Hub : Genes

TMOD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0540	0.0240	0.0028	0.000	NA	-0.003	NA	0.003	3.3e-01	NA	6.5e-01	NA	1.8e-01
2	GTEx	Artery Coronary	0.1760	0.0740	0.0038	0.010	NA	0.108	NA	0.072	1.5e-01	NA	1.8e-04	NA	2.0e-03
3	GTEx	Brain Cerebellar Hemisphere	0.3400	0.0970	0.0016	0.203	NA	0.076	NA	0.215	6.2e-06	NA	5.5e-03	NA	3.1e-06
4	GTEx	Esophagus Mucosa	0.1220	0.0480	0.0023	0.044	NA	0.048	NA	0.030	6.6e-04	NA	3.7e-04	NA	4.2e-03
5	METSIM	Adipose	0.0359	0.0161	0.0025	0.038	0.019	0.029	0.022	0.029	2.2e-06	0.00057	2.7e-05	0.00023	3.0e-05
6	TCGA	Breast Invasive Carcinoma	0.0199	0.0117	0.0097	0.009	0.008	0.010	NA	0.006	3.8e-03	0.00620	2.4e-03	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.8	1.7	-1.1	0.9	-1.3	-0.6	-0.9	-0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.1	0.7	-0.3	-0.2	0.5	-0.5
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	-1.2	1.5	0.5	0.2	1.3	0.3
Depression (Nagel 2018)	0.6	0.8	2.0	-0.2	1.4	-0.2	-1.3	0.2	-1.0
Intelligence (Savage-Jansen 2018)	1.2	3.6	11.2	0.7	-1.7	0.8	3.3	1.9	1.7
Neuroticism (Nagel 2018)	1.0	2.4	3.9	-1.1	1.9	1.9	-1.2	2.0	-1.0
Schizophrenia (2018)	0.3	0.6	1.8	0.9	0.2	0.7	0.2	1.4	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	1.5	-0.1	0.2	0.4	0.4	1.2	0.3
Worry (Nagel 2018)	0.5	1.0	2.6	-1.1	0.6	1.3	-1.6	0.6	-0.3
Alzheimer’s Disease (in mother)	0.6	0.6	2.2	1.5	-0.1	1.0	0.7	0.4	-0.1
Alzheimer’s Disease (in father)	0.8	0.8	3.2	-1.8	0.5	-0.1	0.7	-0.7	0.7
Alzheimer’s Disease (including proxy)	0.2	0.4	1.1	-0.1	0.4	0.6	1.1	0.1	0.7
Crohns Disease (2017)	0.4	0.8	1.5	-0.4	1.1	0.2	0.5	1.2	1.2
Irritable Bowel Disease (IBD)	0.4	0.9	3.6	-0.3	1.9	-0.2	-0.5	1.1	0.4
Ulcerative Colitis (UC)	0.6	1.2	4.0	-0.5	2.0	-0.6	-1.5	0.3	-0.3
Major Depression (MDD)	0.5	0.7	2.1	-0.4	-0.5	-0.9	0.8	0.3	1.5
Reaction Time	0.6	1.1	3.6	0.2	1.7	-0.2	-1.9	0.3	-0.6
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.7	0.3	-0.8	1.1	1.9	1.5	1.6
Breast Cancer	0.2	0.5	1.5	0.8	0.4	-1.2	0.2	-0.5	-0.3
Ovarian Cancer	0.2	0.2	0.9	-1.0	-0.3	-0.3	0.2	-0.6	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.8	1.1	2.4	-0.3	0.7	0.8	-0.9	1.5	-1.5
Bipolar Disorder (2011)	2.4	2.3	5.1	-0.2	0.4	-0.8	-2.2	-2.1	-1.8
Body Mass Index (BMI) (2010)	0.7	1.0	2.7	-0.7	0.8	-1.6	-1.2	-0.2	-0.7
Coronary Artery Disease (CAD)	1.3	1.5	4.1	0.8	0.0	-0.4	1.8	1.1	2.0
Crohns Disease (2012)	0.4	0.7	1.5	-1.2	0.8	0.3	0.7	0.6	0.9
Mean Putamen Volume	0.5	0.6	2.1	-1.4	0.6	0.8	0.5	0.2	0.0
Fasting Glucose	1.8	2.2	8.6	2.9	-0.6	0.6	0.0	2.0	0.1
HbA1C	2.3	2.5	5.1	-1.5	0.8	1.2	-2.2	-0.9	-2.2
HDL Cholesterol	0.5	0.9	3.5	-0.1	1.1	-0.7	-1.9	0.4	-0.0
LDL Cholesterol	0.2	0.3	0.8	0.7	-0.9	0.6	-0.2	-0.1	-0.3
Lupus	0.6	1.0	3.2	-0.8	1.1	-0.1	0.7	1.8	0.6
Neuroticism (2016)	1.3	1.9	4.9	-1.0	2.2	1.4	-0.1	1.4	-1.1
Primary Biliary Cirrhosis	1.8	2.6	7.3	-0.2	2.7	0.9	-1.8	0.9	-1.9
Rheumatoid Arthritis	0.4	0.6	1.9	-0.3	-0.8	-1.4	-0.4	-0.4	0.7
Schizophrenia (2014)	0.0	0.1	0.5	0.0	0.0	-0.0	-0.0	0.3	-0.7
Triglycerides	1.4	2.4	9.5	-0.2	-1.6	0.6	3.1	-1.2	0.7
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.1	-1.7	1.8	-0.5	-0.2	-1.4	-1.3
Ulcerative Colitis	0.2	0.3	1.1	0.2	1.0	-0.6	0.2	0.1	-0.3
Blood Eosinophil Count	0.1	0.8	1.9	0.9	0.8	0.6	-0.8	0.5	1.4
Blood Platelet Count	1.7	19.7	34.8	-5.5	5.1	-0.2	-5.9	-2.2	-4.6
Blood Red Count	0.2	2.2	5.0	0.3	-2.0	1.6	2.2	0.9	0.9
Blood White Count	0.4	3.1	8.0	-0.4	-2.2	-2.4	-0.3	-2.8	-0.0
Heel T-Score	0.3	2.6	7.3	-0.2	-1.9	-0.9	-0.9	-2.7	-1.8
BMI	0.1	0.9	3.0	-0.1	0.1	-0.9	1.7	0.8	0.8
Height	0.7	14.3	35.6	5.1	2.7	3.1	-2.4	6.0	1.0
Waist Hip Ratio (WHR)	0.3	1.5	3.4	-1.8	-0.4	-0.6	-1.2	-0.6	1.8
Systolic Blood Pressure	0.2	1.2	2.9	1.1	-1.1	-0.5	-1.7	-1.1	-0.4
Smoking Status	0.2	0.5	1.1	-0.7	1.1	-0.6	-0.6	-0.0	-0.8
Allergy or Eczema	0.5	1.3	5.0	2.2	-0.5	1.2	0.7	0.1	-0.6
Cardiovascular Disease	0.1	0.5	1.3	1.1	0.1	-0.8	-0.5	-0.5	0.6
Hypothyroidism (self reported)	8.9	20.5	49.4	-0.5	-7.0	-1.1	6.3	-5.4	-1.8
Respiratory disease	0.6	1.3	4.0	-0.0	-0.8	-2.0	-1.7	-0.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.5	-0.5	0.8	-1.2	-0.1	0.1
Lung FEV1/FVC ratio	1.1	5.5	18.0	4.2	1.5	1.5	-0.2	3.2	0.5
Lung FVC	0.3	1.7	6.4	0.9	-1.2	0.7	0.3	-1.1	-2.5
Neuroticism	0.6	1.4	3.2	0.1	1.8	1.0	-0.9	1.8	0.5
Chronotype (morning person)	1.3	3.1	7.3	0.7	2.0	-0.8	-2.7	0.7	-2.3
Hair Pigment	0.3	9.1	21.6	-0.1	-3.8	-4.7	3.4	-2.6	0.5
Tanning	0.1	0.7	1.8	-1.3	-0.3	-0.8	-0.4	-0.3	1.3
Hand grip strength (left)	0.7	1.7	3.9	-2.0	1.1	-1.2	-1.8	-0.7	-0.0
Number of treatments/medications taken	0.9	1.7	4.7	2.2	-0.8	-0.6	1.3	0.4	1.5
Average weekly spirits intake	1.1	1.3	2.8	0.5	1.3	1.7	-1.2	1.4	-0.3
Sensitivity / hurt feelings	0.9	1.5	3.6	-1.1	1.9	1.0	-1.0	0.9	-1.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.7	-0.2	1.6	0.9	-0.4	0.8	-0.2
Hearing difficulty/problems: Yes	1.7	2.6	9.3	3.0	-0.5	0.2	0.9	2.1	-0.6
Relative age of first facial hair	0.2	0.3	1.4	0.4	1.2	-0.3	-0.5	0.2	0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.1	0.8	-0.5	-0.7	0.5	1.1	2.0
Ever used hormone-replacement therapy (HRT)	1.0	1.2	4.1	2.0	-0.5	0.2	-1.7	-0.3	-0.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.5	-0.6	0.7	0.5	0.2	-0.7	0.3
Systolic blood pressure, automated reading	0.2	0.6	1.3	1.1	-0.9	-1.0	0.4	-0.8	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.5	0.6	0.8	0.4	0.6	0.2
Angina	0.3	0.4	2.0	-0.1	-0.2	0.1	-1.4	-0.1	0.3
Medication for hormone replacement therapy	0.6	0.7	3.1	0.3	-0.1	-1.8	-0.6	0.1	0.6
Vitamin and mineral supplements	2.4	3.2	6.4	-2.5	-1.9	-1.9	1.6	-1.6	0.6
Supplements: Zinc	2.1	2.3	7.3	0.7	-1.9	-2.7	0.1	-0.4	1.5
Medication: Co-codamol	0.5	0.5	1.6	1.3	0.4	-0.7	0.4	0.5	0.8
Medication: Metformin	0.6	0.8	2.6	0.8	-1.0	1.6	0.0	0.8	0.1
Diabetes (father)	0.6	0.7	2.1	0.0	-1.4	-0.7	0.2	-1.1	0.5
Diabetes (mother)	0.5	0.6	2.6	-0.6	-0.7	0.0	-0.5	-0.1	1.6
Severe depression (siblings)	0.3	0.3	0.6	0.1	-0.8	0.4	0.6	0.1	0.8
Pack years adult smoking proportion	1.2	1.9	5.2	-0.1	-0.9	-2.3	0.4	-0.7	2.1
Impedance of leg (right)	0.5	2.4	6.4	-0.8	-1.1	-1.3	-1.4	-2.5	-1.5
Leg fat-free mass (left)	0.3	1.7	4.7	0.9	0.1	0.2	0.9	2.2	1.9
Trunk fat percentage	0.3	1.0	2.8	1.1	-0.9	-0.2	1.7	0.5	1.1
Hand grip strength (right)	0.6	1.7	4.6	-1.4	0.7	-0.4	-2.2	-0.8	-1.5
Townsend deprivation index at recruitment	0.5	0.7	1.4	-1.0	-0.3	-1.1	-0.0	-0.5	1.2
Current tobacco smoking	0.3	0.5	2.5	-1.6	-0.0	0.1	0.3	-0.3	0.8
Average weekly fortified wine intake	0.3	0.4	1.3	0.4	0.4	-1.1	-0.2	-0.3	0.6
Maternal smoking around birth	0.8	1.1	1.7	1.1	-0.9	0.5	1.1	1.2	1.3
Fed-up feelings	0.7	1.2	2.1	-1.2	1.4	-0.7	1.4	0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	0.7	1.3	0.4	-0.1	0.4	-0.4
Relative age voice broke	1.1	1.7	4.7	-0.6	2.2	-0.5	-1.8	-0.5	-1.1
Taking other prescription medications	0.7	1.1	4.1	2.0	-1.3	0.2	0.9	0.4	0.1
Age when periods started (menarche)	0.3	0.8	2.6	1.1	-0.3	-0.4	1.6	-0.9	-0.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.8	0.5	0.9	0.3	-0.1	1.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	5.8	-0.5	1.1	-2.3	-2.4	-1.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.7	-1.2	1.3	0.3	-0.6	-0.1	-1.0
Qualifications: CSEs or equivalent	1.8	2.4	4.0	2.0	-1.1	-0.9	1.8	1.8	1.4
Serious illness, injury or assault to yourself	0.7	0.8	2.1	-1.0	1.0	-0.0	0.5	0.9	1.5
High blood pressure	0.6	1.6	5.9	2.4	-1.0	1.3	0.5	0.9	0.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.7	1.6	-0.7	0.8	1.1	-0.1	-0.1
Multivitamins +/- minerals	1.5	1.9	4.1	2.0	1.0	1.6	-0.5	1.9	0.1
Stomach or abdominal pain in last month	0.5	0.6	1.4	0.3	1.1	0.4	-0.4	0.8	1.2
Supplements: Glucosamine	0.7	0.9	3.3	1.8	-0.4	0.5	1.1	0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.5	0.3	-1.3	0.1	1.0	-0.4	1.6
Medication: Atenolol	0.7	0.8	1.9	1.4	-1.0	0.1	-0.6	-0.8	1.0
Medication: Levothyroxine sodium	6.7	11.4	26.2	-0.4	-5.1	-0.9	4.8	-4.1	-1.3
Sitting height	0.2	1.7	3.8	0.8	0.1	-0.0	-1.5	2.0	1.8
Chronic bronchitis/emphysema (father)	0.7	0.8	1.8	0.9	-0.6	-0.1	0.9	0.9	1.4
High blood pressure (mother)	0.8	1.1	2.3	-1.5	1.5	-0.2	0.6	0.8	1.0
Body mass index (BMI)	0.5	2.0	5.3	1.1	-1.4	-0.7	2.3	0.3	1.8
Impedance of leg (left)	0.5	2.2	4.5	-0.8	-0.5	-1.5	-1.7	-2.1	-1.7
Leg predicted mass (left)	0.3	1.6	4.4	0.9	0.1	0.1	0.8	2.1	1.9
Trunk fat mass	0.4	1.6	2.9	1.5	-1.1	-0.3	1.6	0.9	1.7
Waist circumference	0.6	2.1	4.7	1.1	-2.2	-0.7	1.7	-0.3	1.9
Number of incorrect matches in round	0.7	1.2	3.1	0.9	1.2	-0.6	-1.8	-1.1	-0.5
Past tobacco smoking	0.6	1.1	3.9	1.0	-2.0	-0.2	0.9	-0.6	0.9
Alcohol usually taken with meals	3.9	6.3	13.6	1.4	3.2	1.7	-2.7	1.4	-3.7
Nervous feelings	0.6	1.0	3.4	-0.0	0.2	1.8	-0.5	1.0	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.8	-0.0	1.0	0.3	-1.9	0.1	-0.5
Hearing difficulty/problems with background noise	2.1	3.3	10.0	2.6	1.5	0.4	-0.6	3.2	0.1
Hair/balding pattern: Pattern 2	0.7	0.8	3.2	-1.2	-0.2	0.2	-0.3	0.4	1.8
Had menopause	2.5	3.1	8.9	3.0	1.5	0.6	0.1	2.6	0.2
Had other major operations	2.3	2.8	10.7	3.3	-2.0	-0.1	1.5	-0.0	-0.1
Forced vital capacity (FVC)	0.1	0.4	1.4	-0.1	0.1	0.1	-1.2	0.6	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.8	0.4	0.9	-1.1	-2.0	-0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.0	1.4	0.1	-0.5	0.0	1.1	-1.1
Qualifications: None of the above	0.5	1.1	3.5	1.9	0.6	-0.3	0.4	1.1	1.0
Financial difficulties in last 2 years	1.0	1.4	3.1	-1.5	1.8	0.3	-1.6	0.7	-0.1
Mouth/teeth dental problems	1.5	2.3	4.5	-0.9	0.7	-0.9	-2.0	-2.1	-1.7
Heart attack	0.7	1.0	2.9	0.6	-0.8	-1.1	-0.8	-0.2	1.7
Allergy	0.4	0.9	3.5	-1.9	1.1	0.3	-0.6	0.2	0.1
Pain all over the body in last month	0.9	1.0	2.6	1.6	-1.4	-0.5	0.4	0.8	-0.5
Diabetes (self-reported)	0.3	0.5	1.9	0.1	-1.4	1.1	-0.1	-0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.5	1.9	-0.7	1.0	0.3	0.3	-1.1
Medication: Ramipril	1.7	2.2	4.4	0.8	-1.4	-1.4	2.1	-1.7	1.1
Medication: Simvastatin	0.1	0.2	0.7	0.3	0.8	-0.1	-0.2	-0.6	-0.4
Fluid intelligence score	1.0	2.1	3.2	-0.3	-1.1	1.3	1.8	1.8	1.7
Illnesses of siblings	0.5	0.7	1.7	-0.5	-1.3	0.0	-0.7	-0.9	-1.1
Neuroticism score	0.4	0.8	2.1	-0.3	1.2	1.5	-0.3	1.0	0.5
Weight	0.4	1.9	3.4	1.8	-0.8	-0.1	1.3	1.6	1.8
Impedance of arm (right)	0.4	1.7	3.4	-1.2	1.8	1.0	-1.0	0.3	-1.9
Arm fat percentage (right)	0.4	1.5	4.5	1.2	-1.1	-0.3	2.1	0.5	1.3
Trunk fat-free mass	0.3	1.6	4.8	1.5	-0.3	0.6	0.3	2.2	1.5
Hip circumference	0.6	2.5	4.5	2.1	-1.9	-0.6	2.1	0.4	1.5
Time employed in main current job	0.6	0.7	2.6	1.1	0.2	-1.6	-0.1	-0.3	0.5
Alcohol intake versus 10 years previously	1.1	1.6	5.3	0.1	-1.3	-0.1	2.3	1.0	1.4
Father’s age at death	0.7	1.0	3.0	1.5	0.0	1.7	-0.7	0.3	0.1
Worrier / anxious feelings	0.6	1.2	4.2	-0.6	0.8	1.1	-2.1	0.7	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	-0.9	0.0	-0.6	0.6	-0.9	0.4
Falls in the last year	1.7	2.3	6.4	0.4	0.5	2.5	-1.1	1.4	-2.0
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	-0.2	0.7	1.1	-0.8	-0.7	-1.3
Number of live births	0.8	1.2	3.3	1.8	-0.7	-0.6	-1.1	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.6	1.1	0.5	0.2	-1.3	1.2	-0.7
Pulse rate	0.3	0.5	1.2	-0.2	0.8	0.4	1.1	0.6	0.8
Happiness	0.6	0.7	1.7	-0.7	1.3	0.3	-1.3	-0.6	0.3
Noisy workplace	1.6	1.9	4.7	-0.6	-2.1	-0.9	1.1	-2.2	0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.0	-1.3	0.3	2.0	-1.7	-0.3	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	6.3	1.9	-0.1	0.7	-0.2	2.5	-0.8
Mouth/teeth dental problems: Dentures	0.4	0.7	2.6	0.6	0.1	0.7	0.7	1.6	-0.5
Asthma	0.3	0.6	3.0	0.0	0.0	-1.7	-0.5	-0.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	5.6	-0.8	-1.2	-0.1	1.3	0.4	2.4
Medication: Cholesterol lowering	0.2	0.3	0.8	0.9	0.4	0.0	0.2	0.2	0.7
Depression (self-reported)	0.3	0.4	1.2	0.3	-0.3	-0.5	-0.2	-0.7	1.1
Medication: Lansoprazole	2.6	3.0	7.7	2.8	0.3	-0.5	1.3	2.6	1.3
Prospective memory result	0.5	0.7	1.6	1.3	0.0	-1.3	0.1	-0.5	-0.7
Lung cancer (father)	1.0	1.1	2.2	1.5	-1.3	0.9	1.0	0.7	0.8
Illnesses of mother	0.3	0.4	1.3	0.4	-0.5	-0.5	-0.0	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.5	0.5	-0.1	0.8	-1.0	0.9	-1.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.9	-0.1	0.2	-1.0	0.2	-0.7	-0.3
Impedance of arm (left)	0.3	1.5	3.2	-0.6	1.5	0.8	-1.5	-0.1	-1.8
Arm fat mass (right)	0.5	2.0	4.9	1.2	-0.8	-0.0	2.2	1.1	1.9
Trunk predicted mass	0.3	1.7	5.1	1.6	-0.3	0.6	0.3	2.2	1.5
Standing height	0.3	3.0	8.6	1.7	1.1	1.4	-1.8	2.9	0.7
Length of working week for main job	0.3	0.3	0.9	0.4	0.2	-1.0	-0.1	-0.0	0.8
Exposure to tobacco smoke at home	0.5	0.6	1.4	0.6	1.2	0.6	-0.3	1.0	-0.5
Breastfed as a baby	0.2	0.3	0.8	0.2	0.0	0.3	-0.9	0.2	-0.8
Tense / ‘highly strung’	0.5	0.8	2.4	-0.1	0.2	-0.8	-1.3	0.4	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.5	-0.6	0.0	-0.0	-0.3	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	2.7	1.6	-0.5	-0.8	-0.3	1.0	-0.5
Birth weight of first child	0.6	1.0	3.7	-0.9	-1.9	-0.1	1.2	0.2	0.1
Peak expiratory flow (PEF)	0.3	0.6	1.6	0.8	0.3	-0.5	-1.3	0.5	-0.8
Pulse wave reflection index	0.3	0.3	1.1	-1.0	0.0	-0.3	-0.2	-0.4	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	0.9	0.1	-0.1	0.5	0.8	0.1
Loud music exposure frequency	0.6	0.6	1.1	-0.8	0.9	0.3	0.8	-1.1	-0.8
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	6.4	-1.5	-0.8	1.8	-0.1	-1.2	-2.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.4	-0.4	0.9	-0.1	1.5	1.7	2.1
Blood clot in the leg (DVT)	1.8	2.3	5.8	1.3	0.2	-1.2	-2.0	-1.0	-2.4
Medication: Paracetamol	0.4	0.7	2.6	0.1	-0.8	1.6	0.6	0.5	-0.6
Headache pain in last month	0.4	0.7	1.5	-0.1	-1.0	0.8	-0.1	1.0	1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	5.4	-2.3	0.2	-0.1	0.2	-0.6	-0.9
Glaucoma (self-reported)	0.9	1.1	3.0	-0.3	-0.5	-0.2	1.7	-1.4	1.1
Gout (self-reported)	0.5	0.7	1.8	-0.9	1.0	-0.4	1.3	-0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	8.3	16.2	36.7	-1.0	-6.1	-1.0	5.2	-5.3	-1.9
Medication: Amlodipine	0.7	1.0	2.4	1.2	-0.8	-1.0	0.6	0.1	1.6
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.9	-1.7	-1.2	-0.8	-0.2	-1.2	0.1
Birth weight	0.5	1.2	2.8	-0.2	-1.7	-1.4	1.3	-0.3	0.8
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	0.1	-0.5	0.1	-0.1	-0.7	0.4
High blood pressure (siblings)	1.1	1.6	4.5	0.1	1.6	-0.3	1.0	1.1	2.1
Forced vital capacity (FVC), Best measure	0.2	0.7	2.0	-0.6	-0.5	0.2	-1.2	-0.1	-1.4
Body fat percentage	0.4	1.6	3.6	1.4	-1.4	-0.8	1.9	0.0	1.2
Leg fat percentage (right)	1.2	4.4	11.6	1.7	-3.4	-1.3	2.4	-1.4	1.5
Arm fat-free mass (right)	0.3	1.4	3.2	1.4	-0.7	-0.6	0.3	1.5	1.8
Exposure to tobacco smoke outside home	1.1	1.4	6.9	-1.0	-0.3	-0.2	2.6	0.1	0.6
Comparative body size at age 10	0.4	1.1	4.2	-1.4	0.4	0.4	2.0	0.6	0.0
Number of full brothers	1.3	1.6	6.7	0.2	-0.2	0.2	2.6	0.7	1.6
Worry too long after embarrassment	0.9	1.6	3.5	0.3	0.9	1.9	-1.2	1.4	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.3	-0.5	-0.4	0.1	-0.4	1.0
Wheeze or whistling in the chest in last year	0.3	0.6	2.1	-1.0	1.4	-0.0	0.0	0.6	0.2
Number of children fathered	1.3	1.5	5.0	-0.2	-0.4	-2.2	-1.5	-1.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.1	8.8	0.5	-3.0	-0.8	-0.6	-2.5	-1.5
Age at first live birth	1.4	2.4	4.1	-1.1	1.6	1.4	-2.0	1.0	-1.9
Pulse wave peak to peak time	0.4	0.5	1.5	0.3	-0.1	1.2	-0.2	1.1	0.4
Health satisfaction	0.2	0.3	0.7	-0.6	-0.9	0.3	0.4	-0.7	0.1
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.0	-0.3	-0.1	0.8	0.2	0.6
Qualifications: College or University degree	1.0	3.1	10.1	-0.8	0.6	1.7	-3.2	-0.6	-1.9
Eye problems/disorders: None of the above	0.5	0.6	2.0	-0.9	0.6	-0.1	-1.4	-0.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.6	-0.0	-0.2	-0.5	-0.2	-0.0
Emphysema/chronic bronchitis	1.2	1.4	3.9	-0.7	0.2	-1.7	0.3	0.8	2.0
Medication for pain relief, constipation, heartburn	0.9	1.5	3.5	-1.8	1.4	0.3	-0.1	-0.2	-1.9
Neck or shoulder pain in last month	1.6	2.3	7.7	0.8	-1.2	-0.0	2.8	1.2	1.6
Medication: Blood pressure	0.9	1.5	6.0	2.4	-1.0	0.0	-0.0	0.7	1.3
Angina (self-reported)	0.4	0.5	2.4	-0.1	-0.4	-0.2	-1.6	-0.2	0.7
Migraine (self-reported)	0.6	0.7	1.8	0.9	-1.4	0.7	-0.4	0.6	-0.8
Medication: Ibuprofen	0.9	1.1	3.6	-1.3	-0.0	0.1	0.4	1.2	1.9
Medication: Allopurinol	0.1	0.2	0.5	-0.3	0.7	0.3	0.4	-0.0	-0.5
Medication: Omeprazole	1.4	1.7	4.3	0.2	1.1	-1.5	-2.1	1.3	0.5
Medication: Seretide 50 evohaler	1.3	1.5	3.0	-1.6	-1.7	-0.2	-0.7	-1.0	1.4
Mean time to correctly identify matches	0.9	1.7	4.6	2.1	0.7	1.0	-1.8	0.3	-1.0
Heart disease (mother)	0.8	1.0	4.3	-2.1	0.0	-1.1	-0.2	-0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	0.9	-1.1	-0.4	-0.3	-0.7	-0.9
Whole body fat mass	0.4	1.6	3.0	1.5	-1.1	-0.6	1.6	0.8	1.7
Leg fat mass (right)	0.8	3.0	5.4	1.7	-2.3	-1.2	2.3	-0.3	1.8
Arm predicted mass (right)	0.3	1.5	3.2	1.6	-0.6	-0.3	0.4	1.8	1.6
Pulse rate, automated reading	0.2	0.7	2.5	0.3	-0.1	0.7	1.1	1.6	0.1
Alcohol intake frequency.	0.3	0.6	3.0	-0.1	0.1	-1.7	0.2	-0.2	0.9
Comparative height size at age 10	0.9	4.7	12.3	2.3	2.2	2.4	-0.6	3.5	0.3
Number of full sisters	0.3	0.4	1.3	-0.4	-0.3	-0.2	-1.0	-1.1	-0.1
Suffer from ‘nerves’	0.8	1.2	4.9	0.6	0.2	2.2	0.1	1.4	0.3
Overall health rating	0.1	0.3	0.9	1.0	0.0	-0.5	-0.0	-0.6	0.6
Chest pain or discomfort	0.3	0.4	1.1	1.1	-0.7	0.3	-0.1	0.8	0.3
Had major operations	2.5	3.0	7.3	-1.6	-2.7	-0.2	1.6	-1.8	1.4
Age at last live birth	1.7	2.5	8.3	-1.2	1.1	0.9	-2.9	0.4	-1.7
Family relationship satisfaction	0.4	0.5	1.2	-0.8	-0.1	-0.7	1.1	-0.7	-0.1
Leg pain on walking	0.2	0.3	0.9	1.0	-0.2	0.0	-0.6	0.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	-0.7	0.7	-1.0	0.1	-0.3	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	-0.3	-0.7	-0.4	0.3	-1.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	-0.1	-1.3	-0.3	-0.2	-1.2	0.2
Medication: Aspirin	1.7	2.3	5.2	2.3	-2.0	-0.7	0.5	-0.5	1.8
Supplements: Vitamin C	0.8	1.0	3.5	1.9	0.8	0.7	-0.2	1.1	0.3
Knee pain experienced in last month	1.7	2.6	5.3	0.6	-0.7	1.4	2.3	1.8	2.0
Hypertension (Self-reported)	0.4	1.2	2.8	1.7	-0.7	1.1	1.0	0.9	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.4	-0.3	-0.0	-1.9	-1.4	0.0	0.2
Illnesses of father: Heart disease	0.9	1.3	3.6	0.7	-1.9	-1.0	0.4	-1.0	1.2
Illnesses of siblings: Diabetes	0.5	0.6	1.5	-1.0	-0.6	1.2	-0.7	-0.3	-0.1
Smoking status: Previous	0.3	0.4	1.1	0.4	0.8	0.2	-0.6	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.8	-1.0	0.8	-1.3	-0.2	0.6	0.0
Whole body fat-free mass	0.3	1.8	5.4	1.4	-0.1	0.4	0.5	2.3	1.7
Leg fat-free mass (right)	0.4	2.0	7.4	0.9	0.5	0.3	0.6	2.7	1.8
Arm fat percentage (left)	0.5	1.9	4.5	1.3	-1.5	-0.6	2.1	0.2	1.5
Average weekly red wine intake	0.2	0.3	0.8	0.8	0.2	0.4	-0.1	0.6	-0.9
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.0	-1.4	0.7	1.2	0.3	0.6	-1.4
Mood swings	0.4	0.8	1.6	-1.1	1.3	0.8	0.1	0.9	0.5
Loneliness, isolation	0.4	0.6	2.2	-1.5	0.7	0.0	0.6	0.5	0.5
Long-standing illness, disability or infirmity	0.6	0.9	2.3	1.5	-0.8	-0.4	-0.4	0.8	1.3
Ever had bowel cancer screening	1.3	1.6	4.9	0.7	-0.7	2.2	1.5	1.0	-0.4
Diabetes diagnosed by doctor	0.4	0.7	1.9	0.3	-1.2	1.4	-0.7	-0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.8	1.1	-0.5	-1.0	-0.9	-0.3	-1.4
Friendships satisfaction	0.2	0.2	0.7	0.1	-0.6	0.0	0.1	-0.8	-0.6
Qualifications: nursing, teaching	0.7	1.2	2.0	-0.3	-1.1	-0.3	-1.4	-1.4	-1.2
Commuting to job workplace: Walk	0.9	0.9	2.9	-0.3	-0.1	-1.4	-0.1	0.8	1.7
Eye problems/disorders: Cataract	0.4	0.5	1.1	1.0	-0.2	0.1	0.7	0.8	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	6.1	1.2	-2.4	0.9	2.5	0.4	1.6
Medication for cholesterol	0.7	1.0	2.9	-0.7	-0.4	1.7	-0.5	0.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	5.0	2.2	-0.1	-0.5	-0.4	0.7	-0.6
Back pain experienced in last month	0.4	0.5	1.2	0.0	1.1	0.4	0.9	1.0	0.2
Mineral and other dietary supplements	0.8	1.1	5.2	-2.3	0.4	-0.6	-0.1	-0.7	0.8
Breast cancer (self-reported)	2.3	2.8	9.6	3.1	-1.9	-0.2	1.1	0.9	1.2
Asthma (self-reported)	0.3	0.5	2.4	0.2	0.2	-1.5	-0.6	-0.1	0.4
Osteoporosis (self-reported)	0.4	0.5	1.6	1.3	0.6	-0.3	0.0	0.6	-0.6
Osteoarthritis (self-reported)	0.9	1.2	4.4	2.1	-1.5	-0.4	-0.5	0.0	-0.2
Medication: Aspirin	1.6	2.1	4.3	2.1	-1.9	-0.8	0.6	-0.6	1.8
Medication: Gliclazide	0.2	0.2	0.6	-0.4	-0.6	0.1	0.1	-0.5	-0.8
Illnesses of father: None of the above (group 1)	1.6	1.9	6.7	-0.9	2.6	0.9	-0.0	1.2	-1.3
Smoking status: Current	0.6	0.9	4.5	-2.1	0.4	-0.0	0.2	-0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.7	1.9	-1.6	1.9	-0.3	0.3	-0.7
Whole body water mass	0.3	1.8	5.2	1.3	-0.1	0.3	0.5	2.3	1.8
Leg predicted mass (right)	0.4	1.9	6.9	0.9	0.5	0.3	0.6	2.6	1.8
Arm fat mass (left)	0.5	2.1	4.4	1.4	-1.0	-0.3	2.1	1.0	2.0
Number of self-reported non-cancer illnesses	0.7	1.3	3.5	1.9	-1.5	-0.8	0.3	-1.0	-0.4
Average weekly champagne plus white wine intake	2.7	3.7	7.9	-0.8	2.7	-0.3	-2.8	0.8	-2.4
Miserableness	0.5	0.9	2.7	-0.5	1.6	1.1	0.6	0.8	-0.4
Guilty feelings	1.6	2.3	4.0	1.0	1.8	1.7	-1.5	2.0	-0.7
Wears glasses or contact lenses	1.4	1.6	4.7	1.0	-1.4	-2.2	0.5	-1.2	-0.5
Ever taken oral contraceptive pill	1.1	1.3	3.5	-1.2	0.3	-1.9	-1.3	-0.6	0.7
Hearing aid user	1.5	1.6	3.2	0.6	-1.7	-0.5	1.8	-1.4	1.2
Mother’s age at death	0.6	0.8	1.9	-0.1	0.2	1.4	1.0	-0.7	-1.0
Financial situation satisfaction	1.2	1.5	5.2	-0.5	2.3	-0.5	-1.5	0.4	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.9	-0.4	0.8	-0.4	-0.5	-0.3
Commuting to job workplace: Public transport	0.9	1.1	3.6	1.3	-0.6	-0.5	0.2	0.7	1.9
Eye problems/disorders: Glaucoma	0.8	0.9	2.5	-1.2	-0.0	0.4	1.6	-0.9	0.8
Medication: Blood pressure	0.4	0.8	3.5	0.9	0.3	0.0	0.6	0.4	1.9
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.6	2.1	-1.0	0.7	1.4	2.1	1.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	1.0	0.3	0.5	0.6	0.7	-0.2
High cholesterol (Self-reported)	1.0	1.8	5.2	1.6	0.1	-0.5	-0.5	-1.5	-2.3
Medication: Bendroflumethiazide	0.5	0.8	3.5	1.9	0.4	0.1	0.1	0.7	0.5
Medication: Paracetamol	0.3	0.5	1.3	-0.0	-0.1	1.1	0.2	0.9	-0.9
Medication: Lisinopril	1.9	2.5	7.5	0.6	2.7	1.5	0.6	1.8	-1.1
Medication: Atorvastatin	0.9	1.2	4.4	2.1	-1.5	-0.0	0.3	0.3	0.3
Illnesses of father: High blood pressure	0.3	0.4	0.7	-0.8	-0.1	0.9	-0.8	0.4	0.5
Alcohol drinker status: Never	0.2	0.2	1.0	-0.2	0.3	0.0	0.4	-1.0	0.2
Ever smoked	0.9	1.5	4.2	-2.1	2.0	0.1	-0.8	-0.0	-0.4
Basal metabolic rate	0.3	1.8	4.8	1.4	-0.3	0.2	0.7	2.2	1.9
Leg fat percentage (left)	1.0	3.7	8.9	1.6	-3.0	-1.5	2.2	-1.0	1.6
Arm fat-free mass (left)	0.3	1.5	4.0	1.4	-0.1	0.1	0.7	2.0	1.6
Number of operations (self-reported)	1.5	2.2	5.8	0.5	-2.4	0.7	2.0	-0.6	1.5
Average weekly beer plus cider intake	2.8	4.1	6.2	-1.5	-2.0	-2.5	2.0	-1.6	2.3
Irritability	0.6	1.0	2.4	-1.5	0.9	-0.8	-1.1	-0.9	0.2
Risk taking	0.3	0.5	1.3	-0.9	0.1	-1.1	-0.6	-0.1	0.7
Ever had prostate specific antigen (PSA) test	2.1	2.5	6.1	-0.1	1.4	2.5	-1.2	1.7	-1.4
Fractured/broken bones in last 5 years	0.6	0.8	1.8	-0.9	-0.9	1.3	-0.0	-0.2	-1.3
Age started oral contraceptive pill	0.7	0.9	3.3	1.8	0.5	0.5	-0.9	0.5	-0.7
Diastolic blood pressure, automated reading	0.5	1.5	2.7	1.5	-1.4	-1.7	1.1	-0.6	0.7
Ever depressed for a whole week	0.6	0.8	2.7	-0.2	0.5	0.5	-0.6	1.0	-1.6
Unable to work because of sickness or disability	0.2	0.3	1.0	0.1	-0.4	0.7	-1.0	0.1	0.1
Commuting to job workplace: Cycle	0.7	0.8	2.6	0.3	0.8	0.1	-1.6	0.8	-0.9
Myopia	0.2	0.3	1.2	-0.1	0.0	0.2	0.2	1.1	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.6	-2.1	1.3	-0.7	-0.2	-0.6	-0.9
Cholesterol lowering medication	0.3	0.4	0.9	-0.4	0.6	-0.8	-0.4	-0.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	8.1	1.2	1.3	-0.3	-1.0	2.8	0.9
Pain experienced in last month	2.2	3.7	9.2	-0.6	0.4	0.4	-2.5	-2.5	-3.0
Supplements: Calcium	1.1	1.2	4.3	2.1	0.3	-0.8	-1.1	-0.2	0.9
Basal cell carcinoma (self-reported)	0.8	0.9	2.7	-1.1	0.5	1.6	0.9	-0.7	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.5	0.7	-0.8	-0.9	-0.6	-0.2	1.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	6.0	1.6	-0.1	-1.2	-2.0	-1.3	-2.5
Heart disease (siblings)	0.2	0.3	1.2	1.1	-0.0	-0.3	0.3	0.1	-0.5
Alcohol drinker status: Previous	0.8	0.9	3.2	-0.3	1.3	0.7	-0.1	1.8	-0.2
Pack years of smoking	1.3	1.9	5.4	0.4	-1.1	-2.3	0.2	-0.7	2.0
Impedance of whole body	0.3	1.7	3.5	-1.1	1.0	-0.1	-1.8	-1.0	-1.9
Leg fat mass (left)	0.7	2.6	4.5	1.4	-1.9	-1.3	2.1	-0.2	1.9
Arm predicted mass (left)	0.3	1.6	4.2	1.3	-0.2	0.2	0.7	2.0	1.8