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chr19:11,858,484-14,880,197

Best TWAS P=2.96e-133 · Best GWAS P=8.22e-142 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Brain Caudate basal ganglia	FARSA	0.22	0.08	lasso	3	0.04	3.0e-02	-24.30	-24.6	3.0e-133	0.94	0.01	0.85	TRUE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST1	0.03	0.00	blup	47	0.01	2.5e-02	17.00	20.2	7.3e-91	-0.57	0.03	0.09	TRUE
9	GTEx	Brain Cerebellum	GCDH	0.48	0.48	lasso	6	0.49	1.5e-16	8.44	-15.0	5.2e-51	0.82	0.02	0.98	TRUE
56	YFS	Blood	DNASE2	0.22	0.27	enet	27	0.29	4.5e-97	17.20	-14.5	8.1e-48	0.42	1.00	0.00	TRUE
32	GTEx	Nerve Tibial	MAN2B1	0.14	0.01	enet	57	0.03	4.0e-03	-2.40	10.6	2.8e-26	-0.20	0.59	0.05	TRUE
28	GTEx	Muscle Skeletal	IER2	0.08	0.00	enet	12	0.00	4.6e-01	-5.33	-10.1	5.6e-24	0.44	0.20	0.61	TRUE
58	YFS	Blood	MAN2B1	0.13	0.07	enet	32	0.12	3.1e-38	-9.76	8.6	1.2e-17	-0.24	1.00	0.00	TRUE
19	GTEx	Colon Sigmoid	MAN2B1	0.28	0.08	enet	22	0.17	1.1e-06	-2.00	8.2	1.8e-16	-0.18	0.17	0.17	TRUE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAN2B1	0.13	0.09	enet	14	0.12	4.4e-13	-1.58	8.0	1.7e-15	-0.20	0.93	0.07	TRUE
24	GTEx	Esophagus Muscularis	MAN2B1	0.16	0.05	enet	30	0.09	4.4e-06	-3.01	7.5	8.6e-14	-0.17	0.82	0.02	TRUE
2	CommonMind	Brain Pre-frontal Cortex	LOC113230	0.08	0.12	lasso	2	0.11	1.1e-13	6.68	6.8	7.9e-12	-0.05	0.00	1.00	TRUE
78	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C19orf56	0.42	0.00	lasso	5	0.00	1.1e-01	6.55	6.6	4.9e-11	-0.20	0.00	0.03	TRUE
53	NTR	Blood	DNASE2	0.05	0.05	bslmm	321	0.05	1.7e-16	11.70	-6.2	5.6e-10	0.30	1.00	0.00	TRUE
16	GTEx	Cells Transformed fibroblasts	MAN2B1	0.15	0.10	enet	17	0.08	2.7e-06	-2.34	5.6	2.8e-08	-0.11	0.99	0.00	TRUE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAN2B1	0.03	0.01	blup	22	0.03	5.8e-04	-3.00	5.4	6.1e-08	-0.09	0.08	0.42	TRUE
45	GTEx	Thyroid	MAN2B1	0.09	0.01	lasso	6	0.01	6.0e-02	6.55	5.2	1.9e-07	-0.14	0.09	0.19	TRUE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF709	0.02	0.02	blup	56	0.01	9.8e-03	5.14	5.2	2.4e-07	-0.12	0.12	0.03	TRUE
37	GTEx	Pituitary	GCDH	0.42	0.30	lasso	5	0.29	4.2e-08	-23.70	-23.9	2.2e-126	0.96	0.01	0.98	FALSE
23	GTEx	Esophagus Muscularis	HOOK2	0.13	0.04	lasso	3	0.00	3.3e-01	-23.70	23.8	3.8e-125	-0.94	0.01	0.96	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	FARSA	0.26	0.24	lasso	5	0.18	2.3e-06	-22.50	-23.1	5.2e-118	0.91	0.01	0.99	FALSE
47	GTEx	Vagina	GCDH	0.36	0.01	lasso	5	0.00	3.3e-01	-25.40	-22.0	5.0e-107	0.82	0.02	0.62	FALSE
29	GTEx	Muscle Skeletal	FARSA	0.05	0.05	lasso	3	0.05	1.3e-05	-22.60	-21.8	2.1e-105	0.91	0.06	0.94	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DAND5	0.03	0.02	blup	31	0.03	3.0e-04	-13.60	21.2	4.4e-100	-0.83	0.00	0.96	FALSE
79	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MAST1	0.08	0.04	lasso	5	0.05	4.1e-04	17.20	20.7	1.5e-95	-0.65	0.03	0.35	FALSE
11	GTEx	Brain Cortex	GCDH	0.33	0.23	lasso	4	0.26	7.7e-08	-24.30	-20.5	5.5e-93	0.93	0.01	0.99	FALSE
25	GTEx	Lung	GCDH	0.25	0.14	enet	16	0.15	1.7e-11	-25.40	-20.2	1.1e-90	0.89	0.00	1.00	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	ZNF443	0.18	0.01	enet	15	0.04	1.4e-02	-23.60	-19.5	2.8e-84	0.59	0.02	0.76	FALSE
33	GTEx	Ovary	GCDH	0.35	0.02	enet	1	0.02	1.3e-01	-18.20	-18.2	1.1e-73	0.84	0.01	0.89	FALSE
10	GTEx	Brain Cerebellum	AD000092.3	0.40	0.15	lasso	3	0.19	2.2e-06	8.58	-18.1	5.4e-73	0.88	0.03	0.96	FALSE
44	GTEx	Testis	CTC-425F1.4	0.14	0.03	enet	9	0.05	2.0e-03	-22.60	17.9	8.3e-72	-0.73	0.04	0.79	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	CALR	0.03	0.01	blup	32	0.01	1.2e-02	-13.60	17.9	9.0e-72	-0.82	0.02	0.62	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	RTBDN	0.03	0.03	lasso	2	0.02	2.3e-03	17.20	-17.5	1.5e-68	0.42	0.03	0.86	FALSE
35	GTEx	Pancreas	GCDH	0.19	0.10	lasso	6	0.09	1.1e-04	-18.20	-17.4	4.0e-68	0.82	0.02	0.97	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	RAD23A	0.20	0.05	lasso	3	0.04	1.7e-02	-13.60	-16.9	3.2e-64	0.73	0.03	0.74	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNASE2	0.04	0.01	enet	6	0.02	1.1e-03	17.00	16.8	1.3e-63	-0.43	0.02	0.09	FALSE
36	GTEx	Pancreas	FARSA	0.18	0.01	enet	12	0.07	9.3e-04	-16.90	-16.8	4.2e-63	0.75	0.02	0.89	FALSE
51	GTEx	Whole Blood	CTD-2265O21.7	0.08	0.02	enet	9	0.04	1.5e-04	17.30	-16.6	9.0e-62	0.40	0.45	0.04	FALSE
27	GTEx	Muscle Skeletal	DNASE2	0.19	0.16	enet	15	0.16	3.5e-15	17.00	-16.5	3.9e-61	0.43	1.00	0.00	FALSE
49	GTEx	Whole Blood	GCDH	0.10	0.03	lasso	4	0.03	1.4e-03	8.58	-15.7	2.3e-55	0.82	0.05	0.87	FALSE
31	GTEx	Muscle Skeletal	CTD-2265O21.7	0.16	0.12	enet	25	0.13	1.1e-12	12.80	-15.5	3.9e-54	0.44	1.00	0.00	FALSE
50	GTEx	Whole Blood	DNASE2	0.09	0.03	enet	9	0.03	1.3e-03	17.30	-15.4	1.4e-53	0.39	0.41	0.07	FALSE
42	GTEx	Spleen	MAN2B1	0.33	-0.01	enet	25	0.06	1.6e-02	-7.78	15.3	4.8e-53	-0.35	0.03	0.26	FALSE
52	NTR	Blood	CALR	0.04	0.03	lasso	8	0.02	4.2e-08	-17.10	15.3	9.8e-53	-0.75	0.84	0.16	FALSE
7	GTEx	Brain Cerebellar Hemisphere	GCDH	0.62	0.43	lasso	5	0.49	1.7e-14	8.58	-15.2	4.8e-52	0.79	0.05	0.95	FALSE
8	GTEx	Brain Cerebellar Hemisphere	DNASE2	0.46	0.10	lasso	8	0.06	9.8e-03	-13.60	-14.7	4.0e-49	0.68	0.04	0.55	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	CALR	0.01	0.01	enet	4	0.01	8.3e-04	-23.60	14.6	3.8e-48	-0.77	0.01	0.69	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	MAST1	0.03	0.04	enet	9	0.03	3.4e-04	11.30	14.4	7.2e-47	-0.37	0.30	0.06	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	FARSA	0.05	0.04	blup	33	0.05	1.8e-06	8.44	-14.3	2.2e-46	0.76	0.19	0.77	FALSE
48	GTEx	Whole Blood	HOOK2	0.07	0.01	enet	19	0.02	8.1e-03	-2.98	13.9	8.3e-44	-0.61	0.02	0.88	FALSE
40	GTEx	Small Intestine Terminal Ileum	CTC-425F1.4	0.26	0.13	enet	22	0.08	6.1e-03	-2.11	12.9	6.1e-38	-0.35	0.04	0.42	FALSE
41	GTEx	Spleen	HOOK2	0.50	0.07	lasso	5	0.23	1.6e-06	2.08	12.6	1.9e-36	-0.51	0.02	0.67	FALSE
18	GTEx	Cells Transformed fibroblasts	FARSA	0.08	0.00	enet	28	0.00	4.4e-01	-23.30	-12.2	2.5e-34	0.54	0.04	0.54	FALSE
26	GTEx	Muscle Skeletal	GCDH	0.13	0.00	enet	11	0.00	4.6e-01	2.26	-11.5	1.3e-30	0.55	0.08	0.48	FALSE
17	GTEx	Cells Transformed fibroblasts	WDR83	0.08	0.00	lasso	3	0.02	1.1e-02	11.30	-11.1	1.4e-28	0.32	0.07	0.05	FALSE
4	GTEx	Artery Tibial	GCDH	0.08	0.10	lasso	3	0.09	1.8e-07	8.58	-10.7	9.1e-27	0.69	0.10	0.90	FALSE
43	GTEx	Spleen	SYCE2	0.38	0.05	lasso	7	0.01	1.7e-01	8.58	10.5	9.9e-26	-0.58	0.03	0.30	FALSE
30	GTEx	Muscle Skeletal	CTC-250I14.6	0.10	0.00	enet	12	0.00	1.6e-01	-5.33	-10.1	6.5e-24	0.44	0.49	0.39	FALSE
13	GTEx	Breast Mammary Tissue (Female)	MAN2B1	0.08	0.00	lasso	1	0.00	2.4e-01	-9.76	9.8	1.7e-22	-0.29	0.02	0.37	FALSE
39	GTEx	Skin Sun Exposed Lower leg	GCDH	0.16	0.21	lasso	3	0.20	1.4e-16	8.58	-9.5	2.8e-21	0.64	1.00	0.00	FALSE
38	GTEx	Pituitary	NACC1	0.46	-0.01	enet	47	0.11	1.2e-03	18.10	-8.9	6.4e-19	0.19	0.05	0.16	FALSE
22	GTEx	Esophagus Mucosa	GCDH	0.26	0.28	lasso	2	0.27	5.2e-18	8.44	-8.8	1.1e-18	0.65	1.00	0.00	FALSE
12	GTEx	Brain Frontal Cortex BA9	GCDH	0.28	0.31	lasso	1	0.25	3.0e-07	8.58	-8.6	9.2e-18	0.62	0.56	0.36	FALSE
46	GTEx	Thyroid	SYCE2	0.09	0.10	lasso	1	0.09	2.2e-07	8.58	8.6	9.2e-18	-0.62	0.86	0.12	FALSE
57	YFS	Blood	FARSA	0.02	0.03	lasso	1	0.02	1.3e-07	8.44	-8.4	3.2e-17	0.64	0.82	0.18	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	GCDH	0.41	0.17	lasso	2	0.16	3.3e-18	8.44	-8.3	1.4e-16	0.64	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MAN2B1	0.05	0.03	lasso	2	0.03	5.1e-05	-9.76	8.2	1.6e-16	-0.21	0.35	0.02	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	GCDH	0.26	0.26	lasso	11	0.25	6.1e-32	8.44	-8.2	1.9e-16	0.63	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GCDH	0.22	0.24	lasso	5	0.25	1.0e-29	8.44	-8.0	1.4e-15	0.62	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MAN2B1	0.15	0.06	lasso	2	0.03	2.5e-02	6.71	7.9	2.5e-15	-0.24	0.01	0.22	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNASE2	0.03	0.01	enet	9	0.01	5.5e-04	13.60	7.9	3.2e-15	-0.11	0.05	0.03	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAN2B1	0.06	0.03	lasso	2	0.01	4.3e-02	6.71	7.8	5.5e-15	-0.24	0.06	0.35	FALSE
34	GTEx	Ovary	AD000092.3	0.29	-0.01	lasso	6	0.00	2.9e-01	8.44	-7.5	4.7e-14	0.58	0.02	0.70	FALSE
20	GTEx	Colon Transverse	WDR83	0.18	0.00	enet	32	0.03	1.5e-02	0.39	7.1	1.2e-12	-0.39	0.03	0.13	FALSE
5	GTEx	Brain Caudate basal ganglia	hsa-mir-1199	0.31	0.21	lasso	1	0.12	1.9e-04	6.68	6.7	2.4e-11	-0.04	0.00	0.99	FALSE
81	The Cancer Genome Atlas	Soft Tissue Sarcoma	MAN2B1	0.40	0.08	blup	38	0.12	1.2e-07	-1.94	6.4	1.9e-10	-0.20	0.71	0.13	FALSE
82	The Cancer Genome Atlas	Stomach Adenocarcinoma	GCDH	0.13	0.08	lasso	3	0.07	7.7e-06	8.44	-6.3	2.2e-10	0.59	0.55	0.05	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	PALM3	0.04	0.03	enet	3	0.03	3.6e-04	5.18	-6.3	3.2e-10	0.07	0.02	0.92	FALSE
64	The Cancer Genome Atlas	Glioblastoma Multiforme	GCDH	0.19	0.13	enet	5	0.09	9.4e-04	8.44	-6.0	1.5e-09	0.57	0.02	0.32	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MAN2B1	0.02	0.01	blup	26	0.02	3.1e-03	-3.00	6.0	2.3e-09	-0.12	0.03	0.38	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	PALM3	0.09	0.04	lasso	2	0.05	1.2e-05	5.18	-5.8	5.0e-09	0.07	0.12	0.88	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF709	0.05	0.05	enet	8	0.06	3.1e-07	5.11	5.6	1.7e-08	-0.12	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	C19orf56	0.02	0.01	blup	23	0.01	1.0e-03	-2.40	5.5	3.0e-08	-0.13	0.01	0.89	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	hsa-mir-1199	0.13	0.08	enet	16	0.08	5.7e-10	6.69	5.5	3.1e-08	-0.03	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF443	0.09	0.11	enet	8	0.08	1.7e-05	5.60	5.4	5.7e-08	-0.12	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAN2B1	0.02	0.01	blup	27	0.01	1.7e-03	-2.34	5.4	8.0e-08	-0.09	0.12	0.46	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF709	0.03	0.03	enet	8	0.03	2.7e-04	5.60	5.1	2.7e-07	-0.14	0.34	0.03	FALSE