Hub : Genes

RCL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0980	0.0260	3.3e-05	0.067	0.053	0.039	0.053	0.050	1.4e-08	4.5e-07	1.3e-05	4.2e-07	8.8e-07
2	ROSMAP	Brain Pre-frontal Cortex	0.1097	0.0255	1.3e-07	0.056	0.073	0.073	0.074	0.071	1.1e-07	9.9e-10	1.2e-09	9.3e-10	1.9e-09
3	YFS	Blood	0.0955	0.0194	7.1e-12	0.090	0.045	0.083	0.086	0.087	8.2e-28	1.7e-14	1.2e-25	1.4e-26	4.4e-27
4	TCGA	Brain Lower Grade Glioma	0.0446	0.0218	2.0e-03	0.017	0.025	0.026	NA	0.024	4.2e-03	7.5e-04	5.3e-04	NA	8.7e-04
5	TCGA	Thyroid Carcinoma	0.0630	0.0260	2.7e-04	0.029	0.038	0.020	NA	0.020	7.9e-04	1.1e-04	4.0e-03	NA	4.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	1.2	0.5	-0.8	0.7	-1.1	0.9
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	0.7	-1.3	0.3	-1.0	-0.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.0	0.6	-0.7	-1.0	-0.7	0.4
Depression (Nagel 2018)	0.5	0.7	2.3	0.1	-1.5	0.7	-0.8	-0.2
Intelligence (Savage-Jansen 2018)	0.9	2.7	7.0	1.6	0.3	-2.6	0.5	1.8
Neuroticism (Nagel 2018)	0.2	0.5	1.5	0.0	-0.6	-0.8	-1.2	0.4
Schizophrenia (2018)	0.4	0.8	2.3	0.5	-1.1	-0.2	-0.4	-1.5
Schizophrenia vs Biploar Disorder	0.5	0.6	2.5	0.2	0.4	-1.6	0.6	-0.4
Worry (Nagel 2018)	0.3	0.6	2.0	-0.1	-0.6	-0.4	-1.4	0.4
Alzheimer’s Disease (in mother)	2.5	3.0	8.6	2.9	-0.2	-2.1	-1.3	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.6	0.0	-0.3	-0.4	-0.4
Alzheimer’s Disease (including proxy)	1.5	2.1	6.2	2.5	-0.5	-1.7	-1.1	-0.2
Crohns Disease (2017)	3.4	7.4	19.9	-4.5	1.1	3.0	2.6	-0.5
Irritable Bowel Disease (IBD)	3.5	8.2	23.4	-4.8	1.0	3.2	2.5	-0.2
Ulcerative Colitis (UC)	2.2	4.2	10.9	-3.3	0.4	2.8	1.5	-0.3
Major Depression (MDD)	1.2	1.4	2.7	0.0	1.1	-0.8	1.6	1.6
Reaction Time	0.2	0.4	1.9	-1.4	0.3	0.1	0.1	0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.8	0.5	0.7	-1.2	0.0	1.7
Breast Cancer	0.6	1.5	2.6	-1.6	1.1	0.9	0.9	1.5
Ovarian Cancer	1.3	1.7	3.6	0.0	1.2	-1.5	1.1	1.9
Prostate Cancer	4.0	5.6	9.7	2.7	-2.3	-0.7	-3.1	-2.4
Age at First Birth	0.7	1.0	1.5	-0.4	0.8	-1.1	1.2	1.2
Bipolar Disorder (2011)	0.2	0.2	0.5	0.1	-0.4	0.7	-0.3	-0.4
Body Mass Index (BMI) (2010)	0.9	1.2	3.1	-0.9	1.8	-0.0	1.4	0.2
Coronary Artery Disease (CAD)	2.7	3.2	10.4	-1.5	1.6	-0.2	3.2	0.9
Crohns Disease (2012)	3.4	5.4	15.4	-3.9	0.6	2.7	2.0	0.2
Mean Putamen Volume	1.2	1.4	2.9	0.0	-0.7	1.4	-1.7	-1.4
Fasting Glucose	0.5	0.6	1.0	-1.0	1.0	-0.4	0.5	0.7
HbA1C	0.5	0.6	1.1	0.7	1.0	-1.0	0.5	0.0
HDL Cholesterol	0.4	0.7	1.3	1.2	0.2	-1.0	0.0	0.9
LDL Cholesterol	0.3	0.5	1.1	0.4	-0.6	0.3	-1.1	-0.8
Lupus	0.9	1.3	4.0	0.6	-1.1	0.9	-0.5	-2.0
Neuroticism (2016)	0.3	0.4	1.1	1.0	-0.5	-0.7	0.2	0.3
Primary Biliary Cirrhosis	0.7	1.0	2.4	-1.6	0.6	1.0	0.4	1.1
Rheumatoid Arthritis	1.0	1.4	3.9	-0.6	0.8	0.2	1.5	2.0
Schizophrenia (2014)	0.6	1.4	1.8	1.3	-1.3	-1.0	-1.1	-1.1
Triglycerides	0.2	0.3	1.3	0.2	0.1	-0.0	-0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	0.2	1.0	-1.1	0.4	1.0
Ulcerative Colitis	2.3	3.3	9.3	-2.4	0.5	3.1	0.9	0.2
Blood Eosinophil Count	3.6	27.9	63.2	4.0	-6.4	0.4	-4.4	-8.0
Blood Platelet Count	83.5	967.8	2034.0	27.1	-36.7	-0.4	-26.9	-45.1
Blood Red Count	13.2	127.7	187.7	13.7	-12.4	-7.7	-11.3	-10.5
Blood White Count	0.6	4.2	11.0	2.3	-1.9	-0.6	-0.7	-3.3
Heel T-Score	1.7	13.4	26.9	3.1	-4.3	0.9	-5.2	-3.3
BMI	0.4	2.6	4.7	-0.1	2.2	-0.5	2.0	2.0
Height	0.2	2.9	4.8	0.8	-1.8	1.4	-2.1	-2.2
Waist Hip Ratio (WHR)	0.2	0.8	1.6	-1.3	-0.7	1.0	-0.9	0.2
Systolic Blood Pressure	0.1	0.5	1.5	0.1	-0.8	-0.5	-1.2	-0.6
Smoking Status	0.6	1.5	7.1	-0.5	0.2	-0.4	0.4	2.7
Allergy or Eczema	1.3	3.4	5.2	-2.3	1.9	-0.7	2.2	1.7
Cardiovascular Disease	0.0	0.1	0.2	0.3	0.2	-0.3	0.0	0.4
Hypothyroidism (self reported)	0.6	1.4	3.2	1.6	-1.0	-1.8	-0.1	0.3
Respiratory disease	0.2	0.5	1.7	0.2	-0.6	0.8	0.1	-1.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.8	-0.7	0.4	0.3	0.9	0.1
Lung FEV1/FVC ratio	0.4	2.0	6.0	1.7	-0.1	-2.5	-0.9	0.6
Lung FVC	0.0	0.3	0.9	-0.1	-1.0	0.1	0.2	-0.5
Neuroticism	0.2	0.5	1.1	0.6	-0.8	-0.5	-1.0	-0.3
Chronotype (morning person)	0.4	0.9	2.9	0.8	-0.8	-0.4	-1.7	-0.2
Hair Pigment	0.0	1.1	2.3	-0.3	1.0	-0.1	1.5	1.4
Tanning	0.1	0.9	2.0	1.0	0.5	-1.1	0.3	1.4
Hand grip strength (left)	0.2	0.6	1.2	-1.1	-0.6	0.7	-0.3	0.8
Number of treatments/medications taken	0.2	0.4	0.8	0.5	0.9	-0.3	0.4	-0.8
Average weekly spirits intake	0.5	0.6	1.8	-1.3	0.8	0.5	0.4	0.5
Sensitivity / hurt feelings	0.2	0.3	0.8	0.3	-0.2	-0.9	-0.7	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.4	-0.1	-0.2	0.1	0.2
Hearing difficulty/problems: Yes	1.0	1.5	2.4	1.1	0.9	-1.5	1.0	1.6
Relative age of first facial hair	0.3	0.5	0.8	-0.4	-0.8	-0.7	-0.9	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	3.3	0.5	-0.1	-0.2	-0.4	-1.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	-0.5	0.9	0.3	1.2	-0.6
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	1.0	-0.4	-0.3	-0.7	-0.1
Systolic blood pressure, automated reading	0.3	0.8	1.0	0.6	-0.9	-1.0	-0.8	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	-0.7	0.8	-0.2	1.1	0.3
Angina	0.9	1.2	3.0	-1.7	-0.1	1.7	-0.0	0.2
Medication for hormone replacement therapy	0.1	0.1	0.4	0.5	-0.1	-0.1	0.0	-0.6
Vitamin and mineral supplements	1.9	2.5	4.5	-1.4	1.4	1.0	1.8	2.1
Supplements: Zinc	0.4	0.4	1.3	0.8	-0.1	-1.1	0.6	-0.1
Medication: Co-codamol	0.3	0.3	0.7	0.7	-0.1	-0.1	-0.7	-0.8
Medication: Metformin	0.6	0.8	2.3	-0.3	1.5	-0.4	1.1	0.3
Diabetes (father)	0.3	0.4	1.1	-0.8	1.0	0.2	0.6	0.3
Diabetes (mother)	1.5	1.9	5.6	-1.7	0.7	2.4	0.9	-0.2
Severe depression (siblings)	0.3	0.3	0.6	0.8	0.8	-0.5	-0.3	0.4
Pack years adult smoking proportion	1.3	2.0	3.4	-0.8	1.7	0.2	1.7	1.9
Impedance of leg (right)	0.7	3.4	9.5	0.5	-3.1	0.5	-2.5	-0.8
Leg fat-free mass (left)	0.2	1.0	2.4	0.5	1.5	-1.1	1.0	0.6
Trunk fat percentage	0.1	0.3	0.6	-0.1	0.7	0.1	0.4	0.8
Hand grip strength (right)	0.2	0.5	1.2	-0.8	-0.8	1.1	-0.4	0.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.5	0.6	0.4	-0.3	-0.2
Current tobacco smoking	1.0	1.6	5.7	-0.4	0.8	-0.6	1.1	2.4
Average weekly fortified wine intake	0.7	0.8	2.1	0.8	-1.4	-0.7	-0.7	0.6
Maternal smoking around birth	0.8	1.2	3.5	0.0	0.6	-1.2	0.8	1.9
Fed-up feelings	0.3	0.5	1.3	0.8	-0.2	-1.1	0.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.7	0.8	-0.9	-0.8	-0.6	0.7
Relative age voice broke	0.9	1.3	2.8	0.7	-0.7	-1.3	-1.7	1.1
Taking other prescription medications	0.2	0.2	0.8	-0.0	0.5	0.0	0.3	-0.9
Age when periods started (menarche)	1.0	2.5	5.8	0.3	-2.2	0.0	-2.4	-1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-0.7	-0.1	0.8	1.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	7.5	-0.1	-2.2	2.7	-1.9	-2.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.0	1.4	-0.4	-0.8	0.3	-0.8
Qualifications: CSEs or equivalent	2.3	3.0	9.7	-0.0	1.3	-1.7	0.9	3.1
Serious illness, injury or assault to yourself	0.3	0.4	1.2	-0.6	0.4	1.1	0.3	-0.5
High blood pressure	0.0	0.1	0.4	-0.1	-0.1	0.2	0.6	-0.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.5	-1.2	0.9	-0.5	1.0	0.9
Multivitamins +/- minerals	1.0	1.2	2.6	0.9	-0.5	-1.2	-1.6	-1.0
Stomach or abdominal pain in last month	0.4	0.5	1.6	0.1	0.1	0.9	0.3	-1.3
Supplements: Glucosamine	3.1	4.0	8.7	0.4	2.3	-3.0	1.2	2.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.2	0.1	1.0	-1.1	-0.8
Medication: Atenolol	0.4	0.5	0.9	-1.0	0.7	0.8	0.5	-0.6
Medication: Levothyroxine sodium	2.2	3.7	8.1	2.8	-1.9	-2.2	-1.4	-0.4
Sitting height	0.0	0.2	0.8	0.1	0.4	-0.3	0.9	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.4	0.3	0.5	0.3	0.3
High blood pressure (mother)	0.8	1.1	2.0	0.4	1.0	-1.0	1.4	1.0
Body mass index (BMI)	0.6	2.7	5.1	0.1	2.3	-1.0	2.1	1.8
Impedance of leg (left)	0.6	2.9	8.0	0.4	-2.8	0.7	-2.3	-0.6
Leg predicted mass (left)	0.2	1.0	2.3	0.5	1.5	-1.1	1.0	0.6
Trunk fat mass	0.1	0.6	1.2	0.2	1.1	-0.5	0.7	1.0
Waist circumference	0.6	2.0	3.8	0.0	1.9	-1.0	1.3	1.9
Number of incorrect matches in round	1.8	3.0	8.3	0.5	1.3	-2.9	1.4	1.8
Past tobacco smoking	0.6	1.1	3.3	-0.4	-0.7	1.2	-0.7	-1.8
Alcohol usually taken with meals	0.6	0.9	1.8	0.7	-0.7	-1.1	-1.4	-0.7
Nervous feelings	0.8	1.4	2.4	1.4	-1.2	-1.2	-1.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	1.2	-0.4	-1.1	-0.2	0.5
Hearing difficulty/problems with background noise	0.8	1.2	2.4	1.2	0.7	-1.5	1.0	0.7
Hair/balding pattern: Pattern 2	0.8	1.0	3.3	-0.9	0.5	1.8	0.2	-0.9
Had menopause	1.1	1.3	3.0	1.6	0.3	-1.7	-0.5	-0.9
Had other major operations	0.1	0.2	0.4	-0.0	0.4	-0.5	-0.7	0.1
Forced vital capacity (FVC)	0.8	3.1	6.3	1.7	-2.5	-0.2	-2.3	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.9	-0.1	-1.5	2.6	-1.3	-1.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.7	0.8	1.6	-0.9	0.6	0.1
Qualifications: None of the above	0.7	1.5	3.6	-1.2	-0.4	1.9	0.4	-1.4
Financial difficulties in last 2 years	0.2	0.3	0.6	0.8	-0.6	-0.8	-0.0	-0.1
Mouth/teeth dental problems	0.3	0.5	1.3	1.1	-0.2	-1.0	-0.5	-0.3
Heart attack	0.3	0.4	1.2	-0.2	-0.5	0.8	-1.1	0.2
Allergy	0.1	0.2	0.6	0.8	-0.5	-0.2	-0.4	0.3
Pain all over the body in last month	1.4	1.5	3.4	1.8	-1.0	-1.4	-1.1	-0.2
Diabetes (self-reported)	1.2	1.9	5.1	-1.3	1.6	-0.3	2.3	0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	-0.9	0.9	-0.3	1.4	0.2
Medication: Ramipril	0.7	0.9	2.5	-1.6	0.2	0.8	0.2	1.1
Medication: Simvastatin	0.7	1.1	2.0	0.2	1.4	-1.2	1.3	0.6
Fluid intelligence score	0.3	0.6	2.4	-0.1	0.6	-0.2	0.1	1.6
Illnesses of siblings	0.1	0.2	0.5	-0.0	-0.7	-0.1	-0.7	0.1
Neuroticism score	0.6	1.2	2.3	1.5	-0.4	-1.5	-0.8	0.7
Weight	0.3	1.3	1.9	0.8	1.4	-1.4	0.8	1.1
Impedance of arm (right)	1.0	4.8	11.0	0.7	-3.1	1.0	-3.3	-1.4
Arm fat percentage (right)	0.3	1.3	2.7	0.0	1.3	-0.8	1.3	1.6
Trunk fat-free mass	0.3	1.9	5.0	1.3	1.4	-2.2	0.7	0.8
Hip circumference	0.5	2.3	4.0	1.3	1.4	-2.0	0.8	1.7
Time employed in main current job	1.0	1.1	3.3	-0.6	-0.8	1.0	-0.5	-1.8
Alcohol intake versus 10 years previously	2.0	3.0	7.2	-2.7	1.4	2.2	0.9	0.2
Father’s age at death	3.8	5.1	11.1	-2.5	2.4	-0.1	3.3	1.5
Worrier / anxious feelings	0.5	1.0	2.6	1.3	-0.2	-0.6	-1.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	0.7	0.0	-1.1	-0.7	-0.6
Falls in the last year	0.6	0.9	2.2	1.5	0.2	-1.2	-0.4	-0.6
Hair/balding pattern: Pattern 3	0.4	0.7	1.7	1.3	-0.1	-1.0	-0.3	0.7
Number of live births	0.1	0.2	0.7	-0.2	-0.2	-0.4	-0.2	0.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	5.9	2.0	-2.4	-0.6	-2.2	-1.4
Pulse rate	0.9	1.5	2.8	-0.3	1.7	-1.3	0.5	1.7
Happiness	0.4	0.5	1.5	-1.0	0.3	1.2	0.3	-0.0
Noisy workplace	0.1	0.1	0.4	0.3	-0.2	0.3	0.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	0.4	-0.2	-1.1	-0.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.1	-0.2	0.2	-0.2	0.5
Mouth/teeth dental problems: Dentures	0.8	1.3	3.6	-1.9	-0.1	1.7	0.2	-0.1
Asthma	0.4	0.7	2.6	0.6	-0.2	0.8	0.3	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.6	0.6	0.5	-1.6	0.6	0.6
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.4	0.3	0.3	0.9	0.8
Depression (self-reported)	0.5	0.6	2.3	1.5	-0.4	-0.5	-0.6	-0.3
Medication: Lansoprazole	0.8	0.9	2.9	-0.4	-0.0	1.7	0.6	-1.2
Prospective memory result	0.4	0.5	1.1	-1.0	0.3	1.1	-0.1	-0.4
Lung cancer (father)	0.8	1.0	3.5	-0.9	0.3	1.9	0.7	0.1
Illnesses of mother	1.1	1.3	2.7	1.2	-0.7	-1.3	-1.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.3	1.3	-2.1	-0.2	-1.2	-1.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	0.6	0.4	-1.6	0.4	-0.5
Impedance of arm (left)	1.4	6.7	14.2	0.7	-3.6	1.5	-3.8	-1.9
Arm fat mass (right)	0.4	1.5	2.4	0.3	1.5	-1.1	1.2	1.5
Trunk predicted mass	0.3	2.0	5.1	1.2	1.4	-2.2	0.8	0.8
Standing height	0.4	3.8	8.5	1.9	-2.0	-0.9	-2.9	-1.5
Length of working week for main job	0.2	0.2	0.7	0.1	-0.1	0.7	0.2	-0.8
Exposure to tobacco smoke at home	0.9	1.0	1.6	0.7	-1.3	0.8	-1.3	-0.8
Breastfed as a baby	0.5	0.6	2.0	0.5	0.7	-1.4	0.2	0.6
Tense / ‘highly strung’	0.4	0.7	2.2	0.4	0.7	-1.5	-0.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.0	1.7	-1.1	-0.9	-0.7	-1.3
Hair/balding pattern: Pattern 4	0.6	1.6	5.2	-1.0	0.8	-0.3	0.9	2.3
Birth weight of first child	0.8	1.4	2.9	-0.8	1.7	-1.2	0.9	1.1
Peak expiratory flow (PEF)	0.5	1.2	3.0	1.7	-0.7	-1.2	-0.3	-1.0
Pulse wave reflection index	0.5	0.7	2.7	-0.1	0.7	-0.4	1.6	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.3	0.2	1.5	-0.5	1.0	0.4
Loud music exposure frequency	1.0	1.1	2.5	1.1	-1.6	-0.3	-1.2	-0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.2	0.1	-0.3	-0.8	-1.1	0.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.3	-1.2	0.5	0.7	0.7	1.1
Blood clot in the leg (DVT)	1.0	1.3	2.8	1.2	-1.3	-0.3	-1.7	-0.5
Medication: Paracetamol	0.3	0.4	1.2	-0.0	-0.2	1.1	-0.3	-0.9
Headache pain in last month	0.7	1.3	2.5	-0.0	-1.6	0.7	-1.2	-1.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.4	0.5	0.2	-1.6	-0.0	0.5
Glaucoma (self-reported)	1.7	2.0	5.7	-1.0	1.2	1.5	2.4	-0.0
Gout (self-reported)	2.0	2.8	6.6	2.6	-1.4	-0.4	-1.9	-1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.2	2.0	-1.6	-1.2	-0.4	-0.2
Medication: Amlodipine	0.5	0.7	2.1	-0.2	-1.5	0.5	-0.8	-0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.5	-0.3	0.8	1.1	1.6	-0.3
Birth weight	0.2	0.4	1.6	-0.2	-0.1	-1.3	-0.3	0.7
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.3	-1.0	1.0	0.8	1.1	0.9
High blood pressure (siblings)	0.5	0.7	1.6	0.9	-0.7	0.1	-0.9	-1.3
Forced vital capacity (FVC), Best measure	0.2	0.8	2.3	0.5	-1.5	0.4	-0.7	-1.0
Body fat percentage	0.2	0.7	1.4	-0.2	1.1	-0.2	0.9	1.2
Leg fat percentage (right)	0.4	1.5	3.4	-0.2	1.3	-1.0	1.3	1.8
Arm fat-free mass (right)	0.4	1.8	3.3	0.6	1.8	-1.7	1.3	0.9
Exposure to tobacco smoke outside home	0.5	0.6	1.1	0.0	0.5	-1.1	0.9	1.0
Comparative body size at age 10	0.3	0.8	1.8	0.7	1.4	-1.1	0.6	-0.2
Number of full brothers	0.8	0.9	2.1	-1.4	0.4	1.3	0.3	-0.8
Worry too long after embarrassment	1.1	1.9	3.9	1.5	-1.0	-0.8	-1.3	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.3	0.7	-1.1	1.1	-0.5	-1.8
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.5	-0.0	0.4	0.4	0.2
Number of children fathered	0.8	0.9	2.3	1.5	-0.8	-1.1	0.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	-0.2	0.3	-0.9	0.9	0.7
Age at first live birth	0.3	0.5	1.1	-1.1	0.0	-0.6	-0.8	0.5
Pulse wave peak to peak time	0.6	0.7	2.8	-0.4	-0.6	1.7	-0.5	0.2
Health satisfaction	0.6	0.8	1.7	-0.6	1.3	0.4	1.0	0.9
Shortness of breath walking on level ground	0.1	0.1	0.4	0.1	0.6	0.2	-0.3	0.0
Qualifications: College or University degree	0.9	2.8	5.1	1.5	-2.0	-0.4	-2.3	-1.5
Eye problems/disorders: None of the above	0.3	0.4	1.1	-0.2	1.1	-0.8	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	1.4	1.6	3.4	-1.0	1.9	-0.2	1.4	1.2
Emphysema/chronic bronchitis	0.8	0.9	3.1	-0.6	-0.3	1.8	-0.3	-1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	0.6	-0.9	-0.9	-1.1	0.2
Neck or shoulder pain in last month	0.7	1.0	3.0	0.6	-0.7	-1.7	0.8	0.5
Medication: Blood pressure	1.0	1.8	2.7	0.1	-1.6	1.4	-1.5	-1.5
Angina (self-reported)	0.7	1.0	2.7	-1.6	0.2	1.4	0.3	0.3
Migraine (self-reported)	0.5	0.6	1.7	0.8	-0.1	-1.3	-0.6	-0.6
Medication: Ibuprofen	0.6	0.8	2.9	1.0	0.0	-1.7	-0.1	0.2
Medication: Allopurinol	2.4	3.2	5.9	2.4	-1.5	-0.1	-1.9	-2.1
Medication: Omeprazole	1.5	1.7	3.7	-0.9	1.4	1.9	1.3	0.5
Medication: Seretide 50 evohaler	0.9	1.0	2.2	-0.5	1.2	0.5	0.9	-1.5
Mean time to correctly identify matches	0.2	0.4	1.6	-1.3	0.6	0.2	0.3	0.2
Heart disease (mother)	0.6	0.7	1.8	0.7	-1.4	0.4	-0.2	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.9	-0.2	1.7	-0.9	1.6	1.5
Whole body fat mass	0.3	1.3	2.1	0.2	1.4	-0.9	1.2	1.4
Leg fat mass (right)	0.4	1.7	2.7	0.1	1.6	-1.0	1.5	1.6
Arm predicted mass (right)	0.3	1.8	3.1	0.7	1.7	-1.8	1.2	0.8
Pulse rate, automated reading	0.4	1.4	2.9	-1.0	1.7	-0.1	0.4	1.7
Alcohol intake frequency.	0.2	0.4	1.1	-0.5	0.0	1.1	-0.6	-0.4
Comparative height size at age 10	0.3	1.5	4.0	1.5	0.4	-2.0	-1.0	-0.1
Number of full sisters	0.1	0.2	0.3	0.6	-0.2	0.2	-0.2	-0.6
Suffer from ‘nerves’	0.5	0.8	1.9	0.7	-1.3	-0.3	-1.4	-0.1
Overall health rating	1.2	2.5	4.1	-1.7	2.0	0.8	2.0	1.1
Chest pain or discomfort	0.1	0.1	0.2	-0.0	0.3	-0.5	0.4	-0.2
Had major operations	0.6	0.7	2.1	-0.4	-0.2	1.5	-0.6	-0.9
Age at last live birth	0.7	1.0	2.5	-0.7	0.1	-1.6	-0.7	1.3
Family relationship satisfaction	0.5	0.6	1.2	-1.1	0.7	0.6	0.7	0.7
Leg pain on walking	1.8	2.3	4.6	0.6	2.1	-2.2	0.7	1.3
Qualifications: NVQ or HND or HNC or equivalent	3.7	4.5	8.0	-1.6	2.0	-1.0	2.8	2.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.9	-0.7	2.0	0.7	1.7	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	-0.3	0.4	-0.1	0.0	0.3
Medication: Aspirin	0.1	0.2	0.4	-0.2	-0.5	0.5	-0.0	-0.6
Supplements: Vitamin C	1.1	1.4	2.3	0.7	-1.4	0.1	-1.5	-1.4
Knee pain experienced in last month	1.4	2.2	4.4	1.0	2.1	-2.0	0.4	1.2
Hypertension (Self-reported)	0.1	0.2	0.3	0.5	-0.1	-0.5	0.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.3	0.7	0.1	0.7	0.8
Illnesses of father: Heart disease	1.8	2.5	5.1	2.2	1.2	-2.3	-0.8	-0.6
Illnesses of siblings: Diabetes	0.5	0.6	1.3	-0.7	1.0	0.1	1.2	0.5
Smoking status: Previous	0.3	0.5	1.1	0.8	-0.3	-0.6	0.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.6	1.3	-0.2	-0.9	0.2	0.1
Whole body fat-free mass	0.3	1.7	3.5	1.0	1.6	-1.9	1.0	0.8
Leg fat-free mass (right)	0.2	1.2	2.8	0.5	1.7	-1.1	1.1	0.8
Arm fat percentage (left)	0.3	1.0	2.0	-0.2	1.3	-0.3	1.1	1.4
Average weekly red wine intake	0.3	0.5	1.4	1.2	0.1	0.1	0.1	-0.9
Handedness (chirality/laterality): Left-handed	2.1	2.5	3.4	-1.8	1.8	1.2	1.6	1.4
Mood swings	1.0	1.8	4.7	1.0	0.1	-2.2	-0.3	1.9
Loneliness, isolation	0.3	0.4	0.6	-0.7	0.8	0.3	0.6	0.5
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-0.5	1.2	-0.2	0.9	-0.5
Ever had bowel cancer screening	1.4	1.6	4.0	-0.9	0.7	1.4	1.0	-2.0
Diabetes diagnosed by doctor	0.9	1.5	3.5	-0.5	1.6	-0.7	1.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.4	-0.2	0.1	-0.7	-0.7
Friendships satisfaction	1.8	2.3	3.9	-1.1	2.0	-0.4	1.9	1.5
Qualifications: nursing, teaching	0.3	0.4	0.8	0.6	0.6	-0.9	-0.3	0.6
Commuting to job workplace: Walk	0.2	0.3	0.7	0.3	-0.5	0.5	-0.8	0.2
Eye problems/disorders: Cataract	0.3	0.3	1.0	0.4	-1.0	0.3	-0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	0.9	-0.4	-1.0	0.4	-0.6
Medication for cholesterol	0.8	1.2	3.6	0.4	-1.9	0.5	-0.9	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	4.6	0.3	-2.1	0.6	-1.6	-1.3
Back pain experienced in last month	0.4	0.6	1.4	0.1	-0.4	1.2	0.3	-1.0
Mineral and other dietary supplements	1.8	2.4	8.6	-0.7	-1.1	2.9	-0.8	-1.1
Breast cancer (self-reported)	0.2	0.3	0.7	0.2	0.1	-0.1	-0.8	-0.8
Asthma (self-reported)	0.3	0.6	2.2	0.6	-0.4	0.6	0.0	-1.5
Osteoporosis (self-reported)	0.9	1.1	3.0	-1.1	1.7	0.7	0.8	-0.2
Osteoarthritis (self-reported)	0.4	0.5	1.5	1.2	-0.2	-0.2	-0.9	-0.0
Medication: Aspirin	0.1	0.2	0.3	-0.2	-0.6	0.4	-0.1	-0.5
Medication: Gliclazide	0.5	0.5	1.1	-1.0	0.8	-0.3	0.4	0.9
Illnesses of father: None of the above (group 1)	1.2	1.4	3.1	-0.9	-1.4	1.8	-0.5	-1.0
Smoking status: Current	0.9	1.5	4.9	-0.3	1.0	-0.8	1.0	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	-0.5	0.7	-0.9	1.3	1.0
Whole body water mass	0.3	1.7	3.2	0.8	1.7	-1.8	1.1	0.9
Leg predicted mass (right)	0.2	1.2	3.0	0.4	1.7	-1.0	1.1	0.7
Arm fat mass (left)	0.3	1.3	2.1	0.2	1.4	-0.9	1.3	1.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	0.4	0.1	-0.8	0.9	0.5
Average weekly champagne plus white wine intake	0.5	0.7	1.0	-0.9	0.8	-0.7	0.8	1.0
Miserableness	1.1	1.8	4.9	1.9	-0.7	-2.2	-0.6	0.3
Guilty feelings	0.2	0.3	0.6	0.2	0.6	0.3	0.4	0.8
Wears glasses or contact lenses	1.0	1.1	2.5	-1.6	0.7	1.2	0.3	-1.0
Ever taken oral contraceptive pill	0.7	0.8	1.8	1.3	-1.2	-0.2	0.6	-0.4
Hearing aid user	0.6	0.7	1.3	-0.9	0.9	0.6	1.1	-0.1
Mother’s age at death	1.2	1.5	3.0	-0.6	1.3	-0.6	1.4	1.7
Financial situation satisfaction	0.1	0.2	0.3	0.3	0.4	-0.2	0.5	0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	1.1	0.6	-0.9	0.5	-0.7
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.2	-0.9	-0.6	-0.4	-0.4
Eye problems/disorders: Glaucoma	1.0	1.2	3.2	-0.3	1.5	0.4	1.8	0.2
Medication: Blood pressure	0.6	1.2	2.2	0.2	1.5	-1.0	1.3	0.9
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	1.4	0.1	-1.1	-0.6	0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.2	0.9	0.2	-1.8	-0.1	-0.4
High cholesterol (Self-reported)	0.2	0.4	0.9	0.4	0.9	-0.8	0.5	0.3
Medication: Bendroflumethiazide	1.0	1.5	3.2	-0.2	1.5	-1.8	0.7	1.2
Medication: Paracetamol	0.9	1.4	3.1	0.1	-0.5	1.8	-0.7	-1.7
Medication: Lisinopril	1.4	1.8	5.3	2.3	-0.1	-1.7	-0.9	-0.2
Medication: Atorvastatin	0.3	0.3	0.8	0.4	-0.9	0.3	-0.7	0.3
Illnesses of father: High blood pressure	0.6	0.8	3.1	-0.1	0.5	-0.6	0.4	1.8
Alcohol drinker status: Never	1.1	1.3	2.1	-1.1	1.4	0.3	1.5	1.1
Ever smoked	0.5	0.8	2.7	-0.6	0.6	-0.5	0.6	1.7
Basal metabolic rate	0.3	1.6	3.0	0.9	1.5	-1.7	1.0	0.9
Leg fat percentage (left)	0.5	1.6	3.5	-0.1	1.5	-0.9	1.3	1.9
Arm fat-free mass (left)	0.3	1.6	2.9	0.8	1.7	-1.7	1.0	0.8
Number of operations (self-reported)	0.2	0.3	1.2	-0.1	-0.3	-0.3	-1.1	-0.4
Average weekly beer plus cider intake	3.1	4.5	9.1	3.0	-2.1	-2.3	-2.0	0.1
Irritability	0.6	1.0	2.7	-0.5	1.0	-1.0	0.3	1.6
Risk taking	0.3	0.5	1.6	0.2	-0.4	-0.4	0.6	1.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.7	-0.8	0.6	0.7	0.8	-0.1
Fractured/broken bones in last 5 years	1.6	2.1	3.1	-1.6	1.3	0.5	1.8	1.6
Age started oral contraceptive pill	0.3	0.4	1.6	-0.2	0.3	-0.2	-0.3	-1.2
Diastolic blood pressure, automated reading	0.3	1.0	3.6	0.9	0.7	-1.9	0.2	0.5
Ever depressed for a whole week	1.7	2.1	4.3	1.1	1.8	-2.1	1.0	1.0
Unable to work because of sickness or disability	1.1	1.4	4.5	-0.4	0.4	1.4	-0.3	-2.1
Commuting to job workplace: Cycle	2.2	2.7	6.7	1.8	-0.3	-2.6	-1.0	1.6
Myopia	1.2	1.8	4.7	-1.5	2.2	0.5	1.3	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.3	-0.0	-0.2	-0.5	-0.3
Cholesterol lowering medication	0.1	0.2	0.6	-0.1	0.8	-0.3	-0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.1	-1.1	1.8	2.0	1.3	0.6
Pain experienced in last month	0.0	0.0	0.1	0.2	0.4	-0.0	-0.0	-0.0
Supplements: Calcium	0.2	0.2	0.4	-0.6	-0.7	0.3	-0.4	-0.1
Basal cell carcinoma (self-reported)	0.9	1.0	2.1	0.8	-0.9	-1.4	-1.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.1	-0.3	0.2	-0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.1	1.1	-1.2	-0.4	-1.5	-0.1
Heart disease (siblings)	0.8	1.0	2.5	-0.5	-0.1	1.6	-0.6	-1.3
Alcohol drinker status: Previous	0.7	0.8	1.2	0.7	-0.3	1.1	-1.1	-1.0
Pack years of smoking	1.3	1.8	3.1	-0.9	1.7	0.1	1.5	1.8
Impedance of whole body	1.1	5.6	11.6	0.4	-3.4	1.6	-3.4	-1.5
Leg fat mass (left)	0.4	1.5	2.6	0.0	1.6	-0.8	1.4	1.6
Arm predicted mass (left)	0.4	1.9	3.2	0.8	1.8	-1.8	1.3	0.9