	-1.5	-3.1
Average weekly fortified wine intake	0.9	1.0	2.0	-1.4	-0.5	-1.3	-1.2	1.3	-0.5	-0.2	0.9	-0.9	-0.8	-1.4
Maternal smoking around birth	1.5	2.1	6.9	-1.1	-0.0	-1.5	-1.2	1.7	-0.8	-2.1	0.7	-0.8	-1.6	-2.6
Fed-up feelings	2.1	3.8	8.5	1.2	2.6	2.9	2.9	-1.5	2.0	-0.8	-1.1	2.4	1.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	-1.2	0.9	1.1	1.2	0.4	1.4	-0.7	0.2	1.0	0.7	-0.2
Relative age voice broke	0.6	1.0	3.5	-1.9	0.4	-0.0	0.1	0.7	0.2	1.2	1.8	0.1	0.8	1.1
Taking other prescription medications	0.5	0.7	2.1	-0.6	-0.9	-0.8	-0.9	0.1	-1.4	-0.6	0.1	-0.8	-1.0	-1.1
Age when periods started (menarche)	1.1	2.6	12.9	-3.6	0.9	-0.4	0.1	2.7	0.3	1.4	1.9	0.4	1.1	1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.5	-1.1	1.6	0.9	1.2	0.4	-0.1	-0.2	0.3	1.2	0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.7	1.6	-0.1	-0.7	-0.7	-1.1	-0.3	0.9	0.1	-0.5	-0.2	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	-0.4	1.0	-0.5	-0.3	1.1	0.3	0.5	0.8	-0.2	0.2	0.6
Qualifications: CSEs or equivalent	1.6	2.2	5.2	-0.8	1.4	1.9	2.2	0.9	1.3	0.4	0.3	1.3	2.3	1.7
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-1.0	-0.3	-1.1	-1.1	0.7	-0.3	-0.2	0.7	-1.1	-0.4	-0.3
High blood pressure	0.2	0.5	2.7	0.4	0.9	0.1	0.1	-0.2	0.0	1.1	0.8	0.5	0.3	1.6
Hayfever, allergic rhinitis or eczema	0.8	1.6	8.0	-2.8	0.2	-1.2	-0.8	1.5	-0.1	0.5	2.2	-0.5	-0.1	0.7
Multivitamins +/- minerals	0.3	0.4	2.3	0.4	0.9	-0.2	0.1	1.5	0.0	-0.6	0.4	0.0	0.1	-0.7
Stomach or abdominal pain in last month	0.9	1.1	2.3	0.4	0.9	1.2	1.1	-0.3	1.1	1.0	0.8	0.9	1.5	1.5
Supplements: Glucosamine	1.5	2.0	4.7	1.1	1.1	2.2	2.1	-0.1	1.7	0.6	-0.4	1.9	1.6	0.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.8	-0.7	-1.7	-1.6	-1.5	1.4	-0.4	0.1	0.8	-1.2	-0.8	-0.4
Medication: Atenolol	0.4	0.5	1.2	0.0	1.0	0.8	0.9	0.3	0.7	0.5	0.2	1.1	0.7	0.9
Medication: Levothyroxine sodium	0.5	0.8	3.0	-1.7	0.9	-0.3	-0.0	1.4	0.2	0.8	1.3	0.4	0.4	0.6
Sitting height	0.8	5.7	12.3	0.4	-2.3	-3.0	-3.0	-0.4	-3.5	-1.7	-0.5	-2.6	-3.3	-2.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.5	-1.6	-0.5	-1.0	-0.9	0.6	-0.6	-0.5	0.5	-1.0	-0.5	-0.6
High blood pressure (mother)	0.1	0.2	0.5	0.3	0.1	-0.6	-0.7	-0.0	-0.5	0.6	0.4	-0.5	-0.3	0.5
Body mass index (BMI)	0.1	0.6	2.0	0.0	-0.4	-1.3	-1.3	0.4	-0.5	-0.2	0.2	-1.4	-0.8	-0.0
Impedance of leg (left)	0.4	2.1	4.1	-0.8	1.4	1.2	1.4	0.9	1.7	1.7	1.1	2.0	1.7	1.5
Leg predicted mass (left)	0.7	3.6	7.7	-0.5	-1.6	-2.3	-2.4	-0.3	-2.5	-1.8	-0.3	-2.8	-2.3	-1.7
Trunk fat mass	0.1	0.6	2.0	0.2	-0.6	-1.1	-1.2	-0.3	-0.7	-0.5	-0.2	-1.4	-0.9	0.2
Waist circumference	0.4	1.5	4.1	-0.3	-0.8	-2.0	-1.9	0.3	-0.9	-0.7	0.4	-2.0	-1.4	-0.8
Number of incorrect matches in round	0.2	0.4	1.5	0.9	0.3	-0.0	-0.2	-0.8	0.1	-0.5	-0.9	-0.5	-0.3	-1.2
Past tobacco smoking	0.4	0.8	3.3	0.1	-0.2	0.3	0.2	-0.5	1.1	1.6	0.6	0.5	0.8	1.8
Alcohol usually taken with meals	0.5	0.9	2.5	0.6	-1.5	-0.7	-1.2	-1.6	-0.5	0.7	-0.7	-0.7	-0.8	0.6
Nervous feelings	0.3	0.5	1.7	0.8	0.4	0.7	0.5	-0.6	1.3	0.9	-0.2	0.9	0.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	3.7	5.8	10.9	-0.1	3.3	3.2	3.3	-0.3	3.0	0.9	0.2	3.2	2.9	1.9
Hearing difficulty/problems with background noise	1.4	2.3	4.4	-0.5	1.8	1.8	2.0	0.3	1.2	0.9	1.3	1.6	2.0	2.1
Hair/balding pattern: Pattern 2	1.0	1.2	3.2	-0.5	0.5	1.3	1.1	0.8	1.8	1.5	0.3	1.6	1.3	0.2
Had menopause	0.2	0.2	0.7	-0.1	-0.2	-0.5	-0.6	0.0	-0.6	-0.1	-0.3	-0.3	-0.6	-0.8
Had other major operations	0.2	0.2	2.0	-1.4	0.2	-0.3	-0.3	0.3	-0.2	0.3	-0.1	-0.1	-0.1	0.0
Forced vital capacity (FVC)	0.2	0.6	2.2	-1.5	0.7	0.1	0.5	0.7	-0.2	0.1	1.4	0.9	0.2	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.1	1.5	1.2	0.7	0.9	-0.4	1.1	1.2	0.8	1.0	1.1	0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.1	-0.8	0.9	-0.3	0.1	1.2	0.0	0.1	1.5	0.3	0.0	-0.1
Qualifications: None of the above	0.3	0.6	2.0	0.0	-0.5	0.9	0.8	-0.7	0.2	-0.8	-1.2	0.5	-0.2	-1.4
Financial difficulties in last 2 years	0.3	0.4	1.5	-1.0	0.1	-0.4	-0.2	1.2	0.1	0.5	0.6	-0.1	0.2	0.7
Mouth/teeth dental problems	0.4	0.6	3.4	0.0	-0.5	-0.0	-0.2	-1.0	0.0	1.2	0.2	0.1	0.2	1.8
Heart attack	0.3	0.4	1.3	0.7	-0.5	-0.0	-0.3	-0.8	-0.3	-0.0	-1.1	-0.3	-0.5	-1.0
Allergy	0.9	2.0	8.9	3.0	-1.0	0.4	0.0	-1.6	-0.7	-1.1	-2.5	-0.4	-0.7	-0.8
Pain all over the body in last month	2.2	2.4	5.6	0.2	2.4	2.0	1.9	-0.3	2.1	0.5	1.0	1.9	1.7	0.7
Diabetes (self-reported)	1.3	2.0	4.6	1.9	1.8	2.1	2.1	-1.3	0.6	-0.3	-0.6	1.4	1.4	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.4	0.7	0.7	0.9	0.7	1.3	0.2	1.2	1.1	0.9	0.6
Medication: Ramipril	1.1	1.4	7.1	2.3	0.4	0.5	0.1	-2.7	-0.4	-0.5	-1.2	0.2	-0.6	-0.6
Medication: Simvastatin	0.0	0.1	0.2	0.1	-0.5	-0.2	-0.3	-0.0	-0.3	-0.2	0.1	-0.5	-0.2	-0.1
Fluid intelligence score	0.4	0.8	2.3	-0.1	-0.2	-1.3	-1.3	0.4	-1.5	-0.0	0.4	-1.0	-1.1	-0.4
Illnesses of siblings	0.3	0.4	1.4	-0.2	-0.4	-0.6	-0.5	0.4	-1.0	-0.6	-0.5	-0.7	-0.5	-1.2
Neuroticism score	1.5	3.2	7.7	1.6	2.8	2.4	2.2	-1.5	2.1	-0.0	-0.7	2.1	1.5	0.7
Weight	0.3	1.5	3.7	-0.7	-0.7	-1.9	-1.8	0.4	-1.4	-0.8	0.4	-1.9	-1.4	-0.5
Impedance of arm (right)	0.5	2.5	5.4	1.0	0.2	2.3	2.1	-1.9	1.8	0.6	-1.0	1.8	1.6	1.4
Arm fat percentage (right)	0.1	0.3	0.8	0.5	-0.3	-0.2	-0.4	-0.8	0.5	-0.1	-0.5	-0.9	-0.1	0.7
Trunk fat-free mass	0.7	3.8	7.7	-1.7	-1.1	-2.8	-2.6	0.8	-2.6	-1.2	0.7	-2.5	-2.3	-1.7
Hip circumference	0.2	1.0	1.9	1.3	-0.5	-1.4	-1.4	-0.0	-0.8	-0.9	0.0	-1.4	-1.2	-0.6
Time employed in main current job	1.1	1.3	3.2	-0.6	0.8	0.6	0.6	0.4	1.7	1.8	1.1	1.2	1.1	1.3
Alcohol intake versus 10 years previously	2.0	3.0	9.7	-3.1	1.8	-0.2	0.2	2.7	1.2	1.1	2.9	0.5	1.2	-0.1
Father’s age at death	1.0	1.4	3.0	0.4	-1.6	-1.6	-1.7	-1.2	-1.0	-0.1	-0.4	-1.4	-1.4	0.7
Worrier / anxious feelings	2.3	4.3	9.2	1.5	2.0	3.0	2.9	-1.6	2.9	0.7	-0.4	2.7	2.1	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.5	0.6	1.9	1.7	1.8	-0.4	1.5	-0.2	0.0	1.5	1.4	0.9
Falls in the last year	1.7	2.3	5.8	2.4	-0.9	0.7	0.2	-1.9	-1.0	-1.9	-2.3	-0.2	-0.9	-1.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	0.5	0.2	-0.0	-0.1	-0.6	-0.3	0.0	-0.1	-0.5	0.1	0.3
Number of live births	0.7	1.0	2.3	0.5	0.8	1.1	1.2	0.5	1.5	0.9	0.2	1.0	1.4	1.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	-0.8	0.8	0.4	0.6	0.5	-0.0	0.3	1.1	1.0	0.5	0.5
Pulse rate	0.4	0.7	1.1	-0.7	-0.8	-0.9	-0.7	1.0	-0.7	-1.0	0.7	-0.7	-0.8	-0.8
Happiness	0.1	0.2	0.5	-0.2	0.2	0.5	0.4	-0.6	0.5	0.2	0.3	0.7	0.1	0.1
Noisy workplace	0.2	0.3	0.8	0.0	0.1	0.9	0.8	-0.2	0.5	0.1	-0.5	0.8	0.5	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.1	0.2	-0.5	-0.7	-0.8	-0.8	-0.5	1.5	0.0	0.0	-0.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	5.7	-0.8	-2.2	-2.3	-2.4	-0.2	-2.0	-0.7	-0.4	-2.2	-2.1	-1.1
Mouth/teeth dental problems: Dentures	0.5	0.8	2.9	-0.5	0.1	-0.9	-0.9	0.9	-0.9	-1.0	0.0	-1.1	-0.7	-1.7
Asthma	0.2	0.4	1.5	-0.2	1.2	0.3	0.5	0.1	0.2	-0.6	0.9	0.5	0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	5.8	1.1	-1.2	-0.5	-0.8	-1.9	-1.3	-2.0	-2.4	-0.9	-1.7	-1.5
Medication: Cholesterol lowering	0.2	0.3	0.9	0.7	0.1	0.7	0.6	-0.9	0.3	-0.1	-0.6	0.3	0.4	0.9
Depression (self-reported)	0.7	0.8	2.9	-0.5	1.7	1.1	1.0	0.0	0.9	-0.3	0.2	1.4	0.6	-0.6
Medication: Lansoprazole	1.5	1.7	3.4	0.5	-1.1	-1.9	-1.8	0.1	-1.7	-1.0	0.1	-1.7	-1.7	-0.7
Prospective memory result	1.0	1.3	3.3	0.9	-0.7	-1.1	-1.0	0.7	-1.2	-1.4	-0.6	-1.5	-1.1	-1.8
Lung cancer (father)	1.2	1.4	3.9	-1.2	0.7	0.5	0.7	2.0	0.4	1.6	1.5	0.9	1.3	0.8
Illnesses of mother	0.6	0.8	1.9	0.2	0.2	1.4	1.3	-1.1	0.8	-0.5	-1.1	0.9	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.2	-0.1	0.8	0.8	1.0	0.2	0.2	-0.1	0.4	1.1	0.5	0.2
Pulse wave Arterial Stiffness index	1.6	1.9	4.2	0.7	1.1	1.8	1.6	-1.4	1.5	0.6	-0.4	1.6	1.2	2.1
Impedance of arm (left)	0.7	3.2	7.2	1.3	0.2	2.7	2.5	-1.9	1.9	0.7	-1.2	2.0	1.9	1.7
Arm fat mass (right)	0.2	0.7	2.4	-0.5	-0.5	-1.3	-1.4	0.1	-0.4	-0.2	0.3	-1.6	-0.7	0.1
Trunk predicted mass	0.6	3.6	7.3	-1.8	-1.1	-2.7	-2.6	0.8	-2.5	-1.1	0.8	-2.4	-2.2	-1.5
Standing height	0.2	1.7	4.5	-1.8	-0.7	-1.5	-1.4	0.0	-2.1	-1.1	0.5	-1.3	-1.5	-0.9
Length of working week for main job	0.9	1.0	2.3	0.9	-1.0	-1.2	-1.3	-0.9	-0.4	0.6	-0.6	-1.1	-0.8	1.5
Exposure to tobacco smoke at home	0.3	0.3	1.3	0.5	0.5	-0.3	-0.4	-0.8	0.1	0.6	-0.2	-0.2	-0.1	1.1
Breastfed as a baby	1.8	2.2	4.9	-0.8	-1.9	-2.0	-2.1	0.1	-1.9	-0.6	0.2	-2.2	-1.5	-0.1
Tense / ‘highly strung’	0.3	0.4	1.0	1.0	-0.6	-0.8	-1.0	-0.1	-0.6	0.1	-0.5	-0.6	-0.8	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.9	0.2	1.4	0.2	0.4	0.3	0.6	-0.4	0.6	0.8	-0.0	-0.8
Hair/balding pattern: Pattern 4	0.4	1.1	4.3	-2.1	0.0	-0.8	-0.8	0.4	0.0	1.6	1.1	-0.4	0.2	1.6
Birth weight of first child	0.1	0.3	0.8	0.5	-0.5	0.5	0.4	-0.7	0.4	-0.0	-0.9	0.6	0.1	-0.1
Peak expiratory flow (PEF)	0.1	0.2	1.0	0.7	0.3	-0.2	-0.0	0.3	-1.0	-0.6	0.4	0.2	-0.4	0.0
Pulse wave reflection index	1.8	2.2	6.9	0.7	1.0	1.6	1.4	-1.3	1.7	1.5	-0.6	1.4	1.5	2.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.2	-2.1	0.7	0.1	0.4	2.0	0.7	0.3	1.9	0.9	0.4	-0.3
Loud music exposure frequency	0.7	0.8	3.8	-0.7	0.4	-0.6	-0.3	2.0	-0.4	-0.6	1.3	-0.4	0.0	-1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.2	-0.2	0.3	0.3	0.3	0.0	1.3	1.5	0.4	0.7	0.8	1.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.1	-0.0	0.3	0.6	0.8	-0.0	-0.7	0.2	0.4	0.2	-0.6
Blood clot in the leg (DVT)	0.5	0.6	1.2	-0.8	0.6	1.0	1.1	0.7	1.1	-0.8	0.2	0.8	0.7	-0.4
Medication: Paracetamol	0.1	0.1	0.4	0.4	-0.6	-0.0	-0.1	-0.0	0.3	0.1	-0.6	-0.0	-0.1	-0.4
Headache pain in last month	0.2	0.4	1.6	-0.4	0.6	0.4	0.7	1.3	-0.1	-0.4	0.5	0.5	0.6	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.8	0.2	0.2	0.3	0.4	0.5	0.1	0.2	0.4	0.2	-0.4
Glaucoma (self-reported)	2.5	2.9	12.2	-0.1	-3.5	-1.7	-2.0	-0.7	-1.4	-0.4	-1.3	-2.1	-1.8	-0.9
Gout (self-reported)	0.3	0.5	2.4	0.7	-0.3	0.7	0.6	-1.6	0.6	0.3	-0.2	0.7	-0.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.7	-1.8	0.8	-0.0	0.2	1.9	0.5	1.7	1.9	0.8	0.8	1.4
Medication: Amlodipine	0.2	0.3	1.2	1.1	-0.2	-0.5	-0.6	-0.8	-0.1	0.4	-0.1	-0.2	-0.4	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.2	0.2	0.5	0.6	-0.7	0.3	-0.7	-0.6	0.6	-0.0	-0.0
Birth weight	0.1	0.3	1.2	-0.2	-0.4	-0.2	-0.1	1.1	-0.7	-0.3	-0.7	-0.2	-0.2	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.3	-0.3	0.7	-0.3	-0.2	0.6	-0.0	0.3	1.1	-0.0	0.1	0.3
High blood pressure (siblings)	1.3	1.9	4.0	1.1	1.5	1.4	1.3	-0.9	2.0	1.1	0.3	1.5	1.3	1.9
Forced vital capacity (FVC), Best measure	0.1	0.4	1.2	-0.6	0.7	0.6	0.8	0.4	-0.1	-0.1	0.6	1.1	0.3	-0.4
Body fat percentage	0.1	0.2	0.8	0.5	-0.3	-0.5	-0.7	-0.4	0.2	0.0	-0.2	-0.9	-0.3	0.7
Leg fat percentage (right)	0.1	0.4	0.8	-0.1	0.4	-0.9	-0.9	0.6	0.1	0.5	0.8	-0.8	-0.1	0.8
Arm fat-free mass (right)	0.7	3.5	7.5	-1.4	-1.0	-2.7	-2.6	0.9	-2.4	-0.9	0.7	-2.4	-2.2	-1.6
Exposure to tobacco smoke outside home	2.2	2.9	6.9	2.2	2.6	2.2	2.2	-1.2	1.5	-0.5	-1.7	1.4	1.5	0.4
Comparative body size at age 10	0.5	1.5	4.0	1.5	1.4	1.6	1.3	-2.0	1.0	0.1	-1.0	0.9	0.9	0.3
Number of full brothers	1.2	1.5	2.7	-0.3	1.2	1.2	1.2	0.3	1.5	1.4	1.6	1.6	1.4	1.0
Worry too long after embarrassment	0.5	0.9	2.0	0.1	1.3	1.3	1.3	0.1	1.4	-0.4	0.1	1.1	0.9	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.9	0.0	1.4	0.3	0.5	1.1	0.6	0.5	0.8	0.8	0.6	-0.8
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	0.4	0.8	0.1	0.2	0.5	0.2	0.1	0.8	0.3	0.3	-0.5
Number of children fathered	1.0	1.1	2.1	1.4	1.4	1.2	1.1	-0.1	1.5	0.7	0.3	1.1	1.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.5	2.1	-0.3	0.6	0.5	-1.1	-0.5	-1.3	-1.3	0.1	-0.6	-0.8
Age at first live birth	0.5	1.0	2.3	0.2	-1.0	-1.3	-1.5	-1.2	-0.7	0.1	-0.6	-1.2	-1.3	0.3
Pulse wave peak to peak time	1.6	1.9	4.8	-0.6	-1.1	-1.7	-1.6	1.2	-1.6	-0.7	0.3	-1.6	-1.3	-2.2
Health satisfaction	0.6	0.8	2.4	-1.3	0.2	-0.7	-0.5	1.4	0.9	0.9	1.6	0.3	-0.0	-0.3
Shortness of breath walking on level ground	0.4	0.5	2.4	-1.6	1.3	0.1	0.2	0.5	0.8	-0.4	0.5	0.5	0.1	-0.6
Qualifications: College or University degree	0.4	1.1	2.7	-0.6	-1.5	-0.7	-1.0	-1.4	-0.7	1.6	-0.5	-0.5	-0.4	1.6
Eye problems/disorders: None of the above	0.6	0.7	3.0	1.7	-0.4	-0.0	-0.2	-0.9	-1.5	-0.5	-0.8	-0.1	-0.8	-0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.2	1.5	0.5	0.1	0.2	0.0	-0.4	-1.5	-0.8	0.1	-0.5	-1.1
Emphysema/chronic bronchitis	2.2	2.5	5.0	0.1	2.1	1.6	1.5	-0.4	2.2	2.2	-0.2	2.1	1.6	1.3
Medication for pain relief, constipation, heartburn	0.2	0.3	1.2	-0.9	0.0	-0.5	-0.2	0.8	0.0	0.4	1.1	-0.1	0.1	0.6
Neck or shoulder pain in last month	0.4	0.6	2.5	-1.6	1.0	0.6	0.9	0.7	0.1	-0.8	0.1	0.7	0.5	-0.5
Medication: Blood pressure	0.2	0.4	1.1	0.9	-0.1	-0.8	-0.9	-0.3	-1.1	0.1	-0.1	-0.6	-0.7	0.1
Angina (self-reported)	0.3	0.4	1.8	-0.1	0.7	-0.4	-0.3	1.4	-0.6	-0.1	0.8	-0.2	-0.1	-0.9
Migraine (self-reported)	0.6	0.8	1.9	-0.8	1.4	0.7	0.9	0.9	0.6	0.5	0.8	1.0	0.9	0.8
Medication: Ibuprofen	1.7	2.0	3.4	0.2	-1.5	-1.1	-1.3	-1.3	-1.6	-1.7	-1.8	-1.4	-1.8	-1.3
Medication: Allopurinol	0.7	1.0	3.1	1.8	-0.7	0.7	0.6	-1.7	0.7	-0.4	-1.4	0.5	-0.5	-0.5
Medication: Omeprazole	2.2	2.6	5.6	-1.3	1.7	0.8	1.1	2.3	1.7	1.5	2.4	1.4	1.9	1.1
Medication: Seretide 50 evohaler	0.4	0.4	1.0	1.0	0.8	0.7	0.8	-0.7	0.4	-0.3	-0.6	0.8	0.1	-0.1
Mean time to correctly identify matches	0.2	0.4	1.6	-1.0	0.4	-0.3	-0.1	1.2	0.3	0.2	1.3	0.0	0.2	-0.1
Heart disease (mother)	1.4	1.8	3.9	-1.4	1.1	0.6	0.7	1.3	1.1	1.5	1.8	0.9	1.5	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	4.3	-0.5	0.7	0.2	0.3	0.0	0.4	0.9	0.7	0.1	0.8	2.1
Whole body fat mass	0.2	0.9	3.1	-0.1	-0.6	-1.6	-1.6	-0.1	-0.8	-0.4	0.1	-1.7	-1.1	0.1
Leg fat mass (right)	0.3	1.2	3.3	-0.5	-0.2	-1.8	-1.7	0.9	-0.9	-0.2	0.9	-1.7	-0.9	0.0
Arm predicted mass (right)	0.9	4.5	9.8	-1.6	-1.2	-3.1	-3.0	1.1	-2.7	-1.0	0.8	-2.8	-2.5	-1.9
Pulse rate, automated reading	0.7	2.2	4.8	-1.1	-1.8	-2.2	-2.0	1.3	-1.1	-0.7	0.6	-1.9	-1.5	-1.1
Alcohol intake frequency.	0.5	1.2	6.9	-2.6	0.4	-0.7	-0.4	1.4	-0.5	-0.5	1.5	-0.6	-0.1	-0.7
Comparative height size at age 10	0.6	3.1	6.6	-1.7	-1.3	-2.0	-1.8	0.5	-2.6	-1.8	0.1	-1.8	-2.0	-2.1
Number of full sisters	0.1	0.2	0.7	-0.2	0.2	-0.2	-0.1	0.1	-0.7	-0.4	0.2	-0.4	-0.1	0.8
Suffer from ‘nerves’	0.2	0.3	1.0	0.4	0.7	0.8	0.7	-0.7	0.7	-0.2	-0.2	1.0	0.2	-0.2
Overall health rating	0.2	0.3	0.9	-0.6	-0.4	-0.3	-0.4	0.3	-0.8	-0.8	0.4	-0.5	-0.5	-1.0
Chest pain or discomfort	2.1	3.0	6.4	0.8	2.2	2.5	2.5	0.5	1.9	0.2	0.7	2.2	2.3	0.8
Had major operations	1.0	1.2	3.4	0.6	-1.6	-1.8	-1.8	0.3	-0.1	0.4	-0.0	-1.1	-1.4	0.0
Age at last live birth	0.3	0.4	0.8	0.1	-0.7	-0.8	-0.8	-0.8	-0.3	-0.2	-0.8	-0.9	-0.9	0.3
Family relationship satisfaction	0.2	0.3	0.7	0.9	0.6	0.6	0.6	-0.4	0.2	-0.3	0.4	0.7	0.0	-0.8
Leg pain on walking	1.2	1.5	5.3	-1.3	-0.6	-1.6	-1.3	2.3	-0.2	-0.3	1.8	-0.9	-0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	0.7	0.9	0.7	0.9	0.4	0.2	0.2	0.2	0.8	0.9	0.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.9	0.1	0.6	0.4	0.5	0.7	1.3	2.2	1.5	1.3	1.0	2.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	1.4	-1.4	0.3	0.0	-1.6	-1.2	-0.6	-1.3	-0.3	-0.6	-0.7
Medication: Aspirin	1.5	2.0	4.2	0.8	2.0	2.0	2.0	-0.6	1.4	0.6	-0.2	1.7	1.7	1.0
Supplements: Vitamin C	0.7	0.8	4.4	-2.1	0.1	-0.4	-0.0	1.8	-0.3	-0.6	0.5	-0.3	0.1	0.5
Knee pain experienced in last month	0.1	0.1	0.5	0.4	-0.2	0.1	-0.1	0.5	0.4	0.2	0.4	-0.4	0.7	0.4
Hypertension (Self-reported)	0.2	0.5	2.8	0.4	0.5	-0.0	-0.1	-0.3	-0.1	1.0	0.8	0.3	0.2	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	5.4	-1.3	1.4	-0.5	-0.2	2.3	-0.3	0.3	2.1	0.3	0.3	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.7	0.1	-0.6	-0.1	-0.2	0.1	-0.7	-0.4	-0.8	-0.5	-0.3	-0.2
Illnesses of siblings: Diabetes	0.1	0.2	1.0	0.5	-0.3	0.2	-0.0	-1.0	-0.4	0.2	-0.3	0.1	-0.3	0.2
Smoking status: Previous	0.1	0.2	0.9	-0.2	0.4	0.1	0.1	-0.1	-0.4	-1.0	-0.2	0.1	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	0.0	-0.1	1.1	0.8	-0.6	0.2	1.0	-0.1	0.9	0.8	0.6
Whole body fat-free mass	0.7	3.9	7.4	-1.2	-1.3	-2.7	-2.6	0.4	-2.7	-1.5	0.3	-2.7	-2.4	-1.8
Leg fat-free mass (right)	0.6	3.2	6.9	-0.4	-1.6	-2.1	-2.2	-0.4	-2.4	-1.7	-0.6	-2.6	-2.2	-1.6
Arm fat percentage (left)	0.1	0.3	0.7	0.7	-0.3	-0.1	-0.3	-0.8	0.5	0.0	-0.5	-0.7	0.1	0.8
Average weekly red wine intake	0.4	0.6	2.5	1.6	0.0	-0.5	-0.6	-1.0	0.3	1.0	0.0	-0.4	0.0	1.3
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.8	0.9	-0.6	-0.7	-0.8	-1.7	-1.1	-1.9	-1.7	-1.0	-1.6	-1.5
Mood swings	1.8	3.3	7.2	2.6	1.5	2.5	2.2	-2.7	0.9	-1.0	-2.1	1.5	0.9	0.2
Loneliness, isolation	0.6	0.8	3.6	0.5	1.2	0.7	0.9	0.6	-0.2	-1.2	0.4	0.8	0.0	-1.9
Long-standing illness, disability or infirmity	1.1	1.7	4.1	-0.9	-1.1	-1.4	-1.4	0.8	-2.0	-1.5	0.7	-1.6	-1.3	-1.2
Ever had bowel cancer screening	0.4	0.5	1.1	-0.9	0.2	-0.8	-0.7	0.4	-1.0	-0.5	1.1	-0.6	-0.6	-0.4
Diabetes diagnosed by doctor	0.9	1.5	3.6	1.6	1.4	1.9	1.9	-1.3	0.4	-0.5	-0.7	1.1	1.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.7	0.2	-0.4	-1.3	-1.3	-0.3	-0.5	-0.4	-0.1	-1.1	-1.2	-0.4
Friendships satisfaction	0.4	0.5	1.0	-0.6	-0.8	-0.9	-1.0	0.7	-0.4	0.1	0.9	-0.4	-0.7	-0.4
Qualifications: nursing, teaching	0.3	0.5	2.4	0.2	-0.1	-0.6	-0.5	0.9	-0.2	0.8	1.6	-0.5	0.3	1.0
Commuting to job workplace: Walk	2.3	2.5	7.0	1.1	-1.1	-0.5	-0.6	-1.0	-1.9	-2.6	-2.0	-1.3	-1.5	-2.1
Eye problems/disorders: Cataract	0.7	0.8	2.8	-1.0	0.9	1.0	1.1	0.1	1.7	0.4	0.2	0.6	1.2	0.3
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	8.9	-1.2	-0.5	-1.3	-1.0	1.5	-0.9	-2.2	0.4	-1.0	-1.6	-3.0
Medication for cholesterol	0.4	0.6	2.4	0.5	-0.4	-0.3	-0.3	-0.5	-0.2	-1.5	-1.2	-0.8	-0.6	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.0	0.2	-0.8	-1.4	-1.4	0.2	-0.5	-0.6	-0.2	-1.4	-1.2	-0.9
Back pain experienced in last month	0.0	0.1	0.3	0.1	-0.5	-0.1	-0.2	0.4	-0.2	-0.0	-0.1	-0.3	-0.1	0.2
Mineral and other dietary supplements	0.8	1.0	2.7	-0.6	-1.0	-1.6	-1.5	0.9	-0.7	0.1	0.9	-1.4	-0.8	-0.5
Breast cancer (self-reported)	0.8	1.0	2.4	-1.3	-1.2	-1.3	-1.5	0.0	-0.6	0.8	-0.1	-1.2	-0.9	-0.5
Asthma (self-reported)	0.2	0.4	1.5	-0.5	1.2	0.3	0.6	0.4	0.3	-0.4	1.1	0.5	0.4	-0.7
Osteoporosis (self-reported)	0.4	0.5	2.1	-0.1	-0.7	0.2	-0.0	-1.2	-0.5	-0.7	-1.4	-0.1	-0.6	-0.7
Osteoarthritis (self-reported)	0.3	0.4	1.2	0.5	-0.1	0.9	0.4	-1.0	0.2	-0.6	-1.1	0.1	0.2	-0.7
Medication: Aspirin	1.0	1.3	2.7	0.1	1.6	1.3	1.3	0.3	1.3	1.0	0.3	1.1	1.6	1.2
Medication: Gliclazide	2.6	2.9	6.2	2.2	1.4	2.5	2.3	-2.3	1.2	-0.4	-1.3	1.9	1.2	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	2.6	0.4	-1.6	-1.0	-1.0	-0.0	-0.7	-0.8	-0.1	-1.2	-0.9	-0.8
Smoking status: Current	1.3	2.0	7.4	1.2	-0.6	0.1	0.1	-0.5	-1.4	-2.1	-2.1	-0.4	-1.2	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.9	0.5	2.0	1.2	1.5	1.0	1.6	1.2	1.5	1.5	1.6	1.2
Whole body water mass	0.7	3.9	7.4	-1.3	-1.3	-2.7	-2.7	0.5	-2.6	-1.4	0.4	-2.7	-2.4	-1.8
Leg predicted mass (right)	0.6	3.2	6.8	-0.4	-1.5	-2.1	-2.2	-0.4	-2.3	-1.7	-0.6	-2.6	-2.2	-1.6
Arm fat mass (left)	0.1	0.6	2.3	-0.2	-0.4	-1.2	-1.2	0.0	-0.4	-0.5	0.0	-1.5	-0.7	-0.1
Number of self-reported non-cancer illnesses	0.5	0.8	2.4	0.1	0.8	0.7	0.6	0.3	0.6	1.6	1.1	1.0	1.1	1.3
Average weekly champagne plus white wine intake	0.5	0.7	2.5	1.6	-0.7	-0.6	-0.8	-1.0	-0.6	-0.5	-0.8	-0.5	-1.1	-0.2
Miserableness	0.6	1.0	2.1	1.2	0.8	1.4	1.3	-1.1	1.3	0.0	-0.6	1.2	0.8	0.4
Guilty feelings	0.9	1.4	2.6	0.6	1.3	1.6	1.6	0.8	1.5	0.2	0.7	1.4	1.5	0.2
Wears glasses or contact lenses	0.4	0.4	1.6	-0.4	1.0	0.3	0.5	1.3	0.1	0.1	0.9	0.7	0.5	0.2
Ever taken oral contraceptive pill	1.4	1.6	4.9	-1.1	0.8	-0.1	0.3	2.0	0.8	1.6	2.2	0.6	1.1	1.5
Hearing aid user	0.8	0.9	2.0	-1.4	0.6	1.1	1.1	0.2	1.1	0.7	0.0	1.0	1.2	1.1
Mother’s age at death	0.5	0.6	1.3	0.9	-1.1	-0.5	-0.9	-0.9	-0.7	0.4	-0.7	-0.8	-0.7	0.2
Financial situation satisfaction	0.8	1.0	3.3	-1.3	1.8	1.1	1.3	0.1	1.0	-0.2	-0.0	1.2	0.8	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.1	0.7	-0.4	0.2	0.1	-0.7	1.0	0.2	0.2	0.4	0.2	0.7
Commuting to job workplace: Public transport	5.2	6.2	11.1	0.0	-1.9	-2.9	-2.9	-0.9	-3.2	-2.8	-0.8	-3.0	-3.3	-3.0
Eye problems/disorders: Glaucoma	2.8	3.3	11.5	-0.1	-3.4	-2.0	-2.3	-0.7	-1.5	-0.8	-1.0	-2.5	-2.0	-0.7
Medication: Blood pressure	0.3	0.6	2.6	-0.3	0.6	-0.2	-0.2	-0.0	0.3	1.3	1.2	0.3	0.4	1.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.2	-0.6	-0.4	-0.4	0.4	-0.4	0.2	0.4	-0.3	-0.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.2	0.8	0.9	1.5	1.5	-1.0	0.7	-0.9	-1.3	1.1	0.4	-0.5
High cholesterol (Self-reported)	0.2	0.3	1.5	0.4	0.4	0.5	0.3	-1.2	0.2	-0.4	-0.7	-0.0	-0.0	0.4
Medication: Bendroflumethiazide	0.4	0.6	2.1	-0.7	0.6	-0.2	-0.0	1.2	-0.1	0.9	1.2	0.2	0.5	1.4
Medication: Paracetamol	0.1	0.1	0.4	-0.5	-0.3	-0.2	-0.3	0.1	0.6	0.2	-0.1	-0.1	-0.2	-0.3
Medication: Lisinopril	0.4	0.5	2.5	0.3	0.3	-0.3	-0.3	-1.0	-0.4	0.9	-0.5	-0.3	-0.1	1.6
Medication: Atorvastatin	0.6	0.7	1.6	0.6	0.8	1.1	1.1	-0.7	0.6	0.7	-0.1	1.3	0.8	1.0
Illnesses of father: High blood pressure	0.7	0.9	3.1	0.1	1.3	0.6	0.8	0.3	0.5	0.7	0.9	1.0	0.9	1.8
Alcohol drinker status: Never	2.4	2.8	5.2	0.6	-1.8	-1.8	-2.0	-1.2	-1.9	-1.4	-1.1	-2.1	-2.3	-1.7
Ever smoked	1.1	1.9	5.4	-0.1	-0.2	-0.8	-0.6	0.3	-2.3	-2.2	-1.2	-1.0	-1.4	-2.3
Basal metabolic rate	0.6	3.2	6.4	-1.2	-1.1	-2.5	-2.4	0.4	-2.3	-1.3	0.4	-2.5	-2.1	-1.5
Leg fat percentage (left)	0.1	0.4	1.1	-0.1	0.6	-0.7	-0.6	0.6	0.3	0.5	0.8	-0.5	0.1	1.1
Arm fat-free mass (left)	0.8	3.9	8.3	-1.8	-0.8	-2.9	-2.7	1.2	-2.3	-1.0	1.0	-2.6	-2.2	-1.9
Number of operations (self-reported)	2.0	2.9	7.1	-0.4	-2.2	-2.5	-2.7	0.3	-1.6	-0.2	-0.6	-2.1	-2.2	-1.2
Average weekly beer plus cider intake	0.2	0.3	1.4	0.4	0.2	0.2	0.4	0.3	-0.6	-1.2	-0.3	-0.1	-0.1	-1.1
Irritability	0.5	0.9	3.1	1.7	1.8	0.5	0.3	-1.3	0.6	0.4	-0.4	0.7	0.2	0.6
Risk taking	0.5	0.7	2.8	1.4	0.5	0.8	0.7	-0.7	0.0	-1.2	-1.7	0.3	-0.0	-0.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.6	1.0	-1.6	-1.4	-1.6	-0.7	-1.4	0.5	-0.8	-1.2	-1.3	-0.2
Fractured/broken bones in last 5 years	0.7	0.9	4.7	-0.2	0.1	-0.2	-0.2	-0.4	-0.6	-1.5	-1.2	-0.3	-0.9	-2.2
Age started oral contraceptive pill	0.5	0.7	3.4	1.4	-0.5	-0.0	-0.3	-1.8	0.2	-0.7	-0.8	-0.2	-0.6	-0.4
Diastolic blood pressure, automated reading	0.2	0.7	1.4	1.0	-0.9	-0.6	-0.8	-0.9	-0.4	-0.7	-1.2	-1.0	-0.9	0.3
Ever depressed for a whole week	0.8	1.0	4.4	-1.1	0.7	-0.2	0.2	2.0	0.2	0.2	2.1	0.7	0.3	0.6
Unable to work because of sickness or disability	1.5	1.9	4.6	0.6	1.5	1.3	1.7	0.8	1.2	-2.1	0.4	1.5	0.5	-2.1
Commuting to job workplace: Cycle	0.2	0.3	1.2	-0.3	-0.7	0.1	-0.0	-0.3	0.8	1.1	0.0	-0.1	0.3	0.5
Myopia	0.7	1.0	3.0	1.6	-0.6	-0.1	-0.3	-1.1	-0.6	-1.4	-0.7	-0.3	-1.0	-1.7
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.9	-0.3	-0.9	0.1	0.2	-0.0	0.1	-0.8	-0.7	-0.2	-0.1	-0.9
Cholesterol lowering medication	0.2	0.3	2.1	-1.4	0.2	0.1	0.3	0.3	0.3	0.4	0.7	0.2	0.3	0.2
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	5.0	-1.3	1.9	0.7	1.1	2.2	1.3	1.4	2.2	1.4	1.7	1.1
Pain experienced in last month	0.1	0.2	1.0	0.4	0.6	-0.1	0.1	0.1	0.5	-0.7	-0.4	-0.0	-0.3	-1.0
Supplements: Calcium	0.3	0.3	1.4	-0.2	0.3	0.5	0.6	-0.1	-0.3	-1.2	-0.4	0.3	-0.1	-0.7
Basal cell carcinoma (self-reported)	0.4	0.4	1.5	-1.2	0.8	0.1	0.2	-0.0	0.1	0.8	0.5	0.4	0.3	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.4	0.8	-0.6	-0.0	-0.3	-0.8	-0.3	-0.0	-1.2	-0.3	-0.5	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	-1.1	0.4	0.5	0.6	0.8	0.6	-1.1	0.2	0.4	0.3	-0.7
Heart disease (siblings)	0.7	0.8	3.5	1.4	0.3	0.5	0.3	-1.9	0.2	-1.0	-1.3	0.0	-0.4	0.0
Alcohol drinker status: Previous	0.2	0.2	0.8	-0.0	0.1	0.4	0.2	-0.8	0.9	0.0	-0.1	0.3	0.2	0.6
Pack years of smoking	0.4	0.6	2.3	0.9	-0.2	0.2	0.1	-0.4	-0.9	-1.5	-1.2	-0.7	-0.3	-0.9
Impedance of whole body	0.4	2.0	4.5	0.4	0.5	2.1	2.1	-0.8	1.7	0.9	-0.4	2.1	1.7	1.2
Leg fat mass (left)	0.2	0.9	2.6	-0.5	-0.1	-1.6	-1.5	0.8	-0.7	-0.2	0.8	-1.5	-0.8	0.1
Arm predicted mass (left)	0.6	3.3	7.2	-1.6	-0.8	-2.7	-2.6	1.1	-2.1	-0.6	1.1	-2.4	-1.9	-1.5