TWAS hub - C9orf68

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.1144	0.0262	1.9e-15	0.104	0.087	0.096	NA	0.106	1.3e-20	2.4e-17	5.1e-19	NA	6.1e-21
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0868	0.0341	2.7e-04	0.037	0.037	0.028	NA	0.030	4.4e-05	4.2e-05	4.0e-04	NA	2.5e-04
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1680	0.0550	1.1e-05	0.170	0.111	0.149	NA	0.144	5.3e-10	6.6e-07	7.2e-09	NA	1.2e-08
4	TCGA	Brain Lower Grade Glioma	0.1779	0.0420	9.0e-11	0.054	0.117	0.119	NA	0.119	9.6e-07	3.6e-13	1.9e-13	NA	2.2e-13
5	TCGA	Pheochromocytoma and Paraganglioma	0.1650	0.0810	3.9e-03	0.149	0.105	0.153	NA	0.151	1.6e-06	6.1e-05	1.2e-06	NA	1.4e-06
6	TCGA	Prostate Adenocarcinoma	0.1744	0.0441	6.9e-13	0.092	0.140	0.148	NA	0.124	7.1e-10	1.7e-14	3.0e-15	NA	6.1e-13
7	TCGA	Thyroid Carcinoma	0.4350	0.0610	0.0e+00	0.328	0.321	0.345	NA	0.341	1.1e-32	6.8e-32	9.3e-35	NA	3.0e-34

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Red Count	7.4	71.1	99.8	9.4	8.1	8.6	6.5	10.0	6.3	9.3
Long-standing illness, disability or infirmity	4.6	7.0	9.2	2.6	2.8	2.9	1.3	3.0	2.7	2.8
Pain all over the body in last month	3.8	4.1	6.6	1.8	2.6	2.2	0.9	1.7	2.3	2.3
Number of self-reported non-cancer illnesses	3.7	6.4	9.5	2.5	3.1	2.5	2.1	2.7	1.5	3.0
Medication: Lisinopril	3.7	4.7	7.5	2.2	2.4	2.1	1.7	2.7	1.6	2.3
Waist circumference	3.1	11.4	17.7	3.4	2.2	3.5	4.2	3.0	3.8	3.2
Alzheimer’s Disease (including proxy)	3.0	4.3	6.4	2.0	1.9	2.0	1.3	2.4	2.1	2.5
Reaction Time	3.0	5.8	9.2	3.0	0.8	3.0	1.8	2.6	2.9	1.8
Hand grip strength (right)	3.0	8.2	12.5	-2.9	-1.7	-3.3	-3.5	-2.8	-3.1	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.7	11.9	3.5	1.1	3.1	2.7	2.9	2.2	2.0
Headache pain in last month	3.0	5.2	8.8	2.3	1.4	2.7	3.0	2.3	1.9	2.1
Medication: Ventolin 100micrograms inhaler	3.0	3.9	7.0	1.9	1.4	2.1	2.4	1.9	0.8	2.6
Worry too long after embarrassment	3.0	5.0	10.4	2.0	1.2	2.6	3.2	2.2	2.0	1.9
Body Mass Index (BMI) (2010)	2.9	4.0	6.2	2.4	2.5	2.2	1.0	2.3	1.2	1.9
Falls in the last year	2.9	3.9	6.9	2.1	1.3	2.2	1.6	1.9	2.6	1.9
Number of full sisters	2.8	3.4	5.7	2.1	0.7	2.0	2.4	1.7	1.9	1.8
Hand grip strength (left)	2.7	7.2	10.0	-2.7	-1.5	-3.1	-3.2	-2.6	-3.1	-2.1
Medication: Co-codamol	2.6	3.0	5.0	1.7	1.4	2.2	1.3	1.8	2.0	1.6
Osteoporosis (self-reported)	2.6	3.2	9.4	-1.8	-1.1	-2.1	-3.1	-1.3	-1.1	-1.2
Bipolar Disorder (2011)	2.5	2.4	7.9	1.0	2.8	1.4	-0.2	0.0	2.5	0.0
Ever used hormone-replacement therapy (HRT)	2.5	3.2	4.7	-1.8	-1.1	-2.0	-2.2	-1.6	-1.9	-1.6
Mean time to correctly identify matches	2.5	4.8	9.9	2.8	0.9	2.5	0.9	2.3	3.1	1.7
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	4.2	-2.0	-1.7	-1.8	-1.1	-2.0	-1.3	-2.0
Bipolar Disorder (2018)	2.4	3.8	8.9	2.0	1.0	2.2	1.9	1.8	3.0	1.1
Nervous feelings	2.4	4.4	6.0	2.2	2.2	2.3	2.1	2.4	0.6	2.3
Unable to work because of sickness or disability	2.4	3.2	5.0	1.7	1.7	1.9	0.8	2.2	2.1	1.7
Loneliness, isolation	2.3	3.1	5.6	-2.0	-0.2	-2.1	-1.7	-1.8	-2.4	-1.2
Waist Hip Ratio (WHR)	2.2	9.7	13.7	3.7	2.0	3.5	3.0	3.7	2.2	3.3
Taking other prescription medications	2.2	3.4	4.8	1.9	1.1	2.0	2.2	2.0	1.3	2.1
Exposure to tobacco smoke outside home	2.2	3.0	10.1	1.6	0.8	1.8	3.2	1.1	1.3	1.2
Breast Cancer	2.1	5.0	10.0	-2.1	-3.2	-2.2	-0.6	-2.3	-2.5	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.3	2.1	1.5	1.7	2.1	1.5	0.5	1.6
Commuting to job workplace: Walk	2.1	2.3	3.9	1.9	0.7	2.0	1.5	1.8	1.1	1.2
Depression (Nagel 2018)	2.0	3.0	5.5	2.0	2.4	1.9	0.8	1.9	0.8	1.6
Leg fat-free mass (left)	2.0	10.6	17.4	3.4	2.2	3.7	4.2	3.0	2.6	3.2
Leg predicted mass (left)	2.0	10.7	17.4	3.5	2.2	3.7	4.2	3.1	2.6	3.2
Mouth/teeth dental problems: Loose teeth	2.0	2.3	4.0	1.6	1.1	2.0	1.3	1.9	1.3	1.3
Leg fat mass (right)	2.0	7.7	15.2	2.8	1.4	2.7	3.9	2.3	3.3	2.4
Current tobacco smoking	1.9	3.1	4.0	1.8	1.8	1.7	1.6	1.9	1.3	2.0
Hayfever, allergic rhinitis or eczema	1.9	4.0	6.5	1.8	2.5	2.0	2.0	1.9	1.7	1.9
Had menopause	1.9	2.3	5.8	-1.4	-0.4	-1.9	-2.4	-1.2	-1.7	-0.7
Weight	1.9	9.4	17.5	3.0	2.1	3.2	4.2	2.7	3.1	3.0
Basal cell carcinoma (self-reported)	1.9	2.2	3.8	-1.7	-1.4	-1.7	-0.9	-2.0	-0.6	-1.7
Heel T-Score	1.8	14.0	16.4	4.0	3.3	4.0	3.7	3.9	3.2	3.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	6.4	2.5	1.3	2.4	1.9	2.4	1.8	1.7
Smoking status: Previous	1.8	2.7	5.0	-1.7	-0.5	-1.4	-2.2	-1.7	-1.8	-1.7
Medication for cholesterol	1.8	2.8	6.1	-1.6	-2.5	-1.6	-0.2	-1.7	-1.0	-2.1
Pain experienced in last month	1.8	2.9	4.6	-1.4	-1.0	-2.1	-1.8	-1.7	-2.1	-1.5
Leg fat mass (left)	1.8	7.1	12.7	2.5	1.6	2.5	3.6	2.2	3.4	2.3
Loud music exposure frequency	1.7	1.9	3.5	-1.9	-1.2	-1.1	-0.7	-1.8	-0.6	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	3.2	-1.8	-1.0	-1.4	-1.4	-1.7	-0.2	-1.6
Basal metabolic rate	1.7	9.6	14.1	3.1	2.3	3.5	3.8	2.8	2.8	3.1
High blood pressure (mother)	1.6	2.2	6.3	1.6	-0.9	1.5	2.5	1.3	0.7	1.1
Had other major operations	1.6	2.0	4.9	1.0	2.2	1.2	-0.0	1.5	0.4	2.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.4	1.2	2.1	1.4	1.0	1.7	1.4	1.2
Leg fat-free mass (right)	1.6	8.8	14.7	3.1	2.2	3.3	3.8	2.6	2.5	2.9
Leg predicted mass (right)	1.6	8.7	14.2	3.1	2.2	3.3	3.8	2.7	2.5	2.9
Arm fat mass (left)	1.6	6.5	13.5	2.4	1.6	2.4	3.7	2.2	2.9	2.3
Ulcerative Colitis	1.5	2.1	6.4	0.5	2.5	0.7	-1.1	1.2	2.0	1.0
Blood White Count	1.5	11.2	24.0	2.9	4.9	3.0	1.6	2.9	3.9	3.2
Chronic bronchitis/emphysema (father)	1.5	1.8	4.2	-1.4	-0.0	-1.6	-2.1	-1.1	-0.9	-1.4
Trunk fat mass	1.5	6.2	13.6	2.3	1.5	2.3	3.7	2.0	2.9	2.3
Arm fat mass (right)	1.5	6.3	13.7	2.3	1.6	2.4	3.7	2.1	2.9	2.1
Exposure to tobacco smoke at home	1.5	1.7	4.5	1.1	0.6	1.4	2.1	1.0	1.2	1.3
Glaucoma (self-reported)	1.5	1.8	3.0	1.7	1.0	1.6	1.2	1.3	1.2	1.1
Health satisfaction	1.5	1.9	3.3	-1.8	-1.7	-1.1	-0.2	-1.2	-1.1	-1.8
Eye problems/disorders: None of the above	1.5	1.7	3.8	-1.7	-1.2	-1.2	0.2	-1.9	0.1	-1.6
Whole body fat-free mass	1.5	8.8	12.0	3.1	2.2	3.5	3.4	2.7	2.5	3.1
Whole body water mass	1.5	8.3	11.3	3.0	2.2	3.4	3.3	2.7	2.5	3.0
Supplements: Calcium	1.5	1.6	2.9	-1.7	-1.1	-1.3	-0.8	-1.4	-1.1	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.4	1.7	1.3	1.5	1.5	1.9	0.6	1.4
Trunk predicted mass	1.4	7.8	10.9	2.9	2.2	3.3	2.9	2.6	2.5	3.0
Whole body fat mass	1.4	5.9	12.8	2.2	1.5	2.2	3.6	2.0	2.8	2.2
Hearing difficulty/problems: Yes	1.3	1.9	3.9	1.7	1.1	0.8	1.4	1.7	0.3	2.0
Average weekly fortified wine intake	1.3	1.5	3.0	-1.3	-1.7	-1.2	0.1	-1.6	-0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.6	1.3	1.6	1.4	1.5	1.4	0.4	1.2
Financial difficulties in last 2 years	1.3	1.7	4.5	1.3	2.1	1.3	0.6	1.6	0.6	1.1
Arm fat percentage (right)	1.3	5.3	11.2	2.0	1.5	2.0	3.3	1.9	2.9	1.9
Trunk fat-free mass	1.3	7.7	10.9	2.8	2.2	3.3	3.0	2.6	2.5	3.0
Tense / ‘highly strung’	1.3	2.1	4.1	-1.5	-1.1	-1.2	-0.6	-1.5	-2.0	-1.7
Leg fat percentage (right)	1.3	4.7	9.8	2.0	0.8	1.8	3.1	1.8	2.9	1.8
Neck or shoulder pain in last month	1.3	1.9	3.9	1.2	1.3	1.9	1.1	2.0	0.4	1.0
Suffer from ‘nerves’	1.3	2.1	3.7	1.5	0.7	1.7	1.9	1.8	0.3	1.4
Smoking status: Current	1.3	2.1	2.5	1.5	1.6	1.4	1.6	1.4	1.1	1.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.0	0.7	0.5	1.0	2.0	0.5	2.0	1.1
Arm predicted mass (left)	1.3	6.4	8.4	2.5	1.8	2.9	2.8	2.4	2.5	2.7
Bipolar Disorder or Schizophrenia	1.2	2.9	4.8	1.8	1.3	2.2	1.0	2.0	2.1	1.0
Alzheimer’s Disease (in father)	1.2	1.3	2.2	0.8	1.1	1.4	1.2	0.7	1.5	1.0
Ulcerative Colitis (UC)	1.2	2.2	7.9	-0.2	2.4	-0.2	-2.8	0.4	1.2	0.6
Allergy	1.2	2.7	7.1	-1.0	-2.7	-1.2	-2.1	-1.0	-0.9	-1.8
Medication: Ramipril	1.2	1.5	3.0	1.1	1.7	1.6	-0.2	1.0	1.1	1.3
Time employed in main current job	1.2	1.4	3.2	-1.0	-1.1	-0.7	-1.8	-1.0	0.4	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.2	1.3	1.2	0.9	0.7	1.1	1.0	1.8
Average weekly champagne plus white wine intake	1.2	1.6	2.7	1.5	0.7	1.6	0.9	1.2	1.4	1.2
Rheumatoid Arthritis	1.1	1.5	5.0	-0.9	-0.9	-1.3	-1.1	-0.6	-2.2	-0.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.7	1.2	1.6	1.1	1.3	1.2	0.7	1.3
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.9	0.5	1.1	1.3	0.5	1.0	2.2	0.9
Body mass index (BMI)	1.1	4.5	10.0	1.8	1.2	2.0	3.2	1.7	2.7	1.7
Hip circumference	1.1	4.7	9.6	1.9	1.5	2.1	3.1	1.4	2.7	2.0
Pulse rate	1.1	1.9	2.5	1.2	1.6	1.5	1.2	1.1	1.6	1.2
Medication: Omeprazole	1.1	1.3	3.7	0.7	0.6	0.9	1.9	0.5	1.7	0.8
Arm fat percentage (left)	1.1	4.4	10.5	1.8	1.4	1.8	3.2	1.7	2.6	1.7
Osteoarthritis (self-reported)	1.1	1.5	2.0	1.2	1.2	1.4	1.2	1.0	1.1	1.4
Pain type(s) experienced in last month: Hip pain	1.1	1.3	4.6	0.5	0.2	1.2	1.6	0.6	2.1	0.2
Arm fat-free mass (left)	1.1	5.6	7.4	2.3	1.8	2.7	2.7	2.2	2.2	2.6
Schizophrenia (2014)	1.0	2.1	4.2	1.4	1.4	2.1	0.6	1.5	1.7	0.9
Neuroticism	1.0	2.4	3.9	1.6	1.2	1.4	2.0	1.8	1.1	1.6
Heart attack	1.0	1.2	2.2	1.2	1.3	0.9	0.8	1.3	0.2	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.0	1.2	1.4	1.5	1.2	1.7	-0.2	1.2
Asthma	1.0	2.0	4.8	0.6	2.1	0.9	2.2	0.5	0.3	1.9
Hair/balding pattern: Pattern 4	1.0	2.5	3.8	1.8	1.9	1.9	0.7	1.5	1.2	1.7
Arm fat-free mass (right)	1.0	5.2	7.1	2.3	1.7	2.6	2.7	2.1	1.9	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.4	-0.9	-1.0	-1.6	-0.7	-0.8	-1.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	5.9	-0.9	-2.4	-1.2	0.5	-0.6	0.3	-1.4
Medication: Aspirin	1.0	1.3	3.6	0.5	1.9	0.9	-0.1	1.2	1.2	1.2
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	1.4	0.6	1.5	0.6	1.3	0.6	1.1
Leg fat percentage (left)	1.0	3.5	8.5	1.6	0.8	1.4	2.5	1.4	2.9	1.5
Fractured/broken bones in last 5 years	1.0	1.2	2.9	0.7	1.0	1.0	-0.9	1.3	1.7	0.9
Alzheimer’s Disease (in mother)	0.9	1.1	2.0	0.8	0.8	0.8	-0.3	1.3	1.3	1.4
Irritable Bowel Disease (IBD)	0.9	2.1	8.4	-0.9	1.8	-0.7	-2.9	-0.6	1.2	0.1
Blood Platelet Count	0.9	10.2	30.5	3.3	0.7	2.0	5.5	4.2	-1.1	2.5
Serious illness, injury or assault to yourself	0.9	1.0	1.8	1.2	0.9	1.2	0.7	1.1	0.1	1.3
Multivitamins +/- minerals	0.9	1.2	2.3	0.8	0.7	1.5	1.2	0.8	1.3	1.0
Lung cancer (father)	0.9	1.0	1.7	-1.2	-0.8	-1.3	-0.7	-1.2	-0.7	-1.1
High blood pressure (siblings)	0.9	1.3	3.2	0.8	1.2	1.1	-0.6	1.2	1.8	0.9
Body fat percentage	0.9	3.4	8.7	1.6	0.9	1.4	3.0	1.4	2.4	1.5
Arm predicted mass (right)	0.9	4.8	6.7	2.2	1.6	2.5	2.6	2.0	1.8	2.4
Overall health rating	0.9	1.9	3.5	1.3	1.7	1.6	0.7	1.9	1.1	1.1
Allergy or Eczema	0.8	2.2	5.7	1.2	2.4	1.4	0.9	1.3	1.6	1.2
Number of treatments/medications taken	0.8	1.4	2.3	0.9	1.4	1.5	1.2	1.0	0.9	1.3
Trunk fat percentage	0.8	3.2	8.4	1.5	1.0	1.4	2.9	1.3	2.2	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	-1.1	-1.2	-0.7	-0.4	-0.9	-0.9	-1.3
Qualifications: College or University degree	0.8	2.5	5.7	1.6	2.1	1.6	0.9	1.3	0.5	2.4
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.7	-1.1	-0.1	-1.3	-1.3	-1.1	0.5	-0.8
Illnesses of father: Heart disease	0.8	1.1	3.6	-1.2	0.8	-1.2	-1.9	-0.8	-0.4	0.1
Ever had bowel cancer screening	0.8	1.0	1.7	-0.9	-1.3	-1.0	-0.5	-1.0	-0.3	-1.3
Breast cancer (self-reported)	0.8	1.0	1.4	1.2	1.0	1.2	0.9	1.1	-0.5	0.9
Asthma (self-reported)	0.8	1.5	3.8	0.5	1.9	0.6	1.7	0.2	0.2	1.7
Heart disease (siblings)	0.8	0.9	4.2	-0.9	-0.0	-0.7	-2.0	-0.7	0.1	-0.7
Mean Putamen Volume	0.7	0.8	1.1	1.0	1.1	0.9	-0.4	1.1	0.8	1.0
BMI	0.7	3.9	7.2	1.7	0.7	2.2	2.6	1.7	2.7	1.5
Cardiovascular Disease	0.7	2.2	3.5	1.4	1.4	1.9	1.3	1.6	1.4	1.5
Diabetes (mother)	0.7	0.9	2.7	1.2	0.2	0.7	0.1	1.6	-0.5	1.1
Illnesses of siblings	0.7	0.9	2.3	-0.5	-1.0	-0.9	1.5	-0.4	-1.4	-0.4
Neuroticism score	0.7	1.5	6.4	0.9	0.2	1.1	2.5	1.1	0.5	0.8
Pulse wave Arterial Stiffness index	0.7	0.9	1.5	0.9	1.2	1.2	0.4	0.8	0.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.6	1.1	0.5	0.5	1.6	1.1	-0.9	0.9
Birth weight of first child	0.7	1.2	2.6	-1.2	0.0	-1.6	-1.1	-1.0	-1.4	-0.7
Pulse wave peak to peak time	0.7	0.8	1.4	-0.9	-1.2	-1.1	-0.2	-0.9	-0.5	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	-1.3	-0.2	-0.9	-1.0	-1.1	-0.7	-1.0
Friendships satisfaction	0.7	0.9	2.0	-1.1	-1.4	-1.0	-0.7	-0.7	-0.6	-0.9
Eye problems/disorders: Cataract	0.7	0.8	1.4	-0.7	-0.9	-0.7	-1.0	-0.3	-1.2	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.7	-0.9	-0.3	-0.9	-1.2	-0.8	-0.7	-1.3
Wears glasses or contact lenses	0.7	0.8	2.1	-0.7	1.4	-0.6	-1.2	-0.7	0.6	0.4
Illnesses of father: High blood pressure	0.7	0.9	1.6	-1.2	-0.7	-0.9	-0.7	-1.3	0.0	-1.1
Worry (Nagel 2018)	0.6	1.3	2.1	1.4	0.7	1.2	1.4	1.4	-0.0	1.0
Primary Biliary Cirrhosis	0.6	0.9	1.4	0.9	1.1	1.1	0.6	1.0	0.4	1.2
Respiratory disease	0.6	1.4	3.1	0.8	1.3	1.1	1.7	0.4	0.4	1.6
Supplements: Zinc	0.6	0.6	1.4	0.9	0.7	1.1	1.2	0.4	0.5	0.4
Pack years adult smoking proportion	0.6	1.0	1.5	0.8	1.0	0.8	0.9	1.2	1.1	1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.5	-0.5	-1.1	0.2	1.2	-0.6	-0.3	-0.8
Past tobacco smoking	0.6	1.1	2.2	1.1	-0.2	0.8	1.5	1.1	1.2	1.0
Standing height	0.6	6.3	9.5	2.9	1.8	2.9	2.7	2.4	1.1	3.1
Breastfed as a baby	0.6	0.7	1.0	-1.0	-0.6	-0.7	-1.0	-0.8	-1.0	-0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	-0.6	-1.2	-0.3	0.4	-0.8	-1.2	-0.9
Age at first live birth	0.6	1.0	3.7	-0.8	-0.3	-0.8	-1.9	-0.7	-1.0	-0.7
Medication: Blood pressure	0.6	1.1	2.0	0.9	1.0	1.3	0.7	0.9	1.4	0.7
Angina (self-reported)	0.6	0.8	1.4	-1.1	0.0	-0.8	-1.1	-1.2	0.5	-0.8
Comparative height size at age 10	0.6	3.3	5.1	2.2	1.6	1.8	1.5	1.6	1.4	2.3
Chest pain or discomfort	0.6	0.8	1.3	0.8	1.0	1.0	0.3	1.0	0.9	1.1
Age at last live birth	0.6	0.9	1.4	1.2	1.0	0.9	0.1	1.2	0.6	1.0
Medication: Aspirin	0.6	0.8	2.2	0.3	1.5	0.7	0.0	0.9	1.0	0.8
Knee pain experienced in last month	0.6	0.9	2.4	-0.6	-1.6	-0.3	-0.2	-0.2	1.2	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	0.8	0.4	0.8	1.3	0.2	1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.4	0.8	1.8	0.5	-0.7	1.3	1.3	1.1
Commuting to job workplace: Public transport	0.6	0.7	1.3	0.9	-0.2	1.1	1.0	0.7	0.1	1.1
Medication: Blood pressure	0.6	1.1	3.1	1.0	1.8	0.9	0.1	1.2	0.2	1.3
Number of operations (self-reported)	0.6	0.9	2.2	0.7	1.4	0.6	0.5	0.9	0.3	1.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.8	0.9	1.3	0.7	0.3	1.0	-0.1	1.2
Crohns Disease (2017)	0.5	1.2	2.2	-1.3	0.2	-0.9	-1.5	-1.4	0.9	-0.7
HDL Cholesterol	0.5	0.9	1.4	-1.2	-0.8	-1.0	-0.7	-1.1	-0.5	-1.0
Sensitivity / hurt feelings	0.5	0.8	2.6	0.4	0.6	0.8	1.6	1.1	-0.3	0.9
Medication: Metformin	0.5	0.7	3.0	0.4	0.2	0.8	0.4	0.9	1.7	0.1
Diabetes (father)	0.5	0.6	1.0	0.8	0.8	0.4	0.4	0.8	0.8	1.0
Relative age voice broke	0.5	0.8	1.2	-1.1	-0.8	-0.8	-0.6	-0.7	-0.9	-1.1
Medication: Atenolol	0.5	0.7	3.1	0.4	0.9	0.6	0.1	0.1	1.8	0.7
Sitting height	0.5	3.2	5.5	2.1	1.2	1.9	2.2	1.4	0.9	2.4
Hearing difficulty/problems with background noise	0.5	0.9	1.8	-1.0	-0.2	-1.1	-1.1	-0.6	-0.6	-1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.4	-0.6	-1.0	-0.5	0.5	-0.6	-1.2	-0.9
Father’s age at death	0.5	0.6	1.1	0.8	0.7	1.1	0.7	0.7	1.0	0.6
Depression (self-reported)	0.5	0.6	1.5	-0.6	-0.0	-1.0	-0.8	-0.4	-1.2	-0.6
Length of working week for main job	0.5	0.5	1.9	0.1	-0.2	0.7	0.6	0.7	1.4	0.4
Medication: Paracetamol	0.5	0.8	1.8	0.8	0.7	1.0	0.1	1.0	1.3	0.6
Illnesses of siblings: Diabetes	0.5	0.6	2.3	-0.1	0.4	0.1	-1.3	-0.1	1.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.8	0.9	0.1	1.1	2.0	0.8	-0.7	0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	0.5	-1.2	0.5	1.2	0.3	-0.6	-0.4
Miserableness	0.5	0.9	3.5	0.9	-0.2	0.7	1.9	0.7	0.7	0.7
Medication: Bendroflumethiazide	0.5	0.8	2.1	0.7	0.7	1.1	0.1	0.8	1.5	0.7
Medication: Paracetamol	0.5	0.8	1.4	1.0	0.5	1.1	0.3	1.0	1.2	0.7
Alcohol drinker status: Never	0.5	0.6	0.9	-0.9	-0.7	-0.9	0.7	-0.9	-0.9	-0.3
Major Depression (MDD)	0.4	0.5	1.5	-0.3	-1.2	-0.3	-0.9	-0.5	-0.2	-0.8
Ovarian Cancer	0.4	0.5	0.8	0.8	0.8	0.9	0.4	0.7	0.8	0.5
Prostate Cancer	0.4	0.5	1.4	-0.3	-0.4	-0.0	-1.2	-0.8	-0.0	-1.1
Age at First Birth	0.4	0.6	2.5	0.4	1.6	-0.2	-0.1	0.1	1.1	0.5
Coronary Artery Disease (CAD)	0.4	0.5	0.9	-0.7	-0.4	-1.0	-0.4	-0.9	-0.4	-0.8
HbA1C	0.4	0.5	1.2	-0.3	-1.1	-0.3	0.8	-0.2	-1.0	0.1
Lupus	0.4	0.6	1.7	0.3	0.3	0.9	0.8	1.1	1.3	-0.1
Smoking Status	0.4	1.0	2.8	0.9	1.7	0.7	0.4	0.5	-0.0	1.5
Chronotype (morning person)	0.4	0.9	1.6	-1.1	-0.4	-1.2	0.2	-1.2	-1.2	-0.7
Stomach or abdominal pain in last month	0.4	0.5	2.2	0.3	-0.8	0.5	1.5	-0.2	0.5	-0.1
Impedance of leg (left)	0.4	1.8	2.8	-1.2	-1.3	-1.7	-1.7	-1.1	-1.4	-1.0
Number of live births	0.4	0.6	1.8	-0.5	-1.3	-0.3	-0.3	0.0	-1.3	-0.6
Medication: Lansoprazole	0.4	0.4	2.0	0.5	0.4	0.4	1.4	0.5	0.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.5	1.6	1.1	1.2	0.3	1.6	-0.2	1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-0.9	-1.0	-0.7	-0.8	-1.1	-0.1	-0.5
Comparative body size at age 10	0.4	1.0	2.0	1.0	0.2	1.4	1.2	0.8	0.6	1.1
Wheeze or whistling in the chest in last year	0.4	0.8	4.4	0.3	0.6	0.5	2.1	0.0	0.2	0.6
Medication: Ibuprofen	0.4	0.5	1.1	-0.8	-0.8	-0.4	-0.4	-0.7	-0.3	-1.1
Supplements: Vitamin C	0.4	0.4	1.8	0.3	-0.1	0.5	1.3	-0.3	0.8	0.2
Financial situation satisfaction	0.4	0.5	1.1	-0.9	-0.6	-0.4	0.1	-0.7	-0.6	-1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.1	0.5	0.2	0.3	0.8	0.1	1.4	0.7
Cholesterol lowering medication	0.4	0.6	1.6	0.5	1.2	-0.0	-0.6	0.4	0.8	1.3
Pack years of smoking	0.4	0.5	1.1	0.4	1.0	0.4	0.3	0.8	0.8	0.9
Schizophrenia (2018)	0.3	0.6	1.2	0.8	0.9	1.1	-0.2	1.1	0.2	0.4
Crohns Disease (2012)	0.3	0.5	1.2	-0.5	0.7	-0.3	-1.1	-0.4	1.1	-0.1
LDL Cholesterol	0.3	0.5	0.9	0.8	1.0	0.6	0.7	0.9	0.7	0.5
Height	0.3	5.9	10.9	2.8	2.4	2.8	1.1	2.7	1.0	3.3
Systolic Blood Pressure	0.3	1.4	2.7	1.3	1.6	1.1	-0.1	1.1	0.4	1.5
Hypothyroidism (self reported)	0.3	0.6	1.6	0.7	0.3	0.9	1.2	0.8	0.3	0.6
Lung FVC	0.3	1.3	6.4	-0.3	1.4	-0.8	-2.5	0.0	-0.6	-0.4
Angina	0.3	0.4	0.8	-0.9	0.0	-0.5	-0.8	-0.9	0.3	-0.6
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	-0.5	-0.9	-0.6	-0.3	-0.6	-0.4	-0.7
Medication: Simvastatin	0.3	0.5	1.8	0.4	0.6	0.7	0.4	0.5	1.3	0.6
Worrier / anxious feelings	0.3	0.5	1.9	0.6	-0.0	0.7	1.4	0.7	0.5	0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.6	-0.3	-0.8	-0.5	0.1	-0.6	-1.6	-0.5
Medication: Cholesterol lowering	0.3	0.5	1.1	-0.8	-0.1	-0.4	-0.6	-0.7	0.7	-1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.2	-0.2	-0.8	-0.7	-0.2	-0.2	-1.5	0.1
Gout (self-reported)	0.3	0.4	0.6	-0.6	-0.7	-0.8	-0.4	-0.8	-0.2	-0.7
Number of full brothers	0.3	0.4	2.0	-0.3	0.1	-0.4	-1.4	-0.3	0.0	-0.4
Number of children fathered	0.3	0.4	0.7	-0.4	0.8	-0.8	-0.8	-0.6	0.2	0.1
Heart disease (mother)	0.3	0.4	1.0	-0.5	0.1	-0.8	-0.7	-0.3	-1.0	0.1
Alcohol intake frequency.	0.3	0.6	1.9	0.8	-0.6	0.6	1.4	0.8	-0.3	0.6
Hypertension (Self-reported)	0.3	0.8	1.3	1.0	0.8	1.1	0.6	1.1	0.6	0.8
Qualifications: nursing, teaching	0.3	0.5	2.0	0.0	1.4	0.8	-0.2	-0.0	0.7	0.4
Back pain experienced in last month	0.3	0.4	0.8	0.4	0.8	0.9	0.4	0.5	0.7	0.5
Mineral and other dietary supplements	0.3	0.4	1.6	-0.0	-1.3	-0.7	-0.3	-0.1	-0.7	-0.6
Guilty feelings	0.3	0.4	1.2	-0.5	-0.8	-0.4	1.1	0.1	0.8	-0.4
Ever taken oral contraceptive pill	0.3	0.4	1.7	0.3	-0.5	0.4	1.3	0.3	0.4	-0.1
High cholesterol (Self-reported)	0.3	0.5	0.9	-0.7	-0.1	-0.9	-0.9	-0.7	-0.5	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	-0.4	-0.7	0.0	0.3	-0.5	0.5	-0.9
Age started oral contraceptive pill	0.3	0.3	0.8	-0.5	0.5	-0.9	-0.7	-0.6	-0.4	-0.0
Commuting to job workplace: Cycle	0.3	0.4	1.7	0.4	-0.5	0.5	1.3	0.4	-0.5	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.3	-0.9	-1.1	-1.0	-0.3	-0.9	-0.9	-0.8
Impedance of whole body	0.3	1.7	4.1	-1.0	-1.3	-1.6	-1.1	-0.9	-2.0	-1.0
Neuroticism (Nagel 2018)	0.2	0.4	0.9	0.7	0.5	0.7	0.8	0.9	0.0	0.6
Fasting Glucose	0.2	0.2	1.1	-0.1	0.0	0.3	-0.2	0.4	1.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	0.4	0.5	0.8	0.6	0.1	0.4	0.2
Average weekly spirits intake	0.2	0.2	0.5	-0.1	-0.6	-0.1	0.5	-0.4	0.7	-0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.2	-0.6	-0.5	-0.3	-0.5	-0.4	-0.1
Medication for hormone replacement therapy	0.2	0.3	0.8	0.2	0.9	0.3	-0.7	0.2	0.3	0.5
Impedance of leg (right)	0.2	0.8	1.9	-0.5	-1.3	-1.0	-0.9	-0.4	-1.4	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.5	-0.7	-0.6	0.6	-0.5	-0.8	-0.4
Maternal smoking around birth	0.2	0.3	0.6	-0.7	-0.8	-0.8	-0.0	0.0	0.2	-0.5
Fed-up feelings	0.2	0.4	1.4	0.3	0.0	0.6	1.2	0.5	0.6	0.4
High blood pressure	0.2	0.6	0.9	0.9	0.8	1.0	0.4	0.9	0.5	0.7
Supplements: Glucosamine	0.2	0.2	0.5	-0.0	0.4	0.3	0.6	-0.6	0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	-0.2	0.0	-0.3	0.4	-0.3	-1.0	-0.1
Number of incorrect matches in round	0.2	0.3	1.6	-0.3	0.3	-0.1	-1.3	-0.0	-0.0	-0.1
Alcohol usually taken with meals	0.2	0.3	1.0	-0.2	-0.7	0.1	-1.0	-0.4	-0.4	-0.8
Qualifications: None of the above	0.2	0.4	1.7	-0.2	-1.3	-0.5	0.4	0.1	-0.3	-0.9
Mouth/teeth dental problems	0.2	0.3	0.8	0.4	0.9	0.1	-0.8	0.2	0.0	0.8
Diabetes (self-reported)	0.2	0.3	0.9	0.4	0.3	0.4	0.3	0.9	0.8	0.4
Alcohol intake versus 10 years previously	0.2	0.3	1.3	0.2	0.2	0.5	-0.3	0.7	1.1	0.2
Noisy workplace	0.2	0.3	0.7	-0.3	0.8	-0.5	-0.8	-0.3	-0.6	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.4	0.6	0.8	0.7	0.2	0.9	0.4
Prospective memory result	0.2	0.2	0.7	0.1	0.8	0.3	0.8	0.2	0.1	0.4
Impedance of arm (left)	0.2	1.1	3.1	-0.7	-1.0	-1.2	-0.5	-0.8	-1.7	-0.8
Pulse wave reflection index	0.2	0.2	0.3	0.4	-0.4	0.5	-0.3	0.4	-0.6	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.6	0.0	0.4	0.8	0.6	-0.8	0.0
Forced vital capacity (FVC), Best measure	0.2	0.8	1.7	1.3	0.7	0.9	0.0	1.1	-0.4	1.2
Emphysema/chronic bronchitis	0.2	0.2	1.1	0.1	-0.2	0.2	1.0	-0.1	-0.5	0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	1.4	0.1	-0.2	-0.6	-0.7	-0.3	-1.2	0.1
Migraine (self-reported)	0.2	0.3	1.4	-0.0	0.6	0.3	1.2	-0.1	0.1	0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.5	-0.7	-0.7	-0.4	-0.6	-0.3	0.2	-0.5
Leg pain on walking	0.2	0.2	1.1	-0.4	0.5	0.2	1.1	0.1	0.1	-0.3
Mood swings	0.2	0.4	2.0	0.3	-0.2	0.7	-0.1	0.6	1.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.9	0.1	-0.0	0.5	-0.5	0.6	0.9	-0.3
Medication: Gliclazide	0.2	0.2	0.5	-0.3	-0.7	-0.3	-0.2	-0.3	0.2	-0.6
Hearing aid user	0.2	0.2	0.7	0.1	-0.0	-0.7	0.8	-0.4	-0.3	-0.0
Medication: Atorvastatin	0.2	0.3	1.0	-0.0	1.0	-0.5	-0.8	0.1	-0.0	0.2
Irritability	0.2	0.3	0.7	-0.8	-0.3	-0.7	-0.4	-0.5	-0.4	-0.6
Myopia	0.2	0.2	0.8	-0.3	-0.0	-0.5	-0.9	-0.2	0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.2	-0.0	0.7	-0.0	1.1	0.3	0.1	0.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.6	-0.1	-0.3	-0.7	-0.2	-0.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.4	-0.5	-0.1	0.6	-0.8	-0.6	-0.6
Neuroticism (2016)	0.1	0.1	0.5	-0.7	0.5	0.1	0.4	-0.2	-0.1	-0.3
Blood Eosinophil Count	0.1	1.1	2.7	1.0	1.6	0.6	0.4	0.9	1.1	1.1
Lung FEV1/FVC ratio	0.1	0.4	1.9	-0.0	1.4	0.1	-0.4	0.5	-0.4	0.2
Systolic blood pressure, automated reading	0.1	0.4	2.4	-0.1	0.5	-0.4	-1.6	-0.3	-0.0	0.1
Vitamin and mineral supplements	0.1	0.2	0.6	0.2	0.3	-0.5	-0.8	0.3	0.1	0.4
Severe depression (siblings)	0.1	0.1	0.3	0.2	-0.5	0.4	0.4	0.5	-0.0	0.0
Age when periods started (menarche)	0.1	0.3	1.4	-0.0	0.1	0.1	-1.2	-0.0	-0.6	-0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.6	0.0	0.0	0.4	0.2	0.7	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.3	-0.1	0.0	0.3	-0.6	-0.3	-0.5
Forced vital capacity (FVC)	0.1	0.5	2.3	0.3	-0.1	-0.1	-1.0	0.2	-1.5	0.0
Fluid intelligence score	0.1	0.3	0.7	-0.4	-0.2	-0.1	0.5	-0.6	-0.8	-0.5
Impedance of arm (right)	0.1	0.3	1.1	-0.2	-0.5	-0.7	-0.2	-0.4	-1.0	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	1.2	-0.2	0.1	-0.1	-1.1	0.0	-0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.5	0.3	0.2	-0.1	-0.8	0.4	-1.2	-0.0
Happiness	0.1	0.1	0.3	-0.2	0.4	0.0	-0.6	0.3	-0.2	0.0
Illnesses of mother	0.1	0.2	0.5	-0.6	-0.3	-0.1	0.1	-0.7	-0.3	-0.5
Blood clot in the leg (DVT)	0.1	0.1	0.6	-0.2	0.6	-0.2	0.8	0.3	-0.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.6	0.2	0.0	0.4	1.2	0.1	-0.1	0.1
Medication: Amlodipine	0.1	0.1	0.4	0.2	0.5	0.2	0.2	-0.1	-0.6	0.4
Birth weight	0.1	0.1	0.3	0.5	0.1	0.3	0.4	0.3	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.1	0.0	0.4	0.2	0.1	-0.3	-0.4
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.6	-0.1	-0.5	0.1	-0.4	-0.5	-0.4
Medication: Allopurinol	0.1	0.1	0.3	0.3	-0.6	-0.0	-0.3	0.3	0.2	0.0
Had major operations	0.1	0.1	0.2	-0.0	0.4	0.0	0.2	-0.2	0.1	0.4
Family relationship satisfaction	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.4	-0.1	0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.7	-0.4	0.2	-0.3	-0.8	-0.2	0.3	-0.0
Average weekly red wine intake	0.1	0.2	0.7	0.4	0.1	0.5	0.8	0.0	0.3	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.0	-0.0	-0.1	-0.1	0.5	0.5	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.5	0.5	0.0	-0.5	-0.2	-0.2	-0.2
Ever smoked	0.1	0.2	0.4	-0.3	0.3	-0.1	-0.4	-0.4	-0.6	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.5	0.1	-0.4	0.3	0.7	0.1	-0.1	-0.0
Risk taking	0.1	0.2	0.3	-0.3	-0.4	-0.3	-0.1	-0.4	0.6	-0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.7	0.7	0.4	0.5	0.8	0.7	0.6	0.6
Ever depressed for a whole week	0.1	0.2	0.4	-0.2	-0.6	-0.2	0.5	-0.4	0.6	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.4	0.3	-0.2	0.7	0.6	0.3	0.1	0.1
Depressed Affect (Nagel 2018)	0.0	0.0	0.2	0.1	0.0	-0.0	-0.4	0.0	-0.3	0.0
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	-0.4	-0.1	0.2	0.7	-0.3	-0.4	-0.3
Triglycerides	0.0	0.0	0.1	0.2	0.2	0.3	0.3	-0.0	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.2	-0.1	-0.1	-0.3	0.4	0.4	0.1
Hair Pigment	0.0	1.1	1.9	1.3	1.2	1.4	0.2	0.9	1.1	0.9
Tanning	0.0	0.5	1.6	0.8	-0.3	0.5	1.3	0.8	-0.1	0.4
Relative age of first facial hair	0.0	0.1	0.3	-0.1	0.1	-0.2	-0.5	0.1	-0.2	-0.3
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.2	-0.2	0.1	0.2	-0.0	0.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.1	0.2	0.1	0.0	0.4	-0.2	0.1	0.3	-0.1
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.0	-0.1	-0.4	-0.1	0.0	-0.5	-0.2
Pulse rate, automated reading	0.0	0.1	0.7	0.1	-0.2	0.3	0.3	0.2	0.8	-0.3
Mother’s age at death	0.0	0.1	0.2	0.4	-0.2	-0.2	0.2	-0.2	-0.2	0.2

Hub : Genes

C9orf68

Models

Trait associations