Hub : Genes

NANS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.083 0.027 1.8e-04 0.088 0.014 0.078 0.051 0.083 6.7e-11 0.0077 9.7e-10 7.2e-07 2.5e-10
2 GTEx Cells Transformed fibroblasts 0.409 0.062 5.0e-14 0.258 NA 0.282 NA 0.279 2.2e-19 NA 2.6e-21 NA 4.7e-21
3 GTEx Testis 0.385 0.085 2.2e-06 0.154 NA 0.151 NA 0.128 2.4e-07 NA 3.3e-07 NA 2.6e-06
4 TCGA Thyroid Carcinoma 0.060 0.032 5.3e-04 0.035 0.025 0.003 NA 0.031 2.4e-04 0.0015 1.4e-01 NA 5.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.2 3.6 8.9 -3.0 -1.0 -1.9 -0.8
Bipolar Disorder or Schizophrenia 1.5 3.7 6.3 -2.5 -1.8 -1.4 -1.8
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 -0.2 -0.0 -0.1 0.3
Depression (Nagel 2018) 0.5 0.7 1.5 0.6 -1.2 0.6 -0.8
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.8 1.7 -0.0 -0.2 0.3
Neuroticism (Nagel 2018) 0.4 0.9 1.9 0.7 0.9 0.7 1.4
Schizophrenia (2018) 0.7 1.4 2.7 -0.8 -1.5 -0.3 -1.6
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 0.5 -0.5 0.0 -0.7
Worry (Nagel 2018) 0.2 0.5 0.8 0.9 0.2 0.8 0.6
Alzheimer’s Disease (in mother) 0.2 0.3 0.4 -0.6 -0.5 -0.1 -0.6
Alzheimer’s Disease (in father) 0.7 0.8 1.0 0.9 0.4 1.0 1.0
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 -0.5 -0.2 0.1 -0.1
Crohns Disease (2017) 0.1 0.1 0.2 -0.4 -0.1 0.3 0.5
Irritable Bowel Disease (IBD) 0.5 1.1 2.3 -0.4 1.3 -0.1 1.5
Ulcerative Colitis (UC) 0.9 1.7 3.6 0.1 1.9 -0.1 1.7
Major Depression (MDD) 0.7 0.9 1.8 -1.3 0.4 -1.1 0.4
Reaction Time 0.4 0.9 1.8 -1.3 -0.5 -0.7 -1.0
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.4 0.3 0.0 -1.2 0.2
Breast Cancer 0.5 1.3 2.3 -0.5 1.4 -0.8 1.5
Ovarian Cancer 0.5 0.7 1.9 -1.4 0.5 -0.9 0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 0.9 0.4 0.9 -0.1 0.4
Bipolar Disorder (2011) 2.7 2.6 6.6 -2.6 -0.4 -1.9 -0.4
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 -0.2 -1.0 -0.6 -0.6
Coronary Artery Disease (CAD) 1.8 2.2 4.4 -0.5 2.1 -0.6 1.9
Crohns Disease (2012) 0.1 0.2 0.4 -0.6 0.2 -0.2 0.5
Mean Putamen Volume 0.2 0.3 0.5 -0.7 0.3 -0.6 -0.2
Fasting Glucose 0.4 0.5 1.5 -1.2 -0.5 -0.3 -0.4
HbA1C 0.3 0.4 0.9 -1.0 -0.6 0.3 0.2
HDL Cholesterol 0.6 1.0 2.7 -1.6 0.3 -1.0 0.7
LDL Cholesterol 0.1 0.2 0.6 0.0 0.3 -0.8 0.2
Lupus 1.1 1.7 2.8 -0.4 1.5 -1.2 1.7
Neuroticism (2016) 1.7 2.4 3.3 1.8 1.5 1.0 1.8
Primary Biliary Cirrhosis 1.1 1.6 2.3 -1.2 1.3 -1.0 1.5
Rheumatoid Arthritis 0.4 0.6 1.5 0.2 -0.7 0.5 -1.2
Schizophrenia (2014) 1.2 2.6 3.4 -1.7 -1.6 -1.1 -1.9
Triglycerides 0.1 0.2 0.4 -0.2 0.0 -0.7 -0.5
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 -0.1 -0.0 0.0 -0.1
Ulcerative Colitis 1.3 1.9 4.4 0.1 2.1 -0.1 1.8
Blood Eosinophil Count 1.6 12.1 18.8 0.4 -4.3 3.3 -4.3
Blood Platelet Count 5.2 59.7 110.2 5.6 9.9 0.3 10.5
Blood Red Count 4.6 44.5 80.8 6.2 -5.7 9.0 -5.1
Blood White Count 1.0 7.6 13.6 0.2 -3.7 1.9 -3.6
Heel T-Score 0.6 4.9 9.4 2.2 -1.2 3.1 -1.9
BMI 0.4 2.5 4.3 -2.1 -2.0 -0.9 -1.1
Height 0.7 13.4 20.9 -4.6 2.7 -4.1 2.9
Waist Hip Ratio (WHR) 0.8 3.6 6.3 -0.4 -2.5 1.2 -2.5
Systolic Blood Pressure 0.1 0.4 0.8 -0.9 -0.1 -0.6 -0.7
Smoking Status 0.6 1.5 2.1 -1.5 1.2 -1.3 0.9
Allergy or Eczema 0.3 0.9 2.5 -1.6 -0.1 -1.1 -0.0
Cardiovascular Disease 0.8 2.5 4.0 -2.0 -1.5 0.2 -1.9
Hypothyroidism (self reported) 12.9 29.6 43.3 5.7 6.6 1.1 6.4
Respiratory disease 1.3 2.8 4.4 -1.2 -2.1 1.4 -1.9
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.6 0.2 -0.8 1.6 -0.9
Lung FEV1/FVC ratio 1.2 6.0 17.5 -4.2 0.8 -2.4 0.5
Lung FVC 0.3 1.4 3.2 0.3 1.4 -0.7 1.8
Neuroticism 0.3 0.6 1.8 0.7 0.5 0.2 1.4
Chronotype (morning person) 0.4 1.0 1.8 -1.3 1.0 -0.5 1.0
Hair Pigment 0.4 10.9 23.4 4.8 2.2 3.7 1.2
Tanning 0.1 1.2 3.0 -0.5 1.3 0.1 1.7
Hand grip strength (left) 3.1 8.2 15.8 1.1 3.7 -1.4 4.0
Number of treatments/medications taken 0.2 0.4 1.0 -0.3 -0.7 0.5 -1.0
Average weekly spirits intake 1.2 1.5 3.1 1.5 0.4 1.8 0.7
Sensitivity / hurt feelings 2.4 4.2 8.8 1.5 2.3 0.6 3.0
Frequency of depressed mood in last 2 weeks 2.3 3.2 5.4 2.2 -1.4 2.3 -0.9
Hearing difficulty/problems: Yes 0.6 0.9 2.9 0.9 -0.1 1.7 -0.0
Relative age of first facial hair 0.1 0.3 0.6 0.2 -0.1 0.7 -0.7
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 -0.1 0.6 0.3 0.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.6 -1.6 -0.6 -0.2 -0.8
Ever had hysterectomy (womb removed) 1.5 1.7 3.4 0.4 1.7 0.4 1.9
Systolic blood pressure, automated reading 0.2 0.5 0.9 -1.0 -0.5 -0.2 -0.8
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.2 -1.5 0.0 -0.6 -0.2
Angina 0.5 0.7 1.0 -0.7 -0.8 1.0 -0.8
Medication for hormone replacement therapy 0.5 0.5 1.1 -0.9 -0.5 -1.0 -0.2
Vitamin and mineral supplements 1.7 2.3 5.9 -0.6 -1.7 0.1 -2.4
Supplements: Zinc 4.6 5.0 9.5 1.4 2.9 0.4 3.1
Medication: Co-codamol 1.1 1.3 1.9 -0.9 -1.4 0.7 -1.4
Medication: Metformin 1.2 1.7 5.3 0.9 -0.5 2.3 -0.7
Diabetes (father) 0.2 0.2 0.8 0.1 -0.2 -0.1 -0.9
Diabetes (mother) 1.3 1.6 3.7 -0.7 -0.8 1.3 -1.9
Severe depression (siblings) 1.4 1.6 2.7 -0.5 1.2 -1.7 1.4
Pack years adult smoking proportion 0.5 0.8 1.7 -1.3 0.1 -1.2 -0.1
Impedance of leg (right) 0.2 0.9 1.5 0.8 1.2 -0.6 1.0
Leg fat-free mass (left) 0.6 3.0 8.2 -2.9 -0.7 -1.8 -0.3
Trunk fat percentage 1.4 5.8 12.2 -3.5 -1.9 -2.2 -1.5
Hand grip strength (right) 1.3 3.5 6.3 -0.1 2.5 -1.7 2.2
Townsend deprivation index at recruitment 0.3 0.5 1.1 -0.4 -1.0 0.1 -0.9
Current tobacco smoking 0.4 0.7 1.9 -0.9 0.3 -1.4 -0.2
Average weekly fortified wine intake 1.7 2.0 3.7 -0.7 -1.9 0.0 -1.9
Maternal smoking around birth 0.7 1.0 2.5 -1.1 -0.2 -1.6 0.3
Fed-up feelings 0.1 0.2 0.4 0.5 0.2 -0.1 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 5.8 0.3 -2.4 0.6 -1.9
Relative age voice broke 0.3 0.4 1.1 -0.8 -0.1 -0.2 -1.1
Taking other prescription medications 0.6 0.9 1.7 0.9 0.8 1.3 0.6
Age when periods started (menarche) 1.3 3.0 3.9 0.9 -2.0 1.9 -2.0
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.4 -0.3 1.1 -0.5 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.8 0.2 -1.4 0.7 -1.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.2 -0.5 0.2 1.1 -0.1
Qualifications: CSEs or equivalent 1.5 2.0 5.8 2.4 0.4 0.2 1.4
Serious illness, injury or assault to yourself 1.8 2.2 4.2 0.3 2.0 -0.5 2.0
High blood pressure 0.8 2.2 3.0 -1.7 -1.6 0.2 -1.7
Hayfever, allergic rhinitis or eczema 1.0 2.2 4.6 -2.1 0.5 -1.8 0.7
Multivitamins +/- minerals 3.6 4.6 9.9 1.8 2.1 0.9 3.1
Stomach or abdominal pain in last month 0.6 0.7 2.0 -0.0 -1.4 0.2 -0.9
Supplements: Glucosamine 0.9 1.2 3.2 -0.3 1.1 -0.3 1.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 0.9 -1.1 0.4 -0.6
Medication: Atenolol 0.6 0.7 1.4 -1.2 0.2 -0.5 -1.1
Medication: Levothyroxine sodium 7.0 11.8 20.0 4.5 3.5 1.5 3.5
Sitting height 1.3 9.4 11.1 -2.6 3.0 -3.3 3.3
Chronic bronchitis/emphysema (father) 0.4 0.5 1.0 -0.0 -1.0 0.5 -0.9
High blood pressure (mother) 0.6 0.8 1.5 0.8 1.2 0.5 1.0
Body mass index (BMI) 1.2 5.1 8.1 -2.6 -2.8 -0.8 -2.1
Impedance of leg (left) 0.3 1.7 3.2 1.0 1.8 -0.5 1.5
Leg predicted mass (left) 0.6 3.2 9.1 -3.0 -0.7 -1.8 -0.3
Trunk fat mass 1.4 5.8 13.9 -3.7 -1.7 -2.3 -1.2
Waist circumference 1.6 6.0 8.5 -2.9 -2.9 -1.1 -2.4
Number of incorrect matches in round 0.9 1.4 3.2 -1.8 -0.9 -0.8 -0.9
Past tobacco smoking 0.3 0.5 0.9 0.6 -0.8 -0.5 -0.9
Alcohol usually taken with meals 1.3 2.1 3.9 0.1 1.7 -1.2 2.0
Nervous feelings 0.2 0.4 0.5 -0.6 -0.7 0.6 -0.6
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.3 4.3 2.0 -2.1 1.8 -1.3
Hearing difficulty/problems with background noise 1.5 2.5 6.7 1.8 0.2 2.6 0.0
Hair/balding pattern: Pattern 2 0.9 1.1 1.6 1.3 -1.0 0.5 -1.2
Had menopause 2.8 3.5 8.8 -1.3 1.2 -3.0 1.5
Had other major operations 0.7 0.9 1.4 -0.5 1.2 -1.1 0.9
Forced vital capacity (FVC) 1.4 5.6 11.4 -0.4 3.0 -1.3 3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 0.1 -0.8 0.4 -1.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 0.3 0.5 -1.1 0.7
Qualifications: None of the above 0.2 0.4 0.5 -0.7 -0.6 0.7 -0.5
Financial difficulties in last 2 years 0.6 0.8 1.4 0.2 -1.2 0.8 -1.0
Mouth/teeth dental problems 0.5 0.7 1.6 -1.3 -0.3 -0.8 -0.7
Heart attack 0.9 1.1 1.8 -0.9 0.9 -1.3 1.1
Allergy 0.8 1.8 5.1 2.2 -0.3 1.3 -0.6
Pain all over the body in last month 0.9 0.9 1.6 0.8 1.3 -0.3 1.2
Diabetes (self-reported) 1.2 1.9 5.2 0.0 -0.9 2.3 -1.2
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.3 -1.8 -0.3 -1.1 -0.7
Medication: Ramipril 2.7 3.4 6.8 -1.0 -2.4 0.2 -2.6
Medication: Simvastatin 0.4 0.5 1.4 -1.2 -0.5 0.5 -0.5
Fluid intelligence score 0.7 1.4 2.1 0.0 1.3 -1.3 1.5
Illnesses of siblings 0.2 0.3 0.7 -0.6 -0.2 -0.8 -0.3
Neuroticism score 0.1 0.3 0.6 0.7 0.1 0.2 0.8
Weight 0.9 4.6 12.4 -3.5 -1.3 -2.1 -0.5
Impedance of arm (right) 0.5 2.4 4.1 1.1 2.0 -0.5 2.0
Arm fat percentage (right) 0.9 3.7 6.8 -2.6 -2.1 -1.3 -1.4
Trunk fat-free mass 0.2 1.3 3.6 -1.9 0.1 -1.0 0.7
Hip circumference 0.7 2.9 4.9 -2.2 -1.9 -1.1 -1.4
Time employed in main current job 1.3 1.5 3.0 1.0 -1.1 1.7 -0.9
Alcohol intake versus 10 years previously 0.8 1.2 1.6 1.2 0.9 0.9 1.3
Father’s age at death 0.6 0.8 2.0 -0.0 -1.1 -0.0 -1.4
Worrier / anxious feelings 0.2 0.4 1.1 0.5 0.3 1.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.5 1.9 1.0 -0.3 1.3
Falls in the last year 0.5 0.6 1.4 -0.1 1.2 -0.1 1.0
Hair/balding pattern: Pattern 3 4.0 5.9 10.6 -3.2 1.6 -2.8 1.6
Number of live births 0.3 0.4 1.0 1.0 -0.2 -0.5 0.3
Forced expiratory volume in 1-second (FEV1) 1.6 5.4 10.3 -0.9 2.9 -1.4 3.2
Pulse rate 0.9 1.5 3.8 -2.0 -0.7 -0.8 -1.1
Happiness 4.2 5.1 11.5 -3.4 0.2 -2.9 -0.6
Noisy workplace 0.3 0.4 0.7 0.7 0.6 0.9 0.1
Qualifications: A levels/AS levels or equivalent 2.5 5.6 9.5 0.4 3.0 -1.9 3.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.0 0.3 1.0 0.9 0.9
Mouth/teeth dental problems: Dentures 0.0 0.1 0.1 0.3 0.1 0.4 0.0
Asthma 1.0 2.0 3.7 -1.9 -1.6 -0.0 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.9 0.9 0.0 -0.1 0.2
Medication: Cholesterol lowering 0.2 0.3 0.7 -0.8 0.5 0.3 0.3
Depression (self-reported) 0.2 0.3 0.6 0.1 0.7 0.2 0.8
Medication: Lansoprazole 1.3 1.5 4.0 2.0 -0.2 1.3 0.4
Prospective memory result 1.0 1.3 2.3 -1.5 -1.1 -0.7 -1.1
Lung cancer (father) 2.7 3.2 7.5 0.0 -2.7 0.2 -2.3
Illnesses of mother 0.3 0.3 1.0 -0.0 0.3 -0.4 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.5 10.0 -1.2 3.1 -2.3 3.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 0.5 1.0 0.0 0.8
Impedance of arm (left) 0.3 1.3 2.2 0.7 1.5 -0.7 1.3
Arm fat mass (right) 1.1 4.5 9.1 -3.0 -2.2 -1.4 -1.4
Trunk predicted mass 0.2 1.3 3.8 -1.9 0.1 -0.9 0.7
Standing height 0.9 9.0 11.7 -2.2 3.2 -3.1 3.4
Length of working week for main job 0.4 0.5 0.9 -0.3 -0.7 -0.6 -0.9
Exposure to tobacco smoke at home 4.8 5.4 8.6 -2.9 -2.1 -0.6 -2.9
Breastfed as a baby 1.8 2.3 3.4 1.6 1.4 1.1 1.9
Tense / ‘highly strung’ 0.3 0.5 1.6 0.6 0.2 1.2 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.1 0.1 -0.6 1.0 -0.9
Hair/balding pattern: Pattern 4 2.1 5.0 9.3 1.3 3.0 -0.2 3.0
Birth weight of first child 1.2 2.1 5.2 2.3 0.8 1.2 1.2
Peak expiratory flow (PEF) 5.2 12.1 25.2 -0.1 4.7 -1.3 5.0
Pulse wave reflection index 2.8 3.5 7.9 2.8 1.2 1.7 1.3
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.5 -0.1 -0.2 -0.3
Loud music exposure frequency 1.1 1.2 3.8 1.9 0.7 0.7 0.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 4.1 0.3 1.7 -0.4 2.0
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 5.4 2.3 0.2 0.9 1.0
Blood clot in the leg (DVT) 0.7 0.8 1.7 -0.7 1.1 0.0 1.3
Medication: Paracetamol 0.3 0.5 1.6 1.3 -0.0 0.7 0.2
Headache pain in last month 2.6 4.5 7.2 2.0 -1.9 2.7 -1.8
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.8 1.0 1.0 -1.4 1.0
Glaucoma (self-reported) 0.5 0.6 1.3 -0.2 1.1 -0.8 0.6
Gout (self-reported) 2.2 3.1 6.3 1.7 1.7 -0.2 2.5
Hypothyroidism/myxoedema (self-reported) 8.9 17.3 25.9 4.4 5.1 1.1 4.8
Medication: Amlodipine 1.0 1.4 2.1 -0.8 -1.5 1.1 -1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 -0.2 0.9 -0.3 0.8
Birth weight 0.8 1.7 3.6 1.0 1.9 -0.6 1.3
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.5 0.3 -1.5 0.3 -1.6
High blood pressure (siblings) 0.2 0.2 0.5 -0.7 0.3 0.5 0.2
Forced vital capacity (FVC), Best measure 1.4 5.3 9.1 -0.5 2.9 -1.8 3.0
Body fat percentage 1.4 5.4 10.6 -3.2 -2.1 -2.0 -1.6
Leg fat percentage (right) 1.0 3.7 5.3 -2.3 -2.3 -1.2 -1.7
Arm fat-free mass (right) 0.6 3.0 9.3 -3.0 -0.9 -1.3 -0.5
Exposure to tobacco smoke outside home 0.3 0.4 0.9 1.0 0.2 0.3 0.8
Comparative body size at age 10 0.2 0.6 1.6 0.6 -0.7 -1.3 -0.1
Number of full brothers 0.3 0.4 1.0 0.7 0.4 -0.0 1.0
Worry too long after embarrassment 0.7 1.2 1.4 1.2 1.1 1.0 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.5 -0.6 -0.7 -0.0 -0.7
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 -0.6 0.1 0.3 0.6
Number of children fathered 0.1 0.2 0.3 -0.6 0.2 -0.5 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.5 -1.2 -0.8 -0.9 -0.6
Age at first live birth 1.4 2.4 3.6 1.6 1.9 1.2 1.5
Pulse wave peak to peak time 0.3 0.4 0.7 -0.6 -0.9 -0.2 -0.6
Health satisfaction 0.2 0.3 0.8 -0.3 -0.9 -0.1 -0.6
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.1 -0.5 -0.0 -0.3
Qualifications: College or University degree 0.2 0.8 1.6 1.3 0.6 1.0 0.2
Eye problems/disorders: None of the above 0.5 0.5 1.1 -0.4 0.7 -0.6 1.1
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 -0.2 0.3 0.7 0.7
Emphysema/chronic bronchitis 2.4 2.7 5.6 2.1 -0.8 2.4 -0.4
Medication for pain relief, constipation, heartburn 1.1 2.0 5.5 -1.4 0.5 -2.3 0.2
Neck or shoulder pain in last month 1.5 2.2 4.6 0.5 1.6 -1.2 2.1
Medication: Blood pressure 0.6 1.1 2.3 -1.5 -0.8 0.6 -1.1
Angina (self-reported) 0.6 0.8 1.3 -1.2 -0.8 0.6 -0.9
Migraine (self-reported) 1.8 2.2 3.6 1.3 1.9 0.7 1.8
Medication: Ibuprofen 0.2 0.2 0.6 0.8 -0.0 -0.2 0.3
Medication: Allopurinol 0.7 0.9 2.1 -0.1 1.1 -0.7 1.4
Medication: Omeprazole 0.6 0.7 0.8 0.9 0.8 0.9 0.7
Medication: Seretide 50 evohaler 0.7 0.8 2.3 -0.1 -0.8 1.5 -0.5
Mean time to correctly identify matches 0.7 1.3 2.4 -1.5 -0.8 -0.6 -1.3
Heart disease (mother) 0.5 0.5 1.3 0.5 1.1 0.2 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.1 3.7 5.9 1.6 2.2 1.2 2.4
Whole body fat mass 1.4 5.8 12.7 -3.6 -2.1 -2.1 -1.4
Leg fat mass (right) 1.4 5.4 10.6 -3.3 -2.2 -1.9 -1.6
Arm predicted mass (right) 0.5 2.7 8.3 -2.9 -0.8 -1.4 -0.3
Pulse rate, automated reading 0.3 1.1 2.3 -1.5 -0.4 0.6 -1.1
Alcohol intake frequency. 1.8 4.2 9.3 -0.6 -2.7 -0.1 -3.0
Comparative height size at age 10 1.9 10.3 15.9 -3.2 2.7 -4.0 2.8
Number of full sisters 0.6 0.7 1.6 -1.2 -0.0 0.5 -1.0
Suffer from ‘nerves’ 0.4 0.7 2.4 1.6 -0.1 0.3 0.4
Overall health rating 0.7 1.4 2.1 -1.4 -1.4 0.4 -1.3
Chest pain or discomfort 0.1 0.2 0.4 -0.6 -0.6 0.1 -0.2
Had major operations 1.5 1.8 4.5 1.3 -0.5 2.1 -0.9
Age at last live birth 2.2 3.2 6.7 2.6 1.8 0.8 1.5
Family relationship satisfaction 0.1 0.2 0.4 -0.2 -0.3 -0.7 0.0
Leg pain on walking 0.3 0.4 1.3 -0.0 -0.2 1.2 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.9 4.2 -2.1 -0.7 -1.2 -1.1
Commuting to job workplace: Car/motor vehicle 1.4 1.6 2.5 0.0 -1.6 1.4 -1.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 -1.1 -0.6 -0.5 -0.6
Medication: Aspirin 0.5 0.6 1.9 0.3 0.5 1.4 0.6
Supplements: Vitamin C 0.8 1.0 2.2 0.3 1.2 -0.3 1.5
Knee pain experienced in last month 1.0 1.6 3.5 -0.1 1.9 -0.5 1.7
Hypertension (Self-reported) 0.5 1.5 2.1 -1.4 -1.4 -0.2 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.5 5.3 9.6 1.3 3.1 0.7 3.1
Illnesses of father: Heart disease 0.9 1.3 2.7 -0.6 1.3 -0.6 1.6
Illnesses of siblings: Diabetes 1.0 1.2 3.4 1.8 0.1 1.0 0.5
Smoking status: Previous 0.3 0.4 0.8 -0.4 0.6 0.7 0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.3 5.2 -0.2 2.3 -2.1 1.9
Whole body fat-free mass 0.4 2.0 6.1 -2.5 -0.2 -1.4 0.3
Leg fat-free mass (right) 0.4 2.4 6.9 -2.6 -0.3 -1.6 0.2
Arm fat percentage (left) 1.2 4.6 7.6 -2.8 -2.4 -1.3 -1.8
Average weekly red wine intake 0.1 0.2 0.7 -0.8 -0.3 0.1 -0.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 0.5 0.8 0.3 0.9
Mood swings 0.2 0.3 0.8 0.4 -0.9 0.2 -0.3
Loneliness, isolation 0.5 0.7 2.0 -0.2 -0.9 0.1 -1.4
Long-standing illness, disability or infirmity 0.1 0.1 0.2 -0.5 0.2 -0.4 0.0
Ever had bowel cancer screening 2.6 3.1 4.9 2.2 1.7 0.4 2.1
Diabetes diagnosed by doctor 1.1 1.8 5.8 0.2 -0.7 2.4 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.2 4.1 -0.1 1.6 -1.5 2.0
Friendships satisfaction 1.0 1.2 2.8 -1.4 0.3 -1.7 0.2
Qualifications: nursing, teaching 0.3 0.5 1.2 -0.0 1.1 -0.2 0.7
Commuting to job workplace: Walk 4.2 4.6 6.7 2.6 1.9 1.2 2.5
Eye problems/disorders: Cataract 0.7 0.8 1.3 1.2 0.7 1.1 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.4 0.5 0.7 0.3 0.6
Medication for cholesterol 1.6 2.4 3.5 1.9 1.5 1.3 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.4 0.1 -1.2 0.6 -0.7
Back pain experienced in last month 0.7 1.0 2.0 0.4 -1.2 1.4 -0.5
Mineral and other dietary supplements 1.6 2.1 5.1 -0.5 -1.7 -0.0 -2.3
Breast cancer (self-reported) 1.6 1.9 3.0 1.7 1.5 1.2 0.9
Asthma (self-reported) 1.4 2.7 4.8 -2.2 -1.9 -0.1 -1.6
Osteoporosis (self-reported) 0.2 0.3 0.9 -0.3 -0.1 -0.5 -0.9
Osteoarthritis (self-reported) 1.4 1.8 3.5 -0.6 1.9 -0.9 1.6
Medication: Aspirin 0.3 0.3 1.4 -0.0 0.1 1.2 0.1
Medication: Gliclazide 1.6 1.8 2.6 -0.1 -1.6 1.5 -1.5
Illnesses of father: None of the above (group 1) 0.4 0.5 1.1 0.5 0.7 0.1 1.1
Smoking status: Current 0.7 1.1 2.5 -1.3 0.1 -1.6 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.4 0.0 1.1 -0.7 1.2
Whole body water mass 0.3 1.9 5.8 -2.4 -0.3 -1.2 0.3
Leg predicted mass (right) 0.4 2.4 6.8 -2.6 -0.3 -1.6 0.2
Arm fat mass (left) 1.2 4.9 9.6 -3.1 -2.3 -1.6 -1.5
Number of self-reported non-cancer illnesses 0.3 0.5 1.3 0.6 0.7 1.1 0.4
Average weekly champagne plus white wine intake 0.0 0.0 0.0 -0.1 -0.2 0.2 -0.2
Miserableness 0.6 1.0 2.2 -0.3 1.2 -0.7 1.5
Guilty feelings 1.1 1.7 3.4 0.0 1.8 -0.6 1.8
Wears glasses or contact lenses 0.1 0.1 0.1 -0.2 -0.4 -0.2 -0.4
Ever taken oral contraceptive pill 2.0 2.2 5.1 1.8 -0.5 2.2 -0.5
Hearing aid user 1.4 1.6 2.5 0.6 -1.5 1.1 -1.6
Mother’s age at death 0.9 1.2 3.6 1.9 0.8 0.2 0.6
Financial situation satisfaction 0.9 1.2 3.3 -1.8 -0.3 -1.1 -0.0
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.3 1.1 0.4 1.0 0.2
Commuting to job workplace: Public transport 0.9 1.0 2.0 0.3 1.2 -0.8 1.4
Eye problems/disorders: Glaucoma 0.3 0.3 1.1 -0.2 -0.0 -1.0 -0.3
Medication: Blood pressure 2.2 4.1 6.3 -2.5 -1.7 -1.7 -2.1
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.6 -0.8 -0.0 -0.5 -0.0
Supplements: Fish oil (including cod liver oil) 2.1 2.8 5.6 0.5 2.3 -0.0 2.4
High cholesterol (Self-reported) 0.5 0.8 2.1 -0.8 1.4 0.2 0.8
Medication: Bendroflumethiazide 0.7 1.1 2.5 -0.3 -1.4 -0.3 -1.6
Medication: Paracetamol 0.4 0.6 1.2 1.1 0.6 0.4 0.8
Medication: Lisinopril 0.4 0.5 1.2 0.2 -1.1 0.7 -0.5
Medication: Atorvastatin 0.3 0.4 0.7 -0.8 0.3 -0.8 0.2
Illnesses of father: High blood pressure 0.2 0.2 0.3 0.4 -0.5 0.5 -0.4
Alcohol drinker status: Never 1.8 2.2 3.5 -1.3 -1.9 -0.9 -1.6
Ever smoked 0.3 0.5 1.0 -0.1 0.9 0.4 1.0
Basal metabolic rate 0.5 2.5 7.5 -2.7 -0.5 -1.5 0.1
Leg fat percentage (left) 0.9 3.1 4.8 -2.1 -2.2 -0.9 -1.6
Arm fat-free mass (left) 0.4 2.0 6.4 -2.5 -0.5 -1.2 0.0
Number of operations (self-reported) 0.7 1.1 2.8 0.7 -0.8 1.7 -0.6
Average weekly beer plus cider intake 0.4 0.6 1.0 0.9 -1.0 0.1 -0.6
Irritability 0.2 0.3 0.8 0.9 -0.5 0.5 0.3
Risk taking 0.7 1.1 2.0 0.6 -1.4 0.4 -1.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 -0.1 -0.7 -0.1 -0.5
Fractured/broken bones in last 5 years 0.2 0.3 0.4 0.5 0.6 -0.2 0.7
Age started oral contraceptive pill 0.0 0.1 0.2 0.2 -0.0 -0.2 -0.4
Diastolic blood pressure, automated reading 0.1 0.3 0.8 -0.1 -0.5 0.9 -0.2
Ever depressed for a whole week 0.4 0.5 1.1 -0.1 1.1 -0.5 0.6
Unable to work because of sickness or disability 0.3 0.4 0.9 -0.1 -0.5 0.9 -0.6
Commuting to job workplace: Cycle 2.2 2.6 5.5 0.2 2.2 -0.4 2.3
Myopia 3.6 5.2 11.5 3.0 0.0 3.4 0.2
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.0 1.4 1.4 -0.3 1.4
Cholesterol lowering medication 0.2 0.2 0.7 -0.8 -0.1 -0.5 0.0
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 3.1 1.8 1.2 1.3 1.4
Pain experienced in last month 0.3 0.6 1.1 -1.0 0.0 -1.1 -0.4
Supplements: Calcium 1.9 2.1 3.9 0.1 -2.0 1.4 -1.6
Basal cell carcinoma (self-reported) 0.4 0.4 0.8 -0.2 0.9 -0.3 0.9
Heart attack/myocardial infarction (self-reported) 0.6 0.7 1.2 -0.9 0.6 -1.1 0.8
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.1 -0.9 1.0 0.0 1.1
Heart disease (siblings) 1.1 1.4 3.8 -1.9 -0.4 -1.1 -0.7
Alcohol drinker status: Previous 0.9 1.0 1.8 0.3 -0.6 1.4 -1.3
Pack years of smoking 0.3 0.5 0.9 -0.9 0.4 -0.9 0.2
Impedance of whole body 0.4 1.9 3.5 0.7 1.9 -1.0 1.6
Leg fat mass (left) 1.3 5.0 10.0 -3.2 -2.2 -1.7 -1.6
Arm predicted mass (left) 0.5 2.4 7.8 -2.8 -0.7 -1.2 -0.1