Hub : Genes

RCL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0980 0.0260 3.3e-05 0.067 0.053 0.039 0.053 0.050 1.4e-08 4.5e-07 1.3e-05 4.2e-07 8.8e-07
2 ROSMAP Brain Pre-frontal Cortex 0.1097 0.0255 1.3e-07 0.056 0.073 0.073 0.074 0.071 1.1e-07 9.9e-10 1.2e-09 9.3e-10 1.9e-09
3 YFS Blood 0.0955 0.0194 7.1e-12 0.090 0.045 0.083 0.086 0.087 8.2e-28 1.7e-14 1.2e-25 1.4e-26 4.4e-27
4 TCGA Brain Lower Grade Glioma 0.0446 0.0218 2.0e-03 0.017 0.025 0.026 NA 0.024 4.2e-03 7.5e-04 5.3e-04 NA 8.7e-04
5 TCGA Thyroid Carcinoma 0.0630 0.0260 2.7e-04 0.029 0.038 0.020 NA 0.020 7.9e-04 1.1e-04 4.0e-03 NA 4.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.7 1.2 0.5 -0.8 0.7 -1.1 0.9
Bipolar Disorder or Schizophrenia 0.3 0.7 1.7 0.7 -1.3 0.3 -1.0 -0.5
Depressed Affect (Nagel 2018) 0.2 0.5 1.0 0.6 -0.7 -1.0 -0.7 0.4
Depression (Nagel 2018) 0.5 0.7 2.3 0.1 -1.5 0.7 -0.8 -0.2
Intelligence (Savage-Jansen 2018) 0.9 2.7 7.0 1.6 0.3 -2.6 0.5 1.8
Neuroticism (Nagel 2018) 0.2 0.5 1.5 0.0 -0.6 -0.8 -1.2 0.4
Schizophrenia (2018) 0.4 0.8 2.3 0.5 -1.1 -0.2 -0.4 -1.5
Schizophrenia vs Biploar Disorder 0.5 0.6 2.5 0.2 0.4 -1.6 0.6 -0.4
Worry (Nagel 2018) 0.3 0.6 2.0 -0.1 -0.6 -0.4 -1.4 0.4
Alzheimer’s Disease (in mother) 2.5 3.0 8.6 2.9 -0.2 -2.1 -1.3 0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.4 0.6 0.0 -0.3 -0.4 -0.4
Alzheimer’s Disease (including proxy) 1.5 2.1 6.2 2.5 -0.5 -1.7 -1.1 -0.2
Crohns Disease (2017) 3.4 7.4 19.9 -4.5 1.1 3.0 2.6 -0.5
Irritable Bowel Disease (IBD) 3.5 8.2 23.4 -4.8 1.0 3.2 2.5 -0.2
Ulcerative Colitis (UC) 2.2 4.2 10.9 -3.3 0.4 2.8 1.5 -0.3
Major Depression (MDD) 1.2 1.4 2.7 0.0 1.1 -0.8 1.6 1.6
Reaction Time 0.2 0.4 1.9 -1.4 0.3 0.1 0.1 0.3
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.8 0.5 0.7 -1.2 0.0 1.7
Breast Cancer 0.6 1.5 2.6 -1.6 1.1 0.9 0.9 1.5
Ovarian Cancer 1.3 1.7 3.6 0.0 1.2 -1.5 1.1 1.9
Prostate Cancer 4.0 5.6 9.7 2.7 -2.3 -0.7 -3.1 -2.4
Age at First Birth 0.7 1.0 1.5 -0.4 0.8 -1.1 1.2 1.2
Bipolar Disorder (2011) 0.2 0.2 0.5 0.1 -0.4 0.7 -0.3 -0.4
Body Mass Index (BMI) (2010) 0.9 1.2 3.1 -0.9 1.8 -0.0 1.4 0.2
Coronary Artery Disease (CAD) 2.7 3.2 10.4 -1.5 1.6 -0.2 3.2 0.9
Crohns Disease (2012) 3.4 5.4 15.4 -3.9 0.6 2.7 2.0 0.2
Mean Putamen Volume 1.2 1.4 2.9 0.0 -0.7 1.4 -1.7 -1.4
Fasting Glucose 0.5 0.6 1.0 -1.0 1.0 -0.4 0.5 0.7
HbA1C 0.5 0.6 1.1 0.7 1.0 -1.0 0.5 0.0
HDL Cholesterol 0.4 0.7 1.3 1.2 0.2 -1.0 0.0 0.9
LDL Cholesterol 0.3 0.5 1.1 0.4 -0.6 0.3 -1.1 -0.8
Lupus 0.9 1.3 4.0 0.6 -1.1 0.9 -0.5 -2.0
Neuroticism (2016) 0.3 0.4 1.1 1.0 -0.5 -0.7 0.2 0.3
Primary Biliary Cirrhosis 0.7 1.0 2.4 -1.6 0.6 1.0 0.4 1.1
Rheumatoid Arthritis 1.0 1.4 3.9 -0.6 0.8 0.2 1.5 2.0
Schizophrenia (2014) 0.6 1.4 1.8 1.3 -1.3 -1.0 -1.1 -1.1
Triglycerides 0.2 0.3 1.3 0.2 0.1 -0.0 -0.4 -1.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.1 0.2 1.0 -1.1 0.4 1.0
Ulcerative Colitis 2.3 3.3 9.3 -2.4 0.5 3.1 0.9 0.2
Blood Eosinophil Count 3.6 27.9 63.2 4.0 -6.4 0.4 -4.4 -8.0
Blood Platelet Count 83.5 967.8 2034.0 27.1 -36.7 -0.4 -26.9 -45.1
Blood Red Count 13.2 127.7 187.7 13.7 -12.4 -7.7 -11.3 -10.5
Blood White Count 0.6 4.2 11.0 2.3 -1.9 -0.6 -0.7 -3.3
Heel T-Score 1.7 13.4 26.9 3.1 -4.3 0.9 -5.2 -3.3
BMI 0.4 2.6 4.7 -0.1 2.2 -0.5 2.0 2.0
Height 0.2 2.9 4.8 0.8 -1.8 1.4 -2.1 -2.2
Waist Hip Ratio (WHR) 0.2 0.8 1.6 -1.3 -0.7 1.0 -0.9 0.2
Systolic Blood Pressure 0.1 0.5 1.5 0.1 -0.8 -0.5 -1.2 -0.6
Smoking Status 0.6 1.5 7.1 -0.5 0.2 -0.4 0.4 2.7
Allergy or Eczema 1.3 3.4 5.2 -2.3 1.9 -0.7 2.2 1.7
Cardiovascular Disease 0.0 0.1 0.2 0.3 0.2 -0.3 0.0 0.4
Hypothyroidism (self reported) 0.6 1.4 3.2 1.6 -1.0 -1.8 -0.1 0.3
Respiratory disease 0.2 0.5 1.7 0.2 -0.6 0.8 0.1 -1.3
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.8 -0.7 0.4 0.3 0.9 0.1
Lung FEV1/FVC ratio 0.4 2.0 6.0 1.7 -0.1 -2.5 -0.9 0.6
Lung FVC 0.0 0.3 0.9 -0.1 -1.0 0.1 0.2 -0.5
Neuroticism 0.2 0.5 1.1 0.6 -0.8 -0.5 -1.0 -0.3
Chronotype (morning person) 0.4 0.9 2.9 0.8 -0.8 -0.4 -1.7 -0.2
Hair Pigment 0.0 1.1 2.3 -0.3 1.0 -0.1 1.5 1.4
Tanning 0.1 0.9 2.0 1.0 0.5 -1.1 0.3 1.4
Hand grip strength (left) 0.2 0.6 1.2 -1.1 -0.6 0.7 -0.3 0.8
Number of treatments/medications taken 0.2 0.4 0.8 0.5 0.9 -0.3 0.4 -0.8
Average weekly spirits intake 0.5 0.6 1.8 -1.3 0.8 0.5 0.4 0.5
Sensitivity / hurt feelings 0.2 0.3 0.8 0.3 -0.2 -0.9 -0.7 0.3
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.2 0.4 -0.1 -0.2 0.1 0.2
Hearing difficulty/problems: Yes 1.0 1.5 2.4 1.1 0.9 -1.5 1.0 1.6
Relative age of first facial hair 0.3 0.5 0.8 -0.4 -0.8 -0.7 -0.9 0.8
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 3.3 0.5 -0.1 -0.2 -0.4 -1.8
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.4 -0.5 0.9 0.3 1.2 -0.6
Ever had hysterectomy (womb removed) 0.3 0.3 1.0 1.0 -0.4 -0.3 -0.7 -0.1
Systolic blood pressure, automated reading 0.3 0.8 1.0 0.6 -0.9 -1.0 -0.8 -0.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.3 -0.7 0.8 -0.2 1.1 0.3
Angina 0.9 1.2 3.0 -1.7 -0.1 1.7 -0.0 0.2
Medication for hormone replacement therapy 0.1 0.1 0.4 0.5 -0.1 -0.1 0.0 -0.6
Vitamin and mineral supplements 1.9 2.5 4.5 -1.4 1.4 1.0 1.8 2.1
Supplements: Zinc 0.4 0.4 1.3 0.8 -0.1 -1.1 0.6 -0.1
Medication: Co-codamol 0.3 0.3 0.7 0.7 -0.1 -0.1 -0.7 -0.8
Medication: Metformin 0.6 0.8 2.3 -0.3 1.5 -0.4 1.1 0.3
Diabetes (father) 0.3 0.4 1.1 -0.8 1.0 0.2 0.6 0.3
Diabetes (mother) 1.5 1.9 5.6 -1.7 0.7 2.4 0.9 -0.2
Severe depression (siblings) 0.3 0.3 0.6 0.8 0.8 -0.5 -0.3 0.4
Pack years adult smoking proportion 1.3 2.0 3.4 -0.8 1.7 0.2 1.7 1.9
Impedance of leg (right) 0.7 3.4 9.5 0.5 -3.1 0.5 -2.5 -0.8
Leg fat-free mass (left) 0.2 1.0 2.4 0.5 1.5 -1.1 1.0 0.6
Trunk fat percentage 0.1 0.3 0.6 -0.1 0.7 0.1 0.4 0.8
Hand grip strength (right) 0.2 0.5 1.2 -0.8 -0.8 1.1 -0.4 0.3
Townsend deprivation index at recruitment 0.1 0.2 0.3 0.5 0.6 0.4 -0.3 -0.2
Current tobacco smoking 1.0 1.6 5.7 -0.4 0.8 -0.6 1.1 2.4
Average weekly fortified wine intake 0.7 0.8 2.1 0.8 -1.4 -0.7 -0.7 0.6
Maternal smoking around birth 0.8 1.2 3.5 0.0 0.6 -1.2 0.8 1.9
Fed-up feelings 0.3 0.5 1.3 0.8 -0.2 -1.1 0.1 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.7 0.8 -0.9 -0.8 -0.6 0.7
Relative age voice broke 0.9 1.3 2.8 0.7 -0.7 -1.3 -1.7 1.1
Taking other prescription medications 0.2 0.2 0.8 -0.0 0.5 0.0 0.3 -0.9
Age when periods started (menarche) 1.0 2.5 5.8 0.3 -2.2 0.0 -2.4 -1.3
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 -0.7 -0.1 0.8 1.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.1 7.5 -0.1 -2.2 2.7 -1.9 -2.2
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.0 1.4 -0.4 -0.8 0.3 -0.8
Qualifications: CSEs or equivalent 2.3 3.0 9.7 -0.0 1.3 -1.7 0.9 3.1
Serious illness, injury or assault to yourself 0.3 0.4 1.2 -0.6 0.4 1.1 0.3 -0.5
High blood pressure 0.0 0.1 0.4 -0.1 -0.1 0.2 0.6 -0.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.5 -1.2 0.9 -0.5 1.0 0.9
Multivitamins +/- minerals 1.0 1.2 2.6 0.9 -0.5 -1.2 -1.6 -1.0
Stomach or abdominal pain in last month 0.4 0.5 1.6 0.1 0.1 0.9 0.3 -1.3
Supplements: Glucosamine 3.1 4.0 8.7 0.4 2.3 -3.0 1.2 2.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 -0.2 0.1 1.0 -1.1 -0.8
Medication: Atenolol 0.4 0.5 0.9 -1.0 0.7 0.8 0.5 -0.6
Medication: Levothyroxine sodium 2.2 3.7 8.1 2.8 -1.9 -2.2 -1.4 -0.4
Sitting height 0.0 0.2 0.8 0.1 0.4 -0.3 0.9 0.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.4 0.3 0.5 0.3 0.3
High blood pressure (mother) 0.8 1.1 2.0 0.4 1.0 -1.0 1.4 1.0
Body mass index (BMI) 0.6 2.7 5.1 0.1 2.3 -1.0 2.1 1.8
Impedance of leg (left) 0.6 2.9 8.0 0.4 -2.8 0.7 -2.3 -0.6
Leg predicted mass (left) 0.2 1.0 2.3 0.5 1.5 -1.1 1.0 0.6
Trunk fat mass 0.1 0.6 1.2 0.2 1.1 -0.5 0.7 1.0
Waist circumference 0.6 2.0 3.8 0.0 1.9 -1.0 1.3 1.9
Number of incorrect matches in round 1.8 3.0 8.3 0.5 1.3 -2.9 1.4 1.8
Past tobacco smoking 0.6 1.1 3.3 -0.4 -0.7 1.2 -0.7 -1.8
Alcohol usually taken with meals 0.6 0.9 1.8 0.7 -0.7 -1.1 -1.4 -0.7
Nervous feelings 0.8 1.4 2.4 1.4 -1.2 -1.2 -1.5 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.4 1.2 -0.4 -1.1 -0.2 0.5
Hearing difficulty/problems with background noise 0.8 1.2 2.4 1.2 0.7 -1.5 1.0 0.7
Hair/balding pattern: Pattern 2 0.8 1.0 3.3 -0.9 0.5 1.8 0.2 -0.9
Had menopause 1.1 1.3 3.0 1.6 0.3 -1.7 -0.5 -0.9
Had other major operations 0.1 0.2 0.4 -0.0 0.4 -0.5 -0.7 0.1
Forced vital capacity (FVC) 0.8 3.1 6.3 1.7 -2.5 -0.2 -2.3 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 6.9 -0.1 -1.5 2.6 -1.3 -1.8
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.7 0.8 1.6 -0.9 0.6 0.1
Qualifications: None of the above 0.7 1.5 3.6 -1.2 -0.4 1.9 0.4 -1.4
Financial difficulties in last 2 years 0.2 0.3 0.6 0.8 -0.6 -0.8 -0.0 -0.1
Mouth/teeth dental problems 0.3 0.5 1.3 1.1 -0.2 -1.0 -0.5 -0.3
Heart attack 0.3 0.4 1.2 -0.2 -0.5 0.8 -1.1 0.2
Allergy 0.1 0.2 0.6 0.8 -0.5 -0.2 -0.4 0.3
Pain all over the body in last month 1.4 1.5 3.4 1.8 -1.0 -1.4 -1.1 -0.2
Diabetes (self-reported) 1.2 1.9 5.1 -1.3 1.6 -0.3 2.3 0.2
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.0 -0.9 0.9 -0.3 1.4 0.2
Medication: Ramipril 0.7 0.9 2.5 -1.6 0.2 0.8 0.2 1.1
Medication: Simvastatin 0.7 1.1 2.0 0.2 1.4 -1.2 1.3 0.6
Fluid intelligence score 0.3 0.6 2.4 -0.1 0.6 -0.2 0.1 1.6
Illnesses of siblings 0.1 0.2 0.5 -0.0 -0.7 -0.1 -0.7 0.1
Neuroticism score 0.6 1.2 2.3 1.5 -0.4 -1.5 -0.8 0.7
Weight 0.3 1.3 1.9 0.8 1.4 -1.4 0.8 1.1
Impedance of arm (right) 1.0 4.8 11.0 0.7 -3.1 1.0 -3.3 -1.4
Arm fat percentage (right) 0.3 1.3 2.7 0.0 1.3 -0.8 1.3 1.6
Trunk fat-free mass 0.3 1.9 5.0 1.3 1.4 -2.2 0.7 0.8
Hip circumference 0.5 2.3 4.0 1.3 1.4 -2.0 0.8 1.7
Time employed in main current job 1.0 1.1 3.3 -0.6 -0.8 1.0 -0.5 -1.8
Alcohol intake versus 10 years previously 2.0 3.0 7.2 -2.7 1.4 2.2 0.9 0.2
Father’s age at death 3.8 5.1 11.1 -2.5 2.4 -0.1 3.3 1.5
Worrier / anxious feelings 0.5 1.0 2.6 1.3 -0.2 -0.6 -1.6 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.1 0.7 0.0 -1.1 -0.7 -0.6
Falls in the last year 0.6 0.9 2.2 1.5 0.2 -1.2 -0.4 -0.6
Hair/balding pattern: Pattern 3 0.4 0.7 1.7 1.3 -0.1 -1.0 -0.3 0.7
Number of live births 0.1 0.2 0.7 -0.2 -0.2 -0.4 -0.2 0.8
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 5.9 2.0 -2.4 -0.6 -2.2 -1.4
Pulse rate 0.9 1.5 2.8 -0.3 1.7 -1.3 0.5 1.7
Happiness 0.4 0.5 1.5 -1.0 0.3 1.2 0.3 -0.0
Noisy workplace 0.1 0.1 0.4 0.3 -0.2 0.3 0.1 -0.6
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.2 0.4 -0.2 -1.1 -0.4 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.1 -0.2 0.2 -0.2 0.5
Mouth/teeth dental problems: Dentures 0.8 1.3 3.6 -1.9 -0.1 1.7 0.2 -0.1
Asthma 0.4 0.7 2.6 0.6 -0.2 0.8 0.3 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.6 0.6 0.5 -1.6 0.6 0.6
Medication: Cholesterol lowering 0.2 0.3 0.8 -0.4 0.3 0.3 0.9 0.8
Depression (self-reported) 0.5 0.6 2.3 1.5 -0.4 -0.5 -0.6 -0.3
Medication: Lansoprazole 0.8 0.9 2.9 -0.4 -0.0 1.7 0.6 -1.2
Prospective memory result 0.4 0.5 1.1 -1.0 0.3 1.1 -0.1 -0.4
Lung cancer (father) 0.8 1.0 3.5 -0.9 0.3 1.9 0.7 0.1
Illnesses of mother 1.1 1.3 2.7 1.2 -0.7 -1.3 -1.6 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 4.3 1.3 -2.1 -0.2 -1.2 -1.2
Pulse wave Arterial Stiffness index 0.6 0.7 2.5 0.6 0.4 -1.6 0.4 -0.5
Impedance of arm (left) 1.4 6.7 14.2 0.7 -3.6 1.5 -3.8 -1.9
Arm fat mass (right) 0.4 1.5 2.4 0.3 1.5 -1.1 1.2 1.5
Trunk predicted mass 0.3 2.0 5.1 1.2 1.4 -2.2 0.8 0.8
Standing height 0.4 3.8 8.5 1.9 -2.0 -0.9 -2.9 -1.5
Length of working week for main job 0.2 0.2 0.7 0.1 -0.1 0.7 0.2 -0.8
Exposure to tobacco smoke at home 0.9 1.0 1.6 0.7 -1.3 0.8 -1.3 -0.8
Breastfed as a baby 0.5 0.6 2.0 0.5 0.7 -1.4 0.2 0.6
Tense / ‘highly strung’ 0.4 0.7 2.2 0.4 0.7 -1.5 -0.0 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.0 1.7 -1.1 -0.9 -0.7 -1.3
Hair/balding pattern: Pattern 4 0.6 1.6 5.2 -1.0 0.8 -0.3 0.9 2.3
Birth weight of first child 0.8 1.4 2.9 -0.8 1.7 -1.2 0.9 1.1
Peak expiratory flow (PEF) 0.5 1.2 3.0 1.7 -0.7 -1.2 -0.3 -1.0
Pulse wave reflection index 0.5 0.7 2.7 -0.1 0.7 -0.4 1.6 -0.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.3 0.2 1.5 -0.5 1.0 0.4
Loud music exposure frequency 1.0 1.1 2.5 1.1 -1.6 -0.3 -1.2 -0.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.2 0.1 -0.3 -0.8 -1.1 0.0
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.3 -1.2 0.5 0.7 0.7 1.1
Blood clot in the leg (DVT) 1.0 1.3 2.8 1.2 -1.3 -0.3 -1.7 -0.5
Medication: Paracetamol 0.3 0.4 1.2 -0.0 -0.2 1.1 -0.3 -0.9
Headache pain in last month 0.7 1.3 2.5 -0.0 -1.6 0.7 -1.2 -1.4
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.4 0.5 0.2 -1.6 -0.0 0.5
Glaucoma (self-reported) 1.7 2.0 5.7 -1.0 1.2 1.5 2.4 -0.0
Gout (self-reported) 2.0 2.8 6.6 2.6 -1.4 -0.4 -1.9 -1.2
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 4.2 2.0 -1.6 -1.2 -0.4 -0.2
Medication: Amlodipine 0.5 0.7 2.1 -0.2 -1.5 0.5 -0.8 -0.5
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.5 -0.3 0.8 1.1 1.6 -0.3
Birth weight 0.2 0.4 1.6 -0.2 -0.1 -1.3 -0.3 0.7
Chronic bronchitis/emphysema (mother) 0.9 1.0 1.3 -1.0 1.0 0.8 1.1 0.9
High blood pressure (siblings) 0.5 0.7 1.6 0.9 -0.7 0.1 -0.9 -1.3
Forced vital capacity (FVC), Best measure 0.2 0.8 2.3 0.5 -1.5 0.4 -0.7 -1.0
Body fat percentage 0.2 0.7 1.4 -0.2 1.1 -0.2 0.9 1.2
Leg fat percentage (right) 0.4 1.5 3.4 -0.2 1.3 -1.0 1.3 1.8
Arm fat-free mass (right) 0.4 1.8 3.3 0.6 1.8 -1.7 1.3 0.9
Exposure to tobacco smoke outside home 0.5 0.6 1.1 0.0 0.5 -1.1 0.9 1.0
Comparative body size at age 10 0.3 0.8 1.8 0.7 1.4 -1.1 0.6 -0.2
Number of full brothers 0.8 0.9 2.1 -1.4 0.4 1.3 0.3 -0.8
Worry too long after embarrassment 1.1 1.9 3.9 1.5 -1.0 -0.8 -1.3 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.3 0.7 -1.1 1.1 -0.5 -1.8
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 0.5 -0.0 0.4 0.4 0.2
Number of children fathered 0.8 0.9 2.3 1.5 -0.8 -1.1 0.0 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.8 -0.2 0.3 -0.9 0.9 0.7
Age at first live birth 0.3 0.5 1.1 -1.1 0.0 -0.6 -0.8 0.5
Pulse wave peak to peak time 0.6 0.7 2.8 -0.4 -0.6 1.7 -0.5 0.2
Health satisfaction 0.6 0.8 1.7 -0.6 1.3 0.4 1.0 0.9
Shortness of breath walking on level ground 0.1 0.1 0.4 0.1 0.6 0.2 -0.3 0.0
Qualifications: College or University degree 0.9 2.8 5.1 1.5 -2.0 -0.4 -2.3 -1.5
Eye problems/disorders: None of the above 0.3 0.4 1.1 -0.2 1.1 -0.8 0.2 -0.2
Mouth/teeth dental problems: Loose teeth 1.4 1.6 3.4 -1.0 1.9 -0.2 1.4 1.2
Emphysema/chronic bronchitis 0.8 0.9 3.1 -0.6 -0.3 1.8 -0.3 -1.0
Medication for pain relief, constipation, heartburn 0.4 0.7 1.3 0.6 -0.9 -0.9 -1.1 0.2
Neck or shoulder pain in last month 0.7 1.0 3.0 0.6 -0.7 -1.7 0.8 0.5
Medication: Blood pressure 1.0 1.8 2.7 0.1 -1.6 1.4 -1.5 -1.5
Angina (self-reported) 0.7 1.0 2.7 -1.6 0.2 1.4 0.3 0.3
Migraine (self-reported) 0.5 0.6 1.7 0.8 -0.1 -1.3 -0.6 -0.6
Medication: Ibuprofen 0.6 0.8 2.9 1.0 0.0 -1.7 -0.1 0.2
Medication: Allopurinol 2.4 3.2 5.9 2.4 -1.5 -0.1 -1.9 -2.1
Medication: Omeprazole 1.5 1.7 3.7 -0.9 1.4 1.9 1.3 0.5
Medication: Seretide 50 evohaler 0.9 1.0 2.2 -0.5 1.2 0.5 0.9 -1.5
Mean time to correctly identify matches 0.2 0.4 1.6 -1.3 0.6 0.2 0.3 0.2
Heart disease (mother) 0.6 0.7 1.8 0.7 -1.4 0.4 -0.2 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 2.9 -0.2 1.7 -0.9 1.6 1.5
Whole body fat mass 0.3 1.3 2.1 0.2 1.4 -0.9 1.2 1.4
Leg fat mass (right) 0.4 1.7 2.7 0.1 1.6 -1.0 1.5 1.6
Arm predicted mass (right) 0.3 1.8 3.1 0.7 1.7 -1.8 1.2 0.8
Pulse rate, automated reading 0.4 1.4 2.9 -1.0 1.7 -0.1 0.4 1.7
Alcohol intake frequency. 0.2 0.4 1.1 -0.5 0.0 1.1 -0.6 -0.4
Comparative height size at age 10 0.3 1.5 4.0 1.5 0.4 -2.0 -1.0 -0.1
Number of full sisters 0.1 0.2 0.3 0.6 -0.2 0.2 -0.2 -0.6
Suffer from ‘nerves’ 0.5 0.8 1.9 0.7 -1.3 -0.3 -1.4 -0.1
Overall health rating 1.2 2.5 4.1 -1.7 2.0 0.8 2.0 1.1
Chest pain or discomfort 0.1 0.1 0.2 -0.0 0.3 -0.5 0.4 -0.2
Had major operations 0.6 0.7 2.1 -0.4 -0.2 1.5 -0.6 -0.9
Age at last live birth 0.7 1.0 2.5 -0.7 0.1 -1.6 -0.7 1.3
Family relationship satisfaction 0.5 0.6 1.2 -1.1 0.7 0.6 0.7 0.7
Leg pain on walking 1.8 2.3 4.6 0.6 2.1 -2.2 0.7 1.3
Qualifications: NVQ or HND or HNC or equivalent 3.7 4.5 8.0 -1.6 2.0 -1.0 2.8 2.6
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.9 -0.7 2.0 0.7 1.7 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 -0.3 0.4 -0.1 0.0 0.3
Medication: Aspirin 0.1 0.2 0.4 -0.2 -0.5 0.5 -0.0 -0.6
Supplements: Vitamin C 1.1 1.4 2.3 0.7 -1.4 0.1 -1.5 -1.4
Knee pain experienced in last month 1.4 2.2 4.4 1.0 2.1 -2.0 0.4 1.2
Hypertension (Self-reported) 0.1 0.2 0.3 0.5 -0.1 -0.5 0.6 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 -0.3 0.7 0.1 0.7 0.8
Illnesses of father: Heart disease 1.8 2.5 5.1 2.2 1.2 -2.3 -0.8 -0.6
Illnesses of siblings: Diabetes 0.5 0.6 1.3 -0.7 1.0 0.1 1.2 0.5
Smoking status: Previous 0.3 0.5 1.1 0.8 -0.3 -0.6 0.1 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.6 1.3 -0.2 -0.9 0.2 0.1
Whole body fat-free mass 0.3 1.7 3.5 1.0 1.6 -1.9 1.0 0.8
Leg fat-free mass (right) 0.2 1.2 2.8 0.5 1.7 -1.1 1.1 0.8
Arm fat percentage (left) 0.3 1.0 2.0 -0.2 1.3 -0.3 1.1 1.4
Average weekly red wine intake 0.3 0.5 1.4 1.2 0.1 0.1 0.1 -0.9
Handedness (chirality/laterality): Left-handed 2.1 2.5 3.4 -1.8 1.8 1.2 1.6 1.4
Mood swings 1.0 1.8 4.7 1.0 0.1 -2.2 -0.3 1.9
Loneliness, isolation 0.3 0.4 0.6 -0.7 0.8 0.3 0.6 0.5
Long-standing illness, disability or infirmity 0.4 0.6 1.5 -0.5 1.2 -0.2 0.9 -0.5
Ever had bowel cancer screening 1.4 1.6 4.0 -0.9 0.7 1.4 1.0 -2.0
Diabetes diagnosed by doctor 0.9 1.5 3.5 -0.5 1.6 -0.7 1.9 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 0.4 -0.2 0.1 -0.7 -0.7
Friendships satisfaction 1.8 2.3 3.9 -1.1 2.0 -0.4 1.9 1.5
Qualifications: nursing, teaching 0.3 0.4 0.8 0.6 0.6 -0.9 -0.3 0.6
Commuting to job workplace: Walk 0.2 0.3 0.7 0.3 -0.5 0.5 -0.8 0.2
Eye problems/disorders: Cataract 0.3 0.3 1.0 0.4 -1.0 0.3 -0.2 0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.0 0.9 -0.4 -1.0 0.4 -0.6
Medication for cholesterol 0.8 1.2 3.6 0.4 -1.9 0.5 -0.9 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.8 4.6 0.3 -2.1 0.6 -1.6 -1.3
Back pain experienced in last month 0.4 0.6 1.4 0.1 -0.4 1.2 0.3 -1.0
Mineral and other dietary supplements 1.8 2.4 8.6 -0.7 -1.1 2.9 -0.8 -1.1
Breast cancer (self-reported) 0.2 0.3 0.7 0.2 0.1 -0.1 -0.8 -0.8
Asthma (self-reported) 0.3 0.6 2.2 0.6 -0.4 0.6 0.0 -1.5
Osteoporosis (self-reported) 0.9 1.1 3.0 -1.1 1.7 0.7 0.8 -0.2
Osteoarthritis (self-reported) 0.4 0.5 1.5 1.2 -0.2 -0.2 -0.9 -0.0
Medication: Aspirin 0.1 0.2 0.3 -0.2 -0.6 0.4 -0.1 -0.5
Medication: Gliclazide 0.5 0.5 1.1 -1.0 0.8 -0.3 0.4 0.9
Illnesses of father: None of the above (group 1) 1.2 1.4 3.1 -0.9 -1.4 1.8 -0.5 -1.0
Smoking status: Current 0.9 1.5 4.9 -0.3 1.0 -0.8 1.0 2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.7 -0.5 0.7 -0.9 1.3 1.0
Whole body water mass 0.3 1.7 3.2 0.8 1.7 -1.8 1.1 0.9
Leg predicted mass (right) 0.2 1.2 3.0 0.4 1.7 -1.0 1.1 0.7
Arm fat mass (left) 0.3 1.3 2.1 0.2 1.4 -0.9 1.3 1.4
Number of self-reported non-cancer illnesses 0.2 0.4 0.8 0.4 0.1 -0.8 0.9 0.5
Average weekly champagne plus white wine intake 0.5 0.7 1.0 -0.9 0.8 -0.7 0.8 1.0
Miserableness 1.1 1.8 4.9 1.9 -0.7 -2.2 -0.6 0.3
Guilty feelings 0.2 0.3 0.6 0.2 0.6 0.3 0.4 0.8
Wears glasses or contact lenses 1.0 1.1 2.5 -1.6 0.7 1.2 0.3 -1.0
Ever taken oral contraceptive pill 0.7 0.8 1.8 1.3 -1.2 -0.2 0.6 -0.4
Hearing aid user 0.6 0.7 1.3 -0.9 0.9 0.6 1.1 -0.1
Mother’s age at death 1.2 1.5 3.0 -0.6 1.3 -0.6 1.4 1.7
Financial situation satisfaction 0.1 0.2 0.3 0.3 0.4 -0.2 0.5 0.5
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 1.1 0.6 -0.9 0.5 -0.7
Commuting to job workplace: Public transport 0.3 0.3 0.8 -0.2 -0.9 -0.6 -0.4 -0.4
Eye problems/disorders: Glaucoma 1.0 1.2 3.2 -0.3 1.5 0.4 1.8 0.2
Medication: Blood pressure 0.6 1.2 2.2 0.2 1.5 -1.0 1.3 0.9
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.9 1.4 0.1 -1.1 -0.6 0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.2 0.9 0.2 -1.8 -0.1 -0.4
High cholesterol (Self-reported) 0.2 0.4 0.9 0.4 0.9 -0.8 0.5 0.3
Medication: Bendroflumethiazide 1.0 1.5 3.2 -0.2 1.5 -1.8 0.7 1.2
Medication: Paracetamol 0.9 1.4 3.1 0.1 -0.5 1.8 -0.7 -1.7
Medication: Lisinopril 1.4 1.8 5.3 2.3 -0.1 -1.7 -0.9 -0.2
Medication: Atorvastatin 0.3 0.3 0.8 0.4 -0.9 0.3 -0.7 0.3
Illnesses of father: High blood pressure 0.6 0.8 3.1 -0.1 0.5 -0.6 0.4 1.8
Alcohol drinker status: Never 1.1 1.3 2.1 -1.1 1.4 0.3 1.5 1.1
Ever smoked 0.5 0.8 2.7 -0.6 0.6 -0.5 0.6 1.7
Basal metabolic rate 0.3 1.6 3.0 0.9 1.5 -1.7 1.0 0.9
Leg fat percentage (left) 0.5 1.6 3.5 -0.1 1.5 -0.9 1.3 1.9
Arm fat-free mass (left) 0.3 1.6 2.9 0.8 1.7 -1.7 1.0 0.8
Number of operations (self-reported) 0.2 0.3 1.2 -0.1 -0.3 -0.3 -1.1 -0.4
Average weekly beer plus cider intake 3.1 4.5 9.1 3.0 -2.1 -2.3 -2.0 0.1
Irritability 0.6 1.0 2.7 -0.5 1.0 -1.0 0.3 1.6
Risk taking 0.3 0.5 1.6 0.2 -0.4 -0.4 0.6 1.3
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.7 -0.8 0.6 0.7 0.8 -0.1
Fractured/broken bones in last 5 years 1.6 2.1 3.1 -1.6 1.3 0.5 1.8 1.6
Age started oral contraceptive pill 0.3 0.4 1.6 -0.2 0.3 -0.2 -0.3 -1.2
Diastolic blood pressure, automated reading 0.3 1.0 3.6 0.9 0.7 -1.9 0.2 0.5
Ever depressed for a whole week 1.7 2.1 4.3 1.1 1.8 -2.1 1.0 1.0
Unable to work because of sickness or disability 1.1 1.4 4.5 -0.4 0.4 1.4 -0.3 -2.1
Commuting to job workplace: Cycle 2.2 2.7 6.7 1.8 -0.3 -2.6 -1.0 1.6
Myopia 1.2 1.8 4.7 -1.5 2.2 0.5 1.3 0.2
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.3 0.3 -0.0 -0.2 -0.5 -0.3
Cholesterol lowering medication 0.1 0.2 0.6 -0.1 0.8 -0.3 -0.1 0.1
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 4.1 -1.1 1.8 2.0 1.3 0.6
Pain experienced in last month 0.0 0.0 0.1 0.2 0.4 -0.0 -0.0 -0.0
Supplements: Calcium 0.2 0.2 0.4 -0.6 -0.7 0.3 -0.4 -0.1
Basal cell carcinoma (self-reported) 0.9 1.0 2.1 0.8 -0.9 -1.4 -1.2 -0.1
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.6 0.1 -0.3 0.2 -0.8 0.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.1 1.1 -1.2 -0.4 -1.5 -0.1
Heart disease (siblings) 0.8 1.0 2.5 -0.5 -0.1 1.6 -0.6 -1.3
Alcohol drinker status: Previous 0.7 0.8 1.2 0.7 -0.3 1.1 -1.1 -1.0
Pack years of smoking 1.3 1.8 3.1 -0.9 1.7 0.1 1.5 1.8
Impedance of whole body 1.1 5.6 11.6 0.4 -3.4 1.6 -3.4 -1.5
Leg fat mass (left) 0.4 1.5 2.6 0.0 1.6 -0.8 1.4 1.6
Arm predicted mass (left) 0.4 1.9 3.2 0.8 1.8 -1.8 1.3 0.9