Hub : Genes

TMOD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0540 0.0240 0.0028 0.000 NA -0.003 NA 0.003 3.3e-01 NA 6.5e-01 NA 1.8e-01
2 GTEx Artery Coronary 0.1760 0.0740 0.0038 0.010 NA 0.108 NA 0.072 1.5e-01 NA 1.8e-04 NA 2.0e-03
3 GTEx Brain Cerebellar Hemisphere 0.3400 0.0970 0.0016 0.203 NA 0.076 NA 0.215 6.2e-06 NA 5.5e-03 NA 3.1e-06
4 GTEx Esophagus Mucosa 0.1220 0.0480 0.0023 0.044 NA 0.048 NA 0.030 6.6e-04 NA 3.7e-04 NA 4.2e-03
5 METSIM Adipose 0.0359 0.0161 0.0025 0.038 0.019 0.029 0.022 0.029 2.2e-06 0.00057 2.7e-05 0.00023 3.0e-05
6 TCGA Breast Invasive Carcinoma 0.0199 0.0117 0.0097 0.009 0.008 0.010 NA 0.006 3.8e-03 0.00620 2.4e-03 NA 1.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 1.7 -1.1 0.9 -1.3 -0.6 -0.9 -0.0
Bipolar Disorder or Schizophrenia 0.1 0.2 0.5 0.1 0.7 -0.3 -0.2 0.5 -0.5
Depressed Affect (Nagel 2018) 0.5 1.0 2.3 -1.2 1.5 0.5 0.2 1.3 0.3
Depression (Nagel 2018) 0.6 0.8 2.0 -0.2 1.4 -0.2 -1.3 0.2 -1.0
Intelligence (Savage-Jansen 2018) 1.2 3.6 11.2 0.7 -1.7 0.8 3.3 1.9 1.7
Neuroticism (Nagel 2018) 1.0 2.4 3.9 -1.1 1.9 1.9 -1.2 2.0 -1.0
Schizophrenia (2018) 0.3 0.6 1.8 0.9 0.2 0.7 0.2 1.4 -0.6
Schizophrenia vs Biploar Disorder 0.2 0.3 1.5 -0.1 0.2 0.4 0.4 1.2 0.3
Worry (Nagel 2018) 0.5 1.0 2.6 -1.1 0.6 1.3 -1.6 0.6 -0.3
Alzheimer’s Disease (in mother) 0.6 0.6 2.2 1.5 -0.1 1.0 0.7 0.4 -0.1
Alzheimer’s Disease (in father) 0.8 0.8 3.2 -1.8 0.5 -0.1 0.7 -0.7 0.7
Alzheimer’s Disease (including proxy) 0.2 0.4 1.1 -0.1 0.4 0.6 1.1 0.1 0.7
Crohns Disease (2017) 0.4 0.8 1.5 -0.4 1.1 0.2 0.5 1.2 1.2
Irritable Bowel Disease (IBD) 0.4 0.9 3.6 -0.3 1.9 -0.2 -0.5 1.1 0.4
Ulcerative Colitis (UC) 0.6 1.2 4.0 -0.5 2.0 -0.6 -1.5 0.3 -0.3
Major Depression (MDD) 0.5 0.7 2.1 -0.4 -0.5 -0.9 0.8 0.3 1.5
Reaction Time 0.6 1.1 3.6 0.2 1.7 -0.2 -1.9 0.3 -0.6
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.7 0.3 -0.8 1.1 1.9 1.5 1.6
Breast Cancer 0.2 0.5 1.5 0.8 0.4 -1.2 0.2 -0.5 -0.3
Ovarian Cancer 0.2 0.2 0.9 -1.0 -0.3 -0.3 0.2 -0.6 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.8 1.1 2.4 -0.3 0.7 0.8 -0.9 1.5 -1.5
Bipolar Disorder (2011) 2.4 2.3 5.1 -0.2 0.4 -0.8 -2.2 -2.1 -1.8
Body Mass Index (BMI) (2010) 0.7 1.0 2.7 -0.7 0.8 -1.6 -1.2 -0.2 -0.7
Coronary Artery Disease (CAD) 1.3 1.5 4.1 0.8 0.0 -0.4 1.8 1.1 2.0
Crohns Disease (2012) 0.4 0.7 1.5 -1.2 0.8 0.3 0.7 0.6 0.9
Mean Putamen Volume 0.5 0.6 2.1 -1.4 0.6 0.8 0.5 0.2 0.0
Fasting Glucose 1.8 2.2 8.6 2.9 -0.6 0.6 0.0 2.0 0.1
HbA1C 2.3 2.5 5.1 -1.5 0.8 1.2 -2.2 -0.9 -2.2
HDL Cholesterol 0.5 0.9 3.5 -0.1 1.1 -0.7 -1.9 0.4 -0.0
LDL Cholesterol 0.2 0.3 0.8 0.7 -0.9 0.6 -0.2 -0.1 -0.3
Lupus 0.6 1.0 3.2 -0.8 1.1 -0.1 0.7 1.8 0.6
Neuroticism (2016) 1.3 1.9 4.9 -1.0 2.2 1.4 -0.1 1.4 -1.1
Primary Biliary Cirrhosis 1.8 2.6 7.3 -0.2 2.7 0.9 -1.8 0.9 -1.9
Rheumatoid Arthritis 0.4 0.6 1.9 -0.3 -0.8 -1.4 -0.4 -0.4 0.7
Schizophrenia (2014) 0.0 0.1 0.5 0.0 0.0 -0.0 -0.0 0.3 -0.7
Triglycerides 1.4 2.4 9.5 -0.2 -1.6 0.6 3.1 -1.2 0.7
Type 2 Diabetes (T2D) (2012) 1.5 1.7 3.1 -1.7 1.8 -0.5 -0.2 -1.4 -1.3
Ulcerative Colitis 0.2 0.3 1.1 0.2 1.0 -0.6 0.2 0.1 -0.3
Blood Eosinophil Count 0.1 0.8 1.9 0.9 0.8 0.6 -0.8 0.5 1.4
Blood Platelet Count 1.7 19.7 34.8 -5.5 5.1 -0.2 -5.9 -2.2 -4.6
Blood Red Count 0.2 2.2 5.0 0.3 -2.0 1.6 2.2 0.9 0.9
Blood White Count 0.4 3.1 8.0 -0.4 -2.2 -2.4 -0.3 -2.8 -0.0
Heel T-Score 0.3 2.6 7.3 -0.2 -1.9 -0.9 -0.9 -2.7 -1.8
BMI 0.1 0.9 3.0 -0.1 0.1 -0.9 1.7 0.8 0.8
Height 0.7 14.3 35.6 5.1 2.7 3.1 -2.4 6.0 1.0
Waist Hip Ratio (WHR) 0.3 1.5 3.4 -1.8 -0.4 -0.6 -1.2 -0.6 1.8
Systolic Blood Pressure 0.2 1.2 2.9 1.1 -1.1 -0.5 -1.7 -1.1 -0.4
Smoking Status 0.2 0.5 1.1 -0.7 1.1 -0.6 -0.6 -0.0 -0.8
Allergy or Eczema 0.5 1.3 5.0 2.2 -0.5 1.2 0.7 0.1 -0.6
Cardiovascular Disease 0.1 0.5 1.3 1.1 0.1 -0.8 -0.5 -0.5 0.6
Hypothyroidism (self reported) 8.9 20.5 49.4 -0.5 -7.0 -1.1 6.3 -5.4 -1.8
Respiratory disease 0.6 1.3 4.0 -0.0 -0.8 -2.0 -1.7 -0.4 -0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.4 -0.5 -0.5 0.8 -1.2 -0.1 0.1
Lung FEV1/FVC ratio 1.1 5.5 18.0 4.2 1.5 1.5 -0.2 3.2 0.5
Lung FVC 0.3 1.7 6.4 0.9 -1.2 0.7 0.3 -1.1 -2.5
Neuroticism 0.6 1.4 3.2 0.1 1.8 1.0 -0.9 1.8 0.5
Chronotype (morning person) 1.3 3.1 7.3 0.7 2.0 -0.8 -2.7 0.7 -2.3
Hair Pigment 0.3 9.1 21.6 -0.1 -3.8 -4.7 3.4 -2.6 0.5
Tanning 0.1 0.7 1.8 -1.3 -0.3 -0.8 -0.4 -0.3 1.3
Hand grip strength (left) 0.7 1.7 3.9 -2.0 1.1 -1.2 -1.8 -0.7 -0.0
Number of treatments/medications taken 0.9 1.7 4.7 2.2 -0.8 -0.6 1.3 0.4 1.5
Average weekly spirits intake 1.1 1.3 2.8 0.5 1.3 1.7 -1.2 1.4 -0.3
Sensitivity / hurt feelings 0.9 1.5 3.6 -1.1 1.9 1.0 -1.0 0.9 -1.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.7 -0.2 1.6 0.9 -0.4 0.8 -0.2
Hearing difficulty/problems: Yes 1.7 2.6 9.3 3.0 -0.5 0.2 0.9 2.1 -0.6
Relative age of first facial hair 0.2 0.3 1.4 0.4 1.2 -0.3 -0.5 0.2 0.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 4.1 0.8 -0.5 -0.7 0.5 1.1 2.0
Ever used hormone-replacement therapy (HRT) 1.0 1.2 4.1 2.0 -0.5 0.2 -1.7 -0.3 -0.1
Ever had hysterectomy (womb removed) 0.3 0.3 0.5 -0.6 0.7 0.5 0.2 -0.7 0.3
Systolic blood pressure, automated reading 0.2 0.6 1.3 1.1 -0.9 -1.0 0.4 -0.8 -0.1
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 -0.5 0.6 0.8 0.4 0.6 0.2
Angina 0.3 0.4 2.0 -0.1 -0.2 0.1 -1.4 -0.1 0.3
Medication for hormone replacement therapy 0.6 0.7 3.1 0.3 -0.1 -1.8 -0.6 0.1 0.6
Vitamin and mineral supplements 2.4 3.2 6.4 -2.5 -1.9 -1.9 1.6 -1.6 0.6
Supplements: Zinc 2.1 2.3 7.3 0.7 -1.9 -2.7 0.1 -0.4 1.5
Medication: Co-codamol 0.5 0.5 1.6 1.3 0.4 -0.7 0.4 0.5 0.8
Medication: Metformin 0.6 0.8 2.6 0.8 -1.0 1.6 0.0 0.8 0.1
Diabetes (father) 0.6 0.7 2.1 0.0 -1.4 -0.7 0.2 -1.1 0.5
Diabetes (mother) 0.5 0.6 2.6 -0.6 -0.7 0.0 -0.5 -0.1 1.6
Severe depression (siblings) 0.3 0.3 0.6 0.1 -0.8 0.4 0.6 0.1 0.8
Pack years adult smoking proportion 1.2 1.9 5.2 -0.1 -0.9 -2.3 0.4 -0.7 2.1
Impedance of leg (right) 0.5 2.4 6.4 -0.8 -1.1 -1.3 -1.4 -2.5 -1.5
Leg fat-free mass (left) 0.3 1.7 4.7 0.9 0.1 0.2 0.9 2.2 1.9
Trunk fat percentage 0.3 1.0 2.8 1.1 -0.9 -0.2 1.7 0.5 1.1
Hand grip strength (right) 0.6 1.7 4.6 -1.4 0.7 -0.4 -2.2 -0.8 -1.5
Townsend deprivation index at recruitment 0.5 0.7 1.4 -1.0 -0.3 -1.1 -0.0 -0.5 1.2
Current tobacco smoking 0.3 0.5 2.5 -1.6 -0.0 0.1 0.3 -0.3 0.8
Average weekly fortified wine intake 0.3 0.4 1.3 0.4 0.4 -1.1 -0.2 -0.3 0.6
Maternal smoking around birth 0.8 1.1 1.7 1.1 -0.9 0.5 1.1 1.2 1.3
Fed-up feelings 0.7 1.2 2.1 -1.2 1.4 -0.7 1.4 0.7 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.8 0.7 1.3 0.4 -0.1 0.4 -0.4
Relative age voice broke 1.1 1.7 4.7 -0.6 2.2 -0.5 -1.8 -0.5 -1.1
Taking other prescription medications 0.7 1.1 4.1 2.0 -1.3 0.2 0.9 0.4 0.1
Age when periods started (menarche) 0.3 0.8 2.6 1.1 -0.3 -0.4 1.6 -0.9 -0.0
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.8 0.5 0.9 0.3 -0.1 1.3 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 5.8 -0.5 1.1 -2.3 -2.4 -1.2 -0.2
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.7 -1.2 1.3 0.3 -0.6 -0.1 -1.0
Qualifications: CSEs or equivalent 1.8 2.4 4.0 2.0 -1.1 -0.9 1.8 1.8 1.4
Serious illness, injury or assault to yourself 0.7 0.8 2.1 -1.0 1.0 -0.0 0.5 0.9 1.5
High blood pressure 0.6 1.6 5.9 2.4 -1.0 1.3 0.5 0.9 0.4
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.7 1.6 -0.7 0.8 1.1 -0.1 -0.1
Multivitamins +/- minerals 1.5 1.9 4.1 2.0 1.0 1.6 -0.5 1.9 0.1
Stomach or abdominal pain in last month 0.5 0.6 1.4 0.3 1.1 0.4 -0.4 0.8 1.2
Supplements: Glucosamine 0.7 0.9 3.3 1.8 -0.4 0.5 1.1 0.6 -0.2
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.5 0.3 -1.3 0.1 1.0 -0.4 1.6
Medication: Atenolol 0.7 0.8 1.9 1.4 -1.0 0.1 -0.6 -0.8 1.0
Medication: Levothyroxine sodium 6.7 11.4 26.2 -0.4 -5.1 -0.9 4.8 -4.1 -1.3
Sitting height 0.2 1.7 3.8 0.8 0.1 -0.0 -1.5 2.0 1.8
Chronic bronchitis/emphysema (father) 0.7 0.8 1.8 0.9 -0.6 -0.1 0.9 0.9 1.4
High blood pressure (mother) 0.8 1.1 2.3 -1.5 1.5 -0.2 0.6 0.8 1.0
Body mass index (BMI) 0.5 2.0 5.3 1.1 -1.4 -0.7 2.3 0.3 1.8
Impedance of leg (left) 0.5 2.2 4.5 -0.8 -0.5 -1.5 -1.7 -2.1 -1.7
Leg predicted mass (left) 0.3 1.6 4.4 0.9 0.1 0.1 0.8 2.1 1.9
Trunk fat mass 0.4 1.6 2.9 1.5 -1.1 -0.3 1.6 0.9 1.7
Waist circumference 0.6 2.1 4.7 1.1 -2.2 -0.7 1.7 -0.3 1.9
Number of incorrect matches in round 0.7 1.2 3.1 0.9 1.2 -0.6 -1.8 -1.1 -0.5
Past tobacco smoking 0.6 1.1 3.9 1.0 -2.0 -0.2 0.9 -0.6 0.9
Alcohol usually taken with meals 3.9 6.3 13.6 1.4 3.2 1.7 -2.7 1.4 -3.7
Nervous feelings 0.6 1.0 3.4 -0.0 0.2 1.8 -0.5 1.0 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 3.8 -0.0 1.0 0.3 -1.9 0.1 -0.5
Hearing difficulty/problems with background noise 2.1 3.3 10.0 2.6 1.5 0.4 -0.6 3.2 0.1
Hair/balding pattern: Pattern 2 0.7 0.8 3.2 -1.2 -0.2 0.2 -0.3 0.4 1.8
Had menopause 2.5 3.1 8.9 3.0 1.5 0.6 0.1 2.6 0.2
Had other major operations 2.3 2.8 10.7 3.3 -2.0 -0.1 1.5 -0.0 -0.1
Forced vital capacity (FVC) 0.1 0.4 1.4 -0.1 0.1 0.1 -1.2 0.6 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.8 0.4 0.9 -1.1 -2.0 -0.7 -0.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.0 1.4 0.1 -0.5 0.0 1.1 -1.1
Qualifications: None of the above 0.5 1.1 3.5 1.9 0.6 -0.3 0.4 1.1 1.0
Financial difficulties in last 2 years 1.0 1.4 3.1 -1.5 1.8 0.3 -1.6 0.7 -0.1
Mouth/teeth dental problems 1.5 2.3 4.5 -0.9 0.7 -0.9 -2.0 -2.1 -1.7
Heart attack 0.7 1.0 2.9 0.6 -0.8 -1.1 -0.8 -0.2 1.7
Allergy 0.4 0.9 3.5 -1.9 1.1 0.3 -0.6 0.2 0.1
Pain all over the body in last month 0.9 1.0 2.6 1.6 -1.4 -0.5 0.4 0.8 -0.5
Diabetes (self-reported) 0.3 0.5 1.9 0.1 -1.4 1.1 -0.1 -0.2 0.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 3.5 1.9 -0.7 1.0 0.3 0.3 -1.1
Medication: Ramipril 1.7 2.2 4.4 0.8 -1.4 -1.4 2.1 -1.7 1.1
Medication: Simvastatin 0.1 0.2 0.7 0.3 0.8 -0.1 -0.2 -0.6 -0.4
Fluid intelligence score 1.0 2.1 3.2 -0.3 -1.1 1.3 1.8 1.8 1.7
Illnesses of siblings 0.5 0.7 1.7 -0.5 -1.3 0.0 -0.7 -0.9 -1.1
Neuroticism score 0.4 0.8 2.1 -0.3 1.2 1.5 -0.3 1.0 0.5
Weight 0.4 1.9 3.4 1.8 -0.8 -0.1 1.3 1.6 1.8
Impedance of arm (right) 0.4 1.7 3.4 -1.2 1.8 1.0 -1.0 0.3 -1.9
Arm fat percentage (right) 0.4 1.5 4.5 1.2 -1.1 -0.3 2.1 0.5 1.3
Trunk fat-free mass 0.3 1.6 4.8 1.5 -0.3 0.6 0.3 2.2 1.5
Hip circumference 0.6 2.5 4.5 2.1 -1.9 -0.6 2.1 0.4 1.5
Time employed in main current job 0.6 0.7 2.6 1.1 0.2 -1.6 -0.1 -0.3 0.5
Alcohol intake versus 10 years previously 1.1 1.6 5.3 0.1 -1.3 -0.1 2.3 1.0 1.4
Father’s age at death 0.7 1.0 3.0 1.5 0.0 1.7 -0.7 0.3 0.1
Worrier / anxious feelings 0.6 1.2 4.2 -0.6 0.8 1.1 -2.1 0.7 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.8 -0.9 0.0 -0.6 0.6 -0.9 0.4
Falls in the last year 1.7 2.3 6.4 0.4 0.5 2.5 -1.1 1.4 -2.0
Hair/balding pattern: Pattern 3 0.5 0.7 1.6 -0.2 0.7 1.1 -0.8 -0.7 -1.3
Number of live births 0.8 1.2 3.3 1.8 -0.7 -0.6 -1.1 -1.0 -0.8
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.6 1.1 0.5 0.2 -1.3 1.2 -0.7
Pulse rate 0.3 0.5 1.2 -0.2 0.8 0.4 1.1 0.6 0.8
Happiness 0.6 0.7 1.7 -0.7 1.3 0.3 -1.3 -0.6 0.3
Noisy workplace 1.6 1.9 4.7 -0.6 -2.1 -0.9 1.1 -2.2 0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.7 4.0 -1.3 0.3 2.0 -1.7 -0.3 -1.2
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 6.3 1.9 -0.1 0.7 -0.2 2.5 -0.8
Mouth/teeth dental problems: Dentures 0.4 0.7 2.6 0.6 0.1 0.7 0.7 1.6 -0.5
Asthma 0.3 0.6 3.0 0.0 0.0 -1.7 -0.5 -0.2 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 5.6 -0.8 -1.2 -0.1 1.3 0.4 2.4
Medication: Cholesterol lowering 0.2 0.3 0.8 0.9 0.4 0.0 0.2 0.2 0.7
Depression (self-reported) 0.3 0.4 1.2 0.3 -0.3 -0.5 -0.2 -0.7 1.1
Medication: Lansoprazole 2.6 3.0 7.7 2.8 0.3 -0.5 1.3 2.6 1.3
Prospective memory result 0.5 0.7 1.6 1.3 0.0 -1.3 0.1 -0.5 -0.7
Lung cancer (father) 1.0 1.1 2.2 1.5 -1.3 0.9 1.0 0.7 0.8
Illnesses of mother 0.3 0.4 1.3 0.4 -0.5 -0.5 -0.0 -1.2 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.5 0.5 -0.1 0.8 -1.0 0.9 -1.2
Pulse wave Arterial Stiffness index 0.2 0.3 0.9 -0.1 0.2 -1.0 0.2 -0.7 -0.3
Impedance of arm (left) 0.3 1.5 3.2 -0.6 1.5 0.8 -1.5 -0.1 -1.8
Arm fat mass (right) 0.5 2.0 4.9 1.2 -0.8 -0.0 2.2 1.1 1.9
Trunk predicted mass 0.3 1.7 5.1 1.6 -0.3 0.6 0.3 2.2 1.5
Standing height 0.3 3.0 8.6 1.7 1.1 1.4 -1.8 2.9 0.7
Length of working week for main job 0.3 0.3 0.9 0.4 0.2 -1.0 -0.1 -0.0 0.8
Exposure to tobacco smoke at home 0.5 0.6 1.4 0.6 1.2 0.6 -0.3 1.0 -0.5
Breastfed as a baby 0.2 0.3 0.8 0.2 0.0 0.3 -0.9 0.2 -0.8
Tense / ‘highly strung’ 0.5 0.8 2.4 -0.1 0.2 -0.8 -1.3 0.4 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.3 0.5 -0.6 0.0 -0.0 -0.3 0.3
Hair/balding pattern: Pattern 4 0.3 0.8 2.7 1.6 -0.5 -0.8 -0.3 1.0 -0.5
Birth weight of first child 0.6 1.0 3.7 -0.9 -1.9 -0.1 1.2 0.2 0.1
Peak expiratory flow (PEF) 0.3 0.6 1.6 0.8 0.3 -0.5 -1.3 0.5 -0.8
Pulse wave reflection index 0.3 0.3 1.1 -1.0 0.0 -0.3 -0.2 -0.4 -0.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.8 0.9 0.1 -0.1 0.5 0.8 0.1
Loud music exposure frequency 0.6 0.6 1.1 -0.8 0.9 0.3 0.8 -1.1 -0.8
Qualifications: O levels/GCSEs or equivalent 1.5 2.3 6.4 -1.5 -0.8 1.8 -0.1 -1.2 -2.5
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 4.4 -0.4 0.9 -0.1 1.5 1.7 2.1
Blood clot in the leg (DVT) 1.8 2.3 5.8 1.3 0.2 -1.2 -2.0 -1.0 -2.4
Medication: Paracetamol 0.4 0.7 2.6 0.1 -0.8 1.6 0.6 0.5 -0.6
Headache pain in last month 0.4 0.7 1.5 -0.1 -1.0 0.8 -0.1 1.0 1.2
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 5.4 -2.3 0.2 -0.1 0.2 -0.6 -0.9
Glaucoma (self-reported) 0.9 1.1 3.0 -0.3 -0.5 -0.2 1.7 -1.4 1.1
Gout (self-reported) 0.5 0.7 1.8 -0.9 1.0 -0.4 1.3 -0.1 -0.8
Hypothyroidism/myxoedema (self-reported) 8.3 16.2 36.7 -1.0 -6.1 -1.0 5.2 -5.3 -1.9
Medication: Amlodipine 0.7 1.0 2.4 1.2 -0.8 -1.0 0.6 0.1 1.6
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.9 -1.7 -1.2 -0.8 -0.2 -1.2 0.1
Birth weight 0.5 1.2 2.8 -0.2 -1.7 -1.4 1.3 -0.3 0.8
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.5 0.1 -0.5 0.1 -0.1 -0.7 0.4
High blood pressure (siblings) 1.1 1.6 4.5 0.1 1.6 -0.3 1.0 1.1 2.1
Forced vital capacity (FVC), Best measure 0.2 0.7 2.0 -0.6 -0.5 0.2 -1.2 -0.1 -1.4
Body fat percentage 0.4 1.6 3.6 1.4 -1.4 -0.8 1.9 0.0 1.2
Leg fat percentage (right) 1.2 4.4 11.6 1.7 -3.4 -1.3 2.4 -1.4 1.5
Arm fat-free mass (right) 0.3 1.4 3.2 1.4 -0.7 -0.6 0.3 1.5 1.8
Exposure to tobacco smoke outside home 1.1 1.4 6.9 -1.0 -0.3 -0.2 2.6 0.1 0.6
Comparative body size at age 10 0.4 1.1 4.2 -1.4 0.4 0.4 2.0 0.6 0.0
Number of full brothers 1.3 1.6 6.7 0.2 -0.2 0.2 2.6 0.7 1.6
Worry too long after embarrassment 0.9 1.6 3.5 0.3 0.9 1.9 -1.2 1.4 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.0 0.3 -0.5 -0.4 0.1 -0.4 1.0
Wheeze or whistling in the chest in last year 0.3 0.6 2.1 -1.0 1.4 -0.0 0.0 0.6 0.2
Number of children fathered 1.3 1.5 5.0 -0.2 -0.4 -2.2 -1.5 -1.2 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.6 3.1 8.8 0.5 -3.0 -0.8 -0.6 -2.5 -1.5
Age at first live birth 1.4 2.4 4.1 -1.1 1.6 1.4 -2.0 1.0 -1.9
Pulse wave peak to peak time 0.4 0.5 1.5 0.3 -0.1 1.2 -0.2 1.1 0.4
Health satisfaction 0.2 0.3 0.7 -0.6 -0.9 0.3 0.4 -0.7 0.1
Shortness of breath walking on level ground 0.2 0.2 0.7 -0.0 -0.3 -0.1 0.8 0.2 0.6
Qualifications: College or University degree 1.0 3.1 10.1 -0.8 0.6 1.7 -3.2 -0.6 -1.9
Eye problems/disorders: None of the above 0.5 0.6 2.0 -0.9 0.6 -0.1 -1.4 -0.6 -0.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 -0.6 -0.0 -0.2 -0.5 -0.2 -0.0
Emphysema/chronic bronchitis 1.2 1.4 3.9 -0.7 0.2 -1.7 0.3 0.8 2.0
Medication for pain relief, constipation, heartburn 0.9 1.5 3.5 -1.8 1.4 0.3 -0.1 -0.2 -1.9
Neck or shoulder pain in last month 1.6 2.3 7.7 0.8 -1.2 -0.0 2.8 1.2 1.6
Medication: Blood pressure 0.9 1.5 6.0 2.4 -1.0 0.0 -0.0 0.7 1.3
Angina (self-reported) 0.4 0.5 2.4 -0.1 -0.4 -0.2 -1.6 -0.2 0.7
Migraine (self-reported) 0.6 0.7 1.8 0.9 -1.4 0.7 -0.4 0.6 -0.8
Medication: Ibuprofen 0.9 1.1 3.6 -1.3 -0.0 0.1 0.4 1.2 1.9
Medication: Allopurinol 0.1 0.2 0.5 -0.3 0.7 0.3 0.4 -0.0 -0.5
Medication: Omeprazole 1.4 1.7 4.3 0.2 1.1 -1.5 -2.1 1.3 0.5
Medication: Seretide 50 evohaler 1.3 1.5 3.0 -1.6 -1.7 -0.2 -0.7 -1.0 1.4
Mean time to correctly identify matches 0.9 1.7 4.6 2.1 0.7 1.0 -1.8 0.3 -1.0
Heart disease (mother) 0.8 1.0 4.3 -2.1 0.0 -1.1 -0.2 -0.5 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.2 0.9 -1.1 -0.4 -0.3 -0.7 -0.9
Whole body fat mass 0.4 1.6 3.0 1.5 -1.1 -0.6 1.6 0.8 1.7
Leg fat mass (right) 0.8 3.0 5.4 1.7 -2.3 -1.2 2.3 -0.3 1.8
Arm predicted mass (right) 0.3 1.5 3.2 1.6 -0.6 -0.3 0.4 1.8 1.6
Pulse rate, automated reading 0.2 0.7 2.5 0.3 -0.1 0.7 1.1 1.6 0.1
Alcohol intake frequency. 0.3 0.6 3.0 -0.1 0.1 -1.7 0.2 -0.2 0.9
Comparative height size at age 10 0.9 4.7 12.3 2.3 2.2 2.4 -0.6 3.5 0.3
Number of full sisters 0.3 0.4 1.3 -0.4 -0.3 -0.2 -1.0 -1.1 -0.1
Suffer from ‘nerves’ 0.8 1.2 4.9 0.6 0.2 2.2 0.1 1.4 0.3
Overall health rating 0.1 0.3 0.9 1.0 0.0 -0.5 -0.0 -0.6 0.6
Chest pain or discomfort 0.3 0.4 1.1 1.1 -0.7 0.3 -0.1 0.8 0.3
Had major operations 2.5 3.0 7.3 -1.6 -2.7 -0.2 1.6 -1.8 1.4
Age at last live birth 1.7 2.5 8.3 -1.2 1.1 0.9 -2.9 0.4 -1.7
Family relationship satisfaction 0.4 0.5 1.2 -0.8 -0.1 -0.7 1.1 -0.7 -0.1
Leg pain on walking 0.2 0.3 0.9 1.0 -0.2 0.0 -0.6 0.2 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.1 -0.7 0.7 -1.0 0.1 -0.3 0.9
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.6 -0.3 -0.7 -0.4 0.3 -1.3 -0.7
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.6 -0.1 -1.3 -0.3 -0.2 -1.2 0.2
Medication: Aspirin 1.7 2.3 5.2 2.3 -2.0 -0.7 0.5 -0.5 1.8
Supplements: Vitamin C 0.8 1.0 3.5 1.9 0.8 0.7 -0.2 1.1 0.3
Knee pain experienced in last month 1.7 2.6 5.3 0.6 -0.7 1.4 2.3 1.8 2.0
Hypertension (Self-reported) 0.4 1.2 2.8 1.7 -0.7 1.1 1.0 0.9 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.4 -0.3 -0.0 -1.9 -1.4 0.0 0.2
Illnesses of father: Heart disease 0.9 1.3 3.6 0.7 -1.9 -1.0 0.4 -1.0 1.2
Illnesses of siblings: Diabetes 0.5 0.6 1.5 -1.0 -0.6 1.2 -0.7 -0.3 -0.1
Smoking status: Previous 0.3 0.4 1.1 0.4 0.8 0.2 -0.6 0.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.8 -1.0 0.8 -1.3 -0.2 0.6 0.0
Whole body fat-free mass 0.3 1.8 5.4 1.4 -0.1 0.4 0.5 2.3 1.7
Leg fat-free mass (right) 0.4 2.0 7.4 0.9 0.5 0.3 0.6 2.7 1.8
Arm fat percentage (left) 0.5 1.9 4.5 1.3 -1.5 -0.6 2.1 0.2 1.5
Average weekly red wine intake 0.2 0.3 0.8 0.8 0.2 0.4 -0.1 0.6 -0.9
Handedness (chirality/laterality): Left-handed 0.9 1.0 2.0 -1.4 0.7 1.2 0.3 0.6 -1.4
Mood swings 0.4 0.8 1.6 -1.1 1.3 0.8 0.1 0.9 0.5
Loneliness, isolation 0.4 0.6 2.2 -1.5 0.7 0.0 0.6 0.5 0.5
Long-standing illness, disability or infirmity 0.6 0.9 2.3 1.5 -0.8 -0.4 -0.4 0.8 1.3
Ever had bowel cancer screening 1.3 1.6 4.9 0.7 -0.7 2.2 1.5 1.0 -0.4
Diabetes diagnosed by doctor 0.4 0.7 1.9 0.3 -1.2 1.4 -0.7 -0.3 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.8 1.1 -0.5 -1.0 -0.9 -0.3 -1.4
Friendships satisfaction 0.2 0.2 0.7 0.1 -0.6 0.0 0.1 -0.8 -0.6
Qualifications: nursing, teaching 0.7 1.2 2.0 -0.3 -1.1 -0.3 -1.4 -1.4 -1.2
Commuting to job workplace: Walk 0.9 0.9 2.9 -0.3 -0.1 -1.4 -0.1 0.8 1.7
Eye problems/disorders: Cataract 0.4 0.5 1.1 1.0 -0.2 0.1 0.7 0.8 -0.8
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 6.1 1.2 -2.4 0.9 2.5 0.4 1.6
Medication for cholesterol 0.7 1.0 2.9 -0.7 -0.4 1.7 -0.5 0.3 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 5.0 2.2 -0.1 -0.5 -0.4 0.7 -0.6
Back pain experienced in last month 0.4 0.5 1.2 0.0 1.1 0.4 0.9 1.0 0.2
Mineral and other dietary supplements 0.8 1.1 5.2 -2.3 0.4 -0.6 -0.1 -0.7 0.8
Breast cancer (self-reported) 2.3 2.8 9.6 3.1 -1.9 -0.2 1.1 0.9 1.2
Asthma (self-reported) 0.3 0.5 2.4 0.2 0.2 -1.5 -0.6 -0.1 0.4
Osteoporosis (self-reported) 0.4 0.5 1.6 1.3 0.6 -0.3 0.0 0.6 -0.6
Osteoarthritis (self-reported) 0.9 1.2 4.4 2.1 -1.5 -0.4 -0.5 0.0 -0.2
Medication: Aspirin 1.6 2.1 4.3 2.1 -1.9 -0.8 0.6 -0.6 1.8
Medication: Gliclazide 0.2 0.2 0.6 -0.4 -0.6 0.1 0.1 -0.5 -0.8
Illnesses of father: None of the above (group 1) 1.6 1.9 6.7 -0.9 2.6 0.9 -0.0 1.2 -1.3
Smoking status: Current 0.6 0.9 4.5 -2.1 0.4 -0.0 0.2 -0.3 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.7 1.9 -1.6 1.9 -0.3 0.3 -0.7
Whole body water mass 0.3 1.8 5.2 1.3 -0.1 0.3 0.5 2.3 1.8
Leg predicted mass (right) 0.4 1.9 6.9 0.9 0.5 0.3 0.6 2.6 1.8
Arm fat mass (left) 0.5 2.1 4.4 1.4 -1.0 -0.3 2.1 1.0 2.0
Number of self-reported non-cancer illnesses 0.7 1.3 3.5 1.9 -1.5 -0.8 0.3 -1.0 -0.4
Average weekly champagne plus white wine intake 2.7 3.7 7.9 -0.8 2.7 -0.3 -2.8 0.8 -2.4
Miserableness 0.5 0.9 2.7 -0.5 1.6 1.1 0.6 0.8 -0.4
Guilty feelings 1.6 2.3 4.0 1.0 1.8 1.7 -1.5 2.0 -0.7
Wears glasses or contact lenses 1.4 1.6 4.7 1.0 -1.4 -2.2 0.5 -1.2 -0.5
Ever taken oral contraceptive pill 1.1 1.3 3.5 -1.2 0.3 -1.9 -1.3 -0.6 0.7
Hearing aid user 1.5 1.6 3.2 0.6 -1.7 -0.5 1.8 -1.4 1.2
Mother’s age at death 0.6 0.8 1.9 -0.1 0.2 1.4 1.0 -0.7 -1.0
Financial situation satisfaction 1.2 1.5 5.2 -0.5 2.3 -0.5 -1.5 0.4 -0.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 0.9 -0.4 0.8 -0.4 -0.5 -0.3
Commuting to job workplace: Public transport 0.9 1.1 3.6 1.3 -0.6 -0.5 0.2 0.7 1.9
Eye problems/disorders: Glaucoma 0.8 0.9 2.5 -1.2 -0.0 0.4 1.6 -0.9 0.8
Medication: Blood pressure 0.4 0.8 3.5 0.9 0.3 0.0 0.6 0.4 1.9
Pain type(s) experienced in last month: Hip pain 1.9 2.4 4.6 2.1 -1.0 0.7 1.4 2.1 1.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 1.0 0.3 0.5 0.6 0.7 -0.2
High cholesterol (Self-reported) 1.0 1.8 5.2 1.6 0.1 -0.5 -0.5 -1.5 -2.3
Medication: Bendroflumethiazide 0.5 0.8 3.5 1.9 0.4 0.1 0.1 0.7 0.5
Medication: Paracetamol 0.3 0.5 1.3 -0.0 -0.1 1.1 0.2 0.9 -0.9
Medication: Lisinopril 1.9 2.5 7.5 0.6 2.7 1.5 0.6 1.8 -1.1
Medication: Atorvastatin 0.9 1.2 4.4 2.1 -1.5 -0.0 0.3 0.3 0.3
Illnesses of father: High blood pressure 0.3 0.4 0.7 -0.8 -0.1 0.9 -0.8 0.4 0.5
Alcohol drinker status: Never 0.2 0.2 1.0 -0.2 0.3 0.0 0.4 -1.0 0.2
Ever smoked 0.9 1.5 4.2 -2.1 2.0 0.1 -0.8 -0.0 -0.4
Basal metabolic rate 0.3 1.8 4.8 1.4 -0.3 0.2 0.7 2.2 1.9
Leg fat percentage (left) 1.0 3.7 8.9 1.6 -3.0 -1.5 2.2 -1.0 1.6
Arm fat-free mass (left) 0.3 1.5 4.0 1.4 -0.1 0.1 0.7 2.0 1.6
Number of operations (self-reported) 1.5 2.2 5.8 0.5 -2.4 0.7 2.0 -0.6 1.5
Average weekly beer plus cider intake 2.8 4.1 6.2 -1.5 -2.0 -2.5 2.0 -1.6 2.3
Irritability 0.6 1.0 2.4 -1.5 0.9 -0.8 -1.1 -0.9 0.2
Risk taking 0.3 0.5 1.3 -0.9 0.1 -1.1 -0.6 -0.1 0.7
Ever had prostate specific antigen (PSA) test 2.1 2.5 6.1 -0.1 1.4 2.5 -1.2 1.7 -1.4
Fractured/broken bones in last 5 years 0.6 0.8 1.8 -0.9 -0.9 1.3 -0.0 -0.2 -1.3
Age started oral contraceptive pill 0.7 0.9 3.3 1.8 0.5 0.5 -0.9 0.5 -0.7
Diastolic blood pressure, automated reading 0.5 1.5 2.7 1.5 -1.4 -1.7 1.1 -0.6 0.7
Ever depressed for a whole week 0.6 0.8 2.7 -0.2 0.5 0.5 -0.6 1.0 -1.6
Unable to work because of sickness or disability 0.2 0.3 1.0 0.1 -0.4 0.7 -1.0 0.1 0.1
Commuting to job workplace: Cycle 0.7 0.8 2.6 0.3 0.8 0.1 -1.6 0.8 -0.9
Myopia 0.2 0.3 1.2 -0.1 0.0 0.2 0.2 1.1 -0.8
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.6 -2.1 1.3 -0.7 -0.2 -0.6 -0.9
Cholesterol lowering medication 0.3 0.4 0.9 -0.4 0.6 -0.8 -0.4 -0.9 -0.7
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 8.1 1.2 1.3 -0.3 -1.0 2.8 0.9
Pain experienced in last month 2.2 3.7 9.2 -0.6 0.4 0.4 -2.5 -2.5 -3.0
Supplements: Calcium 1.1 1.2 4.3 2.1 0.3 -0.8 -1.1 -0.2 0.9
Basal cell carcinoma (self-reported) 0.8 0.9 2.7 -1.1 0.5 1.6 0.9 -0.7 0.3
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.5 0.7 -0.8 -0.9 -0.6 -0.2 1.6
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 6.0 1.6 -0.1 -1.2 -2.0 -1.3 -2.5
Heart disease (siblings) 0.2 0.3 1.2 1.1 -0.0 -0.3 0.3 0.1 -0.5
Alcohol drinker status: Previous 0.8 0.9 3.2 -0.3 1.3 0.7 -0.1 1.8 -0.2
Pack years of smoking 1.3 1.9 5.4 0.4 -1.1 -2.3 0.2 -0.7 2.0
Impedance of whole body 0.3 1.7 3.5 -1.1 1.0 -0.1 -1.8 -1.0 -1.9
Leg fat mass (left) 0.7 2.6 4.5 1.4 -1.9 -1.3 2.1 -0.2 1.9
Arm predicted mass (left) 0.3 1.6 4.2 1.3 -0.2 0.2 0.7 2.0 1.8