Hub : Genes

CRELD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.03000	0.0140	1.4e-02	0.009	0.004	0.002	0.005	0.017	2.3e-02	1.0e-01	1.7e-01	8.0e-02	3.0e-03
2	GTEx	Adrenal Gland	0.17790	0.0687	1.9e-03	0.021	NA	0.017	NA	0.023	5.7e-02	NA	7.8e-02	NA	4.8e-02
3	GTEx	Artery Tibial	0.08980	0.0371	1.5e-03	0.090	NA	0.054	NA	0.075	1.5e-07	NA	4.8e-05	NA	1.5e-06
4	GTEx	Breast Mammary Tissue (Male)	0.00501	0.0489	4.7e-01	0.011	NA	-0.013	NA	0.039	1.7e-01	NA	8.6e-01	NA	4.5e-02
5	GTEx	Breast Mammary Tissue (Female)	0.07186	0.0510	8.4e-02	-0.010	NA	-0.009	NA	-0.008	8.5e-01	NA	7.6e-01	NA	6.5e-01
6	GTEx	Colon Sigmoid	0.20400	0.0750	3.1e-03	0.066	NA	0.016	NA	0.039	2.4e-03	NA	8.7e-02	NA	1.7e-02
7	GTEx	Colon Transverse	0.17200	0.0550	1.7e-04	0.110	NA	0.098	NA	0.078	6.6e-06	NA	2.2e-05	NA	1.5e-04
8	GTEx	Heart Atrial Appendage	0.18500	0.0710	2.5e-03	0.036	NA	-0.004	NA	0.015	9.9e-03	NA	5.2e-01	NA	6.7e-02
9	GTEx	Lung	0.10000	0.0398	1.3e-03	0.072	NA	0.058	NA	0.079	3.3e-06	NA	3.0e-05	NA	1.1e-06
10	GTEx	Skin Sun Exposed Lower leg	0.08500	0.0390	5.2e-03	0.034	NA	0.012	NA	0.021	7.3e-04	NA	3.3e-02	NA	6.7e-03
11	GTEx	Testis	0.26200	0.0730	9.6e-06	0.176	NA	0.149	NA	0.168	2.9e-08	NA	3.8e-07	NA	6.7e-08
12	GTEx	Thyroid	0.15500	0.0600	1.7e-03	0.027	NA	0.028	NA	0.009	3.5e-03	NA	2.9e-03	NA	6.1e-02
13	NTR	Blood	0.02200	0.0079	5.5e-05	0.019	0.012	0.010	0.014	0.017	8.6e-07	6.2e-05	2.2e-04	1.3e-05	2.9e-06
14	YFS	Blood	0.11580	0.0193	0.0e+00	0.222	0.211	0.223	0.224	0.228	7.2e-71	4.2e-67	2.5e-71	1.4e-71	3.4e-73
15	TCGA	Kidney Renal Clear Cell Carcinoma	0.03330	0.0204	5.2e-04	0.015	0.018	0.006	NA	0.007	6.9e-03	3.2e-03	5.8e-02	NA	4.8e-02
16	TCGA	Kidney Renal Papillary Cell Carcinoma	0.15100	0.0840	4.8e-05	-0.005	0.035	0.013	NA	0.011	7.9e-01	4.2e-03	5.9e-02	NA	7.5e-02
17	TCGA	Lung Adenocarcinoma	0.04240	0.0274	2.3e-03	0.022	0.012	0.006	NA	0.012	1.1e-03	1.2e-02	5.4e-02	NA	1.4e-02
18	TCGA	Prostate Adenocarcinoma	0.03740	0.0196	1.2e-05	0.060	0.053	0.054	NA	0.056	6.9e-07	2.8e-06	2.4e-06	NA	1.7e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	0.6	0.9	4.9	1.0	2.0	0.6	-0.3	0.7	2.2	0.8	0.3	-0.5	0.1	-0.3	-0.6	1.2	0.8	0.2	1.0	0.1	0.3
Bipolar Disorder or Schizophrenia	4.6	11.1	23.2	4.3	0.3	3.6	-0.4	3.8	4.4	3.4	3.4	2.2	3.0	-3.4	1.8	3.3	4.1	2.9	4.8	3.0	3.8
Depressed Affect (Nagel 2018)	2.5	5.3	10.2	2.6	0.7	2.6	-0.6	2.6	3.0	2.9	2.2	1.3	2.1	-2.3	-0.4	3.1	2.8	1.8	3.2	1.8	2.4
Depression (Nagel 2018)	0.8	1.2	4.0	1.4	1.0	0.8	-0.6	0.9	2.0	1.2	0.5	-0.4	0.3	-0.6	-1.5	1.8	1.2	0.4	1.4	0.2	1.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.2	1.1	0.8	0.4	0.1	0.6	1.5	1.0	0.3	0.1	0.4	-0.2	0.7	1.2	0.7	0.9	-0.3	0.2	0.2
Neuroticism (Nagel 2018)	3.5	8.3	13.8	3.4	1.1	3.3	-0.0	3.3	3.7	3.7	2.9	1.8	2.7	-3.0	-0.6	3.4	3.6	2.6	3.5	2.3	3.3
Schizophrenia (2018)	7.1	14.8	29.1	4.7	-1.2	4.1	-0.2	4.3	3.8	3.8	4.1	3.3	3.8	-4.1	2.8	3.5	4.5	3.5	5.4	3.7	4.7
Schizophrenia vs Biploar Disorder	1.1	1.4	2.2	1.1	-1.2	1.3	0.6	1.2	-0.1	1.1	1.4	1.4	1.4	-1.5	1.1	0.5	1.1	1.2	1.3	1.4	1.5
Worry (Nagel 2018)	3.2	6.7	10.5	2.8	0.8	3.1	0.3	2.9	3.2	3.2	2.8	2.0	2.6	-2.7	-0.3	3.0	3.0	2.3	3.2	1.9	2.9
Alzheimer’s Disease (in mother)	1.7	2.0	5.0	2.2	-0.7	1.3	0.5	1.3	2.2	1.9	1.2	0.7	1.1	-1.1	0.4	1.7	1.6	1.3	1.3	1.0	1.9
Alzheimer’s Disease (in father)	0.3	0.4	1.4	-0.1	-1.2	0.3	-0.3	0.3	-1.2	1.1	0.4	0.7	0.6	-0.5	0.7	0.6	0.1	0.4	-0.3	0.4	0.1
Alzheimer’s Disease (including proxy)	0.8	1.2	4.0	1.8	-0.6	0.9	0.5	0.9	1.5	2.0	0.8	0.4	0.7	-0.7	0.3	1.9	1.1	1.0	0.8	0.7	1.3
Crohns Disease (2017)	4.4	9.7	15.1	3.9	2.4	3.5	-0.5	3.4	3.8	3.3	3.1	2.4	3.2	-3.2	0.7	3.2	3.7	3.1	3.3	3.0	3.6
Irritable Bowel Disease (IBD)	2.9	7.0	14.2	3.5	1.8	2.8	-0.4	2.7	3.0	3.1	2.3	1.9	2.5	-2.3	-0.6	2.8	3.1	2.4	3.8	2.8	3.2
Ulcerative Colitis (UC)	0.4	0.8	4.2	1.2	0.8	0.6	0.3	0.6	0.5	1.3	0.3	0.3	0.5	-0.2	-1.0	0.9	0.8	0.3	2.1	1.0	0.9
Major Depression (MDD)	0.1	0.1	0.9	-0.1	0.7	0.1	-0.5	0.3	0.5	0.0	0.2	-0.1	-0.0	-0.4	-1.0	-0.1	0.4	0.2	0.3	0.2	0.3
Reaction Time	0.7	1.4	3.4	0.4	1.4	1.1	0.4	1.3	-0.9	1.0	1.4	1.8	1.5	-1.3	0.1	0.7	0.9	1.1	1.5	1.5	1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	3.0	0.8	1.5	0.5	0.0	0.5	1.7	1.0	0.5	-0.2	0.2	-0.4	-0.2	1.5	0.5	0.6	0.1	-0.1	0.2
Breast Cancer	0.3	0.8	3.6	0.2	-1.6	0.9	-1.1	0.7	-0.1	0.1	1.1	1.1	1.1	-1.1	1.9	-0.7	0.5	0.6	0.2	0.5	0.2
Ovarian Cancer	1.7	2.3	6.1	-1.2	-1.2	-1.5	2.5	-1.6	-0.5	-1.4	-1.6	-1.7	-1.7	1.7	-1.5	-0.9	-1.5	-1.5	-1.5	-1.4	-1.6
Prostate Cancer	0.2	0.2	1.9	0.5	0.5	-0.1	-1.4	-0.1	0.4	0.6	-0.3	-0.7	-0.3	0.3	-0.6	0.6	0.0	-0.0	-0.3	0.1	-0.0
Age at First Birth	1.9	2.8	5.0	1.6	0.2	2.0	-0.7	1.8	1.5	2.0	1.8	1.5	1.9	-1.9	1.3	2.1	1.7	1.4	2.2	1.3	1.8
Bipolar Disorder (2011)	0.9	0.9	2.1	1.4	-0.3	1.2	1.2	1.3	1.3	0.9	1.3	0.7	0.9	-1.1	0.0	0.9	1.3	0.7	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.9	-1.2	0.2	-0.9	-0.3	-0.8	-1.7	-1.4	-0.7	-0.2	-0.6	0.6	0.1	-1.5	-0.9	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.4	0.4	1.1	0.8	1.0	0.8	0.8	0.8	1.1	0.7	0.7	0.1	0.4	-0.6	-0.3	0.9	0.8	0.0	0.0	0.0	0.0
Crohns Disease (2012)	5.1	8.2	16.7	3.4	2.6	3.0	0.1	2.9	3.9	3.3	2.7	2.4	2.9	-2.8	1.4	2.9	3.2	2.3	4.1	2.3	3.0
Mean Putamen Volume	0.6	0.7	1.9	0.7	0.6	1.1	0.4	0.9	0.3	0.4	0.9	0.8	1.0	-0.8	-1.4	0.7	0.9	0.5	1.2	0.6	0.9
Fasting Glucose	0.4	0.5	1.5	-1.1	-1.2	-0.4	0.2	-0.4	-0.3	-0.6	-0.5	-0.6	-0.6	0.6	-1.0	-0.5	-0.6	-0.4	-0.7	-0.6	-0.9
HbA1C	0.5	0.5	2.1	-0.4	1.0	1.2	1.4	1.0	0.1	0.2	1.0	0.2	0.3	-1.1	-0.4	-0.1	0.6	0.3	0.6	0.3	-0.0
HDL Cholesterol	0.1	0.2	2.2	-0.5	-1.5	-0.2	0.2	-0.3	-0.2	-0.2	-0.2	-0.2	-0.2	0.4	-0.8	0.2	-0.2	0.0	0.0	0.0	0.0
LDL Cholesterol	0.2	0.2	1.7	0.6	-0.9	0.4	-0.0	0.4	-0.5	-0.0	0.4	0.2	0.3	-0.5	1.3	-0.4	0.5	0.0	0.0	0.0	0.0
Lupus	0.3	0.5	2.7	-0.6	0.2	-0.6	0.3	-0.5	-0.5	-1.3	-0.4	-0.1	-0.4	0.6	-1.7	-1.1	-0.6	-0.1	-0.1	0.1	-0.2
Neuroticism (2016)	1.1	1.6	2.6	1.5	0.8	1.1	-1.4	1.4	1.1	1.2	1.1	1.0	1.2	-1.1	-0.8	1.2	1.5	1.4	1.5	1.6	1.3
Primary Biliary Cirrhosis	0.0	0.1	0.3	0.2	-0.0	0.0	-0.5	0.0	0.2	-0.3	-0.2	-0.2	-0.0	-0.0	-0.3	-0.1	0.2	0.3	-0.3	0.1	0.3
Rheumatoid Arthritis	1.6	2.1	3.8	-1.1	0.1	-1.6	-1.1	-1.7	-0.9	-1.1	-1.7	-1.8	-1.8	1.7	-1.9	-1.0	-1.5	-1.4	-1.9	-1.6	-1.3
Schizophrenia (2014)	5.4	12.0	24.4	4.2	-0.6	3.7	-0.4	4.0	3.2	3.3	3.8	3.2	3.7	-3.8	2.2	3.0	4.1	3.2	4.9	3.4	4.3
Triglycerides	0.0	0.1	0.6	0.3	-0.5	-0.0	-0.8	0.1	0.0	0.1	0.0	-0.2	-0.1	-0.2	0.1	-0.2	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.0	-0.8	-1.9	-1.1	1.7	-1.0	-2.0	-1.2	-0.9	-0.4	-0.8	0.9	0.8	-1.2	-1.1	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.0	1.4	3.5	1.9	0.6	1.1	0.3	1.2	1.0	1.2	0.8	0.9	1.2	-0.8	0.1	1.7	1.4	1.3	1.5	1.4	1.4
Blood Eosinophil Count	0.1	0.4	1.8	0.5	-1.3	0.2	-0.7	-0.2	-1.2	0.9	0.1	0.5	0.3	-0.1	1.4	0.0	-0.3	0.1	-0.1	0.3	0.1
Blood Platelet Count	9.8	113.1	166.4	11.2	2.6	12.1	-0.4	12.1	9.6	10.9	12.3	11.6	12.2	-12.3	7.3	8.3	11.7	11.2	12.9	11.2	11.7
Blood Red Count	0.2	2.2	16.6	-1.5	4.1	0.2	-3.5	-0.3	-1.7	-0.5	0.4	1.2	0.8	-0.1	-0.9	-1.0	-0.8	-0.5	0.4	0.1	-0.9
Blood White Count	0.1	1.0	4.1	-0.8	1.5	0.3	-0.7	-0.1	-2.0	-0.2	0.7	1.8	1.1	-0.6	0.9	-1.4	-0.7	0.5	-1.1	0.0	-0.0
Heel T-Score	3.4	27.2	54.0	-7.2	-0.5	-5.6	0.1	-5.8	-7.3	-6.8	-4.9	-2.7	-4.2	5.0	1.1	-7.0	-6.3	-5.6	-4.9	-4.8	-5.5
BMI	0.3	1.6	7.8	-0.0	0.9	1.1	0.5	0.9	1.2	2.3	1.1	1.5	1.3	-1.1	0.5	2.8	0.7	0.8	1.5	0.7	0.8
Height	0.8	15.8	24.5	5.0	0.4	4.4	1.3	4.5	4.1	4.8	4.2	3.0	3.8	-4.3	-0.0	4.4	4.9	3.8	4.6	4.2	4.7
Waist Hip Ratio (WHR)	0.6	2.9	9.4	-1.0	-0.3	-1.4	-0.1	-1.7	-0.1	-2.6	-1.6	-2.3	-1.8	1.8	-3.1	-1.7	-1.5	-2.1	-1.0	-1.8	-1.3
Systolic Blood Pressure	2.7	13.6	23.6	-4.2	-1.6	-3.7	2.2	-4.3	-2.8	-4.9	-3.7	-3.5	-3.7	3.9	-2.0	-4.0	-4.4	-4.7	-3.0	-4.2	-3.8
Smoking Status	0.1	0.2	1.3	0.4	0.1	0.1	-0.4	-0.2	1.1	-0.4	-0.1	-0.7	-0.2	0.1	-0.6	-0.6	0.1	-0.1	0.2	-0.0	0.2
Allergy or Eczema	1.3	3.5	6.7	-2.1	-1.2	-2.0	0.1	-2.0	-2.0	-2.0	-1.9	-1.6	-1.8	1.9	-1.5	-2.6	-1.9	-2.1	-1.7	-1.9	-2.0
Cardiovascular Disease	0.0	0.2	1.4	0.0	-0.3	0.1	0.7	-0.2	0.3	-0.3	-0.2	-0.1	-0.0	0.2	0.4	0.1	-0.2	-0.6	1.2	-0.1	0.1
Hypothyroidism (self reported)	0.2	0.4	2.3	-0.6	-0.9	-0.2	1.1	-0.5	-1.5	-0.6	-0.1	0.1	-0.1	0.1	0.6	-0.4	-0.5	-0.2	-1.1	-0.3	-0.3
Respiratory disease	0.2	0.5	1.2	0.6	0.3	0.6	-0.4	0.6	-0.2	-0.4	0.7	0.9	0.8	-0.8	0.7	-1.0	0.6	0.5	1.1	0.7	0.8
Type 2 Diabetes (T2D) (2018)	0.5	1.0	6.4	-0.8	-2.5	-0.3	-0.4	-0.6	-1.4	-0.6	-0.1	0.1	-0.0	0.3	0.2	-0.3	-0.8	-1.7	1.2	-1.3	-0.4
Lung FEV1/FVC ratio	0.7	3.5	9.8	-1.7	-3.1	-1.7	1.2	-2.1	-1.4	-0.8	-2.0	-1.5	-1.7	2.1	-2.8	-0.5	-2.1	-2.3	-1.1	-1.8	-1.8
Lung FVC	0.1	0.7	2.7	-1.1	0.4	-0.7	0.9	-0.8	-0.3	-0.5	-0.8	-0.6	-0.8	0.9	0.6	-0.6	-0.8	-0.6	-1.7	-1.0	-1.1
Neuroticism	5.9	14.1	20.4	4.0	0.6	4.5	0.5	4.2	3.8	4.2	4.3	3.3	4.0	-4.3	0.7	3.7	4.3	4.0	4.2	4.1	4.4
Chronotype (morning person)	1.2	2.9	8.8	1.4	3.0	1.6	1.4	1.7	1.3	1.5	1.7	1.5	1.6	-1.8	1.1	1.5	1.7	2.0	1.1	1.9	2.0
Hair Pigment	0.2	5.0	7.2	2.2	0.8	2.6	-0.5	2.4	2.3	1.9	2.3	2.0	2.4	-2.3	1.9	1.9	2.7	2.6	2.4	2.7	2.7
Tanning	1.0	12.8	21.6	-4.0	1.0	-3.9	-0.0	-4.0	-2.5	-3.9	-3.8	-3.7	-4.1	3.6	-1.8	-3.7	-4.0	-3.8	-4.7	-4.1	-4.1
Hand grip strength (left)	1.3	3.4	10.2	2.2	-0.3	2.0	-3.2	1.8	1.8	2.0	1.9	1.3	1.7	-1.8	0.6	1.4	2.1	1.9	1.2	1.8	2.2
Number of treatments/medications taken	0.1	0.2	1.4	0.5	0.4	0.4	0.6	0.2	1.2	0.1	0.1	-0.4	0.1	-0.2	-0.6	0.1	0.3	-0.2	0.6	-0.1	0.1
Average weekly spirits intake	1.0	1.2	5.2	1.0	1.4	1.0	0.0	0.8	1.1	1.5	1.0	0.8	1.0	-0.9	-0.2	2.3	0.8	0.9	1.2	0.7	0.9
Sensitivity / hurt feelings	0.7	1.2	4.0	0.4	2.0	1.1	1.5	1.0	1.1	0.9	1.0	0.9	1.0	-1.1	-1.0	0.3	1.0	1.4	0.7	1.3	1.1
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.1	1.8	-0.1	1.1	-0.2	1.4	2.0	1.1	1.0	0.2	0.8	-1.1	-0.7	1.7	1.7	1.5	1.6	1.6	1.5
Hearing difficulty/problems: Yes	3.2	4.8	7.1	2.6	1.7	2.5	-1.5	2.3	2.4	2.2	2.5	2.1	2.4	-2.5	0.8	1.8	2.3	1.9	2.7	1.8	2.6
Relative age of first facial hair	0.4	0.8	3.0	1.2	0.8	1.1	0.1	0.7	1.4	1.6	0.8	0.3	0.7	-0.8	-0.1	1.7	0.7	0.4	1.0	0.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.7	0.7	0.5	-0.1	1.6	-0.0	0.5	0.6	-0.3	-0.3	-0.2	0.3	-1.5	0.8	0.2	-0.1	0.5	0.4	0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.1	1.1	0.6	1.1	0.4	1.0	0.3	0.9	1.1	1.4	1.4	-1.3	1.0	0.5	1.1	1.4	0.8	1.5	1.3
Ever had hysterectomy (womb removed)	0.5	0.5	3.2	-0.6	0.1	0.2	-0.8	0.1	-1.5	0.6	0.4	1.8	1.0	-0.2	0.5	0.2	-0.4	0.4	0.9	0.7	-0.1
Systolic blood pressure, automated reading	1.6	4.5	8.9	-3.0	-0.0	-2.0	1.6	-2.3	-2.3	-2.9	-1.9	-1.7	-1.9	2.1	-0.9	-2.3	-2.4	-2.5	-2.0	-2.4	-2.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	0.8	-0.3	1.2	0.1	1.0	0.2	0.9	1.4	1.4	1.3	-1.3	0.8	1.0	0.8	0.7	1.5	1.0	1.1
Angina	1.3	1.7	4.9	1.5	-0.2	1.4	-1.1	1.3	0.5	2.0	1.3	1.0	1.1	-1.4	2.2	2.0	1.0	0.8	0.9	0.7	0.8
Medication for hormone replacement therapy	0.2	0.2	1.1	0.0	-1.0	-0.3	0.7	-0.3	0.3	-0.2	-0.4	-0.4	-0.3	0.3	0.2	-0.5	-0.2	-0.3	-0.3	-0.5	-0.4
Vitamin and mineral supplements	1.4	1.9	8.0	0.8	2.8	1.3	-0.9	1.4	0.3	0.6	1.3	1.8	1.6	-1.2	0.9	0.4	1.2	1.4	1.5	1.6	1.3
Supplements: Zinc	0.7	0.8	1.9	1.4	-1.3	0.7	-0.7	0.9	0.5	1.3	0.7	-0.2	0.4	-0.7	0.7	1.4	1.0	0.9	-0.0	0.6	0.9
Medication: Co-codamol	2.6	3.1	6.9	-1.6	-0.2	-1.9	-1.6	-2.0	-1.9	-1.6	-2.0	-1.5	-1.8	1.8	-0.6	-1.6	-2.0	-1.6	-2.6	-1.8	-1.8
Medication: Metformin	0.5	0.7	5.4	-0.7	-2.3	-0.0	-0.5	-0.5	-1.3	-1.0	0.2	0.8	0.4	-0.1	0.9	-0.9	-0.6	-0.8	0.6	-0.5	0.2
Diabetes (father)	2.1	2.6	5.8	-1.7	-1.1	-1.8	-1.6	-2.0	-1.3	-1.6	-1.8	-1.3	-1.5	1.7	-1.4	-1.3	-1.9	-2.4	-0.4	-1.9	-1.6
Diabetes (mother)	0.2	0.3	0.8	-0.6	-0.8	-0.5	0.4	-0.9	-0.6	-0.6	-0.6	0.0	-0.4	0.5	-0.2	-0.1	-0.9	-0.6	-0.4	-0.8	-0.2
Severe depression (siblings)	3.1	3.5	6.1	2.3	-1.0	2.2	-0.9	2.2	1.9	2.2	2.0	1.3	1.7	-2.1	0.5	2.5	2.3	2.1	1.5	1.6	2.1
Pack years adult smoking proportion	0.9	1.4	2.3	-1.5	-1.4	-1.3	1.0	-1.2	-0.8	-1.3	-1.3	-0.9	-1.1	1.3	-0.9	-1.0	-1.2	-1.3	-1.0	-1.1	-1.4
Impedance of leg (right)	0.8	3.6	7.9	-0.9	-1.2	-2.1	-1.8	-1.9	-1.4	-2.8	-2.2	-2.3	-2.2	2.3	-1.3	-2.7	-1.7	-1.8	-1.5	-1.1	-1.8
Leg fat-free mass (left)	1.0	5.5	12.2	1.7	0.9	2.6	1.2	2.4	2.2	3.5	2.6	2.5	2.6	-2.7	0.5	3.4	2.4	2.3	2.3	1.9	2.4
Trunk fat percentage	0.1	0.4	3.3	-0.7	0.7	-0.1	-0.3	0.0	0.7	0.9	-0.1	0.4	0.2	0.2	0.1	1.8	-0.2	-0.0	0.7	0.2	-0.3
Hand grip strength (right)	0.6	1.5	6.9	1.4	0.1	1.1	-2.6	1.1	1.7	1.6	1.0	0.4	0.8	-0.9	0.1	1.0	1.4	1.2	0.2	0.9	1.5
Townsend deprivation index at recruitment	2.5	3.5	8.3	2.3	-0.2	1.9	-1.1	2.0	2.2	2.9	1.7	1.2	1.7	-1.7	0.4	2.9	2.1	1.6	2.2	1.6	1.8
Current tobacco smoking	0.4	0.6	3.2	-0.6	0.6	-0.6	0.6	-0.8	-0.2	-0.8	-0.8	-0.7	-0.6	0.9	-1.8	-0.8	-0.7	-0.6	-0.6	-0.6	-0.7
Average weekly fortified wine intake	0.3	0.3	1.1	-0.7	0.3	-0.2	0.9	-0.5	-0.2	-1.1	-0.2	0.4	0.0	0.1	0.8	-1.0	-0.6	-0.3	-0.2	-0.4	-0.2
Maternal smoking around birth	0.8	1.1	2.1	-1.1	-0.7	-1.3	-0.4	-1.2	-0.6	-0.9	-1.2	-0.7	-1.0	1.3	0.8	-0.6	-1.3	-1.5	-0.2	-1.3	-1.4
Fed-up feelings	1.3	2.4	4.9	1.7	0.8	1.7	-0.8	1.6	2.2	1.5	1.3	0.2	1.1	-1.4	-1.7	2.1	1.8	1.2	2.1	1.6	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	5.1	1.3	0.9	0.8	-0.3	0.9	2.0	1.6	0.7	-0.1	0.5	-0.8	-1.5	2.3	1.0	0.5	1.7	0.6	0.8
Relative age voice broke	0.2	0.3	4.5	-0.0	-0.5	0.0	-2.1	-0.2	0.1	-0.5	-0.1	-0.5	-0.3	0.0	-0.0	-0.3	-0.1	-0.6	0.2	-0.5	-0.2
Taking other prescription medications	0.8	1.2	2.2	0.9	1.5	1.3	0.4	1.0	1.2	1.0	1.2	1.3	1.3	-1.2	0.6	0.9	1.0	0.8	1.4	0.7	0.9
Age when periods started (menarche)	0.2	0.4	1.7	0.5	-1.0	-0.3	-0.5	-0.4	0.3	-0.7	-0.6	-1.1	-0.7	0.6	-1.3	-0.2	-0.0	-0.7	-0.5	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.1	0.2	1.7	0.6	1.8	0.8	0.9	0.5	0.6	0.8	0.7	-0.7	-0.3	0.5	0.8	0.7	1.6	1.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	3.7	8.3	14.8	-3.7	-0.7	-3.0	1.1	-3.2	-3.9	-3.3	-2.6	-1.8	-2.5	2.7	-0.9	-3.7	-3.5	-3.6	-2.8	-2.9	-3.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.0	0.0	-0.1	-0.1	-1.4	-0.0	1.3	0.2	0.0	0.2	0.0	-0.1	0.9	0.2	0.1	0.1	0.3	-0.2	0.4
Qualifications: CSEs or equivalent	0.8	1.0	6.1	-1.3	-2.5	-0.6	1.6	-0.7	-0.4	-1.0	-0.6	-0.5	-0.6	0.6	-0.7	-0.8	-1.0	-0.9	-0.5	-0.5	-1.1
Serious illness, injury or assault to yourself	0.4	0.5	2.2	-0.4	1.5	-0.6	1.1	-0.5	-1.3	-0.5	-0.6	-0.4	-0.5	0.4	0.3	-0.5	-0.4	-0.4	-0.4	-0.3	-0.3
High blood pressure	0.1	0.4	2.9	-0.2	0.0	0.4	1.7	0.2	0.6	-0.4	0.3	0.4	0.4	-0.2	1.1	-0.3	0.2	-0.3	1.4	0.2	0.1
Hayfever, allergic rhinitis or eczema	2.1	4.7	6.3	-2.4	-1.6	-2.3	0.1	-2.3	-2.4	-1.9	-2.4	-2.1	-2.2	2.3	-1.9	-2.4	-2.2	-2.5	-2.2	-2.1	-2.4
Multivitamins +/- minerals	0.5	0.6	7.0	0.0	-2.7	0.2	-0.1	0.1	-0.5	0.3	0.5	0.6	0.5	-0.5	1.7	-0.3	-0.1	0.2	-0.2	0.1	0.1
Stomach or abdominal pain in last month	0.8	0.9	2.3	0.9	-0.2	1.2	-1.5	1.0	1.0	0.7	1.1	0.7	0.9	-1.1	-0.7	0.8	1.0	0.9	1.3	0.7	1.0
Supplements: Glucosamine	0.3	0.4	1.9	-0.4	-0.4	-0.7	-1.4	-0.6	-1.1	-0.4	-0.5	0.2	-0.2	0.4	0.6	-0.7	-0.7	0.0	-1.0	-0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.9	0.5	0.4	0.6	-0.2	0.5	1.0	0.4	0.6	0.6	0.5	-0.4	-0.7	0.3	0.5	0.7	-0.0	0.4	0.7
Medication: Atenolol	0.2	0.3	2.7	0.2	0.3	-0.2	-1.6	-0.2	0.5	0.1	-0.4	-0.5	-0.4	0.5	-0.1	0.8	-0.1	-0.5	0.7	-0.1	-0.0
Medication: Levothyroxine sodium	0.2	0.4	1.2	-0.1	0.1	-0.3	1.0	-0.8	-0.7	-0.4	-0.5	-0.6	-0.5	0.5	-0.2	-0.4	-0.6	-1.0	-0.9	-1.1	-0.5
Sitting height	0.5	3.9	13.1	2.2	0.8	2.1	0.1	1.9	2.6	3.1	1.9	1.1	1.6	-1.8	-0.1	3.6	2.1	1.8	1.8	1.4	2.0
Chronic bronchitis/emphysema (father)	0.4	0.4	2.9	-0.3	-0.3	-0.7	0.1	-0.7	-0.0	-0.6	-0.6	-0.5	-0.6	0.6	-1.7	-0.6	-0.6	-0.8	0.1	-0.7	-0.5
High blood pressure (mother)	0.1	0.2	0.8	-0.5	-0.8	-0.3	0.2	-0.4	-0.1	-0.2	-0.2	-0.3	-0.3	0.4	-0.9	-0.4	-0.5	-0.7	0.1	-0.5	-0.4
Body mass index (BMI)	0.1	0.6	4.7	-0.8	0.4	0.4	-0.3	0.2	0.3	1.5	0.4	0.9	0.6	-0.5	0.6	2.2	0.0	0.1	0.7	-0.1	-0.2
Impedance of leg (left)	0.8	3.9	9.5	-1.1	-0.9	-2.2	-1.8	-2.0	-1.1	-3.1	-2.3	-2.4	-2.3	2.4	-1.3	-2.8	-1.8	-1.8	-1.5	-1.3	-1.8
Leg predicted mass (left)	1.0	5.5	12.1	1.7	0.9	2.6	1.1	2.4	2.2	3.5	2.6	2.6	2.6	-2.7	0.5	3.4	2.4	2.3	2.3	1.9	2.4
Trunk fat mass	0.2	0.9	5.5	-0.2	0.7	0.6	-0.1	0.6	1.1	1.6	0.6	1.0	0.8	-0.6	0.3	2.3	0.4	0.5	1.2	0.6	0.3
Waist circumference	0.2	0.6	4.5	-0.3	0.0	0.6	0.3	0.4	0.8	1.6	0.6	0.9	0.7	-0.5	0.0	2.1	0.3	0.2	1.2	0.2	0.2
Number of incorrect matches in round	0.3	0.4	3.2	0.6	0.4	0.6	1.8	0.5	0.6	0.4	0.6	0.2	0.4	-0.4	-0.2	-0.4	0.7	-0.1	0.8	-0.1	0.8
Past tobacco smoking	0.7	1.4	7.5	-1.6	0.8	-1.2	1.0	-1.1	-2.7	-0.8	-0.8	0.4	-0.4	1.0	-0.6	-0.6	-1.6	-1.1	-1.0	-0.9	-1.1
Alcohol usually taken with meals	0.6	1.0	4.6	-1.0	2.1	-1.1	-0.0	-0.9	-1.6	-1.2	-0.7	-0.0	-0.5	0.7	1.0	-1.1	-1.1	-0.8	-0.8	-0.5	-0.9
Nervous feelings	1.2	2.2	4.9	1.5	1.2	1.6	-0.7	1.6	1.4	2.2	1.6	0.9	1.3	-1.5	-0.7	1.9	1.7	1.4	1.6	1.5	1.4
Frequency of tenseness / restlessness in last 2 weeks	3.8	5.9	13.6	2.5	0.3	2.5	0.6	2.7	3.7	2.6	2.4	1.6	2.2	-2.5	-0.9	2.4	3.0	2.6	3.0	2.7	2.6
Hearing difficulty/problems with background noise	2.4	3.9	7.2	2.5	-0.4	2.1	-0.1	2.1	2.7	2.1	2.0	1.6	1.9	-2.1	-0.3	1.9	2.2	1.9	2.6	1.9	2.4
Hair/balding pattern: Pattern 2	0.5	0.6	3.7	1.0	0.1	0.5	-1.9	0.5	0.9	0.8	0.2	0.1	0.3	-0.2	-0.6	1.0	0.7	0.9	0.4	1.1	0.6
Had menopause	0.8	1.1	4.0	0.5	2.0	0.7	0.9	0.8	-0.1	1.2	0.9	1.4	1.2	-0.9	1.9	0.6	0.6	0.8	0.8	0.4	0.6
Had other major operations	0.4	0.5	3.7	0.5	1.8	0.4	-0.2	0.4	1.9	0.5	0.2	0.0	0.2	-0.2	-0.7	0.3	0.6	0.2	0.5	0.2	0.2
Forced vital capacity (FVC)	0.0	0.1	0.5	0.3	-0.7	0.3	-0.6	0.3	-0.1	0.3	0.3	0.0	0.2	-0.3	0.4	0.1	0.5	0.1	-0.2	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (right)	5.5	12.5	25.8	-4.7	-1.8	-3.7	0.4	-4.0	-5.1	-4.2	-3.1	-1.8	-2.8	3.2	0.1	-4.4	-4.4	-4.3	-3.2	-3.6	-3.9
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	4.0	1.9	-0.4	1.7	0.8	1.7	1.4	1.4	1.9	2.0	1.9	-2.0	1.5	1.2	1.6	1.7	2.0	1.7	1.9
Qualifications: None of the above	1.1	2.3	3.6	-1.9	1.0	-1.7	-0.3	-1.6	-0.1	-1.6	-1.8	-1.6	-1.7	1.9	-1.9	-1.8	-1.5	-1.4	-1.1	-1.4	-1.7
Financial difficulties in last 2 years	3.7	4.9	7.1	2.1	0.2	2.5	0.4	2.6	2.0	2.6	2.6	2.5	2.6	-2.7	2.0	1.9	2.4	2.5	2.2	2.1	2.1
Mouth/teeth dental problems	0.1	0.1	0.6	0.0	0.7	0.3	0.6	0.3	-0.2	-0.6	0.4	0.5	0.4	-0.3	-0.4	-0.3	0.2	0.2	0.1	0.5	0.3
Heart attack	0.2	0.3	1.5	0.3	-0.4	0.4	-0.9	0.1	1.2	0.8	-0.0	-0.5	-0.2	-0.2	0.0	0.9	0.2	-0.1	-0.2	-0.6	-0.1
Allergy	0.4	0.9	3.5	0.8	0.1	0.9	0.5	0.9	0.6	0.8	1.0	1.0	0.9	-0.9	1.9	1.4	0.7	1.1	0.8	0.8	0.9
Pain all over the body in last month	1.7	1.8	4.9	1.5	-0.4	1.4	0.0	1.4	0.0	2.0	1.4	1.6	1.6	-1.3	0.2	1.9	1.3	0.8	2.2	1.1	1.2
Diabetes (self-reported)	0.4	0.6	3.3	0.4	-1.8	0.7	1.2	0.3	-0.0	0.5	0.7	0.2	0.5	-0.5	-0.2	0.8	0.4	-0.6	1.6	-0.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	4.3	-0.7	-1.1	-0.5	-0.3	-0.6	-1.4	-0.7	-0.5	-0.5	-0.5	0.5	-2.1	-0.8	-0.6	-0.5	-0.9	-0.6	-0.6
Medication: Ramipril	1.0	1.3	3.5	-1.3	-0.7	-1.1	1.5	-1.3	-1.5	-0.7	-1.0	-0.7	-0.9	1.0	-0.9	-0.5	-1.5	-1.9	0.1	-1.1	-1.2
Medication: Simvastatin	0.2	0.3	1.4	0.0	-0.4	-0.1	0.6	-0.4	0.6	-0.3	-0.5	-1.2	-0.7	0.6	-0.3	-0.1	-0.3	-1.0	0.1	-0.9	-0.5
Fluid intelligence score	0.2	0.4	0.8	-0.2	-0.8	-0.7	-0.5	-0.7	0.5	-0.4	-0.7	-0.9	-0.8	0.7	-0.6	-0.0	-0.7	-0.4	-0.9	-0.8	-0.8
Illnesses of siblings	0.1	0.1	0.5	0.3	-0.2	0.1	-0.4	0.0	-0.2	0.5	0.2	0.4	0.2	-0.2	-0.7	0.5	0.0	0.5	-0.3	0.4	0.3
Neuroticism score	4.4	9.1	13.8	3.3	0.8	3.5	-0.4	3.4	3.7	3.7	3.3	1.9	2.8	-3.3	-0.7	3.4	3.6	3.2	3.3	3.1	3.4
Weight	0.6	3.1	10.4	0.8	0.7	1.8	0.2	1.6	1.7	2.9	1.9	2.0	1.9	-1.9	0.5	3.2	1.5	1.5	1.9	1.3	1.4
Impedance of arm (right)	0.3	1.3	2.8	-0.4	-0.6	-1.4	-0.1	-1.3	-1.1	-1.7	-1.3	-1.2	-1.3	1.4	-1.0	-1.6	-1.2	-1.1	-0.8	-0.2	-0.9
Arm fat percentage (right)	0.1	0.4	2.3	-1.4	0.0	-0.4	-0.3	-0.5	-0.2	0.6	-0.4	0.3	-0.1	0.3	-0.1	1.5	-0.8	-0.6	0.2	-0.5	-0.8
Trunk fat-free mass	0.7	4.1	7.8	1.7	0.5	2.4	1.0	2.1	1.9	2.8	2.4	2.1	2.3	-2.5	0.6	2.4	2.2	1.8	2.2	1.6	2.3
Hip circumference	1.1	4.6	12.6	0.9	0.5	2.0	-0.4	1.9	1.1	3.5	2.1	2.8	2.4	-2.2	2.6	3.4	1.7	1.9	2.3	1.8	1.8
Time employed in main current job	0.2	0.3	2.0	0.0	-1.0	0.1	1.1	-0.1	0.2	-0.1	0.0	-0.2	-0.0	0.0	-1.4	-0.2	-0.1	-0.4	0.2	-0.3	0.1
Alcohol intake versus 10 years previously	3.2	4.8	14.1	-2.5	-3.7	-2.0	-0.2	-2.2	-1.9	-2.4	-2.0	-1.7	-2.0	2.1	-1.9	-1.9	-2.4	-2.7	-1.3	-2.2	-2.6
Father’s age at death	0.2	0.3	3.1	-0.4	0.3	-0.2	0.3	-0.3	-1.8	-0.3	0.1	0.1	-0.0	-0.1	0.2	-0.1	-0.4	-0.1	-1.2	-0.1	-0.3
Worrier / anxious feelings	2.0	3.7	5.9	1.9	0.1	2.2	0.0	2.2	1.4	2.0	2.3	2.0	2.3	-2.2	-0.9	1.4	2.2	2.4	2.1	2.4	2.3
Frequency of tiredness / lethargy in last 2 weeks	4.1	6.7	10.9	2.3	-0.5	3.0	0.7	2.9	2.5	2.8	2.9	2.8	3.0	-3.0	0.4	2.5	2.9	2.7	3.3	2.9	2.9
Falls in the last year	3.3	4.5	6.9	2.6	0.2	2.5	0.3	2.4	1.6	2.6	2.3	1.8	2.2	-2.4	0.2	2.2	2.5	2.4	2.1	2.4	2.4
Hair/balding pattern: Pattern 3	0.8	1.1	1.9	-1.4	-0.1	-1.1	0.5	-1.0	-1.4	-1.2	-0.8	-0.9	-1.1	0.9	-0.9	-1.1	-1.1	-1.2	-1.2	-1.1	-1.2
Number of live births	0.3	0.4	1.9	-0.7	0.1	0.2	0.6	0.1	-1.4	-0.5	0.4	1.0	0.6	-0.3	0.5	-1.2	-0.1	0.3	-0.8	0.2	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	2.2	-0.2	-1.5	-0.2	-0.5	-0.4	-0.5	-0.0	-0.4	-0.4	-0.4	0.4	-0.1	-0.1	-0.2	-0.5	-0.6	-0.3	-0.2
Pulse rate	1.6	2.7	5.0	-1.7	-1.1	-1.7	-0.2	-1.8	-0.7	-1.1	-1.8	-1.6	-1.8	1.9	-2.1	-0.5	-2.0	-1.9	-1.1	-2.1	-2.2
Happiness	0.7	0.8	2.5	0.9	1.1	0.8	0.1	0.8	1.1	1.6	0.8	0.4	0.6	-0.9	-0.1	1.6	0.9	0.6	0.9	0.9	0.9
Noisy workplace	2.8	3.4	4.8	-2.1	-0.6	-1.9	0.0	-2.0	-1.2	-2.0	-2.1	-2.1	-2.1	2.1	-2.1	-1.9	-1.9	-1.7	-2.2	-1.8	-1.9
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.1	-0.0	1.0	0.4	0.1	0.2	-0.3	0.5	0.3	-0.2	0.1	-0.2	-0.9	0.6	0.2	-0.0	-0.0	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	2.3	1.5	0.1	0.4	0.9	0.3	0.9	0.4	0.3	-0.3	0.1	-0.4	0.2	0.3	0.7	0.4	0.1	0.3	1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	2.6	0.4	-0.9	-0.4	-1.6	-0.4	0.6	0.1	-0.7	-1.1	-0.7	0.8	-0.9	0.4	-0.1	-0.6	0.1	-0.3	-0.2
Asthma	0.5	1.0	2.3	0.4	-0.5	0.9	-0.2	0.9	-0.1	-0.3	1.1	1.5	1.3	-1.1	1.4	-1.4	0.9	0.7	1.4	0.9	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.9	-0.9	1.4	-0.4	-0.8	-0.7	-0.7	-0.6	-0.4	-0.6	-0.5	0.3	-0.5	-0.8	-0.7	-0.8	-0.9	-1.0	-0.5
Medication: Cholesterol lowering	0.3	0.5	1.2	1.1	-0.4	0.9	1.1	0.7	1.0	0.6	0.5	-0.1	0.4	-0.5	0.4	0.7	0.9	0.4	0.8	0.6	0.9
Depression (self-reported)	3.4	4.0	8.2	2.1	-0.3	2.4	1.8	2.2	1.3	2.5	2.2	1.5	2.0	-2.3	1.1	2.3	2.3	1.5	2.9	1.8	2.1
Medication: Lansoprazole	0.6	0.7	2.0	0.6	1.2	0.8	-1.4	0.7	-0.5	1.1	0.9	0.9	0.9	-1.0	1.1	0.9	0.4	0.5	0.1	0.5	0.5
Prospective memory result	2.4	2.9	5.0	1.6	0.9	1.9	-0.4	1.8	1.4	2.0	1.9	2.1	2.0	-1.9	1.5	1.1	1.8	2.2	1.2	1.8	2.0
Lung cancer (father)	4.1	4.8	9.2	2.0	2.2	2.2	0.5	2.5	3.0	2.2	2.2	1.7	2.0	-2.2	0.3	2.5	2.6	2.6	2.1	2.4	2.3
Illnesses of mother	0.4	0.4	2.1	0.1	1.3	0.5	-1.5	0.5	-0.3	0.7	0.5	0.7	0.6	-0.7	0.2	0.0	0.5	0.7	0.4	0.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	3.2	0.2	-1.8	-0.2	-0.8	-0.2	0.0	0.4	-0.3	-0.6	-0.4	0.3	-0.1	0.3	0.0	-0.3	-0.6	-0.3	-0.1
Pulse wave Arterial Stiffness index	2.1	2.5	5.2	1.4	2.3	1.7	0.8	1.9	1.7	1.3	1.7	1.1	1.4	-1.7	0.4	1.4	1.9	1.6	1.8	1.6	1.5
Impedance of arm (left)	0.3	1.2	3.3	-0.2	-0.5	-1.4	-0.4	-1.1	-1.1	-1.8	-1.3	-1.2	-1.3	1.4	-1.3	-1.6	-1.0	-0.9	-0.8	-0.1	-0.8
Arm fat mass (right)	0.1	0.6	4.5	-0.6	0.2	0.4	-0.3	0.2	0.5	1.5	0.5	1.0	0.7	-0.5	0.0	2.1	0.0	0.0	0.9	0.0	-0.0
Trunk predicted mass	0.7	4.2	7.8	1.8	0.6	2.5	0.9	2.1	1.9	2.8	2.4	2.0	2.3	-2.5	0.5	2.4	2.3	1.9	2.2	1.6	2.3
Standing height	0.7	7.4	11.6	3.4	0.8	3.0	0.7	2.9	2.8	3.1	3.0	2.2	2.8	-3.0	-0.2	2.6	3.2	2.8	2.9	3.0	3.4
Length of working week for main job	0.2	0.2	2.7	0.0	-1.7	0.1	0.1	0.2	0.7	-0.3	-0.1	-0.3	-0.1	0.2	-0.3	-0.2	0.3	0.2	0.1	0.2	-0.1
Exposure to tobacco smoke at home	0.8	0.8	1.6	1.2	0.5	1.0	1.1	1.1	1.1	1.0	0.8	0.2	0.6	-0.7	-1.0	0.5	1.2	0.8	1.1	1.1	0.9
Breastfed as a baby	0.6	0.7	2.0	-0.9	1.4	-0.7	1.1	-0.7	-1.3	-0.8	-0.5	-0.1	-0.4	0.5	-0.5	-1.1	-0.9	-0.5	-1.1	-0.4	-0.8
Tense / ‘highly strung’	1.7	2.8	5.8	2.1	0.8	2.0	0.5	1.9	2.4	2.0	1.9	0.9	1.5	-2.0	0.2	1.6	2.1	1.8	1.3	1.4	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.1	-0.2	0.6	-1.0	0.5	0.1	0.7	0.5	0.4	0.4	-0.6	0.1	0.0	0.5	0.3	0.4	0.4	0.3
Hair/balding pattern: Pattern 4	1.3	3.2	7.5	-1.5	-1.0	-2.0	0.4	-2.1	-0.6	-1.8	-2.3	-2.4	-2.3	2.1	-0.2	-1.4	-1.8	-2.7	-0.5	-2.2	-2.0
Birth weight of first child	0.7	1.3	3.6	0.9	1.9	1.1	0.5	0.9	0.7	1.4	1.2	1.4	1.3	-1.0	0.3	1.1	0.9	1.6	0.2	1.1	1.2
Peak expiratory flow (PEF)	2.9	6.7	10.5	2.9	-1.2	3.0	0.0	2.8	2.4	3.2	2.8	2.5	2.8	-2.7	1.8	3.2	2.9	2.3	2.8	2.5	2.8
Pulse wave reflection index	3.6	4.5	7.1	1.9	1.9	2.4	1.1	2.7	1.8	1.8	2.4	2.0	2.2	-2.6	1.4	1.6	2.6	2.4	1.9	2.4	2.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.9	0.9	-1.7	0.6	-0.0	0.5	1.4	1.5	0.7	0.3	0.5	-0.8	0.6	1.7	0.5	0.5	0.6	0.3	0.8
Loud music exposure frequency	0.5	0.6	1.4	0.7	-0.8	0.8	0.3	0.6	0.2	1.0	0.9	1.2	1.0	-1.0	0.7	0.5	0.5	0.8	0.5	0.5	0.7
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.5	1.2	-0.5	1.1	-0.2	1.1	0.6	1.4	1.1	0.7	0.9	-1.1	0.2	1.6	1.0	0.9	0.4	0.8	1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	0.2	0.7	0.4	-0.0	0.4	0.3	0.8	0.5	0.6	0.5	-0.6	0.9	0.1	0.2	0.5	0.7	0.3	0.2
Blood clot in the leg (DVT)	1.2	1.6	2.8	-1.0	0.8	-1.4	-0.9	-1.4	-0.3	-1.4	-1.2	-1.6	-1.5	1.1	-1.1	-1.7	-1.2	-1.4	-1.4	-1.3	-1.1
Medication: Paracetamol	0.9	1.5	4.7	-1.2	-0.2	-1.0	-0.0	-1.2	-0.1	-1.0	-1.3	-1.8	-1.5	1.2	-2.2	-0.7	-1.0	-1.0	-1.8	-1.3	-1.2
Headache pain in last month	0.1	0.2	1.6	0.1	-0.9	-0.0	-0.2	-0.2	-0.8	-0.0	-0.2	-0.3	-0.1	0.3	-1.3	-0.0	-0.1	-0.4	0.3	0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	3.1	-0.7	0.1	-0.3	-1.7	0.0	-0.5	-0.2	0.1	0.6	0.2	-0.2	1.0	-0.6	-0.2	0.3	-0.4	-0.1	-0.4
Glaucoma (self-reported)	3.0	3.5	6.6	1.5	2.2	1.9	-0.6	2.0	2.6	2.0	1.9	1.6	1.8	-1.8	0.6	1.9	1.9	2.2	2.0	2.2	1.7
Gout (self-reported)	0.3	0.4	2.8	0.4	-0.4	0.2	0.3	0.2	1.1	0.6	0.1	-0.6	-0.2	-0.2	-1.7	1.1	0.3	-0.3	1.0	-0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.7	-0.5	-0.3	-0.2	1.7	-0.6	-0.9	-0.7	-0.2	-0.1	-0.2	0.3	1.3	-0.6	-0.5	-0.6	-0.9	-0.7	-0.4
Medication: Amlodipine	0.9	1.3	3.2	1.3	0.3	1.3	1.2	1.2	1.8	1.4	1.3	0.6	1.0	-1.1	0.3	1.3	1.2	1.2	1.0	1.2	1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	1.0	-0.5	0.3	-0.2	0.6	-0.0	-0.5	-1.0	-0.2	-0.1	-0.1	0.2	0.3	-0.9	-0.0	-0.1	-0.1	-0.3	-0.3
Birth weight	3.1	6.7	12.3	2.4	3.4	2.8	-0.5	2.6	1.9	3.3	2.8	2.6	2.8	-2.7	2.2	2.8	2.5	3.5	0.6	2.4	2.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.5	1.4	-1.3	0.6	0.2	0.5	1.5	0.9	0.3	-0.4	0.0	-0.5	0.1	1.6	0.7	0.1	0.4	-0.1	0.4
High blood pressure (siblings)	1.0	1.4	4.2	0.7	0.5	1.4	0.4	1.4	0.8	0.7	1.4	1.4	1.4	-1.4	2.0	0.6	1.3	1.0	1.5	1.0	1.1
Forced vital capacity (FVC), Best measure	0.0	0.2	1.4	0.5	-1.2	0.2	-0.4	0.2	0.2	0.5	0.1	-0.2	0.0	-0.1	0.1	0.3	0.5	0.3	-0.4	0.1	0.3
Body fat percentage	0.1	0.4	2.0	-1.4	0.6	-0.4	-0.5	-0.4	-0.0	0.5	-0.4	0.2	-0.1	0.5	0.2	1.4	-0.7	-0.5	0.2	-0.4	-0.9
Leg fat percentage (right)	0.2	0.7	3.2	-1.8	-0.3	-0.6	-1.4	-0.7	-0.8	0.3	-0.5	0.3	-0.2	0.5	0.5	0.9	-1.0	-0.7	-0.2	-0.8	-1.2
Arm fat-free mass (right)	0.9	4.5	8.3	1.5	0.9	2.5	0.5	2.2	2.2	2.9	2.4	2.3	2.4	-2.4	0.8	2.7	2.3	2.1	2.2	1.7	2.2
Exposure to tobacco smoke outside home	0.3	0.4	2.3	0.0	-1.5	0.3	-1.5	0.3	0.6	0.5	0.2	0.0	0.2	-0.2	-1.0	0.5	0.4	-0.2	0.9	0.3	0.2
Comparative body size at age 10	0.5	1.3	4.7	-2.2	-0.8	-1.3	0.7	-1.2	-1.8	-1.4	-0.9	-0.2	-0.7	0.9	0.2	-0.6	-1.4	-1.3	-0.6	-1.0	-0.9
Number of full brothers	0.4	0.5	3.8	0.2	0.7	0.7	-1.9	0.6	-0.2	0.0	0.8	0.7	0.7	-0.9	0.4	-0.4	0.6	0.1	1.0	0.3	0.5
Worry too long after embarrassment	0.1	0.2	1.3	-0.4	-1.1	0.1	0.0	0.1	-0.4	-0.2	0.3	0.0	0.1	-0.2	0.2	-0.9	0.2	0.2	-0.2	0.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.6	0.4	-0.7	1.2	-0.6	1.2	0.9	1.2	1.3	1.0	1.2	-1.2	-0.4	1.0	1.1	1.0	1.0	1.2	0.8
Wheeze or whistling in the chest in last year	1.0	1.8	3.5	1.3	0.2	1.5	-0.2	1.5	1.3	0.7	1.5	1.4	1.5	-1.6	0.6	0.1	1.6	1.8	1.3	1.9	1.6
Number of children fathered	1.5	1.7	4.3	1.3	0.1	1.5	-0.4	1.5	1.4	1.3	1.3	0.8	1.1	-1.3	2.1	1.2	1.6	1.4	1.0	1.0	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.1	1.1	0.5	1.2	2.0	1.1	1.1	1.4	1.2	1.0	1.1	-1.2	0.8	1.5	1.2	1.1	1.1	1.1	1.2
Age at first live birth	0.3	0.5	1.1	0.8	0.6	0.8	-1.0	0.7	0.8	0.8	0.7	0.2	0.6	-0.8	0.8	1.0	0.8	0.5	0.6	0.4	0.7
Pulse wave peak to peak time	1.7	2.1	4.0	-1.3	-2.0	-1.5	-0.7	-1.8	-1.7	-1.2	-1.6	-0.9	-1.3	1.5	-0.3	-1.4	-1.8	-1.4	-1.7	-1.4	-1.3
Health satisfaction	0.6	0.7	2.7	0.7	0.5	0.5	0.7	0.5	1.1	1.4	0.6	0.8	0.7	-0.7	1.2	1.6	0.4	0.5	1.0	0.8	0.4
Shortness of breath walking on level ground	0.4	0.5	2.6	0.5	1.0	0.2	0.9	0.1	1.6	0.4	0.0	-0.6	-0.2	-0.1	-1.2	1.0	0.2	-0.3	0.9	-0.6	-0.1
Qualifications: College or University degree	0.2	0.6	2.8	-0.4	1.5	-0.5	-1.3	-0.6	-1.7	-0.7	-0.4	-0.3	-0.3	0.4	-1.0	-0.5	-0.6	-0.5	-0.7	-0.2	-0.3
Eye problems/disorders: None of the above	1.7	2.0	3.6	-1.4	-1.3	-1.5	0.5	-1.4	-0.7	-1.9	-1.5	-1.4	-1.4	1.6	-0.7	-1.7	-1.4	-1.2	-1.9	-1.5	-1.6
Mouth/teeth dental problems: Loose teeth	0.1	0.2	1.2	-0.9	-0.1	-0.2	-0.5	-0.2	-0.3	0.0	-0.2	-0.2	-0.2	0.1	1.1	0.2	-0.1	-0.2	-0.0	-0.4	-0.6
Emphysema/chronic bronchitis	0.8	0.9	5.4	0.8	2.3	0.7	-0.2	0.8	1.5	0.9	0.5	0.2	0.5	-0.5	-0.5	0.9	0.9	0.8	0.8	0.9	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	3.5	0.9	-0.9	0.6	0.1	0.8	-0.1	0.4	0.8	1.0	0.8	-0.8	1.9	0.1	0.8	0.8	0.6	1.0	0.8
Neck or shoulder pain in last month	0.3	0.4	2.5	0.8	0.2	0.1	0.4	0.3	1.2	-0.2	-0.1	-1.0	-0.4	-0.0	-1.6	-0.2	0.7	-0.4	0.5	-0.4	0.1
Medication: Blood pressure	0.4	0.6	6.4	0.8	0.0	0.4	2.5	0.2	0.7	0.4	-0.0	-0.6	-0.2	0.0	-1.1	0.5	0.5	-0.0	0.6	0.5	0.7
Angina (self-reported)	1.1	1.5	4.7	1.4	-0.4	1.3	-1.2	1.1	0.5	2.0	1.1	0.7	0.9	-1.2	2.2	2.1	0.9	0.6	0.9	0.6	0.7
Migraine (self-reported)	1.1	1.4	2.8	-0.8	-0.4	-1.0	-1.1	-1.3	-0.8	-1.1	-1.2	-1.4	-1.2	1.2	-1.5	-1.0	-1.1	-1.4	-1.4	-1.7	-1.1
Medication: Ibuprofen	0.2	0.3	2.5	-0.5	1.6	-0.2	-0.5	-0.4	-0.5	-0.3	-0.2	-0.2	-0.2	0.1	-0.1	-0.6	-0.4	-0.4	-0.6	-0.6	-0.3
Medication: Allopurinol	0.7	0.9	2.9	-0.9	-0.7	-0.8	0.6	-0.9	-0.3	-0.4	-0.9	-1.4	-1.2	0.9	-1.7	0.5	-0.8	-1.1	-0.9	-1.3	-1.0
Medication: Omeprazole	1.6	2.0	7.0	1.9	-0.4	1.4	0.2	1.4	2.7	1.8	1.1	0.7	1.1	-0.9	-0.2	1.8	1.6	1.2	1.9	0.8	1.5
Medication: Seretide 50 evohaler	0.7	0.8	3.4	0.3	0.7	1.1	-0.5	0.9	0.4	0.1	1.2	1.2	1.1	-1.2	1.9	0.1	1.0	0.8	0.6	0.8	0.9
Mean time to correctly identify matches	1.7	3.3	6.3	1.2	2.0	1.9	1.1	2.1	0.2	1.5	2.1	2.5	2.3	-2.0	0.7	1.2	1.7	2.0	2.2	2.3	1.8
Heart disease (mother)	0.3	0.3	2.4	0.8	0.2	0.1	1.1	0.5	1.5	-0.1	0.2	-0.2	0.0	0.0	0.1	0.4	0.6	0.2	0.9	-0.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	7.5	-2.0	-0.3	-1.7	-0.0	-1.7	-2.0	-2.7	-1.7	-1.2	-1.6	1.6	-0.3	-2.4	-1.7	-1.9	-1.3	-1.5	-1.8
Whole body fat mass	0.2	0.8	5.3	-0.4	0.6	0.7	-0.3	0.6	0.9	1.6	0.7	1.1	0.9	-0.6	0.6	2.3	0.4	0.4	1.1	0.4	0.2
Leg fat mass (right)	0.2	0.8	4.7	-0.6	0.1	0.6	-0.4	0.5	0.4	1.6	0.7	1.3	1.0	-0.8	0.9	2.2	0.2	0.4	0.9	0.2	0.1
Arm predicted mass (right)	1.1	5.4	9.9	1.8	0.9	2.7	0.6	2.5	2.3	3.1	2.7	2.5	2.7	-2.7	0.6	3.0	2.5	2.3	2.5	1.9	2.5
Pulse rate, automated reading	1.6	5.1	10.9	-2.7	0.0	-2.4	0.3	-2.4	-1.5	-1.7	-2.5	-2.4	-2.4	2.7	-2.5	-0.8	-2.6	-2.4	-2.2	-2.7	-3.3
Alcohol intake frequency.	0.4	1.0	5.9	1.4	-2.4	0.3	0.5	0.3	1.2	1.4	0.0	-0.4	-0.1	0.1	-1.2	1.5	0.5	-0.1	1.3	0.3	0.3
Comparative height size at age 10	3.0	16.6	26.8	4.6	0.8	4.3	0.5	4.5	3.6	4.4	4.4	4.1	4.4	-4.4	2.1	3.9	4.5	4.9	4.1	5.2	4.8
Number of full sisters	1.4	1.7	5.1	-1.2	-0.7	-1.3	0.1	-1.4	-0.3	-1.3	-1.4	-1.6	-1.5	1.4	-0.5	-0.9	-1.3	-1.7	-1.2	-2.3	-1.4
Suffer from ‘nerves’	1.9	3.0	4.7	1.3	1.8	2.1	0.7	2.0	1.7	1.7	2.1	1.6	1.8	-2.0	0.7	1.2	2.0	1.7	2.2	2.0	1.7
Overall health rating	1.0	2.0	3.1	1.5	0.4	1.4	0.3	1.5	1.8	1.7	1.4	1.5	1.6	-1.5	-0.4	1.6	1.5	1.5	1.7	1.6	1.5
Chest pain or discomfort	6.6	9.6	14.6	3.6	-0.4	3.6	0.6	3.5	3.6	3.4	3.4	2.8	3.2	-3.4	1.3	3.0	3.5	3.2	3.8	2.9	3.3
Had major operations	0.1	0.2	0.8	0.1	0.6	-0.2	0.5	-0.2	-0.5	-0.2	-0.2	-0.4	-0.2	0.1	0.7	-0.3	-0.0	0.1	-0.9	-0.4	0.2
Age at last live birth	0.4	0.6	1.7	0.8	0.2	1.0	0.6	0.8	1.3	0.8	0.7	0.2	0.6	-0.8	0.0	1.0	1.0	0.7	0.7	0.7	0.9
Family relationship satisfaction	1.9	2.4	4.5	1.8	0.3	1.8	0.3	1.8	1.6	2.1	1.7	1.0	1.5	-1.7	0.9	2.1	1.9	1.3	1.7	1.4	1.5
Leg pain on walking	0.5	0.6	1.1	-0.8	-0.5	-1.1	-0.4	-0.8	-0.8	0.4	-0.9	-0.6	-0.8	1.0	-0.8	0.8	-0.9	-0.8	-0.5	-0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	0.5	-0.7	0.7	-0.2	0.8	0.7	-0.0	0.7	0.5	0.6	-0.7	0.9	0.7	0.7	0.8	0.6	0.9	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.6	-0.0	0.5	0.1	-0.5	0.3	1.2	-0.3	-0.1	-0.4	-0.2	0.1	-0.5	0.4	0.3	-0.1	0.5	-0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	7.2	-0.8	0.5	-0.2	-0.9	-0.3	0.8	-0.3	-0.4	-0.3	-0.3	0.6	-2.7	0.3	-0.4	-0.6	0.4	-0.4	-0.9
Medication: Aspirin	0.3	0.4	1.1	0.3	0.6	0.8	0.4	0.7	0.4	0.8	0.7	0.5	0.6	-0.7	1.1	1.0	0.5	0.2	0.6	0.2	0.3
Supplements: Vitamin C	1.4	1.7	2.8	-1.1	-1.5	-1.5	-0.0	-1.5	-1.0	-0.8	-1.6	-1.4	-1.5	1.5	-1.2	-0.8	-1.4	-1.1	-1.7	-1.2	-1.4
Knee pain experienced in last month	0.3	0.5	2.7	0.7	0.5	0.3	1.2	0.4	-0.4	1.2	0.3	0.1	0.3	-0.3	-0.9	1.6	0.6	0.4	0.6	0.5	0.7
Hypertension (Self-reported)	0.2	0.5	5.3	-0.3	0.0	0.2	2.3	0.0	0.3	-0.5	0.1	0.2	0.2	-0.0	1.1	-0.4	0.0	-0.4	1.2	0.1	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.3	-0.3	-0.9	-0.6	0.2	-0.6	-0.3	-0.1	-0.8	-0.8	-0.8	0.8	0.2	-0.2	-0.5	-0.8	-0.3	-1.1	-0.8
Illnesses of father: Heart disease	2.4	3.4	6.7	2.0	0.8	2.0	0.9	2.0	2.6	2.0	1.8	1.3	1.7	-1.9	2.3	1.8	2.0	2.0	1.7	1.8	1.7
Illnesses of siblings: Diabetes	0.4	0.5	2.0	0.5	-0.2	0.7	-0.6	0.6	1.4	0.8	0.5	-0.1	0.3	-0.6	0.9	1.2	0.8	0.2	1.1	-0.0	0.3
Smoking status: Previous	0.3	0.5	2.9	0.8	-1.2	0.5	-1.1	0.5	1.7	-0.2	0.2	-0.5	0.0	-0.4	0.4	-0.3	0.8	0.5	0.6	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	3.0	0.8	-0.3	0.2	-0.6	0.2	0.2	0.3	0.1	-0.5	-0.1	-0.2	-1.7	-0.1	0.5	0.2	0.1	0.2	0.7
Whole body fat-free mass	0.9	5.1	10.1	1.8	0.8	2.6	1.1	2.3	2.1	3.2	2.6	2.4	2.5	-2.7	0.6	2.9	2.4	2.1	2.3	1.8	2.4
Leg fat-free mass (right)	1.1	5.7	11.9	1.8	1.0	2.7	1.0	2.4	2.4	3.5	2.7	2.5	2.6	-2.8	0.5	3.4	2.5	2.3	2.3	1.9	2.5
Arm fat percentage (left)	0.1	0.4	2.1	-1.3	-0.0	-0.4	-0.3	-0.5	-0.3	0.6	-0.3	0.5	-0.0	0.3	-0.0	1.4	-0.8	-0.5	0.1	-0.4	-0.8
Average weekly red wine intake	1.1	1.6	3.6	1.0	1.9	1.2	-1.0	1.2	0.1	0.7	1.5	1.8	1.5	-1.5	1.6	0.2	1.1	1.4	0.5	1.3	1.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	2.8	0.0	0.1	0.4	-0.5	0.2	0.0	0.2	0.3	0.1	0.3	-0.3	-1.7	0.1	0.1	-0.0	0.3	0.3	-0.2
Mood swings	1.4	2.6	5.0	2.0	0.1	1.8	0.4	1.8	2.2	1.8	1.5	0.6	1.2	-1.6	-0.7	2.0	2.0	1.7	1.7	1.8	1.8
Loneliness, isolation	1.1	1.5	4.2	1.1	-0.9	1.1	-0.2	1.3	1.7	1.7	1.0	0.9	1.1	-1.1	0.8	1.7	1.3	1.0	2.0	1.1	1.0
Long-standing illness, disability or infirmity	0.4	0.7	7.0	0.5	-0.1	0.7	2.6	0.6	0.1	0.7	0.5	0.7	0.7	-0.5	-0.7	0.5	0.5	0.4	0.5	0.6	0.4
Ever had bowel cancer screening	0.2	0.2	0.7	-0.4	-0.6	-0.5	-0.4	-0.3	-0.1	-0.8	-0.4	-0.3	-0.4	0.4	-0.4	-0.7	-0.3	-0.6	0.1	-0.5	-0.5
Diabetes diagnosed by doctor	0.5	0.7	4.0	-0.7	-2.0	-0.4	-0.1	-0.7	-1.3	-0.6	-0.3	-0.3	-0.4	0.5	0.2	-0.3	-0.8	-1.6	0.8	-1.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	4.6	-1.3	-0.2	-1.8	-0.9	-2.1	-1.0	-2.0	-2.0	-2.1	-2.0	1.9	-2.1	-1.6	-1.8	-2.1	-1.5	-1.8	-1.4
Friendships satisfaction	1.5	1.8	2.8	1.4	0.5	1.4	1.3	1.4	0.5	1.5	1.5	1.7	1.6	-1.5	1.1	1.3	1.2	1.5	1.3	1.5	1.3
Qualifications: nursing, teaching	2.0	3.1	9.6	1.5	-1.0	1.8	0.7	1.6	-0.8	1.5	2.2	2.9	2.3	-2.1	3.1	0.7	1.3	1.7	1.2	1.5	1.5
Commuting to job workplace: Walk	0.6	0.7	2.2	0.6	1.1	0.5	0.7	0.7	-0.1	0.4	0.7	0.8	0.7	-0.8	1.5	0.1	0.7	1.3	0.0	1.2	0.9
Eye problems/disorders: Cataract	1.1	1.2	3.6	-1.0	-0.5	-1.4	-0.1	-1.3	-1.9	-1.2	-1.3	-1.1	-1.2	1.1	-0.4	-1.3	-1.2	-1.3	-0.7	-0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	2.4	1.3	-0.4	1.2	-1.4	1.3	0.6	1.6	1.3	1.4	1.3	-1.3	1.5	0.9	1.3	1.4	1.2	1.1	1.3
Medication for cholesterol	0.4	0.5	1.2	1.1	-0.2	0.6	-0.8	0.8	0.4	0.7	0.6	0.2	0.4	-0.6	-1.1	0.4	1.0	1.0	0.2	1.0	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.2	-1.5	-0.4	-1.2	-0.0	-1.1	-1.3	-1.8	-1.2	-0.8	-1.0	1.1	-0.5	-1.1	-1.1	-1.1	-0.8	-1.1	-1.1
Back pain experienced in last month	1.0	1.4	2.7	1.1	0.3	1.6	-0.3	1.3	1.3	1.0	1.6	1.6	1.6	-1.7	0.4	0.3	1.1	1.6	0.6	1.1	1.3
Mineral and other dietary supplements	0.2	0.2	1.8	0.5	0.1	0.1	-0.7	0.3	1.4	-0.0	-0.0	-0.4	-0.2	0.3	-0.1	0.4	0.5	0.2	0.6	0.0	0.4
Breast cancer (self-reported)	0.8	1.0	5.8	0.8	2.4	0.1	1.7	0.3	2.3	0.0	-0.1	-0.7	-0.3	0.1	-0.6	0.6	0.6	0.3	0.4	0.0	0.6
Asthma (self-reported)	0.3	0.6	2.2	0.3	-0.5	0.6	-0.2	0.7	-0.0	-0.5	0.8	1.1	1.0	-0.8	1.1	-1.5	0.7	0.5	1.1	0.7	0.9
Osteoporosis (self-reported)	1.1	1.4	4.6	0.9	1.9	1.0	0.2	1.0	2.1	1.4	0.8	0.7	0.9	-0.9	-1.1	1.4	1.1	1.2	1.1	1.3	1.0
Osteoarthritis (self-reported)	1.4	1.8	5.6	-1.4	0.2	-1.5	1.0	-1.5	-2.4	-1.2	-1.5	-0.8	-1.2	1.4	0.1	-1.5	-1.6	-1.4	-1.5	-1.2	-1.3
Medication: Aspirin	0.3	0.3	1.3	0.2	0.4	0.7	0.7	0.6	0.1	0.9	0.6	0.4	0.5	-0.6	1.0	1.2	0.4	0.3	0.3	0.1	0.1
Medication: Gliclazide	0.2	0.2	1.2	-0.3	-1.1	0.0	-1.0	0.1	-0.5	-0.2	0.3	0.6	0.4	-0.2	0.3	-0.4	0.0	-0.2	0.7	-0.0	0.1
Illnesses of father: None of the above (group 1)	0.0	0.1	0.3	0.2	0.4	-0.2	0.1	-0.2	-0.2	-0.2	-0.2	-0.1	-0.2	0.3	-0.2	-0.1	-0.1	0.2	-0.5	0.1	0.2
Smoking status: Current	0.6	1.0	3.4	-0.8	0.9	-0.9	1.0	-1.0	-0.2	-0.9	-1.0	-1.1	-0.9	1.2	-1.8	-1.0	-0.9	-0.8	-0.9	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	5.3	0.1	-2.3	0.0	-0.9	0.0	-0.0	0.4	-0.1	-0.3	-0.1	0.2	0.4	0.5	0.2	-0.1	-0.6	-0.2	-0.1
Whole body water mass	0.9	5.2	10.4	1.8	0.8	2.6	1.0	2.3	2.2	3.2	2.6	2.4	2.6	-2.7	0.6	3.0	2.4	2.2	2.4	1.8	2.5
Leg predicted mass (right)	1.0	5.5	11.5	1.7	1.0	2.6	1.0	2.4	2.3	3.4	2.7	2.5	2.6	-2.8	0.5	3.3	2.4	2.3	2.3	1.8	2.5
Arm fat mass (left)	0.2	0.8	5.7	-0.3	0.2	0.7	0.0	0.5	0.8	1.7	0.7	1.2	0.9	-0.7	0.2	2.4	0.3	0.3	1.2	0.2	0.3
Number of self-reported non-cancer illnesses	1.5	2.5	5.4	1.3	0.7	1.8	2.1	1.7	1.7	1.4	1.7	1.6	1.8	-1.7	-0.4	1.1	1.6	1.4	2.3	1.7	1.4
Average weekly champagne plus white wine intake	0.3	0.5	3.7	-0.0	1.4	-0.3	-1.9	-0.2	-0.6	-0.1	-0.2	-0.1	-0.1	0.0	1.1	-0.0	-0.2	0.2	-0.8	0.1	0.0
Miserableness	1.3	2.3	6.9	1.8	1.0	1.5	-1.2	1.6	2.6	2.0	1.1	-0.1	0.8	-1.3	-0.8	2.2	1.9	1.4	1.5	1.3	1.3
Guilty feelings	6.1	9.2	14.0	3.3	0.8	3.4	-0.4	3.5	2.7	3.3	3.6	3.0	3.4	-3.5	0.8	2.4	3.6	3.5	3.2	3.3	3.7
Wears glasses or contact lenses	2.6	3.0	4.5	2.0	0.3	2.1	0.6	2.1	1.7	1.8	2.0	1.7	2.0	-2.0	1.3	1.1	2.0	1.7	1.9	1.8	1.6
Ever taken oral contraceptive pill	1.7	1.9	7.3	-1.6	-1.1	-1.3	-1.0	-1.0	-2.1	-2.0	-1.0	-0.6	-0.9	0.8	0.5	-2.7	-1.2	-0.9	-1.6	-1.1	-1.1
Hearing aid user	1.8	2.0	5.3	-0.8	0.0	-1.5	-0.4	-1.6	-0.4	-1.8	-1.5	-1.8	-1.7	1.6	-2.3	-1.2	-1.5	-1.5	-1.2	-1.6	-1.0
Mother’s age at death	0.6	0.7	1.6	-0.8	-1.0	-0.8	-1.0	-0.8	-1.3	-1.1	-0.8	-0.9	-1.0	0.8	-0.0	-0.7	-0.9	-0.9	-0.9	-0.6	-0.9
Financial situation satisfaction	0.2	0.2	1.8	-0.2	0.6	-0.1	1.3	-0.2	0.1	-0.4	-0.3	-0.6	-0.4	0.0	0.3	-0.1	-0.1	-0.6	-0.0	-0.6	-0.3
Tinnitus: Yes, now most or all of the time	5.5	6.4	9.3	2.7	1.0	2.9	-0.7	2.8	1.5	2.6	3.0	2.8	2.9	-3.1	2.0	2.1	2.8	2.7	2.7	2.9	2.9
Commuting to job workplace: Public transport	1.4	1.6	3.9	1.3	0.7	1.4	0.5	1.4	0.9	2.0	1.4	1.3	1.4	-1.3	0.3	1.8	1.3	1.5	0.8	1.2	1.2
Eye problems/disorders: Glaucoma	1.3	1.6	4.0	0.7	2.0	1.1	-1.8	1.2	1.5	1.4	1.0	0.9	1.0	-1.0	0.5	1.4	1.0	1.2	1.5	1.4	0.7
Medication: Blood pressure	0.7	1.3	7.5	-0.0	1.4	0.8	0.9	0.7	0.8	0.5	1.0	1.5	1.2	-0.9	2.7	0.8	0.5	0.3	1.9	0.8	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.1	-0.6	0.2	-0.7	1.0	-0.8	-0.5	-0.9	-0.6	-0.4	-0.6	0.5	-0.1	-0.7	-0.7	-0.7	-1.0	-0.9	-0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.4	-1.2	-0.6	-0.8	1.0	-1.0	-1.5	-0.6	-0.7	-0.2	-0.4	0.6	0.3	-1.1	-1.2	-0.9	-0.9	-0.7	-1.1
High cholesterol (Self-reported)	0.4	0.7	2.2	-0.7	-0.4	-0.7	-0.3	-0.8	-0.1	-1.0	-0.9	-1.2	-1.0	1.0	-1.5	-0.6	-0.7	-1.2	-0.4	-1.1	-0.7
Medication: Bendroflumethiazide	0.3	0.4	3.4	-0.0	0.0	0.0	1.6	0.1	-0.1	-0.4	0.2	0.6	0.4	-0.1	1.8	-0.5	-0.0	0.1	0.5	0.3	0.1
Medication: Paracetamol	0.7	1.2	3.1	-1.0	0.2	-0.8	-0.0	-1.0	-0.5	-0.6	-1.2	-1.7	-1.3	1.1	-1.8	-0.2	-0.9	-1.0	-1.7	-1.2	-1.1
Medication: Lisinopril	0.2	0.2	1.9	-0.5	1.4	0.1	1.0	-0.1	0.5	-0.4	-0.1	0.0	0.0	0.2	-0.4	0.4	-0.1	-0.3	0.4	-0.0	-0.1
Medication: Atorvastatin	0.8	1.0	3.9	1.1	-1.0	0.8	-2.0	0.9	0.9	1.0	0.7	0.2	0.6	-0.7	-0.6	1.4	1.1	0.6	1.3	0.9	0.8
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.2	-0.5	0.5	-0.5	0.2	0.0	-0.0	0.5	0.2	0.4	-0.6	0.3	-0.1	0.2	-0.0	0.2	0.1	0.3
Alcohol drinker status: Never	0.2	0.2	1.5	-0.3	0.7	-0.0	-1.2	-0.3	0.1	0.3	-0.2	-0.0	-0.1	0.3	-0.8	0.3	-0.3	-0.1	-0.0	-0.2	-0.3
Ever smoked	2.1	3.7	9.8	2.3	0.6	2.2	-0.4	2.1	3.1	2.0	1.8	1.0	1.7	-1.9	1.0	1.6	2.5	2.2	1.9	2.1	2.1
Basal metabolic rate	0.8	4.4	9.8	1.5	0.7	2.4	0.8	2.1	2.1	3.1	2.3	2.2	2.3	-2.4	0.4	3.1	2.1	1.9	2.2	1.5	2.1
Leg fat percentage (left)	0.2	0.7	3.7	-1.9	-0.1	-0.6	-1.2	-0.7	-0.6	0.1	-0.5	0.2	-0.2	0.5	0.4	0.8	-1.1	-0.8	-0.3	-0.9	-1.2
Arm fat-free mass (left)	1.1	5.4	10.7	1.7	0.8	2.7	0.5	2.4	2.4	3.3	2.7	2.5	2.6	-2.7	0.5	3.1	2.5	2.2	2.7	1.8	2.4
Number of operations (self-reported)	1.1	1.6	6.4	1.0	2.5	1.2	1.5	1.2	1.6	1.1	1.1	1.1	1.2	-1.0	-1.2	0.2	1.4	1.3	0.9	1.0	1.2
Average weekly beer plus cider intake	0.3	0.5	5.2	-1.2	-0.0	-0.2	2.3	0.0	-0.7	-0.8	-0.1	-0.2	-0.2	0.1	0.1	-0.8	-0.1	-0.1	-0.4	0.1	-0.4
Irritability	3.1	5.3	11.2	3.0	0.6	2.5	0.6	2.3	3.4	3.3	2.1	0.8	1.7	-2.1	-1.2	3.1	2.6	2.3	2.3	2.2	2.4
Risk taking	0.1	0.1	0.4	-0.3	-0.1	-0.1	-0.6	-0.2	-0.5	-0.2	-0.1	-0.2	-0.2	-0.2	0.4	-0.4	-0.3	-0.4	-0.3	-0.6	-0.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	6.2	0.8	2.5	1.0	0.0	0.9	0.9	0.9	0.8	0.8	0.9	-0.9	-0.2	1.1	1.1	1.3	0.2	0.6	1.0
Fractured/broken bones in last 5 years	2.4	3.2	7.9	2.3	0.8	1.6	1.5	1.9	2.8	2.2	1.3	0.6	1.2	-1.3	-0.7	2.2	2.1	2.0	1.9	2.0	1.7
Age started oral contraceptive pill	2.1	2.6	7.1	0.9	1.5	1.7	-0.7	1.7	0.8	1.6	2.1	2.1	2.0	-2.0	1.1	1.6	1.3	1.1	2.7	1.5	1.4
Diastolic blood pressure, automated reading	0.9	2.9	7.5	-2.7	0.0	-1.7	1.4	-1.8	-1.8	-1.9	-1.5	-1.2	-1.5	1.6	-1.3	-1.7	-2.0	-1.8	-1.9	-1.8	-1.9
Ever depressed for a whole week	1.7	2.0	3.7	1.5	-0.7	1.4	0.0	1.4	0.6	1.1	1.6	1.8	1.7	-1.7	1.9	0.8	1.3	1.6	1.5	1.6	1.8
Unable to work because of sickness or disability	1.0	1.3	7.5	1.5	-0.7	0.9	0.2	0.9	1.5	0.9	0.6	0.1	0.5	-0.6	-2.7	1.1	1.1	0.6	1.5	1.1	0.9
Commuting to job workplace: Cycle	0.4	0.5	2.9	-0.2	1.2	-0.1	-1.7	-0.2	-1.4	0.0	0.1	0.0	0.0	-0.2	-1.3	-0.2	-0.2	-0.1	-0.6	-0.3	0.0
Myopia	0.9	1.3	3.7	1.3	-1.0	1.0	1.9	0.9	1.5	1.3	0.8	0.7	0.9	-0.8	0.9	1.6	1.1	0.6	1.6	0.6	1.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	2.0	-0.2	0.2	-0.4	-1.4	-0.2	-0.9	0.1	-0.3	-0.2	-0.3	0.3	-1.3	-0.1	-0.2	0.3	-1.2	-0.2	-0.1
Cholesterol lowering medication	1.2	1.7	3.9	-0.9	-0.5	-1.3	-0.5	-1.4	-0.1	-0.8	-1.4	-1.7	-1.6	1.6	-1.9	-0.2	-1.4	-2.0	-0.4	-1.8	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	9.0	1.9	-0.1	1.3	-0.3	1.3	3.0	1.9	1.0	0.5	0.9	-0.8	0.0	1.9	1.5	1.1	1.6	0.6	1.4
Pain experienced in last month	2.3	3.9	5.7	-2.0	-1.5	-2.4	0.2	-2.4	-1.2	-2.3	-2.3	-2.0	-2.3	2.4	0.4	-1.9	-2.3	-2.0	-2.3	-1.8	-2.0
Supplements: Calcium	0.4	0.5	2.0	0.8	0.0	0.6	1.4	0.6	0.4	1.0	0.5	0.0	0.4	-0.7	-0.4	1.0	0.6	0.5	0.5	0.7	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	2.4	0.1	1.6	0.1	0.5	0.1	-0.6	0.1	0.2	0.2	0.1	-0.2	0.5	-0.1	0.2	0.1	-0.1	0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.6	0.5	-0.4	0.5	-1.0	0.3	1.3	0.9	0.2	-0.4	0.0	-0.4	-0.0	1.0	0.4	0.0	0.1	-0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.7	-1.0	0.8	-1.4	-0.9	-1.3	-0.3	-1.4	-1.2	-1.6	-1.5	1.1	-1.0	-1.7	-1.2	-1.3	-1.6	-1.3	-1.1
Heart disease (siblings)	0.2	0.2	1.4	-0.4	0.1	-0.4	0.1	-0.4	-0.2	-0.1	-0.5	-0.4	-0.3	0.6	-1.2	-0.1	-0.4	-0.7	0.2	-0.4	-0.5
Alcohol drinker status: Previous	2.5	2.8	6.7	2.5	-0.2	1.6	0.0	1.8	2.0	1.7	1.6	1.2	1.4	-1.6	-0.0	2.0	2.0	1.7	2.6	1.9	1.8
Pack years of smoking	1.3	1.9	2.8	-1.7	-1.1	-1.5	1.0	-1.4	-0.8	-1.5	-1.5	-1.3	-1.4	1.5	-1.1	-0.9	-1.4	-1.6	-1.3	-1.4	-1.6
Impedance of whole body	0.4	1.9	4.2	-0.3	-0.5	-1.6	-1.2	-1.3	-0.8	-2.1	-1.6	-1.8	-1.6	1.8	-1.7	-1.9	-1.2	-1.1	-1.0	-0.4	-1.1
Leg fat mass (left)	0.2	0.8	4.6	-0.6	0.3	0.7	-0.4	0.5	0.5	1.5	0.8	1.3	1.0	-0.8	0.8	2.1	0.3	0.4	0.9	0.2	0.2
Arm predicted mass (left)	1.1	5.5	10.8	1.6	1.2	2.7	0.6	2.4	2.3	3.3	2.7	2.5	2.7	-2.7	0.5	3.1	2.4	2.2	2.6	1.8	2.4