Hub : Genes

CDC37L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.1356 0.0323 0.00001 0.079 NA 0.082 NA 0.078 3.6e-08 NA 1.7e-08 NA 4.1e-08
2 ROSMAP Brain Pre-frontal Cortex 0.0947 0.0272 0.00013 0.072 0.045 0.076 0.068 0.085 1.5e-09 1.6e-06 4.7e-10 4.4e-09 4.6e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.4 2.2 2.5 1.4 -1.6
Bipolar Disorder or Schizophrenia 1.5 3.7 3.9 1.9 -2.0
Depressed Affect (Nagel 2018) 0.7 1.5 1.6 1.3 -1.2
Depression (Nagel 2018) 4.9 7.4 7.9 2.6 -2.8
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.2 0.5 0.4
Neuroticism (Nagel 2018) 0.6 1.4 1.6 1.3 -1.1
Schizophrenia (2018) 0.8 1.6 1.6 1.3 -1.3
Schizophrenia vs Biploar Disorder 0.7 0.9 1.3 -1.1 0.7
Worry (Nagel 2018) 0.5 1.1 1.1 1.0 -1.1
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 0.4 -0.5
Alzheimer’s Disease (in father) 0.6 0.7 0.9 1.0 -0.7
Alzheimer’s Disease (including proxy) 0.9 1.3 1.7 1.3 -1.0
Crohns Disease (2017) 0.2 0.5 1.0 -0.2 1.0
Irritable Bowel Disease (IBD) 0.5 1.2 1.9 1.4 -0.8
Ulcerative Colitis (UC) 2.0 3.7 4.5 2.1 -1.7
Major Depression (MDD) 0.2 0.2 0.4 -0.6 0.0
Reaction Time 4.8 9.2 9.9 2.9 -3.1
Verbal and Numeric Reasoning (VNR) 0.0 0.0 0.1 0.3 0.1
Breast Cancer 2.3 5.6 7.0 -2.1 2.6
Ovarian Cancer 0.2 0.3 0.4 0.4 -0.6
Prostate Cancer 0.1 0.1 0.1 -0.4 0.1
Age at First Birth 0.3 0.4 0.4 0.6 -0.6
Bipolar Disorder (2011) 2.8 2.7 3.0 1.6 -1.7
Body Mass Index (BMI) (2010) 6.7 9.2 9.5 3.0 -3.1
Coronary Artery Disease (CAD) 0.5 0.6 1.0 0.4 1.0
Crohns Disease (2012) 0.1 0.1 0.2 0.5 0.0
Mean Putamen Volume 2.5 2.9 3.8 1.9 -1.4
Fasting Glucose 0.4 0.5 0.8 0.5 -0.9
HbA1C 0.8 0.8 1.1 -0.8 1.0
HDL Cholesterol 1.5 2.5 2.7 -1.5 1.6
LDL Cholesterol 0.1 0.2 0.2 0.4 -0.4
Lupus 0.4 0.6 0.9 1.0 -0.5
Neuroticism (2016) 0.1 0.1 0.2 -0.1 0.5
Primary Biliary Cirrhosis 1.3 1.9 2.2 1.3 -1.5
Rheumatoid Arthritis 0.8 1.1 1.5 -0.9 1.2
Schizophrenia (2014) 0.9 2.0 2.6 1.2 -1.6
Triglycerides 0.0 0.1 0.1 -0.2 -0.3
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.4 -0.6 -0.2
Ulcerative Colitis 2.8 4.1 4.9 2.2 -1.8
Blood Eosinophil Count 0.3 2.5 4.3 2.1 -0.9
Blood Platelet Count 0.2 2.3 2.8 1.4 1.7
Blood Red Count 5.5 53.0 59.8 6.8 -7.7
Blood White Count 1.0 7.5 9.2 3.0 -2.4
Heel T-Score 1.2 9.8 10.4 3.2 -3.0
BMI 0.1 0.7 1.0 0.6 -1.0
Height 0.4 8.6 10.5 2.6 -3.2
Waist Hip Ratio (WHR) 1.5 6.5 8.3 2.2 -2.9
Systolic Blood Pressure 0.6 3.2 3.2 1.8 -1.8
Smoking Status 0.5 1.1 1.2 1.0 -1.1
Allergy or Eczema 0.3 0.9 1.2 0.8 -1.1
Cardiovascular Disease 0.7 2.3 2.3 1.5 -1.5
Hypothyroidism (self reported) 0.0 0.0 0.0 0.2 0.1
Respiratory disease 0.0 0.0 0.0 -0.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.5 0.7 -0.3
Lung FEV1/FVC ratio 0.1 0.3 0.5 0.7 -0.0
Lung FVC 0.5 2.5 3.0 1.7 -1.4
Neuroticism 0.8 1.9 2.0 1.4 -1.3
Chronotype (morning person) 1.4 3.3 3.9 -1.7 2.0
Hair Pigment 0.1 2.7 3.6 1.3 -1.9
Tanning 0.0 0.0 0.0 0.1 -0.2
Hand grip strength (left) 1.9 5.0 5.7 -2.0 2.4
Number of treatments/medications taken 0.3 0.6 0.6 0.7 -0.8
Average weekly spirits intake 0.0 0.0 0.0 0.0 0.1
Sensitivity / hurt feelings 0.0 0.1 0.1 0.3 0.0
Frequency of depressed mood in last 2 weeks 1.0 1.4 1.7 1.1 -1.3
Hearing difficulty/problems: Yes 0.2 0.4 0.5 0.7 -0.5
Relative age of first facial hair 0.3 0.6 0.8 0.9 -0.7
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.0 0.2 -1.0
Ever used hormone-replacement therapy (HRT) 2.8 3.6 4.0 -2.0 1.8
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 0.2 -0.1
Systolic blood pressure, automated reading 0.2 0.7 0.7 0.8 -0.9
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.4 0.1
Angina 0.3 0.3 0.4 -0.6 0.6
Medication for hormone replacement therapy 0.3 0.3 0.4 0.5 -0.6
Vitamin and mineral supplements 0.3 0.4 0.6 0.8 -0.4
Supplements: Zinc 0.7 0.7 1.1 0.6 -1.0
Medication: Co-codamol 3.0 3.5 4.2 1.7 -2.0
Medication: Metformin 0.6 0.8 1.1 0.7 -1.0
Diabetes (father) 0.1 0.2 0.3 0.2 -0.5
Diabetes (mother) 1.1 1.4 1.9 1.4 -1.0
Severe depression (siblings) 0.1 0.1 0.2 0.4 -0.4
Pack years adult smoking proportion 0.5 0.7 1.1 1.1 -0.6
Impedance of leg (right) 0.0 0.2 0.4 -0.2 0.6
Leg fat-free mass (left) 0.7 3.5 4.3 1.7 -2.1
Trunk fat percentage 0.0 0.0 0.1 0.1 0.3
Hand grip strength (right) 1.6 4.3 4.8 -2.0 2.2
Townsend deprivation index at recruitment 1.9 2.7 3.1 -1.5 1.8
Current tobacco smoking 0.7 1.1 1.6 1.3 -0.8
Average weekly fortified wine intake 1.4 1.6 2.1 -1.1 1.4
Maternal smoking around birth 0.1 0.1 0.1 0.2 0.4
Fed-up feelings 0.3 0.6 0.7 0.9 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.6 1.0 -1.2
Relative age voice broke 0.0 0.1 0.1 0.2 0.3
Taking other prescription medications 0.3 0.5 0.6 0.6 -0.8
Age when periods started (menarche) 0.1 0.3 0.5 -0.3 -0.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.2 0.4 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 3.5 8.0 9.1 3.0 -2.6
Tinnitus: Yes, but not now, but have in the past 1.5 1.7 1.9 -1.4 1.2
Qualifications: CSEs or equivalent 0.8 1.0 1.1 -0.9 1.1
Serious illness, injury or assault to yourself 0.7 0.8 0.9 0.8 -1.0
High blood pressure 0.9 2.6 3.7 1.9 -1.2
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.3 0.7 -1.2
Multivitamins +/- minerals 0.3 0.4 0.7 0.3 -0.9
Stomach or abdominal pain in last month 0.1 0.1 0.1 0.2 0.3
Supplements: Glucosamine 0.0 0.0 0.0 -0.0 -0.1
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 -0.0 0.0
Medication: Atenolol 0.2 0.2 0.3 0.5 -0.5
Medication: Levothyroxine sodium 0.1 0.2 0.4 0.1 0.6
Sitting height 0.2 1.4 2.0 0.8 -1.4
Chronic bronchitis/emphysema (father) 0.2 0.2 0.3 -0.2 0.6
High blood pressure (mother) 0.1 0.1 0.1 0.4 -0.3
Body mass index (BMI) 0.1 0.3 0.4 0.6 -0.5
Impedance of leg (left) 0.2 0.8 1.2 -0.6 1.1
Leg predicted mass (left) 0.7 3.5 4.2 1.6 -2.1
Trunk fat mass 0.0 0.2 0.2 0.4 -0.4
Waist circumference 0.7 2.6 3.4 1.3 -1.9
Number of incorrect matches in round 0.4 0.6 1.1 -0.1 -1.1
Past tobacco smoking 0.1 0.1 0.2 0.5 0.2
Alcohol usually taken with meals 0.4 0.6 0.9 1.0 -0.5
Nervous feelings 1.9 3.5 4.1 1.7 -2.0
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 2.9 1.4 -1.7
Hearing difficulty/problems with background noise 0.3 0.6 0.7 -0.7 0.8
Hair/balding pattern: Pattern 2 1.2 1.6 1.8 -1.1 1.4
Had menopause 1.7 2.1 3.2 -1.8 1.0
Had other major operations 1.9 2.4 2.8 1.4 -1.7
Forced vital capacity (FVC) 0.5 1.8 2.3 1.2 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.4 5.1 2.3 -1.9
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.2 -0.3 0.5
Qualifications: None of the above 0.3 0.6 0.9 -0.6 0.9
Financial difficulties in last 2 years 2.0 2.8 2.8 1.6 -1.7
Mouth/teeth dental problems 0.4 0.6 0.7 0.8 -0.7
Heart attack 0.3 0.4 0.5 0.6 -0.7
Allergy 0.0 0.0 0.0 0.2 0.1
Pain all over the body in last month 4.8 5.1 7.1 1.8 -2.7
Diabetes (self-reported) 0.1 0.2 0.2 0.4 -0.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 1.5 1.2 -1.1
Medication: Ramipril 2.3 3.0 3.2 1.7 -1.8
Medication: Simvastatin 0.1 0.2 0.3 -0.6 0.2
Fluid intelligence score 0.0 0.0 0.1 -0.2 0.1
Illnesses of siblings 2.9 4.0 4.9 -1.8 2.2
Neuroticism score 0.1 0.3 0.3 0.6 -0.5
Weight 0.4 1.8 2.1 1.2 -1.5
Impedance of arm (right) 0.0 0.1 0.1 0.3 0.2
Arm fat percentage (right) 0.1 0.4 0.6 0.7 -0.5
Trunk fat-free mass 0.5 3.0 4.8 1.1 -2.2
Hip circumference 0.1 0.6 0.7 0.7 -0.8
Time employed in main current job 0.3 0.3 0.4 0.7 -0.4
Alcohol intake versus 10 years previously 0.1 0.2 0.3 -0.2 -0.5
Father’s age at death 0.2 0.3 0.4 0.4 -0.6
Worrier / anxious feelings 0.0 0.0 0.1 -0.3 -0.0
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 2.0 1.3 -1.4
Falls in the last year 4.4 6.0 6.9 2.3 -2.6
Hair/balding pattern: Pattern 3 0.8 1.2 1.3 1.0 -1.1
Number of live births 0.2 0.3 0.4 -0.6 0.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 1.6 1.2 -1.3
Pulse rate 1.0 1.7 1.7 1.3 -1.3
Happiness 0.4 0.5 0.6 0.8 -0.7
Noisy workplace 0.4 0.5 0.9 -0.9 0.4
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.1 -0.3 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.7 0.4 -0.8
Mouth/teeth dental problems: Dentures 0.3 0.6 0.7 0.8 -0.7
Asthma 0.2 0.3 0.4 -0.5 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.1 0.5
Medication: Cholesterol lowering 0.0 0.0 0.1 0.0 0.3
Depression (self-reported) 0.0 0.0 0.0 0.1 -0.2
Medication: Lansoprazole 0.3 0.3 0.3 -0.5 0.5
Prospective memory result 0.1 0.1 0.2 -0.4 0.4
Lung cancer (father) 2.3 2.6 2.9 -1.5 1.7
Illnesses of mother 0.2 0.3 0.4 -0.6 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 4.2 2.0 -2.0
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.0 -0.6
Impedance of arm (left) 0.1 0.5 0.9 -0.3 1.0
Arm fat mass (right) 0.1 0.6 0.6 0.8 -0.7
Trunk predicted mass 0.6 3.2 5.2 1.1 -2.3
Standing height 0.3 3.5 5.3 1.3 -2.3
Length of working week for main job 0.6 0.7 1.1 1.0 -0.5
Exposure to tobacco smoke at home 0.0 0.1 0.1 0.2 -0.2
Breastfed as a baby 0.3 0.4 0.7 -0.8 0.3
Tense / ‘highly strung’ 1.3 2.2 2.6 -1.6 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.0 0.2
Hair/balding pattern: Pattern 4 1.3 3.2 4.4 1.4 -2.1
Birth weight of first child 2.5 4.5 6.9 -2.6 1.5
Peak expiratory flow (PEF) 0.0 0.0 0.0 0.1 -0.1
Pulse wave reflection index 0.2 0.2 0.3 -0.3 -0.6
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.1 -1.1 0.7
Loud music exposure frequency 2.8 3.0 3.5 -1.9 1.6
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.4 0.0
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.0 -0.1 -0.2
Blood clot in the leg (DVT) 0.1 0.2 0.2 0.4 0.4
Medication: Paracetamol 3.2 5.2 5.6 2.4 -2.2
Headache pain in last month 3.9 6.6 8.2 2.9 -2.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.4 -0.6 0.4
Glaucoma (self-reported) 2.0 2.4 2.7 1.4 -1.6
Gout (self-reported) 0.6 0.8 1.2 -1.1 0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 -0.5 0.8
Medication: Amlodipine 0.0 0.0 0.0 0.0 0.1
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.0 0.9 -1.0
Birth weight 0.2 0.3 0.3 0.6 -0.6
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.3 -0.5 -0.1
High blood pressure (siblings) 5.0 7.2 7.7 2.8 -2.6
Forced vital capacity (FVC), Best measure 0.9 3.4 4.0 1.7 -2.0
Body fat percentage 0.0 0.0 0.1 0.3 0.1
Leg fat percentage (right) 0.1 0.3 0.5 0.7 -0.4
Arm fat-free mass (right) 0.3 1.3 2.1 0.7 -1.5
Exposure to tobacco smoke outside home 0.5 0.7 0.8 0.9 -0.7
Comparative body size at age 10 0.4 1.2 1.7 1.3 -0.8
Number of full brothers 0.4 0.5 0.9 -0.9 0.3
Worry too long after embarrassment 1.2 2.1 2.3 1.5 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.2 1.8 0.8 -1.3
Wheeze or whistling in the chest in last year 0.3 0.6 0.8 -0.6 0.9
Number of children fathered 0.0 0.0 0.0 -0.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 0.8 -0.9 0.8
Age at first live birth 0.4 0.6 1.2 1.1 -0.2
Pulse wave peak to peak time 0.2 0.2 0.4 0.0 0.7
Health satisfaction 3.5 4.6 4.6 -2.1 2.1
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.1 0.4
Qualifications: College or University degree 1.9 6.1 7.3 2.7 -2.2
Eye problems/disorders: None of the above 2.3 2.6 3.0 -1.5 1.7
Mouth/teeth dental problems: Loose teeth 0.5 0.7 1.1 0.5 -1.0
Emphysema/chronic bronchitis 0.0 0.0 0.0 0.1 -0.0
Medication for pain relief, constipation, heartburn 0.2 0.4 0.5 -0.7 0.5
Neck or shoulder pain in last month 2.9 4.2 5.8 2.4 -1.6
Medication: Blood pressure 1.1 1.9 2.7 1.6 -1.1
Angina (self-reported) 0.5 0.6 0.7 -0.8 0.7
Migraine (self-reported) 0.0 0.0 0.0 0.2 -0.0
Medication: Ibuprofen 0.0 0.1 0.1 0.0 0.3
Medication: Allopurinol 0.1 0.1 0.3 0.0 -0.5
Medication: Omeprazole 0.4 0.5 0.8 0.9 -0.5
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.4 0.5
Mean time to correctly identify matches 4.4 8.4 9.0 2.8 -3.0
Heart disease (mother) 0.3 0.3 0.6 -0.2 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 2.4 -0.9 1.5
Whole body fat mass 0.1 0.3 0.4 0.6 -0.5
Leg fat mass (right) 0.3 1.0 1.3 1.1 -0.9
Arm predicted mass (right) 0.2 0.8 1.5 0.4 -1.2
Pulse rate, automated reading 0.1 0.2 0.3 -0.5 0.2
Alcohol intake frequency. 0.3 0.6 1.0 -1.0 0.5
Comparative height size at age 10 0.6 3.0 4.7 1.2 -2.2
Number of full sisters 1.3 1.6 2.0 1.1 -1.4
Suffer from ‘nerves’ 0.1 0.2 0.2 0.4 -0.4
Overall health rating 0.9 2.0 2.7 1.1 -1.6
Chest pain or discomfort 0.5 0.7 1.2 0.5 -1.1
Had major operations 0.2 0.2 0.2 -0.4 0.4
Age at last live birth 2.3 3.3 4.5 2.1 -1.5
Family relationship satisfaction 0.0 0.0 0.0 -0.1 0.2
Leg pain on walking 0.2 0.2 0.3 -0.4 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.6 -0.8 0.4
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.5 -0.6 0.7
Illness, injury, bereavement, stress in last 2 years 1.6 2.0 2.9 -1.0 1.7
Medication: Aspirin 0.0 0.0 0.0 -0.1 -0.0
Supplements: Vitamin C 0.0 0.0 0.0 -0.1 -0.0
Knee pain experienced in last month 0.5 0.7 1.3 1.2 -0.4
Hypertension (Self-reported) 0.9 2.4 3.4 1.8 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 -0.3 0.4
Illnesses of father: Heart disease 0.2 0.2 0.5 -0.7 0.0
Illnesses of siblings: Diabetes 0.6 0.7 0.9 0.7 -0.9
Smoking status: Previous 0.0 0.1 0.1 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 -0.3 0.1
Whole body fat-free mass 0.5 3.1 4.5 1.3 -2.1
Leg fat-free mass (right) 0.5 2.6 3.3 1.4 -1.8
Arm fat percentage (left) 0.0 0.2 0.3 0.6 -0.2
Average weekly red wine intake 0.1 0.2 0.3 0.3 -0.5
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.1 0.3
Mood swings 1.6 2.9 3.0 1.7 -1.6
Loneliness, isolation 2.7 3.7 3.8 -2.0 1.9
Long-standing illness, disability or infirmity 4.7 7.2 8.5 2.4 -2.9
Ever had bowel cancer screening 2.1 2.4 3.0 -1.7 1.3
Diabetes diagnosed by doctor 0.0 0.0 0.0 0.1 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 4.3 4.6 5.0 2.2 -2.1
Friendships satisfaction 0.8 1.0 1.2 -0.9 1.1
Qualifications: nursing, teaching 0.2 0.3 0.6 0.2 -0.8
Commuting to job workplace: Walk 2.1 2.3 2.8 1.3 -1.7
Eye problems/disorders: Cataract 0.1 0.1 0.1 0.4 -0.0
Mouth/teeth dental problems: Mouth ulcers 2.4 3.8 4.8 -1.7 2.2
Medication for cholesterol 2.3 3.5 5.0 -1.4 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 0.6 -0.0
Back pain experienced in last month 1.3 1.9 1.9 1.4 -1.4
Mineral and other dietary supplements 0.1 0.2 0.4 -0.0 0.6
Breast cancer (self-reported) 0.6 0.8 0.8 0.9 -0.8
Asthma (self-reported) 0.2 0.4 0.4 -0.6 0.6
Osteoporosis (self-reported) 2.0 2.5 3.0 -1.7 1.4
Osteoarthritis (self-reported) 0.9 1.2 1.5 0.9 -1.2
Medication: Aspirin 0.1 0.1 0.1 0.1 -0.4
Medication: Gliclazide 0.1 0.1 0.2 0.4 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.3 0.4 -0.6 0.3
Smoking status: Current 0.3 0.4 0.7 0.8 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.3 5.0 5.6 2.4 -2.1
Whole body water mass 0.5 3.1 4.6 1.3 -2.1
Leg predicted mass (right) 0.5 2.6 3.3 1.4 -1.8
Arm fat mass (left) 0.1 0.5 0.6 0.8 -0.7
Number of self-reported non-cancer illnesses 1.9 3.3 4.0 2.0 -1.6
Average weekly champagne plus white wine intake 2.8 3.8 4.3 2.1 -1.8
Miserableness 0.3 0.6 0.8 0.9 -0.6
Guilty feelings 0.1 0.1 0.1 0.2 0.3
Wears glasses or contact lenses 0.2 0.2 0.4 -0.1 0.6
Ever taken oral contraceptive pill 0.2 0.2 0.4 -0.2 0.6
Hearing aid user 0.8 0.9 1.0 -0.9 1.0
Mother’s age at death 0.0 0.0 0.0 -0.2 -0.1
Financial situation satisfaction 0.5 0.6 0.8 -0.6 0.9
Tinnitus: Yes, now most or all of the time 0.6 0.7 0.7 0.8 -0.8
Commuting to job workplace: Public transport 0.0 0.0 0.0 -0.0 -0.1
Eye problems/disorders: Glaucoma 1.7 2.0 2.4 1.3 -1.6
Medication: Blood pressure 1.2 2.3 2.8 1.3 -1.7
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.7 0.8 -0.3
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.5 0.1 -0.7
High cholesterol (Self-reported) 0.3 0.5 0.7 -0.8 0.5
Medication: Bendroflumethiazide 2.8 4.2 4.3 2.0 -2.1
Medication: Paracetamol 3.1 4.8 5.1 2.1 -2.3
Medication: Lisinopril 3.4 4.3 4.5 2.1 -2.0
Medication: Atorvastatin 0.1 0.1 0.2 0.3 -0.4
Illnesses of father: High blood pressure 0.1 0.1 0.1 0.2 0.3
Alcohol drinker status: Never 5.1 6.1 8.1 -2.9 2.0
Ever smoked 0.1 0.2 0.4 -0.6 0.0
Basal metabolic rate 0.5 3.0 4.3 1.3 -2.1
Leg fat percentage (left) 0.1 0.2 0.3 0.6 -0.2
Arm fat-free mass (left) 0.3 1.8 2.9 0.8 -1.7
Number of operations (self-reported) 1.1 1.6 1.8 1.3 -1.2
Average weekly beer plus cider intake 0.0 0.0 0.0 -0.2 0.1
Irritability 0.2 0.3 0.4 -0.7 0.3
Risk taking 0.2 0.3 0.5 0.7 -0.4
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 -0.1 0.1
Fractured/broken bones in last 5 years 2.8 3.6 3.8 2.0 -1.9
Age started oral contraceptive pill 0.4 0.5 0.7 -0.8 0.6
Diastolic blood pressure, automated reading 0.1 0.3 0.5 0.7 -0.3
Ever depressed for a whole week 0.0 0.1 0.1 -0.3 0.0
Unable to work because of sickness or disability 2.8 3.6 3.8 1.9 -1.9
Commuting to job workplace: Cycle 0.1 0.2 0.3 0.5 -0.1
Myopia 0.3 0.5 0.5 -0.7 0.7
Vascular/heart problems diagnosed by doctor 0.9 2.6 3.6 -1.9 1.2
Cholesterol lowering medication 0.1 0.1 0.2 -0.5 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.3 1.2 -0.8
Pain experienced in last month 2.4 4.0 5.1 -2.3 1.7
Supplements: Calcium 2.3 2.5 3.1 -1.8 1.4
Basal cell carcinoma (self-reported) 3.7 4.5 4.8 -2.0 2.2
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 0.4 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.2 0.3 0.5
Heart disease (siblings) 0.1 0.1 0.2 -0.4 0.0
Alcohol drinker status: Previous 0.4 0.4 0.5 0.6 -0.7
Pack years of smoking 0.3 0.5 0.7 0.9 -0.5
Impedance of whole body 0.1 0.7 1.2 -0.5 1.1
Leg fat mass (left) 0.3 1.1 1.4 1.2 -0.9
Arm predicted mass (left) 0.4 2.1 3.5 0.9 -1.9