Hub : Genes

PPAPDC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0519	0.0248	2.4e-02	0.011	0.000	0.014	0.011	0.013	8.2e-03	3.6e-01	2.9e-03	6.6e-03	4.0e-03
2	YFS	Blood	0.1850	0.0281	0.0e+00	0.107	0.098	0.110	0.122	0.114	3.5e-33	1.8e-30	4.1e-34	7.5e-38	3.0e-35
3	TCGA	Breast Invasive Carcinoma	0.0631	0.0261	2.1e-04	0.008	0.022	0.033	NA	0.020	8.5e-03	2.2e-05	2.1e-07	NA	4.9e-05
4	TCGA	Brain Lower Grade Glioma	0.0787	0.0307	1.4e-05	0.026	0.024	0.033	NA	0.036	5.1e-04	8.8e-04	1.2e-04	NA	6.0e-05
5	TCGA	Prostate Adenocarcinoma	0.1233	0.0457	1.3e-04	0.007	0.032	0.037	NA	0.031	6.2e-02	2.2e-04	9.4e-05	NA	2.8e-04
6	TCGA	Skin Cutaneous Melanoma	0.2950	0.1180	5.3e-04	0.075	0.096	0.142	NA	0.138	4.8e-03	1.5e-03	1.3e-04	NA	1.6e-04
7	TCGA	Thyroid Carcinoma	0.1030	0.0410	6.5e-07	0.099	0.092	0.108	NA	0.090	6.6e-10	2.9e-09	1.3e-10	NA	4.5e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.0	3.2	7.2	2.0	1.2	-1.2	1.9	1.3	2.7	-1.7
Bipolar Disorder or Schizophrenia	0.9	2.1	4.6	1.4	0.6	-1.7	1.5	-0.1	2.1	-1.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	-0.5	0.1	-0.3	-0.3	-0.4	-0.8	0.1
Depression (Nagel 2018)	0.8	1.3	3.5	-0.3	1.1	-0.9	1.5	0.6	0.9	-1.9
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.6	0.5	0.0	-0.8	0.0	-0.1	0.2	0.0
Neuroticism (Nagel 2018)	0.1	0.2	0.8	0.0	0.9	-0.2	0.7	-0.1	0.3	-0.6
Schizophrenia (2018)	0.3	0.6	1.5	0.1	-0.2	-1.2	0.3	-1.2	0.6	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	-0.8	0.2	0.7	-0.3	0.2	0.9	-0.1
Worry (Nagel 2018)	0.6	1.3	3.1	1.0	1.8	0.6	1.4	0.5	0.3	-1.4
Alzheimer’s Disease (in mother)	1.2	1.4	5.8	-1.1	0.3	0.1	0.5	-0.4	2.4	-1.5
Alzheimer’s Disease (in father)	1.3	1.4	3.6	0.6	1.1	-0.7	1.2	1.9	1.6	-0.7
Alzheimer’s Disease (including proxy)	2.5	3.6	12.0	0.2	1.4	-0.2	1.9	1.3	3.5	-2.4
Crohns Disease (2017)	0.5	1.0	2.4	-1.3	-0.4	0.7	-1.5	1.1	-0.7	0.8
Irritable Bowel Disease (IBD)	0.7	1.7	6.4	-2.5	-0.6	0.1	-2.0	1.1	0.2	0.4
Ulcerative Colitis (UC)	0.7	1.3	5.4	-2.3	0.0	0.2	-1.4	1.0	1.0	-0.2
Major Depression (MDD)	2.0	2.5	8.4	-2.9	-1.7	-1.3	-0.9	-1.7	0.4	0.4
Reaction Time	1.3	2.6	5.9	0.1	1.5	-2.4	1.7	-0.8	1.6	-1.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.1	0.7	-0.1	0.1	0.2	0.6	-1.5	0.3
Breast Cancer	1.2	2.9	6.5	-1.2	-2.1	-1.1	-1.6	-2.0	-0.8	2.5
Ovarian Cancer	0.4	0.5	1.8	1.4	0.6	0.2	0.5	0.1	0.2	-0.9
Prostate Cancer	1.4	1.9	3.3	-1.5	-1.8	-1.2	-1.2	-1.8	-0.8	1.1
Age at First Birth	0.1	0.2	0.6	0.4	0.1	0.2	-0.3	0.8	-0.4	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.2	0.0	0.5	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	3.9	-0.2	1.1	-1.9	1.1	-0.5	0.8	-2.0
Coronary Artery Disease (CAD)	0.1	0.2	0.5	0.5	-0.1	0.1	0.1	0.5	-0.4	0.7
Crohns Disease (2012)	0.4	0.6	2.5	-1.6	-0.3	0.2	-0.8	0.8	0.5	0.1
Mean Putamen Volume	0.4	0.5	1.1	-0.6	1.0	-0.9	0.4	0.2	0.5	-0.9
Fasting Glucose	0.3	0.3	1.0	0.5	0.2	-0.6	0.5	0.4	1.0	-0.3
HbA1C	1.1	1.2	3.8	-0.2	-1.1	-2.0	0.3	-1.5	0.7	0.8
HDL Cholesterol	0.2	0.4	1.0	-0.4	-0.9	0.3	-0.7	0.1	0.1	1.0
LDL Cholesterol	0.3	0.5	1.3	0.4	0.5	0.8	-0.0	-0.3	1.2	-0.8
Lupus	0.6	0.9	2.5	0.2	0.2	-1.6	0.8	0.1	1.6	-0.6
Neuroticism (2016)	0.3	0.4	1.0	-0.9	-1.0	-0.6	-0.5	-0.3	0.4	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.7	-0.0	-1.0	0.4	-0.8	0.6	-0.7
Rheumatoid Arthritis	0.4	0.5	1.3	0.4	-0.6	0.6	-0.7	-0.2	-1.0	1.2
Schizophrenia (2014)	0.4	0.9	1.8	1.1	0.6	-0.7	0.9	-0.3	1.2	-1.4
Triglycerides	0.1	0.2	0.8	0.9	-0.2	-0.6	0.2	-0.5	-0.4	0.2
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.0	1.7	1.2	2.0	0.8	1.3	-0.2	-0.5
Ulcerative Colitis	1.1	1.6	4.0	-1.5	0.1	-2.0	-0.6	-0.0	1.9	-1.0
Blood Eosinophil Count	0.4	3.3	9.7	0.5	1.3	3.0	1.2	3.1	-0.4	-0.8
Blood Platelet Count	7.0	80.7	151.3	10.1	9.7	9.7	9.8	12.3	3.7	-3.7
Blood Red Count	7.3	71.0	130.0	5.8	10.5	4.2	9.5	11.4	4.9	-9.5
Blood White Count	2.4	18.0	59.1	2.8	4.1	4.0	3.1	7.7	2.3	-3.4
Heel T-Score	1.2	9.1	17.7	1.0	4.2	-1.5	3.7	2.0	3.0	-4.0
BMI	0.5	3.0	8.2	0.4	1.1	-1.6	1.8	0.4	2.9	-2.3
Height	0.2	3.1	6.8	0.7	2.6	1.7	2.0	1.1	0.4	-2.5
Waist Hip Ratio (WHR)	1.6	7.2	16.6	2.0	4.1	-0.1	3.8	2.2	1.3	-3.0
Systolic Blood Pressure	0.2	1.0	2.6	0.3	1.6	0.4	0.7	1.3	0.7	-1.1
Smoking Status	0.3	0.8	2.0	0.7	1.4	-0.8	0.6	1.1	-0.2	-0.9
Allergy or Eczema	0.4	1.0	2.8	0.8	0.6	0.3	0.5	1.2	1.0	-1.7
Cardiovascular Disease	0.5	1.6	3.0	-0.3	1.7	-0.5	1.5	0.1	1.7	-1.7
Hypothyroidism (self reported)	0.3	0.8	2.3	0.9	-0.6	-0.7	0.8	-0.5	1.5	-0.7
Respiratory disease	0.8	1.7	3.6	0.3	1.8	1.5	1.3	1.9	-0.6	-0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-0.3	-1.0	-0.8	-0.1	-0.5	0.7	0.3
Lung FEV1/FVC ratio	0.1	0.3	1.4	-0.0	-0.5	0.4	-0.2	-0.1	1.2	-0.3
Lung FVC	0.4	2.1	4.7	-2.2	-2.1	-0.8	-1.8	-1.2	-0.5	0.2
Neuroticism	0.7	1.7	3.8	0.6	1.6	0.1	1.4	0.4	1.7	-2.0
Chronotype (morning person)	0.3	0.7	2.2	0.0	-1.0	-0.1	-0.6	-0.1	-1.1	1.5
Hair Pigment	0.0	0.9	2.0	0.7	0.7	0.7	1.0	1.4	-1.1	-0.6
Tanning	0.1	0.7	2.1	1.5	0.2	-1.1	0.9	-0.0	0.7	-0.3
Hand grip strength (left)	3.2	8.4	14.0	-2.9	-3.7	0.9	-3.5	-2.5	-3.1	2.7
Number of treatments/medications taken	1.0	1.7	5.9	-0.7	0.5	-1.8	0.6	-0.7	2.4	-1.2
Average weekly spirits intake	0.9	1.1	5.5	0.2	-0.1	-1.0	-0.5	-2.4	-0.9	-0.2
Sensitivity / hurt feelings	0.4	0.7	2.3	0.1	0.3	0.8	0.8	0.5	1.5	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	-0.5	0.5	-0.8	0.7	0.1	1.4	-1.2
Hearing difficulty/problems: Yes	2.6	3.9	7.2	2.1	2.4	1.9	2.1	2.7	0.3	-1.3
Relative age of first facial hair	0.0	0.0	0.2	-0.1	-0.4	-0.3	-0.1	-0.1	-0.1	0.2
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	16.0	-1.1	-0.7	-2.1	-0.2	-1.4	4.0	-1.3
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.7	-1.4	-0.6	0.5	-1.6	-0.6	-1.1	1.4
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	-0.1	0.2	0.3
Systolic blood pressure, automated reading	0.2	0.5	2.0	-1.4	-0.0	0.4	-0.7	0.7	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.2	-0.8	-0.2	-0.5	-0.3	0.3	0.4
Angina	1.7	2.2	6.5	-2.6	-1.1	-0.0	-1.6	-2.2	0.0	0.2
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.8	0.5	0.2	-0.2	-0.6	-0.1	-0.1
Vitamin and mineral supplements	0.3	0.4	1.2	-0.5	-0.8	-1.1	-0.7	-0.2	-0.5	0.4
Supplements: Zinc	1.1	1.2	3.0	1.7	1.1	0.5	1.5	0.8	0.1	-1.0
Medication: Co-codamol	1.3	1.6	2.9	-0.4	1.7	0.3	1.6	0.4	1.4	-1.7
Medication: Metformin	0.5	0.7	3.9	0.2	0.3	-0.8	0.5	-0.2	2.0	-0.2
Diabetes (father)	0.5	0.6	1.4	-0.5	0.7	1.2	0.3	1.2	0.1	-0.9
Diabetes (mother)	0.7	0.9	2.5	0.5	0.8	-1.6	1.2	-0.9	0.3	-0.6
Severe depression (siblings)	0.6	0.7	2.0	1.4	0.0	-0.8	0.5	-0.5	1.1	-0.5
Pack years adult smoking proportion	0.9	1.3	3.2	0.5	1.5	-0.2	0.7	1.3	1.8	-1.1
Impedance of leg (right)	0.1	0.5	1.4	-0.7	0.7	1.2	-0.1	0.0	-0.9	0.7
Leg fat-free mass (left)	1.2	6.4	12.5	2.3	2.3	-1.0	3.4	1.4	2.7	-3.5
Trunk fat percentage	0.9	3.8	6.9	1.8	2.2	0.6	2.6	2.2	1.9	-1.7
Hand grip strength (right)	3.5	9.6	16.4	-3.6	-4.1	0.1	-3.8	-3.3	-2.3	2.7
Townsend deprivation index at recruitment	0.2	0.2	1.2	-0.2	-0.2	1.1	-0.1	0.1	-0.1	0.5
Current tobacco smoking	1.8	3.0	5.3	0.8	1.7	-1.3	2.0	2.1	2.3	-1.5
Average weekly fortified wine intake	0.4	0.4	1.6	-0.1	-0.4	0.1	-0.5	0.1	-1.3	1.0
Maternal smoking around birth	0.5	0.8	1.6	-1.3	-1.0	-0.7	-0.5	-1.0	1.1	0.2
Fed-up feelings	0.1	0.2	0.7	-0.3	0.4	0.1	0.4	-0.0	0.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.8	0.0	1.0	0.0	1.3	0.9	0.4	-1.1
Relative age voice broke	0.9	1.4	3.0	-0.7	-1.7	-1.3	-1.1	-1.6	-0.0	1.1
Taking other prescription medications	1.9	2.9	7.9	-0.0	1.4	-1.4	1.8	0.1	2.8	-2.3
Age when periods started (menarche)	0.5	1.2	3.2	-0.4	0.8	1.8	-0.2	1.4	-1.5	0.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	5.4	-0.9	-0.1	-2.3	-0.1	-1.2	0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.2	9.5	1.7	2.8	-0.8	3.1	1.4	0.9	-2.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.1	-0.3	-0.2	0.3	-0.8	0.7	0.3
Qualifications: CSEs or equivalent	0.5	0.7	3.6	0.1	-0.7	0.1	-0.2	-0.6	1.9	0.3
Serious illness, injury or assault to yourself	0.8	1.0	2.2	-0.2	1.1	-0.5	1.0	0.4	1.5	-1.4
High blood pressure	0.2	0.5	1.6	-0.1	0.9	-0.2	0.9	1.3	-0.1	-0.6
Hayfever, allergic rhinitis or eczema	1.4	2.9	6.7	1.5	1.5	-0.8	1.4	1.4	2.2	-2.6
Multivitamins +/- minerals	1.0	1.2	2.5	1.2	1.6	0.8	1.4	0.6	0.8	-1.0
Stomach or abdominal pain in last month	0.3	0.3	0.8	0.5	0.1	-0.8	0.6	-0.9	0.1	-0.3
Supplements: Glucosamine	0.2	0.3	1.2	1.0	-0.1	0.2	0.2	0.4	-1.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	-0.3	0.5	0.1	0.1	0.2	-0.8	0.3
Medication: Atenolol	0.4	0.5	1.5	-1.2	-0.1	-0.6	0.2	-0.3	0.8	-0.8
Medication: Levothyroxine sodium	0.1	0.3	1.3	0.2	-1.1	-0.2	-0.1	0.1	0.4	0.5
Sitting height	0.3	2.0	4.6	1.4	1.8	0.0	2.1	0.5	0.3	-2.0
Chronic bronchitis/emphysema (father)	1.7	2.0	3.5	-0.7	-1.9	-1.8	-1.8	-1.1	-0.8	1.5
High blood pressure (mother)	1.5	2.0	5.5	2.3	1.3	-0.1	2.0	-0.1	0.3	-1.7
Body mass index (BMI)	0.8	3.5	7.7	1.2	1.5	-0.8	2.3	1.4	2.8	-2.2
Impedance of leg (left)	0.2	0.9	1.5	-1.1	-0.2	1.0	-1.0	-0.4	-1.2	1.2
Leg predicted mass (left)	1.2	6.5	12.7	2.3	2.4	-1.0	3.4	1.4	2.7	-3.6
Trunk fat mass	1.3	5.4	9.9	2.0	2.6	0.1	3.1	2.1	2.5	-2.5
Waist circumference	2.1	7.8	13.9	1.7	3.3	-1.2	3.7	2.4	3.1	-3.2
Number of incorrect matches in round	0.2	0.3	0.8	-0.9	-0.1	0.5	-0.4	-0.1	-0.5	0.5
Past tobacco smoking	0.6	1.1	2.7	0.9	0.7	-0.4	1.6	0.8	1.4	-0.9
Alcohol usually taken with meals	0.3	0.5	1.4	-0.5	-0.1	0.3	-0.8	-0.6	-1.2	0.8
Nervous feelings	1.4	2.6	5.4	0.8	2.3	-0.4	2.0	0.8	1.5	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.7	0.8	1.2	-0.6	1.5	0.3	2.2	-2.1
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.0	-0.5	0.2	-0.5	-0.1	0.1	0.5
Hair/balding pattern: Pattern 2	0.3	0.4	1.7	0.3	-0.1	0.3	-0.1	-0.5	-1.3	0.9
Had menopause	1.1	1.3	2.9	-0.5	-1.0	1.2	-1.4	0.1	-1.7	1.3
Had other major operations	1.1	1.3	3.4	-0.7	1.2	0.0	0.6	1.3	1.3	-1.9
Forced vital capacity (FVC)	0.6	2.3	8.9	-1.0	-1.6	-1.1	-0.9	-3.0	-1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.7	0.5	2.2	-1.1	2.2	0.7	1.3	-1.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.0	0.5	0.0	1.3	-0.2	0.7	-1.4	1.1
Qualifications: None of the above	0.2	0.5	0.7	0.6	0.8	0.9	0.8	0.5	0.0	0.7
Financial difficulties in last 2 years	0.6	0.8	2.0	0.4	1.2	-0.4	0.6	0.6	1.4	-1.0
Mouth/teeth dental problems	0.5	0.7	2.3	-0.7	-1.2	-1.5	-0.7	-0.4	0.2	-0.4
Heart attack	0.8	1.0	3.2	-0.8	1.2	1.8	0.7	0.2	-0.1	-0.9
Allergy	0.7	1.7	3.2	-1.3	-1.3	-0.2	-1.1	-1.8	-0.9	1.8
Pain all over the body in last month	1.9	2.1	6.2	0.2	1.0	-1.1	1.0	0.1	2.5	-2.2
Diabetes (self-reported)	0.5	0.7	3.0	-0.5	-1.0	-0.5	0.1	-0.7	1.7	-0.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.1	-0.3	0.3	-0.9	0.4	0.9	1.5	-1.8
Medication: Ramipril	0.2	0.3	0.8	-0.4	0.9	-0.7	-0.1	0.4	0.4	-0.6
Medication: Simvastatin	0.7	1.0	3.2	-1.3	-0.7	-1.1	0.0	-0.4	1.8	-0.4
Fluid intelligence score	0.2	0.4	1.5	1.2	0.3	0.1	0.1	0.4	-1.1	-0.0
Illnesses of siblings	0.8	1.1	5.8	2.4	0.5	0.6	0.8	0.8	0.2	0.2
Neuroticism score	0.5	1.0	2.5	0.3	0.9	-0.5	1.2	-0.3	1.6	-1.2
Weight	1.3	6.4	11.1	2.0	2.5	-0.8	3.3	1.8	3.0	-3.2
Impedance of arm (right)	0.3	1.4	2.6	1.5	1.4	1.0	0.6	0.5	-1.6	1.2
Arm fat percentage (right)	1.2	4.9	8.0	1.8	2.6	-0.1	2.8	2.0	2.6	-2.2
Trunk fat-free mass	0.7	3.9	10.9	0.8	1.3	-1.1	2.1	0.7	2.8	-3.3
Hip circumference	0.7	2.9	5.3	1.4	1.5	-0.6	2.3	1.5	2.0	-2.1
Time employed in main current job	0.8	0.9	1.5	-1.2	-1.0	-0.7	-1.2	-0.6	0.3	1.1
Alcohol intake versus 10 years previously	0.3	0.4	1.9	-0.0	-0.0	-0.7	0.1	0.1	1.4	-0.5
Father’s age at death	0.4	0.5	2.0	0.6	0.4	-0.3	0.6	0.6	1.4	-0.7
Worrier / anxious feelings	0.3	0.6	1.3	0.9	1.2	0.4	1.1	0.3	0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	5.2	-1.2	0.6	-1.2	0.9	-0.7	2.3	-1.4
Falls in the last year	2.3	3.1	6.6	0.5	2.5	-1.1	2.6	1.7	0.8	-2.1
Hair/balding pattern: Pattern 3	0.9	1.3	4.0	-2.0	-0.6	-0.4	-1.1	-1.8	-0.5	-0.1
Number of live births	0.4	0.5	2.5	1.0	0.5	-0.3	-0.1	-1.6	0.0	0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	9.0	-0.7	-1.6	-0.8	-0.8	-3.0	-0.6	-0.2
Pulse rate	0.9	1.5	3.0	0.2	1.1	-1.2	1.2	1.7	1.6	-1.0
Happiness	0.6	0.7	3.5	-1.9	-0.4	0.2	-0.7	-0.3	0.8	0.1
Noisy workplace	0.1	0.1	0.4	-0.4	-0.3	0.3	-0.6	0.2	-0.1	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	-0.2	-0.9	0.4	-0.5	-0.3	-0.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.5	0.7	1.4	0.7	1.5	1.9	1.2	-1.3
Mouth/teeth dental problems: Dentures	0.2	0.3	1.4	-0.5	0.4	-1.2	0.4	-0.3	-0.5	-0.4
Asthma	0.5	1.0	2.0	0.1	1.4	0.7	1.0	1.4	0.5	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	1.0	2.1	-1.5	-1.3	-1.1	-0.8	-0.9	0.1	0.3
Medication: Cholesterol lowering	1.8	2.8	6.1	-1.4	-2.4	-1.5	-1.5	-2.5	1.1	0.8
Depression (self-reported)	0.9	1.0	3.1	-0.0	0.3	1.8	-0.4	1.7	-0.7	0.6
Medication: Lansoprazole	0.7	0.8	2.4	1.5	1.3	-0.1	1.1	-0.5	0.4	-0.1
Prospective memory result	0.3	0.3	0.8	0.3	0.5	-0.1	0.6	0.9	0.8	-0.3
Lung cancer (father)	0.5	0.6	1.7	0.0	-0.4	0.9	-1.1	-0.5	-0.3	1.3
Illnesses of mother	0.7	0.9	2.3	-0.5	-1.5	-0.6	-0.5	-1.1	0.7	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.8	0.0	-0.2	-0.9	0.5	-2.0	0.4	-1.6
Pulse wave Arterial Stiffness index	1.1	1.3	3.7	0.6	1.9	0.2	1.2	1.7	0.7	-0.6
Impedance of arm (left)	0.3	1.5	3.0	1.5	1.0	1.2	0.4	0.4	-1.7	1.5
Arm fat mass (right)	1.3	5.2	8.6	2.0	2.4	-0.3	2.9	2.1	2.7	-2.5
Trunk predicted mass	0.7	3.8	11.0	0.8	1.3	-1.0	2.1	0.7	2.8	-3.3
Standing height	0.4	3.5	7.1	1.9	2.4	-0.1	2.7	1.0	0.9	-2.5
Length of working week for main job	1.2	1.4	6.0	-0.7	0.1	-1.0	0.6	0.0	2.5	-1.3
Exposure to tobacco smoke at home	1.6	1.8	3.1	0.2	1.6	0.7	1.8	1.7	1.3	-1.4
Breastfed as a baby	1.0	1.3	2.2	-0.9	-1.5	-0.1	-1.4	-1.2	-0.3	1.5
Tense / ‘highly strung’	0.6	1.0	2.4	-0.1	-1.2	-0.1	-1.1	-1.4	-0.5	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.1	0.3	0.8	0.4	1.7	1.2	1.8	-1.3
Hair/balding pattern: Pattern 4	0.8	1.9	4.5	0.6	1.6	1.1	1.1	2.1	1.2	-1.3
Birth weight of first child	0.6	1.1	2.6	0.3	-1.6	0.7	-1.4	-0.8	-0.4	1.3
Peak expiratory flow (PEF)	0.2	0.6	2.5	0.3	-1.1	-0.1	-0.4	-1.6	0.0	0.1
Pulse wave reflection index	0.4	0.4	1.3	0.7	0.9	1.1	0.4	-0.2	-0.4	0.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	0.1	-0.6	-1.1	-0.3	-0.3	0.6	0.3
Loud music exposure frequency	1.6	1.8	2.9	-1.7	-1.2	-0.9	-1.7	-1.6	0.9	1.0
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	5.8	-1.3	-1.5	-2.1	-1.8	-2.4	0.1	0.5
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	7.3	1.8	2.0	2.7	1.1	1.7	-0.9	0.1
Blood clot in the leg (DVT)	1.0	1.3	3.8	1.1	0.5	2.0	0.2	1.4	-1.4	-0.0
Medication: Paracetamol	0.6	1.0	3.9	0.3	0.9	-2.0	0.4	-1.2	0.5	-0.4
Headache pain in last month	2.2	3.7	8.8	1.8	3.0	-0.9	2.5	0.9	1.5	-1.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	1.0	0.4	0.7	0.3	0.9	-0.9	0.1
Glaucoma (self-reported)	0.6	0.7	2.1	0.5	1.1	-0.5	1.0	-0.3	-0.2	-1.4
Gout (self-reported)	0.7	0.9	2.3	-1.5	-1.1	-0.9	-0.6	-1.2	0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.4	1.0	-0.9	-0.2	0.6	-0.2	1.2	-0.2
Medication: Amlodipine	0.5	0.8	4.7	-2.2	0.2	0.7	0.1	-0.1	-0.1	-0.3
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.9	0.1	1.0	-2.2	2.1	0.3	2.2	-2.0
Birth weight	0.1	0.2	0.9	0.2	0.9	0.1	0.6	0.2	-0.6	-0.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.0	1.4	0.9	1.1	0.5	0.7	-0.1	-0.7
High blood pressure (siblings)	1.2	1.7	5.5	-2.3	-0.0	-2.1	-0.2	-1.0	0.5	-1.0
Forced vital capacity (FVC), Best measure	0.3	1.2	4.6	-0.5	-0.5	-1.2	0.1	-2.1	-0.3	-1.3
Body fat percentage	0.9	3.7	6.4	1.5	2.2	0.3	2.5	2.0	2.2	-1.8
Leg fat percentage (right)	1.1	4.0	7.1	0.8	2.3	-0.2	2.7	1.7	2.6	-2.2
Arm fat-free mass (right)	0.6	2.9	8.1	0.5	0.8	-1.0	1.8	0.7	2.5	-2.8
Exposure to tobacco smoke outside home	2.6	3.5	8.8	1.2	0.6	-3.0	2.0	-0.9	2.5	-1.8
Comparative body size at age 10	0.5	1.3	4.3	-0.1	-0.5	-2.1	0.7	-0.9	1.7	-0.4
Number of full brothers	0.3	0.3	1.0	-1.0	-0.2	0.5	-0.8	0.2	0.3	-0.3
Worry too long after embarrassment	2.2	3.6	7.1	1.5	1.9	-1.3	2.5	-0.0	2.7	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	4.7	1.2	1.7	-0.1	2.2	1.5	1.3	-1.9
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	1.0	0.7	-0.3	1.0	1.2	0.3	-0.9
Number of children fathered	0.5	0.5	1.6	-0.3	-1.0	0.7	-0.7	-0.0	-1.3	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.7	-0.7	-0.7	0.8	-1.6	-1.0	-0.7	1.2
Age at first live birth	1.7	3.0	6.2	-2.5	-1.7	-0.7	-1.8	-1.9	-1.8	1.2
Pulse wave peak to peak time	0.9	1.0	3.0	-0.5	-1.7	-0.1	-1.0	-1.5	-0.8	0.6
Health satisfaction	2.1	2.7	5.0	-2.2	-1.9	-0.8	-1.5	-1.9	1.8	0.7
Shortness of breath walking on level ground	0.4	0.5	2.1	-1.5	0.3	0.5	-0.3	0.6	-0.1	0.6
Qualifications: College or University degree	0.4	1.1	3.8	-1.0	1.0	-1.0	0.8	0.5	0.4	-2.0
Eye problems/disorders: None of the above	0.5	0.6	1.6	0.2	-0.7	-0.3	-0.7	0.1	-1.3	1.1
Mouth/teeth dental problems: Loose teeth	1.9	2.2	6.6	1.0	1.6	-0.5	1.6	0.7	2.6	-1.4
Emphysema/chronic bronchitis	0.3	0.3	0.6	0.6	0.5	-0.5	0.7	0.7	-0.8	0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	2.5	0.4	-0.7	1.1	0.0	1.3	-1.6	0.2
Neck or shoulder pain in last month	1.3	1.9	4.1	0.3	1.7	0.2	1.5	1.5	2.0	-1.2
Medication: Blood pressure	0.2	0.3	0.5	-0.7	0.5	-0.5	0.3	-0.5	0.2	-0.7
Angina (self-reported)	2.1	2.8	8.5	-2.9	-1.6	0.2	-1.9	-2.1	-0.1	0.4
Migraine (self-reported)	0.3	0.4	0.7	0.6	0.6	0.3	0.8	0.8	0.6	-0.4
Medication: Ibuprofen	0.3	0.4	1.0	-1.0	-0.6	-0.7	-0.5	-0.5	0.5	0.0
Medication: Allopurinol	0.7	1.0	2.7	-0.9	-0.5	-1.6	0.1	-1.4	1.0	-0.3
Medication: Omeprazole	0.9	1.1	2.5	1.0	1.6	-0.3	1.1	0.8	1.1	-0.8
Medication: Seretide 50 evohaler	0.3	0.3	1.0	0.0	0.2	-1.0	-0.0	-0.6	0.9	0.5
Mean time to correctly identify matches	0.8	1.5	2.8	0.4	1.6	-1.2	1.6	0.5	1.0	-1.7
Heart disease (mother)	0.7	0.8	2.2	-1.1	0.3	0.9	-0.6	1.5	-0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.1	0.9	-0.7	1.8	-0.3	1.3	-0.6	1.1
Whole body fat mass	1.2	5.0	9.0	1.9	2.5	-0.1	3.0	2.1	2.5	-2.5
Leg fat mass (right)	1.5	5.8	10.5	1.6	2.6	-0.5	3.2	1.9	2.8	-3.0
Arm predicted mass (right)	0.5	2.7	7.6	0.6	0.9	-0.7	1.8	0.9	2.3	-2.8
Pulse rate, automated reading	0.1	0.4	1.1	0.1	0.5	-1.1	0.3	0.9	0.6	0.3
Alcohol intake frequency.	0.4	1.0	3.3	1.8	0.5	0.2	1.5	-0.0	0.7	-0.6
Comparative height size at age 10	0.2	1.4	4.4	0.9	0.7	-0.9	1.5	0.7	0.6	-2.1
Number of full sisters	1.4	1.7	3.2	0.6	1.7	-1.4	1.8	-0.4	1.4	-1.2
Suffer from ‘nerves’	1.6	2.5	4.4	1.4	2.1	0.3	2.0	0.4	1.7	-2.0
Overall health rating	0.7	1.5	5.3	-0.7	1.1	-0.6	0.6	0.3	2.3	-1.7
Chest pain or discomfort	0.6	0.8	2.7	-1.6	1.0	0.2	0.4	0.3	0.9	-1.0
Had major operations	1.4	1.6	7.2	0.7	1.2	2.7	0.2	1.0	-0.9	0.6
Age at last live birth	0.5	0.7	2.3	-1.5	-0.1	-1.3	0.5	-0.5	0.2	-0.8
Family relationship satisfaction	0.1	0.1	0.3	-0.3	-0.0	0.1	-0.3	-0.6	0.3	0.3
Leg pain on walking	0.3	0.4	1.0	-0.3	-0.5	-0.7	-0.0	-0.6	1.0	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.8	-0.4	-0.7	0.2	-0.9	-0.7	-0.0	-0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	-0.6	-0.9	0.5	-1.3	-0.6	-1.3	1.3
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	4.8	-0.4	-2.2	0.5	-1.7	-1.4	-2.0	1.9
Medication: Aspirin	0.9	1.2	5.5	-1.2	0.0	0.1	-0.2	-0.5	2.4	-1.2
Supplements: Vitamin C	0.4	0.5	1.9	0.3	1.4	0.1	0.9	0.5	-0.4	-0.5
Knee pain experienced in last month	1.4	2.2	4.8	-1.1	-2.2	-2.1	-1.1	-1.7	0.5	0.6
Hypertension (Self-reported)	0.3	0.8	1.6	0.2	1.1	-0.1	1.3	1.2	0.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.1	1.0	0.6	1.1	-0.1	0.0	-0.9
Illnesses of father: Heart disease	1.6	2.2	6.0	-2.5	-1.6	-0.1	-1.8	-0.8	-1.3	1.0
Illnesses of siblings: Diabetes	1.8	2.2	5.6	-2.0	-2.4	-0.9	-1.2	-1.9	0.4	0.3
Smoking status: Previous	2.0	3.0	5.7	-1.2	-1.5	0.2	-2.4	-2.0	-2.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	1.0	0.0	-0.3	1.0	0.2	0.9	-1.2
Whole body fat-free mass	0.8	4.7	11.8	1.3	1.6	-1.0	2.6	1.0	2.8	-3.4
Leg fat-free mass (right)	0.9	5.0	10.1	2.2	1.9	-1.1	2.9	1.1	2.4	-3.2
Arm fat percentage (left)	1.1	4.3	7.4	1.8	2.4	-0.1	2.7	1.9	2.4	-2.0
Average weekly red wine intake	0.1	0.1	0.7	0.8	0.1	0.4	0.1	-0.2	-0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.8	-0.1	-0.7	0.8	-1.3	-0.3	-1.2	1.7
Mood swings	0.6	1.2	2.6	-1.0	-0.3	-1.6	-0.3	-1.1	1.6	-0.7
Loneliness, isolation	2.2	3.1	7.4	-2.7	-1.9	-0.2	-2.1	-1.2	-1.4	1.7
Long-standing illness, disability or infirmity	2.5	3.9	8.0	0.5	2.4	-0.6	2.0	1.2	2.8	-2.7
Ever had bowel cancer screening	0.2	0.3	0.6	0.8	-0.2	0.7	-0.3	0.2	-0.6	0.6
Diabetes diagnosed by doctor	0.4	0.7	2.0	-0.4	-1.2	-0.8	-0.1	-0.8	1.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.8	-0.4	0.3	-1.2	-0.1	-1.7	0.9	-0.0
Friendships satisfaction	1.8	2.2	6.1	-1.5	-1.7	-1.2	-1.5	-2.5	0.3	0.8
Qualifications: nursing, teaching	0.1	0.1	0.4	-0.6	-0.4	-0.2	-0.3	0.1	0.0	-0.2
Commuting to job workplace: Walk	2.4	2.6	5.8	1.0	0.8	-1.4	2.1	0.5	2.4	-2.2
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.8	-0.5	0.1	-0.4	-0.4	-0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.5	1.5	1.4	1.9	0.7	1.2	0.4	0.6
Medication for cholesterol	0.9	1.4	6.9	0.3	-2.6	-0.6	-1.1	-0.7	0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.9	-0.5	-0.9	-0.9	-1.1	-0.9	-0.8	1.4
Back pain experienced in last month	0.1	0.1	0.4	-0.1	0.5	-0.4	0.2	0.0	0.1	-0.7
Mineral and other dietary supplements	0.2	0.3	0.9	0.1	0.1	-0.8	0.2	-0.6	-0.1	1.0
Breast cancer (self-reported)	1.5	1.8	3.8	1.0	1.7	0.9	1.4	1.9	0.9	-1.1
Asthma (self-reported)	0.5	0.9	2.0	-0.0	1.2	1.1	0.8	1.4	0.1	-0.9
Osteoporosis (self-reported)	1.4	1.7	4.0	-1.4	-1.5	0.6	-2.0	-0.0	-0.3	1.8
Osteoarthritis (self-reported)	1.0	1.3	2.2	1.0	1.5	-0.5	1.1	1.2	0.8	-1.5
Medication: Aspirin	1.3	1.7	7.4	-1.4	0.2	0.4	-0.3	-0.3	2.7	-1.3
Medication: Gliclazide	0.3	0.3	0.6	-0.6	-0.5	0.8	-0.6	-0.3	-0.5	0.5
Illnesses of father: None of the above (group 1)	1.3	1.6	4.3	2.1	1.6	1.5	1.2	0.3	0.1	-0.8
Smoking status: Current	1.6	2.5	4.4	0.9	1.4	-1.3	1.8	2.1	1.9	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.9	-1.4	-0.8	-0.4	-0.2	-0.6	0.6	-0.8
Whole body water mass	0.8	4.4	11.3	1.2	1.5	-1.1	2.4	0.9	2.7	-3.4
Leg predicted mass (right)	0.9	5.0	10.4	2.2	1.8	-1.0	2.9	1.1	2.4	-3.2
Arm fat mass (left)	1.3	5.5	9.2	2.0	2.5	-0.3	3.0	2.1	2.8	-2.6
Number of self-reported non-cancer illnesses	2.5	4.4	8.2	0.5	2.5	0.7	2.3	2.2	2.4	-2.9
Average weekly champagne plus white wine intake	1.0	1.4	2.8	0.0	1.2	-1.7	1.0	-0.8	1.2	-1.5
Miserableness	0.6	1.0	2.1	0.5	1.4	0.9	1.1	0.8	0.3	-1.4
Guilty feelings	0.8	1.2	3.1	-0.4	-1.1	-1.2	-0.0	-1.6	1.8	0.2
Wears glasses or contact lenses	1.0	1.1	4.0	-0.1	0.2	1.7	-0.9	2.0	-0.4	0.1
Ever taken oral contraceptive pill	1.0	1.1	5.5	0.9	-0.3	-0.4	0.5	-1.0	2.3	-0.4
Hearing aid user	0.6	0.7	2.4	1.6	0.1	1.2	0.2	0.3	-0.8	0.6
Mother’s age at death	1.1	1.4	6.2	-0.2	0.5	1.6	-0.1	0.8	-2.5	0.2
Financial situation satisfaction	0.6	0.8	1.7	-1.0	-0.6	-1.3	-0.6	-1.1	0.7	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.6	-1.3	0.1	-0.5	0.1	0.1	-0.4	-0.3
Commuting to job workplace: Public transport	0.8	0.9	2.5	-0.7	0.2	0.3	0.4	-1.1	1.6	-1.4
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	-0.2	0.4	-0.5	0.5	-1.5	0.5	-1.2
Medication: Blood pressure	0.7	1.3	2.9	0.2	1.7	1.4	0.7	1.6	-1.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.8	-0.1	0.3	-1.9	0.8	-0.4	1.6	-0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	-0.9	-0.6	-0.2	-0.6	-0.6	-0.0	-0.1
High cholesterol (Self-reported)	0.8	1.5	5.2	-2.3	-1.1	-1.0	-1.0	-1.1	0.2	1.0
Medication: Bendroflumethiazide	0.3	0.5	1.7	0.1	1.3	-0.9	0.6	0.0	-0.2	-0.7
Medication: Paracetamol	0.9	1.3	3.9	0.8	1.3	-2.0	0.7	-1.5	0.3	-0.6
Medication: Lisinopril	1.9	2.4	4.0	1.4	1.3	-0.8	1.9	1.2	2.0	-1.8
Medication: Atorvastatin	0.3	0.4	1.7	-0.1	0.3	1.3	-0.3	0.8	-0.5	-0.0
Illnesses of father: High blood pressure	1.0	1.2	1.7	-1.1	-1.3	-0.4	-1.3	-1.2	-1.2	1.0
Alcohol drinker status: Never	0.4	0.5	2.0	0.7	0.1	1.4	0.2	0.8	0.2	-0.0
Ever smoked	0.2	0.4	0.7	0.3	0.8	0.9	-0.5	0.5	-0.8	0.4
Basal metabolic rate	1.0	5.4	12.5	1.5	1.9	-1.1	2.9	1.2	3.0	-3.5
Leg fat percentage (left)	0.8	2.8	6.3	0.5	1.6	-0.4	2.1	1.4	2.5	-2.0
Arm fat-free mass (left)	0.6	3.0	7.9	0.5	1.1	-0.9	1.9	0.9	2.5	-2.8
Number of operations (self-reported)	0.6	0.9	2.5	0.7	1.5	0.7	0.8	1.6	0.1	-0.4
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.6	-0.4	-0.1	0.6	-0.3	0.5	0.3
Irritability	1.2	2.0	5.4	-2.3	-1.0	-1.1	-1.2	-2.0	-0.0	0.9
Risk taking	1.8	2.6	5.8	-2.0	-1.9	-2.4	-0.9	-1.6	1.1	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.8	-0.3	-0.9	-0.4	-0.1	-0.6	0.2	0.4
Fractured/broken bones in last 5 years	1.9	2.4	6.2	-2.5	-0.1	-1.8	-0.2	-0.7	2.5	-1.0
Age started oral contraceptive pill	1.0	1.2	3.0	0.2	-0.4	1.4	-0.3	1.5	-1.7	1.1
Diastolic blood pressure, automated reading	0.1	0.3	1.2	-0.1	0.1	0.0	0.6	1.1	0.5	-0.6
Ever depressed for a whole week	0.2	0.3	1.3	0.5	-0.1	0.1	0.1	1.1	0.1	0.5
Unable to work because of sickness or disability	1.3	1.7	6.9	0.3	1.0	-0.8	1.1	0.5	2.6	-1.4
Commuting to job workplace: Cycle	0.6	0.8	3.5	0.8	0.1	-1.9	0.8	-0.5	0.6	-0.3
Myopia	0.4	0.6	1.5	1.0	0.7	1.1	-0.1	1.2	-0.3	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.9	0.5	-0.9	0.1	-0.8	-1.0	-0.2	0.7
Cholesterol lowering medication	0.6	0.8	2.5	-1.6	1.0	0.4	0.1	1.4	0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	0.6	1.5	0.2	1.0	1.1	0.7	-0.6
Pain experienced in last month	1.2	2.0	5.1	0.1	-1.4	0.4	-1.5	-0.7	-2.3	1.9
Supplements: Calcium	0.5	0.6	1.2	-1.1	-0.6	0.6	-1.0	-0.3	0.1	0.9
Basal cell carcinoma (self-reported)	0.9	1.1	3.6	-0.0	-0.9	-1.1	-1.1	-1.0	-0.3	1.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.9	-1.0	0.8	2.0	0.2	-0.2	-0.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	4.1	1.2	0.6	2.0	0.4	1.6	-1.4	-0.2
Heart disease (siblings)	1.0	1.3	3.4	-1.9	-1.1	0.4	-1.3	-0.7	-0.9	1.0
Alcohol drinker status: Previous	0.7	0.7	2.0	1.4	0.0	-1.2	0.6	-1.1	0.2	-0.1
Pack years of smoking	0.5	0.8	1.7	0.1	1.3	0.3	0.3	1.3	1.3	-0.7
Impedance of whole body	0.3	1.3	3.8	0.6	0.6	1.4	-0.1	0.2	-2.0	1.6
Leg fat mass (left)	1.3	4.9	8.5	1.4	2.2	-0.7	2.9	1.8	2.8	-2.8
Arm predicted mass (left)	0.7	3.6	9.3	0.5	1.1	-0.9	2.0	0.9	2.9	-3.0