[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr9:99,581,811-101,652,673

Best TWAS P=1.26e-67 · Best GWAS P=6.61e-103 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	NTR	Blood	C9orf156	0.01	0.01	lasso	5	0.01	1.5e-03	-17.3	-17.4	1.3e-67	0.59	0.42	0.25	TRUE
23	GTEx	Ovary	C9orf156	0.39	0.23	enet	15	0.18	3.9e-05	10.7	8.4	3.1e-17	-0.22	0.27	0.06	TRUE
25	GTEx	Skin Sun Exposed Lower leg	C9orf156	0.22	0.12	enet	16	0.18	1.3e-14	10.7	8.3	1.4e-16	-0.19	1.00	0.00	TRUE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FOXE1	0.13	0.08	lasso	3	0.08	7.0e-06	-3.7	-7.4	1.0e-13	0.22	0.13	0.77	TRUE
22	GTEx	Nerve Tibial	C9orf156	0.20	0.17	lasso	4	0.15	7.9e-11	10.7	7.1	1.0e-12	-0.15	1.00	0.00	TRUE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NCBP1	0.16	0.02	blup	40	0.06	1.5e-03	5.7	6.7	2.6e-11	-0.27	0.03	0.07	TRUE
15	GTEx	Cells Transformed fibroblasts	NANS	0.41	0.26	enet	20	0.28	2.6e-21	7.0	6.6	4.8e-11	-0.25	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	NANS	0.08	0.09	lasso	3	0.08	2.4e-10	5.3	5.7	1.0e-08	-0.17	1.00	0.00	TRUE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	C9orf156	0.18	0.23	lasso	4	0.23	1.9e-25	10.7	11.5	1.8e-30	-0.32	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf156	0.29	0.15	lasso	5	0.13	1.0e-12	10.7	10.9	1.0e-27	-0.30	1.00	0.00	FALSE
27	GTEx	Testis	C9orf156	0.39	0.40	enet	14	0.41	1.1e-19	10.7	10.9	1.4e-27	-0.32	1.00	0.00	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	TSTD2	0.21	0.04	enet	29	0.07	2.0e-03	-3.7	-10.8	3.6e-27	0.45	0.12	0.22	FALSE
5	GTEx	Brain Cerebellar Hemisphere	C9orf156	0.26	0.22	lasso	2	0.14	1.9e-04	10.7	10.7	1.2e-26	-0.29	0.26	0.06	FALSE
8	GTEx	Brain Frontal Cortex BA9	C9orf156	0.15	0.28	lasso	1	0.26	1.1e-07	10.7	10.7	1.2e-26	-0.29	0.50	0.06	FALSE
12	GTEx	Breast Mammary Tissue (Male)	C9orf156	0.13	-0.01	enet	1	-0.01	5.6e-01	10.7	10.7	1.2e-26	-0.29	0.05	0.06	FALSE
26	GTEx	Stomach	C9orf156	0.18	0.19	lasso	1	0.18	5.9e-09	10.7	10.7	1.2e-26	-0.29	0.98	0.00	FALSE
28	GTEx	Thyroid	C9orf156	0.21	0.26	lasso	1	0.26	7.9e-20	10.7	10.7	1.2e-26	-0.29	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C9orf156	0.07	0.03	lasso	2	0.03	2.1e-04	10.7	10.6	2.4e-26	-0.30	0.36	0.10	FALSE
7	GTEx	Brain Cortex	C9orf156	0.51	0.32	enet	11	0.29	8.1e-09	10.7	10.5	1.0e-25	-0.28	0.92	0.02	FALSE
29	METSIM	Adipose	C9orf156	0.15	0.17	lasso	5	0.17	4.3e-25	10.7	10.4	4.1e-25	-0.27	1.00	0.00	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	C9orf156	0.29	0.23	lasso	3	0.19	1.1e-06	10.1	10.2	1.9e-24	-0.31	0.74	0.03	FALSE
10	GTEx	Brain Putamen basal ganglia	C9orf156	0.27	0.24	lasso	1	0.24	2.6e-06	10.1	10.1	3.9e-24	-0.31	0.24	0.04	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C9orf156	0.03	0.03	enet	2	0.03	1.1e-04	10.1	10.1	4.2e-24	-0.31	0.07	0.39	FALSE
32	YFS	Blood	ANP32B	0.03	0.02	lasso	9	0.02	1.9e-08	1.6	-10.1	6.5e-24	0.32	0.99	0.00	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	C9orf156	0.26	0.32	lasso	3	0.30	7.9e-09	10.1	10.1	7.3e-24	-0.29	0.79	0.01	FALSE
6	GTEx	Brain Cerebellum	C9orf156	0.30	0.27	lasso	7	0.24	8.1e-08	10.1	10.0	9.5e-24	-0.26	0.89	0.01	FALSE
2	GTEx	Adipose Visceral Omentum	C9orf156	0.19	0.15	lasso	4	0.11	1.6e-06	10.7	10.0	1.2e-23	-0.27	0.91	0.00	FALSE
4	GTEx	Brain Caudate basal ganglia	C9orf156	0.40	0.40	lasso	4	0.39	3.1e-12	10.1	9.8	1.0e-22	-0.27	0.99	0.00	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C9orf156	0.12	0.03	blup	46	0.09	9.0e-05	10.7	9.7	5.2e-22	-0.26	0.26	0.42	FALSE
17	GTEx	Colon Transverse	C9orf156	0.21	0.22	lasso	4	0.20	4.5e-10	10.1	9.5	1.7e-21	-0.28	1.00	0.00	FALSE
20	GTEx	Heart Left Ventricle	C9orf156	0.23	0.18	enet	13	0.16	9.3e-09	10.7	9.3	1.8e-20	-0.23	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C9orf156	0.31	0.12	enet	7	0.11	3.4e-05	10.7	9.3	2.1e-20	-0.25	0.22	0.09	FALSE
11	GTEx	Breast Mammary Tissue	C9orf156	0.30	0.20	enet	16	0.21	3.3e-11	10.1	8.9	4.1e-19	-0.25	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue (Female)	C9orf156	0.42	0.22	lasso	10	0.23	1.5e-07	10.7	8.6	5.7e-18	-0.22	0.49	0.03	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	C9orf156	0.16	0.11	lasso	2	0.10	5.1e-06	10.7	8.1	6.3e-16	-0.19	0.74	0.01	FALSE
16	GTEx	Colon Sigmoid	C9orf156	0.19	0.17	lasso	5	0.15	7.4e-06	10.1	7.9	2.1e-15	-0.22	0.51	0.03	FALSE
33	YFS	Blood	CORO2A	0.03	0.01	bslmm	606	0.01	1.4e-04	1.0	-7.7	1.0e-14	0.22	0.13	0.04	FALSE
3	GTEx	Artery Coronary	TMOD1	0.18	0.01	enet	11	0.11	1.8e-04	-0.8	-7.0	2.1e-12	0.29	0.07	0.15	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	NANS	0.06	0.03	lasso	3	0.03	5.1e-04	7.0	6.4	1.3e-10	-0.26	0.21	0.39	FALSE
19	GTEx	Esophagus Mucosa	TMOD1	0.12	0.04	enet	21	0.05	3.7e-04	4.6	6.3	2.4e-10	-0.21	0.21	0.04	FALSE
21	GTEx	Muscle Skeletal	C9orf156	0.35	0.23	lasso	9	0.25	7.5e-25	10.1	6.3	3.3e-10	-0.15	1.00	0.00	FALSE
30	METSIM	Adipose	TMOD1	0.04	0.04	enet	12	0.03	2.7e-05	5.9	-5.4	7.3e-08	0.13	0.74	0.01	FALSE