Hub : Genes

NANS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.083	0.027	1.8e-04	0.088	0.014	0.078	0.051	0.083	6.7e-11	0.0077	9.7e-10	7.2e-07	2.5e-10
2	GTEx	Cells Transformed fibroblasts	0.409	0.062	5.0e-14	0.258	NA	0.282	NA	0.279	2.2e-19	NA	2.6e-21	NA	4.7e-21
3	GTEx	Testis	0.385	0.085	2.2e-06	0.154	NA	0.151	NA	0.128	2.4e-07	NA	3.3e-07	NA	2.6e-06
4	TCGA	Thyroid Carcinoma	0.060	0.032	5.3e-04	0.035	0.025	0.003	NA	0.031	2.4e-04	0.0015	1.4e-01	NA	5.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.2	3.6	8.9	-3.0	-1.0	-1.9	-0.8
Bipolar Disorder or Schizophrenia	1.5	3.7	6.3	-2.5	-1.8	-1.4	-1.8
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.3
Depression (Nagel 2018)	0.5	0.7	1.5	0.6	-1.2	0.6	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.8	1.7	-0.0	-0.2	0.3
Neuroticism (Nagel 2018)	0.4	0.9	1.9	0.7	0.9	0.7	1.4
Schizophrenia (2018)	0.7	1.4	2.7	-0.8	-1.5	-0.3	-1.6
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.5	-0.5	0.0	-0.7
Worry (Nagel 2018)	0.2	0.5	0.8	0.9	0.2	0.8	0.6
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	-0.6	-0.5	-0.1	-0.6
Alzheimer’s Disease (in father)	0.7	0.8	1.0	0.9	0.4	1.0	1.0
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.5	-0.2	0.1	-0.1
Crohns Disease (2017)	0.1	0.1	0.2	-0.4	-0.1	0.3	0.5
Irritable Bowel Disease (IBD)	0.5	1.1	2.3	-0.4	1.3	-0.1	1.5
Ulcerative Colitis (UC)	0.9	1.7	3.6	0.1	1.9	-0.1	1.7
Major Depression (MDD)	0.7	0.9	1.8	-1.3	0.4	-1.1	0.4
Reaction Time	0.4	0.9	1.8	-1.3	-0.5	-0.7	-1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.4	0.3	0.0	-1.2	0.2
Breast Cancer	0.5	1.3	2.3	-0.5	1.4	-0.8	1.5
Ovarian Cancer	0.5	0.7	1.9	-1.4	0.5	-0.9	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	0.9	0.4	0.9	-0.1	0.4
Bipolar Disorder (2011)	2.7	2.6	6.6	-2.6	-0.4	-1.9	-0.4
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.2	-1.0	-0.6	-0.6
Coronary Artery Disease (CAD)	1.8	2.2	4.4	-0.5	2.1	-0.6	1.9
Crohns Disease (2012)	0.1	0.2	0.4	-0.6	0.2	-0.2	0.5
Mean Putamen Volume	0.2	0.3	0.5	-0.7	0.3	-0.6	-0.2
Fasting Glucose	0.4	0.5	1.5	-1.2	-0.5	-0.3	-0.4
HbA1C	0.3	0.4	0.9	-1.0	-0.6	0.3	0.2
HDL Cholesterol	0.6	1.0	2.7	-1.6	0.3	-1.0	0.7
LDL Cholesterol	0.1	0.2	0.6	0.0	0.3	-0.8	0.2
Lupus	1.1	1.7	2.8	-0.4	1.5	-1.2	1.7
Neuroticism (2016)	1.7	2.4	3.3	1.8	1.5	1.0	1.8
Primary Biliary Cirrhosis	1.1	1.6	2.3	-1.2	1.3	-1.0	1.5
Rheumatoid Arthritis	0.4	0.6	1.5	0.2	-0.7	0.5	-1.2
Schizophrenia (2014)	1.2	2.6	3.4	-1.7	-1.6	-1.1	-1.9
Triglycerides	0.1	0.2	0.4	-0.2	0.0	-0.7	-0.5
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.1
Ulcerative Colitis	1.3	1.9	4.4	0.1	2.1	-0.1	1.8
Blood Eosinophil Count	1.6	12.1	18.8	0.4	-4.3	3.3	-4.3
Blood Platelet Count	5.2	59.7	110.2	5.6	9.9	0.3	10.5
Blood Red Count	4.6	44.5	80.8	6.2	-5.7	9.0	-5.1
Blood White Count	1.0	7.6	13.6	0.2	-3.7	1.9	-3.6
Heel T-Score	0.6	4.9	9.4	2.2	-1.2	3.1	-1.9
BMI	0.4	2.5	4.3	-2.1	-2.0	-0.9	-1.1
Height	0.7	13.4	20.9	-4.6	2.7	-4.1	2.9
Waist Hip Ratio (WHR)	0.8	3.6	6.3	-0.4	-2.5	1.2	-2.5
Systolic Blood Pressure	0.1	0.4	0.8	-0.9	-0.1	-0.6	-0.7
Smoking Status	0.6	1.5	2.1	-1.5	1.2	-1.3	0.9
Allergy or Eczema	0.3	0.9	2.5	-1.6	-0.1	-1.1	-0.0
Cardiovascular Disease	0.8	2.5	4.0	-2.0	-1.5	0.2	-1.9
Hypothyroidism (self reported)	12.9	29.6	43.3	5.7	6.6	1.1	6.4
Respiratory disease	1.3	2.8	4.4	-1.2	-2.1	1.4	-1.9
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.6	0.2	-0.8	1.6	-0.9
Lung FEV1/FVC ratio	1.2	6.0	17.5	-4.2	0.8	-2.4	0.5
Lung FVC	0.3	1.4	3.2	0.3	1.4	-0.7	1.8
Neuroticism	0.3	0.6	1.8	0.7	0.5	0.2	1.4
Chronotype (morning person)	0.4	1.0	1.8	-1.3	1.0	-0.5	1.0
Hair Pigment	0.4	10.9	23.4	4.8	2.2	3.7	1.2
Tanning	0.1	1.2	3.0	-0.5	1.3	0.1	1.7
Hand grip strength (left)	3.1	8.2	15.8	1.1	3.7	-1.4	4.0
Number of treatments/medications taken	0.2	0.4	1.0	-0.3	-0.7	0.5	-1.0
Average weekly spirits intake	1.2	1.5	3.1	1.5	0.4	1.8	0.7
Sensitivity / hurt feelings	2.4	4.2	8.8	1.5	2.3	0.6	3.0
Frequency of depressed mood in last 2 weeks	2.3	3.2	5.4	2.2	-1.4	2.3	-0.9
Hearing difficulty/problems: Yes	0.6	0.9	2.9	0.9	-0.1	1.7	-0.0
Relative age of first facial hair	0.1	0.3	0.6	0.2	-0.1	0.7	-0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.1	0.6	0.3	0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.6	-1.6	-0.6	-0.2	-0.8
Ever had hysterectomy (womb removed)	1.5	1.7	3.4	0.4	1.7	0.4	1.9
Systolic blood pressure, automated reading	0.2	0.5	0.9	-1.0	-0.5	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.2	-1.5	0.0	-0.6	-0.2
Angina	0.5	0.7	1.0	-0.7	-0.8	1.0	-0.8
Medication for hormone replacement therapy	0.5	0.5	1.1	-0.9	-0.5	-1.0	-0.2
Vitamin and mineral supplements	1.7	2.3	5.9	-0.6	-1.7	0.1	-2.4
Supplements: Zinc	4.6	5.0	9.5	1.4	2.9	0.4	3.1
Medication: Co-codamol	1.1	1.3	1.9	-0.9	-1.4	0.7	-1.4
Medication: Metformin	1.2	1.7	5.3	0.9	-0.5	2.3	-0.7
Diabetes (father)	0.2	0.2	0.8	0.1	-0.2	-0.1	-0.9
Diabetes (mother)	1.3	1.6	3.7	-0.7	-0.8	1.3	-1.9
Severe depression (siblings)	1.4	1.6	2.7	-0.5	1.2	-1.7	1.4
Pack years adult smoking proportion	0.5	0.8	1.7	-1.3	0.1	-1.2	-0.1
Impedance of leg (right)	0.2	0.9	1.5	0.8	1.2	-0.6	1.0
Leg fat-free mass (left)	0.6	3.0	8.2	-2.9	-0.7	-1.8	-0.3
Trunk fat percentage	1.4	5.8	12.2	-3.5	-1.9	-2.2	-1.5
Hand grip strength (right)	1.3	3.5	6.3	-0.1	2.5	-1.7	2.2
Townsend deprivation index at recruitment	0.3	0.5	1.1	-0.4	-1.0	0.1	-0.9
Current tobacco smoking	0.4	0.7	1.9	-0.9	0.3	-1.4	-0.2
Average weekly fortified wine intake	1.7	2.0	3.7	-0.7	-1.9	0.0	-1.9
Maternal smoking around birth	0.7	1.0	2.5	-1.1	-0.2	-1.6	0.3
Fed-up feelings	0.1	0.2	0.4	0.5	0.2	-0.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	5.8	0.3	-2.4	0.6	-1.9
Relative age voice broke	0.3	0.4	1.1	-0.8	-0.1	-0.2	-1.1
Taking other prescription medications	0.6	0.9	1.7	0.9	0.8	1.3	0.6
Age when periods started (menarche)	1.3	3.0	3.9	0.9	-2.0	1.9	-2.0
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.4	-0.3	1.1	-0.5	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.8	0.2	-1.4	0.7	-1.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.2	-0.5	0.2	1.1	-0.1
Qualifications: CSEs or equivalent	1.5	2.0	5.8	2.4	0.4	0.2	1.4
Serious illness, injury or assault to yourself	1.8	2.2	4.2	0.3	2.0	-0.5	2.0
High blood pressure	0.8	2.2	3.0	-1.7	-1.6	0.2	-1.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.6	-2.1	0.5	-1.8	0.7
Multivitamins +/- minerals	3.6	4.6	9.9	1.8	2.1	0.9	3.1
Stomach or abdominal pain in last month	0.6	0.7	2.0	-0.0	-1.4	0.2	-0.9
Supplements: Glucosamine	0.9	1.2	3.2	-0.3	1.1	-0.3	1.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	0.9	-1.1	0.4	-0.6
Medication: Atenolol	0.6	0.7	1.4	-1.2	0.2	-0.5	-1.1
Medication: Levothyroxine sodium	7.0	11.8	20.0	4.5	3.5	1.5	3.5
Sitting height	1.3	9.4	11.1	-2.6	3.0	-3.3	3.3
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	-0.0	-1.0	0.5	-0.9
High blood pressure (mother)	0.6	0.8	1.5	0.8	1.2	0.5	1.0
Body mass index (BMI)	1.2	5.1	8.1	-2.6	-2.8	-0.8	-2.1
Impedance of leg (left)	0.3	1.7	3.2	1.0	1.8	-0.5	1.5
Leg predicted mass (left)	0.6	3.2	9.1	-3.0	-0.7	-1.8	-0.3
Trunk fat mass	1.4	5.8	13.9	-3.7	-1.7	-2.3	-1.2
Waist circumference	1.6	6.0	8.5	-2.9	-2.9	-1.1	-2.4
Number of incorrect matches in round	0.9	1.4	3.2	-1.8	-0.9	-0.8	-0.9
Past tobacco smoking	0.3	0.5	0.9	0.6	-0.8	-0.5	-0.9
Alcohol usually taken with meals	1.3	2.1	3.9	0.1	1.7	-1.2	2.0
Nervous feelings	0.2	0.4	0.5	-0.6	-0.7	0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	4.3	2.0	-2.1	1.8	-1.3
Hearing difficulty/problems with background noise	1.5	2.5	6.7	1.8	0.2	2.6	0.0
Hair/balding pattern: Pattern 2	0.9	1.1	1.6	1.3	-1.0	0.5	-1.2
Had menopause	2.8	3.5	8.8	-1.3	1.2	-3.0	1.5
Had other major operations	0.7	0.9	1.4	-0.5	1.2	-1.1	0.9
Forced vital capacity (FVC)	1.4	5.6	11.4	-0.4	3.0	-1.3	3.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	0.1	-0.8	0.4	-1.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	0.3	0.5	-1.1	0.7
Qualifications: None of the above	0.2	0.4	0.5	-0.7	-0.6	0.7	-0.5
Financial difficulties in last 2 years	0.6	0.8	1.4	0.2	-1.2	0.8	-1.0
Mouth/teeth dental problems	0.5	0.7	1.6	-1.3	-0.3	-0.8	-0.7
Heart attack	0.9	1.1	1.8	-0.9	0.9	-1.3	1.1
Allergy	0.8	1.8	5.1	2.2	-0.3	1.3	-0.6
Pain all over the body in last month	0.9	0.9	1.6	0.8	1.3	-0.3	1.2
Diabetes (self-reported)	1.2	1.9	5.2	0.0	-0.9	2.3	-1.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.3	-1.8	-0.3	-1.1	-0.7
Medication: Ramipril	2.7	3.4	6.8	-1.0	-2.4	0.2	-2.6
Medication: Simvastatin	0.4	0.5	1.4	-1.2	-0.5	0.5	-0.5
Fluid intelligence score	0.7	1.4	2.1	0.0	1.3	-1.3	1.5
Illnesses of siblings	0.2	0.3	0.7	-0.6	-0.2	-0.8	-0.3
Neuroticism score	0.1	0.3	0.6	0.7	0.1	0.2	0.8
Weight	0.9	4.6	12.4	-3.5	-1.3	-2.1	-0.5
Impedance of arm (right)	0.5	2.4	4.1	1.1	2.0	-0.5	2.0
Arm fat percentage (right)	0.9	3.7	6.8	-2.6	-2.1	-1.3	-1.4
Trunk fat-free mass	0.2	1.3	3.6	-1.9	0.1	-1.0	0.7
Hip circumference	0.7	2.9	4.9	-2.2	-1.9	-1.1	-1.4
Time employed in main current job	1.3	1.5	3.0	1.0	-1.1	1.7	-0.9
Alcohol intake versus 10 years previously	0.8	1.2	1.6	1.2	0.9	0.9	1.3
Father’s age at death	0.6	0.8	2.0	-0.0	-1.1	-0.0	-1.4
Worrier / anxious feelings	0.2	0.4	1.1	0.5	0.3	1.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.5	1.9	1.0	-0.3	1.3
Falls in the last year	0.5	0.6	1.4	-0.1	1.2	-0.1	1.0
Hair/balding pattern: Pattern 3	4.0	5.9	10.6	-3.2	1.6	-2.8	1.6
Number of live births	0.3	0.4	1.0	1.0	-0.2	-0.5	0.3
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	10.3	-0.9	2.9	-1.4	3.2
Pulse rate	0.9	1.5	3.8	-2.0	-0.7	-0.8	-1.1
Happiness	4.2	5.1	11.5	-3.4	0.2	-2.9	-0.6
Noisy workplace	0.3	0.4	0.7	0.7	0.6	0.9	0.1
Qualifications: A levels/AS levels or equivalent	2.5	5.6	9.5	0.4	3.0	-1.9	3.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.0	0.3	1.0	0.9	0.9
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	0.3	0.1	0.4	0.0
Asthma	1.0	2.0	3.7	-1.9	-1.6	-0.0	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	0.9	0.0	-0.1	0.2
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.8	0.5	0.3	0.3
Depression (self-reported)	0.2	0.3	0.6	0.1	0.7	0.2	0.8
Medication: Lansoprazole	1.3	1.5	4.0	2.0	-0.2	1.3	0.4
Prospective memory result	1.0	1.3	2.3	-1.5	-1.1	-0.7	-1.1
Lung cancer (father)	2.7	3.2	7.5	0.0	-2.7	0.2	-2.3
Illnesses of mother	0.3	0.3	1.0	-0.0	0.3	-0.4	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.5	10.0	-1.2	3.1	-2.3	3.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	0.5	1.0	0.0	0.8
Impedance of arm (left)	0.3	1.3	2.2	0.7	1.5	-0.7	1.3
Arm fat mass (right)	1.1	4.5	9.1	-3.0	-2.2	-1.4	-1.4
Trunk predicted mass	0.2	1.3	3.8	-1.9	0.1	-0.9	0.7
Standing height	0.9	9.0	11.7	-2.2	3.2	-3.1	3.4
Length of working week for main job	0.4	0.5	0.9	-0.3	-0.7	-0.6	-0.9
Exposure to tobacco smoke at home	4.8	5.4	8.6	-2.9	-2.1	-0.6	-2.9
Breastfed as a baby	1.8	2.3	3.4	1.6	1.4	1.1	1.9
Tense / ‘highly strung’	0.3	0.5	1.6	0.6	0.2	1.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	0.1	-0.6	1.0	-0.9
Hair/balding pattern: Pattern 4	2.1	5.0	9.3	1.3	3.0	-0.2	3.0
Birth weight of first child	1.2	2.1	5.2	2.3	0.8	1.2	1.2
Peak expiratory flow (PEF)	5.2	12.1	25.2	-0.1	4.7	-1.3	5.0
Pulse wave reflection index	2.8	3.5	7.9	2.8	1.2	1.7	1.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	-0.1	-0.2	-0.3
Loud music exposure frequency	1.1	1.2	3.8	1.9	0.7	0.7	0.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.1	0.3	1.7	-0.4	2.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.4	2.3	0.2	0.9	1.0
Blood clot in the leg (DVT)	0.7	0.8	1.7	-0.7	1.1	0.0	1.3
Medication: Paracetamol	0.3	0.5	1.6	1.3	-0.0	0.7	0.2
Headache pain in last month	2.6	4.5	7.2	2.0	-1.9	2.7	-1.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.8	1.0	1.0	-1.4	1.0
Glaucoma (self-reported)	0.5	0.6	1.3	-0.2	1.1	-0.8	0.6
Gout (self-reported)	2.2	3.1	6.3	1.7	1.7	-0.2	2.5
Hypothyroidism/myxoedema (self-reported)	8.9	17.3	25.9	4.4	5.1	1.1	4.8
Medication: Amlodipine	1.0	1.4	2.1	-0.8	-1.5	1.1	-1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	-0.2	0.9	-0.3	0.8
Birth weight	0.8	1.7	3.6	1.0	1.9	-0.6	1.3
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.5	0.3	-1.5	0.3	-1.6
High blood pressure (siblings)	0.2	0.2	0.5	-0.7	0.3	0.5	0.2
Forced vital capacity (FVC), Best measure	1.4	5.3	9.1	-0.5	2.9	-1.8	3.0
Body fat percentage	1.4	5.4	10.6	-3.2	-2.1	-2.0	-1.6
Leg fat percentage (right)	1.0	3.7	5.3	-2.3	-2.3	-1.2	-1.7
Arm fat-free mass (right)	0.6	3.0	9.3	-3.0	-0.9	-1.3	-0.5
Exposure to tobacco smoke outside home	0.3	0.4	0.9	1.0	0.2	0.3	0.8
Comparative body size at age 10	0.2	0.6	1.6	0.6	-0.7	-1.3	-0.1
Number of full brothers	0.3	0.4	1.0	0.7	0.4	-0.0	1.0
Worry too long after embarrassment	0.7	1.2	1.4	1.2	1.1	1.0	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.5	-0.6	-0.7	-0.0	-0.7
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.6	0.1	0.3	0.6
Number of children fathered	0.1	0.2	0.3	-0.6	0.2	-0.5	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	-1.2	-0.8	-0.9	-0.6
Age at first live birth	1.4	2.4	3.6	1.6	1.9	1.2	1.5
Pulse wave peak to peak time	0.3	0.4	0.7	-0.6	-0.9	-0.2	-0.6
Health satisfaction	0.2	0.3	0.8	-0.3	-0.9	-0.1	-0.6
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.1	-0.5	-0.0	-0.3
Qualifications: College or University degree	0.2	0.8	1.6	1.3	0.6	1.0	0.2
Eye problems/disorders: None of the above	0.5	0.5	1.1	-0.4	0.7	-0.6	1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.2	0.3	0.7	0.7
Emphysema/chronic bronchitis	2.4	2.7	5.6	2.1	-0.8	2.4	-0.4
Medication for pain relief, constipation, heartburn	1.1	2.0	5.5	-1.4	0.5	-2.3	0.2
Neck or shoulder pain in last month	1.5	2.2	4.6	0.5	1.6	-1.2	2.1
Medication: Blood pressure	0.6	1.1	2.3	-1.5	-0.8	0.6	-1.1
Angina (self-reported)	0.6	0.8	1.3	-1.2	-0.8	0.6	-0.9
Migraine (self-reported)	1.8	2.2	3.6	1.3	1.9	0.7	1.8
Medication: Ibuprofen	0.2	0.2	0.6	0.8	-0.0	-0.2	0.3
Medication: Allopurinol	0.7	0.9	2.1	-0.1	1.1	-0.7	1.4
Medication: Omeprazole	0.6	0.7	0.8	0.9	0.8	0.9	0.7
Medication: Seretide 50 evohaler	0.7	0.8	2.3	-0.1	-0.8	1.5	-0.5
Mean time to correctly identify matches	0.7	1.3	2.4	-1.5	-0.8	-0.6	-1.3
Heart disease (mother)	0.5	0.5	1.3	0.5	1.1	0.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	5.9	1.6	2.2	1.2	2.4
Whole body fat mass	1.4	5.8	12.7	-3.6	-2.1	-2.1	-1.4
Leg fat mass (right)	1.4	5.4	10.6	-3.3	-2.2	-1.9	-1.6
Arm predicted mass (right)	0.5	2.7	8.3	-2.9	-0.8	-1.4	-0.3
Pulse rate, automated reading	0.3	1.1	2.3	-1.5	-0.4	0.6	-1.1
Alcohol intake frequency.	1.8	4.2	9.3	-0.6	-2.7	-0.1	-3.0
Comparative height size at age 10	1.9	10.3	15.9	-3.2	2.7	-4.0	2.8
Number of full sisters	0.6	0.7	1.6	-1.2	-0.0	0.5	-1.0
Suffer from ‘nerves’	0.4	0.7	2.4	1.6	-0.1	0.3	0.4
Overall health rating	0.7	1.4	2.1	-1.4	-1.4	0.4	-1.3
Chest pain or discomfort	0.1	0.2	0.4	-0.6	-0.6	0.1	-0.2
Had major operations	1.5	1.8	4.5	1.3	-0.5	2.1	-0.9
Age at last live birth	2.2	3.2	6.7	2.6	1.8	0.8	1.5
Family relationship satisfaction	0.1	0.2	0.4	-0.2	-0.3	-0.7	0.0
Leg pain on walking	0.3	0.4	1.3	-0.0	-0.2	1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.9	4.2	-2.1	-0.7	-1.2	-1.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.5	0.0	-1.6	1.4	-1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-1.1	-0.6	-0.5	-0.6
Medication: Aspirin	0.5	0.6	1.9	0.3	0.5	1.4	0.6
Supplements: Vitamin C	0.8	1.0	2.2	0.3	1.2	-0.3	1.5
Knee pain experienced in last month	1.0	1.6	3.5	-0.1	1.9	-0.5	1.7
Hypertension (Self-reported)	0.5	1.5	2.1	-1.4	-1.4	-0.2	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.5	5.3	9.6	1.3	3.1	0.7	3.1
Illnesses of father: Heart disease	0.9	1.3	2.7	-0.6	1.3	-0.6	1.6
Illnesses of siblings: Diabetes	1.0	1.2	3.4	1.8	0.1	1.0	0.5
Smoking status: Previous	0.3	0.4	0.8	-0.4	0.6	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.2	-0.2	2.3	-2.1	1.9
Whole body fat-free mass	0.4	2.0	6.1	-2.5	-0.2	-1.4	0.3
Leg fat-free mass (right)	0.4	2.4	6.9	-2.6	-0.3	-1.6	0.2
Arm fat percentage (left)	1.2	4.6	7.6	-2.8	-2.4	-1.3	-1.8
Average weekly red wine intake	0.1	0.2	0.7	-0.8	-0.3	0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.5	0.8	0.3	0.9
Mood swings	0.2	0.3	0.8	0.4	-0.9	0.2	-0.3
Loneliness, isolation	0.5	0.7	2.0	-0.2	-0.9	0.1	-1.4
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.5	0.2	-0.4	0.0
Ever had bowel cancer screening	2.6	3.1	4.9	2.2	1.7	0.4	2.1
Diabetes diagnosed by doctor	1.1	1.8	5.8	0.2	-0.7	2.4	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.1	-0.1	1.6	-1.5	2.0
Friendships satisfaction	1.0	1.2	2.8	-1.4	0.3	-1.7	0.2
Qualifications: nursing, teaching	0.3	0.5	1.2	-0.0	1.1	-0.2	0.7
Commuting to job workplace: Walk	4.2	4.6	6.7	2.6	1.9	1.2	2.5
Eye problems/disorders: Cataract	0.7	0.8	1.3	1.2	0.7	1.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	0.5	0.7	0.3	0.6
Medication for cholesterol	1.6	2.4	3.5	1.9	1.5	1.3	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.4	0.1	-1.2	0.6	-0.7
Back pain experienced in last month	0.7	1.0	2.0	0.4	-1.2	1.4	-0.5
Mineral and other dietary supplements	1.6	2.1	5.1	-0.5	-1.7	-0.0	-2.3
Breast cancer (self-reported)	1.6	1.9	3.0	1.7	1.5	1.2	0.9
Asthma (self-reported)	1.4	2.7	4.8	-2.2	-1.9	-0.1	-1.6
Osteoporosis (self-reported)	0.2	0.3	0.9	-0.3	-0.1	-0.5	-0.9
Osteoarthritis (self-reported)	1.4	1.8	3.5	-0.6	1.9	-0.9	1.6
Medication: Aspirin	0.3	0.3	1.4	-0.0	0.1	1.2	0.1
Medication: Gliclazide	1.6	1.8	2.6	-0.1	-1.6	1.5	-1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.5	0.7	0.1	1.1
Smoking status: Current	0.7	1.1	2.5	-1.3	0.1	-1.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	0.0	1.1	-0.7	1.2
Whole body water mass	0.3	1.9	5.8	-2.4	-0.3	-1.2	0.3
Leg predicted mass (right)	0.4	2.4	6.8	-2.6	-0.3	-1.6	0.2
Arm fat mass (left)	1.2	4.9	9.6	-3.1	-2.3	-1.6	-1.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	0.6	0.7	1.1	0.4
Average weekly champagne plus white wine intake	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.2
Miserableness	0.6	1.0	2.2	-0.3	1.2	-0.7	1.5
Guilty feelings	1.1	1.7	3.4	0.0	1.8	-0.6	1.8
Wears glasses or contact lenses	0.1	0.1	0.1	-0.2	-0.4	-0.2	-0.4
Ever taken oral contraceptive pill	2.0	2.2	5.1	1.8	-0.5	2.2	-0.5
Hearing aid user	1.4	1.6	2.5	0.6	-1.5	1.1	-1.6
Mother’s age at death	0.9	1.2	3.6	1.9	0.8	0.2	0.6
Financial situation satisfaction	0.9	1.2	3.3	-1.8	-0.3	-1.1	-0.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	1.1	0.4	1.0	0.2
Commuting to job workplace: Public transport	0.9	1.0	2.0	0.3	1.2	-0.8	1.4
Eye problems/disorders: Glaucoma	0.3	0.3	1.1	-0.2	-0.0	-1.0	-0.3
Medication: Blood pressure	2.2	4.1	6.3	-2.5	-1.7	-1.7	-2.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.8	-0.0	-0.5	-0.0
Supplements: Fish oil (including cod liver oil)	2.1	2.8	5.6	0.5	2.3	-0.0	2.4
High cholesterol (Self-reported)	0.5	0.8	2.1	-0.8	1.4	0.2	0.8
Medication: Bendroflumethiazide	0.7	1.1	2.5	-0.3	-1.4	-0.3	-1.6
Medication: Paracetamol	0.4	0.6	1.2	1.1	0.6	0.4	0.8
Medication: Lisinopril	0.4	0.5	1.2	0.2	-1.1	0.7	-0.5
Medication: Atorvastatin	0.3	0.4	0.7	-0.8	0.3	-0.8	0.2
Illnesses of father: High blood pressure	0.2	0.2	0.3	0.4	-0.5	0.5	-0.4
Alcohol drinker status: Never	1.8	2.2	3.5	-1.3	-1.9	-0.9	-1.6
Ever smoked	0.3	0.5	1.0	-0.1	0.9	0.4	1.0
Basal metabolic rate	0.5	2.5	7.5	-2.7	-0.5	-1.5	0.1
Leg fat percentage (left)	0.9	3.1	4.8	-2.1	-2.2	-0.9	-1.6
Arm fat-free mass (left)	0.4	2.0	6.4	-2.5	-0.5	-1.2	0.0
Number of operations (self-reported)	0.7	1.1	2.8	0.7	-0.8	1.7	-0.6
Average weekly beer plus cider intake	0.4	0.6	1.0	0.9	-1.0	0.1	-0.6
Irritability	0.2	0.3	0.8	0.9	-0.5	0.5	0.3
Risk taking	0.7	1.1	2.0	0.6	-1.4	0.4	-1.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.1	-0.7	-0.1	-0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.4	0.5	0.6	-0.2	0.7
Age started oral contraceptive pill	0.0	0.1	0.2	0.2	-0.0	-0.2	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.1	-0.5	0.9	-0.2
Ever depressed for a whole week	0.4	0.5	1.1	-0.1	1.1	-0.5	0.6
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.1	-0.5	0.9	-0.6
Commuting to job workplace: Cycle	2.2	2.6	5.5	0.2	2.2	-0.4	2.3
Myopia	3.6	5.2	11.5	3.0	0.0	3.4	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.0	1.4	1.4	-0.3	1.4
Cholesterol lowering medication	0.2	0.2	0.7	-0.8	-0.1	-0.5	0.0
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	3.1	1.8	1.2	1.3	1.4
Pain experienced in last month	0.3	0.6	1.1	-1.0	0.0	-1.1	-0.4
Supplements: Calcium	1.9	2.1	3.9	0.1	-2.0	1.4	-1.6
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	-0.2	0.9	-0.3	0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.2	-0.9	0.6	-1.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.1	-0.9	1.0	0.0	1.1
Heart disease (siblings)	1.1	1.4	3.8	-1.9	-0.4	-1.1	-0.7
Alcohol drinker status: Previous	0.9	1.0	1.8	0.3	-0.6	1.4	-1.3
Pack years of smoking	0.3	0.5	0.9	-0.9	0.4	-0.9	0.2
Impedance of whole body	0.4	1.9	3.5	0.7	1.9	-1.0	1.6
Leg fat mass (left)	1.3	5.0	10.0	-3.2	-2.2	-1.7	-1.6
Arm predicted mass (left)	0.5	2.4	7.8	-2.8	-0.7	-1.2	-0.1